hemorrhagic disorders


Summary: Spontaneous or near spontaneous bleeding caused by a defect in clotting mechanisms (BLOOD COAGULATION DISORDERS) or another abnormality causing a structural flaw in the blood vessels (HEMOSTATIC DISORDERS).

Top Publications

  1. Agren A, Wiman B, Stiller V, Lindmarker P, Sten Linder M, Carlsson A, et al. Evaluation of low PAI-1 activity as a risk factor for hemorrhagic diathesis. J Thromb Haemost. 2006;4:201-8 pubmed
    ..Prospective studies of the epidemiology and clinical significance of low plasminogen activator inhibitor type 1 (PAI-1) activity are lacking...
  2. Leblebisatan G, Bay A, Karakus S, Kekilli M, Haznedaroglu I. Topical Ankaferd hemostat application for the management of oral cavity bleedings in children with hemorrhagic diathesis. Blood Coagul Fibrinolysis. 2012;23:494-7 pubmed publisher
    ..Ankaferd is effective for oral bleedings of children with bleeding diathesis especially when other measures have failed...
  3. Peyvandi F, Cattaneo M, Inbal A, de Moerloose P, Spreafico M. Rare bleeding disorders. Haemophilia. 2008;14 Suppl 3:202-10 pubmed publisher
    ..Finally, the update of the Rare Bleeding Disorders Database will be presented by Dr Spreafico...
  4. Karimi M, Haghpanah S, Amirhakimi A, Afrasiabi A, Dehbozorgian J, Nasirabady S. Spectrum of inherited bleeding disorders in southern Iran, before and after the establishment of comprehensive coagulation laboratory. Blood Coagul Fibrinolysis. 2009;20:642-5 pubmed publisher
  5. McMahon C, Smith J, Goonan C, Byrne M, Smith O. The role of primary prophylactic factor replacement therapy in children with severe factor X deficiency. Br J Haematol. 2002;119:789-91 pubmed
    ..All children have normal joint function, suggesting that prophylaxis commenced early in life reduces the incidence of arthropathy and improves quality of life. ..
  6. Ontachi Y, Asakura H, Omote M, Yoshida T, Matsui O, Nakao S. Kasabach-Merritt syndrome associated with giant liver hemangioma: the effect of combined therapy with danaparoid sodium and tranexamic acid. Haematologica. 2005;90 Suppl:ECR29 pubmed
    ..The therapy did not restrict the behavior of the patient by continuous drip and angiography could be performed without bleeding. Such therapy may be beneficial in chronic DIC with activation of fibrinolysis. ..
  7. Ozgonenel B, Rajpurkar M, Lusher J. How do you treat bleeding disorders with desmopressin?. Postgrad Med J. 2007;83:159-63 pubmed
    ..Clinicians need to become familiar with the use of this drug that has become a home medication for many patients with inherited bleeding disorders. ..
  8. Mori N, Toyokawa K, Teramura M, Masuda M, Motoji T. [Recombinant factor VIII-CVP therapy for acquired factor VIII inhibitors]. Rinsho Ketsueki. 2007;48:581-5 pubmed
    ..Disappearance of inhibitors was achieved after three to four courses of therapy without subsequent recurrence. Recombinant factor VIII-CVP therapy is safe and effective in the eradication of factor VIII inhibitors. ..
  9. Salvati F, Liani M. Role of platelet surface receptor abnormalities in the bleeding and thrombotic diathesis of uremic patients on hemodialysis and peritoneal dialysis. Int J Artif Organs. 2001;24:131-5 pubmed
    ..Finally the abnormalities of platelet surface receptors may play a main role in the hemostatic alterations of uremic patients. ..

More Information

Publications115 found, 100 shown here

  1. Mondal R, Mann U, Sharma M. Osteogenesis imperfecta with bleeding diathesis. Indian J Pediatr. 2003;70:95-6 pubmed
    ..Here we come across a rare case of Sillence type IB Osteogenesis imperfecta with bleeding in the form of repeated epistaxis and petechial rash, which seem to have a collagenous link. ..
