hypersplenism

Summary

Summary: Condition characterized by splenomegaly, some reduction in the number of circulating blood cells in the presence of a normal or hyperactive bone marrow, and the potential for reversal by splenectomy.

Top Publications

  1. Subhasis R, Rajiv C, Kumar S, Kumar A, Kumar P. Surgical treatment of massive splenomegaly and severe hypersplenism secondary to extrahepatic portal venous obstruction in children. Surg Today. 2007;37:19-23 pubmed
    Massive splenomegaly with severe hypersplenism can occur as a late complication of portal hypertension (PH) caused by extrahepatic portal venous obstruction (EHPVO) in children...
  2. Oliveira J, Valbuena C, Baldaia Moreira A, Fonseca E, Soares C, Leao Teles E, et al. Splenomegaly, hypersplenism and peripheral blood cytopaenias in patients with classical Anderson-Fabry disease. Virchows Arch. 2008;453:291-300 pubmed publisher
    ..Sinusoidal endothelial involvement resulting in compromise of splenic blood flow may be the cause of congestive splenomegaly and hypersplenism in classical AFD.
  3. Kawanaka H, Akahoshi T, Kinjo N, Konishi K, Yoshida D, Anegawa G, et al. Impact of antithrombin III concentrates on portal vein thrombosis after splenectomy in patients with liver cirrhosis and hypersplenism. Ann Surg. 2010;251:76-83 pubmed publisher
    ..A total of 50 consecutive cirrhotic patients who underwent laparoscopic splenectomy for hypersplenism were enrolled into this study...
  4. Ozdil B, Akkiz H, Sandikci M, Kece C, Cosar A. Recurrent hypersplenism caused by giant accessory spleen due to portal hypertension after splenectomia. Platelets. 2010;21:70-1 pubmed publisher
    ..spleen should be borne in mind in patients diagnosed with immune thrombocytopenic purpura with relapsing hypersplenism following splenectomy...
  5. Murata K, Ito K, Yoneda K, Shiraki K, Sakurai H, Ito M. Splenectomy improves liver function in patients with liver cirrhosis. Hepatogastroenterology. 2008;55:1407-11 pubmed
    Partial splenic embolization or splenectomy has been reported to improve liver function as well as hypersplenism. The aim of this study was to evaluate the effects of splenectomy in patients with liver cirrhosis (LC) on liver function...
  6. Pinto A, Namyslowski J, Pandya P. Severe thrombocytopenia due to hypersplenism successfully treated with partial splenic embolization in preoperative management. South Med J. 2005;98:481-3 pubmed
    b>Hypersplenism is a known complication of portal hypertension secondary to cirrhosis of the liver...
  7. Ushitora Y, Tashiro H, Takahashi S, Amano H, Oshita A, Kobayashi T, et al. Splenectomy in chronic hepatic disorders: portal vein thrombosis and improvement of liver function. Dig Surg. 2011;28:9-14 pubmed publisher
    Splenectomy is gaining increasing importance for cirrhotic patients with hypersplenism. However, its safety and efficacy for patients with chronic liver disease remain unclear...
  8. Wang Y, Ye H, Ye Z, Zhu Y, Xie Z, Zhu J, et al. Laparoscopic splenectomy and azygoportal disconnection for bleeding varices with hypersplenism. J Laparoendosc Adv Surg Tech A. 2008;18:37-41 pubmed publisher
    ..and upper stomach were performed in 25 patients with cirrhosis, bleeding portal hypertension, and secondary hypersplenism between January 2000 and October 2006...
  9. Petroianu A, De Oliveira A, Alberti L. Hypersplenism in schistosomatic portal hypertension. Arch Med Res. 2005;36:496-501 pubmed
    ..For many years, the hematologic changes occurring in hepatosplenic Manson's schistosomiasis have been defined as hypersplenism. Initially, the belief was that removal of the spleen would normalize the hematologic values...

More Information

Publications62

  1. Tomikawa M, Akahoshi T, Sugimachi K, Ikeda Y, Yoshida K, Tanabe Y, et al. Laparoscopic splenectomy may be a superior supportive intervention for cirrhotic patients with hypersplenism. J Gastroenterol Hepatol. 2010;25:397-402 pubmed publisher
    ..splenectomy and partial splenic embolization as supportive intervention for cirrhotic patients with hypersplenism to overcome peripheral cytopenia before the initiation of and during interferon therapy or anticancer therapy ..
