hematopoietic system

Summary

Summary: The blood-making organs and tissues, principally the bone marrow and lymph nodes.

Top Publications

  1. Medvinsky A, Rybtsov S, Taoudi S. Embryonic origin of the adult hematopoietic system: advances and questions. Development. 2011;138:1017-31 pubmed publisher
    Definitive hematopoietic stem cells (HSCs) lie at the foundation of the adult hematopoietic system and provide an organism throughout its life with all blood cell types...
  2. Wey S, Luo B, Tseng C, Ni M, Zhou H, Fu Y, et al. Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling. Blood. 2012;119:817-25 pubmed publisher
    ..GRP78 in leukemogenesis, we created a biallelic conditional knockout mouse model of GRP78 and PTEN in the hematopoietic system. Strikingly, heterozygous knockdown of GRP78 in PTEN null mice is sufficient to restore the hematopoietic ..
  3. Toscano M, Frecha C, Benabdellah K, Cobo M, Blundell M, Thrasher A, et al. Hematopoietic-specific lentiviral vectors circumvent cellular toxicity due to ectopic expression of Wiskott-Aldrich syndrome protein. Hum Gene Ther. 2008;19:179-97 pubmed publisher
    ..We therefore postulate that transcriptionally regulated lentiviral vectors represent a safer and efficient alternative for the development of clinical protocols of WAS gene therapy...
  4. Wang B, Tanaka K, Ninomiya Y, Maruyama K, Vares G, Eguchi Kasai K, et al. Relieved residual damage in the hematopoietic system of mice rescued by radiation-induced adaptive response (Yonezawa Effect). J Radiat Res. 2013;54:45-51 pubmed publisher
    ..In this study, we verified the existence of AR and further investigated residual damage in the hematopoietic system in surviving animals...
  5. Tothova Z, Gilliland D. FoxO transcription factors and stem cell homeostasis: insights from the hematopoietic system. Cell Stem Cell. 2007;1:140-52 pubmed publisher
  6. Beerman I, Maloney W, Weissmann I, Rossi D. Stem cells and the aging hematopoietic system. Curr Opin Immunol. 2010;22:500-6 pubmed publisher
    Advancing age is accompanied by a number of clinically significant conditions arising in the hematopoietic system that include: diminution and decreased competence of the adaptive immune system, elevated incidence of certain autoimmune ..
  7. Wilson N, Timms R, Kinston S, Cheng Y, Oram S, Landry J, et al. Gfi1 expression is controlled by five distinct regulatory regions spread over 100 kilobases, with Scl/Tal1, Gata2, PU.1, Erg, Meis1, and Runx1 acting as upstream regulators in early hematopoietic cells. Mol Cell Biol. 2010;30:3853-63 pubmed publisher
    The growth factor independence 1 (Gfi1) gene was originally discovered in the hematopoietic system, where it functions as a key regulator of stem cell homeostasis, as well as neutrophil and T-cell development...
  8. Deutsch D, Haze Filderman A, Blumenfeld A, Dafni L, Leiser Y, Shay B, et al. Amelogenin, a major structural protein in mineralizing enamel, is also expressed in soft tissues: brain and cells of the hematopoietic system. Eur J Oral Sci. 2006;114 Suppl 1:183-9; discussion 201-2, 381 pubmed
    ..study describes our recent discovery of amelogenin expression in soft tissues: in brain and in cells of the hematopoietic system, such as macrophages, megakaryocytes and in some of the hematopoietic stem cells...
  9. Abe M, Sato Y. Puromycin insensitive leucyl-specific aminopeptidase (PILSAP) is required for the development of vascular as well as hematopoietic system in embryoid bodies. Genes Cells. 2006;11:719-29 pubmed

More Information

Publications76

  1. Akushevich I, Veremeyeva G, Dimov G, Ukraintseva S, Arbeev K, Akleyev A, et al. Modeling deterministic effects in hematopoietic system caused by chronic exposure to ionizing radiation in large human cohorts. Health Phys. 2010;99:322-9 pubmed publisher
    A new model of the hematopoietic system for humans chronically exposed to ionizing radiation allows for quantitative description of the initial hematopoiesis inhibition and subsequent increase in the risks of late stochastic effects such ..
