elephantiasis

Summary

Summary: Hypertrophy and thickening of tissues from causes other than filarial infection, the latter being described as ELEPHANTIASIS, FILARIAL.

Top Publications

  1. Kuepper D. Giant scrotal elephantiasis. Urology. 2005;65:389 pubmed
    How much can a man carry? Penoscrotal elephantiasis is a debilitating syndrome. This is a case report of a patient with giant genital elephantiasis secondary to long-standing lymphogranuloma venereum infection in Ethiopia...
  2. Nelson R, Alberts G, King L. Penile and scrotal elephantiasis caused by indolent Chlamydia trachomatis infection. Urology. 2003;61:224 pubmed
    Isolated penile and scrotal elephantiasis presents a diagnostic and therapeutic challenge. We report a case of chronic penile and scrotal elephantiasis caused by indolent Chlamydia trachomatis infection...
  3. Davey G. Podoconiosis, non-filarial elephantiasis, and lymphology. Lymphology. 2010;43:168-77 pubmed
    ..Finally, prevention and treatment will be described and the need for operational research to optimize community-based interventions outlined. ..
  4. Tora A, Davey G, Tadele G. Factors related to discontinued clinic attendance by patients with podoconiosis in southern Ethiopia: a qualitative study. BMC Public Health. 2012;12:902 pubmed publisher
    ..Appropriate routes to deliver this information must be identified. Certain factors (such as distance to clinic sites and stigma) require substantial expansion of services or liaison with village-level government health services. ..
  5. Korevaar D, Visser B. Podoconiosis, a neglected tropical disease. Neth J Med. 2012;70:210-4 pubmed
    Podoconiosis or 'endemic non-filarial elephantiasis' is a tropical disease caused by exposure of bare feet to irritant alkaline clay soils. This causes an asymmetrical swelling of the feet and lower limbs due to lymphoedema...
  6. Tomczyk S, Tamiru A, Davey G. Addressing the neglected tropical disease podoconiosis in Northern Ethiopia: lessons learned from a new community podoconiosis program. PLoS Negl Trop Dis. 2012;6:e1560 pubmed publisher
    Despite its great public health importance, few control initiatives addressing podoconiosis (non-filarial elephantiasis, a geochemical neglected tropical disease) exist...
  7. Ryan T. Elephantiasis, elastin, and chronic wound healing: 19th century and contemporary viewpoints relevant to hypotheses concerning lymphedema, leprosy, erysipelas, and psoriasis--review and reflections. Lymphology. 2009;42:19-25 pubmed
    ..These are not new observations, and the writings of Unna and Kaposi are recalled. The contemporary observations on elastin by Gerli and his team are discussed in the light of these much earlier opinions...
  8. Gupta S, Ajith C, Kanwar A, Sehgal V, Kumar B, Mete U. Genital elephantiasis and sexually transmitted infections - revisited. Int J STD AIDS. 2006;17:157-65; quiz 166 pubmed
    Genital elephantiasis is an important medical problem in the tropics. It usually affects young and productive age group, and is associated with physical disability and extreme mental anguish...
  9. Geshere Oli G, Tekola Ayele F, Petros B. Parasitological, serological and clinical evidence for high prevalence of podoconiosis (non-filarial elephantiasis) in Midakegn district, central Ethiopia. Trop Med Int Health. 2012;17:722-6 pubmed publisher
    To determine whether the elephantiasis in Midakegn district, central Ethiopia, is filarial or non-filarial (podoconiosis) using serological, parasitological and clinical examinations, and to estimate its prevalence...

More Information

Publications62

  1. Iwao F, Sato Matsumura K, Sawamura D, Shimizu H. Elephantiasis nostras verrucosa successfully treated by surgical debridement. Dermatol Surg. 2004;30:939-41 pubmed
    b>Elephantiasis nostras verrucosa represents a rare group of cutaneous changes comprising dermal fibrosis, hyperkeratotic, verrucous, and papillomatous lesions after chronic secondary, nonfilarial lymphedema...
