leukocyte disorders


Summary: Disordered formation of various types of leukocytes or an abnormal accumulation or deficiency of these cells.

Top Publications

  1. Dinauer M. Disorders of neutrophil function: an overview. Methods Mol Biol. 2007;412:489-504 pubmed publisher
    ..Diagnostic tests and treatment approaches are also summarized for each neutrophil disorder. ..
  2. Crahes M, Saugier Veber P, Patrier S, Aziz M, Pirot N, Brasseur Daudruy M, et al. Foetal presentation of cartilage hair hypoplasia with extensive granulomatous inflammation. Eur J Med Genet. 2013;56:365-70 pubmed publisher
    ..726_727insCTCACTACTC) was detected. The founder mutation was inherited from the father, and the novel mutation from the mother. To our knowledge, this case report represents the first detailed foetal analysis described in the literature. ..
  3. Kyono W, Coates T. A practical approach to neutrophil disorders. Pediatr Clin North Am. 2002;49:929-71, viii pubmed
    ..Also included is a detailed discussion of some specific primary neutrophil syndromes at the end of each section. Focus is placed on specific disorders that are clinically common or particularly instructive...
  4. Tang A, Balzli C, Caballero A, McCormick C, Taylor S, O Callaghan R. Staphylococcus aureus infection of the rabbit cornea following topical administration. Curr Eye Res. 2012;37:1075-83 pubmed publisher
    ..To determine the ability of diverse S. aureus strains to infect the rabbit cornea following topical inoculation, with special emphasis on a strain of unusual virulence...
  5. Morais A, Lima B, Peixoto M, Melo N, Alves H, Marques J, et al. Annexin A11 gene polymorphism (R230C variant) and sarcoidosis in a Portuguese population. Tissue Antigens. 2013;82:186-91 pubmed publisher
    ..Given the role of annexin A11 in cell division, apoptosis and neutrophil function, this polymorphism may affect key elements of granulomatous and interstitial inflammation in sarcoidosis. ..
  6. Wimazal F, Germing U, Kundi M, Noesslinger T, Blum S, Geissler P, et al. Evaluation of the prognostic significance of eosinophilia and basophilia in a larger cohort of patients with myelodysplastic syndromes. Cancer. 2010;116:2372-81 pubmed publisher
    ..However, although the prognostic value of neutropenia, thrombocytopenia, and monocytosis have been documented, little is known about the impact of eosinophils and basophils...
  7. Hager M, Cowland J, Borregaard N. Neutrophil granules in health and disease. J Intern Med. 2010;268:25-34 pubmed publisher
    ..This is largely controlled by gene transcription. ..
  8. Lins K, Vale M, Ribeiro R, Costa Lotufo L. Proinflammatory activity of an alginate isolated from Sargassum vulgare. Carbohydr Polym. 2013;92:414-20 pubmed publisher
    ..Our data suggest that SVHV has proinflammatory activity dependent of the activation of resident cells, being the macrophages the main cells involved...
  9. Tsilidis K, Rohrmann S, McGlynn K, Nyante S, López D, Bradwin G, et al. Association between endogenous sex steroid hormones and inflammatory biomarkers in US men. Andrology. 2013;1:919-28 pubmed publisher
    ..03; p-trend, 0.04), but not with CRP. These cross-sectional findings are consistent with the hypothesis that higher androgen and lower oestrogen concentrations may have an anti-inflammatory effect in men. ..

More Information


  1. Mascalchi M, Moretti M, Della Nave R, Lolli F, Tessa C, Carlucci G, et al. Longitudinal evaluation of leukoaraiosis with whole brain ADC histograms. Neurology. 2002;59:938-40 pubmed
    ..008) and brain volume index (BVI) was decreased (p = 0.006). WB-ADC histogram and BVI are sensitive to leukoaraiosis and might be considered for monitoring progression of the disease. ..
  2. Herrero B, de la Fuente J, Aleo E, Carceller F, Lassaletta A, Orellana M, et al. Spontaneous resolution of hypereosinophilic syndrome in an infant without treatment. J Pediatr Hematol Oncol. 2012;34:450-2 pubmed publisher
    ..The final diagnosis was undefined HES. Repeated measurements of blood eosinophil counts, monitoring of clonal T cells, and observation of skin lesions and organ involvement were carefully performed as an outpatient. ..
