t cell leukemia

Summary

Summary: A malignant disease of the T-LYMPHOCYTES in the bone marrow, thymus, and/or blood.

Top Publications

  1. Chen S, Ishii N, Ine S, Ikeda S, Fujimura T, Ndhlovu L, et al. Regulatory T cell-like activity of Foxp3+ adult T cell leukemia cells. Int Immunol. 2006;18:269-77 pubmed
    Adult T cell leukemia (ATL) is an aggressive neoplastic disease, in which a quarter of the patients develop opportunistic infections due to cellular immunodeficiency...
  2. Nam C, Rabbitts T. The role of LMO2 in development and in T cell leukemia after chromosomal translocation or retroviral insertion. Mol Ther. 2006;13:15-25 pubmed
    ..In this review, we outline the current knowledge about LMO2 and some possible routes to develop reagents that might be possible macromolecular drugs in the future...
  3. Ojima T, Abe K, Ohyashiki J, Shirakata M, Yamamoto K. IL-2-regulated persistent human herpesvirus-6B infection facilitates growth of adult T cell leukemia cells. J Med Dent Sci. 2005;52:135-41 pubmed
    Human herpesvirus-6B (HHV-6B), a causative agent of exanthem subitum, infects human adult T cell leukemia (ATL) cell lines...
  4. Morales M, Perez Yarza G, Nieto Rementeria N, Boyano M, Jangi M, Atencia R, et al. Intracellular glutathione levels determine cell sensitivity to apoptosis induced by the antineoplasic agent N-(4-hydroxyphenyl) retinamide. Anticancer Res. 2005;25:1945-51 pubmed
  5. Kwon H, Ogle L, Benitez B, Bohuslav J, Montano M, Felsher D, et al. Lethal cutaneous disease in transgenic mice conditionally expressing type I human T cell leukemia virus Tax. J Biol Chem. 2005;280:35713-22 pubmed
    Type I human T cell leukemia virus (HTLV-I) is etiologically linked with adult T cell leukemia, an aggressive and usually fatal expansion of activated CD4+ T lymphocytes that frequently traffic to skin...
  6. Bellavia D, Mecarozzi M, Campese A, Grazioli P, Gulino A, Screpanti I. Notch and Ikaros: not only converging players in T cell leukemia. Cell Cycle. 2007;6:2730-4 pubmed
    ..Our findings may help in clarifying the regulatory mechanism of Ikaros alternative splicing and suggest a crosstalk among Notch3, pre-TCR signalling and spliced Ikaros variants in T cell leukemogenesis, mediated by HuD...
  7. Matsuda T, Tomita M, Uchihara J, Okudaira T, Ohshiro K, Tomoyose T, et al. Human T cell leukemia virus type I-infected patients with Hashimoto's thyroiditis and Graves' disease. J Clin Endocrinol Metab. 2005;90:5704-10 pubmed
    Autoimmune thyroid diseases have been reported to be associated with human T cell leukemia virus type I (HTLV-I) infection...
  8. Espinosa L, Cathelin S, D Altri T, Trimarchi T, Statnikov A, Guiu J, et al. The Notch/Hes1 pathway sustains NF-?B activation through CYLD repression in T cell leukemia. Cancer Cell. 2010;18:268-81 pubmed publisher
  9. Farre L, Bittencourt A, Silva Santos G, Almeida A, Silva A, Decanine D, et al. Fas 670 promoter polymorphism is associated to susceptibility, clinical presentation, and survival in adult T cell leukemia. J Leukoc Biol. 2008;83:220-2 pubmed
    ..Fas gene mutations, aberrant transcripts, and abundant expression of Fas have been reported in adult T cell leukemia (ATL)...

More Information

Publications80

  1. Lin Y, Nichols R, Letterio J, Aplan P. Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma. Blood. 2006;107:2540-3 pubmed
    ..quot; Taken together, these findings indicate that Notch1 mutations are very frequent events that are acquired relatively early in the process of leukemic transformation and are important for leukemic cell growth...
  2. Sharma V, Draheim K, Kelliher M. The Notch1/c-Myc pathway in T cell leukemia. Cell Cycle. 2007;6:927-30 pubmed
    ..Taken together, these studies demonstrate that Notch1 mediates T cell and epithelial cell transformation at least in part by sustaining c-Myc lev...
