thrombocytosis

Summary

Summary: Increased numbers of platelets in the peripheral blood. (Dorland, 27th ed)

Top Publications

  1. Carobbio A, Finazzi G, Antonioli E, Guglielmelli P, Vannucchi A, Delaini F, et al. Thrombocytosis and leukocytosis interaction in vascular complications of essential thrombocythemia. Blood. 2008;112:3135-7 pubmed publisher
    To elucidate the role of thrombocytosis, alone or in combination with standard (age, previous cardiovascular events) and novel (leukocytosis, JAK2(V617F) mutational status) risk factors, in the cardiovascular events of essential ..
  2. Gattermann N, Billiet J, Kronenwett R, Zipperer E, Germing U, Nollet F, et al. High frequency of the JAK2 V617F mutation in patients with thrombocytosis (platelet count>600x109/L) and ringed sideroblasts more than 15% considered as MDS/MPD, unclassifiable. Blood. 2007;109:1334-5 pubmed
  3. Schmitt Graeff A, Teo S, Olschewski M, Schaub F, Haxelmans S, Kirn A, et al. JAK2V617F mutation status identifies subtypes of refractory anemia with ringed sideroblasts associated with marked thrombocytosis. Haematologica. 2008;93:34-40 pubmed publisher
    Refractory anemia with ringed sideroblasts and marked thrombocytosis (RARS-T) was recently shown to be a JAK2-V617F mutation-related disorder...
  4. El Harith E, Roesl C, Ballmaier M, Germeshausen M, Frye Boukhriss H, von Neuhoff N, et al. Familial thrombocytosis caused by the novel germ-line mutation p.Pro106Leu in the MPL gene. Br J Haematol. 2009;144:185-94 pubmed publisher
    ..We studied an Arab family with two siblings with severe thrombocytosis by linkage analysis and obtained evidence for linkage to MPL...
  5. Costello F, Zimmerman M, Podhajsky P, Hayreh S. Role of thrombocytosis in diagnosis of giant cell arteritis and differentiation of arteritic from non-arteritic anterior ischemic optic neuropathy. Eur J Ophthalmol. 2004;14:245-57 pubmed
    To investigate the role of thrombocytosis in the diagnosis of giant cell arteritis (GCA), and differentiation of arteritic (A-AION) from non-arteritic (NA-AION) anterior ischemic optic neuropathy; and comparison of the sensitivity and ..
  6. Lannutti B, Minear J, Blake N, Drachman J. Increased megakaryocytopoiesis in Lyn-deficient mice. Oncogene. 2006;25:3316-24 pubmed
    ..This is the first direct evidence using primary MKs from Lyn-deficient mice that confirms our prior data from cell lines that Lyn kinase is a negative regulator of TPO signaling. ..
  7. Pikman Y, Lee B, Mercher T, McDowell E, Ebert B, Gozo M, et al. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med. 2006;3:e270 pubmed
    The JAK2V617F allele has recently been identified in patients with polycythemia vera (PV), essential thrombocytosis (ET), and myelofibrosis with myeloid metaplasia (MF)...
  8. Huls G, Mulder A, Rosati S, van de Loosdrecht A, Vellenga E, de Wolf J. Efficacy of single-agent lenalidomide in patients with JAK2 (V617F) mutated refractory anemia with ring sideroblasts and thrombocytosis. Blood. 2010;116:180-2 pubmed publisher
    Patients with refractory anemia with ring sideroblasts and thrombocytosis (RARS-T) are difficult to treat because the cytoreductive treatment might be beneficial for the thrombocytosis component but harmful for the RARS component...
  9. Spivak J. Narrative review: Thrombocytosis, polycythemia vera, and JAK2 mutations: The phenotypic mimicry of chronic myeloproliferation. Ann Intern Med. 2010;152:300-6 pubmed publisher
    The myeloproliferative disorders polycythemia vera, essential thrombocytosis, and primary myelofibrosis are clonal disorders arising in a pluripotent hematopoietic stem cell, causing an unregulated increase in the number of erythrocytes, ..

More Information

Publications62

  1. Szpurka H, Tiu R, Murugesan G, Aboudola S, Hsi E, Theil K, et al. Refractory anemia with ringed sideroblasts associated with marked thrombocytosis (RARS-T), another myeloproliferative condition characterized by JAK2 V617F mutation. Blood. 2006;108:2173-81 pubmed
    ..features consistent with the provisional MDS/MPD-U entity refractory anemia with ringed sideroblasts and thrombocytosis (RARS-T)...
