histiocytosis

Summary

Summary: General term for the abnormal appearance of histiocytes in the blood. Based on the pathological features of the cells involved rather than on clinical findings, the histiocytic diseases are subdivided into three groups: HISTIOCYTOSIS, LANGERHANS CELL; HISTIOCYTOSIS, NON-LANGERHANS-CELL; and HISTIOCYTIC DISORDERS, MALIGNANT.

Top Publications

  1. Takiwaki H, Adachi A, Kohno H, Ogawa Y. Intravascular or intralymphatic histiocytosis associated with rheumatoid arthritis: a report of 4 cases. J Am Acad Dermatol. 2004;50:585-90 pubmed
    ..In spite of some disagreement as to whether the dilated vessels are blood vessels or lymphatics, it is most likely that these 7 cases belong to the same clinical entity closely associated with RA. ..
  2. Catalina Fernandez I, Alvarez A, Martin F, Fernández Mera J, Sáenz Santamaria J. Cutaneous intralymphatic histiocytosis associated with rheumatoid arthritis: report of a case and review of the literature. Am J Dermatopathol. 2007;29:165-8 pubmed
    ..Recently, a specific cutaneous lesion termed "intravascular histiocytosis" has been proposed as a new entity among these dermatoses...
  3. Satter E, High W. Langerhans cell histiocytosis: a review of the current recommendations of the Histiocyte Society. Pediatr Dermatol. 2008;25:291-5 pubmed publisher
    Langerhans cell histiocytosis is a rare proliferative disorder where pathologic Langerhans cells accumulate in a variety of organs...
  4. Patel A, Cohen S, Leach I, Scharrer K. Acral histiocytic nodules: a possible new variant of non-X histiocytosis. Clin Exp Dermatol. 2012;37:245-8 pubmed publisher
    ..Clinicopathologically, this case does not seem to fit with any of the recognized subtypes, and we propose that it may represent a previously undescribed variant of the disease. ..
  5. Wollenberg A, Burgdorf W, Schaller M, Sander C. Long-lasting "christmas tree rash" in an adolescent: isotopic response of indeterminate cell histiocytosis in pityriasis rosea?. Acta Derm Venereol. 2002;82:288-91 pubmed
    ..Two diagnoses were made: a primarily clinical diagnosis of generalized eruptive histiocytosis and a more cell-biology-based diagnosis of an indeterminate cell histiocytosis...
  6. Lau S, Chu P, Weiss L. Immunohistochemical expression of Langerin in Langerhans cell histiocytosis and non-Langerhans cell histiocytic disorders. Am J Surg Pathol. 2008;32:615-9 pubmed publisher
    ..Langerin is a highly selective marker for Langerhans cells and the lesional cells of Langerhans cell histiocytosis. Although Langerin protein expression in Langerhans cell histiocytosis has been previously documented, the ..
  7. Blum R, Seymour J, Hicks R. Role of 18FDG-positron emission tomography scanning in the management of histiocytosis. Leuk Lymphoma. 2002;43:2155-7 pubmed
    ..Functional imaging with 18FDG PET provides a potential method for non-invasively detecting active disease. We report two cases where this modality was positive and facilitated therapeutic monitoring. ..
  8. Chan J, Lamant L, Algar E, Delsol G, Tsang W, Lee K, et al. ALK+ histiocytosis: a novel type of systemic histiocytic proliferative disorder of early infancy. Blood. 2008;112:2965-8 pubmed publisher
    We report 3 cases of a previously uncharacterized form of histiocytosis presenting in early infancy and showing ALK immunoreactivity. The patients presented with pallor, massive hepatosplenomegaly, anemia, and thrombocytopenia...
  9. de Alba Campomanes A, Rutar T, Crawford J, Seiff S, Goodman D, Grenert J. Crystal-storing histiocytosis and crystalline keratopathy caused by monoclonal gammopathy of undetermined significance. Cornea. 2009;28:1081-4 pubmed publisher
    ..the occurrence of crystalline keratopathy and of orbital infiltrative disease resulting from crystal-storing histiocytosis (CSH) in a patient with monoclonal gammopathy of undetermined significance...