  3. Smellie W, Forth J, Smart S, Galloway M, Irving W, Bareford D, et al. Best practice in primary care pathology: review 7. J Clin Pathol. 2007;60:458-65 pubmed
    ..The recommendations are not standards, but form a guide to be set in the clinical context. Most are consensus based rather than evidence based. They will be updated periodically to take account of new information. ..
  4. Nittala S, Subbarao G, Maheshwari A. Evaluation of neutropenia and neutrophilia in preterm infants. J Matern Fetal Neonatal Med. 2012;25:100-3 pubmed publisher
    ..Neutrophil counts should be carefully evaluated in premature neonates. Maternal and perinatal history, physical examination, and a limited laboratory assessment is usually adequate for making a diagnosis in most infants. ..
  5. Nauseef W. Diagnostic assays for myeloperoxidase deficiency. Methods Mol Biol. 2007;412:525-30 pubmed publisher
    ..Immunoblotting of the isolated leukocytes for MPO provides additional information, supplying insight into the molecular basis of the observed absence of functional enzyme. ..
  6. Lerchenberger M, Uhl B, Stark K, Zuchtriegel G, Eckart A, Miller M, et al. Matrix metalloproteinases modulate ameboid-like migration of neutrophils through inflamed interstitial tissue. Blood. 2013;122:770-80 pubmed publisher
    ..By contrast, neutrophil interstitial migration strictly relies on actin polymerization and does not require the pericellular degradation of collagen fibers but is modulated by MMPs. ..
  7. Sapey E, Greenwood H, Walton G, Mann E, Love A, Aaronson N, et al. Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence. Blood. 2014;123:239-48 pubmed publisher
    ..Targeting PI3K signaling may therefore offer a new strategy in improving neutrophil functions during infections and reduce inappropriate inflammation in older patients. ..
  8. Cartwright G, Athens J, Wintrobe M. THE KINETICS OF GRANULOPOIESIS IN NORMAL MAN. Blood. 1964;24:780-803 pubmed
  9. Kimura G, Ueda K, Eto S, Watanabe Y, Masuko T, Kusama T, et al. Toll-like receptor 3 stimulation causes corticosteroid-refractory airway neutrophilia and hyperresponsiveness in mice. Chest. 2013;144:99-105 pubmed publisher
  10. Liu G, Hu X, Sun B, Yang T, Shi J, Zhang L, et al. Phosphatase Wip1 negatively regulates neutrophil development through p38 MAPK-STAT1. Blood. 2013;121:519-29 pubmed publisher
    ..Thus, our findings identify a previously unrecognized p53-independent function of Wip1 as a cell type-specific negative regulator of neutrophil generation and homeostasis through limiting the p38 MAPK-STAT1 pathway. ..
  11. Ahmed S, Ibrahim U. Significance of haemoglobin-S in the pathogenesis of hyperleucocytic syndromes in Nigerian patients with chronic myeloid leukaemia. Eur J Haematol. 2007;79:174-6 pubmed
  12. Santoni M, Buti S, Conti A, Porta C, Procopio G, Sternberg C, et al. Prognostic significance of host immune status in patients with late relapsing renal cell carcinoma treated with targeted therapy. Target Oncol. 2015;10:517-22 pubmed publisher
    ..A better characterization of baseline immunological impairment may optimize the management of this RCC subpopulation. ..
  13. Nabi A, Islam L, Rahman M, Biswas K. Polymorphonuclear neutrophil dysfunctions in streptozotocin-induced type 1 diabetic rats. J Biochem Mol Biol. 2005;38:661-7 pubmed
    ..These data clearly indicate that PMN functions are altered in the streptozotocin (STZ)-induced diabetic rats, and hyperglycemia may be the cause for the impairment of their functions leading to many infectious episodes. ..
  14. Taur D, Patil R. Evaluation of antiasthmatic activity of Clitoria ternatea L. roots. J Ethnopharmacol. 2011;136:374-6 pubmed publisher
    ..Clitoria ternatea L. (Family: Fabaceae) is being used in traditional medicine for the treatment of severe bronchitis and asthma. So the aim of study was to evaluate antiasthmatic activity of ethanol extract of Clitoria ternatea roots...
  15. Ferreira R, Matsui T, Gomides L, Godin A, Menezes G, de Matos Coelho M, et al. Niacin inhibits carrageenan-induced neutrophil migration in mice. Naunyn Schmiedebergs Arch Pharmacol. 2013;386:533-40 pubmed publisher
    ..Further inhibition of chemoattractants leads to impairment of leukocyte rolling and adherence to the vascular endothelium in the microcirculation of inflamed tissues. ..