  2. Atallah E, Nussenzveig R, Yin C, Bueso Ramos C, Tam C, Manshouri T, et al. Prognostic interaction between thrombocytosis and JAK2 V617F mutation in the WHO subcategories of myelodysplastic/myeloproliferative disease-unclassifiable and refractory anemia with ringed sideroblasts and marked thrombocytosis. Leukemia. 2008;22:1295-8 pubmed
  3. Chow D, Sung J, Tsoi K, Wong V, Wu J, Leong R, et al. Predictors of corticosteroid-dependent and corticosteroid-refractory inflammatory bowel disease: analysis of a Chinese cohort study. Aliment Pharmacol Ther. 2009;29:843-54 pubmed publisher
    ..Seventy-seven (57.5%) CD and 95 (54.0%) UC patients had received corticosteroids during study period. In CD, thrombocytosis [Hazard ratio (HR):3.0] predicted, whereas colonic CD (HR:0.3) negatively predicted corticosteroid dependency...
  4. Raya J, Arenillas L, Domingo A, Bellosillo B, Gutierrez G, Luño E, et al. Refractory anemia with ringed sideroblasts associated with thrombocytosis: comparative analysis of marked with non-marked thrombocytosis, and relationship with JAK2 V617F mutational status. Int J Hematol. 2008;88:387-395 pubmed publisher
    ..2001) defined a provisional entity named refractory anemia with ringed sideroblasts associated to marked thrombocytosis (RARS-MT)...
  5. Standridge S, de los Reyes E. Inflammatory bowel disease and cerebrovascular arterial and venous thromboembolic events in 4 pediatric patients: a case series and review of the literature. J Child Neurol. 2008;23:59-66 pubmed publisher
    ..All of the patients had additional risk factors for thrombosis including thrombocytosis, severe dehydration attributable to an inflammatory bowel disease exacerbation, and, in 2 instances, ..
  6. Streja E, Kovesdy C, Greenland S, Kopple J, McAllister C, Nissenson A, et al. Erythropoietin, iron depletion, and relative thrombocytosis: a possible explanation for hemoglobin-survival paradox in hemodialysis. Am J Kidney Dis. 2008;52:727-36 pubmed publisher
    ..hemodialysis patients to examine the hypothesis that the induced iron depletion with resultant relative thrombocytosis may be a possible contributor to the link between the high rHuEPO dose-associated hemoglobin level of 13 g/dL ..
  7. Teofili L, Giona F, Torti L, Cenci T, Ricerca B, Rumi C, et al. Hereditary thrombocytosis caused by MPLSer505Asn is associated with a high thrombotic risk, splenomegaly and progression to bone marrow fibrosis. Haematologica. 2010;95:65-70 pubmed publisher
    ..search for this mutation to all patients with essential thrombocythemia who had a positive family history for thrombocytosis or essential thrombocythemia. We identified eight Italian families positive for the MPL(Ser505Asn) mutation...
  8. Koppikar P, Abdel Wahab O, Hedvat C, Marubayashi S, Patel J, Goel A, et al. Efficacy of the JAK2 inhibitor INCB16562 in a murine model of MPLW515L-induced thrombocytosis and myelofibrosis. Blood. 2010;115:2919-27 pubmed publisher
    ..However, we did not observe a decrease in the size of the malignant clone in the bone marrow of treated mice at the end of therapy, which suggests that JAK2 inhibitor therapy, by itself, was not curative in this MPN model. ..
  9. Qiu M, Xu R, Ruan D, Li Z, Luo H, Teng K, et al. Incidence of anemia, leukocytosis, and thrombocytosis in patients with solid tumors in China. Tumour Biol. 2010;31:633-41 pubmed publisher
    ..The percentages of leukocytosis, anemia, and thrombocytosis in patients with solid tumors ranged from 4.0% to 25.6%, 3.3% to 29.2%, and 2.1% to 9.7%, respectively...
  10. Kulnigg Dabsch S, Schmid W, Howaldt S, Stein J, Mickisch O, Waldhor T, et al. Iron deficiency generates secondary thrombocytosis and platelet activation in IBD: the randomized, controlled thromboVIT trial. Inflamm Bowel Dis. 2013;19:1609-16 pubmed publisher
    Secondary thrombocytosis is a common clinical feature. In patients with cancer, it is a risk factor for venous thromboembolic events...
