plasma cell granuloma

Summary

Summary: A slow-growing benign pseudotumor in which plasma cells greatly outnumber the inflammatory cells.

Top Publications

  1. Akbulut M, Gunhan Bilgen I, Zekioglu O, Duygulu G, Oktay A, Ozdemir N. Fine needle aspiration cytology of inflammatory myofibroblastic tumour (inflammatory pseudotumour) of the breast: a case report and review of the literature. Cytopathology. 2007;18:384-7 pubmed
  2. Mahendra G, Pandit H, Kliskey K, Murray D, Gill H, Athanasou N. Necrotic and inflammatory changes in metal-on-metal resurfacing hip arthroplasties. Acta Orthop. 2009;80:653-9 pubmed publisher
    ..The precise frequency and significance of these tissue changes is unknown...
  3. Tomiyama M, Nakatani S, Ishibashi Ueda H, Yutani C, Yamagishi M. Inflammatory pseudotumor of the heart. Ann Intern Med. 2007;147:351-2 pubmed
  4. Kwon Y, Glyn Jones S, Simpson D, Kamali A, McLardy Smith P, Gill H, et al. Analysis of wear of retrieved metal-on-metal hip resurfacing implants revised due to pseudotumours. J Bone Joint Surg Br. 2010;92:356-61 pubmed publisher
    ..Furthermore, edge-loading with the loss of fluid-film lubrication may be an important mechanism of generation of wear in patients with a pseudotumour...
  5. Deniz K, Patiroglu T, Okten T. Plasma cell granuloma of the thyroid. APMIS. 2008;116:167-72 pubmed publisher
    We report two cases of thyroidal plasma cell granuloma. Both patients underwent surgical resection after presenting with painless neck swelling...
  6. Burke A, Li L, Kling E, Kutys R, Virmani R, Miettinen M. Cardiac inflammatory myofibroblastic tumor: a "benign" neoplasm that may result in syncope, myocardial infarction, and sudden death. Am J Surg Pathol. 2007;31:1115-22 pubmed
    ..These cardiac myofibroblastic tumors are readily distinguished from other endocardial-based cardiac tumors, including papillary fibroelastoma and myxoma, which may present clinically in the same manner...
  7. Tian J, Cheng L, Yung T. Multiple cardiac inflammatory myofibroblastic tumors in the right ventricle in an infant. Ann Thorac Surg. 2006;82:1531-5 pubmed
    ..In this report we review the relevant literature and discuss the prevalence, histology, pathogenesis, clinical manifestations, diagnosis, differential diagnosis, and treatment of cardiac inflammatory myofibroblastic tumor...
  8. Pandit H, Glyn Jones S, McLardy Smith P, Gundle R, Whitwell D, Gibbons C, et al. Pseudotumours associated with metal-on-metal hip resurfacings. J Bone Joint Surg Br. 2008;90:847-51 pubmed publisher
    ..We are concerned that with time the incidence of these pseudotumours may increase. Further investigation is required to define their cause...
  9. Su J, Caleb M, Tan R, Low A, Lim C. Cardiac inflammatory myofibroblastic tumor as a rare cause of aortic regurgitation: a case report. J Thorac Cardiovasc Surg. 2006;132:150-1 pubmed

More Information

Publications62

  1. Clayton R, Beggs I, Salter D, Grant M, Patton J, Porter D. Inflammatory pseudotumor associated with femoral nerve palsy following metal-on-metal resurfacing of the hip. A case report. J Bone Joint Surg Am. 2008;90:1988-93 pubmed publisher
  2. Khanafshar E, Phillipson J, Schammel D, Minobe L, Cymerman J, Weidner N. Inflammatory myofibroblastic tumor of the breast. Ann Diagn Pathol. 2005;9:123-9 pubmed
  3. Harvie P, Giele H, Fang C, Ansorge O, Ostlere S, Gibbons M, et al. The treatment of femoral neuropathy due to pseudotumour caused by metal-on-metal resurfacing arthroplasty. Hip Int. 2008;18:313-20 pubmed
    ..Prolonged follow-up and detailed clinical assessment of patients after hip resurfacing arthroplasty is advocated with planned and expeditious revision of any patient in whom evidence of femoral neuropathy develops...
  4. Zen Y, Kasahara Y, Horita K, Miyayama S, Miura S, Kitagawa S, et al. Inflammatory pseudotumor of the breast in a patient with a high serum IgG4 level: histologic similarity to sclerosing pancreatitis. Am J Surg Pathol. 2005;29:275-8 pubmed
    ..IgG4 might become a useful marker for inflammatory pseudotumor of the breast, and it might benefit from steroid therapy, as does sclerosing pancreatitis...
