thrombocytopenic purpura

Summary

Summary: Any form of purpura in which the PLATELET COUNT is decreased. Many forms are thought to be caused by immunological mechanisms.

Top Publications

  1. Sandler S, Novak S, Roland B. The cost of treating immune thrombocytopenic purpura using intravenous Rh immune globulin versus intravenous immune globulin. Am J Hematol. 2000;63:156-8 pubmed
    Multiple factors, including efficacy, toxicity and cost, may influence the decision to treat immune thrombocytopenic purpura (ITP) with intravenous immune globulin (IVIG) or intravenous Rho (D) immune globulin (IV RhIG)...
  2. Garderet L, Maury E, Lagrange M, Najman A, Offenstadt G, Guidet B. Schizocytosis in pernicious anemia mimicking thrombotic thrombocytopenic purpura. Am J Med. 2003;114:423-5 pubmed
  3. Zhou Z, Yang L, Chen Z, Chen X, Guo Y, Wang X, et al. Health-related quality of life measured by the Short Form 36 in immune thrombocytopenic purpura: a cross-sectional survey in China. Eur J Haematol. 2007;78:518-23 pubmed
    The aim of this study is to assess the quality of life (QoL) of Chinese adults with idiopathic thrombocytopenic purpura (ITP)...
  4. Tao Z, Anthony K, Peng Y, Choi H, Nolasco L, Rice L, et al. Novel ADAMTS-13 mutations in an adult with delayed onset thrombotic thrombocytopenic purpura. J Thromb Haemost. 2006;4:1931-5 pubmed
    Thrombotic thrombocytopenic purpura (TTP) is associated with congenital and acquired deficiency of ADAMTS-13, a metalloprotease that cleaves von Willebrand factor (VWF) and reduces its adhesive activity...
  5. Cooper N, Woloski B, Fodero E, Novoa M, Leber M, Beer J, et al. Does treatment with intermittent infusions of intravenous anti-D allow a proportion of adults with recently diagnosed immune thrombocytopenic purpura to avoid splenectomy?. Blood. 2002;99:1922-7 pubmed
    ..whether repeated infusions of intravenous anti-D could allow adults with recently diagnosed immune thrombocytopenic purpura (ITP) who had failed an initial steroid course to postpone and ultimately avoid splenectomy...
  6. Sandler S, Tutuncuoglu S. Immune thrombocytopenic purpura - current management practices. Expert Opin Pharmacother. 2004;5:2515-27 pubmed
    The treatment of patients with immune thrombocytopenic purpura (ITP) is changing rapidly, as new agents demonstrate the capability of improving outcomes and decreasing toxicity...
  7. Solanilla A, Pasquet J, Viallard J, Contin C, Grosset C, Dechanet Merville J, et al. Platelet-associated CD154 in immune thrombocytopenic purpura. Blood. 2005;105:215-8 pubmed
    ..In this study, we show that platelet-associated CD154 is increased in immune thrombocytopenic purpura (ITP), a disease characterized by an autoimmune response against proteins of the platelet membrane...
  8. Boehlen F, Balavoine J, de Moerloose P. Severe thrombocytopenic purpura due to rubella infection in a patient with systemic lupus erythematosus. Lupus. 2003;12:144-6 pubmed
    We report the case of a woman suffering from systemic lupus erythematosus who developed a severe thrombocytopenic purpura (platelet count < 1 x 10(9)/l) secondary to rubella infection...
  9. Matzdorff A, Arnold G. Treatment of chronic immune thrombocytopenic purpura: the patients' perspective. Eur J Haematol. 2007;78:381-8 pubmed
    The 1996 ASH guidelines recommend glucocorticoids and splenectomy as standard treatment of chronic immune thrombocytopenic purpura (ITP)...

More Information

Publications62

  1. Mathias S, Bussel J, George J, McMillan R, Okano G, Nichol J. A disease-specific measure of health-related quality of life for use in adults with immune thrombocytopenic purpura: its development and validation. Health Qual Life Outcomes. 2007;5:11 pubmed
    ..measures are available to assess health-related quality of life (HRQoL) in adult subjects with immune thrombocytopenic purpura (ITP)...
