insect vectors

Summary

Summary: Insects that transmit infective organisms from one host to another or from an inanimate reservoir to an animate host.

Top Publications

  1. ncbi Pyrethroid resistance in African anopheline mosquitoes: what are the implications for malaria control?
    Hilary Ranson
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK, L3 5QA
    Trends Parasitol 27:91-8. 2011
  2. ncbi Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission
    A A Hoffmann
    Bio21 Institute, Department of Genetics, The University of Melbourne, Victoria 3010, Australia
    Nature 476:454-7. 2011
  3. pmc Genome sequence of Aedes aegypti, a major arbovirus vector
    Vishvanath Nene
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 316:1718-23. 2007
  4. pmc Increased proportions of outdoor feeding among residual malaria vector populations following increased use of insecticide-treated nets in rural Tanzania
    Tanya L Russell
    Ifakara Health Institute, Biomedical and Environmental Thematic Group, Ifakara, Tanzania
    Malar J 10:80. 2011
  5. pmc A research agenda to underpin malaria eradication
    Pedro L Alonso
    Barcelona Centre for International Health Research Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
    PLoS Med 8:e1000406. 2011
  6. pmc A single mutation in chikungunya virus affects vector specificity and epidemic potential
    Konstantin A Tsetsarkin
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS Pathog 3:e201. 2007
  7. pmc Impact of daily temperature fluctuations on dengue virus transmission by Aedes aegypti
    Louis Lambrechts
    Department of Virology, Institut Pasteur, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 108:7460-5. 2011
  8. ncbi Critical review of the vector status of Aedes albopictus
    N G Gratz
    Med Vet Entomol 18:215-27. 2004
  9. pmc Species shifts in the Anopheles gambiae complex: do LLINs successfully control Anopheles arabiensis?
    Jovin Kitau
    Kilimanjaro Christian Medical College, Tumaini University, Moshi, Tanzania
    PLoS ONE 7:e31481. 2012
  10. ncbi Global spread and persistence of dengue
    Jennifer L Kyle
    Division of Infectious Diseases, School of Public Health, and Graduate Group in Microbiology, University of California, Berkeley, California 94720 7354, USA
    Annu Rev Microbiol 62:71-92. 2008

Detail Information

Publications361 found, 100 shown here

  1. ncbi Pyrethroid resistance in African anopheline mosquitoes: what are the implications for malaria control?
    Hilary Ranson
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK, L3 5QA
    Trends Parasitol 27:91-8. 2011
    ..As we move into the malaria eradication era, it is vital that the implications of insecticide resistance are understood and strategies to mitigate these effects are implemented...
  2. ncbi Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission
    A A Hoffmann
    Bio21 Institute, Department of Genetics, The University of Melbourne, Victoria 3010, Australia
    Nature 476:454-7. 2011
    ..These findings demonstrate that Wolbachia-based strategies can be deployed as a practical approach to dengue suppression with potential for area-wide implementation...
  3. pmc Genome sequence of Aedes aegypti, a major arbovirus vector
    Vishvanath Nene
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 316:1718-23. 2007
    ..An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species...
  4. pmc Increased proportions of outdoor feeding among residual malaria vector populations following increased use of insecticide-treated nets in rural Tanzania
    Tanya L Russell
    Ifakara Health Institute, Biomedical and Environmental Thematic Group, Ifakara, Tanzania
    Malar J 10:80. 2011
    ..In the surveyed area of rural southern Tanzania, bed net use steadily increased over the last decade, reducing malaria transmission intensity by 94%...
  5. pmc A research agenda to underpin malaria eradication
    Pedro L Alonso
    Barcelona Centre for International Health Research Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
    PLoS Med 8:e1000406. 2011
    ....
  6. pmc A single mutation in chikungunya virus affects vector specificity and epidemic potential
    Konstantin A Tsetsarkin
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS Pathog 3:e201. 2007
    ..Due to the widespread distribution of Ae. albopictus, this mutation increases the potential for CHIKV to permanently extend its range into Europe and the Americas...
  7. pmc Impact of daily temperature fluctuations on dengue virus transmission by Aedes aegypti
    Louis Lambrechts
    Department of Virology, Institut Pasteur, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 108:7460-5. 2011
    ..Our findings reveal the importance of considering short-term temperature variations when studying DENV transmission dynamics...
  8. ncbi Critical review of the vector status of Aedes albopictus
    N G Gratz
    Med Vet Entomol 18:215-27. 2004
    ..albopictus in countries endemic for dengue and other arboviruses (e.g. Chikungunya, EEE, Ross River, WNV, LaCrosse and other California group viruses), for which it would be competent and ecologically suited to serve as a bridge vector...
  9. pmc Species shifts in the Anopheles gambiae complex: do LLINs successfully control Anopheles arabiensis?
    Jovin Kitau
    Kilimanjaro Christian Medical College, Tumaini University, Moshi, Tanzania
    PLoS ONE 7:e31481. 2012
    ..Shifts in malaria vector species ratio have coincided with the scale-up suggesting that some species are being controlled by ITNs/LLINs better than others...
  10. ncbi Global spread and persistence of dengue
    Jennifer L Kyle
    Division of Infectious Diseases, School of Public Health, and Graduate Group in Microbiology, University of California, Berkeley, California 94720 7354, USA
    Annu Rev Microbiol 62:71-92. 2008
    ..What is known, as well as gaps in knowledge, is emphasized in light of future prospects for control and prevention of this pandemic disease...
  11. pmc Sequencing of Culex quinquefasciatus establishes a platform for mosquito comparative genomics
    Peter Arensburger
    Center for Disease Vector Research, University of California Riverside, Riverside, CA 92521, USA
    Science 330:86-8. 2010
    ....
  12. pmc Globalization, land use, and the invasion of West Nile virus
    A Marm Kilpatrick
    Department of Ecology and Evolutionary Biology, University of California, Santa Cruz, CA 95064, USA
    Science 334:323-7. 2011
    ..This research provides a framework for predicting and preventing the emergence of foreign vector-borne pathogens...
  13. pmc Anopheles gambiae: historical population decline associated with regional distribution of insecticide-treated bed nets in western Nyanza Province, Kenya
    M Nabie Bayoh
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA
    Malar J 9:62. 2010
    ..l.) species complex, namely A. gambiae sensu stricto (s.s.) and Anopheles arabiensis. Historically, the former species was proportionately dominant in indoor resting collections of females...
  14. ncbi A climate-based distribution model of malaria transmission in sub-Saharan Africa
    M H Craig
    National Malaria Research Programme, South African Medical Research Council, PO Box 17120, Congella, Durban 4013, South Africa
    Parasitol Today 15:105-11. 1999
    ..Together with population, morbidity and mortality data, the model provides a fundamental tool for strategic control of malaria...