  16. Hajishengallis E, Hajishengallis G. Neutrophil homeostasis and periodontal health in children and adults. J Dent Res. 2014;93:231-7 pubmed publisher
    ..This suggests the operation of as-yet-unknown molecular mechanisms, although the available body of evidence leaves no doubt that neutrophils are integral to periodontal tissue homeostasis and health. ..
  17. Suzuki O, Mizukami K, Etori M, Sogawa Y, Takagi N, Tsuchida H, et al. Evaluation of the therapeutic index of a novel phosphodiesterase 4B-selective inhibitor over phosphodiesterase 4D in mice. J Pharmacol Sci. 2013;123:219-26 pubmed
    ..0 and 0.5, respectively). In conclusion, the TI(Neu) of compound A was not superior compared to that of roflumilast in spite of its high selectivity for PDE4B over PDE4D in mice. ..
  18. Wynn R, Sood M, Theilgaard Monch K, Jones C, Gombart A, Gharib M, et al. Intractable diarrhoea of infancy caused by neutrophil specific granule deficiency and cured by stem cell transplantation. Gut. 2006;55:292-3 pubmed
  19. Frasch S, Fernandez Boyanapalli R, Berry K, Murphy R, Leslie C, Nick J, et al. Neutrophils regulate tissue Neutrophilia in inflammation via the oxidant-modified lipid lysophosphatidylserine. J Biol Chem. 2013;288:4583-93 pubmed publisher
  20. Rampling M. Hyperviscosity as a complication in a variety of disorders. Semin Thromb Hemost. 2003;29:459-65 pubmed
    ..The details of the causes of the hyperviscosity, the symptoms that result, and the forms of treatment are discussed...
  21. Fogli L, Sundrud M, Goel S, Bajwa S, Jensen K, Derudder E, et al. T cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia. J Immunol. 2013;191:3100-11 pubmed publisher
  22. Shibutani T, Gen K, Shibata M, Horiguchi Y, Kondo N, Iwayama Y. Long-term follow-up of periodontitis in a patient with Chédiak-Higashi syndrome. A case report. J Periodontol. 2000;71:1024-8 pubmed
    ..However, the mobility of teeth and the inflammation of periodontal tissue progressed. This CHS patient presented with periodontal disease of extremely early onset, which was resistant to periodontal treatment...
  23. Rot A, McKimmie C, Burt C, Pallas K, Jamieson T, Pruenster M, et al. Cell-autonomous regulation of neutrophil migration by the D6 chemokine decoy receptor. J Immunol. 2013;190:6450-6456 pubmed publisher
    ..These data have important implications for our understanding of the roles for D6 in regulating inflammation and for our understanding of the control of spatial positioning of leukocytes at inflamed sites...
  24. Gratacap R, Rawls J, Wheeler R. Mucosal candidiasis elicits NF-?B activation, proinflammatory gene expression and localized neutrophilia in zebrafish. Dis Model Mech. 2013;6:1260-70 pubmed publisher
    ..This is the first system to model host response to mucosal infection in the juvenile zebrafish, and offers unique opportunities to investigate the tripartite interactions of C. albicans, epithelium and immune cells in an intact host. ..
  25. Hall J, Sendek R, Chinn R, Bailey D, Thonstad K, Wang Y, et al. Higher whole-blood selenium is associated with improved immune responses in footrot-affected sheep. Vet Res. 2011;42:99 pubmed publisher
    ..Sheep FR is associated with depressed immune responses to a novel protein, which may be partly restored by improving WB-Se status (> 250 ng/mL)...
  26. Yancey P, Ding Y, Fan D, Blakemore J, Zhang Y, Ding L, et al. Low-density lipoprotein receptor-related protein 1 prevents early atherosclerosis by limiting lesional apoptosis and inflammatory Ly-6Chigh monocytosis: evidence that the effects are not apolipoprotein E dependent. Circulation. 2011;124:454-64 pubmed publisher
    ..Thus, our objective was to determine whether the atheroprotective effects of LRP1 require interaction with apoE, one of its ligands with multiple beneficial effects...