  2. Sarkar R, Kaur C, Thami G, Kanwar A. Genital elephantiasis. Int J STD AIDS. 2002;13:427-9 pubmed
    Genital elephantiasis (esthiomene), which is the dramatic end-result of lymphatic obstruction, is rather rare...
  3. Molla Y, Tomczyk S, Amberbir T, Tamiru A, Davey G. Patients' perceptions of podoconiosis causes, prevention and consequences in East and West Gojam, Northern Ethiopia. BMC Public Health. 2012;12:828 pubmed publisher
    Podoconiosis is a form of non-filarial elephantiasis that affects barefoot individuals in highland tropical areas. The disease presents with bilateral, asymmetric swelling of the legs, usually confined to below the knee...
  4. Yakob B, Deribe K, Davey G. Health professionals' attitudes and misconceptions regarding podoconiosis: potential impact on integration of care in southern Ethiopia. Trans R Soc Trop Med Hyg. 2010;104:42-7 pubmed publisher
    Offering long-term community care for patients with podoconiosis (endemic non-filarial elephantiasis) is challenging, and requires co-operation between patients and their families, the community and health care professionals...
  5. Yakob B, Deribe K, Davey G. High levels of misconceptions and stigma in a community highly endemic for podoconiosis in southern Ethiopia. Trans R Soc Trop Med Hyg. 2008;102:439-44 pubmed publisher
    ..Podoconiosis (endemic non-filarial elephantiasis) is a considerable public health problem in Ethiopia, yet little is known about community understanding of it...
  6. Davey G, Newport M. Podoconiosis: the most neglected tropical disease?. Lancet. 2007;369:888-9 pubmed
  7. Carlson J, Mazza J, Kircher K, Tran T. Otophyma: a case report and review of the literature of lymphedema (elephantiasis) of the ear. Am J Dermatopathol. 2008;30:67-72 pubmed publisher
    ..Literature review examining for cases of lymphedema (elephantiasis) of the ear revealed that chronic inflammatory disorders (rosacea (most frequent), psoriasis, eczema), ..
  8. Ayode D, McBride C, De Heer H, Watanabe E, Gebreyesus T, Tadele G, et al. The association of beliefs about heredity with preventive and interpersonal behaviors in communities affected by podoconiosis in rural Ethiopia. Am J Trop Med Hyg. 2012;87:623-30 pubmed publisher
    ..Culturally informed education programs that increase the perceived controllability of stigmatized hereditary health conditions like podoconiosis have promise for increasing preventive behaviors and reducing interpersonal stigma. ..
  9. Tekola F, Bull S, Farsides B, Newport M, Adeyemo A, Rotimi C, et al. Impact of social stigma on the process of obtaining informed consent for genetic research on podoconiosis: a qualitative study. BMC Med Ethics. 2009;10:13 pubmed publisher
    ..This involves understanding the issues in the society, the culture, community dialogues and developing a consent process that takes all these into consideration. ..
  10. Tammer M, Plogmeier K, Schneider W. [Surgical therapy of scrotal edema in elephantiasis congenita hereditaria (Meige type)]. Urologe A. 2002;41:493-5 pubmed
    ..We report on a surgical technique for treating pronounced scrotal edema by resection and neoscrotal reconstruction using ventral pedunculated scrotal skin flaps in cases of congenital hereditary elephantiasis of the Meige type.
  11. Stewart F, Treves N. Lymphangiosarcoma in postmastectomy lymphedema; a report of six cases in elephantiasis chirurgica. Cancer. 1948;1:64-81 pubmed
  12. Henok L, Davey G. Validation of the Dermatology Life Quality Index among patients with podoconiosis in southern Ethiopia. Br J Dermatol. 2008;159:903-6 pubmed publisher
    Podoconiosis is a geochemical elephantiasis common among subsistence farmers in Ethiopia. It is completely preventable but, untreated, leads to considerable physical disability, social stigma and economic disadvantage...