  15. pmc Spread of the tiger: global risk of invasion by the mosquito Aedes albopictus
    Mark Q Benedict
    Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Vector Borne Zoonotic Dis 7:76-85. 2007
    ..Methods used here have potential for predicting risks of future invasions of vectors or pathogens...
  16. pmc Natural microbe-mediated refractoriness to Plasmodium infection in Anopheles gambiae
    Chris M Cirimotich
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205 2179, USA
    Science 332:855-8. 2011
    ..We show that this anti-Plasmodium effect is largely caused by bacterial generation of reactive oxygen species...
  17. pmc Implication of the mosquito midgut microbiota in the defense against malaria parasites
    Yuemei Dong
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Pathog 5:e1000423. 2009
    ..We show that the microbiota can modulate the anti-Plasmodium effects of some immune genes. In sum, the microbiota plays an essential role in modulating the mosquito's capacity to sustain Plasmodium infection...
  18. pmc West Nile fever--a reemerging mosquito-borne viral disease in Europe
    Z Hubalek
    Institute of Vertebrate Biology, Academy of Sciences, Brno, Czech Republic
    Emerg Infect Dis 5:643-50. 1999
    ....
  19. ncbi Odor-mediated behavior of Afrotropical malaria mosquitoes
    W Takken
    Laboratory of Entomology, Wageningen Agricultural University, The Netherlands
    Annu Rev Entomol 44:131-57. 1999
    ..It is foreseen that increased knowledge of odor-mediated behaviors will be applied in the development of novel sampling techniques and possibly alternative methods of intervention to control malaria...
  20. ncbi A global perspective on the epidemiology of West Nile virus
    Laura D Kramer
    The Arbovirus Laboratories, Wadsworth Center, New York State Department of Health, Slingerlands, NY 12159, USA
    Annu Rev Entomol 53:61-81. 2008
    ..Vector control strategies, vaccines, and antivirals, which now must be considered on a global scale, are also discussed...
  21. pmc Influence of climate on malaria transmission depends on daily temperature variation
    Krijn P Paaijmans
    Department of Entomology, Center for Infectious Disease Dynamics, Penn State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 107:15135-9. 2010
    ....
  22. pmc Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes
    Zakaria Kambris
    Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Science 326:134-6. 2009
    ..The cost of constitutive immune up-regulation may contribute to the life-shortening phenotype...
  23. ncbi Mosquito behavior and vector control
    Helen Pates
    London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom
    Annu Rev Entomol 50:53-70. 2005
    ..Prospects for genetic control by sterile males or genes rendering mosquitoes harmless to humans will depend on competitive mating behavior. These methods are hampered by the immigration of monogamous, already-mated females...
  24. pmc Warmer temperatures reduce the vectorial capacity of malaria mosquitoes
    Krijn P Paaijmans
    Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA 16802, USA
    Biol Lett 8:465-8. 2012
    ..These results highlight the need to understand the interactive effects of environmental temperature on multiple host-disease life-history traits and challenge the assumptions of many current disease models that ignore this complexity...
  25. ncbi Stable introduction of a life-shortening Wolbachia infection into the mosquito Aedes aegypti
    Conor J McMeniman
    School of Integrative Biology, University of Queensland, Brisbane 4072, Australia
    Science 323:141-4. 2009
    ..Our data suggest that targeting mosquito age with inherited Wolbachia infections may be a viable strategy to reduce the transmission of pathogens such as dengue viruses...
  26. ncbi Indoor residual spraying for preventing malaria
    Bianca Pluess
    Public Health and Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland, 4002
    Cochrane Database Syst Rev 4:CD006657. 2010
    ..Some limited data suggest that ITN give better protection than IRS in unstable areas, but more trials are needed to compare the effects of ITNs with IRS, as well as to quantify their combined effects...
  27. pmc Two duplicated P450 genes are associated with pyrethroid resistance in Anopheles funestus, a major malaria vector
    Charles S Wondji
    Liverpool School of Tropical Medicine, Liverpool, L3 5QA, United Kingdom
    Genome Res 19:452-9. 2009
    ..This will be a major advance for insecticide resistance management in malaria vectors, which requires the early detection of resistance alleles...
  28. pmc Modeling the effects of weather and climate change on malaria transmission
    Paul Edward Parham
    Department of Infectious Disease Epidemiology, Grantham Institute for Climate Change, Imperial College London, London, United Kingdom
    Environ Health Perspect 118:620-6. 2010
    ....
  29. pmc De novo transcriptome sequencing in Anopheles funestus using Illumina RNA-seq technology
    Jacob E Crawford
    Department of Entomology, Cornell University, Ithaca, New York, United States of America
    PLoS ONE 5:e14202. 2010
    ..funestus from a newly founded colony in Burkina Faso, West Africa, using the Illumina GAIIx next generation sequencing platform...
  30. pmc A synthetic homing endonuclease-based gene drive system in the human malaria mosquito
    Nikolai Windbichler
    Imperial College London, Department of Life Sciences, South Kensington Campus, London, SW7 2AZ, UK
    Nature 473:212-5. 2011
    ..Our results also show in principle how sequence-specific genetic drive elements like HEGs could be used to take the step from the genetic engineering of individuals to the genetic engineering of populations...
  31. ncbi Culicoides biting midges: their role as arbovirus vectors
    P S Mellor
    Institute for Animal Health, Woking, Surrey, UK
    Annu Rev Entomol 45:307-40. 2000
    ....
  32. ncbi Chikungunya, an epidemic arbovirosis
    Gilles Pialoux
    Hopital Tenon, Service des Maladies Infectieuses et Tropicales, Paris, France
    Lancet Infect Dis 7:319-27. 2007
    ..Plausible explanations include increased tourism, chikungunya virus introduction into a naive population, and viral mutation...
  33. pmc Suitability of European climate for the Asian tiger mosquito Aedes albopictus: recent trends and future scenarios
    Cyril Caminade
    School of Environmental Sciences, University of Liverpool, Liverpool, UK
    J R Soc Interface 9:2708-17. 2012
    ..These distribution shifts are related to wetter and warmer conditions favouring the overwintering of A. albopictus in the north, and drier and warmer summers that might limit its southward expansion...
  34. pmc "Bird biting" mosquitoes and human disease: a review of the role of Culex pipiens complex mosquitoes in epidemiology
    Ary Farajollahi
    Rutgers University, Center for Vector Biology, New Brunswick, NJ, USA
    Infect Genet Evol 11:1577-85. 2011
    ..We highlight several unanswered questions that will increase our ability to control diseases transmitted by these mosquitoes...