  27. Schiwon M, Weisheit C, Franken L, Gutweiler S, Dixit A, Meyer Schwesinger C, et al. Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium. Cell. 2014;156:456-68 pubmed publisher
    ..These findings identify helper macrophages and TNF as critical regulators in innate immunity against bacterial infections in epithelia. ..
  28. Heineke M, van der Steen L, Korthouwer R, Hage J, Langedijk J, Benschop J, et al. Peptide mimetics of immunoglobulin A (IgA) and Fc?RI block IgA-induced human neutrophil activation and migration. Eur J Immunol. 2017;47:1835-1845 pubmed publisher
    ..In conclusion, a cream containing IgA or Fc?RI peptide mimetics, which block IgA-induced neutrophil activation and migration in the skin may have therapeutic potential for patients with IgA-mediated blistering skin diseases...
  29. Lidgren L. Chronic inflammation, joint replacement and malignant lymphoma. J Bone Joint Surg Br. 2008;90:7-10 pubmed
    ..This paper considers the increased risk of the development of lymphoma in patients with chronic inflammatory disease who undergo metal-on-metal arthroplasty...
  30. Rothe G, Klouche M. Phagocyte function. Methods Cell Biol. 2004;75:679-708 pubmed
  31. Broides A, Yerushalmi B, Levy R, Hadad N, Kaplun N, Tanner S, et al. Imerslund-Grasbeck syndrome associated with recurrent aphthous stomatitis and defective neutrophil function. J Pediatr Hematol Oncol. 2006;28:715-9 pubmed
    ..We demonstrated that serum vitamin B(12) deficiency is associated with a neutrophil chemotactic defect and RAS in IGS patients. We suggest that the RAS observed in these patients is due to this defect...
  32. Castriconi R, Dondero A, Cantoni C, Della Chiesa M, Prato C, Nanni M, et al. Functional characterization of natural killer cells in type I leukocyte adhesion deficiency. Blood. 2007;109:4873-81 pubmed
  33. Kaya H, Nakamura S, Okafuji K, Terasaki Y, Maeno K, Tanaka N, et al. Trisomy 14 with thrombocytosis and monocytosis. Acta Haematol. 2000;103:206-9 pubmed
    ..Hydroxyurea, cytarabine or aclarubicin in low doses may be the treatment of choice for trisomy 14 patients with respect to the patients' quality of life...
  34. Yang S, Chung P, Ho C, Kuo C, Hung M, Huang Y, et al. Propofol inhibits superoxide production, elastase release, and chemotaxis in formyl peptide-activated human neutrophils by blocking formyl peptide receptor 1. J Immunol. 2013;190:6511-9 pubmed publisher
    ..Considering the importance of N-formyl peptides in inflammatory processes, our data indicate that propofol may have therapeutic potential to attenuate neutrophil-mediated inflammatory diseases by blocking FPR1...
  35. Smith C. Disease models for every field: workshop on the molecular basis of human congenital lymphocyte disorders. EMBO Rep. 2002;3:516-20 pubmed
  36. Meany H, Seibel N, Sun J, Finklestein J, Sato J, Kelleher J, et al. Phase 2 trial of recombinant tumor necrosis factor-alpha in combination with dactinomycin in children with recurrent Wilms tumor. J Immunother. 2008;31:679-83 pubmed publisher
    ..The combination was well tolerated. Although grade 3/4 adverse events were reported, dose adjustments were not required. Toxicities resolved without significant interventions...
  37. Wong M, Schlaggar B, Landt M. Postictal cerebrospinal fluid abnormalities in children. J Pediatr. 2001;138:373-7 pubmed
    ..To determine the frequency and characteristics of seizure-induced cerebrospinal fluid (CSF) abnormalities in children and to identify potential alternative causes of these findings...
  38. Elloumi H, Holland S. Diagnostic assays for chronic granulomatous disease and other neutrophil disorders. Methods Mol Biol. 2007;412:505-23 pubmed publisher
    ..The assays are relatively simple to perform, cost-effective, and can be performed with equipment available in most laboratories...
  39. Damasceno S, Oliveira F, Carvalho N, Brito C, Silva I, Sousa F, et al. Carvacryl acetate, a derivative of carvacrol, reduces nociceptive and inflammatory response in mice. Life Sci. 2014;94:58-66 pubmed publisher
    ..The present study aimed to investigate the potential anti-inflammatory and anti-nociceptive effects of carvacryl acetate, a derivative of carvacrol, in mice...
