- Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice
R D Hautamaki
Department of Internal Medicine, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, MO 63110, USA
Science 277:2002-4. 1997
..characteristic of pulmonary emphysema, macrophage elastase-deficient (MME-/-) mice were subjected to cigarette smoke. In contrast to wild-type mice, MME-/- mice did not have increased numbers of macrophages in their lungs and did ..
- Modulation of microRNA expression by budesonide, phenethyl isothiocyanate and cigarette smoke in mouse liver and lung
Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
Carcinogenesis 31:894-901. 2010
..to evaluate the modulation of mRNA expression as related to exposure of neonatal mice to environmental cigarette smoke (ECS) and to treatment with chemopreventive agents...
- IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice
Fernando M Botelho
Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Canada
PLoS ONE 6:e28457. 2011
..Despite this, the cellular and molecular mechanisms that contribute to COPD pathogenesis are still poorly understood...
- Respiratory health effects of air pollution: update on biomass smoke and traffic pollution
Robert J Laumbach
Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School and Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
J Allergy Clin Immunol 129:3-11; quiz 12-3. 2012
..Physicians can help to reduce the risk of adverse respiratory effects of exposure to biomass and traffic air pollutants by promoting awareness and supporting individual and community-level interventions...
- Tobacco smoke: involvement of reactive oxygen species and stable free radicals in mechanisms of oxidative damage, carcinogenesis and synergistic effects with other respirable particles
Department of Chemistry, Free Radical Research Group, University of Athens, University Campus Zografou, 15784 Athens, Greece
Int J Environ Res Public Health 6:445-62. 2009
Tobacco smoke contains many toxic, carcinogenic and mutagenic chemicals, as well as stable and unstable free radicals and reactive oxygen species (ROS) in the particulate and the gas phase with the potential for biological oxidative ..
- Comparison of the cytotoxic potential of cigarette smoke and electronic cigarette vapour extract on cultured myocardial cells
Konstantinos E Farsalinos
Onassis Cardiac Surgery Center, Sygrou 356, Kallithea 17674, Greece
Int J Environ Res Public Health 10:5146-62. 2013
..Smoking is an important risk factor for cardiovascular disease and cigarette smoke (CS) has well-established cytotoxic effects on myocardial cells...
- Epithelial to mesenchymal transition is increased in patients with COPD and induced by cigarette smoke
Clinical research unit UIC, University General Hospital Consortium, Valencia, Spain
Thorax 68:410-20. 2013
..This study examines the EMT process in human bronchial epithelial cells (HBECs) from non-smokers, smokers and patients with COPD as well as the in vitro effect of cigarette smoke extract (CSE) on EMT.
- Cytotoxicity evaluation of electronic cigarette vapor extract on cultured mammalian fibroblasts (ClearStream-LIFE): comparison with tobacco cigarette smoke extract
Abich srl, biological and chemical toxicology research laboratory, Verbania VB, Italy
Inhal Toxicol 25:354-61. 2013
..Electronic cigarettes (ECs) are used as alternatives to smoking; however, data on their cytotoxic potential are scarce...
- Cigarette smoke induces oxidative stress and apoptosis in normal term fetal membranes
Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Ave NE, Atlanta, GA 30322, USA
Placenta 32:317-22. 2011
..We hypothesized that exposure of fetal membranes to cigarette smoke extracts might induce oxidative stress (OS) and fetal membrane apoptosis, culminating in an alternate pathway to ..
- Risk of COPD from exposure to biomass smoke: a metaanalysis
Guangzhou Institute of Respiratory Diseases, State Key Laboratory of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical University, 151 Yanjiang Rd, Guangzhou, Guangdong, 510120, China
Chest 138:20-31. 2010
Although many studies have suggested that biomass smoke is a risk factor for COPD, the relationship between the two has not been firmly established...
- Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent
University of Orleans and Centre National de la Recherche Scientifique UMR6218, Molecular Immunology and Embryology, France
J Immunol 180:1169-78. 2008
Acute cigarette smoke exposure of the airways (two cigarettes twice daily for three days) induces acute inflammation in mice. In this study, we show that airway inflammation is dependent on Toll-like receptor 4 and IL-1R1 signaling...
- Woodsmoke health effects: a review
Luke P Naeher
Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, Georgia, USA
Inhal Toxicol 19:67-106. 2007
..we examine several topics: the chemical and physical nature of woodsmoke; the exposures and epidemiology of smoke from wildland fires and agricultural burning, and related controlled human laboratory exposures to biomass smoke; ..