  35. pmc Integrated malaria vector control with microbial larvicides and insecticide-treated nets in western Kenya: a controlled trial
    Ulrike Fillinger
    Disease Control and Vector Biology Unit, London School of Hygiene and Tropical Medicine, London, England
    Bull World Health Organ 87:655-65. 2009
    ....
  36. pmc Hemocyte differentiation mediates innate immune memory in Anopheles gambiae mosquitoes
    Janneth Rodrigues
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892, USA
    Science 329:1353-5. 2010
    ..In mosquitoes, differentiation of hemocytes was necessary and sufficient to confer innate immune memory...
  37. ncbi Spatial and temporal heterogeneity of Anopheles mosquitoes and Plasmodium falciparum transmission along the Kenyan coast
    Charles M Mbogo
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Am J Trop Med Hyg 68:734-42. 2003
    ..The field-based estimate of entomologic parameters on a district level does not provide a sensitive indicator of transmission intensity in this study...
  38. ncbi Invasions by insect vectors of human disease
    L Philip Lounibos
    Florida Medical Entomology Laboratory, University of Florida, Vero Beach, Florida 32962, USA
    Annu Rev Entomol 47:233-66. 2002
    ..Propagule pressure, previous success, and adaptations to human habits appear to favor successful invasions by vectors...
  39. pmc Odorant reception in the malaria mosquito Anopheles gambiae
    Allison F Carey
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Nature 464:66-71. 2010
    ..Our analysis of the Anopheles gambiae repertoire identifies receptors that may be useful targets for controlling the transmission of malaria...
  40. pmc A comprehensive gene expression atlas of sex- and tissue-specificity in the malaria vector, Anopheles gambiae
    Dean A Baker
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB1 3QA, UK
    BMC Genomics 12:296. 2011
    ..Identifying genes expressed in particular tissues or involved in specific biological processes is an essential part of this process...
  41. pmc Mosquito immune defenses against Plasmodium infection
    Chris M Cirimotich
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    Dev Comp Immunol 34:387-95. 2010
    ....
  42. pmc The endosymbiotic bacterium Wolbachia induces resistance to dengue virus in Aedes aegypti
    Guowu Bian
    Department of Entomology and Genetics Program, Michigan State University, East Lansing, Michigan, United States of America
    PLoS Pathog 6:e1000833. 2010
    ..These results underscore the potential usefulness of Wolbachia-based control strategies for population replacement...
  43. ncbi The effect of deforestation on the human-biting rate of Anopheles darlingi, the primary vector of Falciparum malaria in the Peruvian Amazon
    Amy Yomiko Vittor
    School of Medicine, Stanford University, Stanford, California, USA
    Am J Trop Med Hyg 74:3-11. 2006
    ..Our results indicate that A. darlingi displays significantly increased human-biting activity in areas that have undergone deforestation and development associated with road development...
  44. pmc Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model
    Regis Gomes
    Centro de Pesquisas Goncalo Moniz, Fundacao Oswaldo Cruz, CEP 40296 710 Salvador, Brazil
    Proc Natl Acad Sci U S A 105:7845-50. 2008
    ....
  45. pmc Understanding the link between malaria risk and climate
    Krijn P Paaijmans
    Center for Infectious Disease Dynamics, Department of Entomology, Chemical Ecology Laboratory, Pennsylvania State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 106:13844-9. 2009
    ..Such effects of short-term temperature fluctuations have not previously been considered but are central to understanding current malaria transmission and the consequences of climate change...
  46. ncbi The impact of Chagas disease control in Latin America: a review
    J C P Dias
    Centro de Pesquisas Rene Rachou, FIOCRUZ, Belo Horizonte, MG, 30190 002, Brasil
    Mem Inst Oswaldo Cruz 97:603-12. 2002
    ..the main control strategy relies on prevention of transmission, principally by eliminating the domestic insect vectors and control of transmission by blood transfusion...
  47. ncbi A cocktail polymerase chain reaction assay to identify members of the Anopheles funestus (Diptera: Culicidae) group
    L L Koekemoer
    Department of Clinical Microbiology and Infectious Diseases, School of Pathology of the National Health Laboratory Services and the University of the Witwatersrand, Johannesburg, South Africa
    Am J Trop Med Hyg 66:804-11. 2002
    ....
  48. ncbi Comparative genomics: Insecticide resistance in mosquito vectors
    Mylene Weill
    Institut des Sciences de l Evolution, UMR 5554, CC 065, Universite Montpellier II, 34095 Montpellier, France
    Nature 423:136-7. 2003
  49. pmc Epidemiology and transmission dynamics of West Nile virus disease
    Edward B Hayes
    Centers for Disease Control and Prevention, Fort Collins, Colorado 80526, USA
    Emerg Infect Dis 11:1167-73. 2005
    ..This review highlights new information regarding the epidemiology and dynamics of WNV transmission, providing a new platform for further research into preventing and controlling WNV disease...
  50. pmc Development of a new version of the Liverpool Malaria Model. I. Refining the parameter settings and mathematical formulation of basic processes based on a literature review
    Volker Ermert
    Institute of Geophysics and Meteorology, University of Cologne, Cologne, Germany
    Malar J 10:35. 2011
    ..In this study, the parameter settings of the LMM are refined and a new mathematical formulation of key processes related to the growth and size of the vector population are developed...
  51. ncbi The genome sequence of the malaria mosquito Anopheles gambiae
    Robert A Holt
    Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
    Science 298:129-49. 2002
    ..An expressed sequence tag analysis of genes regulated by blood feeding provided insights into the physiological adaptations of a hematophagous insect...
  52. pmc Larval source management for malaria control in Africa: myths and reality
    Ulrike Fillinger
    Department of Disease Control, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Malar J 10:353. 2011
    ....
  53. ncbi A global index representing the stability of malaria transmission
    Anthony Kiszewski
    Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Trop Med Hyg 70:486-98. 2004
    ....
  54. ncbi Influence of temperature on immature development, survival, longevity, fecundity, and gonotrophic cycles of Aedes albopictus, vector of chikungunya and dengue in the Indian Ocean
    H Delatte
    Research Unit 016, Institut de recherche pour le developpement IRD, 7 chemin de l IRAT, 97410 Saint Pierre, La Reunion, France
    J Med Entomol 46:33-41. 2009
    ..5 d). Those results are according to the field repartition of this species in La Réunion, allowing Ae. albopictus survival at a large range of temperatures...