  40. Jones A, Gulley M, Freedman P. Necrotizing ulcerative stomatitis in human immunodeficiency virus-seropositive individuals: a review of the histopathologic, immunohistochemical, and virologic characteristics of 18 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;89:323-32 pubmed
    ..The purpose of this retrospective study was to delineate the histopathologic, immunohistochemical, and virologic characteristics of 18 cases of necrotizing ulcerative stomatitis...
  41. McCully R, Cooper L, Schreiter S. Coronary artery spasm in lymphocytic myocarditis: a rare cause of acute myocardial infarction. Heart. 2005;91:202 pubmed
  42. Boespflug N, Kumar S, McAlees J, Phelan J, Grimes H, Hoebe K, et al. ATF3 is a novel regulator of mouse neutrophil migration. Blood. 2014;123:2084-93 pubmed publisher
    ..Together, our data describe a dichotomous role for ATF3-mediated regulation of neutrophilic responses: inhibition of neutrophil chemokine production but promotion of neutrophil chemotaxis. ..
  43. Chehade M, Sampson H. Epidemiology and etiology of eosinophilic esophagitis. Gastrointest Endosc Clin N Am. 2008;18:33-44; viii pubmed
    ..In this article, available evidence on the epidemiology and etiology of EE is discussed...
  44. Pacheco Castro A, Martín Fernández J, Millan R, Sanal O, Allende L, Regueiro J. Toward gene therapy for human CD3 deficiencies. Hum Gene Ther. 2003;14:1653-61 pubmed
  45. McNamee L, Harmsen A. Both influenza-induced neutrophil dysfunction and neutrophil-independent mechanisms contribute to increased susceptibility to a secondary Streptococcus pneumoniae infection. Infect Immun. 2006;74:6707-21 pubmed
    ..Thus, an influenza infection of 6 days increases susceptibility to S. pneumoniae by both suppression of neutrophil function and by neutrophil-independent mechanisms such as enhanced cytokine production...
  46. Thormann N, Van De Walle G, Azab W, Osterrieder N. The role of secreted glycoprotein G of equine herpesvirus type 1 and type 4 (EHV-1 and EHV-4) in immune modulation and virulence. Virus Res. 2012;169:203-11 pubmed publisher
    ..Taken together, our results show that, in a virus background, the hypervariable region is not solely responsible for the immunomodulatory potential of EHV-1 gG...
  47. Czaikoski P, Nascimento D, Sonego F, de Freitas A, Turato W, de Carvalho M, et al. Heme oxygenase inhibition enhances neutrophil migration into the bronchoalveolar spaces and improves the outcome of murine pneumonia-induced sepsis. Shock. 2013;39:389-96 pubmed publisher
    ..These results show that heme oxygenase is involved in the pathophysiology of pneumonia-induced sepsis and suggest that HO inhibitors could be helpful for the management of this disease...
  48. Clancy R, Gleeson M, Cox A, Callister R, Dorrington M, D Este C, et al. Reversal in fatigued athletes of a defect in interferon gamma secretion after administration of Lactobacillus acidophilus. Br J Sports Med. 2006;40:351-4 pubmed
    ..Reduced concentration of IgA in the saliva and increased shedding of Epstein Barr virus (EBV) have been associated with intense training in elite athletes...
  49. Schäffer A, Klein C. Animal models of human granulocyte diseases. Hematol Oncol Clin North Am. 2013;27:129-48, ix pubmed publisher
    ..Strengths and weaknesses of each system are summarized, and clinical investigators may thus be inspired to develop further lines of research to improve diagnosis and therapy by use of the appropriate animal model system. ..
  50. Sutton A, Lawrence H, Canty K. Crohn's disease presenting as a neutrophilic dermatosis in a 5-month-old boy. Pediatr Dermatol. 2013;30:619-20 pubmed publisher
    ..Our case represents, to our knowledge, the youngest person reported with this condition in association with Crohn's disease. ..
  51. Thompson D, Orvidas L. Otorhinolaryngologic manifestations of eosinophilic esophagitis. Gastrointest Endosc Clin N Am. 2008;18:91-8; ix pubmed
    ..Team collaboration between otolaryngologists, allergists, and gastroenterologists will assure the best treatment in this select group of predisposed patients...