  13. Davey G, Tekola F, Newport M. Podoconiosis: non-infectious geochemical elephantiasis. Trans R Soc Trop Med Hyg. 2007;101:1175-80 pubmed
    ..epidemiology, genetics, ecology, pathogenesis, pathology and management of podoconiosis (endemic non-filarial elephantiasis)...
  14. Franklin H, Tora A, Deribe K, Reda A, Davey G. Development of a scale to measure stigma related to podoconiosis in Southern Ethiopia. BMC Public Health. 2013;13:298 pubmed publisher
    ..The scales will enable an evidence-based approach to mitigating stigma which will enable implementation of more effective disease control and help break the cycle of poverty and NTDs. ..
  15. Sisto K, Khachemoune A. Elephantiasis nostras verrucosa: a review. Am J Clin Dermatol. 2008;9:141-6 pubmed
    b>Elephantiasis nostras verrucosa (ENV) is a rare and dramatic sequela of chronic nonfilarial lymphedema. The condition is characterized by papules, verrucous lesions, enlargement, and woody fibrosis of the affected area...
  16. Addisu S, El Metwally T, Davey G, Worku Y, Titheradge M. The role of transforming growth factor-beta1 and oxidative stress in podoconiosis pathogenesis. Br J Dermatol. 2010;162:998-1003 pubmed publisher
    Podoconiosis (endemic nonfilarial elephantiasis) occurs in susceptible individuals who go barefoot in regions of irritant volcanic soil...
  17. Animut A. The burden of non-filarial elephantiasis in Ethiopia. Trans R Soc Trop Med Hyg. 2007;101:1173-4 pubmed
    Although known for many years, non-filarial elephantiasis remains a public health problem in tropical Africa, including the farming community of Ethiopia...
  18. Hornberger B, Elmore J, Roehrborn C. Idiopathic scrotal elephantiasis. Urology. 2005;65:389 pubmed
    Scrotal lymphedema (scrotal elephantiasis) is a condition that has historically been described in areas endemic to filariasis. We present a unique case of a 22-year-old man with idiopathic lymphedema isolated to the scrotum...
  19. Desta K, Ashine M, Davey G. Predictive value of clinical assessment of patients with podoconiosis in an endemic community setting. Trans R Soc Trop Med Hyg. 2007;101:621-3 pubmed
    Podoconiosis is a geochemical condition resulting in lower limb elephantiasis similar to that seen in chronic filarial disease...
  20. Nenoff P, Simon J, Muylowa G, Davey G. Podoconiosis - non-filarial geochemical elephantiasis - a neglected tropical disease?. J Dtsch Dermatol Ges. 2010;8:7-14 pubmed publisher
    Podoconiosis or mossy foot is a form of non-filarial lymphedema. This geochemical elephantiasis is a disabling condition caused by the passage of microparticles of silica and aluminum silicates through the skin of people walking barefoot ..
  21. Tekola F, Mariam D, Davey G. Economic costs of endemic non-filarial elephantiasis in Wolaita Zone, Ethiopia. Trop Med Int Health. 2006;11:1136-44 pubmed
    Endemic non-filarial elephantiasis or podoconiosis is a chronic and debilitating geochemical disease occurring in individuals exposed to red clay soil derived from alkalic volcanic rock...
  22. Tekola Ayele F, Adeyemo A, Finan C, Hailu E, Sinnott P, Burlinson N, et al. HLA class II locus and susceptibility to podoconiosis. N Engl J Med. 2012;366:1200-8 pubmed publisher
    ..Funded by the Wellcome Trust and others.). ..
  23. Molla Y, Tomczyk S, Amberbir T, Tamiru A, Davey G. Podoconiosis in East and West Gojam Zones, northern Ethiopia. PLoS Negl Trop Dis. 2012;6:e1744 pubmed publisher
    ..Predominance of cases at early clinical stage of podoconiosis indicates the potential for reversing the swelling and calls for disease prevention interventions. ..