  5. Kriegl L, Guetgemann I, Zhou H. Plasma cell granuloma of the thyroid gland mimicking carcinoma: a case report and review of the literature. Pathol Res Pract. 2007;203:813-7 pubmed
    ..This is the first case in which molecular pathological analyses for EBV and HHV8 DNA were made. As these were negative, distinct etiological features were suggested...
  6. Gleason B, Hornick J. Inflammatory myofibroblastic tumours: where are we now?. J Clin Pathol. 2008;61:428-37 pubmed
    ..This review will examine the clinical, pathological, and molecular genetic features of IMT and discuss an approach to diagnosis and differential diagnosis...
  7. Ilvan S, Celik V, Paksoy M, Cetinaslan I, Calay Z. Inflammatory myofibroblastic tumor (inflammatory pseudotumor) of the breast. APMIS. 2005;113:66-9 pubmed
    ..Here we describe a case of inflammatory myofibroblastic tumor of the breast in a 60-year-old woman. This is only the eleventh case reported in the English language literature. The patient was free of disease 85 months after surgery...
  8. Karthikeyan B, Pradeep A. Plasma cell granuloma of gingiva. Indian J Dent Res. 2004;15:114-6 pubmed
    An exceedingly rare case of gingival plasma cell granuloma is reported in a 40-year old female patient. The case presented as an exophytic mass of gingiva, clinically resembling traumatic fibroma...
  9. Yao X, Alvarado Y, Brackeen J, Jumper C, Cobos E. Plasma cell granuloma: a case report of multiple lesions in the lung and review of the literature. Am J Med Sci. 2007;334:402-6 pubmed
    Although plasma cell granuloma is a rare tumor in the lung, it must be considered in the differential diagnosis of lung cancer. It typically presents as a solitary lesion...
  10. Fontenot J, Levine S, Adegboyega P, Cotelingam J. Plasma cell granuloma of the thyroid: report of case and review of literature. Endocr Pract. 2008;14:611-7 pubmed
    To report the 12th case of a patient with a plasma cell granuloma of the thyroid, a rare cause of goiter and hypothyroidism.
  11. Megremis S, Papamitsaki E, Ieromonachou P, Zois E. Inflammatory myofibroblastic tumor of the paratestis: sonographic appearance with pathologic correlation. J Ultrasound Med. 2007;26:1227-30 pubmed
  12. Pandit H, Vlychou M, Whitwell D, Crook D, Luqmani R, Ostlere S, et al. Necrotic granulomatous pseudotumours in bilateral resurfacing hip arthoplasties: evidence for a type IV immune response. Virchows Arch. 2008;453:529-34 pubmed publisher
  13. Kim S, Eom D, Huh J, Sung I, Choi I, Ryu S, et al. Plasma cell granuloma in cyclosporine-induced gingival overgrowth: a report of two cases with immunohistochemical positivity of interleukin-6 and phospholipase C-gamma1. J Korean Med Sci. 2002;17:704-7 pubmed
    We report two cases of gingival plasma cell granuloma in a 34-yr-old and 40-yr-old two male renal transplant recipients with cyclosporine A (CsA)-induced gingival overgrowth (GO)...
  14. Lu C, Chen C, Hsia C, Chiang J, Tsay S, Han H, et al. A progressive growing inflammatory pseudotumor of the liver. Zhonghua Yi Xue Za Zhi (Taipei). 2001;64:725-30 pubmed
    ..5 cm to 10.0 cm in diameter within 8 months. He underwent a right lobectomy of the liver, and the final diagnosis was proven by pathology. There were no complications in the post-operative course...
  15. Sastre Garau X, Couturier J, Derré J, Aurias A, Klijanienko J, Lagace R. Inflammatory myofibroblastic tumour (inflammatory pseudotumour) of the breast. Clinicopathological and genetic analysis of a case with evidence for clonality. J Pathol. 2002;196:97-102 pubmed
    ..2p22.2), +7, del(9)(p23), +19. Including the present observation, a 9p deletion has now been found in three cases of IMT. These observations show that IMT may be a clonal neoplasm, even in sites different from deep soft tissues...
  16. Ferrer García J, Costa Talens P, Merino Torres J, Prieto Rodriguez M, Vera Sempere J, Pinon Selles F. Plasma cell granuloma of the thyroid and Hashimoto thyroiditis. South Med J. 2004;97:598-600 pubmed
    b>Plasma cell granuloma of the thyroid is a rare tumor-like lesion formed by a localized proliferation of inflammatory cells, supported by a stroma of fibrous tissue. Few cases have been previously reported in the medical literature...
