Research Topics
| decontaminationSummarySummary: The removal of contaminating material, such as radioactive materials, biological materials, or CHEMICAL WARFARE AGENTS, from a person or object. Top Publications
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Publications
Decontamination of the digestive tract and oropharynx in ICU patientsA M G A de Smet
Division of Perioperative and Emergency Care, University Medical Center, Utrecht, The Netherlands
N Engl J Med 360:20-31. 2009Selective digestive tract decontamination (SDD) and selective oropharyngeal decontamination (SOD) are infection-prevention measures used in the treatment of some patients in intensive care, but reported effects on patient outcome are ..
Decontamination of surgical instruments from prions. II. In vivo findings with a model system for testing the removal of scrapie infectivity from steel surfacesKarin Lemmer
P24, Transmissible Spongiform Encephalopathies, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
J Gen Virol 89:348-58. 2008..causing transmissible spongiform encephalopathies (TSEs) to chemical or thermal inactivation requires special decontamination procedures in order to prevent accidental transmission of these pathogens by surgical instruments...
Changing bacterial ecology during a five-year period of selective intestinal decontaminationW Lingnau
Department of Anaesthesia and Intensive Care Medicine, Leopold Franzens University of Innsbruck, Austria
J Hosp Infect 39:195-206. 1998The development of bacterial resistance during selective decontamination of the digestive tract (SDD) is controversial...
Surface decontamination of surgical instruments: an ongoing dilemmaH Murdoch
Centre for Emergency Preparedness and Response (Laboratory A, Health Protection Agency, Porton Down, Salisbury, UK
J Hosp Infect 63:432-8. 2006....
The role of selective decontamination of the digestive tract in acute strokeM Gosney
The Institute of Health Sciences, Building 22, London Road, Reading RG1 5AQ, UK
Age Ageing 35:42-7. 2006..following a stroke, morbidity and mortality is high, with aspiration pneumonia being a common complication...
Randomized controlled trial and meta-analysis of oral decontamination with 2% chlorhexidine solution for the prevention of ventilator-associated pneumoniaHutsaya Tantipong
Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Infect Control Hosp Epidemiol 29:131-6. 2008To determine the effectiveness of oral decontamination with 2% chlorhexidine solution for the prevention of ventilator-associated pneumonia (VAP).
Comparison of different decontamination methods for reagents to detect low concentrations of bacterial 16S DNA by real-time-PCRSven Klaschik
, , Sigmund Freud Strasse 25, D-53105 Bonn, Germany
Mol Biotechnol 22:231-42. 2002..We have tested four different methods of decontamination of PCR reagents in a project aimed at detecting bacterial DNA at low concentrations: deoxyribonuclease (DNAse)..
Reagent decontamination to eliminate false-positives in Escherichia coli qPCRSarah S Silkie
Civil and Environmental Engineering Department, University of California, Berkeley, CA 94720 1710, USA
J Microbiol Methods 72:275-82. 2008..coli and other bacterial DNA. We optimized a DNase I decontamination method to eliminate false-positives in a qPCR assay targeting the uidA gene in E. coli...
Comparison of NaOH-N-acetyl cysteine and sulfuric acid decontamination methods for recovery of mycobacteria from clinical specimensPatricia C A M Buijtels
Medical Centre Rijnmond South, Location Clara, Department of Medical Microbiology, Olympiaweg 350, 3078 HT, Rotterdam, The Netherlands
J Microbiol Methods 62:83-8. 2005We compared the NaOH-N-acetyl cysteine (NaOH-NALC) and the sulfuric acid decontamination procedure in the detection of mycobacteria using the Mycobacteria Growth Indicator Tube (MGIT)...
Impact of digestive and oropharyngeal decontamination on the intestinal microbiota in ICU patientsRobin F Benus
Department of Medical Microbiology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
Intensive Care Med 36:1394-402. 2010Selective digestive microbial decontamination (SDD) is hypothesized to benefit patients in intensive care (ICU) by suppressing Gram-negative potential pathogens from the colon without affecting the anaerobic intestinal microbiota...
Application of a novel decontamination process using gaseous ozoneJohn Moat
University of Manchester School of Medicine, Manchester Royal Infirmary, UK
Can J Microbiol 55:928-33. 2009..Recently, there has been interest in the use of vapor- and gas-based treatments for decontamination of surfaces and rooms...
Bacterial contamination and decontamination of toothbrushes after useAbhishek Mehta
Department of Community Dentistry, Jaipur Dental College, India
N Y State Dent J 73:20-2. 2007..Overnight immersion of a toothbrush in chlorhexidine gluconate (0.2%) was found to be highly effective in preventing such microbial contamination...
Effects of decontamination and implant surface characteristics on re-osseointegration following treatment of peri-implantitisAtes Parlar
Department of Periodontology, Faculty of Dentistry, Gazi University, Ankara, Turkey
Clin Oral Implants Res 20:391-9. 2009..Objectives: To evaluate the effects of various decontamination techniques and implant surface configurations on re-osseointegration of contaminated dental implants.
PCNA-expression of cementoblasts and fibroblasts on the root surface after extraoral rinsing for decontaminationUlrike Ebensberger
Department of Oral Surgery, University of Bonn, Bonn, Germany
Dent Traumatol 18:262-6. 2002..24). Ozonized water, not being isotonic, had no negative effect on periodontal cells remaining on the tooth surface after irrigation for 2 min...
