respiratory tract granuloma

Summary

Summary: Granulomatous disorders affecting one or more sites in the respiratory tract.

Top Publications

  1. Tami T. Granulomatous diseases and chronic rhinosinusitis. Otolaryngol Clin North Am. 2005;38:1267-78, x pubmed
    ..This article reviews the typical presentations for some of these unusual conditions and discusses the appropriate evaluations that will lead to clinical identification and effective medical management...
  2. El Zammar O, Katzenstein A. Pathological diagnosis of granulomatous lung disease: a review. Histopathology. 2007;50:289-310 pubmed
    ..It concentrates on the most important and common entities that may be encountered and emphasizes helpful features in the differential diagnosis...
  3. Rosen Y. Pathology of sarcoidosis. Semin Respir Crit Care Med. 2007;28:36-52 pubmed
    ..A positive Kveim-Siltzbach test provides strong support for the diagnosis of sarcoidosis...
  4. Makarova O, Zubakhin A. Reactivity of alveolar macrophages during granulomatous inflammation of the lungs under conditions of acute massive blood loss. Bull Exp Biol Med. 2004;138:226-9 pubmed
    ..Suppressed production of toxic oxygen radicals in alveolar macrophages was accompanied by accelerated recovery of cells on the surface of the respiratory tract...
  5. Trisolini R, Paioli D, Patelli M, Cancellieri A, Squintani L. Bronchoalveolar lavage: intact granulomas in Mycobacterium avium pulmonary infection. Acta Cytol. 2008;52:263-4 pubmed
  6. Boring L, Gosling J, Chensue S, Kunkel S, Farese R, Broxmeyer H, et al. Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J Clin Invest. 1997;100:2552-61 pubmed
    ..These data suggest an important and unexpected role for CCR2 activation in modulating the immune response, as well as in recruiting monocytes/macrophages to sites of inflammation...
  7. León D, Retana V, Hernandez Pando R, Arellano J, Ortiz L, Valle F, et al. Pigeon hypersensitivity pneumonitis: immunohistochemical demonstration of the causative antigen in the lung. Prim Care Respir J. 2007;16:252-6 pubmed
    ..We propose that the study of pigeon antigen by immunohistochemistry may be used as part of the diagnostic approach for hypersensitivity pneumonitis...
  8. Jacobs M, Brown N, Allie N, Chetty K, Ryffel B. Tumor necrosis factor receptor 2 plays a minor role for mycobacterial immunity. Pathobiology. 2000;68:68-75 pubmed
    ..Therefore, anti-mycobacterial immunity is largely dependent on TNF signalling via the TNF-R1, while activation of TNF-R2 plays a minor role...
  9. Lu B, Rutledge B, Gu L, Fiorillo J, Lukacs N, Kunkel S, et al. Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J Exp Med. 1998;187:601-8 pubmed
    ..Our data indicate that MCP-1 is uniquely essential for monocyte recruitment in several inflammatory models in vivo and influences expression of cytokines related to T helper responses...

More Information

Publications62

  1. Rybicki B, Iannuzzi M. Epidemiology of sarcoidosis: recent advances and future prospects. Semin Respir Crit Care Med. 2007;28:22-35 pubmed
    ..In summary, the epidemiology of sarcoidosis has a promising future that should eventually provide the answers to the etiologic origins of this complex disease...
  2. Na K, Song S, Kim J, Kim Y. Subpleural pulmonary hyalinizing granuloma presenting as a solitary pulmonary nodule. J Thorac Oncol. 2007;2:777-9 pubmed
    ..In previously reported cases, most patients had ill-defined margins and usually bilateral, multiple lesions radiographically. In our case, the subpleural location is an uncommon location of this rare entity...
  3. Desai A, Miller M, Huang X, Warren J. Nitric oxide modulates MCP-1 expression in endothelial cells: implications for the pathogenesis of pulmonary granulomatous vasculitis. Inflammation. 2003;27:213-23 pubmed
    ..Cumulatively, these data suggest that NO suppresses MCP-1 expression by blunting the redox changes associated with cytokine-induced EC activation...