  2. Ren S, Zhang S, Li M, Huang C, Liang R, Jiang A, et al. NF-?B p65 and c-Rel subunits promote phagocytosis and cytokine secretion by splenic macrophages in cirrhotic patients with hypersplenism. Int J Biochem Cell Biol. 2013;45:335-43 pubmed publisher
    ..In this study, we explored the role of NF-?B in the dysfunction of splenic macrophages in hypersplenism due to liver cirrhosis...
  3. Akahoshi T, Tomikawa M, Kawanaka H, Furusyo N, Kinjo N, Tsutsumi N, et al. Laparoscopic splenectomy with interferon therapy in 100 hepatitis-C-virus-cirrhotic patients with hypersplenism and thrombocytopenia. J Gastroenterol Hepatol. 2012;27:286-90 pubmed publisher
    ..with interferon therapy in hepatitis C virus (HCV)-cirrhotic patients with thrombocytopenia caused by hypersplenism. From December 2004 to August 2008, 100 cirrhotic patients (54 men and 46 women) underwent Lap-Sp for a ..
  4. Maksoud Filho J, Gonçalves M, Cardoso S, Gibelli N, Tannuri U. Long-term follow-up of children with extrahepatic portal vein obstruction: impact of an endoscopic sclerotherapy program on bleeding episodes, hepatic function, hypersplenism, and mortality. J Pediatr Surg. 2009;44:1877-83 pubmed publisher
    ..Nevertheless, there is a lack of published data confirming the extent of hepatic dysfunction, hypersplenism, and physical development in children with long-term follow-up...
  5. Gu J, He X, Li W, Ji J, Peng W, Li G, et al. Safety and efficacy of splenic artery coil embolization for hypersplenism in liver cirrhosis. Acta Radiol. 2012;53:862-7 pubmed publisher
    Partial splenic artery embolization is an effective treatment for hypersplenism but often lacks long-term benefits.
  6. Iriyama N, Horikoshi A, Hatta Y, Kobayashi Y, Sawada S, Takeuchi J. Localized, splenic, diffuse large B-cell lymphoma presenting with hypersplenism: risk and benefit of splenectomy. Intern Med. 2010;49:1027-30 pubmed
    ..After the operation, the patient recovered from the pancytopenia and pathology diagnosed diffuse large B-cell lymphoma. Standard CHOP plus rituximab chemotherapy was given. Complete remission has continued for 30 months. ..
  7. Yongxiang W, Zongfang L, Guowei L, Zongzheng J, Xi C, Tao W. Effects of splenomegaly and splenic macrophage activity in hypersplenism due to cirrhosis. Am J Med. 2002;113:428-31 pubmed
  8. He X, Li W, Peng W, Li G, Wang S, Xu L. Total embolization of the main splenic artery as a supplemental treatment modality for hypersplenism. World J Gastroenterol. 2011;17:2953-7 pubmed publisher
    ..and feasibility of total embolization of the main splenic artery as a supplemental treatment modality for hypersplenism with thrombocytopenia or leukocytopenia accompanying liver cirrhosis...
  9. Gonzalez Casas R, Jones E, Moreno Otero R. Spectrum of anemia associated with chronic liver disease. World J Gastroenterol. 2009;15:4653-8 pubmed
    ..The causes of anemia include acute or chronic gastrointestinal hemorrhage, and hypersplenism secondary to portal hypertension...
  10. González Rodríguez F, Puñal J, Beiras Torrado A, Potel Lesquereaux J. [Splenectomy in massive splenomegaly due to hypersplenism]. Cir Esp. 2008;83:95-6 pubmed
  11. Shinkai M, Ohhama Y, Honda S, Kitagawa N, Mochizuki K, Take H, et al. Recanalized umbilical vein as a conduit for mesenterico/porto-Rex bypass for patients with extrahepatic portal vein obstruction. Pediatr Surg Int. 2011;27:315-9 pubmed publisher
    ..Case 1 was an 11-year-old boy diagnosed with rupture of the esophageal varices and hypersplenism due to congenital extrahepatic portal hypertension...