Selective digestive tract decontamination and selective oropharyngeal decontamination and antibiotic resistance in patients in intensive-care units: an open-label, clustered group-randomised, crossover studyAnne Marie G A de Smet
Division of Perioperative and Emergency Care, University Medical Centre Utrecht, Utrecht, The Netherlands
Lancet Infect Dis 11:372-80. 2011Previously, we assessed selective digestive tract decontamination (SDD) and selective oropharyngeal decontamination (SOD) on survival and prevention of bacteraemia in patients in intensive-care units...
Weapons of mass destruction events with contaminated casualties: effective planning for health care facilitiesA G Macintyre
Department of Emergency Medicine, George Washington University Medical Center, Washington, DC, USA
JAMA 283:242-9. 2000..HCF response plan include prompt recognition of the incident, staff and facility protection, patient decontamination and triage, medical therapy, and coordination with external emergency response and public health agencies...
Hypothermia does not increase the risk of infection: a case control studyMarlijn Kamps
Department of Intensive Care, Radboud University Nijmegen Medical Centre PO Box 9101, 6500 HB Nijmegen, The Netherlands
Crit Care 15:R48. 2011..Prolonged hypothermic treatment may further enhance the risk of infection. Selective decontamination of the digestive tract (SDD) reduces the risk of respiratory tract infections...
Microbial contamination of toothbrushes and their decontaminationP Nelson Filho
Department of Pediatric Dentistry, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Brazil
Pediatr Dent 22:381-4. 2000....
Evaluation of five decontamination methods for filtering facepiece respiratorsDennis J Viscusi
National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, Pittsburgh, PA 15236, USA
Ann Occup Hyg 53:815-27. 2009..One possible strategy to mitigate a respirator shortage is to reuse FFRs following a biological decontamination process to render infectious material on the FFR inactive...
Analysis of residual chemicals on filtering facepiece respirators after decontaminationW B Salter
Applied Research Associates, Tyndall Air Force Base, Florida 32403, USA
J Occup Environ Hyg 7:437-45. 2010..be established, many parameters affecting respiratory protection must be measured: biocidal efficacy of the decontamination treatment, filtration performance, pressure drop, fit, and toxicity to the end user post treatment...
Selective decontamination of digestive tract in intensive careHenri A Verbrugh
Lancet 362:2117-8. 2003
An improved method for emergent decontamination of ocular and dermal hydrofluoric acid splashesKjell Soderberg
Medical Service, Avesta Polarit, Torshalla, Sweden
Vet Hum Toxicol 46:216-8. 2004..This report describes the utilization of Hexafluorine--a hypertonic, amphoteric, chelating decontamination solution--in workplaces where water decontamination followed by calcium gluconate inunction failed to prevent ..
Probiotics versus antibiotic decontamination of the digestive tract: infection and mortalityGuy J Oudhuis
Department of Medical Microbiology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands
Intensive Care Med 37:110-7. 2011Selective decontamination of the digestive tract (SDD) has been shown to decrease the infection rate and mortality in intensive care units (ICUs); Lactobacillus plantarum 299/299v plus fibre (LAB) has been used for infection prevention ..
[Caustic injuries of the eye, skin and the gastrointestinal tract]Florian Eyer
Toxikologische Abteilung der II Medizinischen Klinik, Klinikum rechts der Isar Technische Universität München, Munchen
Ther Umsch 66:379-86. 2009..All chemical exposures to the eye require immediate decontamination by copious irrigation with an aqueous solution for at least 15-30 minutes up to two hours in single cases of ..
Development of a test system to evaluate procedures for decontamination of respirators containing viral dropletsEvanly Vo
National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, Pittsburgh, PA 15236, USA
Appl Environ Microbiol 75:7303-9. 2009The aim of this study was to develop a test system to evaluate the effectiveness of procedures for decontamination of respirators contaminated with viral droplets. MS2 coliphage was used as a surrogate for pathogenic viruses...
Investigations of a prion infectivity assay to evaluate methods of decontaminationGuillaume Fichet
STERIS Laboratory, CEA DSV IMETI SEPIA, Fontenay aux Roses, France
J Microbiol Methods 70:511-8. 2007..and various industrial surfaces, but there is currently no standard, accepted model to evaluate surface prion decontamination. In this report, a set of both in vitro and in vivo methods were investigated based on the contamination of ..
Hydrogen peroxide vapour decontamination in an overcrowded tertiary care referral centre: some practical answersJ A Otter
J Hosp Infect 62:384-5. 2006
Oral decontamination with chlorhexidine reduces the incidence of nosocomial pneumoniaIlias I Siempos
Crit Care 11:402; author reply 402. 2007
Decontamination of polymerase chain reaction reagents using DEAE-celluloseS A Glushkov
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russian Federation
Anal Biochem 393:135-7. 2009..from contaminating nucleic acid using DEAE-cellulose and present the analysis of this technique for both decontamination efficiency and an effect on the reagent activity...
Microbial contamination of tooth brushes and their decontaminationS S Bhat
Department of Pedodontics and Preventive Dentistry, Yenepoya Dental College, Mangalore, Karnataka
J Indian Soc Pedod Prev Dent 21:108-12. 2003..Disappearance of growth of microorganisms was seen in Gp I and Gp II and remnants of growth seen in Gp III. It can be concluded that the use of disinfectant is a must for every individual at regular intervals...