  3. Vilimas T, Mascarenhas J, Palomero T, Mandal M, Buonamici S, Meng F, et al. Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia. Nat Med. 2007;13:70-7 pubmed
    ..These findings identify NF-kappaB as one of the major mediators of Notch1-induced transformation and suggest that the NF-kappaB pathway is a potential target of future therapies of T-ALL...
  4. Rajasingh J, Raikwar H, Muthian G, Johnson C, Bright J. Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK-STAT pathway in T cell leukemia. Biochem Biophys Res Commun. 2006;340:359-68 pubmed
    Adult T cell leukemia is an aggressive and frequently fatal malignancy that expressess constitutively activated growth-signaling pathways in association with deregulated growth and resistance to apoptosis...
  5. Kniep B, Kniep E, Ozkucur N, Barz S, Bachmann M, Malisan F, et al. 9-O-acetyl GD3 protects tumor cells from apoptosis. Int J Cancer. 2006;119:67-73 pubmed
    ..Formation of acGD3 might thus represent a new mechanism how tumor cells can escape apoptosis...
  6. Boudreau R, Conrad D, Hoskin D. Apoptosis induced by protein phosphatase 2A (PP2A) inhibition in T leukemia cells is negatively regulated by PP2A-associated p38 mitogen-activated protein kinase. Cell Signal. 2007;19:139-51 pubmed
    ..Collectively, these findings indicate that PP2A and p38 MAPK have coordinate effects on signaling pathways that regulate the survival of T leukemia cells...
  7. Tsuji Y, Nakagawa T, Hatanaka M, Takeuchi T, Matsumoto E, Takenaka H, et al. Quantification of caveolin isoforms using quantitative real-time RT-PCR, and analysis of promoter CpG methylation of caveolin-1alpha in human T cell leukemia cell lines. Int J Mol Med. 2006;18:489-95 pubmed
    ..For precise analyses of the caveolin expression in human T cell leukemia cell lines, we measured the mRNA levels of caveolin isoforms, caveolin-1alpha, -1beta, -2, and -3 with real-..
  8. Hoyer K, Herling M, Bagrintseva K, Dawson D, French S, Renard M, et al. T cell leukemia-1 modulates TCR signal strength and IFN-gamma levels through phosphatidylinositol 3-kinase and protein kinase C pathway activation. J Immunol. 2005;175:864-73 pubmed
    A signaling role for T cell leukemia-1 (TCL1) during T cell development or in premalignant T cell expansions and mature T cell tumors is unknown...
  9. McCormack M, Forster A, Drynan L, Pannell R, Rabbitts T. The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development. Mol Cell Biol. 2003;23:9003-13 pubmed
    ..We conclude that there is no mandatory role for LMO2 in lymphoid development, implying that its specific role in T-cell tumorigenesis results from a reprogramming of gene expression after enforced expression in T-cell precursors...
  10. Sharma V, Calvo J, Draheim K, Cunningham L, Hermance N, Beverly L, et al. Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc. Mol Cell Biol. 2006;26:8022-31 pubmed
    ..These studies define the Notch1 molecular signature in mouse T-ALL and importantly provide mechanistic insight as to how Notch1 contributes to human T-ALL...
  11. Furre I, Møller M, Shahzidi S, Nesland J, Peng Q. Involvement of both caspase-dependent and -independent pathways in apoptotic induction by hexaminolevulinate-mediated photodynamic therapy in human lymphoma cells. Apoptosis. 2006;11:2031-42 pubmed
    ..This finding may have an impact on improved PDT effectiveness...
  12. Radtke F, Wilson A, Mancini S, MacDonald H. Notch regulation of lymphocyte development and function. Nat Immunol. 2004;5:247-53 pubmed
  13. Palomero T, Sulis M, Cortina M, Real P, Barnes K, Ciofani M, et al. Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nat Med. 2007;13:1203-10 pubmed
  14. Arimura K, Arima N, Kukita T, Inoue H, Arai A, Matsushita K, et al. Fatal splenic rupture caused by infiltration of adult T cell leukemia cells. Acta Haematol. 2005;113:255-7 pubmed
    ..The present report describes a fatal case of splenic rupture caused by infiltration of adult T cell leukemia cells and reports the mechanism of splenic rupture...
  15. Thompson B, Buonamici S, Sulis M, Palomero T, Vilimas T, Basso G, et al. The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia. J Exp Med. 2007;204:1825-35 pubmed
    ..Our data suggest that FBW7 is a novel tumor suppressor in T cell leukemia, and implicate the loss of FBW7 function as a potential mechanism of drug resistance in T-ALL.