  2. Lee G, Lee J, Choi S, Kim S, Seol M, Kim W, et al. Hemorrhagic cystitis following allogeneic hematopoietic cell transplantation. J Korean Med Sci. 2003;18:191-5 pubmed
    ..36-8.39). Late-onset HC, which occurred beyond 3 weeks after allo-HCT, was more frequently associated with GVHD than early-onset HC (p=0.007). Our data suggest that a portion of late-onset HC might be a manifestation of GVHD. ..
  3. Lederer D, Kawut S, Sonett J, Vakiani E, Seward S, White J, et al. Successful bilateral lung transplantation for pulmonary fibrosis associated with the Hermansky-Pudlak syndrome. J Heart Lung Transplant. 2005;24:1697-9 pubmed
    ..Lung transplantation is a viable therapeutic option in patients with pulmonary fibrosis and only a mild bleeding diathesis associated with HPS...
  4. Mokhtar G, Tantawy A, Adly A, Telbany M, El Arab S, Ismail M. A longitudinal prospective study of bleeding diathesis in Egyptian pediatric patients: single-center experience. Blood Coagul Fibrinolysis. 2012;23:411-8 pubmed publisher
    ..Analysis of the clinico-epidemiological data of patients with bleeding disorders is a useful tool for monitoring and improving their quality of care. ..
  5. Menell J, Cesarman G, Jacovina A, McLaughlin M, Lev E, Hajjar K. Annexin II and bleeding in acute promyelocytic leukemia. N Engl J Med. 1999;340:994-1004 pubmed
    ..Abnormally high levels of expression of annexin II on APL cells increase the production of plasmin, a fibrinolytic protein. Overexpression of annexin II may be a mechanism for the hemorrhagic complications of APL. ..
  6. Akhavan S, De Cristofaro R, Peyvandi F, Lavoretano S, Landolfi R, Mannucci P. Molecular and functional characterization of a natural homozygous Arg67His mutation in the prothrombin gene of a patient with a severe procoagulant defect contrasting with a mild hemorrhagic phenotype. Blood. 2002;100:1347-53 pubmed
    ..The mild hemorrhagic phenotype might be explained by abnormalities that ultimately counterbalance each other. ..
  7. Bargetzi M. [Etiology and treatment of thrombocytopenia]. Ther Umsch. 2004;61:172-7 pubmed
    ..In the management of immune thrombocytopenic purpura, the most common form of thrombocytopenia in adults, the goal is to avoid hemorrhages and not to increase the platelet value to normal. ..
  8. Takakura K. [Hypermenorrhea (menorrhagia) and dysmenorrhea]. Nihon Rinsho. 2006;Suppl 2:399-402 pubmed
  9. Gaudiani J, Kashuk J, Chu E, Narayanan V, Mehler P. The use of thrombelastography to determine coagulation status in severe anorexia nervosa: a case series. Int J Eat Disord. 2010;43:382-5 pubmed publisher
    ..We report on three cases of young women with severe AN and weakness, hospitalized for closely monitored refeeding, in whom the thromboelastogram was used to evaluate the coagulation status of the patient and assist in guiding therapy. ..
  10. D Andrea G, Margaglione M. Glanzmann's thrombasthenia: modulation of clinical phenotype by alpha2C807T gene polymorphism. Haematologica. 2003;88:1378-82 pubmed
  11. Favaloro E. Investigating people with mucocutaneous bleeding suggestive of primary hemostatic defects: a low likelihood of a definitive diagnosis?. Haematologica. 2007;92:292-6 pubmed
  12. Music I, Novak M, Acham Roschitz B, Muntean W. Screening for haemorrhagic disorders in paediatric patients by means of a questionnaire. Hamostaseologie. 2009;29 Suppl 1:S87-9 pubmed
    ..82, but the positive predictive value was only 0.52. Our small study shows, that a questionnaire yields good results to exclude a haemostatic disorder, but is not a sensitive tool to identify such a disorder. ..
  13. Broze G, Girard T. Factor V, tissue factor pathway inhibitor, and east Texas bleeding disorder. J Clin Invest. 2013;123:3710-2 pubmed publisher
    ..This interaction leads to an approximately 10-fold increase in the level of TFPI? circulating in plasma and a resultant anticoagulant effect that produces a hemorrhagic diathesis. ..
  14. Sakai T, Shiraki K, Deguchi M, Itoh N, Konishi T, Takase K, et al. Hepatocellular carcinoma associated with hemophagocytic syndrome. Hepatogastroenterology. 2001;48:1464-6 pubmed
    ..Hemophagocytic syndrome related to a solid tumor very rarely occurs. However, when malignant tumor is accompanied by pancytopenia, hemophagocytic syndrome should be considered. ..