Water decontamination of chemical skin/eye splashes: a critical reviewAlan H Hall
Toxicology Consulting and Medical Translating Services, Elk Mountain, Wyoming 82324, USA
Cutan Ocul Toxicol 25:67-83. 2006Skin/eye chemical splashes are a significant workplace problem. Initial water decontamination is usually recommended, but there are few well-conducted experimental animal and human studies of efficacy...
Development of a test system to apply virus-containing particles to filtering facepiece respirators for the evaluation of decontamination proceduresEdward Fisher
EG and G Technical Services, Inc, Pittsburgh, Pennsylvania 15236, USA
Appl Environ Microbiol 75:1500-7. 2009..substrates (coupons) was constructed and validated as part of a method to assess the virucidal efficacy of decontamination procedures for filtering facepiece respirators...
Bone microbial decontamination agents in osseous grafting: an in vitro study with fresh human explantsFernando Verdugo
VA Hospital, Greater Los Angeles, Healthcare System, Los Angeles, CA, USA
J Periodontol 82:863-71. 2011..Establishing a safe prophylactic antimicrobial protocol in bone grafting may enhance osseous volume outcomes. The purpose of this in vitro study is to assess human osteoblast response and safety after explant antimicrobial exposure...
Tuberculosis diagnosis and multidrug resistance testing by direct sputum culture in selective broth without decontamination or centrifugationLouis Grandjean
Departamento de Microbiologia, Facultad de Ciencias, Laboratorios de Investigación y Desarrollo, Universidad Peruana Cayetano Heredia, Lima, Peru
J Clin Microbiol 46:2339-44. 2008Tuberculosis culture usually requires sputum decontamination and centrifugation to prevent cultures from being overgrown by contaminating bacteria and fungi...
Efficient decontamination of zearalenone, the mycotoxin of cereal pathogen, by transgenic yeasts through the expression of a synthetic lactonohydrolase geneNaoko Takahashi-Ando
Laboratory for Remediation Research, Plant Science Center, RIKEN, 1-7-22 Suehiro, Tsurumi, Yokohama, Kanagawa, 230-0045, Japan
Appl Microbiol Biotechnol 67:838-44. 2005..The result suggests that incomplete ZEN detoxification attributed to the action of an endogenous yeast beta-reductase can be overcome by simply increasing the expression of the detoxifying gene...
Alteromonas prolidase for organophosphorus G-agent decontaminationT C Cheng
Environmental Technology Team, US Army Edgewood Research, Development and Engineering Center, Aberdeen, MD 21010, USA
Chem Biol Interact 119:455-62. 1999..sp.JD6.5 with the goal of developing strategies for long-term storage and decontamination have been successfully achieved...
A standardized comparison of commercially available prion decontamination reagents using the Standard Steel-Binding AssayJulie Ann Edgeworth
MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
J Gen Virol 92:718-26. 2011..transfer infectivity to a suitable host, and much research has been performed to achieve effective prion decontamination of metal surfaces...
Colonic sterilization for natural orifice translumenal endoscopic surgery (NOTES) procedures: a comparison of two decontamination protocolsSharon L Bachman
Department of Surgery, University of Missouri, One Hospital Drive, Columbia, MO 65212, USA
Surg Endosc 23:1854-9. 2009..This study aimed to evaluate the effect of two different sterilization protocols on the bacterial counts in the swine colon as preparation for natural orifice translumenal endoscopic surgery (NOTES) surgery...
A method to determine the available UV-C dose for the decontamination of filtering facepiece respiratorsE M Fisher
National Institute for Occupational Safety and Health, National Personal Protective, Technology Laboratory, Pittsburgh, PA 15236, USA
J Appl Microbiol 110:287-95. 2011To develop a method to assess model-specific parameters for ultraviolet-C (UV-C, 254 nm) decontamination of filtering facepiece respirators (FFRs).
Decontamination of prion protein (BSE301V) using a genetically engineered proteaseJ Dickinson
Health Protection Agency, Porton Down, Salisbury, UK
J Hosp Infect 72:65-70. 2009..This study demonstrates the potential for thermostable proteases to be developed as effective inactivation processes for prion agents in healthcare management...
Analysis of hydrofluoric acid penetration and decontamination of the eye by means of time-resolved optical coherence tomographyFelix Spöler
Institute of Semiconductor Electronics, RWTH Aachen University, Sommerfeldstrasse 24, 52074 Aachen, Germany
Burns 34:549-55. 2008So far the study of chemical burns has lacked techniques to define penetration kinetics and the effects of decontamination within biological structures...
Pulsed-light system as a novel food decontamination technology: a reviewN Elmnasser
Laboratoire d Analyse, de Traitement et de Valorisation des Polluants de l Environnement et de Produits Faculte de Pharmacie de Monastir, Rue Avicenne, 5000 Monastir, Tunisie
Can J Microbiol 53:813-21. 2007..It appears to constitute a good alternative or a complement to conventional thermal or chemical decontamination processes...
Cleanability of dental instruments--implications of residual protein and risks from Creutzfeldt-Jakob diseaseJ T Walker
HPA Centre for Emergency Preparedness and Response, Porton Down, Salisbury, SP4 0JG
Br Dent J 203:395-401. 2007....
Improved laboratory safety by decontamination of unstained sputum smears for acid-fast microscopyLuiz Roberto Bigão Giacomelli
Departamento de Analises Clinicas, Universidade Estadual de Maringa, PR, Brazil
J Clin Microbiol 43:4245-8. 2005..7% for 1 min (tube technique) or for 10 min (slide technique) were effective in decontaminating sputum smears and preserved cell morphology and quantitative acid-fast microscopy results...