  4. Armbruster C, Bernhardt K, Setinek U. Pulmonary tumorlet: a case report of a diagnostic pitfall in cytology. Acta Cytol. 2008;52:223-7 pubmed
    ..Fine needle aspiration (FNA) of this cell proliferation has rarely been reported. We describe a pulmonary tumorlet associated with bronchocentric granulomatosis presenting as a tumorous consolidation on chest radiograph...
  5. Fenhalls G, Stevens L, Moses L, Bezuidenhout J, Betts J, Helden Pv P, et al. In situ detection of Mycobacterium tuberculosis transcripts in human lung granulomas reveals differential gene expression in necrotic lesions. Infect Immun. 2002;70:6330-8 pubmed
    ..These observations confirm that genes identified in models of persistence or in response to drug treatment in vitro are expressed in the human host...
  6. Fallon P, Jolin H, Smith P, Emson C, Townsend M, Fallon R, et al. IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13. Immunity. 2002;17:7-17 pubmed
    ..These mice reveal distinct spatial, temporal, and hierarchical cytokine requirements in immune function...
  7. Hashimoto S, Fujii W, Takahashi T, Shiroshita K, Sakurai T, Ueda T, et al. Pulmonary hyalinizing granuloma with hydronephrosis. Intern Med. 2002;41:463-6 pubmed
    ..The findings of abdominal CT and urography were compatible with retroperitoneal fibrosis. Steroid treatment completely reversed the initial abnormality in laboratory data and the symptoms disappeared...
  8. Tazi A, Moreau J, Bergeron A, Dominique S, Hance A, Soler P. Evidence that Langerhans cells in adult pulmonary Langerhans cell histiocytosis are mature dendritic cells: importance of the cytokine microenvironment. J Immunol. 1999;163:3511-5 pubmed
  9. Trow T, Morris D, Miller C, Homer R. Granulomatous bronchiolitis of Crohn's disease successfully treated with inhaled budesonide. Thorax. 2009;64:546-7 pubmed publisher
    ..This less toxic approach to therapy is warranted in granulomatous bronchiolitis of Crohn's disease to avoid unwanted side effects of steroids and infliximab...
  10. Shang X, Chiu B, Stolberg V, Lukacs N, Kunkel S, Murphy H, et al. Eosinophil recruitment in type-2 hypersensitivity pulmonary granulomas: source and contribution of monocyte chemotactic protein-3 (CCL7). Am J Pathol. 2002;161:257-66 pubmed
    ..Together, these results suggest that MCP-3 contributes to a significant component of eosinophil recruitment in the type-2 interstitial granuloma formation and Th2 cytokines promote its production...
  11. Shibuya K, Coulson W, Naoe S. Histopathology of deep-seated fungal infections and detailed examination of granulomatous response against cryptococci in patients with acquired immunodeficiency syndrome. Nihon Ishinkin Gakkai Zasshi. 2002;43:143-51 pubmed
    ..The third pattern demonstrated in the patient treated with HAART was characterized by the presence of CD4+ cells, greater response of histiocytes and multinucleated giant cell formation, and lack of massive capillary involvement...
  12. Fontenot A, Maier L, Canavera S, Hendry Hofer T, Boguniewicz M, Barker E, et al. Beryllium skin patch testing to analyze T cell stimulation and granulomatous inflammation in the lung. J Immunol. 2002;168:3627-34 pubmed
    ..These studies using skin patch testing provide new insight into the dynamics of T cell influx and mobilization during granulomatous inflammation...
  13. Guerrero A, Laflamme M, Agoff S, Williams W, Karmy Jones R. Primary lymphoepithelioma-like carcinoma of the lung. Can Respir J. 2001;8:431-3 pubmed
    ..The patient was treated with surgical resection. After it was determined that the neoplasm was of primary lung origin, adjunctive chemotherapy was initiated. The role of adjunctive chemotherapy in this setting is discussed...