  2. Larsson E, Ljungberg M, Mårtensson L, Nilsson R, Tennvall J, Strand S, et al. Use of Monte Carlo simulations with a realistic rat phantom for examining the correlation between hematopoietic system response and red marrow absorbed dose in Brown Norway rats undergoing radionuclide therapy with (177)Lu- and (90)Y-BR96 mAbs. Med Phys. 2012;39:4434-43 pubmed publisher
    ..The aim of this study was to develop an anatomically realistic dosimetry model for Brown Norway rats to calculate S factors for use in evaluating correlations between absorbed dose and biological effects in a preclinical therapy study...
  3. Janz S. Uncovering MYC's full oncogenic potential in the hematopoietic system. Oncogene. 2005;24:3541-3 pubmed
    ..Suzanne Cory and her associates took advantage of the Vav promoter to express MYC throughout the hematopoietic system in transgenic mice...
  4. Xu W, Shen X, Yang F, Han Y, Li R, Xue D, et al. Protective effect of polysaccharides isolated from Tremella fuciformis against radiation-induced damage in mice. J Radiat Res. 2012;53:353-60 pubmed
    ..in bone marrow (BMNC) and spleen index were used to investigate the radioprotective effect of WTF-B on the hematopoietic system. The treatment groups receiving WTF-B at 18, 54 and 72 mg/kg b.w...
  5. Gounaris E, Erdman S, Restaino C, Gurish M, Friend D, Gounari F, et al. Mast cells are an essential hematopoietic component for polyp development. Proc Natl Acad Sci U S A. 2007;104:19977-82 pubmed
    ..Our data suggest that MC are an essential hematopoietic component for preneoplastic polyp development and are a novel target for therapeutic intervention...
  6. Oberdoerffer P, Kanellopoulou C, Heissmeyer V, Paeper C, Borowski C, Aifantis I, et al. Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages. Mol Cell Biol. 2005;25:3896-905 pubmed
    ..The extent of gene inactivation varies between different cell types and is least efficient in mature lymphocytes. Our data suggest that RNAi is affected by factors beyond small interfering RNA-mRNA stoichiometry...
  7. Mortensen M, Watson A, Simon A. Lack of autophagy in the hematopoietic system leads to loss of hematopoietic stem cell function and dysregulated myeloid proliferation. Autophagy. 2011;7:1069-70 pubmed
    ..By conditionally deleting the essential autophagy gene Atg7 in the hematopoietic system, we found that autophagy is required for the maintenance of true HSCs and therefore also of downstream ..
  8. Yoshimoto M, Montecino Rodriguez E, Ferkowicz M, Porayette P, Shelley W, Conway S, et al. Embryonic day 9 yolk sac and intra-embryonic hemogenic endothelium independently generate a B-1 and marginal zone progenitor lacking B-2 potential. Proc Natl Acad Sci U S A. 2011;108:1468-73 pubmed publisher
    ..The results of these studies expand our knowledge of hemogenic endothelial sites specifying distinct B-1 and MZ cell fates apart from B-2 cells and independent of an HSC origin during development...
  9. Monticelli S, Ansel K, Xiao C, Socci N, Krichevsky A, Thai T, et al. MicroRNA profiling of the murine hematopoietic system. Genome Biol. 2005;6:R71 pubmed
    ..It is becoming clear that miRNAs play an important role in the regulation of gene expression during development. However, in mammals, expression data are principally based on whole tissue analysis and are still very incomplete...
  10. Kataoka H, Hayashi M, Nakagawa R, Tanaka Y, Izumi N, Nishikawa S, et al. Etv2/ER71 induces vascular mesoderm from Flk1+PDGFR?+ primitive mesoderm. Blood. 2011;118:6975-86 pubmed publisher
    ..We propose that Flk-1(+)/PDGFR?(+) primitive mesoderm is committed into Flk-1(+)/PDGFR?(-) vascular mesoderm through Etv2 and that up-regulation of Etv2 by VEGF promotes this commitment...