Comparison of two concentrations of NALC-NaOH for decontamination of sputum for mycobacterial cultureR L Peres
Nucleo de Doencas Infecciosas, Universidade Federal do Espirito Santo, Vitoria, Espirito Santo, Brazil
Int J Tuberc Lung Dis 13:1572-5. 2009..of sodium hydroxide (NaOH) in the N-acetyl-L-cysteine-sodium hydroxide (NALC-NaOH) method for sputum decontamination on smear and culture positivity and the proportion of contaminated cultures: 14% of cultures were ..
Point-of-care controls for nosocomial legionellosis combined with chlorine dioxide potable water decontamination: a two-year survey at a Welsh teaching hospitalI K Hosein
Infection Prevention and Control Department, Cardiff and Vale NHS Trust, University Hospital of Wales, Heath Park, Cardiff CF14 4XW, Wales, UK
J Hosp Infect 61:100-6. 2005....
A pandemic influenza preparedness study: use of energetic methods to decontaminate filtering facepiece respirators contaminated with H1N1 aerosols and dropletsBrian K Heimbuch
Applied Research Associates, Tyndall Air Force Base, 104 Research Road, Panama City, FL 32403, USA
Am J Infect Control 39:e1-9. 2011..The focus of this research effort was on evaluating the ability of microwave-generated steam, warm moist heat, and ultraviolet germicidal irradiation at 254 nm to decontaminate H1N1 influenza virus...
Infectivity of prion protein bound to stainless steel wires: a model for testing decontamination procedures for transmissible spongiform encephalopathiesZheng-Xin Yan
SMP GmbH Pruefen Validieren Forschen, Tubingen, Germany
Infect Control Hosp Epidemiol 25:280-3. 2004..wires contaminated with infectious brain materials as transfer vehicles, and, based on this model, to test decontamination procedures against the infectious prion proteins on the steel wires as a near real situation bioassay...
Selective decontamination of digestive tract in intensive careMohit Sahni
Lancet 362:2119; author reply 2119-20. 2003
Intralaboratory reproducibility of the German test method of prEN ISO 15883-1 for determination of the cleaning efficacy of washer-disinfectors for flexible endoscopesB Zühlsdorf
Technische Hygiene, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 27, 12203 Berlin, Germany
J Hosp Infect 59:286-91. 2005..2 (range: 1.6-3.2) and excellent visible cleanliness of the test pieces. We found that the prEN ISO 15883-1 German test method leads to reproducible and valid results, and is suitable for determining the cleaning efficacy in WDs...
Decontamination of chemical and biological warfare agents with a single multi-functional materialGabi Amitai
McGowan Institute for Regenerative Medicine, University of Pittsburgh, 450 Technology Drive, Pittsburgh, PA 15219, USA
Biomaterials 31:4417-25. 2010..dimethylacrylamide-methacrylate (DMAA-MA) co-polymer backbone that support both chemical and biological agent decontamination. Polyurethanes containing the redox enzymes glucose oxidase and horseradish peroxidase can convert halide ..
Comparisons of protocols for decontamination of environmental ice samples for biological and molecular examinationsS O Rogers
Department of Biological Sciences, Bowling Green State University, Bowling Green, Ohio 43403, USA
Appl Environ Microbiol 70:2540-4. 2004..We report herein a systematic comparative study of several decontamination protocols...
Resistance of transmissible spongiform encephalopathy agents to decontaminationD M Taylor
SEDECON 2000, Edinburgh, UK
Contrib Microbiol 11:136-45. 2004
Effects on instruments of the World Health Organization--recommended protocols for decontamination after possible exposure to transmissible spongiform encephalopathy-contaminated tissueStanley A Brown
United States Food and Drug Administration, Center of Devices and Radiological Health, Office of Science and Technology, Rockville, MD 20850, USA
J Biomed Mater Res B Appl Biomater 72:186-90. 2005..by the World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC) that rigorous decontamination protocols be used on surgical instruments that have been exposed to tissue possibly contaminated with ..
Tackling contamination of the hospital environment by methicillin-resistant Staphylococcus aureus (MRSA): a comparison between conventional terminal cleaning and hydrogen peroxide vapour decontaminationG L French
Department of Infection, King s College London, North Wing, St Thomas Hospital, UK
J Hosp Infect 57:31-7. 2004..by MRSA, and compared the effectiveness of standard cleaning with a new method of hydrogen peroxide vapour decontamination. MRSA contamination, measured by surface swabbing was compared before and after terminal cleaning that ..
Detection of prion after decontamination procedures: comparative study of standard Western blot, filter retention and scrapie-cell assayJ Solassol
, UPR 1142 du CNRS, 141 rue de la Cardonille, 34396 Montpellier Cedex 05, France
J Hosp Infect 57:156-61. 2004..problem because the infectious agent exhibits an unusual resistance to conventional chemical and physical decontamination methods...
The role of selective digestive decontamination for reducing infection in patients undergoing liver transplantation: a systematic review and meta-analysisNasia Safdar
Section of Infectious Diseases, Department of Internal Medicine, University of Wisconsin Medical School, Madison, WI, USA
Liver Transpl 10:817-27. 2004Selective digestive decontamination (SDD) refers to the use of antimicrobials to reduce the burden of aerobic gram-negative bacteria and/or yeast in the intestinal tract to prevent infections caused by these organisms...