  24. Zacharakis E, Dudderidge T, Zacharakis E, Ioannidis E. Surgical repair of idiopathic scrotal elephantiasis. South Med J. 2008;101:208-10 pubmed publisher
    Scrotal lymphedema (scrotal elephantiasis) is uncommon outside of filariasis endemic regions. We present a case of a 65-year-old with idiopathic lymphedema of the scrotum and functional impairment of the penis...
  25. Davey G, Gebrehanna E, Adeyemo A, Rotimi C, Newport M, Desta K. Podoconiosis: a tropical model for gene-environment interactions?. Trans R Soc Trop Med Hyg. 2007;101:91-6 pubmed
    Podoconiosis (endemic non-filarial elephantiasis) is a geochemical disease occurring in individuals exposed to red clay soil derived from alkalic volcanic rock...
  26. Wanji S, Tendongfor N, Esum M, Che J, Mand S, Tanga Mbi C, et al. Elephantiasis of non-filarial origin (podoconiosis) in the highlands of north-western Cameroon. Ann Trop Med Parasitol. 2008;102:529-40 pubmed publisher
    ..bancrofti. These findings indicate that the elephantiasis seen in the North West province of Cameroon is of non-filarial origin.
  27. Onapa A, Simonsen P, Pedersen E. Non-filarial elephantiasis in the Mt. Elgon area (Kapchorwa District) of Uganda. Acta Trop. 2001;78:171-6 pubmed
    Following reports of a high frequency of elephantiasis in Kwen County (Kapchorwa District) on the slopes of Mt. Elgon in Uganda, a baseline survey for lymphatic filariasis was carried out in three villages in the affected area...
  28. Tekola F, Ayele Z, Mariam D, Fuller C, Davey G. Development and testing of a de novo clinical staging system for podoconiosis (endemic non-filarial elephantiasis). Trop Med Int Health. 2008;13:1277-83 pubmed publisher
    ..To develop and test a robust clinical staging system for podoconiosis, a geochemical disease in individuals exposed to red clay soil...
  29. Kakati S, Doley B, Pal S, Deka U. Elephantiasis Nostras Verrucosa: a rare thyroid dermopathy in Graves' disease. J Assoc Physicians India. 2005;53:571-2 pubmed
    b>Elephantiasis Nostras Verrucosa (ENV) is a rare form of pretibial myxedema, which is nearly always associated with Graves' disease. A case is presented here of Graves' disease who had elephantiasis variety of pre-tibial myxedema (PTM).
  30. Destas K, Ashine M, Davey G. Prevalence of podoconiosis (endemic non-filarial elephantiasis) in Wolaitta, Southern Ethiopia. Trop Doct. 2003;33:217-20 pubmed
    The survey was undertaken to establish the point prevalence of overt podoconiosis (endemic non-filarial elephantiasis) in Wolaitta zone, Southern Ethiopia, and also to determine whether age- or sex-related prevalence differences exist...
  31. Molla Y, Le Blond J, Wardrop N, Baxter P, Atkinson P, Newport M, et al. Individual correlates of podoconiosis in areas of varying endemicity: a case-control study. PLoS Negl Trop Dis. 2013;7:e2554 pubmed publisher
    Podoconiosis is a non-filarial form of elephantiasis resulting in lymphedema of the lower legs. Previous studies have suggested that podoconiosis arises from the interplay of individual and environmental factors...
  32. Sathyakumar S, Suh J, Sharp V, Polsky B. Images in HIV/AIDS. Elephantiasis nostras verrucosa secondary to Kaposi sarcoma: a rare case. AIDS Read. 2008;18:81-2 pubmed
  33. Imiela A, Salle Staumont D, Breviere G, Catteau B, Martinot Duquennoy V, Piette F. Congenital elephantiasis-like lymphangiomatosis of a lower limb. Acta Derm Venereol. 2003;83:40-3 pubmed
    The case of a newborn girl with a rare, giant, congenital, tissue lymphangioma giving rise to elephantiasis of the right lower limb is presented...