  12. Zuchini R, Huang C, Tsai H, Huang S, Lin C, Chen C, et al. Electromagnetic thermoablation to treat thrombocytopenia in cirrhotic and hypersplenic rats. J Gastroenterol Hepatol. 2010;25:1578-86 pubmed publisher
    Thrombocytopenia due to hypersplenism is usually a serious condition in cirrhotic patients who have undergone invasive procedures...
  13. Gajin P, Radević B, Nenezic D, Ilijevski N, Ješić Vukićević R, Radak D. [Distal splenorenal shunt with partial spleen resection]. Srp Arh Celok Lek. 2007;135:293-7 pubmed
    b>Hypersplenism is a common complication of portal hypertension. Cytopenia in hypersplenism is predominantly caused by splenomegaly...
  14. Sasaki A, Nitta H, Otuska K, Kimura Y, Obuchi T, Wakabayashi G. Concomitant laparoscopic splenectomy and cholecystectomy. Surg Laparosc Endosc Percutan Tech. 2010;20:66-8 pubmed publisher
    ..for laparoscopic splenectomy included hereditary spherocytosis (4 patients), splenic artery aneurysm (2), hypersplenism (2), and Evans syndrome (1)...
  15. Hayashi H, Beppu T, Okabe K, Masuda T, Okabe H, Ishiko T, et al. Therapeutic factors considered according to the preoperative splenic volume for a prolonged increase in platelet count after partial splenic embolization for liver cirrhosis. J Gastroenterol. 2010;45:554-9 pubmed publisher
    ..In patients with splenic volumes >700 ml, the noninfarcted splenic area is significant. ..
  16. Abdul Wahab J, Naznin M, Suhaimi A, Amir Hamzah A. Favourable response to splenectomy in familial myelodysplastic syndrome. Singapore Med J. 2007;48:e206-8 pubmed
    ..Both remained clinically stable throughout the illness. Splenectomy appeared to have fully corrected the cytopenia in one of them. ..
  17. Unzurrunzaga A, Martinez E, Miguélez J, Cazallas J, Mayo J, Echevarría J. Partial splenic embolization as a treatment for hypersplenism in HIV/hepatitis C virus-co-infected patients. AIDS. 2007;21:885-7 pubmed
  18. Liu Q, Ma K, He Z, Dong J, Hua X, Huang X, et al. Radiofrequency ablation for hypersplenism in patients with liver cirrhosis: a pilot study. J Gastrointest Surg. 2005;9:648-57 pubmed
    ..We investigated the feasibility and efficacy of radiofrequency ablation for hypersplenism and its effect on liver function in patients with liver cirrhosis and portal hypertension...
  19. Zhu J, Wang Y, Ye Z, Zhao T, Zhu Y, Xie Z, et al. Laparoscopic versus open splenectomy for hypersplenism secondary to liver cirrhosis. Surg Laparosc Endosc Percutan Tech. 2009;19:258-62 pubmed publisher
    ..postsurgical complications and better postoperative recovery were observed, but it is contraindicated for hypersplenism secondary to liver cirrhosis owing to technical difficulties associated with splenomegaly, well-developed ..
  20. Li Z, Zhang S. [Changes in splenic macrophage function of hypersplenism due to portal hypertension]. Zhonghua Wai Ke Za Zhi. 2009;47:89-91 pubmed
    To investigate the changes in function of splenic macrophages of hypersplenism due to portal hypertension (PH), and to provide experimental evidence for exploring the immune function of spleen in PH...
  21. Li Z, Zhang Y, Gao J, Zhang P, Wang J, Liu X. [Expression and significance of Toll-like receptor 4 of splenic macrophage in patients with hypersplenism due to portal hypertension]. Zhonghua Yi Xue Za Zhi. 2004;84:1088-91 pubmed
    To observe the change in expression of Toll-like receptor 4 (TLR4) of splenic macrophage in patients with hypersplenism due to portal hypertension (PH), and investigate the role of TLR4 of splenic macrophage in hypersplenism...