  2. Gaines A. Acute onset hemoglobinemia and/or hemoglobinuria and sequelae following Rh(o)(D) immune globulin intravenous administration in immune thrombocytopenic purpura patients. Blood. 2000;95:2523-9 pubmed
    ..by the United States Food and Drug Administration (FDA) in March 1995 to treat patients with immune thrombocytopenic purpura (ITP)...
  3. Tongyoo S, Vilaichone W, Sukpanichnant S, Auewarakul C, Chaiprasert A, Ratanarat R, et al. Thrombocytopenic purpura associated with miliary tuberculosis. J Med Assoc Thai. 2003;86:976-80 pubmed
    ..Bone marrow examination is very helpful in this situation...
  4. Pace D, Chiasson P, Schlachta C, Mamazza J, Poulin E. Laparoscopic splenectomy for idiopathic thrombocytopenic purpura (ITP). Surg Endosc. 2003;17:95-8 pubmed
    ..We report our long-term follow-up data in patients who underwent LS for idiopathic thrombocytopenic purpura (ITP)...
  5. Gaines A. Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rh(0)(D) immune globulin intravenous administration for immune thrombocytopenic purpura. Blood. 2005;106:1532-7 pubmed
    ..licensed Rh(o)(D) immune globulin intravenous (anti-D IGIV) on March 24, 1995, for treatment of immune thrombocytopenic purpura (ITP)...
  6. Sodhi P, Jose R. Subconjunctival hemorrhage: the first presenting clinical feature of idiopathic thrombocytopenic purpura. Jpn J Ophthalmol. 2003;47:316-8 pubmed
    Subconjunctival hemorrhage as the first presenting clinical feature of idiopathic thrombocytopenic purpura, to the best of our knowledge, has not been reported earlier...
  7. Hoshino A, Okada S, Yoshida K, Nishida N, Okuno Y, Ueno H, et al. Abnormal hematopoiesis and autoimmunity in human subjects with germline IKZF1 mutations. J Allergy Clin Immunol. 2017;140:223-231 pubmed publisher
    ..Four of 9 patients had autoimmune disease, including immune thrombocytopenic purpura, IgA vasculitis, and systemic lupus erythematosus. Nonautoimmune pancytopenia was observed in 1 patient...
  8. Noone D, Riedl M, Licht C. The role of von Willebrand factor in thrombotic microangiopathy. Pediatr Nephrol. 2018;33:1297-1307 pubmed publisher
    ..The disease spectrum of TMA includes, amongst others, thrombotic thrombocytopenic purpura (TTP) and atypical haemolytic uraemic syndrome (aHUS)...
  9. Onan B, Aydin U, Kahraman Z, Bakir I. Robotic surgery for atrial septal defect closure in a case of Kabuki syndrome. Turk Kardiyol Dern Ars. 2017;45:77-81 pubmed publisher
    ..female with KS who presented with ostium secundum atrial septal defect with deficient rim and idiopathic thrombocytopenic purpura. In this case, minimally invasive robotic surgery was preferred for closure of atrial septal defect.
  10. Sarbay H, Kocamaz H, Akin M, Ozhan B. Investigation of celiac disease followed by immune thrombocytopenic purpura diagnosis in patients and comparison with literature. North Clin Istanb. 2017;4:160-164 pubmed publisher
    Celiac disease (CD) and Immune thrombocytopenic purpura (ITP) may occur together as a result of similar autoimmune mechanisms. The aim of this study was to assess the frequency of CD in a group of ITP patients and in the literature.
  11. Nurden A, Nurden P. Increasing the platelet count in chronic ITP. Lancet. 2008;371:362-4 pubmed publisher
  12. Terashita S, Hirano K, Hirai T, Narabayashi T, Hara Y, Endo K, et al. [Successful treatment of small cell lung cancer with secondary immune thrombocytopenic purpura]. Nihon Kokyuki Gakkai Zasshi. 2009;47:1036-40 pubmed
    ..Blood biochemistry and bone marrow puncture revealed immune thrombocytopenic purpura (ITP). We speculated that she had secondary ITP (ITP-like syndrome) associated with cancer...
