activated protein c resistance

Summary

Summary: A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance.

Top Publications

  1. Prochazka M, Krcova V, Hrachovec P, Kudela M, Slavik L. [Activated protein C resistance and deep venous thrombosis in pregnancy]. Ceska Gynekol. 2002;67:251-4 pubmed
    ..Factor V appeared in II (33.3%) women, in comparison to 3 (5.9%) women in the control group. APC resistance and factor V. Leiden represent as important factors in the aetiology of deep venous thrombosis in pregnancy. ..
  2. Nagy V, Facsko A, Takacs L, Balazs E, Berta A, Balogh I, et al. Activated protein C resistance in anterior ischaemic optic neuropathy. Acta Ophthalmol Scand. 2004;82:140-3 pubmed
    ..021). The high frequency of Leiden mutation in NAION suggests a pathogenic role of the mutation in the disease. ..
  3. Mahieu B, Jacobs N, Mahieu S, Naelaerts K, Vertessen F, Weyler J, et al. Haemostatic changes and acquired activated protein C resistance in normal pregnancy. Blood Coagul Fibrinolysis. 2007;18:685-8 pubmed
    ..The clinical significance of this finding should be determined because it complicates the interpretation of lowered APC-SR. ..
  4. Mosnier L, Zlokovic B, Griffin J. The cytoprotective protein C pathway. Blood. 2007;109:3161-72 pubmed
  5. Kassis J, Neville C, Rauch J, Busque L, Chang E, Joseph L, et al. Antiphospholipid antibodies and thrombosis: association with acquired activated protein C resistance in venous thrombosis and with hyperhomocysteinemia in arterial thrombosis. Thromb Haemost. 2004;92:1312-9 pubmed
    ..between factor V Leiden and venous thrombosis, hyperhomocysteinemia and arterial thrombosis, and activated protein C resistance (APCR) and venous thrombosis (OR, 95% CI = 4.00, 1.35-11.91; 4.79, 2.03-11.33; and 2.03, 1.03-3...
  6. Dawood F, Mountford R, Farquharson R, Quenby S. Genetic polymorphisms on the factor V gene in women with recurrent miscarriage and acquired APCR. Hum Reprod. 2007;22:2546-53 pubmed
    Recurrent miscarriage (RM) has been associated with the thrombophilia, activated protein C resistance (APCR)...
  7. Scanavini D, Legnani C, Lunghi B, Mingozzi F, Palareti G, Bernardi F. The factor VIII D1241E polymorphism is associated with decreased factor VIII activity and not with activated protein C resistance levels. Thromb Haemost. 2005;93:453-6 pubmed
    ..Our findings point toward the presence of genetic determinant of coagulation factor levels with a biologically significant role, but with a poor predictive value to estimate thrombotic risk beyond established risk factors. ..
  8. Sedano S, Gaffney G, Mortimer G, Lyons M, Cleary B, Murray M, et al. Activated protein C resistance (APCR) and placental fibrin deposition. Placenta. 2008;29:833-7 pubmed publisher
    b>Activated protein C resistance (APCR) results in an ineffective anticoagulant response leading to an increased risk of thrombosis, particularly during pregnancy...
  9. Soria J, Almasy L, Souto J, Buil A, Martinez Sanchez E, Mateo J, et al. A new locus on chromosome 18 that influences normal variation in activated protein C resistance phenotype and factor VIII activity and its relation to thrombosis susceptibility. Blood. 2003;101:163-7 pubmed
    b>Activated protein C resistance (APCR) is the most prevalent risk factor for thrombosis, accounting for 20% to 60% of familial thrombophilia...
  10. Negaard H, Iversen P, Ostenstad B, Mowinckel M, Sandset P. Increased acquired activated protein C resistance in unselected patients with hematological malignancies. J Thromb Haemost. 2008;6:1482-7 pubmed publisher
    ..Decreased levels of protein S and TF pathway inhibitor were inversely correlated to APC resistance. APC resistance may contribute to the hypercoagulable state in hematological malignancies. ..