  22. Schmults C. Leukemia cutis (chronic lymphocytic leukemia-low grade B cell). Dermatol Online J. 2002;8:14 pubmed
  23. Koconis K, Singh H, Soares G. Partial splenic embolization in the treatment of patients with portal hypertension: a review of the english language literature. J Vasc Interv Radiol. 2007;18:463-81 pubmed
    ..The literature, however, is limited in quality. Given the potential benefits of partial splenic embolization, further investigation is warranted to allow evidence-based evaluation of its use. ..
  24. Senyuz O, Yesildag E, Kuruoglu S, Yeker Y, Emir H. Caroli's disease in children: is it commonly misdiagnosed?. Acta Paediatr. 2005;94:117-20 pubmed
    ..disease: an infant with fulminant liver failure, a teenager with persistent biliary fistula, a boy with hypersplenism in the face of portal hypertension and a girl with variceal bleeding...
  25. Zach M, Thalhammer G, Eber E. Partial splenectomy in CF patients with hypersplenism. Arch Dis Child. 2003;88:649 pubmed
  26. El Kininy W, Kearney L, Hosam N, Broe P, Keeling A. Recurrent variceal haemorrhage managed with splenic vein stenting. Ir J Med Sci. 2017;186:323-327 pubmed publisher
    ..Often these would negate the need for invasive splenectomy surgery for the treatment of symptomatic hypersplenism and varices...
  27. Komo T, Hihara J, Kanou M, Kohashi T, Ohmori I, Yoshimitsu M, et al. Splenic hamartoma associated with thrombocytopenia: A case report. Int J Surg Case Rep. 2017;39:172-175 pubmed publisher
    ..Making definitive preoperative diagnosis is difficult in splenic hamartomas. Surgery is necessary for diagnosis when malignancy cannot be ruled out. Surgery may also improve symptoms of hypersplenism, including thrombocytopenia.
  28. Wang Q, Sun K, Li X, Peng B, Liang L. Surgical treatment for hepatocellular carcinoma and secondary hypersplenism. Hepatobiliary Pancreat Dis Int. 2006;5:396-400 pubmed
    ..in China, patients with HCC are often complicated by hepatitis B related liver cirrhosis and secondary hypersplenism. This study was undertaken to evaluate the effect and indications of synchronous hepatectomy and splenectomy ..
  29. Kundzina L, Lejniece S. Klippel-Trenaunay-Weber syndrome with atypical presentation of hypersplenism and nephrotic syndrome: a case report. J Med Case Rep. 2017;11:243 pubmed publisher
    Klippel-Trenaunay-Weber syndrome is a rare syndrome; unfortunately, very few studies of the connection between hypersplenism, nephrotic syndrome, and Klippel-Trenaunay-Weber syndrome have been published...
  30. Chen T, Chen C, Huang T, Tsang L, Ou H, Yu C, et al. Predictive factors for persistent splenomegaly and hypersplenism after adult living donor liver transplantation. Transplant Proc. 2012;44:752-4 pubmed publisher
    The aim of this study was to evaluate predictive factors for persistent splenomegaly and hypersplenism after living donor liver transplantation (LDLT)...
  31. Wani N, Parray F. Splenectomy in idiopathic hypersplenism. Int Surg. 2006;91:157-61 pubmed
    The therapeutic effects of splenectomy in 15 patients with idiopathic hypersplenism were studied. The mean age was 43 years (range, 5-72 years). The male to female ratio was 1:1.14...
  32. Ohmoto K, Yoshioka N, Tomiyama Y, Shibata N, Takesue M, Yoshida K, et al. Improved prognosis of cirrhosis patients with esophageal varices and thrombocytopenia treated by endoscopic variceal ligation plus partial splenic embolization. Dig Dis Sci. 2006;51:352-8 pubmed
    ..31 for death (P = 0.04). These results suggest that the combination of EVL plus PSE can prevent the recurrence of varices, progression to variceal bleeding, and death in cirrhosis patients with esophageal varices and thrombocytopenia. ..