  55. pmc A cryptic subgroup of Anopheles gambiae is highly susceptible to human malaria parasites
    Michelle M Riehle
    Institut Pasteur, Unit of Insect Vector Genetics and Genomics, Department of Parasitology and Mycology, 28 rue du Docteur Roux, Paris 75015, France
    Science 331:596-8. 2011
    ..These findings might have implications for the epidemiology of malaria transmission and control...
  56. pmc Insecticide resistance and the future of malaria control in Zambia
    Emmanuel Chanda
    Ministry of Health, National Malaria Control Centre, Lusaka, Zambia
    PLoS ONE 6:e24336. 2011
    ..This manuscript reports on the monitoring and evaluation of these activities and the potential impact of emerging insecticide resistance on disease transmission...
  57. pmc Sterile-insect methods for control of mosquito-borne diseases: an analysis
    Luke Alphey
    Oxitec Limited, Oxford, United Kingdom
    Vector Borne Zoonotic Dis 10:295-311. 2010
    ..This article attempts to address these concerns and indicate where sterile-insect methods are likely to be useful for vector control...
  58. ncbi A newly emergent genotype of West Nile virus is transmitted earlier and more efficiently by Culex mosquitoes
    Robin M Moudy
    Arbovirus Laboratories, Wadsworth Center, New York State Department of Health, 5668 State Farm Road, Slingerlands, NY 12159, USA
    Am J Trop Med Hyg 77:365-70. 2007
    ..These results suggest a model for the displacement of the NY99 genotype, where earlier transmission of WN02 viruses leads to higher WN02 infection rates in avian reservoir hosts...
  59. ncbi Host selection by Culex pipiens mosquitoes and West Nile virus amplification
    Gabriel L Hamer
    Department of Fisheries and Wildlife, Michigan State University, East Lansing, Michigan 48910, USA
    Am J Trop Med Hyg 80:268-78. 2009
    ..pipiens became infected from feeding on just a few species of birds, including American robins (35%), blue jays (17%, Cyanocitta cristata), and house finches (15%, Carpodacus mexicanus)...
  60. pmc Female-specific flightless phenotype for mosquito control
    Guoliang Fu
    Oxitec Limited, 71 Milton Park, Oxford OX14 4RX, United Kingdom
    Proc Natl Acad Sci U S A 107:4550-4. 2010
    ..Furthermore, these strains are expected to facilitate area-wide control or elimination of dengue if adopted as part of an integrated pest management strategy...
  61. pmc Distribution of knock-down resistance mutations in Anopheles gambiae molecular forms in west and west-central Africa
    Federica Santolamazza
    Istituto Pasteur Fondazione Cenci Bolognetti, Universita La Sapienza, Rome, Italy
    Malar J 7:74. 2008
    ..In M-form populations surveyed to date, only the L1014F mutation has been found, although less widespread and at lower frequencies than in sympatric S-form populations...
  62. ncbi Control of Japanese encephalitis--within our grasp?
    Tom Solomon
    United Kingdom Medical Research Council, United Kingdom
    N Engl J Med 355:869-71. 2006
  63. ncbi Insect vector interactions with persistently transmitted viruses
    Saskia A Hogenhout
    Department of Disease and Stress Biology, John Innes Centre, Norwich, NR4 7UH, United Kingdom
    Annu Rev Phytopathol 46:327-59. 2008
    ..The movement and/or replication of the viruses in the insect vectors require specific interactions between virus and vector components...
  64. pmc Open field release of genetically engineered sterile male Aedes aegypti in Malaysia
    Renaud Lacroix
    Oxitec Sendirian Berhad, Kuala Lumpur, Wilayah persekutuan, Malaysia
    PLoS ONE 7:e42771. 2012
    ..New methods are therefore urgently needed, for example genetics-based sterile-male-release methods. However, this requires that lab-reared, modified mosquitoes be able to survive and disperse adequately in the field...
  65. pmc An evolutionary conserved function of the JAK-STAT pathway in anti-dengue defense
    Jayme A Souza-Neto
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, The Johns Hopkins University, 615 North Wolfe Street E4209, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 106:17841-6. 2009
    ..Our data suggest that the JAK-STAT pathway is part of the A. aegypti mosquito's anti-dengue defense and may act independently of the Toll pathway and the RNAi-mediated antiviral defenses...
  66. pmc Transcriptome of the adult female malaria mosquito vector Anopheles albimanus
    Jesus Martinez-Barnetche
    Centro De Investigacion sobre Enfermedades Infecciosas, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico
    BMC Genomics 13:207. 2012
    ..To better understand the biological basis of malaria transmission and to develop novel and effective means of vector control, there is a need to explore the mosquito biology beyond the An. gambiae complex...
  67. ncbi The Innovative Vector Control Consortium: improved control of mosquito-borne diseases
    Janet Hemingway
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK, L3 5QA
    Trends Parasitol 22:308-12. 2006
    ....
  68. pmc Caspar controls resistance to Plasmodium falciparum in diverse anopheline species
    Lindsey S Garver
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
    PLoS Pathog 5:e1000335. 2009
    ..These findings have implications for malaria control since broad-spectrum immune activation in diverse anopheline species offers a viable and strategic approach to develop novel malaria control methods worldwide...
  69. ncbi Aedes albopictus, an arbovirus vector: from the darkness to the light
    C Paupy
    Institut de Recherche pour le Developpement, UR016, BP 1857 Yaoundé, Cameroon
    Microbes Infect 11:1177-85. 2009
    ..Finally, we report conventional and innovative ways to control A. albopictus...
  70. ncbi Impact of permethrin-treated bed nets on entomologic indices in an area of intense year-round malaria transmission
    John E Gimnig
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:16-22. 2003
    ..These results indicate that ITNs are optimally effective if used every night and if permethrin is reapplied at least biannually...
  71. pmc Integrated vector management for malaria control
    John C Beier
    Department of Epidemiology and Public Health, Miller School of Medicine, and the Abess Center for Ecosystem Science and Policy, University of Miami, South Campus, Miami, FL 33177, USA
    Malar J 7:S4. 2008
    ..This review provides an overview of how IVM programmes are being implemented, and provides recommendations for further development of IVM to meet the goals of national malaria control programmes in Africa...
  72. pmc Spatial evaluation and modeling of Dengue seroprevalence and vector density in Rio de Janeiro, Brazil
    Nildimar Alves Honorio
    Laboratório de Transmissores de Hematozoários, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brasil
    PLoS Negl Trop Dis 3:e545. 2009
    ..We analyzed individual and spatial factors associated with seroprevalence using Generalized Additive Model (GAM)...
  73. pmc Eco-bio-social determinants of dengue vector breeding: a multicountry study in urban and periurban Asia
    Natarajan Arunachalam
    Centre for Research in Medical Entomology, Indian Council of Medical Research, Madurai, TN, India
    Bull World Health Organ 88:173-84. 2010
    ....