- Peat bog wildfire smoke exposure in rural North Carolina is associated with cardiopulmonary emergency department visits assessed through syndromic surveillance
Ana G Rappold
Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
Environ Health Perspect 119:1415-20. 2011
..Although the association of mortality and morbidity with exposure to urban air pollution is well established, the health effects associated with exposure to wildfire emissions are less well understood...
- Intervention to lower household wood smoke exposure in Guatemala reduces ST-segment depression on electrocardiograms
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
Environ Health Perspect 119:1562-8. 2011
..RESPIRE (Randomized Exposure Study of Pollution Indoors and Respiratory Effects) was a randomized trial of a chimney woodstove that reduces wood smoke exposure.
- Smoke constituent exposure and stage of change in black and white women cigarette smokers
Ohio State University, College of Nursing, Columbus 43210, USA
Addict Behav 24:115-20. 1999
Differences in smoke constituent exposure by ethnicity and menthol preference and differences in decisional balance and habit strength by stage of change, ethnicity, and menthol preference were examined in this 2-factor study design...
- Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration
Lucy A Clunes
Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
FASEB J 26:533-45. 2012
Cigarette smoke (CS) exposure induces mucus obstruction and the development of chronic bronchitis (CB)...
- IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke
Department of Genetics, Louisiana State University Health Science Center, New Orleans, Louisiana, United States of America
PLoS ONE 6:e20333. 2011
..Here we show that cigarette smoke is a selective adjuvant that augments in vitro and in vivo Th17, but not Th1, cell differentiation via the aryl ..
- Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate
Thoracic Oncology Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
Oncogene 29:3650-64. 2010
..In this study, we established an in vitro system to examine epigenomic effects of cigarette smoke in respiratory epithelia...
- An air filter intervention study of endothelial function among healthy adults in a woodsmoke-impacted community
Ryan W Allen
Simon Fraser University, Faculty of Health Sciences, 8888 University Drive, Burnaby, British Columbia V5A 1S6, Canada
Am J Respir Crit Care Med 183:1222-30. 2011
..Particulate air pollution is associated with cardiovascular morbidity. One hypothesized mechanism involves oxidative stress, systemic inflammation, and endothelial dysfunction...
- Extrapulmonary manifestations of chronic obstructive pulmonary disease in a mouse model of chronic cigarette smoke exposure
Harry R Gosker
Department of Respiratory Medicine, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
Am J Respir Cell Mol Biol 40:710-6. 2009
..Mice were exposed to cigarette smoke or control air for 6 months...
- Alpha1-antitrypsin suppresses TNF-alpha and MMP-12 production by cigarette smoke-stimulated macrophages
Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5 Canada
Am J Respir Cell Mol Biol 37:144-51. 2007
We have previously observed that mice exposed to cigarette smoke and treated with exogenous alpha(1)-antitrypsin (A1AT) were protected against the development of emphysema and against smoke-induced increases in serum TNF-alpha...
- The role of ChemR23 in the induction and resolution of cigarette smoke-induced inflammation
Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
J Immunol 186:5457-67. 2011
Chronic obstructive pulmonary disease is mainly triggered by cigarette smoke (CS) and progresses even after smoking cessation...
- Cigarette smoke extract induces prolonged endoplasmic reticulum stress and autophagic cell death in human umbilical vein endothelial cells
Division of Experimental Pathophysiology and Immunology, Laboratory of Autoimmunity, Biocenter, Innsbruck Medical University, Innsbruck, Austria
Cardiovasc Res 92:141-8. 2011
Consumption of cigarette smoke (CS) is a well-known risk factor for early atherosclerosis; yet, the underlying mechanisms of smoking-associated atherosclerosis are poorly understood...
- Evaluation of the potential effects of ingredients added to cigarettes. Part 2: chemical composition of mainstream smoke
INBIFO Institut für biologische Forschung, Fuggerstr 3, D 51149, Koln, Germany
Food Chem Toxicol 40:93-104. 2002
Cigarette mainstream smoke from blended research cigarettes with and without the addition of ingredients was analyzed for its chemical composition...
- Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 294:H2721-35. 2008
..The present study was designed to elucidate the effects of resveratrol on cigarette smoke-induced vascular oxidative stress and inflammation, which is a clinically highly relevant model of accelerated ..
- Differential protease, innate immunity, and NF-kappaB induction profiles during lung inflammation induced by subchronic cigarette smoke exposure in mice
Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Parkville, VIC 3050, Australia
Am J Physiol Lung Cell Mol Physiol 290:L931-45. 2006
Cigarette smoke exposure is a major determinant of adverse lung health, but the molecular processes underlying its effects on inflammation and immunity remain poorly understood...
- Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice
Thomas E Sussan
Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 106:250-5. 2009
..disease (COPD), which comprises emphysema and chronic bronchitis resulting from prolonged exposure to cigarette smoke (CS), is a major public health burden with no effective treatment...
- Tobacco smoke exposure is associated with the metabolic syndrome in adolescents
American Academy of Pediatrics Center for Child Health Research, Rochester, NY, USA
Circulation 112:862-9. 2005
..Tobacco smoke potentially contributes to insulin resistance in this syndrome...
- Patterns of p53 G-->T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke
International Agency for Research on Cancer WHO, 150 cours Albert Thomas, 69372 Lyon Cedex, France
Carcinogenesis 22:367-74. 2001
..Our data reinforce the notion that p53 mutations in lung cancers can be attributed to direct DNA damage from cigarette smoke carcinogens rather than to selection of pre-existing endogenous mutations.
- Matrix metalloproteinases activity in COPD associated with wood smoke
Department of Molecular Biology, Instituto Nacional de Enfermedades Respiratorias, Calzada de Tlalpan 4502, CP 14080, Mexico, D F, Mexico
Chest 125:466-72. 2004
Wood smoke (WS) exposure causes COPD with respiratory alterations that are similar to those described for COPD associated with tobacco smoke (TS)...
- Cigarette smoke-related hydroquinone dysregulates MCP-1, VEGF and PEDF expression in retinal pigment epithelium in vitro and in vivo
Department of Ophthalmology, Miller School of Medicine, Bascom Palmer Eye Institute, University of Miami, Miami, Florida, United States of America
PLoS ONE 6:e16722. 2011
..We also evaluated the effects of hydroquinone (HQ), a major pro-oxidant in cigarette smoke on MCP-1, VEGF and PEDF expression in cultured ARPE-19 cells and RPE/choroids from C57BL/6 mice.
- The role of matrix metalloproteinase-9 in cigarette smoke-induced emphysema
Jeffrey J Atkinson
Washington University School of Medicine, St Louis, MO 63110, USA
Am J Respir Crit Care Med 183:876-84. 2011
..Mouse models have demonstrated that excess MMP-9 production can result in permanent alveolar destruction...
- Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes
Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19147, USA
Proc Natl Acad Sci U S A 110:11115-20. 2013
Smoking is a major risk factor for osteoporosis and fracture, but the mechanism through which smoke causes bone loss remains unclear...
- Matrix proteins from smoke-exposed fibroblasts are pro-proliferative
David I Krimmer
Woolcock Institute of Medical Research Cell Biology, Sydney, New South Wales, Australia
Am J Respir Cell Mol Biol 46:34-9. 2012
..We investigated the role of cigarette smoke in altering the ECM deposited from human lung fibroblasts...
- Lung carcinogenesis by tobacco smoke
Stephen S Hecht
Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
Int J Cancer 131:2724-32. 2012
Cigarette smoke is a complex mixture of chemicals including multiple genotoxic lung carcinogens...
- Network meta-analysis to evaluate the effectiveness of interventions to increase the uptake of smoke alarms
Nicola J Cooper
Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, United Kingdom
Epidemiol Rev 34:32-45. 2012
..to simultaneously evaluate the effectiveness of interventions to increase the prevalence of functioning smoke alarms in households with children...
- Induction of the unfolded protein response by cigarette smoke is primarily an activating transcription factor 4-C/EBP homologous protein mediated process
Department of Medicine, Divisions of Molecular and Pulmonary Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Int J Chron Obstruct Pulmon Dis 6:309-19. 2011
Cigarette smoke is the major risk factor associated with the development of chronic obstructive pulmonary disease (COPD)...
- Vapor, dust, and smoke exposure in relation to adult-onset asthma and chronic respiratory symptoms: the Singapore Chinese Health Study
Tricia D LeVan
Arizona Respiratory Center, University of Arizona, Tucson, AZ, USA
Am J Epidemiol 163:1118-28. 2006
..These data support the role of occupational exposures in the etiology of respiratory illness in a population-based cohort in Singapore with a low prevalence of atopic illness...
- Effects on airways of short-term exposure to two kinds of wood smoke in a chamber study of healthy humans
Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital and Academy, University of Gothenburg, Gothenburg, Sweden
Inhal Toxicol 24:47-59. 2012
..Airway inflammation may be involved in the mechanism also for cardiovascular disease. Wood smoke is a significant contributor to air pollution, with complex and varying composition...
- Methylation of Wnt7a is modulated by DNMT1 and cigarette smoke condensate in non-small cell lung cancer
Meredith A Tennis
Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States of America
PLoS ONE 7:e32921. 2012
..Restoration of Wnt7a expression through demethylation could be an important therapeutic approach in the treatment of NSCLC...
- Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants
Daniel N Willis
Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut, USA
FASEB J 25:4434-44. 2011
..It is highly controversial whether menthol in cigarette smoke exerts pharmacological actions affecting smoking behavior...
- Cigarette smoke promotes dendritic cell accumulation in COPD; a Lung Tissue Research Consortium study
The Thoracic Diseases Research Unit, Division of Pulmonary Critical Care, Department of Internal Medicine, the Clinical Immunology and Immunotherapeutics Program, Mayo Clinic and Foundation, Rochester, Minnesota, 55905, USA
Respir Res 11:45. 2010
..Although evident that cigarette smoke, the primary cause of COPD, significantly influences dendritic cell functions, little is known about the roles of ..
- Cigarette smoke extract modulates human beta-defensin-2 and interleukin-8 expression in human gingival epithelial cells
Department of Periodontology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand
J Periodontal Res 44:557-64. 2009
..Their responses to stimuli are critical in maintaining periodontal homeostasis. The aim of this study was to investigate the modulating effect of cigarette smoke extract (CSE) on the innate immune responses of HGECs.
- Cigarette smoke condensate exposure delays follicular development and function in a stage-dependent manner
Jean Clair Sadeu
Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
Fertil Steril 95:2410-7. 2011
To determine the effects of cigarette smoke condensate (CSC) on follicular development and function from the early preantral stage through ovulation.
- Oxidative stress, inflammation, and DNA damage in rats after intratracheal instillation or oral exposure to ambient air and wood smoke particulate matter
Pernille Høgh Danielsen
Section of Environmental Health, Department of Public Health, University of Copenhagen, DK 1014 Copenhagen, Denmark
Toxicol Sci 118:574-85. 2010
..Exposure occurs through inhalation or ingestion after deposition of wood smoke particulate matter (WSPM) on crops and food...
- Genotoxicity of 10 cigarette smoke condensates in four test systems: comparisons between assays and condensates
David M DeMarini
Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Mutat Res 650:15-29. 2008
The particulate fraction of cigarette smoke, cigarette smoke condensate (CSC), is genotoxic in many short-term in vitro tests and is carcinogenic in rodents...
- Exposure to cigarette smoke inhibits the pulmonary T-cell response to influenza virus and Mycobacterium tuberculosis
Center for Pulmonary and Infectious Disease Control, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
Infect Immun 79:229-37. 2011
..Mice were left unexposed or were exposed to cigarette smoke and then infected with Mycobacterium tuberculosis by aerosol or influenza A by intranasal infection...
- Reactivity of mouse alveolar macrophages to cigarette smoke is strain dependent
Dept of Physiopathology and Experimental Medicine, Univ of Siena, Italy
Am J Physiol Lung Cell Mol Physiol 298:L704-13. 2010
Cigarette smoke (CS) is a main risk factor in chronic obstructive pulmonary disease (COPD), but only 20% of smokers develop COPD, suggesting genetic predisposition...
- Cigarette smoke--an aging accelerator?
Vascular Biology Group, Division Experimental Pathophysiology and Immunology, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria
Exp Gerontol 42:160-5. 2007
..In this review, we make an attempt to ascribe many of the deleterious effects of smoking on human health to a general principle, namely the acceleration of aging processes by cigarette smoke chemicals.
- An overview of the effects of tobacco ingredients on smoke chemistry and toxicity
Richard R Baker
British American Tobacco, Research and Development Centre, Regent s Park Road, Southampton SO15 8TL, UK
Food Chem Toxicol 42:S53-83. 2004
..an overview of a series of studies designed to assess the influence of 482 tobacco ingredients on cigarette smoke chemistry and toxicity...
- SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol
Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY 14642, USA
Biochem Biophys Res Commun 393:66-72. 2010
..Cigarette smoke (CS)-mediated oxidative stress is implicated in endothelial dysfunction...
- Indoor air pollution from biomass fuel smoke is a major health concern in the developing world
Duncan G Fullerton
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
Trans R Soc Trop Med Hyg 102:843-51. 2008
..The mechanisms behind these associations are not fully understood. This review summarises the available information on biomass fuel use and health, highlighting the current gaps in knowledge...
- Household air pollution from coal and biomass fuels in China: measurements, health impacts, and interventions
Junfeng Jim Zhang
School of Public Health, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
Environ Health Perspect 115:848-55. 2007
..Our objective in this review was to help elucidate the extent of this indoor air pollution health hazard...
