thrombocytopenia

Summary

Summary: A subnormal level of BLOOD PLATELETS.

Top Publications

  1. YU X, Liang M, Zhang S, Liu Y, Li J, Sun Y, et al. Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med. 2011;364:1523-32 pubmed publisher
    ..of acute febrile illness in China since 2009 has led to the identification of a severe fever with thrombocytopenia syndrome (SFTS) with an unknown cause...
  2. Lambert M, Xiao L, Nguyen Y, Kowalska M, Poncz M. The role of platelet factor 4 in radiation-induced thrombocytopenia. Int J Radiat Oncol Biol Phys. 2011;80:1533-40 pubmed publisher
    Factors affecting the severity of radiation-induced thrombocytopenia (RIT) are not well described. We address whether platelet factor 4 (PF4; a negative paracrine for megakaryopoiesis) affects platelet recovery postradiation...
  3. Balduini C, Savoia A. Genetics of familial forms of thrombocytopenia. Hum Genet. 2012;131:1821-32 pubmed publisher
    ..In this review, we provide a systematic description of hereditary thrombocytopenias as we know them today, giving special attention to genetic aspects...
  4. Ali A, Bluteau O, Messaoudi K, Palazzo A, Boukour S, Lordier L, et al. Thrombocytopenia induced by the histone deacetylase inhibitor abexinostat involves p53-dependent and -independent mechanisms. Cell Death Dis. 2013;4:e738 pubmed publisher
    ..Like other HDACi, this drug induces a profound thrombocytopenia whose mechanism is only partially understood...
  5. Ikuta S, Tanimura K, Yasui C, Aihara T, Yoshie H, Iida H, et al. Chronic liver disease increases the risk of linezolid-related thrombocytopenia in methicillin-resistant Staphylococcus aureus-infected patients after digestive surgery. J Infect Chemother. 2011;17:388-91 pubmed publisher
    ..However, thrombocytopenia has been reported in a certain proportion of patients receiving linezolid treatment...
  6. Liang S, Bao C, Zhou M, Hu J, Tang F, Guo X, et al. Seroprevalence and risk factors for severe fever with thrombocytopenia syndrome virus infection in Jiangsu Province, China, 2011. Am J Trop Med Hyg. 2014;90:256-9 pubmed publisher
    Severe fever with thrombocytopenia syndrome (SFTS), which is caused by a novel bunyavirus, is an emerging infectious disease in China. In 2011, this new virus was designated as severe fever with thrombocytopenia syndrome virus (SFTSV)...
  7. Hirata S, Takayama N, Jono Ohnishi R, Endo H, Nakamura S, Dohda T, et al. Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling. J Clin Invest. 2013;123:3802-14 pubmed publisher
    Congenital amegakaryocytic thrombocytopenia (CAMT) is caused by the loss of thrombopoietin receptor-mediated (MPL-mediated) signaling, which causes severe pancytopenia leading to bone marrow failure with onset of thrombocytopenia and ..
  8. Casari C, Du V, Wu Y, Kauskot A, de Groot P, Christophe O, et al. Accelerated uptake of VWF/platelet complexes in macrophages contributes to VWD type 2B-associated thrombocytopenia. Blood. 2013;122:2893-902 pubmed publisher
    ..Bleeding tendency is associated with heterogeneous clinical manifestations, including moderate to severe thrombocytopenia. The underlying mechanism of the thrombocytopenia has remained unclear...
  9. Weng Y, Chen N, Han Y, Xing Y, Li J. Clinical and laboratory characteristics of severe fever with thrombocytopenia syndrome in Chinese patients. Braz J Infect Dis. 2014;18:88-91 pubmed publisher
    Severe fever with thrombocytopenia syndrome (SFTS) associated with severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging infectious disease...

More Information

Publications79

  1. Wang Y, Wang Z, Wu L, Zhang J, Wang J, Yan L. Recombinant human thrombopoietin is an effective treatment for thrombocytopenia in hemophagocytic lymphohistiocytosis. Ann Hematol. 2013;92:1695-9 pubmed publisher
    The aim of this study was to investigate the effectiveness and safety in the treatment of thrombocytopenia in hemophagocytic lymphohistiocytosis (HLH) by recombinant human thrombopoietin (rhTPO)...