  16. Bellavia D, Campese A, Checquolo S, Balestri A, Biondi A, Cazzaniga G, et al. Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis. Proc Natl Acad Sci U S A. 2002;99:3788-93 pubmed
    ..Together, these results suggest that the combined expression of Notch3 and pTalpha sustains T cell leukemogenesis and may represent pathognomonic molecular features of human T-ALL...
  17. Matutes E, Wotherspoon A, Parker N, Osuji N, Isaacson P, Catovsky D. Transformation of T-cell large granular lymphocyte leukaemia into a high-grade large T-cell lymphoma. Br J Haematol. 2001;115:801-6 pubmed
    ..This is the first case documented by molecular methods of the transformation of the pre-existing clone...
  18. Bellavia D, Campese A, Alesse E, Vacca A, Felli M, Balestri A, et al. Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice. EMBO J. 2000;19:3337-48 pubmed
  19. Hatanaka M, Maeda T, Ikemoto T, Mori H, Seya T, Shimizu A. Expression of caveolin-1 in human T cell leukemia cell lines. Biochem Biophys Res Commun. 1998;253:382-7 pubmed
    ..We identified caveolin-1 in one T cell leukemia cell line, a subline of Jurkat cells, by immunostaining and Western blotting...
  20. Astier Gin T, Portail J, Londos Gagliardi D, Moynet D, Blanchard S, Dalibart R, et al. Neutralizing activity and antibody reactivity toward immunogenic regions of the human T cell leukemia virus type I surface glycoprotein in sera of infected patients with different clinical states. J Infect Dis. 1997;175:716-9 pubmed
    The induction of specific neutralizing antibodies is an important part of vaccine strategy against human T cell leukemia virus type I (HTLV-I)...
  21. Akari H, Ono F, Sakakibara I, Takahashi H, Murayama Y, Hiyaoka A, et al. Simian T cell leukemia virus type I-induced malignant adult T cell leukemia-like disease in a naturally infected African green monkey: implication of CD8+ T cell leukemia. AIDS Res Hum Retroviruses. 1998;14:367-71 pubmed
    Spontaneous T cell leukemia was found in an African green monkey (Cercopithecus aethiops, AGM) naturally infected with simian T cell leukemia virus type I (STLV-I)...
  22. Yamada Y, Warren A, Dobson C, Forster A, Pannell R, Rabbitts T. The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis. Proc Natl Acad Sci U S A. 1998;95:3890-5 pubmed
    ..Thus, Lmo2 is necessary for early stages of hematopoiesis, and the Lmo2 master gene encodes a protein that has a central and crucial role in the hematopoietic development...
  23. Uchida N, Otsuka T, Arima F, Shigematsu H, Fukuyama T, Maeda M, et al. Correlation of telomerase activity with development and progression of adult T-cell leukemia. Leuk Res. 1999;23:311-6 pubmed
    ..Accordingly, ATL could be a good candidate disease for trials of telomerase inhibitors, as novel anticancer drugs...
  24. Kasai T, Iwanaga Y, Iha H, Jeang K. Prevalent loss of mitotic spindle checkpoint in adult T-cell leukemia confers resistance to microtubule inhibitors. J Biol Chem. 2002;277:5187-93 pubmed
    ..This altered localization of hsMAD1 and hsMAD2 correlated with loss of mitotic checkpoint function and chemoresistance to microtubule inhibitors...
  25. Bigouret V, Hoffmann T, Arlettaz L, Villard J, Colonna M, Ticheli A, et al. Monoclonal T-cell expansions in asymptomatic individuals and in patients with large granular leukemia consist of cytotoxic effector T cells expressing the activating CD94:NKG2C/E and NKD2D killer cell receptors. Blood. 2003;101:3198-204 pubmed
  26. Shvidel L, Duksin C, Tzimanis A, Shtalrid M, Klepfish A, Sigler E, et al. Cytokine release by activated T-cells in large granular lymphocytic leukemia associated with autoimmune disorders. Hematol J. 2002;3:32-7 pubmed
    ..The pathogenesis of associated T-LGLL and autoimmune abnormalities is not clear. In this study we have investigated the role of cytokines in the development of immune complications in LGLL...