  52. Polesskaya O, Wong C, Lebron L, Chamberlain J, Gelbard H, Goodfellow V, et al. MLK3 regulates fMLP-stimulated neutrophil motility. Mol Immunol. 2014;58:214-22 pubmed publisher
  53. Mainwaring C, Williams M, Singer C, Lush R, Smith J, Haynes C, et al. Monocyte dysfunction in patients with multiple myeloma and lymphoplasmacytic disorders is related to serum paraprotein levels. Br J Haematol. 1999;105:948-54 pubmed
  54. Shankar A, Wang J, Rochtchina E, Yu M, Kefford R, Mitchell P. Association between circulating white blood cell count and cancer mortality: a population-based cohort study. Arch Intern Med. 2006;166:188-94 pubmed
    ..However, it is not clear whether systemic markers of inflammation predict cancer. We examined the prospective relationship between circulating white blood cell (WBC) count and cancer mortality...
  55. de Brito T, Prudêncio R, Sales A, Vieira F, Candeira S, Franco A, et al. Anti-inflammatory effect of a sulphated polysaccharide fraction extracted from the red algae Hypnea musciformis via the suppression of neutrophil migration by the nitric oxide signalling pathway. J Pharm Pharmacol. 2013;65:724-33 pubmed publisher
  56. Amanzadeh J, Reilly R. Hypophosphatemia: an evidence-based approach to its clinical consequences and management. Nat Clin Pract Nephrol. 2006;2:136-48 pubmed
    ..By contrast, patients with severe hypophosphatemia should be treated. Intravenous repletion may be considered, especially for patients who have clinical sequelae of hypophosphatemia...
  57. Swamynathan S, Buela K, KINCHINGTON P, Lathrop K, Misawa H, Hendricks R, et al. Klf4 regulates the expression of Slurp1, which functions as an immunomodulatory peptide in the mouse cornea. Invest Ophthalmol Vis Sci. 2012;53:8433-46 pubmed publisher
    ..The secreted Ly6/uPAR-related protein-1 (Slurp1), associated with the hyperkeratotic disorder mal de Meleda, is abundantly expressed in corneas. Here, we examine its corneal expression and functions...
  58. Katzka D. Demographic data and symptoms of eosinophilic esophagitis in adults. Gastrointest Endosc Clin N Am. 2008;18:25-32; viii pubmed
    ..A careful history with attention to detail and a compilation of compatible characteristics is key to the clinician's diagnosing eosinophilic esophagitis in an adult...
  59. Kliem H, Rodler D, Ulbrich S, Sinowatz F, Berisha B, Meyer H, et al. Dexamethasone-induced eosinopenia is associated with lower progesterone production in cattle. Reprod Domest Anim. 2013;48:137-48 pubmed publisher
    ..We assume from our data that the migration of eosinophilic cells into the early CL is not an essential, but an important stimulus for angiogenesis during early CL development in cattle...
  60. Goon P, Watson T, Lip G. Circulating endothelial cells in obstructive sleep apnea: an important methodological lesson. Am J Respir Crit Care Med. 2007;175:1346; author reply 1347 pubmed
  61. Kiemer A, Fürst R, Vollmar A. Vasoprotective actions of the atrial natriuretic peptide. Curr Med Chem Cardiovasc Hematol Agents. 2005;3:11-21 pubmed
    ..In this context, we will highlight the physiological and pharmacological relevance of NPs, particularly ANP, as endogenous vasoprotective agents...
  62. Guerrero A, Zarpelon A, Zaperlon A, Vieira S, Pinto L, Ferreira S, et al. The role of PAF/PAFR signaling in zymosan-induced articular inflammatory hyperalgesia. Naunyn Schmiedebergs Arch Pharmacol. 2013;386:51-9 pubmed publisher
    ..Finally, targeting PAF action (e.g., with a PAFR antagonist) might provide a useful therapeutic approach to inhibit articular inflammatory hyperalgesia...
  63. Buttaci C. Erythromelalgia: a case report and literature review. Pain Med. 2006;7:534-8 pubmed
    ..This paper describes the unique syndrome of erythromelalgia through a case report and literature review...
  64. Mao H, Wu H, Bu L, Zhou Y, Sun J, Sun P. [Relationship between electroacupuncture-induced regulatory effect on leukocytes and the caliber of splenic sinusoid basal lamina eyehole on rabbits]. Zhen Ci Yan Jiu. 2008;33:291-5 pubmed
    ..To study the underlining mechanism of electroacupuncture (EA) in regulating leukocyte counts in the rabbit...