  2. Linkins L, Dans A, Moores L, Bona R, Davidson B, Schulman S, et al. Treatment and prevention of heparin-induced thrombocytopenia: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141:e495S-e530S pubmed publisher
    Heparin-induced thrombocytopenia (HIT) is an antibody-mediated adverse drug reaction that can lead to devastating thromboembolic complications, including pulmonary embolism, ischemic limb necrosis necessitating limb amputation, acute ..
  3. Harinstein L, Kane Gill S, Smithburger P, Culley C, Reddy V, Seybert A. Use of an abnormal laboratory value-drug combination alert to detect drug-induced thrombocytopenia in critically Ill patients. J Crit Care. 2012;27:242-9 pubmed publisher
    ..available clinical decision support system (CDSS) drug-laboratory result alert in detecting drug-induced thrombocytopenia in critically ill patients...
  4. Mantzourani M, Gogas H, Katsandris A, Meletis J. Severe thrombocytopenia related to trastuzumab infusion. Med Sci Monit. 2011;17:CS85-7 pubmed
    ..We report a case of severe thrombocytopenia related to trastuzumab administration...
  5. Chen H, Zheng W, Su J, Xu D, Wang Q, Leng X, et al. Low-dose rituximab therapy for refractory thrombocytopenia in patients with systemic lupus erythematosus--a prospective pilot study. Rheumatology (Oxford). 2011;50:1640-4 pubmed publisher
    To evaluate the safety and efficacy of low-dose rituximab therapy for refractory thrombocytopenia in patients with SLE. Ten adult SLE patients with severe refractory thrombocytopenia (mean platelet count 10...
  6. Tanhehco Y, Rux A, Sachais B. Low-density lipoprotein apheresis reduces platelet factor 4 on the surface of platelets: a possible protective mechanism against heparin-induced thrombocytopenia and thrombosis. Transfusion. 2011;51:1022-9 pubmed publisher
    Heparin-induced thrombocytopenia and thrombosis (HITT) is characterized by thrombocytopenia due to the formation of antibodies against heparin : platelet factor 4 (PF4) complexes...
  7. Junqueira D, Perini E, Penholati R, Carvalho M. Unfractionated heparin versus low molecular weight heparin for avoiding heparin-induced thrombocytopenia in postoperative patients. Cochrane Database Syst Rev. 2012;:CD007557 pubmed publisher
    Heparin-induced thrombocytopenia (HIT) is an adverse drug reaction presenting as a prothrombotic disorder related to antibody-mediated platelet activation...
  8. Kunishima S, Kashiwagi H, Otsu M, Takayama N, Eto K, Onodera M, et al. Heterozygous ITGA2B R995W mutation inducing constitutive activation of the ?IIb?3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia. Blood. 2011;117:5479-84 pubmed publisher
    ..We propose that activating mutations in ITGA2B and ITGB3 represent the etiology of a subset of congenital macrothrombocytopenias...
  9. Giezen T, Mantel Teeuwisse A, Ten Berg M, Straus S, Leufkens H, van Solinge W, et al. Rituximab-induced thrombocytopenia: a cohort study. Eur J Haematol. 2012;89:256-66 pubmed publisher
    ..b>Thrombocytopenia is a known adverse drug reaction of rituximab, which has already been identified during the preregistration ..
  10. Hiraki Y, Tsuji Y, Hiraike M, Misumi N, Matsumoto K, Morita K, et al. Correlation between serum linezolid concentration and the development of thrombocytopenia. Scand J Infect Dis. 2012;44:60-4 pubmed publisher
    ..We demonstrated that trough LZD concentrations correlated with platelet counts. A significant decrease in platelet count was observed in patients with trough LZD concentrations higher than 22.1 ?g/ml. ..