  27. Jeffries S, Robbins D, Capobianco A. Characterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line. Mol Cell Biol. 2002;22:3927-41 pubmed
    ..3) translocation and constitutively express N(ic). Taken together, our data indicate that complex formation is likely required for neoplastic transformation by Notch(ic)...
  28. Virgilio L, Lazzeri C, Bichi R, Nibu K, Narducci M, Russo G, et al. Deregulated expression of TCL1 causes T cell leukemia in mice. Proc Natl Acad Sci U S A. 1998;95:3885-9 pubmed
    The TCL1 oncogene on human chromosome 14q32.1 is involved in the development of T cell leukemia in humans...
  29. Mori N, Fujii M, Cheng G, Ikeda S, Yamasaki Y, Yamada Y, et al. Human T-cell leukemia virus type I tax protein induces the expression of anti-apoptotic gene Bcl-xL in human T-cells through nuclear factor-kappaB and c-AMP responsive element binding protein pathways. Virus Genes. 2001;22:279-87 pubmed
  30. Yokose N, Ogata K, Sugisaki Y, Mori S, Yamada T, An E, et al. CD20-positive T cell leukemia/lymphoma: case report and review of the literature. Ann Hematol. 2001;80:372-5 pubmed
    ..Hepatomegaly and/or splenomegaly were common features. Further cases must be evaluated to understand the clinical significance of the CD20 expression on the surface of T cell malignancies...
  31. Avramis I, Kwock R, Avramis V. Taxotere and vincristine inhibit the secretion of the angiogenesis inducing vascular endothelial growth factor (VEGF) by wild-type and drug-resistant human leukemia T-cell lines. Anticancer Res. 2001;21:2281-6 pubmed
    ..Moreover, the leukemic cell lines examined here may constitute a useful model to study antiangiogenic drugs, alone or in combination with established drug regimens used against refractory leukemias...
  32. Jeon H, Lee M, Jeong Y, Lee D, Oh Y, Kim C. Adult T cell leukemia/lymphoma with lymphopenia in a Korean. J Korean Med Sci. 2000;15:233-9 pubmed
    We experienced a case of adult T cell leukemia/lymphoma (ATLL) in a 48-year-old Korean female, who has never been abroad since birth and no history of blood transfusion. The patient had hypercalcemia and multiple lymphadenopathy...
  33. Wong K, Chan J, Liu H, Man C, Kwong Y. Chromosomal abnormalities in T-cell large granular lymphocyte leukaemia: report of two cases and review of the literature. Br J Haematol. 2002;116:598-600 pubmed
    ..This is the first report describing the possible involvement of T-cell receptor genes in karyotypic aberrations in T-LGL...
  34. Mauz Körholz C, Dietzsch S, Schippel P, Banning U, Korholz D. Molecular mechanisms of hyperthermia- and cisplatin-induced cytotoxicity in T cell leukemia. Anticancer Res. 2003;23:2643-7 pubmed
    ..Therefore an intensification of chemotherapy is required...
  35. Suzuki T, Uchida Toita M, Andoh T, Yoshida M. HTLV-1 tax oncoprotein binds to DNA topoisomerase I and inhibits its catalytic activity. Virology. 2000;270:291-8 pubmed
    ..These results suggest that Tax has a novel potential to affect various cellular processes such as transcription and maintenance of genomic stability, in which DNA topoisomerase I is involved...
  36. Popal W, Boucas J, Peer Zada A, Herling M. Pharmacologic interception in T-cell leukemia 1A associated pathways as a treatment rationale for chronic lymphocytic leukemia. Leuk Lymphoma. 2010;51:1375-8 pubmed publisher
    ..Respective preliminary data indicate that differential response categories of CLL exist. Future studies will test TCL1A's inherent predictive information. ..
  37. Li T, Wang W, Chen H, Li T, Ye L. Evaluation of anti-leukemia effect of resveratrol by modulating STAT3 signaling. Int Immunopharmacol. 2010;10:18-25 pubmed publisher
    ..Taken altogether, this investigation focuses on signaling pathways involved in STAT3 by resveratrol and to delineate its molecular mechanisms underlying anti-leukemia effect. ..
  38. Yasuma K, Matsuzaki T, Yamano Y, Takashima H, Matsuoka M, Saito M. HTLV-1 subgroups associated with the risk of HAM/TSP are related to viral and host gene expression in peripheral blood mononuclear cells, independent of the transactivation functions of the viral factors. J Neurovirol. 2016;22:416-30 pubmed publisher
    Among human T cell leukemia virus type 1 (HTLV-1)-infected individuals, the risk of developing HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) across lifetime differs between ethnic groups...