  11. Thachil J. Extreme thrombocytosis--an unusual presentation of inflammatory bowel disease. Intern Med. 2008;47:1255-7 pubmed
    b>Thrombocytosis or a high platelet count (a count greater than 400 x 10(9)/L) is a common observation especially with the increased ordering of routine complete blood counts...
  12. Njølstad T, Engerud H, Werner H, Salvesen H, Trovik J. Preoperative anemia, leukocytosis and thrombocytosis identify aggressive endometrial carcinomas. Gynecol Oncol. 2013;131:410-5 pubmed publisher
    The objective of this study is to investigate preoperative hematological parameters for anemia, leukocytosis and thrombocytosis in relation to established prognostic factors and survival in endometrial cancer.
  13. Mirsaeidi M, Peyrani P, Aliberti S, Filardo G, Bordon J, Blasi F, et al. Thrombocytopenia and thrombocytosis at time of hospitalization predict mortality in patients with community-acquired pneumonia. Chest. 2010;137:416-20 pubmed publisher
    ..Abnormal platelet count was < 100,000/L (thrombocytopenia) and > 400,000/L (thrombocytosis). The outcome variable was 30-day mortality...
  14. Schnittger S, Bacher U, Haferlach C, Dengler R, Krober A, Kern W, et al. Detection of an MPLW515 mutation in a case with features of both essential thrombocythemia and refractory anemia with ringed sideroblasts and thrombocytosis. Leukemia. 2008;22:453-5 pubmed
  15. Pemmaraju N, Moliterno A, Williams D, Rogers O, Spivak J. The quantitative JAK2 V617F neutrophil allele burden does not correlate with thrombotic risk in essential thrombocytosis. Leukemia. 2007;21:2210-2 pubmed
  16. Wang S, Hasserjian R, Loew J, Sechman E, Jones D, Hao S, et al. Refractory anemia with ringed sideroblasts associated with marked thrombocytosis harbors JAK2 mutation and shows overlapping myeloproliferative and myelodysplastic features. Leukemia. 2006;20:1641-4 pubmed
  17. Samuelsson J, Hasselbalch H, Bruserud O, Temerinac S, Brandberg Y, Merup M, et al. A phase II trial of pegylated interferon alpha-2b therapy for polycythemia vera and essential thrombocythemia: feasibility, clinical and biologic effects, and impact on quality of life. Cancer. 2006;106:2397-405 pubmed
    ..The reversal of PRV-1 positivity noted in a subset of patients suggested that PEG-IFN may have an effect on the malignant clone. PEG-IFN is a valuable therapeutic alternative for patients who tolerate its initial side effects. ..
  18. Okon A, Dubinsky M, Vasiliauskas E, Papadakis K, Ippoliti A, Targan S, et al. Elevated platelet count before ileal pouch-anal anastomosis for ulcerative colitis is associated with the development of chronic pouchitis. Am Surg. 2005;71:821-6 pubmed
    ..Reactive thrombocytosis (RT) was defined as a platelet count > 450 x 10(9)/L...
  19. Stein B, Williams D, O Keefe C, Rogers O, Ingersoll R, Spivak J, et al. Disruption of the ASXL1 gene is frequent in primary, post-essential thrombocytosis and post-polycythemia vera myelofibrosis, but not essential thrombocytosis or polycythemia vera: analysis of molecular genetics and clinical phenotypes. Haematologica. 2011;96:1462-9 pubmed publisher
    The myeloproliferative neoplasms, essential thrombocytosis, polycythemia vera and primary myelofibrosis, share the same acquired genetic lesion, but the concept of JAK2 V617F serving as the sole lesion responsible for these neoplasms is ..
  20. Malcovati L, Della Porta M, Pietra D, Boveri E, Pellagatti A, Galli A, et al. Molecular and clinical features of refractory anemia with ringed sideroblasts associated with marked thrombocytosis. Blood. 2009;114:3538-45 pubmed publisher
    We studied patients with myeloid neoplasm associated with ringed sideroblasts and/or thrombocytosis. The combination of ringed sideroblasts 15% or greater and platelet count of 450 x 10(9)/L or greater was found in 19 subjects fulfilling ..
  21. Lannutti B, Epp A, Roy J, Chen J, Josephson N. Incomplete restoration of Mpl expression in the mpl-/- mouse produces partial correction of the stem cell-repopulating defect and paradoxical thrombocytosis. Blood. 2009;113:1778-85 pubmed publisher
    ..Transgene rescued mice exhibit thrombocytosis but only partial correction of the stem cell defect...