  65. Kuskonmaz B, Unal S, Cördükcü E, Aydin H, Coskun T, Gurgey A, et al. Lymphocytic vacuolization in sialic acid storage disease. Am J Hematol. 2008;83:821 pubmed
  66. Balague C, Pont M, Prats N, Godessart N. Profiling of dihydroorotate dehydrogenase, p38 and JAK inhibitors in the rat adjuvant-induced arthritis model: a translational study. Br J Pharmacol. 2012;166:1320-32 pubmed publisher
  67. Dormandy A. Pathophysiology of venous leg ulceration. Int J Microcirc Clin Exp. 1997;17 Suppl 1:2-5 pubmed
    ..The net result is impairment of the potential for healing and hence ulceration...
  68. Lainey E, Ogier H, Fenneteau O. Vacuolation of neutrophils and acanthocytosis in child with medium chain acyl-CoA dehydrogenase deficiency. Br J Haematol. 2008;140:595 pubmed publisher
  69. Fernandez R, Boxer L, Suchard S. Beta2 integrins are not required for tyrosine phosphorylation of paxillin in human neutrophils. J Immunol. 1997;159:5568-75 pubmed
    ..These results indicate that ECM-beta2 integrin-mediated signaling initiates the FAK/paxillin signaling pathway(s), while TSP-mediated signaling results in paxillin phosphorylation independent of FAK phosphorylation...
  70. Luo H. A dual regulator of neutrophil recruitment. Blood. 2014;123:1983-5 pubmed publisher
  71. Mendonça M, Souto F, Micheli D, Alves Filho J, Cunha F, Murta E, et al. Mechanisms affecting neutrophil migration capacity in breast cancer patients before and after chemotherapy. Cancer Chemother Pharmacol. 2014;73:317-24 pubmed publisher
    ..To investigate the mechanisms affecting neutrophil migration capacity in breast cancer patients before and after chemotherapy...
  72. Lee K, Suh B, Kim J, Lee W, Kim S, Kim Y, et al. Varying expression levels of colony stimulating factor receptors in disease states and different leukocytes. Exp Mol Med. 2000;32:210-5 pubmed
  73. Yang T, Chen C, Lin W, Lin Y, Tseng P, Hsieh C, et al. Glycogen synthase kinase-3? inactivation is an intracellular marker and regulator for endotoxemic neutrophilia. J Mol Med (Berl). 2013;91:207-17 pubmed publisher
    ..These results demonstrate that the molecular basis of endotoxemic neutrophilia is through a direct action on neutrophils involving GSK-3? inactivation to prevent constitutive apoptosis...
  74. Balderramo D, Ricchi B, Marun S, Scaliter G, Alonso M. Sebastian syndrome: report of the first case in a South American family. Haematologica. 2003;88:ECR17 pubmed
    ..In these cases, the history, carefully peripheral smear exam, immunocytochemistry and electronic microscopy will be of great help. Differentiation ITP with SS is important to avoid unnecessary diagnostic studies and treatments...
  75. Condron C, Toomey D, Casey R, Shaffii M, Creagh T, Bouchier Hayes D. Neutrophil bactericidal function is defective in patients with recurrent urinary tract infections. Urol Res. 2003;31:329-34 pubmed
    ..This reduced neutrophil function may result in defective bacterial clearance and lead to susceptibility to recurrent infection...
  76. Muller T, Jörres R, Scharrer E, Hessel H, Nowak D, Radon K. Acute blood neutrophilia induced by short-term compost dust exposure in previously unexposed healthy individuals. Int Arch Occup Environ Health. 2006;79:477-82 pubmed
    ..The purpose of this study was to examine whether a single exposure at a biowaste composting facility could also exert systemic effects in healthy volunteers not previously exposed to organic dust from such facilities...
  77. Tomin D. Preoperative preparation of the patient with the abnormalities of red and white blood cells. Acta Chir Iugosl. 2011;58:77-82 pubmed
  78. Kamp V, Pillay J, Lammers J, Pickkers P, Ulfman L, Koenderman L. Human suppressive neutrophils CD16bright/CD62Ldim exhibit decreased adhesion. J Leukoc Biol. 2012;92:1011-20 pubmed publisher
    ..Modulation of this process is a potential target to manipulate inflammation because potentiation of this immune suppression might aid in anti-inflammatory therapy...