  14. Ehlers S, Holscher C, Scheu S, Tertilt C, Hehlgans T, Suwinski J, et al. The lymphotoxin beta receptor is critically involved in controlling infections with the intracellular pathogens Mycobacterium tuberculosis and Listeria monocytogenes. J Immunol. 2003;170:5210-8 pubmed
    ..tuberculosis infection as wild-type mice, these data demonstrate that signaling of LT alpha(1)beta(2) heterotrimers via the LT beta R is an essential prerequisite for containment of intracellular pathogens...
  15. O Reilly K, Boscia J, Kaplan K, Sime P. A case of steroid responsive pulmonary hyalinising granuloma: complicated by deep venous thrombosis. Eur Respir J. 2004;23:954-6 pubmed
    ..This case study suggests that in selected patients with pulmonary hyalinising granuloma experiencing disabling symptoms and worsening pulmonary function, a trial of corticosteroids may be warranted...
  16. Bonay M, Chambellan A, Grandsaigne M, Aubier M, Soler P. Effects of diesel particles on the control of intracellular mycobacterial growth by human macrophages in vitro. FEMS Immunol Med Microbiol. 2006;46:419-25 pubmed
    ..Whether exposure to DEPs influences the adaptive immune response against mycobacterial infections remains to be determined...
  17. de Noronha A, Bafica A, Nogueira L, Barral A, Barral Netto M. Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production. Pathol Res Pract. 2008;204:155-61 pubmed
    ..Our data suggest that HIV-1 infection alters the organization of pulmonary granulomas by modulating TNF and, possibly, cell trafficking, leading to an impaired anti-tuberculosis response...
  18. Moltyaner Y, Geerts W, Chamberlain D, Heyworth P, Noack D, Rae J, et al. Underlying chronic granulomatous disease in a patient with bronchocentric granulomatosis. Thorax. 2003;58:1096-8 pubmed
    ..We postulate that an ineffective immune response led to the prolonged colonisation of Afumigatus resulting in a hypersensitivity reaction that was manifest clinically as bronchocentric granulomatosis...
  19. Mocherla B, Kim J, Roayaie S, Kim S, Machac J, Kostakoglu L. FDG PET/CT imaging to rule out extrahepatic metastases before liver transplantation. Clin Nucl Med. 2007;32:947-8 pubmed
    ..FDG PET/CT imaging revealed multiple FDG-avid pulmonary nodules that were subsequently confirmed to represent Mycobacterium avium intracellular infection on histology...
  20. Le Guillou F, Hubscher P, Cuvelier A, Quieffin J, Guyonnaud C, El Haite A, et al. [Bilateral pleural thickening pseudo-tumour due to tuberculosis]. Rev Mal Respir. 2002;19:515-7 pubmed
    ..Tuberculous pleural disease is rarely bilateral and such presentation as a pseudo-tumour is very rare in Europe. Anatomically the pleural disease would seem to have been secondary to the vertebral disease as the result of direct spread...
  21. Hosaka N, Kameko M, Nishimura H, Hosaka S. Prevalence of tuberculosis in small pulmonary nodules obtained by video-assisted thoracoscopic surgery. Respir Med. 2006;100:238-43 pubmed
    ..The results of the present study suggested that even though the prevalence of lung tuberculosis is low, attention should be paid to the presence of M. tuberculosis in specimens obtained by VATS...
  22. Westhoff M, Welim B, Muller K. [Bronchocentric granulomatosis]. Pneumologie. 2005;59:804-10 pubmed
    ..This mostly requires surgical lung biopsy. With therapy -- either surgery or corticosteroid therapy or the combination of both -- the prognosis is good...
  23. Ehlers S. [Pathomorphogenesis of tubercular histologic changes: mechanisms of granuloma formation, maintenance and necrosis]. Internist (Berl). 2003;44:1363-73 pubmed
    ..g. administration of anti-TNF monoclonal antibodies, may result in reactivation of tuberculosis...