  22. Prchal J. Classification and molecular biology of polycythemias (erythrocytoses) and thrombocytosis. Hematol Oncol Clin North Am. 2003;17:1151-8, vi pubmed
    ..The central premise of this article is that deciphering the molecular basis of human diseases leads to improved understanding of hematopoiesis, precise diagnosis, and the potential for development of a specific therapy...
  23. Murphy A, Bijl N, Yvan Charvet L, Welch C, Bhagwat N, Reheman A, et al. Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis. Nat Med. 2013;19:586-94 pubmed publisher
    ..of bone marrow deficient in ABCG4, a transporter of unknown function, into Ldlr(-/-) mice resulted in thrombocytosis, accelerated thrombosis and atherosclerosis...
  24. Shinnick K, Eklund E, McGarry T. Geminin deletion from hematopoietic cells causes anemia and thrombocytosis in mice. J Clin Invest. 2010;120:4303-15 pubmed publisher
    ..These data led us to postulate that Geminin regulates the relative production of erythrocytes and megakaryocytes from megakaryocyte-erythrocyte precursors by a replication-independent mechanism. ..
  25. Flach J, Dicker F, Schnittger S, Kohlmann A, Haferlach T, Haferlach C. Mutations of JAK2 and TET2, but not CBL are detectable in a high portion of patients with refractory anemia with ring sideroblasts and thrombocytosis. Haematologica. 2010;95:518-9 pubmed publisher
  26. Besarab A, Hörl W, Silverberg D. Iron metabolism, iron deficiency, thrombocytosis, and the cardiorenal anemia syndrome. Oncologist. 2009;14 Suppl 1:22-33 pubmed publisher
    ..v. iron showed evidence of nephrotoxicity caused by i.v. iron. Iron deficiency is a risk factor for thrombocytosis and should, wherever possible, be avoided...
  27. Stone R, Nick A, McNeish I, Balkwill F, Han H, Bottsford Miller J, et al. Paraneoplastic thrombocytosis in ovarian cancer. N Engl J Med. 2012;366:610-8 pubmed publisher
    The mechanisms of paraneoplastic thrombocytosis in ovarian cancer and the role that platelets play in abetting cancer growth are unclear...
  28. Holgersson G, Sandelin M, Hoye E, Bergström S, Henriksson R, Ekman S, et al. Swedish lung cancer radiation study group: the prognostic value of anaemia, thrombocytosis and leukocytosis at time of diagnosis in patients with non-small cell lung cancer. Med Oncol. 2012;29:3176-82 pubmed publisher
    ..These results indicate that standard haematological variables may be used as guidance for the clinician in the decision-making regarding treatment intensity and patient information...
  29. Tiedt R, Coers J, Ziegler S, Wiestner A, Hao Shen H, Bornmann C, et al. Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes. Blood. 2009;113:1768-77 pubmed publisher
    ..These mice developed thrombocytosis with platelet levels approximately 5-fold higher than wild-type controls and markedly increased megakaryocyte ..
  30. Ceresa I, Noris P, Ambaglio C, Pecci A, Balduini C. Thrombopoietin is not uniquely responsible for thrombocytosis in inflammatory disorders. Platelets. 2007;18:579-82 pubmed
    A few studies in patients with reactive thrombocytosis identified levels of the hormone higher than expected, and suggested that TPO behaves as an acute-phase protein and was responsible for increased platelet count...
  31. Wheler J, Tsimberidou A, Hong D, Naing A, Jackson T, Liu S, et al. Survival of patients in a Phase 1 Clinic: the M. D. Anderson Cancer Center experience. Cancer. 2009;115:1091-9 pubmed publisher
    ..09; P = .013). Patients who were referred to phase 1 studies had a short median survival (9 months). Patients with thrombocytosis, liver metastases, and a history of thromboembolism had worse outcomes. A prognostic score is proposed.
  32. Voudoukis E, Karmiris K, Oustamanolakis P, Theodoropoulou A, Sfiridaki A, Paspatis G, et al. Association between thrombocytosis and iron deficiency anemia in inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2013;25:1212-6 pubmed publisher
    b>Thrombocytosis and iron deficiency anemia are frequent complications of inflammatory bowel disease (IBD). The aim of this study was to investigate the correlation between iron deficiency anemia and thrombocytosis in IBD patients...