  13. D Arena G, Luigiavigliotti M, Coccaro M, Iodice G, Tartarone A, Matera R, et al. Late and long-lasting response in an adult chronic idiopathic thrombocytopenic purpura after extended course of rituximab. Leuk Lymphoma. 2003;44:561-2 pubmed
  14. Morton J, George J. Microangiopathic Hemolytic Anemia and Thrombocytopenia in Patients With Cancer. J Oncol Pract. 2016;12:523-30 pubmed publisher
    ..is a term used to describe multiple syndromes caused by microvascular thrombosis, including thrombotic thrombocytopenic purpura (TTP), Shiga toxin-mediated hemolytic uremic syndrome, and complement-mediated TMA...
  15. Tsai J, Sherman S. Aortic dissection in a young man with immune thrombocytopenic purpura. J Emerg Med. 2005;28:285-8 pubmed
    ..He did, however, suffer from untreated, chronic immune thrombocytopenic purpura (ITP) and had a platelet count less than 20,000/mm(3) on admission...
  16. Hall J, Mason J, Choi J, Holguin M. B12 deficiency leading to marked poikilocytosis versus true schistocytosis, a pernicious problem. Transfus Apher Sci. 2017;56:576-577 pubmed publisher
    ..LDH), thrombocytopenia, and a low reticulocyte count, which can be incorrectly diagnosed as thrombotic thrombocytopenic purpura and managed incorrectly...
  17. Jamasbi J, Ayabe K, Goto S, Nieswandt B, Peter K, Siess W. Platelet receptors as therapeutic targets: Past, present and future. Thromb Haemost. 2017;117:1249-1257 pubmed publisher
    ..Some of them may also be helpful in treating less frequent diseases such as thrombotic thrombocytopenic purpura. The present concise review aims to cover current and future developments of anti-platelet drugs ..
  18. Berti de Marinis G, Novello S, Ferrari S, Barzon I, Cortella I, Businaro M, et al. Correlation between ADAMTS13 activity and neurological impairment in acute thrombotic microangiopathy patients. J Thromb Thrombolysis. 2016;42:586-92 pubmed publisher
    Differential diagnosis between thrombotic thrombocytopenic purpura (TTP) and other thrombotic microangiopathies (TMA) is usually difficult because of frequently overlapping clinical presentations...
  19. Takahama H, Tazaki H. Tosufloxacin tosilate-induced thrombocytopenic purpura. J Dermatol. 2007;34:465-7 pubmed
    ..We experienced a 69-year-old male who developed thrombocytopenic purpura due to tosufloxacin tosilate...
  20. Bendapudi P, Hurwitz S, Fry A, Marques M, Waldo S, Li A, et al. Derivation and external validation of the PLASMIC score for rapid assessment of adults with thrombotic microangiopathies: a cohort study. Lancet Haematol. 2017;4:e157-e164 pubmed publisher
    Among the syndromes characterised by thrombotic microangiopathy, thrombotic thrombocytopenic purpura is distinguished by a severe deficiency in the ADAMTS13 enzyme. Patients with this disorder need urgent treatment with plasma exchange...
  21. Chaudhary U, Eberwine S, Hege K. Acquired amegakaryocytic thrombocytopenia purpura and eosinophilic fasciitis: a long relapsing and remitting course. Am J Hematol. 2004;75:146-50 pubmed
    ..Later in the treatment course, dosing of anti-thymocyte globulin (ATG) appeared to have important beneficial contributions in the management of this patient's disease. ..