Biodegradation of ochratoxin A by Aspergillus section Nigri species isolated from French grapes: a potential means of ochratoxin A decontamination in grape juices and mustsHend Bejaoui
, , Auzeville-Tolozane, Castanet-Tolosan, France
FEMS Microbiol Lett 255:203-8. 2006..After 9 days of incubation, OTalpha had decreased, whereas an unknown compound appeared. A. niger could be the first interesting species for OTA detoxification processes, followed by A. japonicus...
Chemical and biological weapons. Implications for anaesthesia and intensive careS M White
Department of Anaesthesia, Guy's and St Thomas' Hospital Trust, St Thomas' Street, London SE1 9RT, UK
Br J Anaesth 89:306-24. 2002..The specific roles of the anaesthetist and intensivist in treatment are highlighted...
Influence on outcome of ventilator-associated pneumonia in multiple trauma patients with head trauma treated with selected digestive decontaminationMarc Leone
Intensive Care Unit and Trauma Center, Nord Hospital, Marseilles University Hospital System, Marseilles School of Medicine, Marseilles, France
Crit Care Med 30:1741-6. 2002..In multiple trauma, the use of selective digestive decontamination has been reported to decrease morbidity and mortality associated with pneumonia...
Gastrointestinal decontamination of the poisoned patientSpencer Greene
Department of Emergency Medicine, Wright State University Boonshoft School of Medicine, Dayton, OH 45429, USA
Pediatr Emerg Care 24:176-86; quiz 187-9. 2008Gastrointestinal decontamination has been a historically accepted modality in the emergency management of oral intoxicants...
The effect of multiple cycles of contamination, detergent washing, and disinfection on the development of biofilm in endoscope tubingKaren Vickery
Department of Plastic and Reconstructive Surgery, Liverpool Hospital and Surgical Infection Research Group, South Western Clinical School, University of New South Wales, Sydney, Australia
Am J Infect Control 37:470-5. 2009..Biofilm bacteria are firmly attached to one another and to the substrate by exopolysaccharide, making them difficult to remove. We analyzed the effect of 20 wash/contamination cycles on biofilm formation...
Limiting the use of gastrointestinal decontamination does not worsen the outcome from deliberate self-poisoningM Ardagh
Emergency Department, Christchurch Hospital
N Z Med J 114:423-5. 2001..To review the current epidemiology of patients with deliberate self-poisoning presenting to Christchurch Emergency Department, and to compare this with 1996, 1992, and 1989 data...
Relationship between methodological trial quality and the effects of selective digestive decontamination on pneumonia and mortality in critically ill patientsC A van Nieuwenhoven
Department of Internal Medicine, Division of Infectious Diseases and AIDS, University Hospital, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
JAMA 286:335-40. 2001Although meta-analyses of randomized trials have shown that selective digestive decontamination (SDD) prevents nosocomial pneumonia in critically ill patients, the influence of trial quality on the effectiveness of SDD has not been ..
Survival benefit of the full selective digestive decontamination regimenLuciano Silvestri
Unit of Anesthesia and Intensive Care, Department of Emergency, Presidio Ospedaliero di Gorizia, 34170 Gorizia, Italy
J Crit Care 24:474.e7-14. 2009We assessed the impact of the full protocol of selective decontamination of the digestive tract (SDD) using parenteral and enteral antimicrobials on mortality.
Decontamination of multiple casualties who are chemically contaminated: a challenge for acute hospitalsSimon F J Clarke
Emergency Department, Frimley Park NHS Foundation Trust, Portsmouth Road, Frimley, Camberley, Surrey GU16 7UJ, UK
Prehosp Disaster Med 23:175-81. 2008..The risks and potential consequences of this gap in resilience are discussed and a number of possible practical solutions are proposed...
In situ decontamination of medical wastes using oxidative agents: a 16-month study in a polyvalent intensive care unitB Coronel
Intensive Care Unit, Edouard Herriot Hospital, Lyon, Cedex, France
J Hosp Infect 50:207-12. 2002..Aero-contamination of the ward was unchanged. Computer control allowed all events to be tracked. On-site medical waste treatment appears to be an efficient alternative to the usual centralized collection and treatment...
Potential agents of chemical warfare. Worst-case scenario protection and decontamination methodsAngeline A Lazarus
Department of Internal Medicine, National Naval Medical Center, 8901 Wisconsin Ave, Bethesda, MD 20889-5600, USA
Postgrad Med 112:133-40. 2002
Selective decontamination of the digestive tract reduces mortality in critically ill patientsMarcus J Schultz
Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
Crit Care 7:107-10. 2003
Selective decontamination of the digestive tract: cumulating evidence, at last?Marc J M Bonten
Department of Internal Medicine, Division of General Medicine, Infectious Diseases and Geriatrics, Eijkman Winkler Institute for Microbiology, Inflammation and Infectious Diseases, University Medical Centre Utrecht, The Netherlands
Semin Respir Crit Care Med 27:18-22. 2006Selective decontamination of the digestive tract (SDD), an infection-control strategy designed to prevent nosocomial pneumonia in mechanically ventilated patients, has been implemented in numerous studies for more than 2 decades, but its ..
Effect of prion decontamination protocols on nickel-titanium rotary surfacesDavid Sonntag
Department of Operative Dentistry, Philipps Universitat Marburg, Georg Voigt Strasse 3, 35033 Marburg, Germany
J Endod 33:442-6. 2007b>Decontamination of instruments is a prerequisite for their potential reuse but may affect surface integrity. Hence, the effect of prion removal protocols on 7 brands of nickel-titanium files was investigated...