  11. Afdhal N, Giannini E, Tayyab G, Mohsin A, Lee J, Andriulli A, et al. Eltrombopag before procedures in patients with cirrhosis and thrombocytopenia. N Engl J Med. 2012;367:716-24 pubmed publisher
    ..eltrombopag for increasing platelet counts and reducing the need for platelet transfusions in patients with thrombocytopenia and chronic liver disease who are undergoing an elective invasive procedure...
  12. Dasanu C, Codreanu I. Isolated thrombocytopenia: should we routinely screen for antiphospholipid antibodies?. Conn Med. 2011;75:281-4 pubmed
    Antiphospholipid (aPL) antibodies are thought to be present in at least 25% of immune thrombocytopenia patients. Conversely, more than 25% of patients with aPL antibody syndrome (APLAS) present with thrombocytopenia...
  13. Cuker A. Current and emerging therapeutics for heparin-induced thrombocytopenia. Semin Thromb Hemost. 2012;38:31-7 pubmed publisher
    Heparin-induced thrombocytopenia (HIT) is a prothrombotic complication of heparin therapy. Little more than a decade ago, no effective agents were available to treat this devastating and potentially fatal disease...
  14. Yang Q, Xu S, Li X, Wang B, Wang X, Ma D, et al. Pathway of Toll-like receptor 7/B cell activating factor/B cell activating factor receptor plays a role in immune thrombocytopenia in vivo. PLoS ONE. 2011;6:e22708 pubmed publisher
    Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by anti-platelet autoantibody-mediated platelet destruction. Antigen-presenting cell (APC) dysfunction is considered to play crucial roles in ITP...
  15. Hashimoto N, Akahoshi T, Tomikawa M, Kawanaka H, Konishi K, Uehara H, et al. Value of laparoscopic splenectomy as salvage treatment for relapsed thrombocytopenia after partial splenic arterial embolization. Dig Surg. 2010;27:515-20 pubmed publisher
    ..However, relapsed thrombocytopenia is often observed in patients following PSE...
  16. Kang K, Tang X, Xu B, You A, Huang X, Du Y, et al. [Analysis of the epidemic characteristics of fever and thrombocytopenia syndrome in Henan province, 2007 - 2011]. Zhonghua Yu Fang Yi Xue Za Zhi. 2012;46:106-9 pubmed
    To analyze the epidemiological characteristics of fever thrombocytopenia and leukopenia syndrome (FTLS) in Henan province, China in 2007 - 2011...
  17. Pippucci T, Savoia A, Perrotta S, Pujol Moix N, Noris P, Castegnaro G, et al. Mutations in the 5' UTR of ANKRD26, the ankirin repeat domain 26 gene, cause an autosomal-dominant form of inherited thrombocytopenia, THC2. Am J Hum Genet. 2011;88:115-20 pubmed publisher
    THC2, an autosomal-dominant thrombocytopenia described so far in only two families, has been ascribed to mutations in MASTL or ACBD5...
  18. Kai Feng W, Hong Ming P, Hai Zhou L, Li Rong S, Xi Yan Z. Interleukin-11-induced capillary leak syndrome in primary hepatic carcinoma patients with thrombocytopenia. BMC Cancer. 2011;11:204 pubmed publisher
    ..Interleukin-11 (IL-11) is a promising therapeutic agent for thrombocytopenia. A direct correlation between IL-11 and CLS has never been reported previously, particularly in patients with ..
  19. Tanaka Y, Kurosaki M, Nishida N, Sugiyama M, Matsuura K, Sakamoto N, et al. Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C. Hum Mol Genet. 2011;20:3507-16 pubmed publisher
    ..The aim of this study was to identify host factors associated with IFN-induced thrombocytopenia by genome-wide association study (GWAS)...
  20. Geddis A. Congenital amegakaryocytic thrombocytopenia. Pediatr Blood Cancer. 2011;57:199-203 pubmed publisher
    Congenital amegakaryocytic thrombocytopenia (CAMT) is clinically characterized by thrombocytopenia presenting at birth in a child without congenital or skeletal malformations, reduced or absent bone marrow megakaryocytes, and eventual ..