  11. Gazit R, Weissman I, Rossi D. Hematopoietic stem cells and the aging hematopoietic system. Semin Hematol. 2008;45:218-24 pubmed publisher
    The etiology of the age-associated pathophysiological changes of the hematopoietic system including the onset of anemia, diminished adaptive immune competence, and myelogenous disease development are underwritten by the loss of normal ..
  12. Huang H, Zon L. Regulation of stem cells in the zebra fish hematopoietic system. Cold Spring Harb Symp Quant Biol. 2008;73:111-8 pubmed publisher
    ..on the contributions of the zebra fish model to our understanding of stem cell regulation within the hematopoietic system. Studies in zebra fish have been valuable for identifying new genetic and signaling factors that affect HSC ..
  13. Ottersbach K, Smith A, Wood A, Gottgens B. Ontogeny of haematopoiesis: recent advances and open questions. Br J Haematol. 2010;148:343-55 pubmed publisher
    ..In light of these rapid recent advances, research into the embryonic origins of the haematopoietic system should remain one of the most vibrant disciplines within the wider field of haematology for the foreseeable future...
  14. Cao Y, Xu Q, Jin Z, Zhang J, Lu M, Nie J, et al. Effects of 900-MHz microwave radiation on gamma-ray-induced damage to mouse hematopoietic system. J Toxicol Environ Health A. 2010;73:507-13 pubmed publisher
    ..Consequently, studies were undertaken to examine the effects of microwave exposure on hematopoietic system adversely altered by gamma-ray irradiation in mice...
  15. Montanez E, Piwko Czuchra A, Bauer M, Li S, Yurchenco P, Fassler R. Analysis of integrin functions in peri-implantation embryos, hematopoietic system, and skin. Methods Enzymol. 2007;426:239-89 pubmed
    ..that are routinely used in our laboratory to investigate embryos, organs, and cells (peri-implantation embryos, hematopoietic system, epidermis, and hair follicles) that lack the expression of integrins or integrin-associated proteins.
  16. Fujiwara T, O Geen H, Keles S, Blahnik K, Linnemann A, Kang Y, et al. Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell. 2009;36:667-81 pubmed publisher
    ..These results establish fundamental principles underlying GATA factor mechanisms in chromatin and illustrate a complex network of considerable importance for the control of hematopoiesis...
  17. Raaijmakers M. Niche contributions to oncogenesis: emerging concepts and implications for the hematopoietic system. Haematologica. 2011;96:1041-8 pubmed publisher
    ..Based on this, conceptual views and therapeutic implications will be provided on the emerging role of the bone marrow microenvironment in leukemogenesis...
  18. Ward J, Rehg J, Morse H. Differentiation of rodent immune and hematopoietic system reactive lesions from neoplasias. Toxicol Pathol. 2012;40:425-34 pubmed publisher
    ..Proliferative lesions may be difficult to differentiate from lymphomas and leukemias. The use of immunohistochemistry, compartmental pathology, and methods for the evaluation of clonality will make interpretation easier. ..
  19. Li Y, Cao W, Guo J, Miao S, Ding G, Li K, et al. Comparative investigations on the protective effects of rhodioside, ciwujianoside-B and astragaloside IV on radiation injuries of the hematopoietic system in mice. Phytother Res. 2011;25:644-53 pubmed publisher
    ..the protective effects of three glycosides (rhodioside, ciwujianoside-B and astragaloside IV) on the hematopoietic system in the mice exposed to ?-rays, and to examine the possible mechanisms involved...
  20. Takiguchi M, Dow L, Prier J, Carmichael C, Kile B, Turner S, et al. Variability of inducible expression across the hematopoietic system of tetracycline transactivator transgenic mice. PLoS ONE. 2013;8:e54009 pubmed publisher
  21. Vadillo E, Pelayo R. [Toll-like receptors in development and function of the hematopoietic system]. Rev Invest Clin. 2012;64:461-76 pubmed
    ..Of special interest is the research progress in the TLR functional expression by primitive hematopoietic stem and progenitor cells...