  22. Bisogno G. Persistent B-cell depletion after rituximab for thrombocytopenic purpura. Eur J Pediatr. 2007;166:85-6 pubmed
  23. Kashyap R, Choudhry V, Pati H. Danazol therapy in cyclic acquired amegakaryocytic thrombocytopenic purpura: a case report. Am J Hematol. 1999;60:225-8 pubmed
    Cyclic acquired amegakaryocytic thrombocytopenic purpura (AATP) is a rare disorder characterized by periodic fluctuations in the platelet counts due to a defect in the platelet production...
  24. Choi S, Brull R. Neuraxial techniques in obstetric and non-obstetric patients with common bleeding diatheses. Anesth Analg. 2009;109:648-60 pubmed publisher
    ..the most common bleeding diatheses, including hemophilia, von Willebrand's disease (vWD), and idiopathic thrombocytopenic purpura (ITP)...
  25. Demirsoy E, Mehtap O, Atesoglu E, Tarkun P, Eren N, Geduk A, et al. Dasatinib-induced immune mediated-thrombotic thrombocytopenic purpura. Transfus Apher Sci. 2018;57:222-224 pubmed publisher
    ..Besides, with dasatinib autoimmune side effects can be seen. Thrombotic thrombocytopenic purpura (TTP) is a life- threatening disease that can be related to various causes mainly autoimmune disorders or ..
  26. Aref S, El Ghonemy M, El Aziz S, Abouzeid T, Talaab M, El Sabbagh A. Impact of serum immunoglobulins level and IL-18 promoter gene polymorphism among Egyptian patients with idiopathic thrombocytopenic purpura. Hematology. 2017;22:99-104 pubmed publisher
    Based on the concept of immune dysregulation in immune thrombocytopenic purpura (ITP) and that Interleukin-18 (IL-18) is an inflammatory cytokine that plays an important role in autoimmune disease by inducing interferon-? secretion; this ..
  27. Krieg S, Studt J, Sulzer I, Lammle B, Kremer Hovinga J. Is factor V Leiden a risk factor for thrombotic microangiopathies without severe ADAMTS 13 deficiency?. Thromb Haemost. 2005;94:1186-9 pubmed
    About 60% of patients diagnosed with acute thrombotic thrombocytopenic purpura (TTP) display a severe ADAMTS13 deficiency. Recently, Raife et al...
  28. Segna D, Dufour J. Other Extrahepatic Manifestations of Hepatitis C Virus Infection (Pulmonary, Idiopathic Thrombocytopenic Purpura, Nondiabetes Endocrine Disorders). Clin Liver Dis. 2017;21:607-629 pubmed publisher
    ..on the association between HCV and endocrine and pulmonary manifestations, as well as idiopathic thrombocytopenic purpura (ITP)...
  29. Kofteridis D, Mantadakis E, Mixaki I, Stefanidou M, Maraki S, Alexandrakis M, et al. Primary cutaneous nocardiosis in 2 patients on immunosuppressants. Scand J Infect Dis. 2005;37:507-10 pubmed
    ..The first was associated with polymyositis and the second with chronic immune thrombocytopenic purpura. Both patients had received corticosteroids...
  30. Winters J. Plasma exchange in thrombotic microangiopathies (TMAs) other than thrombotic thrombocytopenic purpura (TTP). Hematology Am Soc Hematol Educ Program. 2017;2017:632-638 pubmed publisher
    ..The most commonly thought-of TMA is thrombotic thrombocytopenic purpura (TTP)...
  31. Zuo B, Zhao Y, Yang J, He Y. [Correlation of Plasma Co-stimulatory Molecules B7-H2 and B7-H3 with Platelet Auto-antibodies in Patients with Immune Thrombocytopenic Purpura]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015;23:1075-80 pubmed publisher
  32. Coles A, Compston D, Selmaj K, Lake S, Moran S, Margolin D, et al. Alemtuzumab vs. interferon beta-1a in early multiple sclerosis. N Engl J Med. 2008;359:1786-801 pubmed publisher
    ..Alemtuzumab, a humanized monoclonal antibody that targets CD52 on lymphocytes and monocytes, may be an effective treatment for early multiple sclerosis...