  21. Rossignol J, Michallet A, Oberic L, Picard M, Garon A, Willekens C, et al. Rituximab-cyclophosphamide-dexamethasone combination in the management of autoimmune cytopenias associated with chronic lymphocytic leukemia. Leukemia. 2011;25:473-8 pubmed publisher
    ..Diagnosis of AID was autoimmune hemolytic anemia (AIHA) in 26 (54%), autoimmune thrombocytopenia (AITP) in 9 (18.8%), Evan's syndrome in 8 (16.7%) and pure red cell aplasia (PRCA) in 5 patients (10.5%)...
  22. Sharma A, Charles K, Chadee D, Teelucksingh S. Dengue hemorrhagic fever in Trinidad and Tobago: a case for a conservative approach to platelet transfusion. Am J Trop Med Hyg. 2012;86:531-5 pubmed publisher
    ..16, P < 0.025). No association was found between giving a platelet transfusion and hemoconcentration or hemorrhage. Thrombocytopenia seen in dengue resolves spontaneously and independent of any transfusion used.
  23. de Caprariis D, Dantas Torres F, Capelli G, Mencke N, Stanneck D, Breitschwerdt E, et al. Evolution of clinical, haematological and biochemical findings in young dogs naturally infected by vector-borne pathogens. Vet Microbiol. 2011;149:206-12 pubmed publisher
    ..No abnormal clinical signs were recorded in group A dogs. Thrombocytopenia was the most frequent haematological alteration recorded in A. platys-infected dogs, B...
  24. Chae H, Kim M, Lim J, Oh E, Kim Y, Han K. Novel method to dissociate platelet clumps in EDTA-dependent pseudothrombocytopenia based on the pathophysiological mechanism. Clin Chem Lab Med. 2012;50:1387-91 pubmed publisher
    ..The purpose of this study was to identify antiplatelet antibodies in EDTA-PTCP samples and to design a method to dissociate platelet clumps based on the pathophysiological mechanism...
  25. Celik M, Karakus A, Zeren C, Demir M, Bayaroğullari H, Duru M, et al. Licorice induced hypokalemia, edema, and thrombocytopenia. Hum Exp Toxicol. 2012;31:1295-8 pubmed publisher
    ..In this case report, an association of hypokalemia, edema, and thrombocytopenia that is developed due to the excessive intake of licorice is presented...
  26. Michel M, Te Boekhorst P, Janssens A, Pabinger Fasching I, Sanz M, Nie K, et al. Reduced corticosteroid use in adult patients with primary immune thrombocytopenia receiving romiplostim. Hematology. 2011;16:274-7 pubmed publisher
    lt;title/> Adult patients with primary immune thrombocytopenia requiring first-line treatment typically receive corticosteroids, which are associated with low response rates and many potential side effects...
  27. Huang X, Liu L, Du Y, Ma H, Mu Y, Ma H, et al. Detection of a novel bunyavirus associated with fever, thrombocytopenia and leukopenia syndrome in Henan Province, China, using real-time reverse transcription PCR. J Med Microbiol. 2013;62:1060-4 pubmed publisher
    A novel bunyavirus associated with fever, thrombocytopenia and leukopenia syndrome (FTLS) was discovered in Henan Province, China...
  28. Bender B, Schaedeli Stark F, Koch R, Joshi A, Chu Y, Rugo H, et al. A population pharmacokinetic/pharmacodynamic model of thrombocytopenia characterizing the effect of trastuzumab emtansine (T-DM1) on platelet counts in patients with HER2-positive metastatic breast cancer. Cancer Chemother Pharmacol. 2012;70:591-601 pubmed
    ..b>Thrombocytopenia (TCP) is the dose-limiting toxicity of T-DM1...
  29. da Silva R, Malvezi A, Augusto L, Kian D, Tatakihara V, Yamauchi L, et al. Oral exposure to Phytomonas serpens attenuates thrombocytopenia and leukopenia during acute infection with Trypanosoma cruzi. PLoS ONE. 2013;8:e68299 pubmed publisher
    Mice infected with Trypanosoma cruzi, the agent of Chagas disease, rapidly develop anemia and thrombocytopenia. These effects are partially promoted by the parasite trans-sialidase (TS), which is shed in the blood and depletes sialic acid ..