More Information

Publications62

  1. Gizewski E, Forsting M. Histiocytosis mimicking a pineal gland tumour. Neuroradiology. 2001;43:644-6 pubmed
    We report an unusual case of isolated Langerhans cell histiocytosis of the central nervous system. A 19-year-old man presented with an incomplete ocular palsy...
  2. Dogan S, Barnes L, Cruz Vetrano W. Crystal-storing histiocytosis: report of a case, review of the literature (80 cases) and a proposed classification. Head Neck Pathol. 2012;6:111-20 pubmed publisher
    We report a case of crystal storing histiocytosis (CSH) of the upper lip and cheek in a 51-year-old woman and review the clinicopathologic features of 80 cases in the literature...
  3. Rossbach H, Dalence C, Wynn T, Tebbi C. Faisalabad histiocytosis mimics Rosai-Dorfman disease: brothers with lymphadenopathy, intrauterine fractures, short stature, and sensorineural deafness. Pediatr Blood Cancer. 2006;47:629-32 pubmed
    ..joint contractures, however, suggested a separate, rare autosomal recessive syndrome referred to as Faisalabad histiocytosis, after the family's place of origin...
  4. Itoh H, Hinoura Y, Aratake Y, Sato S, Ohno A, Miyaguni H, et al. Cytology of primary cutaneous Langerhans cell histiocytosis with a malignant phenotype. A case report. Acta Cytol. 2002;46:731-4 pubmed
    Langerhans cell histiocytosis (LCH) is a proliferative disorder of Langerhans cells, but the nature of LCH, whether reactive, benign, or malignant and neoplastic, is controversial...
  5. Hussain A, Tandon A, Prayaga A, Paul T, Narendra A. Cytomorphology and Histology Correlation of Rosai-Dorfman Disease: A 15-Year Study from a Tertiary Referral Centre in South India. Acta Cytol. 2017;61:55-61 pubmed publisher
    ..However, the disease has close differential diagnoses, including Langerhans cell histiocytosis, granulomatous lesions, and Hodgkin lymphoma...
  6. Gebrail F, Knapp M, Perotta G, Cualing H. Crystalline histiocytosis in hereditary cysinosis. Arch Pathol Lab Med. 2002;126:1135 pubmed
  7. Selway J, Harikumar P, Chu A, Langlands K. Genetic homogeneity of adult Langerhans cell histiocytosis lesions: Insights from BRAFV600E mutations in adult populations. Oncol Lett. 2017;14:4449-4454 pubmed publisher
    Langerhans cell histiocytosis (LCH) is a heterologous disease with a recognized disparity in incidence, affected sites and prognosis between adults and children...
  8. McCrea H, George E, Settler A, Schwartz T, Greenfield J. Pediatric Suprasellar Tumors. J Child Neurol. 2016;31:1367-76 pubmed publisher
    ..chiasmatic glioma, germ cell tumor, Rathke cleft and arachnoid cysts, pituitary adenoma, and histiocytosis. This review outlines both common presenting features and differentiating aspects of these lesions...
  9. Hogstad B, Berres M, Chakraborty R, Tang J, Bigenwald C, Serasinghe M, et al. RAF/MEK/extracellular signal-related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions. J Exp Med. 2018;215:319-336 pubmed publisher
    Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia characterized by granulomatous lesions containing pathological CD207+ dendritic cells (DCs) with constitutively activated mitogen-activated protein ..
  10. Vargas A, Ramírez H, Ramirez P, Foncea C, Venegas B, Astorga P. Spontaneous remission of eosinophilic granuloma of the maxilla after incisional biopsy: a case report. Head Face Med. 2016;12:21 pubmed publisher
    Langerhans cell histiocytosis (LCH), previously known as Histiocytosis X, is an infrequent disease that congregates a wide spectrum of clinical presentations with variable systemic involvement...
  11. Pettersson T, Kariniemi A, Tervonen S, Franssila K. Cytophagic histiocytic panniculitis: a report of four cases. Br J Dermatol. 1992;127:635-40 pubmed
    ..Unlike most previously described patients with CHP, three of our four patients responded to treatment with immunosuppressive or cytostatic drugs. ..
