immunological synapses


Summary: The interfaces between T-CELLS and ANTIGEN-PRESENTING CELLS. Supramolecular organization of proteins takes place at these synapses involving various types of immune cells. Immunological synapses can have several functions including LYMPHOCYTE ACTIVATION; enhancing, balancing, or terminating signaling; or directing cytokine secretion.

Top Publications

  1. Clarke F, Jordan C, Gutiérrez Martínez E, Bibby J, Sanchez Blanco C, Cornish G, et al. Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells. PLoS ONE. 2017;12:e0186625 pubmed publisher
  2. Garber K. Beyond ipilimumab: new approaches target the immunological synapse. J Natl Cancer Inst. 2011;103:1079-82 pubmed publisher
  3. Netter P, Anft M, Watzl C. Termination of the Activating NK Cell Immunological Synapse Is an Active and Regulated Process. J Immunol. 2017;199:2528-2535 pubmed publisher
    ..We propose that the maintenance of an existing IS is a dynamic and regulated process to allow for effective serial killing of NK cells. ..
  4. Borger J, Morrison V, Filby A, Garcia C, Uotila L, Simbari F, et al. Caveolin-1 Influences LFA-1 Redistribution upon TCR Stimulation in CD8 T Cells. J Immunol. 2017;199:874-884 pubmed publisher
    ..Our results identify a role for Cav1 in membrane organization and β2 integrin function in primary CD8 T cells. ..
  5. Huse M. The T-cell-receptor signaling network. J Cell Sci. 2009;122:1269-73 pubmed publisher
  6. Bouchet J, Del Río Iñiguez I, Vázquez Chávez E, Lasserre R, Agüera González S, Cuche C, et al. Rab11-FIP3 Regulation of Lck Endosomal Traffic Controls TCR Signal Transduction. J Immunol. 2017;198:2967-2978 pubmed publisher
    ..Therefore, our data underscore the importance of finely regulated endosomal traffic in TCR signal transduction and T cell activation leading to IL-2 production. ..
  7. Li J, Stagg N, Johnston J, Harris M, Menzies S, DiCara D, et al. Membrane-Proximal Epitope Facilitates Efficient T Cell Synapse Formation by Anti-FcRH5/CD3 and Is a Requirement for Myeloma Cell Killing. Cancer Cell. 2017;31:383-395 pubmed publisher
    ..These data demonstrate the potential for the anti-FcRH5/CD3 TDB, alone or in combination with inhibition of PD-1/PD-L1 signaling, in the treatment of MM and other B cell malignancies. ..
  8. Gardell J, Parker D. Despite disorganized synapse structure, Th2 cells maintain directional delivery of CD40L to antigen-presenting B cells. PLoS ONE. 2017;12:e0186573 pubmed publisher
  9. Klein Hessling S, Muhammad K, Klein M, Pusch T, Rudolf R, Flöter J, et al. NFATc1 controls the cytotoxicity of CD8+ T cells. Nat Commun. 2017;8:511 pubmed publisher
    ..T lymphocytes showed a defective cytoskeleton organization and recruitment of cytosolic organelles to immunological synapses. These cells have reduced cytotoxicity against tumor cells, and mice with NFATc1-deficient T cells are ..

More Information


  1. Ashdown G, Burn G, Williamson D, Pandžić E, Peters R, Holden M, et al. Live-Cell Super-resolution Reveals F-Actin and Plasma Membrane Dynamics at the T Cell Synapse. Biophys J. 2017;112:1703-1713 pubmed publisher
    ..We hypothesize that this apparent cytoskeletal-membrane coupling could provide a mechanism for driving the observed retrograde flow of signaling molecules such as the TCR, Lck, ZAP70, LAT, and SLP76. ..
  2. Bustos Morán E, Blas Rus N, Martin Cófreces N, Sánchez Madrid F. Microtubule-associated protein-4 controls nanovesicle dynamics and T cell activation. J Cell Sci. 2017;130:1217-1223 pubmed publisher
    ..Our data indicate that MAP4 acts as a checkpoint molecule that balances positive and negative hallmarks of T cell activation. ..
  3. Wang J, Lee J, Christian S, Dang Lawson M, Pritchard C, Freeman S, et al. The Rap1-cofilin-1 pathway coordinates actin reorganization and MTOC polarization at the B cell immune synapse. J Cell Sci. 2017;130:1094-1109 pubmed publisher
    ..Thus the Rap1-cofilin-1 pathway coordinates actin and microtubule organization at the immune synapse. ..
  4. Grakoui A, Bromley S, Sumen C, Davis M, Shaw A, Allen P, et al. Pillars article: The immunological synapse: a molecular machine controlling T cell activation. Science. 1999. 285: 221-227. J Immunol. 2015;194:4066-72 pubmed
  5. Ghai R, Tello Lafoz M, Norwood S, Yang Z, Clairfeuille T, Teasdale R, et al. Phosphoinositide binding by the SNX27 FERM domain regulates its localization at the immune synapse of activated T-cells. J Cell Sci. 2015;128:553-65 pubmed
  6. García Ortiz A, Martín Cófreces N, Ibiza S, Ortega A, Izquierdo Alvarez A, Trullo A, et al. eNOS S-nitrosylates β-actin on Cys374 and regulates PKC-θ at the immune synapse by impairing actin binding to profilin-1. PLoS Biol. 2017;15:e2000653 pubmed publisher
    ..These findings unveil a novel NO-dependent mechanism by which the actin cytoskeleton controls the organization and activation of signaling microclusters at the IS. ..
  7. Galgano D, Onnis A, Pappalardo E, Galvagni F, Acuto O, Baldari C. The T cell IFT20 interactome reveals new players in immune synapse assembly. J Cell Sci. 2017;130:1110-1121 pubmed publisher
    ..Our data underscore the traffic-related role of an IFT20 complex that includes components of the intracellular trafficking machinery in IS assembly. ..
  8. Schoppmeyer R, Zhao R, Cheng H, Hamed M, Liu C, Zhou X, et al. Human profilin 1 is a negative regulator of CTL mediated cell-killing and migration. Eur J Immunol. 2017;47:1562-1572 pubmed publisher
    ..Taken together, we conclude that PFN1 is a negative regulator for CTL-mediated cytotoxicity and may have an impact on CTL functionality in a tumor-related context. ..
  9. Papa I, Saliba D, Ponzoni M, Bustamante S, Canete P, Gonzalez Figueroa P, et al. TFH-derived dopamine accelerates productive synapses in germinal centres. Nature. 2017;547:318-323 pubmed publisher
    ..Delivery of neurotransmitters across the T-B-cell synapse may be advantageous in the face of infection. ..
  10. Yewdell J, Dolan B. Immunology: Cross-dressers turn on T cells. Nature. 2011;471:581-2 pubmed publisher
  11. Stinchcombe J, Griffiths G. Communication, the centrosome and the immunological synapse. Philos Trans R Soc Lond B Biol Sci. 2014;369: pubmed publisher
    ..The features observed at the immunological synapse show parallels to centrosome (basal body) polarization seen in cilia and flagella, and the cellular communication that is now known to occur at all of these sites. ..