  33. Tsutsumi N, Tomikawa M, Akahoshi T, Kawanaka H, Ota M, Sakaguchi Y, et al. Pancreatic fistula after laparoscopic splenectomy in patients with hypersplenism due to liver cirrhosis: effect of fibrin glue and polyglycolic acid felt on prophylaxis of postoperative complications. Am J Surg. 2016;212:882-888 pubmed publisher
    ..acid (PGA) felt on prevention of pancreatic fistula (PF) after laparoscopic splenectomy in patients with hypersplenism due to liver cirrhosis. Fifty consecutive patients were enrolled in this prospective study...
  34. Jiang X, Gao F, Ma Y, Feng S, Liu X, Zhou H. Percutaneous Microwave Ablation in the Spleen for Treatment of Hypersplenism in Cirrhosis Patients. Dig Dis Sci. 2016;61:287-92 pubmed publisher
    ..estimate the feasibility and therapeutic effectiveness of percutaneous microwave ablation in the treatment of hypersplenism in cirrhosis...
  35. Duan Y, Gao Y, Ni X, Wang Y, Feng L, Liang P. Changes in peripheral lymphocyte subsets in patients after partial microwave ablation of the spleen for secondary splenomegaly and hypersplenism: a preliminary study. Int J Hyperthermia. 2007;23:467-72 pubmed
    Microwave ablation therapy for secondary splenomegaly and hypersplenism has been shown to be effective from pre-clinical animal models and clinical investigations...
  36. Han D, Tang R, Wang L, Li A, Huang X, Shen S, et al. Case report of a modified Meso-Rex bypass as a treatment technique for late-onset portal vein cavernous transformation with portal hypertension after adult deceased-donor liver transplantation. Medicine (Baltimore). 2017;96:e7208 pubmed publisher
    ..An adult male patient with post-liver transplantation portal vein cavernous transformation suffered from hypersplenism and elevated hepatic enzymes...
  37. Addeo P, Nappo G, Felli E, Oncioiu C, Faitot F, Bachellier P. Management of the splenic vein during a pancreaticoduodenectomy with venous resection for malignancy. Updates Surg. 2016;68:241-246 pubmed
    ..has been associated with the development of sinistral portal hypertension, gastrointestinal bleeding and hypersplenism over the long term...
  38. Petersons A, Volrats O, Bernsteins A. The first experience with non-operative treatment of hypersplenism in children with portal hypertension. Eur J Pediatr Surg. 2002;12:299-303 pubmed
    ..The most widespread symptoms of PH are variceal bleeding and hypersplenism. The traditional management of hypersplenism has been splenectomy...
  39. Camba L, Aldrighetti L, Ciceri F, Bernardi M, Marktel S, Angeli E, et al. Locoregional intrasplenic chemotherapy for hypersplenism in myelofibrosis. Br J Haematol. 2001;114:638-40 pubmed
    A 79-year-old patient with post-polycythaemic myelofibrosis presented with severe hypersplenism. After splenic artery catheterization, cytosine arabinoside was given intrasplenically from November 1999 to March 2000 for 5 d/month at 10 ..
  40. Wang S, Tsai S, Chen G, Lan J, Yen T. In-111-labeled platelet scintigraphies in patients with chronic hepatitis C. Hepatogastroenterology. 2002;49:1066-8 pubmed
    ..465). The spleen to liver ratio of group A and B were 3.08 +/- 1.60 and 2.38 +/- 0.87, respectively (P = 0.870). Our study revealed that patients with hepatitis C infection may have thrombocytopenia independent of hypersplenism.
  41. Sarria Octavio de Toledo L, Cozcolluela Cabrejas R, Garcia Asensio S, Martínez Berganza T. [Wandering spleen associated to inflammatory pseudotumor]. Radiologia. 2006;48:173-6 pubmed
    ..due to compression (urinary retention, constipation), alterations in splenic function (thrombocytopenia or hypersplenism), or torsion of a vascular pedicle...
  42. Liu M, Hsieh C, Chang T, Lin J, Huang C. Radiotherapy for hypersplenism from congestive splenomegaly. Ann Saudi Med. 2004;24:198-200 pubmed
  43. Santra G, Das B. A cross-sectional study of the clinical profile and aetiological spectrum of pancytopenia in a tertiary care centre. Singapore Med J. 2010;51:806-12 pubmed
    ..Idiopathic aplastic anaemia (20.72 percent) was the commonest cause of pancytopenia, followed by hypersplenism due to chronic liver disease (11.71 percent)...