  30. Krauel K, Hackbarth C, Fürll B, Greinacher A. Heparin-induced thrombocytopenia: in vitro studies on the interaction of dabigatran, rivaroxaban, and low-sulfated heparin, with platelet factor 4 and anti-PF4/heparin antibodies. Blood. 2012;119:1248-55 pubmed publisher
    ..immune complexes activate platelets, leading to the prothrombotic adverse drug reaction heparin-induced thrombocytopenia (HIT). HIT requires treatment with alternative anticoagulants...
  31. Lu J, Li C, Zhang F, Wu W, Zhang Q, Zhang L, et al. [Expression of structural and non-structural proteins of severe fever with thrombocytopenia syndrome bunyavirus]. Bing Du Xue Bao. 2011;27:515-20 pubmed
    Severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) is a novel phlebovirus, causing a life-threatening illness associated with the symptoms of severe fever and thrombocytopenia syndrome...
  32. Ji L, Zhan Y, Hua F, Li F, Zou S, Wang W, et al. The ratio of Treg/Th17 cells correlates with the disease activity of primary immune thrombocytopenia. PLoS ONE. 2012;7:e50909 pubmed publisher
    Primary immune thrombocytopenia (ITP) is an autoimmune heterogeneous disorder that is characterized by decreased platelet count. Regulatory T (Treg) cells and T helper type 17 (Th17) cells are two subtypes of CD4(+) T helper (Th) cells...
  33. Xu B, Liu L, Huang X, Ma H, Zhang Y, Du Y, et al. Metagenomic analysis of fever, thrombocytopenia and leukopenia syndrome (FTLS) in Henan Province, China: discovery of a new bunyavirus. PLoS Pathog. 2011;7:e1002369 pubmed publisher
    Since 2007, many cases of fever, thrombocytopenia and leukopenia syndrome (FTLS) have emerged in Henan Province, China. Patient reports of tick bites suggested that infection could contribute to FTLS...
  34. Coelho H, Lopes S, Pimentel J, Nogueira P, Costa F, Siqueira A, et al. Thrombocytopenia in Plasmodium vivax malaria is related to platelets phagocytosis. PLoS ONE. 2013;8:e63410 pubmed publisher
    Although thrombocytopenia is a hematological disorder commonly reported in malarial patients, its mechanisms are still poorly understood, with only a few studies focusing on the role of platelets phagocytosis...
  35. Vandenberg C, Cory S. ABT-199, a new Bcl-2-specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia. Blood. 2013;121:2285-8 pubmed publisher
    ..However, their interaction with Bcl-xL provokes thrombocytopenia, which has proven to be the dose-limiting toxicity...
  36. Jurak Begonja A, Hoffmeister K, Hartwig J, Falet H. FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly. Blood. 2011;118:2285-95 pubmed publisher
    ..Together, the findings indicate that FlnA-null MKs prematurely release large and fragile platelets that are removed rapidly from the circulation by macrophages. ..
  37. Maina R, Walsh D, Gaddy C, Hongo G, Waitumbi J, Otieno L, et al. Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya. Malar J. 2010;9 Suppl 3:S4 pubmed publisher
    ..When used in combination with other clinical and microscopy, these parameters could improve malaria diagnosis in sub-patent cases. ..
  38. Lam T, Liu W, Bowden T, Cui N, Zhuang L, Liu K, et al. Evolutionary and molecular analysis of the emergent severe fever with thrombocytopenia syndrome virus. Epidemics. 2013;5:1-10 pubmed publisher
    In 2009, a novel Bunyavirus, called severe fever with thrombocytopenia syndrome virus (SFTSV) was identified in the vicinity of Huaiyangshan, China...
  39. Kato S, Takahashi K, Ayabe K, Samad R, Fukaya E, Friedmann P, et al. Heparin-induced thrombocytopenia: analysis of risk factors in medical inpatients. Br J Haematol. 2011;154:373-7 pubmed publisher
    Heparin-induced thrombocytopenia (HIT) is an unpredictable reaction to heparin characterized by thrombocytopenia and increased risk of life-threatening venous and/or arterial thrombosis...