  74. pmc Local adaptation and vector-mediated population structure in Plasmodium vivax malaria
    Deirdre A Joy
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Mol Biol Evol 25:1245-52. 2008
    ....
  75. pmc The multiplicity of malaria transmission: a review of entomological inoculation rate measurements and methods across sub-Saharan Africa
    Louise A Kelly-Hope
    Vector Group, Liverpool School of Tropical Medicine, Liverpool, UK
    Malar J 8:19. 2009
    ....
  76. ncbi Climate change and highland malaria: fresh air for a hot debate
    Luis Fernando Chaves
    Department of Environmental Studies, Emory University, Atlanta, GA 30322, USA
    Q Rev Biol 85:27-55. 2010
    ....
  77. pmc Transmission of Leishmania metacyclic promastigotes by phlebotomine sand flies
    Paul A Bates
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Int J Parasitol 37:1097-106. 2007
    ..Differences in the transmission mechanisms employed by parasites in the three subgenera, Leishmania, Viannia and Sauroleishmania are also addressed...
  78. pmc Dengue virus type 2: replication and tropisms in orally infected Aedes aegypti mosquitoes
    Ma Isabel Salazar
    Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523 1692, USA
    BMC Microbiol 7:9. 2007
    ..Here we document the virogenesis of DENV-2 in newly-colonized Aedes aegypti mosquitoes from Chetumal, Mexico in order to understand better the effect of vector-virus interactions on dengue transmission...
  79. pmc Yersinia pestis--etiologic agent of plague
    R D Perry
    Department of Microbiology and Immunology, University of Kentucky, Lexington 40536, USA
    Clin Microbiol Rev 10:35-66. 1997
    ..These areas of research have provide new insights into the host-parasite relationship. This review will update our present understanding of the history, etiology, epidemiology, clinical aspects, and public health issues of plague...
  80. pmc Exploiting the potential of vector control for disease prevention
    H Townson
    Liverpool School of Tropical Medicine, Liverpool, England
    Bull World Health Organ 83:942-7. 2005
    ....
  81. pmc Molecular basis of odor coding in the malaria vector mosquito Anopheles gambiae
    Guirong Wang
    Department of Biological Sciences, Center for Molecular Neuroscience, Institutes of Chemical Biology and Global Health, Vanderbilt University, Nashville, TN 37235, USA
    Proc Natl Acad Sci U S A 107:4418-23. 2010
    ..gambiae that ultimately may aid in fostering the design and development of olfactory-based strategies for reducing the transmission of malaria and other mosquito-borne diseases...
  82. ncbi Anopheles gambiae s.s. breeding in polluted water bodies in urban Lagos, southwestern Nigeria
    T S Awolola
    Public Health Division, Nigerian Institute of Medical Research, Yaba, Lagos, Nigeria
    J Vector Borne Dis 44:241-4. 2007
    ..Urban malaria is on the rise in Nigeria due to rapid industrialisation and developmental activities. A study was undertaken in Lagos, Nigeria to study the Anopheles breeding in polluted water bodies...
  83. pmc Vector-virus mutualism accelerates population increase of an invasive whitefly
    Min Jiu
    Institute of Insect Sciences, Zhejiang University, Hangzhou, China
    PLoS ONE 2:e182. 2007
    ....
  84. pmc Defining challenges and proposing solutions for control of the virus vector Aedes aegypti
    Amy C Morrison
    Department of Entomology, University of California, Davis, Davis, California, United States of America
    PLoS Med 5:e68. 2008
  85. ncbi Evaluation of the antibody response to Anopheles salivary antigens as a potential marker of risk of malaria
    Franck Remoue
    Institut de recherche pour le developpement IRD, UR24 Epidémiologie et Prévention Unit, Centre IRD de Hann, BP 1386, Dakar, Senegal
    Trans R Soc Trop Med Hyg 100:363-70. 2006
    ..These results suggest that evaluation of antisalivary Ab responses could be a useful approach for identifying a marker for the risk of malaria transmission...
  86. pmc The entomological inoculation rate and Plasmodium falciparum infection in African children
    D L Smith
    Fogarty International Center, National Institutes of Health, Building 16, 16 Center Drive, Bethesda, Maryland 20892, USA
    Nature 438:492-5. 2005
    ..The results have important implications for public health interventions: the success of malaria control will depend heavily on whether efforts are targeted at those who are most at risk of infection...
  87. ncbi Mapping the basic reproduction number (R₀) for vector-borne diseases: a case study on bluetongue virus
    N A Hartemink
    Theoretical Epidemiology, Veterinary Medicine, Utrecht, The Netherlands
    Epidemics 1:153-61. 2009
    ....
  88. ncbi Effect of temperature on the development of the aquatic stages of Anopheles gambiae sensu stricto (Diptera: Culicidae)
    M N Bayoh
    School of Biological and Biomedical Sciences Science Laboratories, University of Durham Durham DH1 3LE UK
    Bull Entomol Res 93:375-81. 2003
    ..gambiae s.s. corresponded closely with the best map of malaria risk currently available for Africa...
  89. ncbi Behavioural aspects influencing plant virus transmission by homopteran insects
    Alberto Fereres
    Departamento de Proteccion Vegetal, Consejo Superior de Investigaciones Cientificas CSIC, Centro de Ciencias Medioambientales, Instituto de Ciencias Agrarias, Madrid, Spain
    Virus Res 141:158-68. 2009
    ....
  90. pmc Human exposure to anopheline mosquitoes occurs primarily indoors, even for users of insecticide-treated nets in Luangwa Valley, South-east Zambia
    Aklilu Seyoum
    Liverpool School of Tropical Medicine, Vector Group, Pembroke Place, Liverpool L3 5QA, UK
    Parasit Vectors 5:101. 2012
    ..We studied the human biting behaviour of the malaria vector Anopheles funestus Giles and the potential malaria vector Anopheles quadriannulatus Theobald in Luangwa valley, south-east Zambia...
  91. pmc Fine-scale variation in vector host use and force of infection drive localized patterns of West Nile virus transmission
    Gabriel L Hamer
    Department of Pathobiological Sciences, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 6:e23767. 2011
    ..Rather, robust assessment of local transmission risk should incorporate heterogeneity in vector host feeding and variation in vertebrate reservoir competence at the spatial scale of vector-host interaction...
  92. pmc Development of vegetable farming: a cause of the emergence of insecticide resistance in populations of Anopheles gambiae in urban areas of Benin
    Anges William M Yadouleton
    Centre de Recherche Entomologique de Cotonou, Benin
    Malar J 8:103. 2009
    ..This study aims to assess the rapid expansion of urban agriculture especially, its contribution to the emergence of insecticide resistance in populations of Anopheles gambiae...