  44. Rajalingam R, Javed A, Sharma D, Sakhuja P, Singh S, Nag H, et al. Management of hypersplenism in non-cirrhotic portal hypertension: a surgical series. Hepatobiliary Pancreat Dis Int. 2012;11:165-71 pubmed
    b>Hypersplenism is commonly seen in patients with non-cirrhotic portal hypertension (NCPH). While a splenectomy alone can effectively relieve the hypersplenism, it does not address the underlying portal hypertension...
  45. Tecl F, Tuma J, Gal P, Kopecna L. [Pathology of the spleen in children--current possibilities of surgical treatment]. Rozhl Chir. 2002;81:54-6 pubmed
    ..The authors emphasize that splenectomy in children should be an exceptional operation. ..
  46. Colovic R, Boskovic D, Grubor N, Colovic N. [Floating spleen with chronic torsion of the pedicle causing splenomegaly and secondary hypersplenism]. Srp Arh Celok Lek. 2004;132:327-30 pubmed
    ..Venous stasis causes splenomegaly and sometimes secondary hypersplenism. The authors present 16...
  47. Rangaswamy M, Prabhu -, Nandini N, Manjunath G. Bone marrow examination in pancytopenia. J Indian Med Assoc. 2012;110:560-2, 566 pubmed
    ..Other causes were nutritional anaemia (16%), aplastic anaemia (14%), hypersplenism (10%), sepsis (9%) and leukaemia (5%)...
  48. Lv Y, Li X, Gong X, Xie X, Han X, Wang B. Effect of surgery treatment on hypersplenism caused by cirrhotic portal hypertension. Minerva Chir. 2013;68:409-13 pubmed
    Aim of the study was to summarize the types and quantities of peripheral hematocytopenia in the patients of hypersplenism caused by cirrhotic portal hypertension and investigate the effect of surgery, including splenectomy on the patient'..
  49. Kipper M, da Silva A, Oliveira C, Andretta I, Paim F, da Silva C, et al. Relationship between splenic sequestration and thrombocytopenia in Trypanosoma evansi infection in rats. Res Vet Sci. 2011;91:240-2 pubmed publisher
    ..The mean weight of spleen differed between group B (2.62g) and group D (0.55g). It was concluded that there is no relationship between thrombocytopenia and splenic sequestration in infection by T. evansi. ..
  50. Li D, Du C, Fan B, Huang P, Luo S, He Q. Impact of simultaneous splenectomy and orthotopic liver transplantation in patients with end-stage liver diseases and splenic hyperfunction. Hepatobiliary Pancreat Dis Int. 2012;11:489-93 pubmed
    ..performed simultaneously during liver transplantation in patients with end-stage liver diseases complicated by hypersplenism remains controversial...
  51. Lin D, Wu X, Ji X, Zhang Q, Lin Y, Chen W, et al. A novel canine model of portal vein stenosis plus thioacetamide administration-induced cirrhotic portal hypertension with hypersplenism. Cell Biochem Biophys. 2012;62:245-55 pubmed publisher
    ..TAA) presented mild cirrhosis and portal hypertension without significant symptoms of esophageal varices and hypersplenism. In contrast, animals from group 4 (PVS + TAA) showed well-developed micronodular and macronodular cirrhosis, ..
  52. Cai Y, Zhou J, Chen X, Wang Y, Wu Z, Peng B. Laparoscopic splenectomy is an effective and safe intervention for hypersplenism secondary to liver cirrhosis. Surg Endosc. 2011;25:3791-7 pubmed publisher
    ..performed this study to investigate the safety, feasibility, and effectiveness of laparoscopic splenectomy for hypersplenism secondary to liver cirrhosis...
  53. Jain S, Kalla M, Suleman A, Verma A. Proximal spleno-renal shunt with retro-aortic left renal vein in a patient with extra-hepatic portal vein obstruction: first case report. BMC Surg. 2017;17:65 pubmed publisher
    ..The patient was treated for portal hypertension and hypersplenism due to idiopathic extra-hepatic portal vein obstruction...