  40. Tadokoro J, Kakihata K, Shimazaki M, Shiozawa T, Masatani S, Yamaguchi F, et al. Post-marketing surveillance (PMS) of all patients treated with irinotecan in Japan: clinical experience and ADR profile of 13,935 patients. Jpn J Clin Oncol. 2011;41:1101-11 pubmed publisher
    ..The actual condition of drug utilization and the adverse drug reactions profile of irinotecan hydrochloride hydrate (irinotecan), an antitumor drug, were examined on the basis of all the case survey results from April 1995 to January 2000...
  41. Hui P, Cook D, Lim W, Fraser G, Arnold D. The frequency and clinical significance of thrombocytopenia complicating critical illness: a systematic review. Chest. 2011;139:271-278 pubmed publisher
    The epidemiology of thrombocytopenia in critically ill patients has not been well characterized...
  42. Hodgson K, Ferrer G, Montserrat E, Moreno C. Chronic lymphocytic leukemia and autoimmunity: a systematic review. Haematologica. 2011;96:752-61 pubmed publisher
    ..chronic lymphocytic leukemia and autoimmune cytopenias, particularly autoimmune hemolytic anemia and immune thrombocytopenia, is well established...
  43. Breakey V, Blanchette V. Childhood immune thrombocytopenia: a changing therapeutic landscape. Semin Thromb Hemost. 2011;37:745-55 pubmed publisher
    Childhood immune thrombocytopenia (ITP) is generally a benign self-limiting disorder of young children with <10% of cases requiring regular platelet enhancing therapy at 1 year following diagnosis...
  44. Krauel K, Pötschke C, Weber C, Kessler W, Fürll B, Ittermann T, et al. Platelet factor 4 binds to bacteria, [corrected] inducing antibodies cross-reacting with the major antigen in heparin-induced thrombocytopenia. Blood. 2011;117:1370-8 pubmed publisher
    A clinically important adverse drug reaction, heparin-induced thrombocytopenia (HIT), is induced by antibodies specific for complexes of the chemokine platelet factor 4 (PF4) and the polyanion heparin...
  45. Kudo T, Sato T, Hagiwara K, Kozuma Y, Yamaguchi T, Ikehara Y, et al. C1galt1-deficient mice exhibit thrombocytopenia due to abnormal terminal differentiation of megakaryocytes. Blood. 2013;122:1649-57 pubmed publisher
    ..Mx1-C1 mice exhibit severe thrombocytopenia, giant platelets, and prolonged bleeding times...
  46. Liu L, Guan X, Xing X, Shen X, Xu J, Yue J, et al. [Epidemiologic analysis on severe fever with thrombocytopenia syndrome in Hubei province, 2010]. Zhonghua Liu Xing Bing Xue Za Zhi. 2012;33:168-72 pubmed
    To identify the epidemic characteristics and risk factors of an emerging infectious disease-severe fever with thrombocytopenia syndrome (SFTS) in Hubei province.
  47. Aslam R, Hu Y, Gebremeskel S, Segel G, Speck E, Guo L, et al. Thymic retention of CD4+CD25+FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia. Blood. 2012;120:2127-32 pubmed publisher
    Immune thrombocytopenia (ITP) is a bleeding disorder in which antibodies and/or T cells lead to enhanced peripheral platelet destruction and reduced bone marrow platelet production...
  48. Herbinger K, Schunk M, Nothdurft H, von Sonnenburg F, Loscher T, Bretzel G. Comparative study on infection-induced thrombocytopenia among returned travellers. Infection. 2012;40:373-9 pubmed publisher
    b>Thrombocytopenia is a frequent finding among ill returned travellers and may be caused by a large number of different conditions, including infectious diseases specific or typical for tropical and subtropical regions...