  15. Fernandez J, Sadaniantz B, Sadaniantz A. Review of antithrombotic agents used for acute coronary syndromes in renal patients. Am J Kidney Dis. 2003;42:446-55 pubmed
    ..Clinical data regarding the optimum management of ACSs in renal patients are still lacking. In this article, we review the available data on the use of antithrombotic agents, particularly in patients with renal impairment. ..
  16. Waller E. Hemorrhagic cystitis after hematopoietic stem cell trans-plantation: much progress and many remaining issues. Chin Med J (Engl). 2007;120:1671 pubmed
  17. Rodeghiero F, Ruiz Saez A, Bolton Maggs P, Hayward C, Nair S, Srivastava A. Laboratory issues in bleeding disorders. Haemophilia. 2008;14 Suppl 3:93-103 pubmed publisher
    ..The most needed areas concern VWD and platelet function disorders, which suffer from inadequate diagnostic standardization, hampering widespread diagnostic capability in both Western and non-Western countries. ..
  18. Aboumarzouk O, Somani B, Monga M. Flexible ureteroscopy and holmium:YAG laser lithotripsy for stone disease in patients with bleeding diathesis: a systematic review of the literature. Int Braz J Urol. 2012;38:298-305; discussion 306 pubmed
    ..Retrograde stone treatment using ureteroscopy and holmium laser lithotripsy can be safely performed in patients with bleeding diathesis with a low complication rate. ..
  19. Acharya S. Rare bleeding disorders in children: identification and primary care management. Pediatrics. 2013;132:882-92 pubmed publisher
    ..When available, specific purified plasma-derived or recombinant factor concentrates, rather than fresh frozen plasma or cryoprecipitate, are the treatment of choice. ..
  20. Reisch N, Roehnisch T, Sadeghi M, Greiner L, Regenbogen C, Rieger J, et al. AML M1 presenting with recurrent acute large arterial vessel thromboembolism. Leuk Res. 2007;31:869-71 pubmed
  21. Wang H, Chen S, Chen Y, Wang H, Wu H, Tang H, et al. The role of Tyro 3 subfamily receptors in the regulation of hemostasis and megakaryocytopoiesis. Haematologica. 2007;92:643-50 pubmed
    ..The Tyro 3 RTK subfamily plays important roles in regulating hemostasis, megakaryocytopoiesis and platelet function. ..
  22. Mumford A, Dawood B, Daly M, Murden S, Williams M, Protty M, et al. A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis. Blood. 2010;115:363-9 pubmed publisher
    ..Our demonstration that the D304N substitution causes clinically significant platelet dysfunction by reducing ligand binding establishes the importance of the NPXXY motif for TxA(2)R function in vivo. ..
  23. Casonato A, Sponga S, Pontara E, Cattini M, Basso C, Thiene G, et al. von Willebrand factor abnormalities in aortic valve stenosis: Pathophysiology and impact on bleeding. Thromb Haemost. 2011;106:58-66 pubmed publisher
  24. Ozier Y, Cadic A, Dovergne A. [Management of hemostasis abnormalities in patients with liver failure]. Transfus Clin Biol. 2013;20:249-54 pubmed publisher
  25. Gabbeta J, Vaidyula V, Dhanasekaran D, Rao A. Human platelet Galphaq deficiency is associated with decreased Galphaq gene expression in platelets but not neutrophils. Thromb Haemost. 2002;87:129-33 pubmed
  26. Harrison C, Khair K, Baxter B, Russell Eggitt I, Hann I, Liesner R. Hermansky-Pudlak syndrome: infrequent bleeding and first report of Turkish and Pakistani kindreds. Arch Dis Child. 2002;86:297-301 pubmed
    ..The occurrence of Turkish and Pakistani kindreds with HPS is novel and follow up for long term complications described in Puerto Rican patients as well as genetic analysis is ongoing. ..