  12. Nevarez J, Mitchell M, Morgan T, Roy A, Johnson A. Association of West Nile virus with lymphohistiocytic proliferative cutaneous lesions in American alligators (Alligator mississippiensis) detected by RT-PCR. J Zoo Wildl Med. 2008;39:562-6 pubmed
    ..There was no significant difference in the WNV RT-PCR results between control animals and normal skin sections from affected animals (P = 0.24). These findings suggest that LPSA is a cutaneous manifestation of WNV in alligators. ..
  13. Eloubeidi M, Cerfolio R, Chen V, Desmond R, Syed S, Ojha B. Endoscopic ultrasound-guided fine needle aspiration of mediastinal lymph node in patients with suspected lung cancer after positron emission tomography and computed tomography scans. Ann Thorac Surg. 2005;79:263-8 pubmed
    ..It is more accurate and has a higher predictive value than either the PET scan or CT scan for posterior mediastinal lymph nodes. ..
  14. Wick M. Mediastinal pathology and the contributions of Dr. Juan Rosai. Semin Diagn Pathol. 2016;33:319-32 pubmed publisher
    ..lesions, thymolipoma, thymoliposarcoma, mediastinal solitary fibrous tumor, intrathymic langerhans-cell histiocytosis, mediastinal germ cell neoplasms, and multilocular thymic cyst...
  15. Torre O, Elia D, Caminati A, Harari S. New insights in lymphangioleiomyomatosis and pulmonary Langerhans cell histiocytosis. Eur Respir Rev. 2017;26: pubmed publisher
    Lymphangioleiomyomatosis (LAM) and pulmonary Langerhans cell histiocytosis (PLCH) are rare diseases that lead to progressive cystic destruction of the lungs...
  16. Sethi S, Fervenza F, Rajkumar S. Spectrum of manifestations of monoclonal gammopathy-associated renal lesions. Curr Opin Nephrol Hypertens. 2016;25:127-37 pubmed publisher
    ..The term monoclonal gammopathy of renal significance helps highlight patients who have renal disease secondary to monoclonal immunoglobulin secreted by a premalignant or malignant clone, but is not a disease or diagnosis in itself. ..
  17. Glasser L, Legolvan M, Horwitz H. Florid histiocytic hemophagocytosis following therapy with long acting G-CSF (pegfilgrastim). Am J Hematol. 2007;82:753-7 pubmed
    ..We recommend caution in defining indications for the use of long acting preparations of G-CSF. ..
  18. Hu M, Guan H, Lau C, Terashima K, Jin Z, Cui L, et al. An update on the clinical diagnostic value of β-hCG and αFP for intracranial germ cell tumors. Eur J Med Res. 2016;21:10 pubmed publisher
    ..1991 and 2012, and from suspected ICGCTs cases (n = 17) between 2011 and 2012 as controls [Langerhans cell histiocytosis (LCH), n = 12; and other intracranial tumor (ICT), n = 5]...
  19. Young A, Olivere J, Yoo S, Martins C, Barrett T. Two sporadic cases of adult-onset progressive mucinous histiocytosis. J Cutan Pathol. 2006;33:166-70 pubmed
    Progressive mucinous histiocytosis is a rare, benign, non-Langerhans' cell histiocytosis limited to the skin. Ten cases--all women--in four families and one sporadic case have been described in the literature...
  20. Néel A, Artifoni M, Donadieu J, Lorillon G, Hamidou M, Tazi A. [Langerhans cell histiocytosis in adults]. Rev Med Interne. 2015;36:658-67 pubmed publisher
    Langerhans cell histiocytosis (LCH) is a rare disease characterized by the infiltration of one or more organs by Langerhans cell-like dendritic cells, most often organized in granulomas...
  21. Fargeot G, Stefanizzi S, Depuydt S, Klapczynski F, Ameri A. Association between Ischemic Stroke and Erdheim-Chester Disease: A Case Report and Review of Literature. J Stroke Cerebrovasc Dis. 2017;26:e153-e155 pubmed publisher
    Erdheim-Chester disease (ECD) is a rare form of non-Langerhans cell histiocytosis characterized by a xanthogranulomatous infiltration of tissues by spumous histiocytes...