  49. Bishton M, Harrison S, Martin B, McLaughlin N, James C, Josefsson E, et al. Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor-induced thrombocytopenia. Blood. 2011;117:3658-68 pubmed publisher
    Histone deacetylase inhibitor (HDACI)-induced thrombocytopenia (TCP) is a major dose-limiting toxicity of this new class of drugs...
  50. Roca M, Muñiz Diaz E, Mora J, Romero Zayas I, Ramon O, Roig I, et al. The scintigraphic index spleen/liver at 30 minutes predicts the success of splenectomy in persistent and chronic primary immune thrombocytopenia. Am J Hematol. 2011;86:909-13 pubmed publisher
    Splenectomy is considered the second-line of treatment in patients with chronic primary immune thrombocytopenia (ITP) in whom glucocorticoids have failed...
  51. Tsai Y, Chen C, Kuo C, Lin K. Anti-PF4/heparin antibodies are associated with arteriovenous fistula thrombosis in non-diabetic hemodialysis patients. Clin Exp Nephrol. 2012;16:300-5 pubmed publisher
    ..factor 4/heparin complex antibodies (anti-PF4/heparin Ab) have been found to cause heparin-induced thrombocytopenia (HIT), a clinical syndrome thrombocytopenia and thrombosis...
  52. Kunishima S, Okuno Y, Yoshida K, Shiraishi Y, Sanada M, Muramatsu H, et al. ACTN1 mutations cause congenital macrothrombocytopenia. Am J Hum Genet. 2013;92:431-8 pubmed publisher
    ..Our findings provide an insight into the pathogenesis of CMTP...
  53. Yang C, Yen H, Su W, Chen Y, Soon M. Profound transient thrombocytopenia associated with 90Yttrium microsphere therapy for inoperable hepatoma. South Med J. 2010;103:1264-8 pubmed publisher
    ..The patient displayed bone marrow suppression that resulted in a transient yet profound thrombocytopenia. To our knowledge, this is the first case of a hematologic complication as a consequence of the use of ..
  54. Nydam T, Kashuk J, Moore E, Johnson J, Burlew C, Biffl W, et al. Refractory postinjury thrombocytopenia is associated with multiple organ failure and adverse outcomes. J Trauma. 2011;70:401-6; discussion 406-7 pubmed publisher
    ..Our previous work consistently identified an association between thrombocytopenia and progression to MOF...
  55. Chen H, Hu K, Zou J, Xiao J. A cluster of cases of human-to-human transmission caused by severe fever with thrombocytopenia syndrome bunyavirus. Int J Infect Dis. 2013;17:e206-8 pubmed publisher
    Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease in six epidemic provinces of China and was identified to be caused by a novel bunyavirus in 2009. It is progressive in nature and potentially fatal...
  56. Messmore H, Fabbrini N, Bird M, Choudhury A, Cerejo M, Prechel M, et al. Simple scoring system for early management of heparin-induced thrombocytopenia. Clin Appl Thromb Hemost. 2011;17:197-201 pubmed publisher
    ..a simple scoring system to aid in the early clinical management of patients suspected of heparin-induced thrombocytopenia (HIT) with regard to decisions for continued heparin therapy...
  57. Weitz I, Sanz M, Henry D, Schipperus M, Godeau B, Northridge K, et al. A novel approach to the evaluation of bleeding-related episodes in patients with chronic immune thrombocytopenia. Curr Med Res Opin. 2012;28:789-96 pubmed publisher
    In clinical studies of patients with severe thrombocytopenia, rescue treatments are used to prevent or stop bleeding. Estimating risk reductions of bleeding for clinical study medications can be challenging...
  58. Akahoshi T, Tomikawa M, Kawanaka H, Furusyo N, Kinjo N, Tsutsumi N, et al. Laparoscopic splenectomy with interferon therapy in 100 hepatitis-C-virus-cirrhotic patients with hypersplenism and thrombocytopenia. J Gastroenterol Hepatol. 2012;27:286-90 pubmed publisher
    ..Lap-Sp) contributes to treatment with interferon therapy in hepatitis C virus (HCV)-cirrhotic patients with thrombocytopenia caused by hypersplenism...