  27. Kahl B, Schwartz B, Mosher D. Profound imbalance of pro-fibrinolytic and anti-fibrinolytic factors (tissue plasminogen activator and plasminogen activator inhibitor type 1) and severe bleeding diathesis in a patient with cirrhosis: correction by liver transplantation. Blood Coagul Fibrinolysis. 2003;14:741-4 pubmed
    ..Recognition of such patients is important, because the bleeding diathesis is an indication rather than a contraindication for orthotopic liver transplantation. ..
  28. Gachet C, Hechler B. The platelet P2 receptors in thrombosis. Semin Thromb Hemost. 2005;31:162-7 pubmed
    ..However, further studies with stronger and more selective P2 receptor antagonists are required to validate such a point of view. ..
  29. Scully C, Hobkirk J, Dios P. Dental endosseous implants in the medically compromised patient. J Oral Rehabil. 2007;34:590-9 pubmed
    ..The benefits of implants to many of these patients may outweigh any risks. However, proper informed consent is mandatory. ..
  30. Ichinose A. Hemorrhagic acquired factor XIII (13) deficiency and acquired hemorrhaphilia 13 revisited. Semin Thromb Hemost. 2011;37:382-8 pubmed publisher
    ..Products containing F13 are effective for hemostasis generally, and immunosuppressive therapy must be started immediately to eradicate anti-F13 antibodies. ..
  31. Norris J, Pratt S, Auh J, Wilson S, Clutter D, Magdesian K, et al. Investigation of a novel, heritable bleeding diathesis of Thoroughbred horses and development of a screening assay. J Vet Intern Med. 2006;20:1450-6 pubmed
    ..A flow cytometric assay of fibrinogen binding to washed platelets discriminates individuals with this platelet dysfunction and may be useful for discerning subclinical congenital or acquired platelet dysfunctions. ..
  32. Dalati M, Kudsi Z, Koussayer L, Dalati M, Mawla M. Bleeding disorders seen in the dental practice. Dent Update. 2012;39:266-8, 270 pubmed
    ..This will be followed by another article that will cover the management of congenital and acquired disorders found in the dental practice. ..
  33. Suzuki K, Hayashi T, Yahagi A, Akiba J, Tajima K, Satoh S, et al. Novel point mutation in the leucine-rich motif of the platelet glycoprotein IX associated with Bernard-Soulier syndrome. Br J Haematol. 1997;99:794-800 pubmed
  34. Imam Sghiouar N, Laude Lemaire I, Labas V, Pflieger D, Le Caer J, Caron M, et al. Subproteomics analysis of phosphorylated proteins: application to the study of B-lymphoblasts from a patient with Scott syndrome. Proteomics. 2002;2:828-38 pubmed
    ..Protein identification was achieved using a combination of mass fingerprinting and peptide identification using LC-MS/MS. ..
  35. Khakhar A, Chan N, Allan D, Chakrabarti S, McAlister V. Catastrophic microangiopathy induced by high-titre factor VIII inhibitors after liver transplantation for haemophilia A with cirrhosis. Haemophilia. 2005;11:623-8 pubmed
    ..Uncontrollable haemorrhage persisted until the recipient's death. In patients with high-titre FVIII inhibitors resilient desensitization is required before liver transplantation. ..
  36. Yilmaz D, Karapinar B, Balkan C, Akisu M, Kavakli K. Single-center experience: use of recombinant factor VIIa for acute life-threatening bleeding in children without congenital hemorrhagic disorder. Pediatr Hematol Oncol. 2008;25:301-11 pubmed publisher
    ..However, the risk of thromboembolism should be considered before this treatment is given. ..
  37. Phan H, Wisner D. Should we increase the ratio of plasma/platelets to red blood cells in massive transfusion: what is the evidence?. Vox Sang. 2010;98:395-402 pubmed
    ..The available retrospective studies raise many important questions that need to be addressed in future clinical trials. ..
  38. Bick R. Vascular thrombohemorrhagic disorders: hereditary and acquired. Clin Appl Thromb Hemost. 2001;7:178-94 pubmed
  39. Sasahara Y, Kumaki S, Ohashi Y, Minegishi M, Kano H, Bessho F, et al. Deficient activity of von Willebrand factor-cleaving protease in patients with Upshaw-Schulman syndrome. Int J Hematol. 2001;74:109-14 pubmed
    ..We detected enriched enzyme activity in a particular plasma fraction, although molecular cloning of this specific protease is needed to determine a more detailed pathogenesis and to develop new therapeutic approaches. ..