  17. Krishna L, Ng W, Chachlani N. Inflammatory pseudotumor of the heart causing aortic regurgitation. Ann Thorac Surg. 2001;71:1361-3 pubmed
    ..The lesion was excised and the aortic valve was replaced, resulting in a favorable outcome for the patient...
  18. Buccoliero A, Caldarella A, Santucci M, Ammannati F, Mennonna P, Taddei A, et al. Plasma cell granuloma--an enigmatic lesion: description of an extensive intracranial case and review of the literature. Arch Pathol Lab Med. 2003;127:e220-3 pubmed
    We present an unusual case of intracranial plasma cell granuloma in a 70-year-old man with a 6-month history of progressive visual disturbance...
  19. Mugler K, Gaido L, Ryder J, Said S. Plasma cell granuloma of the thyroid with Hashimoto's thyroiditis: report of a rare case. Ear Nose Throat J. 2003;82:64-6 pubmed
    As only eight cases have been previously reported in the literature, plasma cell granuloma of the thyroid gland is a rare entity. This condition can be confused with a benign or malignant neoplastic thyroid process...
  20. Lee S. Fine-needle aspiration cytology of splenic hamartoma. Diagn Cytopathol. 2003;28:82-5 pubmed
    ..A combination of cytologic features and immunopathologic results from the aspirate cytoblock along with the salient clinical information should enable an accurate preoperative diagnosis of splenic hamartoma...
  21. Martinez F, Filipowicz E, Hudnall S. Plasma cell granuloma of the thyroid. Arch Pathol Lab Med. 2002;126:595-8 pubmed
    b>Plasma cell granuloma of the thyroid is an uncommon lesion; only 6 cases have been reported in the English literature to date. All reported cases occurred in women, mostly after the age of 50 years...
  22. Greiner C, Rickert C, Möllmann F, Rieger B, Semik M, Heindel W, et al. Plasma cell granuloma involving the brain and the lung. Acta Neurochir (Wien). 2003;145:1127-31 pubmed
    ..Symptomatic plasma cell granulomas (PCG) of the central nervous system (CNS) are a rare entity, especially in association with an extracranial manifestation...
  23. Cheuk W, Woo P, Yuen K, Yu P, Chan J. Intestinal inflammatory pseudotumour with regional lymph node involvement: identification of a new bacterium as the aetiological agent. J Pathol. 2000;192:289-92 pubmed
    ..The importance of searching for an infective agent in inflammatory pseudotumour in the appropriate setting is re-emphasized...
  24. Choi S, Choi Y, Cheon S, Byun Y, Cho S. Inflammatory pseudotumor of the urinary bladder in a child. Yonsei Med J. 2000;41:401-3 pubmed
    ..It is a benign proliferative lesion of the submucosal stroma easily mistaken for a sarcoma clinically, so it should be differentiated from a malignant neoplasm. We report the case of bladder inflammatory pseudotumor in a 7-year-old girl...
  25. Kapur P, Treat K, Chuang A, Hoang M. Pathologic quiz case: paratesticular mass in a young man. Inflammatory myofibroblastic tumor of the paratestis. Arch Pathol Lab Med. 2004;128:589-90 pubmed
  26. Kaneko K, Ando H, Watanabe Y, Seo T, Nagino M, Kamiya J, et al. Aggressive preoperative management and extended surgery for inflammatory pseudotumor involving the hepatic hilum in a child. Surgery. 2001;129:757-60 pubmed
    ..3)..
  27. Peacock M, Hokett S, Hellstein J, Herold R, Matzenbacher S, Scales D, et al. Gingival plasma cell granuloma. J Periodontol. 2001;72:1287-90 pubmed
    ..for kappa and lambda light chains showed a polyclonal staining pattern confirming a diagnosis of plasma cell granuloma. Intraoral plasma cell granuloma is exceedingly rare, although case reports documenting such lesions have ..
  28. Narla L, Newman B, Spottswood S, Narla S, Kolli R. Inflammatory pseudotumor. Radiographics. 2003;23:719-29 pubmed
    ..Because inflammatory pseudotumors mimic malignant tumors both clinically and radiologically, the radiologist should be familiar with this entity and help avoid unnecessary radical surgery when possible...
  29. Lee S, Fang Y, Luo J, Kuo H, Chen H. Inflammatory pseudotumour associated with chronic persistent Eikenella corrodens infection: a case report and brief review. J Clin Pathol. 2003;56:868-70 pubmed
    ..It is of paramount importance that clinicians search for an infective cause of an inflammatory pseudotumour, to ensure appropriate treatment...