  22. Swiers G, de Bruijn M, Speck N. Hematopoietic stem cell emergence in the conceptus and the role of Runx1. Int J Dev Biol. 2010;54:1151-63 pubmed publisher
    ..irradiated or otherwise immunocompromised adult organisms provide long-term reconstitution of the entire hematopoietic system. They emerge in the vertebrate conceptus around midgestation...
  23. Burdelya L, Krivokrysenko V, Tallant T, Strom E, Gleiberman A, Gupta D, et al. An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models. Science. 2008;320:226-30 pubmed publisher
    ..CBLB502 also showed radioprotective activity in lethally irradiated rhesus monkeys. Thus, TLR5 agonists could potentially improve the therapeutic index of cancer radiotherapy and serve as biological protectants in radiation emergencies...
  24. Wang B, Tanaka K, Morita A, Ninomiya Y, Maruyama K, Fujita K, et al. Sodium orthovanadate (vanadate), a potent mitigator of radiation-induced damage to the hematopoietic system in mice. J Radiat Res. 2013;54:620-9 pubmed publisher
  25. Bigas A, Robert Moreno A, Espinosa L. The Notch pathway in the developing hematopoietic system. Int J Dev Biol. 2010;54:1175-88 pubmed publisher
    ..Here, we will review the work from recent years showing how Notch participates in the embryonic development of hematopoiesis in the mouse, but also in other organisms such as chick, zebrafish and flies...
  26. Serobyan N, Jagannathan S, Orlovskaya I, Schraufstatter I, Skok M, Loring J, et al. The cholinergic system is involved in regulation of the development of the hematopoietic system. Life Sci. 2007;80:2352-60 pubmed
    ..Our data provide evidence that the nicotine-induced imbalance of the cholinergic system during gestation interferes with normal development and provides the basis for negative health outcomes postpartum in active and passive smokers...
  27. Penack O, Smith O, Cunningham Bussel A, Liu X, Rao U, Yim N, et al. NOD2 regulates hematopoietic cell function during graft-versus-host disease. J Exp Med. 2009;206:2101-10 pubmed publisher
    ..We conclude that NOD2 regulates the development of GVHD through its inhibitory effect on host APC function...
  28. Martinel Lamas D, Carabajal E, Prestifilippo J, Rossi L, Elverdin J, Merani S, et al. Protection of radiation-induced damage to the hematopoietic system, small intestine and salivary glands in rats by JNJ7777120 compound, a histamine H4 ligand. PLoS ONE. 2013;8:e69106 pubmed publisher
    ..JNJ7777120 exhibits radioprotective effects against radiation-induced cytotoxic and genotoxic damages in small intestine, SMG and hematopoietic tissues and, thus, could be of clinical value for patients undergoing radiotherapy. ..
  29. Gattermann N. Mitochondrial DNA mutations in the hematopoietic system. Leukemia. 2004;18:18-22 pubmed
  30. Schweitzer K, Drager A, van der Valk P, Thijsen S, Zevenbergen A, Theijsmeijer A, et al. Constitutive expression of E-selectin and vascular cell adhesion molecule-1 on endothelial cells of hematopoietic tissues. Am J Pathol. 1996;148:165-75 pubmed
    ..These results suggest that E-selectin plays a role in the homing of HPCs and that its constitutive expression on endothelial cells of hematopoietic organs may be essential in the initial step of the homing process...
  31. Pereira D, Gomes L, el Cheikh M, Borojevic R. Dipeptidyl peptidase IV (CD26) activity in the hematopoietic system: differences between the membrane-anchored and the released enzyme activity. Braz J Med Biol Res. 2003;36:567-78 pubmed
    ..This is compatible with membrane-associated events and direct cell-cell interactions, whilst the long-range activity depending upon soluble enzyme is less probable in view of the low affinity of this form...