  24. Wallaert B. [Severe phenotypes in sarcoidosis pulmonary involvement]. Rev Prat. 2008;58:1072-6 pubmed
    ..Mycetomas may develop in cystic spaces and be responsible for severe haemoptysis. A better knowledge of these patterns is associated with a better management of severe sarcoidosis...
  25. Heinrich D, Gordjani N, Trusen A, Marx A, Hebestreit H. Necrotizing sarcoid granulomatosis: a rarity in childhood. Pediatr Pulmonol. 2003;35:407-11 pubmed
    ..However, because some characteristics of NSG are uncommon in typical sarcoidosis, NSG may also be an entity in its own right...
  26. Fenhalls G, Squires G, Stevens Muller L, Bezuidenhout J, Amphlett G, Duncan K, et al. Associations between toll-like receptors and interleukin-4 in the lungs of patients with tuberculosis. Am J Respir Cell Mol Biol. 2003;29:28-38 pubmed
    ..In conclusion, TLRs are expressed by various cell types in the human tuberculous lung, and their expression patterns are reflected by differences in the immune response...
  27. Bean A, Roach D, Briscoe H, France M, Korner H, Sedgwick J, et al. Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin. J Immunol. 1999;162:3504-11 pubmed
    ..Thus, the enhanced susceptibility of TNF-/- is not compensated for by the presence of LT alpha, and the critical role of TNF is not in the activation of T cells and macrophages but in the local organization of granulomas...
  28. Tajima S, Sando Y, Maeno T, Sagawa N, Nara M, Maeno Y, et al. Increased serum thymidine kinase activity in acute sarcoidosis. Intern Med. 2002;41:129-32 pubmed
    ..Its rise in sarcoidosis has, however, not been described. Because acute sarcoidosis sometimes resembles malignant lymphoma, the possible rise of serum TK in sarcoidosis may be worthy of note...
  29. Yang C, Teng J, Gu Y, Chen S. Takayasu's arteritis presenting with bilateral pulmonary granulomatosis. Clin Rheumatol. 2007;26:612-4 pubmed
    ..An open-lung biopsy showed characteristic changes of extra-vascular granulomatosis. To our knowledge, this has not been described previously in the literature...
  30. Ben Ghorbel I, Ennaifer R, Haouet S, Khanfir M, Lamloum M, Miled M, et al. [Pulmonary hyalinizing granuloma revealed by a pituitary gland diffusion]. Rev Med Interne. 2008;29:54-7 pubmed
    ..The extrapulmonary diffusion of the disease is extremely rare, and in our knowledge any case of pituitary diffusion has ever been reported in the literature...
  31. Hahtola P, Järvenpää R, Lounatmaa K, Mattila J, Rantala I, Uitti J, et al. Hard metal alveolitis accompanied by rheumatoid arthritis. Respiration. 2000;67:209-12 pubmed
    ..After the patient had quit working with hard metal and following corticosteroid therapy, pulmonary symptoms and signs were relieved. During this recovery period, however, she contracted rheumatoid arthritis...
  32. Torii A, Miyake M, Morishita M, Ito K, Torii S, Sakamoto T. Vitamin A reduces lung granulomatous inflammation with eosinophilic and neutrophilic infiltration in Sephadex-treated rats. Eur J Pharmacol. 2004;497:335-42 pubmed
    ..Vitamin A may inhibit Sephadex-induced lung granulomatous formation, and eosinophilic and neutrophilic infiltration due to its suppression of TNF-alpha and eotaxin production, and NF-kappaB activation...
  33. Ito T, Schaller M, Hogaboam C, Standiford T, Sandor M, Lukacs N, et al. TLR9 regulates the mycobacteria-elicited pulmonary granulomatous immune response in mice through DC-derived Notch ligand delta-like 4. J Clin Invest. 2009;119:33-46 pubmed publisher
    ..Furthermore, TLR9 seems to be required for optimal dll4 expression and the regulation of Mycobacterium antigen-elicited granuloma formation in mice...