  33. Randen I, Sørensen K, Killie M, Kjeldsen Kragh J. Rapid and reliable genotyping of human platelet antigen (HPA)-1, -2, -3, -4, and -5 a/b and Gov a/b by melting curve analysis. Transfusion. 2003;43:445-50 pubmed
    The probability for occurrence of neonatal alloimmune thrombocytopenic purpura (NAITP) depends largely on the frequency of each individual phenotype in various populations...
  34. Shirasugi Y, Ando K, Hashino S, Nagasawa T, Kurata Y, Kishimoto Y, et al. A phase II, open-label, sequential-cohort, dose-escalation study of romiplostim in Japanese patients with chronic immune thrombocytopenic purpura. Int J Hematol. 2009;90:157-165 pubmed publisher
    ..a novel peptibody that increases platelet production, in Japanese patients with chronic immune thrombocytopenic purpura (ITP)...
  35. Karpatkin S, Nardi M, Green D. Platelet and coagulation defects associated with HIV-1-infection. Thromb Haemost. 2002;88:389-401 pubmed
  36. Maistrenko N, Andreev A, Sukhopara I. [Laparoscopic splenectomy through a lateral access]. Vestn Khir Im I I Grek. 2004;163:79-83 pubmed
  37. Roca B. [Extrahepatic manifestations of hepatitis C virus infection]. Enferm Infecc Microbiol Clin. 2004;22:467-70 pubmed
    ..In some patients with hepatitis C virus infection, the extrahepatic manifestations predominate and their proper diagnosis and management is very important. ..
  38. Clark W, Huang S, Walsh M, Farah M, Hildebrand A, Sontrop J. Plasmapheresis for the treatment of kidney diseases. Kidney Int. 2016;90:974-984 pubmed publisher
    ..for plasma exchange based on 2014 registry data from the Canadian Apheresis Group: (i) thrombotic thrombocytopenic purpura (TTP)/hemolytic uremic syndrome; (ii) renal transplantation, (iii) anti-neutrophil cytoplasm antibodies-..
  39. Bay A, Oner A, Etlik O, Caksen H. A case of immune thrombocytopenic purpura presenting with recurrent intracranial hemorrhage. Pediatr Int. 2005;47:109-11 pubmed
  40. Whitaker H, Farrington C, Spiessens B, Musonda P. Tutorial in biostatistics: the self-controlled case series method. Stat Med. 2006;25:1768-97 pubmed
    ..Some brief pointers on the design of case series studies are provided. The data sets, STATA code, and further implementation details in SAS, GENSTAT and GLIM are available from an associated website. ..
  41. Brophy T, Ward S, McGimsey T, Schneppenheim S, Drakeford C, O Sullivan J, et al. Plasmin Cleaves Von Willebrand Factor at K1491-R1492 in the A1-A2 Linker Region in a Shear- and Glycan-Dependent Manner In Vitro. Arterioscler Thromb Vasc Biol. 2017;37:845-855 pubmed publisher
    ..a disintegrin and metalloproteinase with thrombospondin type 1 motif) in a mouse model of thrombotic thrombocytopenic purpura. Consequently, elucidating the molecular mechanisms through which plasmin binds and cleaves VWF is not ..
  42. Blakeley J, Ye X, Duda D, Halpin C, Bergner A, Muzikansky A, et al. Efficacy and Biomarker Study of Bevacizumab for Hearing Loss Resulting From Neurofibromatosis Type 2-Associated Vestibular Schwannomas. J Clin Oncol. 2016;34:1669-75 pubmed publisher
    ..Three grade 3 adverse events, hypertension (n = 2) and immune-mediated thrombocytopenic purpura (n = 1), were possibly related to bevacizumab...
  43. Lin Y, Zhou X, Guo W, Li Q, Pan X, Bao Y, et al. RhIL-11 treatment normalized Th1/Th2 and T-bet/GATA-3 imbalance in in human immune thrombocytopenic purpura (ITP). Int Immunopharmacol. 2016;38:40-4 pubmed publisher
    ..Thus our study suggested rhIL-11 was effective with tolerable adverse effects in ITP. The treatment strategy warrants further clinical investigation. ..