  93. ncbi SNP genotyping defines complex gene-flow boundaries among African malaria vector mosquitoes
    D E Neafsey
    Broad Institute, Cambridge, MA 02142, USA
    Science 330:514-7. 2010
    ..Complex genomic differentiation among speciating vector mosquito populations implies that tools for genome-wide monitoring of population structure will prove useful for the advancement of malaria eradication...
  94. pmc Chikungunya virus emergence is constrained in Asia by lineage-specific adaptive landscapes
    Konstantin A Tsetsarkin
    Institute for Human Infections and Immunity, Center for Tropical Diseases and Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Proc Natl Acad Sci U S A 108:7872-7. 2011
    ..albopictus-adapted African strains. These results underscore how different adaptive landscapes occupied by closely related viral genotypes can profoundly affect the outcome of viral evolution and disease emergence...
  95. pmc Induction of a peptide with activity against a broad spectrum of pathogens in the Aedes aegypti salivary gland, following Infection with Dengue Virus
    Natthanej Luplertlop
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Pathog 7:e1001252. 2011
    ..aegypti, but also emphasizes the broad-spectrum anti-pathogenic activity of the immature, signal peptide-containing form of this peptide...
  96. ncbi Role of vector control in the global program to eliminate lymphatic filariasis
    Moses J Bockarie
    Centre for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, United Kingdom
    Annu Rev Entomol 54:469-87. 2009
    ....
  97. pmc Disentangling vector-borne transmission networks: a universal DNA barcoding method to identify vertebrate hosts from arthropod bloodmeals
    Miguel Alcaide
    Estacion Biologica de Donana CSIC, Isla de la Cartuja, Sevilla, Spain
    PLoS ONE 4:e7092. 2009
    ..Such information is crucial to support the efficient management of initiatives aimed at reducing epidemiologic risks of arthropod vector-borne pathogens, a priority for public health...
  98. pmc Revisiting the basic reproductive number for malaria and its implications for malaria control
    David L Smith
    Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Biol 5:e42. 2007
    ..Therefore, strategic planning for malaria control should consider R0, the spatial scale of transmission, human population density, and heterogeneous biting...
  99. pmc Immunity to distinct sand fly salivary proteins primes the anti-Leishmania immune response towards protection or exacerbation of disease
    Fabiano Oliveira
    Vector Molecular Biology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
    PLoS Negl Trop Dis 2:e226. 2008
    ..major infection. Here, we analyze the immune response to distinct salivary proteins from P. papatasi that produced contrasting outcomes of L. major infection...
  100. ncbi Antibody response against saliva antigens of Anopheles gambiae and Aedes aegypti in travellers in tropical Africa
    Eve Orlandi-Pradines
    Unité de recherche en biologie et en épidémiologie parasitaires, Institut de Medecine Tropicale du Service de Sante des Armees, Parc le Pharo, BP 46, 13998 Marseille Armees, France
    Microbes Infect 9:1454-62. 2007
    ..These results suggest that antibody responses to the saliva of mosquitoes could be considered as specific surrogate markers of exposure of travellers to mosquito vectors that transmit arthropod borne infections...
  101. ncbi Does kdr genotype predict insecticide-resistance phenotype in mosquitoes?
    Martin J Donnelly
    Vector Group, Liverpool School of Tropical Medicine, Liverpool L35QA, UK
    Trends Parasitol 25:213-9. 2009
    ..However, we emphasize that kdr genotype might explain only a portion of heritable variation in resistance and that diagnostic assays to test the importance of other resistance mechanisms in field populations are required...

Research Grants63

  1. Genetic Analysis of Mosquito Metamorphosis
    James T Nishiura; Fiscal Year: 2012
    ..Current methods to control these diseases emphasize immunization, chemical prophylaxis, control of the insect vectors, and reduced contact with insect vectors...
  2. Global sumoylation analysis in Trypanosoma brucei
    David A Campbell; Fiscal Year: 2010
    ..of human leishmaniasis, African trypanosomiasis and Chagas disease are transmitted from person to person via insect vectors. The pathogens'protein compositions are distinct in both insect and mammalian stages and needs to change ..
  3. Ultraviolet light sensing by cryptochrome
    Todd C Holmes; Fiscal Year: 2013
    ..Other CRY sequences will become available in the near future for testing the insect vectors for Chagas disease and typhus...
  4. PROTEINASE SYSTEMS IN INSECT HEMOLYMPH
    Michael R Kanost; Fiscal Year: 2013
    ..Such Innate immune responses are likely to affect the outcome of infections of insect vectors with the pathogens and parasites they transmit...
  5. Francisella tularensis Interactions with Airway Epithelial Cells
    THOMAS KAWULA; Fiscal Year: 2009
    ..Human infections result from transmission by insect vectors, direct physical contact with infected animals, ingestion of contaminated food or water, and inhalation of ..
  6. Infection and Immunity K-12 Science Program: Exploring Knowns/Unknowns via VCRC/Q
    Marlys Hearst Witte; Fiscal Year: 2013
    ..coccidioidomycosis, AIDS, influenza;MRSA, wound/surgical infections;parasitic diseases from worms and insect vectors;1 and 2 immune disorders, organ transplantation;vaccines;and bioterrorism;3) provide K-12 teacher training and ..
  7. Conformations and interactions of insect olfactory receptor proteins
    ROBERT D RENTHAL; Fiscal Year: 2010
    ..The results will help provide the basis for future development of methods to control insect vectors through manipulation of the olfactory system...
  8. Analysis of a Large Family of Candidate Taste Receptors
    John R Carlson; Fiscal Year: 2013
    ..Advances in the understanding of taste may lead to new means of controlling these insect vectors of human disease...
  9. Molecular Biology of the Odorant Receptors
    Leslie B Vosshall; Fiscal Year: 2011
    b>Insect vectors of human disease infect hundreds of millions of individuals annually with deadly infectious diseases, including Malaria, Dengue and Yellow Fever, and West Nile Encephalitis...
  10. Bursicon Receptor Antagonists: Templates for Developing Novel Insecticides
    Alan S Kopin; Fiscal Year: 2013
    ..by applicant): The insecticides that are currently used to control populations of disease-transmitting insect vectors act on a highly restricted set of targets...
  11. Analysis of Chemosensory Receptor Genes
    John R Carlson; Fiscal Year: 2013
    ..Advances in the understanding of chemosensory reception may lead to new means of controlling these insect vectors of human disease...