  22. Sethi S, Cuiffo B, Pinkus G, Rennke H. Crystal-storing histiocytosis involving the kidney in a low-grade B-cell lymphoproliferative disorder. Am J Kidney Dis. 2002;39:183-8 pubmed
    ..containing light chain or immunoglobulin inclusions, and the disorder has been termed crystal-storing histiocytosis. We report a case of crystal-storing histiocytosis affecting the kidney with prominent infiltration of the ..
  23. Ozkaya N, Rosenblum M, Durham B, Pichardo J, Abdel Wahab O, Hameed M, et al. The histopathology of Erdheim-Chester disease: a comprehensive review of a molecularly characterized cohort. Mod Pathol. 2017;: pubmed publisher
    Erdheim-Chester disease is a rare, non-Langerhans cell histiocytosis histologically characterized by multi-systemic proliferation of mature histiocytes in a background of inflammatory stroma...
  24. Xu X, Han S, Jiang L, Yang S, Liu X, Yuan H, et al. Clinical features and treatment outcomes of Langerhans cell histiocytosis of the spine. Spine J. 2018;18:1755-1762 pubmed publisher
    Langerhans cell histiocytosis (LCH) of the spine is a relatively rare condition with unknown etiology. The diagnosis and treatment protocols for spine LCH remain controversial...
  25. West K, Sporn T, Puri P. Multicentric reticulohistiocytosis: a unique case with pulmonary fibrosis. Arch Dermatol. 2012;148:228-32 pubmed publisher
    ..These observations document a new clinical and histopathologic presentation of MRH that is significant for expanding the idea of MRH as a systemic disease while supporting the notion that MRH is promoted by an inflammatory milieu. ..
  26. Coomer A, Liptak J. Canine histiocytic diseases. Compend Contin Educ Vet. 2008;30:202-4, 208-16; quiz 216-17 pubmed
    ..Nonneoplastic histiocytic disease (reactive histiocytosis, comprising cutaneous and systemic histiocytosis) is uncommon...
  27. Veyssier Belot C. [From granuloma to granulomatosis]. Rev Med Interne. 2004;25:848-51 pubmed
  28. de Luna M, Glikin I, Golberg J, Stringa S, Schroh R, Casas J. Benign cephalic histiocytosis: report of four cases. Pediatr Dermatol. 1989;6:198-201 pubmed
    We cared for four patients with benign cephalic histiocytosis, a self-healing non-X, nonlipid cutaneous histiocytosis of children...
  29. Li Z, Li Y, Liu W, Li J, Wang L. Mixed histiocytosis: A case report and published work review. J Dermatol. 2017;: pubmed publisher
    Histiocytoses are a group of heterogeneous diseases that encompass Langerhans cell histiocytosis and non-Langerhans cell histiocytosis...
  30. Techavichit P, Sosothikul D, Chaichana T, Teerapakpinyo C, Thorner P, Shuangshoti S. BRAF V600E mutation in pediatric intracranial and cranial juvenile xanthogranuloma. Hum Pathol. 2017;69:118-122 pubmed publisher
    Juvenile xanthogranuloma (JXG) is a cutaneous form of non-Langerhans cell histiocytosis, primarily affecting children. The lesion is presumed to originate from either macrophages or dermal dendritic cells...
  31. Fujita S, Ikeda T. The CCL2-CCR2 Axis in Lymph Node Metastasis From Oral Squamous Cell Carcinoma: An Immunohistochemical Study. J Oral Maxillofac Surg. 2017;75:742-749 pubmed publisher
    ..ligand (CCL2) to lymphatic metastasis, particularly the relation between primary OSCC and marginal sinus histiocytosis in regional lymph nodes...
  32. Haroche J, Cohen Aubart F, Charlotte F, Maksud P, Grenier P, Cluzel P, et al. The histiocytosis Erdheim-Chester disease is an inflammatory myeloid neoplasm. Expert Rev Clin Immunol. 2015;11:1033-42 pubmed publisher
    Erdheim-Chester disease (ECD) is a rare, non-Langerhans histiocytosis, characterized by the infiltration of tissues by foamy CD68(+)CD1a(-) histiocytes...