Selective decontamination of the digestive tract reduces bacterial bloodstream infection and mortality in critically ill patients. Systematic review of randomized, controlled trialsL Silvestri
Department of Anaesthesia and Intensive Care, Presidio Ospedaliero, Gorizia, Italy
J Hosp Infect 65:187-203. 2007A systematic review and meta-analysis of randomized controlled trials (RCTs) of selective decontamination of the digestive tract (SDD) was undertaken to evaluate the impact of this procedure on bacterial bloodstream infection and ..
Decontamination of orthodontic bands following size determination and cleaningP E Benson
Department of Oral Health and Development, Institution School of Clinical Dentistry, Claremont Crescent, Sheffield, S10 2TA, UK
J Orthod 34:18-24. 2007..To measure the effectiveness of ultrasonic cleaning for decontaminating orthodontic molar bands following size determination using a quantitative antibody capture assay technique...
Alfalfa seed decontamination in a Salmonella outbreakChristopher J Gill
Oregon Department of Human Services, Portland, Oregon, USA
Emerg Infect Dis 9:474-9. 2003..However, little is known about the effectiveness of decontamination at preventing human disease...
[Nerve gas--guidelines for care of victims of terrorism]Pål Aas
Forsvarets forskningsinstitutt, 2027 Kjeller
Tidsskr Nor Laegeforen 125:731-5. 2005..This involves decontamination of patients, establishment of routines to avoid contamination of hospitals, and the ability to determine if ..
Risks posed by mystery illnessEmma Wilkinson
Nurs Times 102:23-4. 2006..Nurses must be aware of the protocols to follow to ensure their own safety and that of other patients. This article discusses the national advice in dealing with incidents or outbreaks of unusual illness...
Manual methods are suboptimal compared with automated methods for cleaning of single-use biopsy forcepsM J Alfa
Department of Medical Microbiology and Infectious Diseases, St Boniface Research Centre, St Boniface General Hospital, Winnipeg, Manitoba, Canada
Infect Control Hosp Epidemiol 27:841-6. 2006..The objective of this study was to determine the cleaning efficacy of automated narrow-lumen sonic irrigation cleaning, sonication-only cleaning, and manual cleaning for biopsy forceps...
Chemical or biological terrorist attacks: an analysis of the preparedness of hospitals for managing victims affected by chemical or biological weapons of mass destructionRussell L Bennett
Department of Health Policy and Management, School of Public Health, College of Public Service, Jackson State University, Jackson Medical Mall, 350 W Woodrow Wilson Ave, Suite 2301 A, Jackson, Mississippi, USA
Int J Environ Res Public Health 3:67-75. 2006..survey, the availability of functional preparedness plans, specific preparedness education/training, decontamination facilities, surge capacity, pharmaceutical supplies, and laboratory diagnostic capabilities of hospitals were ..
Truth hurts--hard lessons from Australia's largest mass casualty exercise with contaminated patientsNicholas A Edwards
Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Emerg Med Australas 18:185-95. 2006..by the exercise, which we believe have enormous implications for the development of hospital chemical, biological or radiological plans and the likelihood of their success--hospital security, crowd control and decontamination.
A laboratory evaluation of the decontamination properties of microfibre clothsG Moore
School of Applied Sciences, University of Wales Institute, Cardiff, UK
J Hosp Infect 64:379-85. 2006..Different makes of microfibre cloths have different characteristics, and the name 'microfibre' should not imply superior cleaning efficacy...
Safety evaluation of single-use medical devices after submission to simulated reutilization cyclesMônica Valero Da Silva
Fundacao Universidade de Brasilia, Faculdade de Ciencias da Saude, Departamento de Farmacia, Campus Universitário Asa Norte, CEP 70910 900, Brazilia, DF, Brazil
J AOAC Int 88:823-9. 2005..Microbial counts as high as 10(3) CFU were evident even after the 10th reprocessing cycle, besides scratched and damaged surfaces observed by SEM. Risk-benefit viewpoints are discussed...
Medical resources and requirements for responding to radiological terrorismFred A Mettler
Department of Radiology, New Mexico Federal Regional Medical Center, 1501 San Pedro Blvd, Albuquerque, NM 87108, USA
Health Phys 89:488-93. 2005..Although the requirements for medical management are clear, the available resources have not been applied in a manner that results in adequate preparedness for radiological events...
[In-hospital management of victims of chemical weapons of mass destruction]Alessandro Barelli
Centro Antiveleni, Servizio di Tossicologia Clinica, Istituto di Anestesiologia e Rianimazione, Universita Cattolica del Sacro Cuore, Largo A Gemelli 8, 00161 Rome, Italy
Ann Ist Super Sanita 41:93-101. 2005..This review is designed to familiarize readers with the concepts, terminology and key operational considerations that affect the in-hospital management of incidents by chemical weapons...
Clinical care in the "Hot Zone"M Byers
Academic Department of Military Emergency Medicine, Royal Centre for Defence Medicine, Selly Oak Hospital, Birmingham, UK
Emerg Med J 25:108-12. 2008..This article discusses the background to the current threat and suggests that, where survivors are present in the "Hot Zone", medical care should be started there to minimise delay and maximise the chances of survival...