- Polycyclic aromatic hydrocarbons, carbon monoxide, "tar", and nicotine in the mainstream smoke aerosol of the narghile water pipe
Aerosol Research Laboratory, Department of Mechanical Engineering, American University of Beirut, PO Box 11 0236, Riad El Solh, Beirut, Lebanon
Food Chem Toxicol 43:655-61. 2005
..94 mg nicotine, 802 mg "tar", 145 mg CO, and relative to the smoke of a single cigarette, greater quantities of chrysene, phenanthrene, and fluoranthene...
- Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents
Center of Excellence for the Study of Inflammation, University of Ferrara, Ferrara, Italy
J Clin Invest 118:2574-82. 2008
Cigarette smoke (CS) inhalation causes an early inflammatory response in rodent airways by stimulating capsaicin-sensitive sensory neurons that express transient receptor potential cation channel, subfamily V, member 1 (TRPV1) through an ..
- Metals in cigarette smoke
Vascular Biology Group, Division of Experimental Pathophysiology and Immunology, Innsbruck Medical University, Austria
IUBMB Life 57:805-9. 2005
..The metal content of tobacco plants, smoke, the circulation, and various organs is discussed...
- Personal child and mother carbon monoxide exposures and kitchen levels: methods and results from a randomized trial of woodfired chimney cookstoves in Guatemala (RESPIRE)
Kirk R Smith
Environmental Health Sciences, School of Public Health, University of California, Berkeley, California 94720 7360, USA
J Expo Sci Environ Epidemiol 20:406-16. 2010
- The relationship of respiratory and cardiovascular hospital admissions to the southern California wildfires of 2003
R J Delfino
Epidemiology Department, School of Medicine, University of California Irvine, 100 Theory Drive, Irvine, CA 92617 7555, USA
Occup Environ Med 66:189-97. 2009
..The relationship of cardiorespiratory hospital admissions (n = 40 856) to wildfire-related particulate matter (PM(2.5)) during catastrophic wildfires in southern California in October 2003 was evaluated...
- Oxidative stress, DNA damage, and inflammation induced by ambient air and wood smoke particulate matter in human A549 and THP-1 cell lines
Pernille Høgh Danielsen
Section of Environmental Health, Department of Public Health, University of Copenhagen, Denmark
Chem Res Toxicol 24:168-84. 2011
..of ambient air PM, especially related to traffic, is well advanced, whereas the toxicology of wood smoke PM (WSPM) is poorly assessed...
- Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD
Jae Woong Hwang
Department of Environmental Medicine, University of Rochester Medical Center, NY, USA
Arch Biochem Biophys 500:203-9. 2010
..Cigarette smoke (CS)-mediated oxidative stress induces cytotoxic responses in lung cells...
- Cigarette smoke induces C/EBP-β-mediated activation of miR-31 in normal human respiratory epithelia and lung cancer cells
Thoracic Oncology Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
PLoS ONE 5:e13764. 2010
..The present study was undertaken to examine expression and function of miRNAs induced by cigarette smoke condensate (CSC) in normal human respiratory epithelia and lung cancer cells.
- Autophagic proteins regulate cigarette smoke-induced apoptosis: protective role of heme oxygenase-1
Hong Pyo Kim
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, MUH 628NW, Pittsburgh, Pennsylvania, USA
Autophagy 4:887-95. 2008
Cigarette smoke-induced cell death contributes to the pathogenesis of chronic obstructive pulmonary disease, though the relative roles of apoptosis and autophagy remain unclear...
- Lipid-soluble components in cigarette smoke induce mitochondrial production of reactive oxygen species in lung epithelial cells
Marco van der Toorn
Department of Pathology and Medical Biology, Laboratory of Allergology and Pulmonary Diseases, University Medical Center Groningen, University of Groningen, The
Am J Physiol Lung Cell Mol Physiol 297:L109-14. 2009
Reactive oxygen species (ROS) present in cigarette smoke (CS) are thought to contribute to the development of COPD...
- Exposure of bronchial epithelial cells to whole cigarette smoke: assessment of cellular responses
British American Tobacco, Group R and D Centre, Southampton, UK
Altern Lab Anim 33:239-48. 2005
Cigarette smoke is composed of approximately 5% particulate phase and 95% vapour phase by weight. However, routine in vitro toxicological testing of smoke normally only measures the activity of the particulate phase...
- An analysis of effects of San Diego wildfire on ambient air quality
School of Engineering and Technology, National University, La Jolla, CA 92037, USA
J Air Waste Manag Assoc 56:56-67. 2006
..Fortunately, the absence of sunlight because of the cloud of thick smoke that covered most of the county during the fire appears to have prevented the photochemical conversion of the ..
- DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2
Laura L Koth
Division of Pulmonary and Critical Care Medicine, Lung Biology Center, University of California at San Francisco, San Francisco, CA 94143, USA
J Immunol 184:6522-8. 2010
..In vitro, cigarette smoke directly induced expression of myeloid DAP12-associated lectin-1 and TREM2 and activation of DAP12 signaling in ..
- Wood smoke exposure induces a pulmonary and systemic inflammatory response in firefighters
J R Swiston
The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
Eur Respir J 32:129-38. 2008
Epidemiological studies report an association between exposure to biomass smoke and cardiopulmonary morbidity. The mechanisms for this association are unclear...
- Estimating personal PM2.5 exposures using CO measurements in Guatemalan households cooking with wood fuel
Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
J Environ Monit 12:873-8. 2010
As a part of a longitudinal study in the highlands of Guatemala to elicit the chronic health effects of wood smoke from cooking, mean area and personal 48 h concentrations of 2.5 microm particulate matter (PM2...
- Enhancement of Candida albicans virulence after exposition to cigarette mainstream smoke
Fernanda Brasil Baboni
Laboratory of Stomatology, CCBS, Pontifical Catholic University of Parana, Rua Imaculada Conceição 1155, Curitiba, 80215 901, Brazil
Mycopathologia 168:227-35. 2009
..The effects of exposure to smoke on the virulence properties of oral yeasts remain obscure...
- Improved biomass stove intervention in rural Mexico: impact on the respiratory health of women
Environmental Health Department, National Institute of Public Health INSP, Cuernavaca, Morelos, Mexico
Am J Respir Crit Care Med 180:649-56. 2009
Exposure to biomass smoke has been related to adverse health effects. In Mexico, one household in four still cooks with biomass fuel, but there has been no evaluation of the health impact of reducing indoor air pollution.
- Comparison of two quantitative methods of discerning airspace enlargement in smoke-exposed mice
Richard E Jacob
Biological Monitoring and Modeling, Pacific Northwest National Laboratory, Richland, Washington, USA
PLoS ONE 4:e6670. 2009
..two methods for evaluating and quantifying pulmonary airspace enlargement in a mouse model of chronic cigarette smoke exposure...
- Cigarette smoke induces epidermal growth factor receptor-dependent redistribution of apical MUC1 and junctional beta-catenin in polarized human airway epithelial cells
Ying Ting Chen
University of California, San Francisco, Francis I Proctor Foundation, San Francisco, CA 94143, USA
Am J Pathol 177:1255-64. 2010
Cigarette smoke (CS) accounts for nearly 90% of lung cancer deaths worldwide; however, an incomplete understanding of how CS initiates preneoplastic changes in the normal airway hinders early diagnosis...
- Estimation and correlation of cigarette smoke exposure in Canadian smokers as determined by filter analysis and biomarkers of exposure
Imperial Tobacco Canada Limited, Montreal, Canada
Regul Toxicol Pharmacol 61:S3-12. 2011
A clinical study conducted in Canada compared two methods of estimating exposure to cigarette smoke in 192 volunteer subjects: 43 smokers of 4-6 mg, 49 of 8-12 mg and 50 of 14-15 mg ISO tar yield cigarettes and 50 non-smokers...
- Wood smoke exposure, poverty and impaired lung function in Malawian adults
D G Fullerton
Malawi Liverpool Wellcome Clinical Research Laboratories, Universities of Malawi and Liverpool UK, Blantyre, Malawi
Int J Tuberc Lung Dis 15:391-8. 2011
..Biomass smoke is associated with chronic obstructive pulmonary disease (COPD) in Asian and Central American countries, but there ..
- Reduced lung function due to biomass smoke exposure in young adults in rural Nepal
Om P Kurmi
Institute of Occupational and Environmental Medicine, University of Birmingham, Birmingham, UK
Eur Respir J 41:25-30. 2013
This study aimed to assess the effects of biomass smoke exposure on lung function in a Nepalese population, addressing some of the methodological issues seen in previous studies...
- Wood smoke exposure and gene promoter methylation are associated with increased risk for COPD in smokers
University of New Mexico School of Medicine, Albuquerque, New Mexico, USA
Am J Respir Crit Care Med 182:1098-104. 2010
Wood smoke-associated chronic obstructive pulmonary disease (COPD) is common in women in developing countries but has not been adequately described in developed countries.