  34. Fairhurst R, Pegues D. Images in clinical medicine. Pulmonary cryptococcal granulomas. N Engl J Med. 2002;347:497 pubmed
  35. Aly S, Laskay T, Mages J, Malzan A, Lang R, Ehlers S. Interferon-gamma-dependent mechanisms of mycobacteria-induced pulmonary immunopathology: the role of angiostasis and CXCR3-targeted chemokines for granuloma necrosis. J Pathol. 2007;212:295-305 pubmed
  36. Welsh K, Abbott A, Hwang S, Indrigo J, Armitige L, Blackburn M, et al. A role for tumour necrosis factor-alpha, complement C5 and interleukin-6 in the initiation and development of the mycobacterial cord factor trehalose 6,6'-dimycolate induced granulomatous response. Microbiology. 2008;154:1813-24 pubmed publisher
    ..These data suggest that TNF-alpha is critical for initiation of the granulomatous response, C5a is necessary for formation of cohesive granulomas, and IL-6 plays a key role in the granuloma maintenance response to mycobacterial TDM...
  37. Reddy C, Gupta A, Singh P, Mann S. Imaging of granulomatous and chronic invasive fungal sinusitis: comparison with allergic fungal sinusitis. Otolaryngol Head Neck Surg. 2010;143:294-300 pubmed publisher
    ..To study the radiological features of chronic/granulomatous invasive fungal sinusitis (IFS) and identify differentiating characteristics, if any, from allergic fungal sinusitis (AFS)...
  38. Satti M, Batouk A, Abdelaziz M, Ahmad M, Abdelaal M. Pulmonary hyalinizing granuloma. Bilateral pulmonary nodules associated with chronic idiopathic thrombocytopenic purpura. Saudi Med J. 2005;26:1459-63 pubmed
    ..The case is discussed with emphasis on the histological and radiological differential diagnosis, in addition to including ITP among the spectrum of immunologic conditions associated with PHG...
  39. Jakubzick C, Wen H, Matsukawa A, Keller M, Kunkel S, Hogaboam C. Role of CCR4 ligands, CCL17 and CCL22, during Schistosoma mansoni egg-induced pulmonary granuloma formation in mice. Am J Pathol. 2004;165:1211-21 pubmed
    ..Thus, these studies demonstrate a major role for CCL22 and a lesser role for CCL17 during an evolving S. mansoni egg granuloma in the lung...
  40. Fidvi S, Brudnicki A, Chowdhury M, Beneck D. Cavitary Rhodococcus equi pneumonia with endobronchial granulomas: report of an unusual case. Pediatr Radiol. 2003;33:140-2 pubmed
    ..An unusual case of cavitary Rhodococcus equi pneumonia with endobronchial granulomas in congenital HIV infection is presented. The clinical features and radiological manifestations of pulmonary R. equi infection are discussed...
  41. Abdelmoula S, Ben Brahim E, Lagha M, Kilani F, Touinsi H, Lassad Loussaief M, et al. [Sarcoid-like necrotizing granulomatosis. A case report]. Rev Pneumol Clin. 2002;58:351-4 pubmed
    ..The diagnosis was made only by open lung biopsy which showed histological findings of necrotizing sarcoid granulomatosis. The opacities disappeared with no recurrence spontaneously at one year...
  42. Madden B, Datta S, McAnulty G. Tracheal granulation tissue after percutaneous tracheostomy treated with Nd:Yag laser: three cases. J Laryngol Otol. 2001;115:743-4 pubmed
    ..Follow-up bronchoscopy showed no recurrence. Fibre-optic bronchoscopy at the time of tracheal decannulation may identify granulation tissue requiring appropriate referral and intervention...
  43. Chiaramonte M, Hesse M, Cheever A, Wynn T. CpG oligonucleotides can prophylactically immunize against Th2-mediated schistosome egg-induced pathology by an IL-12-independent mechanism. J Immunol. 2000;164:973-85 pubmed
    ..These findings illustrate the utility of CpG DNA as adjuvants for vaccines designed to prevent Th2-dependent immunopathology...