  39. Berg S, Blaney S, Devidas M, Lampkin T, Murgo A, Bernstein M, et al. Phase II study of nelarabine (compound 506U78) in children and young adults with refractory T-cell malignancies: a report from the Children's Oncology Group. J Clin Oncol. 2005;23:3376-82 pubmed
    ..Further studies are planned to determine whether the addition of nelarabine to front-line therapy for T-cell leukemia in children will improve survival. ..
  40. Richardson A, de Antueno R, Duncan R, Hoskin D. Intracellular delivery of bovine lactoferricin's antimicrobial core (RRWQWR) kills T-leukemia cells. Biochem Biophys Res Commun. 2009;388:736-41 pubmed publisher
    ..We suggest that LfcinB6, in combination with a fusogenic liposome delivery system that selectively targets malignant cells, has potential as a novel anticancer agent. ..
  41. Wang J, Song D, Liu Y, Lu G, Yang S, Liu L, et al. HLA-DMB restricts human T-cell leukemia virus type-1 (HTLV-1) protein expression via regulation of ATG7 acetylation. Sci Rep. 2017;7:14416 pubmed publisher
    ..Taken together, these results suggested DMB modulated HTLV-1 protein expression through regulation of autophagosome accumulation and our findings suggested a new mechanism by which the host cells defended against HTLV-1 infection. ..
  42. Lança T, Correia D, Moita C, Raquel H, Neves Costa A, Ferreira C, et al. The MHC class Ib protein ULBP1 is a nonredundant determinant of leukemia/lymphoma susceptibility to gammadelta T-cell cytotoxicity. Blood. 2010;115:2407-11 pubmed publisher
    ..We suggest this will impact on the responsiveness to gammadelta T cell-based immunotherapy, and therefore propose ULBP1 to be used as a leukemia/lymphoma biomarker in upcoming clinical trials. ..
  43. Labrecque J, Wong R, Fricker S. A time-resolved fluorescent lanthanide (Eu)-GTP binding assay for chemokine receptors as targets in drug discovery. Methods Mol Biol. 2009;552:153-69 pubmed publisher
    ..In this chapter, using the chemokine receptor CXCR4 as an example, we describe the steps for assay optimization. In addition we describe adaptation of this assay for the high-throughput screening of chemokine antagonists. ..
  44. Lin D, Fang Z, Li X, Liu J, Lu Y. [Antigen-loaded dendritic cells trigger killing effects of specific cytotoxic T lymphocytes on Jurkat cells in vitro]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006;14:795-9 pubmed
    ..01). It is concluded that the tumor antigen-pulsed DC can induce efficient and specific anti-tumor immunity, may play a great role in clinical therapy for leukemia. ..
  45. Werner A, Tait S, de Vries E, Eldering E, Borst J. Requirement for aspartate-cleaved bid in apoptosis signaling by DNA-damaging anti-cancer regimens. J Biol Chem. 2004;279:28771-80 pubmed
    ..We conclude that Bid, cleaved by an undefined aspartate-specific protease, can be a key mediator of the apoptotic response to DNA-damaging anticancer regimens. ..
  46. Jin L, Li Y, Chen C, Sherman M, Le K, Shively J. Direct interaction of tumor suppressor CEACAM1 with beta catenin: identification of key residues in the long cytoplasmic domain. Exp Biol Med (Maywood). 2008;233:849-59 pubmed publisher
  47. Hamada M, Urabe K, Moroi Y, Koga T, Takeishi M, Fujita M, et al. A case of multifocal lupus vulgaris that preceded pulmonary tuberculosis in an immune compromised patient. J Dermatol. 2004;31:124-8 pubmed
  48. Chaves D, Sales C, de Cássia Gonçalves P, da Silva Malta M, Romanelli L, Ribas J, et al. Plasmatic proinflammatory chemokines levels are tricky markers to monitoring HTLV-1 carriers. J Med Virol. 2016;88:1438-47 pubmed publisher
    ..J. Med. Virol. 88:1438-1447, 2016. © 2016 Wiley Periodicals, Inc. ..