- Oxidative damage in human gingival fibroblasts exposed to cigarette smoke
Department of Biology, Universita degli Studi di Milano, I 20133 Milan, Italy
Free Radic Biol Med 52:1584-96. 2012
Cigarette smoke, a complex mixture of over 7000 chemicals, contains many components capable of eliciting oxidative stress, which may induce smoking-related disorders, including oral cavity diseases...
- Immunotoxicology of arc welding fume: worker and experimental animal studies
Patti C Zeidler-Erdely
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
J Immunotoxicol 9:411-25. 2012
..The objective of this report was to review both human and animal studies that have examined the effect of welding fume pulmonary exposure on local and systemic immune responses...
- Genomic impact of cigarette smoke, with application to three smoking-related diseases
Philip Morris International R and D, Philip Morris Products S A, Neuchatel, Switzerland
Crit Rev Toxicol 42:877-89. 2012
There is considerable evidence that inhaled toxicants such as cigarette smoke can cause both irreversible changes to the genetic material (DNA mutations) and putatively reversible changes to the epigenetic landscape (changes in the DNA ..
- Tobacco smoke induces the generation of procoagulant microvesicles from human monocytes/macrophages
Section of Endocrinology, Diabetes and Metabolism, Temple University School of Medicine, Philadelphia, PA 19140, USA
Arterioscler Thromb Vasc Biol 30:1818-24. 2010
To investigate whether exposure of human monocytes/macrophages to tobacco smoke induces their release of membrane microvesicles (MVs) that carry tissue factor (TF) released from cells, whether smoke-induced MVs are procoagulant, and what ..
- Cigarette smoke induced airway inflammation is independent of NF-κB signalling
Joseph M D Rastrick
Respiratory Pharmacology, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
PLoS ONE 8:e54128. 2013
COPD is an inflammatory lung disease largely associated with exposure to cigarette smoke (CS)...
- Tobacco smoke cooperates with interleukin-1beta to alter beta-catenin trafficking in vascular endothelium resulting in increased permeability and induction of cyclooxygenase-2 expression in vitro and in vivo
Silvia S Barbieri
Division of Hematology Medical Oncology, Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10021, USA
FASEB J 21:1831-43. 2007
..We explored activation by exposure to tobacco smoke of two genes, beta-catenin and COX-2, that play key roles in inflammation and vascular remodeling events...
- Cigarette smoke and α,β-unsaturated aldehydes elicit VEGF release through the p38 MAPK pathway in human airway smooth muscle cells and lung fibroblasts
Department of Pharmacology, Chiesi Farmaceutici s p a, Parma, Italy
Br J Pharmacol 163:649-61. 2011
..The aim of this study was to investigate whether acute exposure to cigarette smoke extract altered VEGF production in lung parenchymal cells.
- Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress
Airway Disease Section, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
Biochem Biophys Res Commun 406:292-8. 2011
..Nrf2-regulated heme-oxygenase-1 (HO-1) expression in these cells, and this was confirmed in acute cigarette-smoke exposed mice in vivo...
- The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts
C A Martey
Chemistry Department, Shippensburg University, Pennsylvania, USA
Am J Physiol Lung Cell Mol Physiol 289:L391-9. 2005
..We recently demonstrated that human lung fibroblasts are activated by cigarette smoke to express COX-2 and prostaglandin E(2) (PGE(2))...
- Oxidative damage to DNA and repair induced by Norwegian wood smoke particles in human A549 and THP-1 cell lines
Pernille Høgh Danielsen
Institute of Public Health, Department of Environmental Health, University of Copenhagen, Øster Farimagsgade 5A, DK 1014 Copenhagen K, Denmark
Mutat Res 674:116-22. 2009
..The aim of this study was to compare the genotoxicity of wood smoke particulate matter (WSPM), authentic traffic-generated particles, mineral PM and standard reference material (..
- Bone marrow cells repair cigarette smoke-induced emphysema in rats
Jin Won Huh
Dept of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan Univ School of Medicine, Suwon 440 746, South Korea
Am J Physiol Lung Cell Mol Physiol 301:L255-66. 2011
..marrow cells (BMCs), mesenchymal stem cells (MSCs), and conditioned media of MSCs (MSC-CM) to repair cigarette smoke-induced emphysema...
- Association of secondhand smoke exposures with DNA methylation in bladder carcinomas
Charlotte S Wilhelm-Benartzi
Department of Community Health Center for Environmental Health and Technology, Brown University, Providence, RI, USA
Cancer Causes Control 22:1205-13. 2011
The association between secondhand smoke (SHS) exposure and bladder cancer is inconclusive...