  33. Cunha B, Pherez F. Mycoplasma pneumoniae community-acquired pneumonia (CAP) in the elderly: Diagnostic significance of acute thrombocytosis. Heart Lung. 2009;38:444-9 pubmed publisher
    ..It is a common misconception that acute thrombocytosis is an acute phase reactant. Her acute thrombocytosis increased and persisted...
  34. Wysoczynski M, Kucia M, Ratajczak J, Ratajczak M. Cleavage fragments of the third complement component (C3) enhance stromal derived factor-1 (SDF-1)-mediated platelet production during reactive postbleeding thrombocytosis. Leukemia. 2007;21:973-82 pubmed
    ..component (C3) cleavage fragments (C3a and (des-Arg)C3a) are involved in stress/inflammation-related thrombocytosis, and investigated their potential role in reactive thrombocytosis induced by bleeding...
  35. Yadav D, Chandra J, Sharma S, Singh V. Clinicohematological study of thrombocytosis. Indian J Pediatr. 2010;77:643-7 pubmed publisher
    To find out etiology and clinical course of thrombocytosis in Indian pediatric population...
  36. Zhang L, Lukowski R, Gaertner F, Lorenz M, Legate K, Domes K, et al. Thrombocytosis as a response to high interleukin-6 levels in cGMP-dependent protein kinase I mutant mice. Arterioscler Thromb Vasc Biol. 2013;33:1820-8 pubmed publisher
    ..b>Thrombocytosis was detected in cGKI(L1/L1) and in cGKI-SM...
  37. Firmin D, Roguedas A, LeMasson G, Abgrall J, Misery L. Eczematous dermatosis and thrombocytosis induced by efalizumab: two new side effects. Dermatology. 2008;217:203-6 pubmed publisher
    ..We report 2 adverse events under efalizumab that to our knowledge have never been described: a case of an eczematous rash and a case of thrombocytosis.
  38. Basak R, Chowdhury A, Fatmi L, Saha N, Mollah A, Yasmin S. Stroke in the young: relationship with iron deficiency anemia and thrombocytosis. Mymensingh Med J. 2008;17:74-7 pubmed
    ..Complete blood count and iron profile evaluated iron deficiency anemia with thrombocytosis. Thrombosis resulting from thrombocytosis secondary to iron deficiency anemia was considered as etiological ..
  39. González Villalva A, Fortoul T, Avila Costa M, Piñón Zarate G, Rodriguez Laraa V, Martínez Levy G, et al. Thrombocytosis induced in mice after subacute and subchronic V2O5 inhalation. Toxicol Ind Health. 2006;22:113-6 pubmed
    ..Our results demonstrate, for the first time, that V induces thrombocytosis and it might correlate with some thromboembolic diseases...
  40. Biino G, Balduini C, Casula L, Cavallo P, Vaccargiu S, Parracciani D, et al. Analysis of 12,517 inhabitants of a Sardinian geographic isolate reveals that predispositions to thrombocytopenia and thrombocytosis are inherited traits. Haematologica. 2011;96:96-101 pubmed publisher
    ..5% to 6.8%, and was negatively correlated with the prevalence of a mild form of thrombocytosis, which ranged from 0.9% to 4.5%...
  41. Yan X, Lacey D, Fletcher F, Hartley C, McElroy P, Sun Y, et al. Chronic exposure to retroviral vector encoded MGDF (mpl-ligand) induces lineage-specific growth and differentiation of megakaryocytes in mice. Blood. 1995;86:4025-33 pubmed
    ..No significant effect on other hematopoietic lineages was seen in the MGDF overexpressing mice, showing that the stimulatory effect of MGDF in vivo is restricted to the megakaryocyte lineage. ..
  42. Klinger M, Jelkmann W. Role of blood platelets in infection and inflammation. J Interferon Cytokine Res. 2002;22:913-22 pubmed
    ..In contrast, chronic inflammation is often associated with reactive thrombocytosis. Platelets can bind and internalize pathogens and release microbicidal proteins that kill certain bacteria and ..
  43. Fukasawa H, Furuya R, Kato A, Yonemura K, Fujigaki Y, Yamamoto T, et al. Pseudohyperkalemia occurring in a patient with chronic renal failure and polycythemia vera without severe leukocytosis or thrombocytosis. Clin Nephrol. 2002;58:451-4 pubmed
    ..leukocytes, or erythrocytes, commonly in the setting of extreme leukocytosis (> 10 x 10(4)/microl) or thrombocytosis (> 60 x 10(4)/microl)...