  49. Möhrle B, Köhler K, Jaehrling J, Brock R, Gauglitz G. Label-free characterization of cell adhesion using reflectometric interference spectroscopy (RIfS). Anal Bioanal Chem. 2006;384:407-13 pubmed
    ..Jurkat T cell leukemia cells rapidly attached to a transducer functionalized with a monoclonal antibody directed against the T cell ..
  50. Ureshino H, Shindo T, Nishikawa H, Watanabe N, Watanabe E, Satoh N, et al. Effector Regulatory T Cells Reflect the Equilibrium between Antitumor Immunity and Autoimmunity in Adult T-cell Leukemia. Cancer Immunol Res. 2016;4:644-9 pubmed publisher
    ..Close monitoring of eTreg numbers is crucial if we are to provide immunomodulatory treatments that target malignancy without severe adverse events. Cancer Immunol Res; 4(8); 644-9. ©2016 AACR. ..
  51. Fimognari C, Lenzi M, Sciuscio D, Cantelli Forti G, Hrelia P. Cell-cycle specificity of sulforaphane-mediated apoptosis in Jurkat T-leukemia cells. In Vivo. 2007;21:377-80 pubmed
    ..These findings suggest that cell vulnerability to SFN-mediated apoptosis is subject to regulation by cell-cycle-dependent mechanisms. ..
  52. Ishitsuka K. Molecular pathogenesis and its therapeutic implication for ATL. Rinsho Ketsueki. 2017;58:2004-2011 pubmed publisher
    ..Establishment of novel treatment strategies beyond cytotoxic agents for ATL are eagerly anticipated, especially for elderly patients...
  53. Ganor Y, Grinberg I, Reis A, Cooper I, Goldstein R, Levite M. Human T-leukemia and T-lymphoma express glutamate receptor AMPA GluR3, and the neurotransmitter glutamate elevates the cancer-related matrix-metalloproteinases inducer CD147/EMMPRIN, MMP-9 secretion and engraftment of T-leukemia in vivo. Leuk Lymphoma. 2009;50:985-97 pubmed publisher
    ..If so, glutamate receptors in T-cell malignancies should be blocked. ..
  54. Thorat K, Gujral S, Kumar A, Nair C. Small cell variant of T-cell prolymphocytic leukemia exhibiting suppressor phenotype. Leuk Lymphoma. 2006;47:1711-3 pubmed
  55. Koziel R, Szczepanowska J, Magalska A, Piwocka K, Duszynski J, Zablocki K. Ciprofloxacin inhibits proliferation and promotes generation of aneuploidy in Jurkat cells. J Physiol Pharmacol. 2010;61:233-9 pubmed
    ..Chromosomal instability of such cells may, at least potentially, increase a risk of cancer development...
  56. Reis Sobreiro M, Gajate C, Mollinedo F. Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions. Oncogene. 2009;28:3221-34 pubmed publisher
    ..These results also highlight the role of recruitment of Fas/CD95 signaling in lipid rafts in antimyeloma and antileukemia chemotherapy...
  57. Roy J, Van Themsche C, Demers M, Opdenakker G, Arnold B, St Pierre Y. Triggering of T-cell leukemia and dissemination of T-cell lymphoma in MMP-9-deficient mice. Leukemia. 2007;21:2506-11 pubmed
    ..These results show for the first time than lymphoma growth can occur in total absence of MMP-9 and have consequences for therapy of invasive cancers with inhibitors of MMPs...
  58. Peters L, McCarthy A, Faught C. Secondary Strongyloides stercoralis prophylaxis in patients with human T-cell lymphotropic virus type 1 infection: report of two cases. Int J Infect Dis. 2009;13:e501-3 pubmed publisher
    ..As treatment failure for complicated strongyloidiasis has been documented in severely immunosuppressed patients, secondary prophylaxis may be indicated...
  59. Morice W, Jevremovic D, Hanson C. The expression of the novel cytotoxic protein granzyme M by large granular lymphocytic leukaemias of both T-cell and NK-cell lineage: an unexpected finding with implications regarding the pathobiology of these disorders. Br J Haematol. 2007;137:237-9 pubmed
    ..These unexpected results suggest commonality between T- and NK-LGL, providing further support to the notion that T-LGL is a disorder of dysregulated, chronically stimulated, adaptive cytotoxic T-cells...