- Exposure to wood smoke particles produces inflammation in healthy volunteers
Andrew J Ghio
The National Health and Environmental Effects Research Laboratory, US EPA, Research Triangle Park, North Carolina, USA
Occup Environ Med 69:170-5. 2012
Human exposure to wood smoke particles (WSP) impacts on human health through changes in indoor air quality, exposures from wild fires, burning of biomass and air pollution...
- Sidestream tobacco smoke is a male germ cell mutagen
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 108:12811-4. 2011
..However, little is known regarding the effects of second-hand smoke on the male germ line...
- Mitochondrial localization and function of heme oxygenase-1 in cigarette smoke-induced cell death
Dirk Jan Slebos
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, MUH 628NW, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
Am J Respir Cell Mol Biol 36:409-17. 2007
Cigarette smoke-induced apoptosis and necrosis contribute to the pathogenesis of chronic obstructive pulmonary disease...
- Effects of sidestream cigarette smoke exposure on baroreflex components in spontaneously hypertensive rats
Vitor E Valenti
Departamento de Medicina, Disciplina de Cardiologia, Universidade Federal de Sao Paulo UNIFESP, Sao Paulo, Brazil
Int J Environ Health Res 20:431-7. 2010
We evaluated short-term effects of sidestream cigarette smoke (SSCS) exposure on baroreflex function in spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) normotensive rats...
- Cigarette smoke induces promoter methylation of single-stranded DNA-binding protein 2 in human esophageal squamous cell carcinoma
Department of Dermatology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Int J Cancer 128:2261-73. 2011
..squamous cell carcinoma (ESCC) is the sixth most frequent cause of cancer death in the world, and cigarette smoke is a key factor in esophageal carcinogenesis...
- alpha-1-Antitrypsin ameliorates cigarette smoke-induced emphysema in the mouse
Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5
Am J Respir Crit Care Med 168:199-207. 2003
Serine elastase inhibitors have been proposed as a treatment for cigarette smoke-induced emphysema, but little is known about whether such agents actually are effective...
- Inhibition of IFN-gamma-dependent antiviral airway epithelial defense by cigarette smoke
Modestos A Modestou
Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, Iowa 52242 1081, USA
Respir Res 11:64. 2010
Although individuals exposed to cigarette smoke are more susceptible to respiratory infection, the effects of cigarette smoke on lung defense are incompletely understood...
- Antioxidant airway responses following experimental exposure to wood smoke in man
Department of Public Health and Clinical Medicine, Division of Medicine, Umea University, Umea, Sweden
Part Fibre Toxicol 7:21. 2010
..The aim of this study was therefore to characterize airway responses in humans exposed to wood smoke PM under controlled conditions...
- Menthol sensory qualities and smoking topography: a review of tobacco industry documents
Valerie B Yerger
Department of Social and Behavioral Sciences, University of California, San Francisco, Box 0612, San Francisco, CA 94143 0612, USA
Tob Control 20:ii37-43. 2011
..To determine what the tobacco industry knew about the potential effects of menthol on smoking topography-how a person smokes a cigarette...
- The effect of tobacco ingredients on smoke chemistry. Part II: casing ingredients
Richard R Baker
British American Tobacco, Research and Development Centre, Regent s Park Road, Southampton SO15 8TL, UK
Food Chem Toxicol 42:S39-52. 2004
..a study in which the effects of adding a range of ingredients to tobacco on the chemistry of cigarette mainstream smoke are assessed...
- An animal model of cigarette smoke-induced in utero growth retardation
Emily R Esposito
University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, ULSD, 501 South Preston Street, Suite 301, Louisville, KY 40292, USA
Toxicology 246:193-202. 2008
..Over one million babies are exposed prenatally to cigarette smoke accounting for over 20% of the LBW incidence in the US...
- The transcriptome of Nrf2-/- mice provides evidence for impaired cell cycle progression in the development of cigarette smoke-induced emphysematous changes
Philip Morris Research Laboratories GmbH, Philip Morris International Research and Development, Koln, Germany
Toxicol Sci 115:238-52. 2010
Cigarette smoke (CS) imposes a strong oxidative burden on exposed tissues resulting in a severely disturbed oxidant/antioxidant balance, which in the context of chronic exposure is assumed to be a key contributor to CS-related diseases...
- The effect of tobacco ingredients on smoke chemistry. Part I: Flavourings and additives
Richard R Baker
British American Tobacco, Research and Development Centre, Regent s Park Road, Southampton SO15 8TL, UK
Food Chem Toxicol 42:S3-37. 2004
..effects of 450 tobacco ingredients added to tobacco on the forty-four "Hoffmann analytes" in mainstream cigarette smoke have been determined...