  32. Liang H, Chen Q, Coles A, Anderson S, Pihan G, Bradley A, et al. Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue. Cancer Cell. 2003;4:349-60 pubmed
    ..Furthermore, analysis of human primary leukemias reveals deletion of the WNT5A gene and/or loss of WNT5A expression in a majority of the patient samples. These results demonstrate that Wnt5a suppresses hematopoietic malignancies...
  33. Milsom M, Fairbairn L. Protection and selection for gene therapy in the hematopoietic system. J Gene Med. 2004;6:133-46 pubmed
    ..Here we review potential means of conferring a selective advantage to hematopoietic stem cells and their progeny, and discuss the issues that surround the use of selective advantages in vivo...
  34. Cheng J, Baumhueter S, Cacalano G, Carver Moore K, Thibodeaux H, Thomas R, et al. Hematopoietic defects in mice lacking the sialomucin CD34. Blood. 1996;87:479-90 pubmed
    ..However, the hematopoietic sites of adult CD34-deficient mice may still have a significant reservoir of progenitor cells that allows for normal recovery after nonmyeloablative peripheral cell depletion...
  35. Maestroni G, Conti A. Melatonin and the immune-hematopoietic system therapeutic and adverse pharmacological correlates. Neuroimmunomodulation. 1996;3:325-32 pubmed
    ..In conclusion, melatonin seems to be an important immunomodulatory hormone which deserves to be further studied to identify its relevance in immune-based diseases, its therapeutic indications and its adverse effects...
  36. Keller G, Lacaud G, Robertson S. Development of the hematopoietic system in the mouse. Exp Hematol. 1999;27:777-87 pubmed
  37. Nose M, Wang B, Itsukaichi H, Yukawa O, Hayata I, Yamada T, et al. Rescue of lethally irradiated mice from hematopoietic death by pre-exposure to 0.5 Gy X rays without recovery from peripheral blood cell depletion and its modification by OK432. Radiat Res. 2001;156:195-204 pubmed
    ..These results suggest that radioresistance induced by pre-exposure to 0.5 Gy X rays is not stable, but rather varies with the physiological conditions, and can be modulated by factors such as OK432...
  38. Wolber F, Leonard E, Michael S, Orschell Traycoff C, Yoder M, Srour E. Roles of spleen and liver in development of the murine hematopoietic system. Exp Hematol. 2002;30:1010-9 pubmed
    ..To investigate these issues we quantitated CFC and HSC activity in the spleen, BM, peripheral blood, and liver of the mouse during ontogeny...
  39. Stone H, Moulder J, Coleman C, Ang K, Anscher M, Barcellos Hoff M, et al. Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003. Radiat Res. 2004;162:711-28 pubmed
  40. Zhao C, Blum J, Chen A, Kwon H, Jung S, Cook J, et al. Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell. 2007;12:528-41 pubmed
    ..To test if Wnt signaling can regulate the self-renewal of both stem cells and cancer cells in the hematopoietic system, we developed mice that lack beta-catenin in their hematopoietic cells...
  41. Bhatacharya P, Pandey G, Mukherjee K. Production and purification of recombinant human granulocyte-macrophage colony stimulating factor (GM-CSF) from high cell density cultures of Pichia pastoris. Bioprocess Biosyst Eng. 2007;30:305-12 pubmed
    ..The protein migrated as a diffuse band on SDS-PAGE at the range of 28-35 kDa indicating differential glycosylation. The secreted protein was purified to 95% in two steps using cation exchange and size exclusion chromatography. ..
  42. Tian F, Liu A. [AGM region and hematopoiesis during ontogeny--review]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2005;13:164-8 pubmed
    ..This review describes the origin and precise location of HSC in the embryo and in AGM region, the hematopoietic microenvironment and the hematopoietic regulatory mechanisms in AGM region. ..
  43. Yuasa H, Oike Y, Iwama A, Nishikata I, Sugiyama D, Perkins A, et al. Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression. EMBO J. 2005;24:1976-87 pubmed
    ..Our results reveal that GATA-2 is presumably one of critical targets for Evi1 and that transcription factors regulate the HSC pool hierarchically. ..