  30. Despeyroux Ewers M, Catalaa I, Collin L, Cognard C, Loubes Lacroix F, Manelfe C. Inflammatory myofibroblastic tumour of the spinal cord: case report and review of the literature. Neuroradiology. 2003;45:812-7 pubmed
    ..Pial lesions on the lumbar enlargement and thoracic spinal were present 11 months after surgery, when the lesion recurred. We present the radiological, operative and pathological findings and review the literature...
  31. Freeman A, Geddes N, Munson P, Joseph J, Ramani P, Sandison A, et al. Anaplastic lymphoma kinase (ALK 1) staining and molecular analysis in inflammatory myofibroblastic tumours of the bladder: a preliminary clinicopathological study of nine cases and review of the literature. Mod Pathol. 2004;17:765-71 pubmed
    ..In conclusion, ALK 1 staining may be of value in the distinction of vesical IMFT from morphologically similar entities, and often reflects ALK gene translocations in these lesions...
  32. Lawrence B, Perez Atayde A, Hibbard M, Rubin B, Dal Cin P, Pinkus J, et al. TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors. Am J Pathol. 2000;157:377-84 pubmed
    ..Notably, a TPM3-ALK oncogene was reported recently in anaplastic lymphoma, and TPM3-ALK is thereby the first known fusion oncogene that transforms, in vivo, both mesenchymal and lymphoid human cell lineages...
  33. Sanders B, West K, Gingalewski C, Engum S, Davis M, Grosfeld J. Inflammatory pseudotumor of the alimentary tract: clinical and surgical experience. J Pediatr Surg. 2001;36:169-73 pubmed
    ..This report details the clinical and surgical experiences in 4 children with alimentary tract IPT at a single institution...
  34. Li Voon Chong J, Burrows C, Cave Bigley D, MacFarlane I. A hard thyroid mass due to plasma cell granuloma. Int J Clin Pract. 2001;55:335-6 pubmed
    b>Plasma cell granuloma involving the thyroid is very rare. A 29-year-old man with type 1 diabetes mellitus presented with a one-week history of fever, sore throat, neck tenderness and dysphagia...
  35. Torzilli G, Inoue K, Midorikawa Y, Hui A, Takayama T, Makuuchi M. Inflammatory pseudotumors of the liver: prevalence and clinical impact in surgical patients. Hepatogastroenterology. 2001;48:1118-23 pubmed
    ..To estimate their prevalence and clinical impact in surgical series we evaluate retrospectively our experience...
  36. Koea J, Broadhurst G, Rodgers M, McCall J. Inflammatory pseudotumor of the liver: demographics, diagnosis, and the case for nonoperative management. J Am Coll Surg. 2003;196:226-35 pubmed
    ..Inflammatory pseudotumor of the liver (IPL) is an unusual tumor-like condition that is becoming recognized as an important differential diagnosis in the patient presenting with liver masses. This report describes six cases of IPL...
  37. Haj M, Weiss M, Loberant N, Cohen I. Inflammatory pseudotumor of the breast: case report and literature review. Breast J. 2003;9:423-5 pubmed
    ..The aim of this report is to describe the clinical, imaging, and pathologic features in a case of breast IP, the first reported case in a postpartum woman still nursing her infant...
  38. Laurent S, Mouthon L, Longchampt E, Roudaire M, Franc S, Krivitzky A, et al. Medical cure of plasma cell granuloma of the thyroid associated with Hashimoto's thyroiditis: a case report and review. J Clin Endocrinol Metab. 2004;89:1534-7 pubmed
    b>Plasma cell granuloma (PCG) is a rare, benign inflammatory tumor composed of myofibroblasts, abundant plasma cells, and lymphocytes combined with collagen...
  39. Shintaku M, Ukikusa M. Proliferative funiculitis with a prominent infiltration of mast cells. Pathol Int. 2003;53:897-900 pubmed
    ..The present case is the first example of proliferative funiculitis associated with this rare phenomenon...
  40. Kapusta L, Weiss M, Ramsay J, Lopez Beltran A, Srigley J. Inflammatory myofibroblastic tumors of the kidney: a clinicopathologic and immunohistochemical study of 12 cases. Am J Surg Pathol. 2003;27:658-66 pubmed
    ..Based on this series, renal inflammatory myofibroblastic tumor is a proliferative lesion of myofibroblasts of uncertain pathogenesis with no identified potential for recurrence or metastases...