Detail Information

Publications62

  1. Prochazka M, Krcova V, Hrachovec P, Kudela M, Slavik L. [Activated protein C resistance and deep venous thrombosis in pregnancy]. Ceska Gynekol. 2002;67:251-4 pubmed
    ..Factor V appeared in II (33.3%) women, in comparison to 3 (5.9%) women in the control group. APC resistance and factor V. Leiden represent as important factors in the aetiology of deep venous thrombosis in pregnancy. ..
  2. Nagy V, Facsko A, Takacs L, Balazs E, Berta A, Balogh I, et al. Activated protein C resistance in anterior ischaemic optic neuropathy. Acta Ophthalmol Scand. 2004;82:140-3 pubmed
    ..021). The high frequency of Leiden mutation in NAION suggests a pathogenic role of the mutation in the disease. ..
  3. Mahieu B, Jacobs N, Mahieu S, Naelaerts K, Vertessen F, Weyler J, et al. Haemostatic changes and acquired activated protein C resistance in normal pregnancy. Blood Coagul Fibrinolysis. 2007;18:685-8 pubmed
    ..The clinical significance of this finding should be determined because it complicates the interpretation of lowered APC-SR. ..
  4. Mosnier L, Zlokovic B, Griffin J. The cytoprotective protein C pathway. Blood. 2007;109:3161-72 pubmed
  5. Kassis J, Neville C, Rauch J, Busque L, Chang E, Joseph L, et al. Antiphospholipid antibodies and thrombosis: association with acquired activated protein C resistance in venous thrombosis and with hyperhomocysteinemia in arterial thrombosis. Thromb Haemost. 2004;92:1312-9 pubmed
    ..between factor V Leiden and venous thrombosis, hyperhomocysteinemia and arterial thrombosis, and activated protein C resistance (APCR) and venous thrombosis (OR, 95% CI = 4.00, 1.35-11.91; 4.79, 2.03-11.33; and 2.03, 1.03-3...
  6. Dawood F, Mountford R, Farquharson R, Quenby S. Genetic polymorphisms on the factor V gene in women with recurrent miscarriage and acquired APCR. Hum Reprod. 2007;22:2546-53 pubmed
    Recurrent miscarriage (RM) has been associated with the thrombophilia, activated protein C resistance (APCR)...
  7. Scanavini D, Legnani C, Lunghi B, Mingozzi F, Palareti G, Bernardi F. The factor VIII D1241E polymorphism is associated with decreased factor VIII activity and not with activated protein C resistance levels. Thromb Haemost. 2005;93:453-6 pubmed
    ..Our findings point toward the presence of genetic determinant of coagulation factor levels with a biologically significant role, but with a poor predictive value to estimate thrombotic risk beyond established risk factors. ..
  8. Sedano S, Gaffney G, Mortimer G, Lyons M, Cleary B, Murray M, et al. Activated protein C resistance (APCR) and placental fibrin deposition. Placenta. 2008;29:833-7 pubmed publisher
    b>Activated protein C resistance (APCR) results in an ineffective anticoagulant response leading to an increased risk of thrombosis, particularly during pregnancy...
  9. Soria J, Almasy L, Souto J, Buil A, Martinez Sanchez E, Mateo J, et al. A new locus on chromosome 18 that influences normal variation in activated protein C resistance phenotype and factor VIII activity and its relation to thrombosis susceptibility. Blood. 2003;101:163-7 pubmed
    b>Activated protein C resistance (APCR) is the most prevalent risk factor for thrombosis, accounting for 20% to 60% of familial thrombophilia...
  10. Negaard H, Iversen P, Ostenstad B, Mowinckel M, Sandset P. Increased acquired activated protein C resistance in unselected patients with hematological malignancies. J Thromb Haemost. 2008;6:1482-7 pubmed publisher
    ..Decreased levels of protein S and TF pathway inhibitor were inversely correlated to APC resistance. APC resistance may contribute to the hypercoagulable state in hematological malignancies. ..
  11. Jadaon M, Dashti A, Lewis H. High prevalence of activated protein C resistance and factor V Leiden mutation in an Arab population and patients with venous thrombosis in Kuwait. Diagn Mol Pathol. 2010;19:180-3 pubmed
    b>Activated protein C resistance (APC-R) because of clotting factor V Leiden mutation (FVL; Arg506Gln; G1691A) is a risk factor for the development of venous thromboembolic disorders (VTE)...
  12. Chegeni R, Kazemi B, Hajifathali A, Pourfathollah A, Lari G. Factor V mutations in Iranian patients with activated protein C resistance and venous thrombosis. Thromb Res. 2007;119:189-93 pubmed
  13. Hoekema L, Castoldi E, Tans G, Girelli D, Gemmati D, Bernardi F, et al. Functional properties of factor V and factor Va encoded by the R2-gene. Thromb Haemost. 2001;85:75-81 pubmed
  14. Cui J, Eitzman D, Westrick R, Christie P, Xu Z, Yang A, et al. Spontaneous thrombosis in mice carrying the factor V Leiden mutation. Blood. 2000;96:4222-6 pubmed
    ..Blood. 2000;96:4222-4226) ..
  15. Kalpage H, Sumathipala D, Goonasekara H, Dissanayake V. A Study on Hereditary Thrombophilia and Stroke in a Cohort from Sri Lanka. J Stroke Cerebrovasc Dis. 2016;25:102-9 pubmed publisher