  44. Sandeep D, Nair C. Radioprotection by ?-asarone: prevention of genotoxicity and hematopoietic injury in mammalian organism. Mutat Res. 2011;722:62-8 pubmed publisher
    ..These studies highlight the role of ?-asarone as a good natural radioprotecting agent with therapeutic implications in case of radiation-exposure scenarios. ..
  45. Lu X, Wei Y, Liu F. Direct regulation of p53 by miR-142a-3p mediates the survival of hematopoietic stem and progenitor cells in zebrafish. Cell Discov. 2015;1:15027 pubmed publisher
    ..to self-renew and differentiate into all blood cell lineages, and thus sustain life-long homeostasis of the hematopoietic system. Although intensive studies have focused on the orchestrated genetic network of hematopoietic stem and ..
  46. De Luca A, Bozza S, Zelante T, Zagarella S, D Angelo C, Perruccio K, et al. Non-hematopoietic cells contribute to protective tolerance to Aspergillus fumigatus via a TRIF pathway converging on IDO. Cell Mol Immunol. 2010;7:459-70 pubmed publisher
    ..Thus, distinct immune pathways contribute to resistance and tolerance to the fungus, to which the hematopoietic/non-hematopoietic compartments contribute through distinct, yet complementary, roles. ..
  47. Zazpe Oyarzun C. [Review of knowledge on the hematoimmunological system]. Enferm Intensiva. 2005;16:35-9 pubmed
  48. Levesque J, Winkler I. Hierarchy of immature hematopoietic cells related to blood flow and niche. Curr Opin Hematol. 2011;18:220-5 pubmed publisher
    ..More sophisticated three-dimensional fluorescence microscopy techniques on whole mount bone fragments should provide new insights in the spatial organization of niches relative to bone and microcirculation in the bone marrow. ..
  49. Berrun A, Stachura D. Development of an In Vitro Assay to Quantitate Hematopoietic Stem and Progenitor Cells (HSPCs) in Developing Zebrafish Embryos. J Vis Exp. 2017;: pubmed publisher
    ..capabilities have been developed, utilizing transplantation and subsequent reconstitution of the hematopoietic system in addition to visualizing specialized transgenic lines with confocal microscopy...
  50. Weigert A, Weichand B, Sekar D, Sha W, Hahn C, Mora J, et al. HIF-1? is a negative regulator of plasmacytoid DC development in vitro and in vivo. Blood. 2012;120:3001-6 pubmed publisher
    ..Our data indicate that the low oxygen content in the bone marrow might limit pDC development. This might be an environmental mechanism to restrict the numbers of these potentially autoreactive cells. ..
  51. Wozniak R, Boyer M, Grass J, Lee Y, Bresnick E. Context-dependent GATA factor function: combinatorial requirements for transcriptional control in hematopoietic and endothelial cells. J Biol Chem. 2007;282:14665-74 pubmed
  52. Taylor E, Taoudi S, Medvinsky A. Hematopoietic stem cell activity in the aorta-gonad-mesonephros region enhances after mid-day 11 of mouse development. Int J Dev Biol. 2010;54:1055-60 pubmed publisher
    ..No clear correlation was established between IAC numbers and the presence of definitive HSCs...
  53. Stevenson N, Addley M, Ryan E, Boyd C, Carroll H, Paunovic V, et al. CCL11 blocks IL-4 and GM-CSF signaling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signaling expression. J Leukoc Biol. 2009;85:289-97 pubmed publisher
  54. Sioud M, Fløisand Y. NOD2/CARD15 on bone marrow CD34+ hematopoietic cells mediates induction of cytokines and cell differentiation. J Leukoc Biol. 2009;85:939-46 pubmed publisher
    ..Although the best-known function of NLRs involves mature cells, our data highlight for the first time the functionality of these receptors in human BM CD34+ hematopoietic cells...