Toxicological aspects of preparedness and aftercare for chemical-incidentsMichael Schwenk
Landesgesundheitsamt, Wiederholdstr, 15, 70174 Stuttgart, Germany
Toxicology 214:232-48. 2005..consult public health services with regard to toxicosurveillance and advice hospitals regarding antidotes, decontamination procedures and shelters...
Unmasking procedures following a chemical attack: a critical review with recommendationsDavid B Rosenberg
Battalion Surgeon, 5th Battalion, 10th Marines, 2nd Marine Division Camp, Lejeune, NC 28542, USA
Mil Med 170:599-601. 2005..Easy to implement recommendations are made, both to prevent lethal exposures and to better treat toxicity should prevention fail...
Rapid recontamination with MRSA of the environment of an intensive care unit after decontamination with hydrogen peroxide vapourK J Hardy
West Midlands Public Health Laboratory, Health Protection Agency, Heartlands Hospital, Bordesley Green East, Birmingham, UK
J Hosp Infect 66:360-8. 2007..level of environmental contamination with MRSA, assess the effectiveness of hydrogen peroxide vapour (HPV) decontamination and determine the rate of environmental recontamination. MRSA was isolated from 11...
Civilian exposure to toxic agents: emergency medical responseDavid Baker
, , 75574 Paris 15, France
Prehospital Disaster Med 19:174-8. 2004..Within an organized and protected perimeter, triage and decontamination (if the agent is persistent) can proceed while emergency medical care is provided at the same time...
Mass casualty management for radiological and nuclear incidentsS A Bland
Defence Medical Services, Royal London Hospital, London E1 1BB
J R Army Med Corps 150:27-34. 2004..From these findings, appropriate management based upon the needs and available resources can be planned. This includes triage for surgery and the use of the expectant (T4) triage category...
[Preventive strategies for nosocomial pneumonia]Kazui Soma
Department of Emergency and Critical Care Medicine, Kitasato Univerisity, School of Medicine, Kanagawa, Japan
Nippon Geka Gakkai Zasshi 105:716-9. 2004..Useful preventative strategies include subglottic suctioning of pooled secretions just above the endotracheal tube cuff and oral care because of the pathogenesis of VAP...
How would you respond to a chemical release?Carolin M Reilly
Central Maine Medical Center, Lewiston, USA
Nursing 33:36-42; quiz 43. 2003..Whether an industrial accident or an act of terrorism, a chemical release can spell disaster. Here you'll learn to respond appropriately, depending on the type and form of chemical involved...
Amazing terrorism tool: new foam could revolutionize deconJeff Lindsey
Estero (Fla.) Fire Rescue, USA
JEMS 28:84, 86. 2003
The Army chemical/biological SMART (SMART-CB) team: the nurse's roleKenny Barajas
Walter Reed Army Medical Center, Walter Reed Station, Washington, DC 20012, USA
Crit Care Nurs Clin North Am 15:257-64. 2003..Early recognition, reporting, decontamination, self-protection, prophylaxis, and treatment are imperative...
In vitro modeling of dental water line contamination and decontaminationD A Spratt
Division of Microbial Diseases, Eastman Dental Institute for Oral Health Care Sciences, UCL, London, UK
FEMS Microbiol Lett 235:363-7. 2004..The aim of this study was to use an in vitro DUWL to model microbial contamination and evaluate the decontamination efficacy of tetraacetylethylenediamine (TAED) solutions...
Rapid inactivation of vaccinia virus in suspension and dried on surfacesA Ferrier
, , Grenoble, France
J Hosp Infect 57:73-9. 2004..Safe decontamination procedures will have to be in place in order to limit the spread of the disease...
The problem of secondary contamination following chemical agent releaseDavid Baker
SAMU 75, Hopital Necker - Enfants Malades, Paris, France
Crit Care 9:323-4. 2005
Chemical weapon functional exercise--Cincinnati: observations and lessons learned from a "typical medium-sized" city's response to simulated terrorism utilizing Weapons of Mass DestructionDenis J FitzGerald
Department of Emergency Medicine, University Hospital, Cincinnati, OH 45267 0769, USA
Public Health Rep 118:205-14. 2003..day that have widespread applicability to health care delivery systems nationwide, especially in the areas of decontamination, triage, on-scene medical care, and victim transportation...
Operation Castle Cascade: managing multiple casualties from a simulated chemical weapons attackDavid Siegel
Department of Emergency Medicine, Madigan Army Medical Center, Tacoma, WA 98431, USA
Mil Med 168:351-4. 2003..Issues relating to on-site chemical identification, triage, decontamination, treatment, casualty collection, and transportation of casualties are addressed in this article.
Inadequacy of manual cleaning for reprocessing single-use, triple-lumen sphinctertomes: simulated-use testing comparing manual with automated cleaning methodsMichelle J Alfa
Department of Clinical Laboratory Science, Wayne State University, Detroit, Michigan, USA
Am J Infect Control 31:193-207. 2003..Our data validate the efficacy of reprocessing sphinctertomes once with SI-Auto retro-flush cleaning followed by 2 hours of ethylene oxide sterilization...
An unusual incident: breached 22Na sealed sourceL E Porter
Washington State University, Pullman, WA 99164, USA
Health Phys 86:S38-41. 2004..Safety Office were severely taxed during both the immediate reaction and the subsequent several months of decontamination prior to release of the laboratory for unrestricted use of radioactive materials once again...
Chemical and biological terrorism preparedness for staff development specialistsTener Goodwin Veenema
University of Rochester School of Nursing, NY, USA
J Nurses Staff Dev 19:218-25; quiz 226-7. 2003....