  44. Guirado E, Gordillo S, Gil O, Diaz J, Tapia G, Vilaplana C, et al. Intragranulomatous necrosis in pulmonary granulomas is not related to resistance against Mycobacterium tuberculosis infection in experimental murine models induced by aerosol. Int J Exp Pathol. 2006;87:139-49 pubmed
    ..Our work supports that INPG induction is a local phenomenon unrelated to the resistant (C57BL/6 and BALB/c) or susceptible (129/Sv and DBA/2) background of mice strains against M. tuberculosis infection...
  45. Churg A, Muller N, Flint J, Wright J. Chronic hypersensitivity pneumonitis. Am J Surg Pathol. 2006;30:201-8 pubmed
    ..Despite the presence of extensive fibrosis, some patients responded to removal from exposure and steroid therapy...
  46. Facco M, Baesso I, Miorin M, Bortoli M, Cabrelle A, Boscaro E, et al. Expression and role of CCR6/CCL20 chemokine axis in pulmonary sarcoidosis. J Leukoc Biol. 2007;82:946-55 pubmed
    ..In conclusion, T cells expressing CCR6, CXCR3, and CXCR6 act coordinately with respective ligands and Th1 inflammatory cytokines in the alveolitic/granuloma phases of the disease...
  47. Shinohara T, Kaneko T, Miyazawa N, Nakatani Y, Nishiyama H, Shoji A, et al. Pulmonary hyalinizing granuloma with laryngeal and subcutaneous involvement: report of a case successfully treated with glucocorticoids. Intern Med. 2004;43:69-73 pubmed
    ..Although there is no established treatment for PHG, the laryngeal tumor was diminished and all other lesions disappeared with glucocorticoid treatment...
  48. Benaixa J, Esteban F, González Pérez J, Martínez Garrido R. [Treatment of laryngeal granuloma with anti-extraesophageal reflux medication]. Acta Otorrinolaringol Esp. 2003;54:501-5 pubmed
    ..To asses the role of Gastroesophageal reflux in the genesis of laryngeal granulomas...
  49. Kaplan G, Post F, Moreira A, Wainwright H, Kreiswirth B, Tanverdi M, et al. Mycobacterium tuberculosis growth at the cavity surface: a microenvironment with failed immunity. Infect Immun. 2003;71:7099-108 pubmed
  50. Warheit D, Laurence B, Reed K, Roach D, Reynolds G, Webb T. Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol Sci. 2004;77:117-25 pubmed
    ..Thus, the physiological relevance of these findings should ultimately be determined by conducting an inhalation toxicity study...
  51. Duckett S, Kradin R, Galle P. The pathogenesis of beryllium-induced pulmonary granulomatosis. A scanning secondary ion analytical microscopy study. C R Acad Sci III. 2000;323:769-74 pubmed
    ..These findings raise the question as to whether pulmonary granulomatous lesions of other origins are also localized within the vascular wall...
  52. Lee S, Lee S, Yang S, Yoo C, Kim Y, Shim Y, et al. A case of granulomatous lung disease in a patient with Good's syndrome. Korean J Intern Med. 2008;23:219-22 pubmed publisher
    ..Clinicians should look for evidence of immunologic dysfunction in thymoma patients presenting with severe recurrent infections, especially opportunistic infections...
  53. Andersson J, Isberg B, Christensson B, Veress B, Linde A, Bratel T. Interferon gamma (IFN-gamma) deficiency in generalized Epstein-Barr virus infection with interstitial lymphoid and granulomatous pneumonia, focal cerebral lesions, and genital ulcers: remission following IFN-gamma substitution therapy. Clin Infect Dis. 1999;28:1036-42 pubmed
    ..These findings provide evidence for an EBV-induced lymphoproliferative disorder due to a T lymphocyte dysfunction associated with a selective lack of IFN-gamma synthesis...