  55. Nakata Y, Shetzline S, Sakashita C, Kalota A, Rallapalli R, Rudnick S, et al. c-Myb contributes to G2/M cell cycle transition in human hematopoietic cells by direct regulation of cyclin B1 expression. Mol Cell Biol. 2007;27:2048-58 pubmed
  56. Stephens D, Townsend L, Hoff J. Interplanetary crew dose estimates for worst case solar particle events based on historical data for the Carrington flare of 1859. Acta Astronaut. 2005;56:969-74 pubmed
    ..These estimated doses are life threatening unless substantial shielding is provided...
  57. Stachura D, Svoboda O, Campbell C, Espin Palazon R, Lau R, Zon L, et al. The zebrafish granulocyte colony-stimulating factors (Gcsfs): 2 paralogous cytokines and their roles in hematopoietic development and maintenance. Blood. 2013;122:3918-28 pubmed publisher
    ..These findings may inform how hematopoietic cytokines evolved following the diversification of teleosts and mammals from a common ancestor...
  58. Lum J, Bui T, Gruber M, Gordan J, DeBerardinis R, Covello K, et al. The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev. 2007;21:1037-49 pubmed
    ..Together, these data suggest that HIF-1alpha contributes to the regulation of growth factor-stimulated glucose metabolism even in the absence of hypoxia...
  59. Reppe S, Stilgren L, Abrahamsen B, Olstad O, Cero F, Brixen K, et al. Abnormal muscle and hematopoietic gene expression may be important for clinical morbidity in primary hyperparathyroidism. Am J Physiol Endocrinol Metab. 2007;292:E1465-73 pubmed
  60. Zhao Y, Yuan W, Cheng T. [Roles of STAT5 in hematopoietic regulation and blood diseases]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012;20:1496-500 pubmed
    ..This review discusses the regulatory role of STAT5 in hematopoietic cells and its effect on the occurrence and development of blood diseases...
  61. Rodgers K, San Antonio J, Jacenko O. Heparan sulfate proteoglycans: a GAGgle of skeletal-hematopoietic regulators. Dev Dyn. 2008;237:2622-42 pubmed publisher
  62. Fabbri M, Spizzo R, Calin G. High-throughput profiling in the hematopoietic system. Methods Mol Biol. 2010;667:79-91 pubmed publisher
    ..These techniques provide the basis for further investigations focused on the miRNAs, which are most frequently and widely differentially expressed under the different investigated conditions...
  63. Zhang Z, Tong J, Lu R, Scutt A, Goltzman D, Miao D. Therapeutic potential of non-adherent BM-derived mesenchymal stem cells in tissue regeneration. Bone Marrow Transplant. 2009;43:69-81 pubmed publisher
    ..Transplantation rescued these mice by reconstructing a hematopoietic system and repairing other damaged tissues...
  64. Yang C, Ji L, Yue W, Wang R, Li Y, Xi J, et al. [Erythropoietin gene-modified conditioned medium of human mesenchymal cells promotes hematopoietic development from human embryonic stem cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010;18:976-80 pubmed
    ..These effects were obviously higher than that of control. It is concluded that the EPO gene-modified conditioned medium of human mesenchymal cells can induce the hESCs to differentiate into hematopoietic cells...
  65. Chen T, Kambal A, Krysiak K, Walshauser M, Raju G, Tibbitts J, et al. Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice. Blood. 2011;117:1530-9 pubmed publisher
    ..2) MDS cells to gain clonal dominance in the bone marrow. Our results demonstrate that Hspa9 haploinsufficiency alters the hematopoietic progenitor pool in mice and contributes to abnormal hematopoiesis. ..
  66. Giorda E, Sibilio L, Martayan A, Feriotto G, Bianchi N, Mischiati C, et al. Modular usage of the HLA-DRA promoter in extra-hematopoietic and hematopoietic cell types of transgenic mice. FEBS J. 2005;272:3214-26 pubmed
    ..In contrast to previous results in transgenic mice expressing murine class II transgenes, we were unable to generate reproducible patterns of HLA-DRA expression in B cells...
  67. Huttenhuis H, Taverne Thiele A, Grou C, Bergsma J, Saeij J, Nakayasu C, et al. Ontogeny of the common carp (Cyprinus carpio L.) innate immune system. Dev Comp Immunol. 2006;30:557-74 pubmed