  34. Karagöz E, Karaahmetoğlu G, Acar A, Turhan V, Oncul O, Gorenek L. [A case report: elephantiasis]. Turkiye Parazitol Derg. 2012;36:188-90 pubmed publisher
    ..a filarial disease which usually occurs with genital anomalies, pathologies associated with lymphedema or elephantiasis caused by a filarial infectious agent...
  35. Niang S, Diallo M, Kane A, Bocoum T, Dieng M, Ndiaye B. [Elephantiasic pretibial myxoedema: study of five cases]. Dakar Med. 2007;52:95-9 pubmed
    ..All the cases were enormous, multinodular pachydermic, bilateral, elephantiasis in the low leg and associated to Graves 'disease. The duration was 4 month to 12 year...
  36. Mwingira U, Chikawe M, Mandara W, Mableson H, Uisso C, Mremi I, et al. Lymphatic filariasis patient identification in a large urban area of Tanzania: An application of a community-led mHealth system. PLoS Negl Trop Dis. 2017;11:e0005748 pubmed publisher
    ..6 per 100,000 population), of which 4169 were reported to have hydrocoele (80.9 per 100,000), 2251 lymphoedema-elephantiasis (LE) (43.7 per 100,000) and 469 with both conditions (9.1 per 100,000)...
  37. Gómez Martín C, Murillo C, Maldonado A, Cristóbal L, Fernández Cañamaque J. Double autologous lymph node transplantation (ALNT) at the level of the knee and inguinal region for advanced lymphoedema of the lower limb (elephantiasis). J Plast Reconstr Aesthet Surg. 2014;67:267-70 pubmed publisher
    ..a chronic, progressive and debilitating condition with a difficult management, especially in advanced cases (elephantiasis)...
  38. Komorowski A, Wysocki W, Mituś J. Angiosarcoma in a chronically lymphedematous leg: an unusual presentation of Stewart-Treves syndrome. South Med J. 2003;96:807-8 pubmed
    ..We report a case of diffuse angiosarcoma of the leg in a patient with a 25-year history of idiopathic lymphedema. Despite rapid aggressive surgical treatment, the patient died 6 weeks after diagnosis. ..
  39. Molyneux D. Tropical lymphedemas--control and prevention. N Engl J Med. 2012;366:1169-71 pubmed publisher
  40. Nayak S, Acharjya B, Devi B, Pattnaik S, Patra M. Cerebriform elephantiasis of the vulva following tuberculous lymphadenitis. Indian J Dermatol Venereol Leprol. 2008;74:188 pubmed
  41. Wongkamchai S, Rochjanawatsiriroj C, Monkong N, Nochot H, Loymek S, Jiraamornnimit C, et al. Diagnostic value of IgG isotype responses against Brugia malayi antifilarial antibodies in the clinical spectrum of brugian filariasis. J Helminthol. 2006;80:363-7 pubmed
    ..exposed population comprising 74 asymptomatic amicrofilaraemics, 30 microfilaraemics, 20 lymphangitis and 16 elephantiasis patients resident in Narathiwart province, an area endemic for Brugia malayi lymphatic filariasis in southern ..
  42. Blundell G, Henderson W, Price E. Soil particles in the tissues of the foot in endemic elephantiasis of the lower legs. Ann Trop Med Parasitol. 1989;83:381-5 pubmed
    The presence of microparticles of clay is demonstrated in the dermis of the foot in a patient with endemic elephantiasis. The particles are seen to be in the phagosomes of macrophages or in the cytoplasm of other cells...
  43. Lu S, Tran T, Jones D, Meyer D, Ross J, Fisher H, et al. Localized lymphedema (elephantiasis): a case series and review of the literature. J Cutan Pathol. 2009;36:1-20 pubmed publisher
    ..A combination of lymph stasis promoting factors (trauma, obesity, infection and/or inflammatory disorders) produces localized elephantiasis.