  60. Ross A, McLean T, Farber R, Weaver R, Chauvenet A, Givner L, et al. Retinitis following varicella in a vaccinated child with acute lymphoblastic leukemia. Pediatr Blood Cancer. 2005;45:191-4 pubmed
    ..Prolonged therapy with acyclovir resulted in near complete recovery. Early diagnosis of VZV retinopathy and aggressive antiviral treatment is critical to prevent acute and long-term ocular sequelae...
  61. Zimmerman E, Huang M, Leisewitz A, Wang Y, Yang J, Graves L. Identification of a novel point mutation in ENT1 that confers resistance to Ara-C in human T cell leukemia CCRF-CEM cells. FEBS Lett. 2009;583:425-9 pubmed publisher
    ..These results define G24 as critical amino acid for ENT1 nucleoside uptake and suggest that mutations in TM1 may provide a mechanism for Ara-C resistance in CCRF-CEM Ara-C/8C cells...
  62. Shanmugam H, Eow G, Nadarajan V. A case report of adult T-cell leukaemia/lymphoma. Malays J Pathol. 2009;31:63-6 pubmed
    ..Here, we discuss the pathogenesis and characteristics of ATLL as well as the detection of HTLV-1 by real time PCR...
  63. Nakata Y, Kondoh K, Fukushima S, Hashiguchi A, Du W, Hayashi M, et al. Mutated D4-guanine diphosphate-dissociation inhibitor is found in human leukemic cells and promotes leukemic cell invasion. Exp Hematol. 2008;36:37-50 pubmed
  64. Gutierrez A, Look A. NOTCH and PI3K-AKT pathways intertwined. Cancer Cell. 2007;12:411-3 pubmed
    ..This novel observation suggests the need to simultaneously inhibit both pathways as a means to improve therapeutic efficacy in human T-ALL...
  65. Hamamura R, Ohyashiki J, Kurashina R, Kobayashi C, Zhang Y, Takaku T, et al. Induction of heme oxygenase-1 by cobalt protoporphyrin enhances the antitumour effect of bortezomib in adult T-cell leukaemia cells. Br J Cancer. 2007;97:1099-105 pubmed
    ..This indicates that HMOX-1 may modulate anticancer effects of bortezomib in ATL cells, and could be a molecular target in treating ATL patients...
  66. Hu Q, Popa I, Fu K, Chen M, Chan W. Clonal CD8+ lymphocytic proliferation associated with Epstein-Barr virus infection mimicking T-cell leukemia. Leuk Lymphoma. 2007;48:1651-3 pubmed
  67. Nearman Z, Wlodarski M, Jankowska A, Howe E, Narvaez Y, Ball E, et al. Immunogenetic factors determining the evolution of T-cell large granular lymphocyte leukaemia and associated cytopenias. Br J Haematol. 2007;136:237-48 pubmed
    ..03 and 0.01 respectively); the biological relevance of this finding is questionable. The significance of additional genetic polymorphisms and their clinical correlation to evolution of T-LGL requires future analysis...
  68. Ahmad E, Kingma D, Jaffe E, Schrager J, Janik J, Wilson W, et al. Flow cytometric immunophenotypic profiles of mature gamma delta T-cell malignancies involving peripheral blood and bone marrow. Cytometry B Clin Cytom. 2005;67:6-12 pubmed
    ..In this study we compared clinical findings with flow cytometric immunophenotypic results in a series of patients with aggressive and indolent gamma delta T-cell malignancies with peripheral blood and/or bone marrow involvement...
  69. Zempleni J, Gralla M, Camporeale G, Hassan Y. Sodium-dependent multivitamin transporter gene is regulated at the chromatin level by histone biotinylation in human Jurkat lymphoblastoma cells. J Nutr. 2009;139:163-6 pubmed publisher
  70. Wiwanitkit V. A summary on the immunophenotyping of acute lymphoblastic leukemia in Thailand. Hematology. 2005;10:35-7 pubmed
    ..2%), common (26.6%) and T (19.4%) phenotypes. After performing subtype analysis, the most common phenotypes among both adult and pediatric group is still Pre-B phenotype...
  71. Lin Y, Deveney R, Barbara M, Iscove N, Nimer S, Slape C, et al. OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1. Cancer Res. 2005;65:7151-8 pubmed
    ..In addition, growth of leukemic cell lines established from OLIG2/LMO1 transgenic mice was suppressed by a gamma-secretase inhibitor, suggesting that Notch1 up-regulation is important for the proliferation of OLIG2-LMO1 leukemic cells...