  44. Le Besnerais M, Favre J, Denis C, Mulder P, Martinet J, Nicol L, et al. Assessment of endothelial damage and cardiac injury in a mouse model mimicking thrombotic thrombocytopenic purpura. J Thromb Haemost. 2016;14:1917-1930 pubmed publisher
    Essentials Endothelial injury is thought to be a key event in thrombotic thrombocytopenic purpura (TTP). Endothelial and cardiac damages were assessed in a model of TTP using ADAMTS-13 knockout mice...
  45. Tishler M, Levy O, Amit Vazina M. Immune thrombocytopenic purpura following influenza vaccination. Isr Med Assoc J. 2006;8:322-3 pubmed
  46. Guiziry D, El G, Farahat N, Hassab H. Phenotypic analysis of bone marrow lymphocytes from children with acute thrombocytopenic purpura. Egypt J Immunol. 2005;12:9-14 pubmed
    ..was to determine the incidence and clinical impact of bone marrow hematogones in cases of acute immune thrombocytopenic purpura (ITP) among children...
  47. Kang M, Hahm J, Jung T, Lee G, Kim D, Park M. A 20-year-old woman with Hashimoto's thyroiditis and Evans' syndrome. Yonsei Med J. 2006;47:432-6 pubmed
    ..Two years and five months later, she developed idiopathic thrombocytopenic purpura (ITP) and was diagnosed with Evans' syndrome...
  48. Rodriguez Calvillo M, Gabari I, Duarte M, Mazzolini G, Rifon J, Rocha E, et al. Thrombopenic purpura induced by a monoclonal antibody directed to a 35-kilodalton surface protein (p35) expressed on murine platelets and endothelial cells. Exp Hematol. 2001;29:589-95 pubmed
    ..Our results show induction of thrombocytopenic purpura in mice with an mAb against a single antigenic determinant expressed on both platelets and endothelium...
  49. Daphnis E, Stylianou K, Alexandrakis M, Xylouri I, Vardaki E, Stratigis S, et al. Acute renal failure, translocational hyponatremia and hyperkalemia following intravenous immunoglobulin therapy. Nephron Clin Pract. 2007;106:c143-8 pubmed
    ..We retrospectively evaluated a cohort of 66 unselected patients with idiopathic thrombocytopenic purpura, who received 140 courses of IVIG therapy...
  50. Hu Y, Liu J, Zhu Y, Lu N. The Importance of Toll-like Receptors in NF-κB Signaling Pathway Activation by Helicobacter pylori Infection and the Regulators of this Response. Helicobacter. 2016;21:428-40 pubmed publisher
    ..to gastric diseases and some extragastric diseases, including iron-deficiency anemia and idiopathic thrombocytopenic purpura. Both the Maastricht IV/Florence consensus report and the Kyoto global consensus report have proposed the ..
  51. Ozdil B, Akkiz H, Sandikci M, Kece C, Cosar A. Recurrent hypersplenism caused by giant accessory spleen due to portal hypertension after splenectomia. Platelets. 2010;21:70-1 pubmed publisher
    Splenectomy is one of the primary choices of treatment in immune thrombocytopenic purpura. However, the disease may relapse despite splenectomy...
  52. Deroux A, Sirodot M, Daguindau N, Barro C, Coppo P, Bouillet L. [Management of thrombotic thrombocytopenic purpura in two French centers: A series of 27 patients]. Rev Med Interne. 2016;37:13-8 pubmed publisher
    Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy due to platelet microthrombosis involved in multiple systems associated with multiple organ dysfunctions and often severe disease course...
  53. Lande M, Thomas G, Houghton D. Membranous nephropathy associated with chronic immune thrombocytopenic purpura in childhood. Am J Kidney Dis. 2001;37:E40 pubmed
    ..We describe a child with membranous nephropathy associated with chronic immune thrombocytopenic purpura (ITP) and Coombs'-positive hemolytic anemia...