    ..6) years, respectively. MTHFR c.677C>T is the predominant mutation and the only mutation that had patients with the homozygous mutant genotype. Venous thrombosis showed a significant association with the F5 c.1691G>A mutation. ..
  16. Wan Ab Rahman W, Abdullah W, Hassan M, Hussin A, Zulkafli Z, Haron J. Familial antithrombin III deficiency in a Malay patient with massive thrombosis. Malays J Pathol. 2017;39:197-200 pubmed
    ..study showed reduced AT III activity (38?l/dl) and normal results for protein C, protein S, activated protein C resistance and lupus anticoagulant assays...
  17. Castoldi E, Rosing J. APC resistance: biological basis and acquired influences. J Thromb Haemost. 2010;8:445-53 pubmed publisher
    ..This paper reviews the multifactorial etiology of APC resistance and discusses its clinical implications. ..
  18. Muwakkit S, Saab R, Sanjad S, Bhar S, Ishak R, Samad Z, et al. Renal venous thrombosis in a newborn with prothrombotic risk factors. Blood Coagul Fibrinolysis. 2009;20:458-60 pubmed publisher
    ..This case and other studies clearly demonstrate that neonatal RVT should be evaluated for thrombophilia conditions. ..
  19. Prochazka M, Krcova V, Kudela M, Slavik L. [Occurrence of gene mutations in factor V Leiden, prothrombin and methylenetetrahydrofolate reductase in patients with pre-eclampsia]. Ceska Gynekol. 2003;68:162-6 pubmed
    ..The prevalence of APC resistance was statistically higher in preeclamptic patients compared to the control group. ..
  20. Canonico M, Alhenc Gelas M, Plu Bureau G, Olié V, Scarabin P. Activated protein C resistance among postmenopausal women using transdermal estrogens: importance of progestogen. Menopause. 2010;17:1122-7 pubmed publisher
    ..These results provide a biological support to epidemiological data regarding the potential thrombogenic effects of norpregnanes. However, these findings need to be confirmed in a randomized trial. ..
  21. Zavala Hernández C, Hernández Zamora E, Martinez Murillo C, Arenas Sordo M, González Orozco A, Reyes Maldonado E. Association of resistance to activated protein with the presence of Leiden and Cambridge Factor V mutations in Mexican patients with primary thrombophilia. Cir Cir. 2010;78:127-32 pubmed
    Leiden and Cambridge factor V coagulation mutations and activated protein C resistance (RaPC) are alterations related with vein and artery thrombosis...
  22. Tan X, Yu Z, Sao J, Chen L, Shen Y, Ding J, et al. Association between in vitro fertilization outcomes and inherited thrombophilias: a meta-analysis. J Assist Reprod Genet. 2016;33:1093-8 pubmed publisher
    ..gene G20210A mutation (PGM), 5,10-methylentetrahydrofolate reductase (MTHFR) C677T, MTHFR (A1298C) and activated protein C resistance (APCR). The main outcome measures included CPR and implantation rate (IR)...
  23. Martinelli I, Battaglioli T, Bucciarelli P, Passamonti S, Mannucci P. Risk factors and recurrence rate of primary deep vein thrombosis of the upper extremities. Circulation. 2004;110:566-70 pubmed
    ..Oral contraceptives increase the risk only when combined with inherited thrombophilia. The recurrence rate of primary upper-extremity DVT is low but tends to be higher in patients with thrombophilia than in those without. ..
  24. Elice F, Fink L, Tricot G, Barlogie B, Zangari M. Acquired resistance to activated protein C (aAPCR) in multiple myeloma is a transitory abnormality associated with an increased risk of venous thromboembolism. Br J Haematol. 2006;134:399-405 pubmed
    Acquired activated protein C resistance (aAPCR), not associated with factor V Leiden, has been described in cancer patients with an increased risk of venous thromboembolism (VTE)...
  25. VanWijk M, Boer K, Berckmans R, Meijers J, van Der Post J, Sturk A, et al. Enhanced coagulation activation in preeclampsia: the role of APC resistance, microparticles and other plasma constituents. Thromb Haemost. 2002;88:415-20 pubmed
    ..In pregnancy and preeclampsia, increased activated protein C resistance occuffed (APC sensitivity ratio: 3.3 +/- 0.8 and 2.5 +/- 0.8, both P <0.001 vs. nonpregnant)...
  26. Kassir R, Debs T, Blanc P, Gugenheim J, Ben Amor I, Boutet C, et al. Complications of bariatric surgery: Presentation and emergency management. Int J Surg. 2016;27:77-81 pubmed publisher
    ..assessment is performed (measurement of antithrombin III and of protein C and protein S, testing for activated protein C resistance)...
  27. Prochazka M, Lubusky M, Slavik L, Hrachovec P, Zielina P, Kudela M, et al. Frequency of selected thrombophilias in women with placental abruption. Aust N Z J Obstet Gynaecol. 2007;47:297-301 pubmed
    ..1%) in the placental abruption group, compared to ten of 196 (5.1%) in the control group (odds ratio 3.0, 95% confidence interval 1.4-6.7). We found that factor V Leiden is a significant risk factor for placental abruption. ..