Research Grants
- Processing of Materials for Improved BiocompatibilityMichael Matthews; Fiscal Year: 2004..used in biomedical devices such as prostheses and implants by providing a higher level of cleanliness and decontamination, while simultaneously providing sterilization...
- Nonheme Diiron Centers and the Biological Oxidation of HydrocarbonsSTEPHEN LIPPARD; Fiscal Year: 2009..of the molecular mechanisms of O2 activation and substrate hydroxylation provided by this research will advance novel strategies for environmental decontamination and the development of catalysts to convert methane to methanol.
- Nonheme Diiron Centers and the Biological Oxidation of HydrocarbonsSTEPHEN LIPPARD; Fiscal Year: 2009..of the molecular mechanisms of O2 activation and substrate hydroxylation provided by this research will advance novel strategies for environmental decontamination and the development of catalysts to convert methane to methanol.
- Nonheme Diiron Centers and the Biological Oxidation of HydrocarbonsSTEPHEN LIPPARD; Fiscal Year: 2007..molecular mechanisms of 62 activation and substrate hydroxylation provided by this research will advance novel strategies for environmental decontamination and the development of catalysts to convert methane to methanol.
- Novel Organophosphorous Hydrolases for DecontaminationAndrew Mesecar; Fiscal Year: 2007..the focus of intense research efforts aimed at developing these enzymes into products for enzyme- based decontamination. Unfortunately, the enzymes currently in development lack many of the desired properties such as solution ..
- Testing Interventions to Human-Generated Occupational Airborne InfectionsEdward A Nardell; Fiscal Year: 2010..We will test both a conventional HEPA filter unit and novel low-maintenance electrostatic air decontamination technology developed for use in outer space...
- Testing Interventions to Human-Generated Occupational Airborne InfectionsEdward A Nardell; Fiscal Year: 2010..We will test both a conventional HEPA filter unit and novel low-maintenance electrostatic air decontamination technology developed for use in outer space...
- Nonheme Diiron Centers and the Biological Oxidation of HydrocarbonsStephen J Lippard; Fiscal Year: 2010..The ability of these hydrocarbon-consuming "superbugs" to degrade chlorinated hydrocarbons has led to their application in the bioremediation of industrial wastewater, decontamination of seawater, and removal of soil pollutants.
- Data Mining Assisted Discovery of Novel OrganophosphorouRobert Turner; Fiscal Year: 2005..become the focus of intense research efforts aimed at developing these enzymes into products for enzyme-based decontamination. However, currently available enzymes lack many of the desired properties such as solution solubility, ..
- ORAL CARE INTERVENTION IN MECHANICALLY VENTILATED ADULTSCindy L Munro; Fiscal Year: 2010..Pre-intubation oral decontamination could reduce risk of VAP and its associated morbidity and mortality...
- Nisin as a decontaminant for B. anthracis spores on human skinKenneth Alibek; Fiscal Year: 2007..Many of the decontamination regimens under investigation are too harsh for use on skin...
- SPORE PEPTIDOGLYCAN SYNTHESIS IN BACILLUS SUBTILISDAVID POPHAM; Fiscal Year: 2002..Knowledge of principles of endospore resistance properties, dormancy,and longevity may contribute to better decontamination methods and methods for storage and transport of drugs and vaccines...
- High Throughput Bioengineering of Detoxification EnzymesMargaret Bradley; Fiscal Year: 2003..optimal conditions of assay and other substrates (by us or by collaborators), and iii) finally adding adaptors and modifications to these enzymes for use as biosensors or as a detoxification and/or decontamination tools.
- Biofilm Formation by Listeria monocytogenesKATHERINE LEMON; Fiscal Year: 2007..This makes decontamination of biofilm-coated surfaces particularly difficult...
- Low Temp Decontamination/Sterilize/Dental HandpiecesMohamed Labib; Fiscal Year: 2005..This development is expected to reduce DH costs for the dental practice, standardize DH cleaning and lubrication steps, and decrease exposure of dental workers to microbial contamination compared to the current practice. ..
- A Randomized Clinical Trial to Prevent Recurrent CA-MRASA InfectionLoren Miller; Fiscal Year: 2007..Others suggest environmental decontamination to help control recurrences and transmission within households...
- Communicore Animal Facility (CAF) Renovation Phase III Part IIAUGUST BATTLES; Fiscal Year: 2007..will be reconfigured to provide an exit for potentially infectious caging and materials and their efficient decontamination. Additionally, the route of sterile caging into the ABSL3 from the new CAF Annex cage wash will be shortened ..
- Alcohol Intoxication and Postburn Intestinal ImmunityMashkoor Choudhry; Fiscal Year: 2009..In Specific Aim 2 studies using approaches of selective decontamination of intestine with antibiotics prior to EtOH intoxication and burn injury will determine whether intestinal ..
- Alcohol Intoxication and Postburn Intestinal ImmunityMashkoor Choudhry; Fiscal Year: 2007..In Specific Aim 2 studies using approaches of selective decontamination of intestine with antibiotics prior to EtOH intoxication and burn injury will determine whether intestinal ..
- Alcohol Intoxication and Postburn Intestinal ImmunityMashkoor Choudhry; Fiscal Year: 2009..In Specific Aim 2 studies using approaches of selective decontamination of intestine with antibiotics prior to EtOH intoxication and burn injury will determine whether intestinal ..