  40. Małyszko J, Małyszko J, Skrzydlewska E, Pawlak K, Mysliwiec M. Protein Z and vitamin K in kidney disease. Rocz Akad Med Bialymst. 2004;49:197-200 pubmed
    ..This phenomenon seems to be unrelated to vitamin K status in these patients. ..
  41. Kozian D, Proulle V, Nitsche A, Galitzine M, Martinez M, Schumann B, et al. Identification of genes involved in Ca2+ ionophore A23187-mediated apoptosis and demonstration of a high susceptibility for transcriptional repression of cell cycle genes in B lymphoblasts from a patient with Scott syndrome. BMC Genomics. 2005;6:146 pubmed
  42. Bucki R, Pastore J. Bacterial endotoxin as inhibitor of the enzymatic activity of human thrombin. Eur J Haematol. 2006;76:510-5 pubmed
    ..When added to platelet-rich plasma, after activation with collagen, LPS-inhibited thrombin activity. LPS-mediated inhibition of thrombin activity may contribute to the hemostasis dysfunctions observed during endotoxemia. ..
  43. Tempe D, Virmani S. Coagulation abnormalities in patients with cyanotic congenital heart disease. J Cardiothorac Vasc Anesth. 2002;16:752-65 pubmed
  44. Trammell R, Brooks M, Cox L, Ding M, Wagenknecht D, Rehg J, et al. Fatal hemorrhagic diathesis associated with mild factor IX deficiency in pl/J mice. Comp Med. 2006;56:426-34 pubmed
    ..PL/J mice could represent a new model for the study of pathogenesis and therapy of mild factor IX deficiency that is expressed and becomes clinically apparent secondary to major surgery. ..
  45. Lai Cheong J, Banerjee P, Hill V, Kenny P, Ross J. Bullous acute haemorrhagic oedema of skin in infancy. Clin Exp Dermatol. 2007;32:467-8 pubmed
  46. White J, Thomas A. Platelet structural pathology in a patient with the X-linked GATA-1, R216Q mutation. Platelets. 2009;20:41-9 pubmed publisher
  47. Khan M, Grinberg R, Johnson S, Afthinos J, Gibbs K. Perioperative risk factors for 30-day mortality after bariatric surgery: is functional status important?. Surg Endosc. 2013;27:1772-7 pubmed publisher
    ..Notably, baseline functional status before surgery is the single most powerful predictor of perioperative survival and should be incorporated into risk stratification models. ..
  48. Nair S, Dargaud Y, Chitlur M, Srivastava A. Tests of global haemostasis and their applications in bleeding disorders. Haemophilia. 2010;16 Suppl 5:85-92 pubmed publisher
    ..Furthermore, these tests need to be standardized with regard to their reagents, methodology and interpretation, and finally, much more data need to be collected regarding clinical correlations with the parameters measured. ..
  49. De Jager E, Bieger R, Castel A, Kluin P. Successful treatment of an acquired haemorrhagic diathesis due to factor X deficiency with chemotherapy. Eur J Haematol. 2001;66:352-4 pubmed
    ..Treatment with intermittent chemotherapy, consisting of vincristine, cytoxan and prednisone, yielded definite clinical and laboratory improvement...
  50. Venkateswaran L, Yee D. Rare bleeding disorders in young women. J Pediatr Adolesc Gynecol. 2010;23:S38-42 pubmed publisher
    ..This review provides an overview of these infrequently encountered disorders, discusses their recognition based on results of suggested screening tests and offers a general guideline for approach to therapy...
  51. Amer A, Amer M. Enhanced monocyte tissue factor expression in hepatosplenic schistosomiasis. Blood Coagul Fibrinolysis. 2002;13:43-7 pubmed
    ..These findings constitute further evidence for an existing prothrombotic state in hepatosplenic Schistosomiasis, and also that monocytes are closely implicated in the haemostatic diathesis characterizing the disease...
  52. Mascitelli L, Pezzetta F. Cardiovascular protections in severely impaired hemostasis. Circulation. 2004;110:e39 pubmed
  53. Horikawa N. [Consultation-liaison psychiatry]. Seishin Shinkeigaku Zasshi. 2007;109:709-11 pubmed
  54. Howard J, Diaz M, Soler M. Hemorrhagic shock resulting from post-coital vaginal bleeding in an adolescent with Ehlers-Danlos type IV. Pediatr Emerg Care. 2009;25:397-8 pubmed publisher
    ..We present a novel case of a 16-year-old female with vascular Ehlers-Danlos syndrome (formerly Ehlers-Danlos type IV) who was brought to the emergency department with brisk vaginal bleeding after her first episode of sexual intercourse...