  59. Fuchs T, Bhandari A, Wagner D. Histones induce rapid and profound thrombocytopenia in mice. Blood. 2011;118:3708-14 pubmed publisher
    ..Infused histones associated with platelets in vivo and caused a profound thrombocytopenia within minutes after administration...
  60. Lin S, Huang J, Shen M, Chuang S, Lee M, Chen H. Piperacillin-induced thrombocytopenia reversed by high-flux hemodialysis in an uremic patient. Hemodial Int. 2012;16 Suppl 1:S50-3 pubmed publisher
    Drug-induced thrombocytopenia in an infected patient often is overlooked...
  61. Misra D, Das S, Pattnaik M, Singh S, Jena R. Relationship of hepatic and renal dysfunction with haemorrheological parameters in Plasmodium falciparum malaria. J Assoc Physicians India. 2011;59:552-6 pubmed
    ..51) seconds, mean APTT was 29.39 +/- 2.89 seconds and FDP by D-dimer was raised in 30% respectively. Thrombocytopenia was seen in 26% cases in Group A and 15% cases in Group B...
  62. Zhang Y, Conti M, Malide D, Dong F, Wang A, Shmist Y, et al. Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A. Blood. 2012;119:238-50 pubmed publisher
    ..Our results show that heterozygous mice with mutations in the myosin motor or filament-forming domain manifest similar hematologic, eye, and kidney phenotypes to humans with MYH9-related disease...
  63. Kawaguchi T, Komori A, Seike M, Fujiyama S, Watanabe H, Tanaka M, et al. Efficacy and safety of eltrombopag in Japanese patients with chronic liver disease and thrombocytopenia: a randomized, open-label, phase II study. J Gastroenterol. 2012;47:1342-51 pubmed publisher
    ..We evaluated the pharmacokinetics, efficacy, and safety of eltrombopag in Japanese patients with thrombocytopenia associated with chronic liver disease (CLD)...
  64. Yang Q, Wang B, Yu H, Zhu Y, Wang X, Jiang H, et al. TLR7 promotes Th1 polarization in immune thrombocytopenia. Thromb Res. 2011;128:237-42 pubmed publisher
    T helper 1 cell (Th1) polarization persists in the autoimmune response found in immune thrombocytopenia (ITP)...
  65. Pollak U, Yacobobich J, Tamary H, Dagan O, Manor Shulman O. Heparin-induced thrombocytopenia and extracorporeal membrane oxygenation: a case report and review of the literature. J Extra Corpor Technol. 2011;43:5-12 pubmed
    Heparin-induced thrombocytopenia (HIT) is an immune-mediated coagulation side effect of heparin therapy characterized by thrombocytopenia and by a paradoxical prothrombotic state following heparin exposure when thrombotic or ..
  66. Pleines I, Hagedorn I, Gupta S, May F, Chakarova L, van Hengel J, et al. Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis. Blood. 2012;119:1054-63 pubmed publisher
    ..Together, these results establish RhoA as an important regulator of platelet function in thrombosis and hemostasis...
  67. Iancu Rubin C, Gajzer D, Mosoyan G, Feller F, Mascarenhas J, Hoffman R. Panobinostat (LBH589)-induced acetylation of tubulin impairs megakaryocyte maturation and platelet formation. Exp Hematol. 2012;40:564-74 pubmed publisher
    Drug-induced thrombocytopenia often results from dysregulation of normal megakaryocytopoiesis...
  68. Stuge T, Skogen B, Ahlen M, Husebekk A, Urbaniak S, Bessos H. The cellular immunobiology associated with fetal and neonatal alloimmune thrombocytopenia. Transfus Apher Sci. 2011;45:53-9 pubmed publisher
    Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is caused by maternal antibodies that cross the placenta in connection with pregnancy and destroy fetal platelets...
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    Heparin-induced thrombocytopenia (HIT) is a rare complication of heparin therapy resulting from antibody production to platelet factor 4 and heparin complexes (H-PF4)...
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    ..These data suggest that it may be unnecessary to generate platelets from ex vivo grown megakaryocytes to achieve clinically relevant increases in platelet numbers...