  33. Keane C, Gill D. Multi-organ involvement with crystal-storing histiocytosis. Br J Haematol. 2008;141:750 pubmed publisher
  34. Suzuki H, Asai T, Tamaki Z, Hangaishi A, Chiba S, Kurokawa M. Drug-induced hypersensitivity syndrome with rapid hematopoietic reconstitution during treatment for acute myeloid leukemia. Haematologica. 2008;93:469-70 pubmed publisher
    ..Awareness of DIHS is necessary when systemic eruptions and high fever occur in leukemic patients, especially with rapid hematopoietic recovery after chemotherapies...
  35. Duan M, Han X, Li J, Zhang W, Zhu T, Han B, et al. Comparison of vindesine and prednisone and cyclophosphamide, etoposide, vindesine, and prednisone as first-line treatment for adult Langerhans cell histiocytosis: A single-center retrospective study. Leuk Res. 2016;42:43-6 pubmed publisher
    ..regimens as first-line treatment for multisystem (MS) or multifocal single system (SS-m) adult Langerhans cell histiocytosis (LCH)...
  36. Roider E, Signer C, Fehrenbacher B, Metzler G, Schaller M, Kamarachev J, et al. Individualized Treatment Approaches for Langerhans Cell Histiocytosis. Br J Dermatol. 2017;: pubmed publisher
    Langerhans cell histiocytosis (LCH) belongs to the rare histiocytic disorders, and has an estimated incidence of 1-2 cases per million adults [1]...
  37. Kumar B, Walsh R, Walter N, Little J. Histiocytic necrotizing lymphadenitis (Kikuchi's disease) of the cervical lymph nodes. ORL J Otorhinolaryngol Relat Spec. 1997;59:176-8 pubmed
    ..It may be mistaken for malignant lymphoma, both clinically and histologically. Though well recognized in the pathological literature few clinicians are aware of the disease. We present a case of cervical HNL and review the literature. ..
  38. Berres M, Allen C, Merad M. Pathological consequence of misguided dendritic cell differentiation in histiocytic diseases. Adv Immunol. 2013;120:127-61 pubmed publisher
    ..Langerhans cell histiocytosis is the most frequent of histiocytosis in humans and has been thought to arise from the abnormal accumulation ..
  39. Murray D, Marshall M, England E, Mander J, Chakera T. Erdheim-chester disease. Clin Radiol. 2001;56:481-4 pubmed
    ..A brief review of the literature regarding the manifestations of ECD is included. In cases of non-malignant retroperitoneal infiltration, ECD should be considered as a diagnosis and radiographs of the long bones performed. ..
  40. Schlienger J, Delemer B, Vinzio S. [Impact of systemic disease on the pituitary gland]. Ann Endocrinol (Paris). 2006;67:316-24 pubmed
    ..to review recent clinical data about diagnosis of these rare diseases, with a focus on granulomatous diseases: histiocytosis and sarcoidosis...
  41. Andersen J, Mortensen J, Bech B, Højgaard L, Borgwardt L. First experiences from Copenhagen with paediatric single photon emission computed tomography/computed tomography. Nucl Med Commun. 2011;32:356-62 pubmed publisher
    ..scintigraphies (neuroblastoma), three In-octreotide scintigraphies (two carcinoid tumours, one Langerhans cell histiocytosis) and one Tc-dimercaptosuccinic acid scintigraphy (suspected renal transplant infarction)...
  42. Mosheimer B, Oppl B, Zandieh S, Fillitz M, Keil F, Klaushofer K, et al. Bone Involvement in Rosai-Dorfman Disease (RDD): a Case Report and Systematic Literature Review. Curr Rheumatol Rep. 2017;19:29 pubmed publisher
    ..RDD is a nonmalignant, classically sporadic histiocytosis. Nevertheless, increasing evidence also suggests familial forms of the disease...
  43. Mínguez I, Mínguez J, Bonet J, Penarrocha M, Sanchis J. Oral manifestations of chronic disseminated histiocytosis. A report of 10 cases. Med Oral. 2004;9:152-54, 149-52 pubmed
    Chronic disseminated histiocytosis is a systemic disorder resulting from tumor proliferation of Langerhans-type histiocytic cells...