  44. Thiele J, Kvasnicka H, Fuchs N, Brunnbauer K, Volkwein N, Schmitt Graeff A. Anagrelide-induced bone marrow changes during therapy of chronic myeloproliferative disorders with thrombocytosis. an immunohistochemical and morphometric study of sequential trephine biopsies. Haematologica. 2003;88:1130-8 pubmed
    ..These patients received anagrelide for 25 months resulting in a significant improvement of thrombocytosis. Evaluations were carried out by morphometry on sequential BM biopsies following enzyme- and ..
  45. Schafer A. Thrombocytosis and thrombocythemia. Blood Rev. 2001;15:159-66 pubmed
    b>Thrombocytosis is caused by three major pathophysiological mechanisms: (1) reactive or secondary thrombocytosis; (2) familial thrombocytosis; and (3) clonal thrombocytosis, including essential thrombocythemia and related ..
  46. Chanet V, Tournilhac O, Dieu Bellamy V, Boiret N, Spitz P, Baud O, et al. Isolated spleen agenesis: a rare cause of thrombocytosis mimicking essential thrombocythemia. Haematologica. 2000;85:1211-3 pubmed
    b>Thrombocytosis is a common feature of myeloproliferative disorders but may also result from various conditions including chronic iron deficiency, hemorrhage, chronic inflammation and splenectomy...
  47. Inokuchi K, Dan K, Takatori M, Takahuji H, Uchida N, Inami M, et al. Myeloproliferative disease in transgenic mice expressing P230 Bcr/Abl: longer disease latency, thrombocytosis, and mild leukocytosis. Blood. 2003;102:320-3 pubmed
    ..Two founder mice exhibited mild granulocytosis and marked thrombocytosis and developed MPD. The disease of one founder mouse, no...
  48. Shimada H, Oohira G, Okazumi S, Matsubara H, Nabeya Y, Hayashi H, et al. Thrombocytosis associated with poor prognosis in patients with esophageal carcinoma. J Am Coll Surg. 2004;198:737-41 pubmed
    b>Thrombocytosis in patients with cancer has been reported to be associated with increased expression of angiogenic factors and with a poor prognosis in some types of cancer...
  49. Kralovics R, Passamonti F, Buser A, Teo S, Tiedt R, Passweg J, et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med. 2005;352:1779-90 pubmed
    ..A high proportion of patients with myeloproliferative disorders carry a dominant gain-of-function mutation of JAK2. ..
  50. Shih L, Lin T, Lai C, Dunn P, Wu J, Wang P, et al. Predictive values of X-chromosome inactivation patterns and clinicohematologic parameters for vascular complications in female patients with essential thrombocythemia. Blood. 2002;100:1596-601 pubmed
    ..083) and hypertension (P =.073) tended to predict thrombosis. Our results suggest that older patients who have clonal XCIPs or hypertension are at increased risk for thrombosis and should be monitored closely for this complication. ..
  51. Werynska B, Ramlau R, Podolak Dawidziak M, Jankowska R, Prajs I, Usnarska Zubkiewicz L, et al. Serum thrombopoietin levels in patients with reactive thrombocytosis due to lung cancer and in patients with essential thrombocythemia. Neoplasma. 2003;50:447-51 pubmed
    In patients with thrombocytosis normal to increased serum thrombopoietin (TPO) levels have been reported...
  52. Hefler L, Mayerhofer K, Leibman B, Obermair A, Reinthaller A, Kainz C, et al. Tumor anemia and thrombocytosis in patients with vulvar cancer. Tumour Biol. 2000;21:309-14 pubmed
    The aim of our study was to determine the prevalence of tumor anemia and thrombocytosis in patients with vulvar cancer, and to evaluate the prognostic value or pretreatment hemoglobin (Hb) and platelet count regarding disease-free and ..
  53. Shaw G. Ringed sideroblasts with thrombocytosis: an uncommon mixed myelodysplastic/myeloproliferative disease of older adults. Br J Haematol. 2005;131:180-4 pubmed
    Sideroblastic anaemia with ringed sideroblasts and marked thrombocytosis, hereupon referred to as ringed sideroblasts with thrombocytosis (RST), is a provisional entity in the 2001 World Health Organisation classification scheme...