  12. TRANSCRIPTOME ANALYSIS OF LEISHMANIA PANAMENSIS DEVELOPMENTAL STAGES
    Christian Tschudi; Fiscal Year: 2013
    ..cause disease in humans and their epidemiological features involve a considerable range of reservoir hosts and insect vectors, suggesting specific adaptations...
  13. Mosquito Vector Control Using Bt Coupled to Seed Oil Bodies
    Mohd Amir Abdullah; Fiscal Year: 2009
    ..Mosquitoes are the insect vectors for numerous blood-borne human diseases including malaria, West Nile fever, yellow fever, and dengue that ..
  14. Juvenile hormone action, and crosstalk between juvenile hormone and 20-hydroxyecd
    Jinsong Zhu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Mosquitoes are insect vectors responsible for the transmission of many infectious diseases to hundreds of millions of people worldwide...
  15. ACTIONS OF SEMINAL PROTEINS IN MATED DROSOPHILA FEMALES
    MARIANA FEDERICA WOLFNER; Fiscal Year: 2013
    ..genetics to dissect seminal protein function informs the understanding of human fertility and the control of insect vectors of disease...
  16. Initiation and Regulation of Immune Protease Pathways
    Haobo Jiang; Fiscal Year: 2012
    ..In insect vectors of human diseases, initiation and regulation of these protease systems may be disrupted by proteins from the ..
  17. Role of the DSC1 family of cation channels in insect neurophysiology and neurotox
    Chun Fang Wu; Fiscal Year: 2012
    Use of insecticides and repellents to control insect vectors is an important strategy for fighting some of the most devestating human diseases, such as malaria...
  18. Mechanisms of Chikungunya Virus Binding and Entry
    LAURIE SILVA; Fiscal Year: 2013
    ..Due to the high prevalence of the CHIKV insect vectors in many parts of the world, the potential for CHIKV to cause significant epidemics in uninfected regions ..
  19. Elucidating the function of the Lipid-Binding Protein OBI-1 in Pristionchus pacif
    Ray L Hong; Fiscal Year: 2013
    ..This is especially relevant to human health since filarial nematodes also require insect vectors to transmit diseases such as lymphatic filariasis...
  20. Function and organization of the Drosophila pharynx
    RYAN MATTHEW JOSEPH; Fiscal Year: 2013
    ..Thus, uncovering basic principles of taste perception could lead to new methods of controlling insect vectors of disease and managing human dietary regulation.
  21. FLYBASE: A DROSOPHILA GENOMIC AND GENETIC DATABASE
    WILLIAM MARTIN GELBART; Fiscal Year: 2013
    ..and human gene sets and biological processes, allowing Drosophila research to inform studies of human biology and disease, but also because Drosophila melanogaster is the closest model for research on insect vectors of disease.
  22. The role of sand fly saliva in visceralization of Leishmania parasites
    Gregory Lanzaro; Fiscal Year: 2009
    ..These findings have had a profound effect on our understanding of the relationship between insect vectors, the parasites they transmit, and the diseases they cause...
  23. GENETIC AND MOLECULAR ANALYSIS OF OLFACTION
    John R Carlson; Fiscal Year: 2013
    ..The results may also have special implications for the control of insect vectors of disease...
  24. Molecular Targets for Control of Vector-Borne Diseases: Bridging Lab and Field R
    Andrew D Robertson; Fiscal Year: 2010
    ..diseases such as malaria, sleeping sickness, and dengue fever are transmitted from person to person by insect vectors. The vectors are required for transmission, and thus the vector is a potential target for the control of ..
  25. N-GLYCOSYLATION MECHANISM IN INSECT CELLS
    Donald L Jarvis; Fiscal Year: 2010
    ..between insect and mammalian protein /V-glycosylation pathways could reveal ways to interrupt disease transmission by insect vectors or to control agriculturally important insect pests, which would have a major impact on human health.
  26. A novel family of chemoreceptors is expressed in the Drosophila larva
    SHANNON RENE STEWART; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Insect vectors of disease find their human hosts primarily through chemosensory cues. Further, most rely heavily on chemosensation in both larval and adult stages...
  27. Vector-Borne Disease Control in Urban Environments (RMI)
    John C Beier; Fiscal Year: 2006
    ..and natural disasters all contribute to the development of conditions that modify the natural habitats of insect vectors. These complex problems can best be addressed through interdisciplinary approaches, as history has shown that ..
  28. Antiviral Immunity in Mosquitoes
    Kevin M Myles; Fiscal Year: 2013
    ..knowledge of the epidemiology of mosquito-borne viral diseases and also help to assess possibilities for broad spectrum control strategies that are based on manipulating an evolutionary arms race between viruses and their insect vectors.
  29. Rapid Detection and Identification of Zoonotic Pathogens
    John Dunn; Fiscal Year: 2007
    Zoonotic pathogens including those transmitted by insect vectors are some of the most deadly of all infectious diseases known to mankind...
  30. 2009 Annual Meeting of the American Mosquito Control Association
    ROXANNE CONNELLY; Fiscal Year: 2009
    ..Institute of Allergy and Infectious Disease (NIAID) mission as it relates to understanding the biology of insect vectors of disease that will ultimately aid in disease prevention...
  31. INSECT HEME OXYGENASE
    Boris Dunkov; Fiscal Year: 2004
    ..They will provide a tool to study the fate of heme in hematophagous insect vectors of disease, and may lead to the design of novel and effective ways to control insects of medical importance...
  32. INTERFERENCE WITH STEROID RESPONSE GENES IN LEPIDOPTERA
    Lynn Riddiford; Fiscal Year: 2002
    ..information gained also can provide a basis for the rational design of new insect growth regulators to control insect vectors of human disease and avoid possible side effects of these regulators or their environmental degradation ..
  33. SYNTHESIS AND DEGRADATION OF RIBOSOMES IN THE MOSQUITO
    Ann Fallon; Fiscal Year: 2004
    ..undescribed C-terminal similarity to histone H1 protein is shared among two closely related groups of insect vectors. The 5'-flanking sequences of the mosquito rpS6 gene will be compared to those of rpL8 and rpL34, and sites ..
  34. Macrofilaricidal Aminoacyl-tRNA Synthetase Inhibitors
    Michael Kron; Fiscal Year: 2006
    ..and model for future infectious disease therapeutics research to combat the full spectrum of bacterial, fungal, unicellular, and multicellular parasites of man, as well as insect vectors of human disease. [unreadable] [unreadable]
  35. Molecular Basis of Francisella Virulence and Immunity
    THOMAS KAWULA; Fiscal Year: 2005
    ..numerous transmission mechanisms including inhalation, ingestion, skin contact, mucous membrane contact, and insect vectors. Little is known about the mechanisms of F. tularensis pathogenesis and host resistance. F...