  55. Rodeghiero F, Tosetto A, Abshire T, Arnold D, Coller B, James P, et al. ISTH/SSC bleeding assessment tool: a standardized questionnaire and a proposal for a new bleeding score for inherited bleeding disorders. J Thromb Haemost. 2010;8:2063-5 pubmed publisher
  56. Takahashi R, Ono K, Ikeda T, Akagi A, Noto D, Nozaki I, et al. Coagulation and fibrinolysis abnormalities in familial amyloid polyneuropathy. Amyloid. 2012;19:129-32 pubmed publisher
    ..However, few have investigated coagulation and fibrinolysis in FAP. The objective of this study was to determine abnormalities in plasma biomarkers of coagulation and fibrinolysis in FAP...
  57. Armas Loughran B, Kalra R, Carson J. Evaluation and management of anemia and bleeding disorders in surgical patients. Med Clin North Am. 2003;87:229-42 pubmed
    ..Finally, some patients may need correction of their bleeding disorder before surgery or careful monitoring in the perioperative period...
  58. Dobreva D. [Plant preparations of Sofarma in gynecological practice]. Akush Ginekol (Sofiia). 2003;42 Suppl 1:24-5 pubmed
  59. Bax N, van der Zee D. The laparoscopic approach to sacrococcygeal teratomas. Surg Endosc. 2004;18:128-30 pubmed
    ..A laparotomy is also added when the tumor extends presacrally into the pelvis. The presacral region is, however, difficult to access. A laparoscopic-assisted approach seems to offer a solution for both problems...
  60. Vassilopoulos P, Palcanis K. Bleeding disorders and periodontology. Periodontol 2000. 2007;44:211-23 pubmed
  61. Byams V. Women with bleeding disorders. J Womens Health (Larchmt). 2007;16:1249-51 pubmed
    ..S., and determine the best treatment options...
  62. Robson P, Mumford A. Familial multiple coagulation factor deficiencies - chance associations and distinct clinical disorders. Haemophilia. 2009;15:11-9 pubmed publisher
    ..This review summarizes the historical literature that describes the FMCFDs and introduces a refined classification of these disorders. The clinical and laboratory characteristics of the most common FMCFDs are considered in detail...
  63. Peyvandi F, Bidlingmaier C, Garagiola I. Management of pregnancy and delivery in women with inherited bleeding disorders. Semin Fetal Neonatal Med. 2011;16:311-7 pubmed publisher
    ..A multidisciplinary team of obstetricians, haematologists and paediatricians is required with a good knowledge of these disorders and an awareness of the potential maternal neonatal complications...
  64. Ruiz Saez A. Thrombosis in rare bleeding disorders. Hematology. 2012;17 Suppl 1:S156-8 pubmed publisher
    ..In patients with history of thrombosis it may be helpful to perform a thrombophilia screening to exclude coexisting prothrombotic defects and for all patients it is recommended to control known cardiovascular disease risk factors...
  65. Hattori K, Yabe M, Matsumoto M, Kudo Y, Yasuda Y, Inoue H, et al. Successful hyperbaric oxygen treatment of life-threatening hemorrhagic cystitis after allogeneic bone marrow transplantation. Bone Marrow Transplant. 2001;27:1315-7 pubmed
    ..We report two cases of life-threatening late-onset HC after allogeneic BMT in children, which resolved after treatment with hyperbaric oxygen...
  66. Fujimura Y, Matsumoto M, Yagi H, Yoshioka A, Matsui T, Titani K. Von Willebrand factor-cleaving protease and Upshaw-Schulman syndrome. Int J Hematol. 2002;75:25-34 pubmed
  67. Piot B, Sigaud Fiks M, Huet P, Fressinaud E, Trossaert M, Mercier J. Management of dental extractions in patients with bleeding disorders. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;93:247-50 pubmed
    ..This study evaluated the effectiveness of a protocol to prevent bleeding after dental extraction in patients with hemophilia, von Willebrand's disease (VWD), or platelet disorders...