  44. Belajouza Noueiri C, Denguezli M, Selmi H, Mokni M, Jomaa B, Nouira R. [Intense hemosiderin deposits in a case of self-healing congenital histiocytosis]. Ann Dermatol Venereol. 2001;128:238-40 pubmed
    Congenital self healing histiocytosis, described for the first time in 1973 by Hashimoto and Pritzker, is characterized by multiple violaceous brown cutaneous papulonodules present at birth and disappearing spontaneously in 2 to 4 months...
  45. Rodriguez F, Gamez J, Vrana J, Theis J, Giannini C, Scheithauer B, et al. Immunoglobulin derived depositions in the nervous system: novel mass spectrometry application for protein characterization in formalin-fixed tissues. Lab Invest. 2008;88:1024-37 pubmed publisher
    ..case wherein kappa-light chain was found by LC-MS/MS only; the pathology was consistent with crystal-storing histiocytosis. In the second case, the crystals contained immunoglobulin G within CD138+ plasma cells...
  46. Rothschild B. Differential diagnostic perspectives provided by en face microscopic examination of articular surface defects. Clin Rheumatol. 2018;37:831-836 pubmed publisher
    ..disease (CPPD), gout, metastatic cancer, multiple myeloma, septic arthritis, tuberculosis, fungal arthritis, histiocytosis and sickle cell anemia (Rothschild and Rothschild Clin Infect Dis 20(5):1402-1408, 1995; Rothschild et al...
  47. De Risio L, Brown R, Tennant B, Sparkes A, Matiasek L, De Stefani A, et al. Slowly progressive lymphohistiocytic meningoencephalomyelitis in 21 adult cats presenting with peculiar neurological signs. J Feline Med Surg. 2012;14:250-6 pubmed publisher
  48. Meyle J, Gonzales J. Influences of systemic diseases on periodontitis in children and adolescents. Periodontol 2000. 2001;26:92-112 pubmed
    ..Since the genetic basis of many of the diseases has been identified, future developments permit the correction of at least some of these defects by gene therapy. ..
  49. Thiel A, Braun W, Cary M, Engelhardt J, Goodman D, Hall W, et al. Calcium lignosulphonate: re-evaluation of relevant endpoints to re-confirm validity and NOAEL of a 90-day feeding study in rats. Regul Toxicol Pharmacol. 2013;66:286-99 pubmed publisher
    ..The EFSA Panel further disagreed with the conclusion that the treatment-related observation of foamy histiocytosis in mesenteric lymph nodes was non-adverse and asked whether this observation would progress to something more ..
  50. Zioni F, Giovanardi P, Bozzoli M, Artusi T, Bonacorsi G, Sighinolfi P. Massive bone marrow crystal-storing histiocytosis in a patient with IgA-lambda multiple myeloma and extensive extramedullary disease. A case report. Tumori. 2004;90:348-51 pubmed
    ..In our patient this plasma cell neoplasm was associated with a rare condition named crystal-storing histiocytosis (CSH), resulting from the storage in reactive histiocytes of crystalline immunoglobulin inclusions...
  51. Stokes M, Aronoff B, Siegel D, D Agati V. Dysproteinemia-related nephropathy associated with crystal-storing histiocytosis. Kidney Int. 2006;70:597-602 pubmed
  52. Monsereenusorn C, Rodriguez Galindo C. Clinical Characteristics and Treatment of Langerhans Cell Histiocytosis. Hematol Oncol Clin North Am. 2015;29:853-73 pubmed publisher
    Langerhans cell histiocytosis (LCH) is a disease caused by clonal proliferation of CD1a+/CD207+ cells that is characterized by a spectrum of varying degrees of organ involvement and dysfunction...
  53. Chen C, Chen C, Chen H, Liao H, Lin H. Multicentric reticulohistiocytosis presenting with destructive polyarthritis, laryngopharyngeal dysfunction, and a huge reticulohistiocytoma. J Clin Rheumatol. 2006;12:252-4 pubmed
    ..This polyarthritis, which can be confused with rheumatoid arthritis, can be diagnosed by careful immunohistochemical examination of biopsies. To prevent the irreversible disease process, early and aggressive therapy is necessary. ..