  41. Brittig F, Ajtay E, Jáksó P, Kelényi G. Follicular dendritic reticulum cell tumor mimicking inflammatory pseudotumor of the spleen. Pathol Oncol Res. 2004;10:57-60 pubmed
    ..The FDRCs of the lesion and a few smaller spindle cells were EBER positive indicative of the presence of EBV. No EBER positive cells were seen in the uninvolved spleen...
  42. Perez Lopez C, Gutierrez M, Isla A. Inflammatory pseudotumor of the median nerve. Case report and review of the literature. J Neurosurg. 2001;95:124-8 pubmed
    ..The follow-up period has been 8 years. The cause of the lesion is unknown. The differential diagnosis includes benign and malignant peripheral nerve-sheath tumors, lymphoma, and all tumorlike lesions of peripheral nerves...
  43. Chan Tack K, Chengappa K, Wolf J, Kao G, Reisler R. Immune reconstitution inflammatory syndrome presenting as sinusitis with inflammatory pseudotumor in an HIV-infected patient: a case report and review of the literature. AIDS Patient Care STDS. 2006;20:823-8 pubmed
    ..Malignancies, such as Kaposi's sarcoma, have also been reported. We report a case of sinusitis with presumptive inflammatory pseudotumor as a manifestation of IRIS that occurred 20 weeks after the initiation of HAART...
  44. Bel Haj Salah M, Ben Haha Bellil S, Bellil K, Mekni A, Chelly I, Kchir N, et al. [A rare subcutaneous tumour]. Ann Pathol. 2006;26:283-4 pubmed
  45. Lioulias A, Misthos P, Neofotistos K, Legaki S. Primary myofibrosarcoma of the lung. A rare case with challenging diagnosis. J BUON. 2009;14:143-5 pubmed
    ..He underwent left pneumonectomy and died on the 6th postoperative month. This is the second case of primary pulmonary MFS to be reported...
  46. Wick M, Patterson J. Selected pseudoneoplastic lesions of the skin. Arch Pathol Lab Med. 2010;134:369-77 pubmed publisher
    ..Pseudoneoplastic cutaneous lesions are diverse, not only morphologically but also with respect to their causes and cellular lineages. They include proliferations of epithelial, as well as mesenchymal, elements...
  47. Cassidy F, Ishioka K, McMahon C, Chu P, Sakamoto K, Lee K, et al. MR imaging of scrotal tumors and pseudotumors. Radiographics. 2010;30:665-83 pubmed publisher
    ..Normal scrotal MR anatomic features and optimal MR imaging technique are also presented...
  48. Huellner M, Schwizer B, Burger I, Fengels I, Schläpfer R, Bussmann C, et al. Inflammatory pseudotumor of the lung with high FDG uptake. Clin Nucl Med. 2010;35:722-3 pubmed publisher
    ..Bronchoscopy with transbronchial biopsies failed to deliver a conclusive diagnosis. Lobectomy was performed, and histopathology presented an inflammatory myofibroblastic pseudotumor...
  49. Brcic I, Brcic L, Hutinec Z, Prgomet D, Seiwerth S. Laryngeal inflammatory myofibroblastic tumor in a man: a case report. Coll Antropol. 2010;34:1127-9 pubmed
    ..It is known under a wide number of terms, such as inflammatory pseudotumor, plasma cell granuloma, pseudosarcomatous myofibroblastic proliferation...
  50. Shi H, Wei L, Sun L, Guo A. Primary gastric inflammatory myofibroblastic tumor: a clinicopathologic and immunohistochemical study of 5 cases. Pathol Res Pract. 2010;206:287-91 pubmed publisher
    ..Our results indicate that primary gastric IMTs have an intermediate behavior as seen at other sites...
  51. Nawashiro H, Omura T, Kobayashi H. Cystic intracranial plasma cell granuloma. J Neurosurg. 2006;105:799; author reply 799-800 pubmed
  52. Park K, Jang B, Chung W, Cho K, Hwang J, Kang Y, et al. [Inflammatory pseudotumor of liver--a clinical review of 15 cases]. Korean J Hepatol. 2006;12:429-38 pubmed
    ..We aimed to elucidate the characteristic features of this disease entity by analyzing our experiences and by reviewing the related literatures...
  53. Xu H, Liu G, Lu M, Xie X, Xu Z, Zheng Y, et al. Characterization of small focal liver lesions using real-time contrast-enhanced sonography: diagnostic performance analysis in 200 patients. J Ultrasound Med. 2006;25:349-61 pubmed
    ..The purpose of this study was to assess the diagnostic performance of real-time contrast-enhanced sonography in characterization of small focal liver lesions (FLLs; < or = 3.0 cm in diameter)...