  68. Del Vecchio A. Use of the bleeding time in the neonatal intensive care unit. Acta Paediatr Suppl. 2002;91:82-6 pubmed
  69. McVey J. Your bleeding heart: lessons from low tissue factor expression in mice. Trends Pharmacol Sci. 2003;24:269-72 pubmed
    ..In addition, the study indicates that the heart is subject to a succession of minor bleeds most probably as a result of repetitive minor mechanical injury to the blood vessels...
  70. Girolami A, Ruzzon E, Tezza F, Allemand E, Vettore S. Congenital combined defects of factor VII: a critical review. Acta Haematol. 2007;117:51-6 pubmed
    ..Finally, the elevated incidence of mental and skeletal malformations present in these combined defects indicates the need for a careful evaluation of all these patients lest some aspects of the defect are missed...
  71. Mohamed M, Ashikov A, Guillard M, Robben J, Schmidt S, van den Heuvel B, et al. Intellectual disability and bleeding diathesis due to deficient CMP--sialic acid transport. Neurology. 2013;81:681-7 pubmed publisher
    ..To identify the underlying genetic defect in a patient with intellectual disability, seizures, ataxia, macrothrombocytopenia, renal and cardiac involvement, and abnormal protein glycosylation...
  72. Lalloo D, Trevett A, Owens D, Minei J, Naraqi S, Saweri A, et al. Coagulopathy following bites by the Papuan taipan (Oxyuranus scutellatus canni). Blood Coagul Fibrinolysis. 1995;6:65-72 pubmed
    ..These abnormalities may be primarily attributable to the prothrombin activator present in taipan venom, but it is likely that other uncharacterized venom components contributed...
  73. Sheu J, Lee C, Lin C, Hsiao G, Ko W, Chen Y, et al. Mechanisms involved in the antiplatelet activity of Staphylococcus aureus lipoteichoic acid in human platelets. Thromb Haemost. 2000;83:777-84 pubmed
    ..Therefore, LTA-mediated alteration of platelet function may contribute to bleeding diathesis in gram-positive septicemic and endotoxemic patients...
  74. Girolami A, Luzzatto G, Varvarikis C, Pellati D, Sartori R, Girolami B. Main clinical manifestations of a bleeding diathesis: an often disregarded aspect of medical and surgical history taking. Haemophilia. 2005;11:193-202 pubmed
    ..g. a platelet count for petechiae, a PTT for a patient with haemarthrosis, etc.)...
  75. Duckers C, Simioni P, Spiezia L, Radu C, Gavasso S, Rosing J, et al. Low plasma levels of tissue factor pathway inhibitor in patients with congenital factor V deficiency. Blood. 2008;112:3615-23 pubmed publisher
    ..Low TFPI levels decreased the FV requirement for minimal thrombin generation in FV-deficient plasma to less than 1% and might therefore protect FV-deficient patients from severe bleeding...
  76. Englbrecht J, Pogatzki Zahn E, Zahn P. [Spinal and epidural anesthesia in patients with hemorrhagic diathesis : decisions on the brink of minimum evidence?]. Anaesthesist. 2011;60:1126-34 pubmed publisher
    ..This overview is intended to assist in the decision for or against neuraxial anesthesia in these patients, with emphasis on the pathophysiological background, blood investigations and case reports from the literature...
  77. Patel P, Arambula A, Wheeler A, Penn E. Post-tonsillectomy hemorrhagic outcomes in children with bleeding disorders at a single institution. Int J Pediatr Otorhinolaryngol. 2017;100:216-222 pubmed publisher
    ..This risk appears to decrease with the use of an institutional protocol consisting of desmopressin or factor replacement and an antifibrinolytic agent extending through postoperative day 10. ..
  78. Bertola D, Carneiro J, D Amico E, Kim C, Albano L, Sugayama S, et al. Hematological findings in Noonan syndrome. Rev Hosp Clin Fac Med Sao Paulo. 2003;58:5-8 pubmed
    ..The purpose of this study was to determine the frequency of hemostatic abnormalities in a group of Noonan syndrome patients...
  79. Marx P. Thrombin-activatable fibrinolysis inhibitor. Curr Med Chem. 2004;11:2335-48 pubmed
    ..Moreover, TAFI may also play a role in other processes such as, inflammation and tissue repair. In this review, recent developments in TAFI research are discussed...