  36. PROTEINASE SYSTEMS IN INSECT HEMOLYMPH
    Michael R Kanost; Fiscal Year: 2010
    ..Relevance: Innate immune responses are likely to affect the outcome of infections of insect vectors with the pathogens and parasites they transmit...
  37. SURVIVAL AND EXTINCTION IN RNA VIRUS POPULATIONS
    ISABEL NOVELLA; Fiscal Year: 2003
    ..Specifically, the proposal will address the effect of antibody response and of replication in insect vectors, on virus survival and adaptation.
  38. HTLV-I INFECTION AND ATL
    Miguel Suarez; Fiscal Year: 1992
    ..transmitted through sexual contacts, blood transfusion, sharing of contaminated needles and possibly through insect vectors as well...
  39. REGULATION OF INSECT JUVENILE HORMONE BIOSYNTHESIS
    LINDA RESTIFO; Fiscal Year: 2001
    ..for biorational control agents, and should facilitate the eventual cloning of the homologous enzyme(s) from insect vectors of disease...
  40. ANOPHELES STEPHENSI NO SYNTHASE--IMPACT ON PLASMODIUM
    Shirley Luckhart; Fiscal Year: 2001
    ..will provide new insights into mosquito-parasite biology, provide tools with which to examine NOS in other insect vectors, and perhaps provide a novel basis for engineering Plasmodium-refractory mosquitoes to interrupt the ..
  41. REGULATION OF CECROPIN AND ATTACIN GENE EXPRESSION
    Peter Dunn; Fiscal Year: 1991
    ..This knowledge may contribute to the management of insect vectors of human and animal disease.
  42. REGULATION OF JUVENILE HORMONE SYNTHESIS
    Barbara Stay; Fiscal Year: 2003
    ..The health relatedness is to provide information useful for the development of methods to control insect vectors of disease as well as to contribute to the understanding of fundamental processes of neuroendocrine and ..
  43. Adnesion Receptors of the Insect Immune System
    JAMES NARDI; Fiscal Year: 2003
    ..Understanding the molecular underpinnings of the insect immune response will clearly help in understanding the fate of pathogens in the blood of insect vectors of human diseases.
  44. TRANS-SIALIDASE OF INSECT-DERIVED FORMS OF T CRUZI
    Victor Nussenzweig; Fiscal Year: 1993
    Trypanosoma cruzi is a protozoan that causes Chagas' disease in humans. It divides in th midgut of insect vectors until it transforms into infective metacyclic forms...
  45. ECDYSONE EFFECTS ON MOSQUITO CELL PROLIFERATION
    Ann Fallon; Fiscal Year: 2001
    ..Results of this study will provide novel insights into the effects of 20E on cell growth and proliferation, which are directly relevant to efforts to control vector-borne disease by genetic manipulation of insect vectors.
  46. Action of a Drosophila ovulation-stimulating prohormone
    Laura Sirot; Fiscal Year: 2007
    ..cascade that stimulates insect ovulation and aid in the development of methods to control reproduction of insect vectors of human disease...
  47. MOLECULAR GENETICS OF IMMUNITY IN DROSOPHILA
    John Postlethwait; Fiscal Year: 1992
    ..2) Development of novel methodologies for controlling populations of insect vectors of human disease by blocking insect immunity.
  48. Population dynamics of a bird-borne arbovirus
    Charles Brown; Fiscal Year: 2007
    ..e., colony sites) can be reliably identified and ecological hypotheses tested. ..
  49. A Novel Virus that Infects & Sterilizes Insect Vectors of Human Disease
    Drion Boucias; Fiscal Year: 2008
    ..and biological data on a novel virus group, the salivary gland hypertrophic viruses (SGHVs), which impacts insect vectors of both human and animal diseases...
  50. HOST COMPETENCE FACTORS AFFECT ARBOVIRUS TRANSMISSION
    William Reisen; Fiscal Year: 2003
    ..Studies will assess how alternating sequential infections between vertebrate and vector species that are part of the natural transmission cycle may alter virus genetics and fitness. ..
  51. ARBOVIRUS PERSISTENCE IN SEASONAL WETLANDS
    William Reisen; Fiscal Year: 2002
    ..Virus ecology at wetlands in the Coachella Valley of southeastern California with consistent enzootic activity will be compared with wetlands in the southern San Joaquin Valley where virus activity currently is intermittent. ..
  52. Wolbachia as an Agent for Population Replacement in Anopheles Gambiae
    Jason Rasgon; Fiscal Year: 2008
    ..We propose to evaluate transfer Wolbachia infection into Anopheles gambiae and evaluate the symbiont as a candidate transgene drive system for malaria control. [unreadable] [unreadable] [unreadable]..
  53. HOBO-LIKE ELEMENTS IN INSECTS
    DAVID O BROCHTA; Fiscal Year: 2008
    ..gambiae populations, 3) develop Herves into a mosquito gene vector. These aims will be accomplished by performing a combination of laboratory and field-based studies using molecular and population genetics tools. ..
  54. CHAGAS DISEASE: AUTOIMMUNITY STEMS FROM PARASITE INVASION OF HOST GENOME
    Antonio Teixeira; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  55. Plasmodium vivax:Proteomic Analysis of Asexual and Sporozoite Stages
    Liwang Cui; Fiscal Year: 2007
    ..Its recent resurgence in prevalence and emergence of drug- resistant parasite strains have raised a great concern for the future control of malaria. [unreadable] [unreadable] [unreadable]..
  56. Anti-larval measures for malaria control in The Gambia
    Steven Lindsay; Fiscal Year: 2007
    ..The results from this study will make a major contribution to quantifying the importance of the use of Bs and Bti in the fight against malaria. ..
  57. ECOLOGY AND GENETICS OF VENEZUELAN EQUINE ENCEPHALITIS
    Scott Weaver; Fiscal Year: 2005
    ..This information will be invaluable in targeting prevention and control resources, especially for obtaining maximum benefit in developing countries with limited resources. ..
  58. Malaria sporozoite gene exprssion in the mosquito
    Brenda Beerntsen; Fiscal Year: 2003
    ..Ultimately, this valuable information may be exploited to provide new additions to the arsenal of weapons available to control or eradicate malaria. ..
  59. Salivary Potentiation of Arboviral Infections
    Stephen Higgs; Fiscal Year: 2004
    ..This knowledge may contribute towards the development of a mouse model for human dengue infections. ..
  60. Plasmodium sporozoites and the mosquito
    Brenda Beerntsen; Fiscal Year: 2009
    ....