  44. López Caballero I, Sánchez Ruvalcaba I, Sánchez Martinez L, Hernández Ordoñez O, Gómez Lara M, Flores Carrillo V. [Idiopathic scrotal elephantiasis. A case report]. Rev Med Inst Mex Seguro Soc. 2014;52:598-9 pubmed
    Penoscrotal lymphedema (scrotal elephantiasis) is a condition that has been described in areas in which filariasis is endemic. This paper presents a case of a 45-year-old man with idiopathic lymphedema isolated to the scrotum...
  45. Negussie H, Kassahun M, Fegan G, Njuguna P, Enquselassie F, McKay A, et al. Podoconiosis treatment in northern Ethiopia (GoLBet): study protocol for a randomised controlled trial. Trials. 2015;16:307 pubmed publisher
    Podoconiosis is one of the forgotten types of leg swelling (elephantiasis) in the tropics...
  46. Ahorlu C, Koka E, Adu Amankwah S, Otchere J, de Souza D. Community perspectives on persistent transmission of lymphatic filariasis in three hotspot districts in Ghana after 15 rounds of mass drug administration: a qualitative assessment. BMC Public Health. 2018;18:238 pubmed publisher
    ..They were aware that the MDA was for the treatment/control of LF (elephantiasis). It came to light that MDA compliance was affected by five related barriers...
  47. Steenbrugge F, Poffyn B, Uyttendaele D, Verdonk R, Verstraete K. Neurofibromatosis, gigantism, elephantiasis neuromatosa and recurrent massive subperiosteal hematoma: a new case report and review of 7 case reports from the literature. Acta Orthop Belg. 2001;67:168-72 pubmed
    ..In 1997, a shortening osteotomy of the left tibia was performed. However, massive gigantism with elephantiasis of the left leg remained, causing a serious functional and cosmetic problem...
  48. Davey G, Bockarie M, Wanji S, Addiss D, Fuller C, Fox L, et al. Launch of the international podoconiosis initiative. Lancet. 2012;379:1004 pubmed publisher
  49. Zhuang J, Li Y, Cai L. [Elephantiasis of bilateral lower limbs and scrotum: one case report]. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2012;24:499-500 pubmed
    This paper reports the process of diagnosis and treatment of a patient with elephantiasis of bilateral lower limbs and scrotum and the result of epidemiological investigation.
  50. Chang P, Meaux T. Onychogryphosis: A Report of Ten Cases. Skinmed. 2015;13:355-9 pubmed
    ..circulation disorders, diseases of the central nervous system, and foot abnormalities, such as hallux valgus, elephantiasis, long-standing poor personal care, hyperuricemia, and pressure from improper footwear...
  51. Leang R, Socheat D, Bin B, Bunkea T, Odermatt P. Assessment of disease and infection of lymphatic filariasis in Northeastern Cambodia. Trop Med Int Health. 2004;9:1115-20 pubmed
    ..and validating a key-informant questionnaire, consisting of four questions, with pictures of patients with leg elephantiasis and hydrocoele...
  52. Tummidi S, Patro M, Bal A, Choudhury A. Microfilariae in a bone marrow aspirate. BMC Res Notes. 2016;9:256 pubmed publisher
    ..of fever with chills and rigor, lymphadenopathy are the initial manifestations which gradually progress to elephantiasis. Wuchereria bancrofti is the most common parasite causing lymphatic filariasis in India...
  53. Yamamoto K, Matsuoka Y, Takao T, Tsujimur A, Okuyama A, Kubo T, et al. [Idiopathic elephantiasis of the penis: a case report]. Nihon Hinyokika Gakkai Zasshi. 2009;100:500-3 pubmed
    We report a case of idiopathic elephantiasis of penis. A 41-year-old man was refered to our hospital with a painful penile swelling and severe miction pain...