  80. Vaynshtein G, Rosenbaum H, Groisman G, Markel A. Celiac sprue presenting as severe hemorrhagic diathesis due to vitamin K deficiency. Isr Med Assoc J. 2004;6:781-3 pubmed
  81. Packham M, Mustard J. Platelet aggregation and adenosine diphosphate/adenosine triphosphate receptors: a historical perspective. Semin Thromb Hemost. 2005;31:129-38 pubmed
    ..ATP stimulates a rapid influx of calcium into platelets through the P2X (1) receptor, and it may synergize with ADP when these two nucleotides are released from platelets at a site of vessel injury...
  82. Guibert Bayona M, Borque Martín J, Araújo Fernández A, Ruiz Ilundain G. [Anesthesia in May-Hegglin anomaly]. Rev Esp Anestesiol Reanim. 2006;53:583-4 pubmed
  83. Branchford B, Monahan P, Di Paola J. New developments in the treatment of pediatric hemophilia and bleeding disorders. Curr Opin Pediatr. 2013;25:23-30 pubmed publisher
    ..Because of the limitations of current treatment options, novel therapies are being developed, many of which are reviewed here...
  84. Spena S, Duga S, Asselta R, Malcovati M, Peyvandi F, Tenchini M. Congenital afibrinogenemia: first identification of splicing mutations in the fibrinogen Bbeta-chain gene causing activation of cryptic splice sites. Blood. 2002;100:4478-84 pubmed
    ..Both mutations are predicted to determine protein truncations, supporting the importance of the C-terminal domain of the Bbeta chain for fibrinogen assembly and secretion...
  85. Stammler F. [Haemorrhagic diathesis as an early symptom of systemic amyloidosis]. Dtsch Med Wochenschr. 2006;131:17-21 pubmed
    ..He also had signs of heart failure with progressive exertional dyspnoea. Many months previously numerous bleedings had occurred in the skin, predominantly the face (periorbital and perioral), the inguinal region and the penis...
  86. Koller E, Wei X, Johnson T. Oxandrolone steroid use and impaired coagulation. Arch Intern Med. 2006;166:125 pubmed
  87. Pinto A, Berger M, Reck J, Terra R, Guimaraes J. Lonomia obliqua venom: In vivo effects and molecular aspects associated with the hemorrhagic syndrome. Toxicon. 2010;56:1103-12 pubmed publisher
    ..Herein studies from several authors which characterized the complex toxic-pharmacological actions of whole venom are reviewed...
  88. Brunner F, Tomandl B, Schroter A, Mellinghoff C, Haldenwanger A, Hildebrandt H, et al. Hemorrhagic complications after systemic thrombolysis in acute stroke patients with abnormal baseline coagulation. Eur J Neurol. 2011;18:1407-11 pubmed publisher
    ..As patients with abnormal baseline coagulation were excluded from the large randomized trials, the safety of intravenous thrombolysis after ischaemic stroke in this patient population remains controversial...
  89. Tsubokawa T, Joshita H, Shiokawa Y, Miyazaki H. Hyperglycemia and hemorrhagic transformation of cerebral infarction: a macroscopic hemorrhagic transformation rat model. Acta Neurochir Suppl. 2011;111:43-8 pubmed publisher
  90. Ruiz A, Borum M. Cytomegalovirus hemorrhagic gastritis. AIDS Patient Care STDS. 2001;15:1-5 pubmed
    ..Characteristic findings on upper endoscopy are punched-out gastric ulcers. This is a rare case of CMV disease of the stomach presenting as hemorrhagic, necrotic gastritis with inflammatory bridging...
  91. Hayashi K, Matsuda H, Honda M, Ozawa Y, Tokuyama H, Okubo K, et al. Impact of calcium antagonists on bleeding time in patients with chronic renal failure. J Hum Hypertens. 2002;16:199-203 pubmed
    ..The subclinical (laboratory) effect of calcium antagonists however is not necessarily associated with haemorrhagic events of clinical significance...
  92. Maino A, Garagiola I, Artoni A, Al Humood S, Peyvandi F. A novel mutation of alpha2-plasmin inhibitor gene causes an inherited deficiency and a bleeding tendency. Haemophilia. 2008;14:166 pubmed