Genomes and Genes
Summary: Members of the class Arachnida, especially SPIDERS; SCORPIONS; MITES; and TICKS; which transmit infective organisms from one host to another or from an inanimate reservoir to an animate host.
Publications235 found, 100 shown here
- Tick ecology: processes and patterns behind the epidemiological risk posed by ixodid ticks as vectorsS E Randolph
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Parasitology 129:S37-65. 2004..Temperate and tropical patterns will be illustrated with reference mostly to Ixodes ricinus and Rhipicephalus appendiculatus, respectively...
- Prevention of tick-borne diseasesJoseph Piesman
Division of Vector Borne Infectious Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80522, USA
Annu Rev Entomol 53:323-43. 2008..Both new approaches to tick and pathogen control and novel ways of translating research findings into practical control measures are needed to prevent tick-borne diseases in the twenty-first century...
- Host association of Borrelia burgdorferi sensu lato--the key role of host complementKlaus Kurtenbach
Dept of Infectious Disease Epidemiology, Imperial College of Science, Technology and Medicine, St Mary s Campus, Norfolk Place, W2 1PG, London, UK
Trends Microbiol 10:74-9. 2002..We conclude that vertebrate hosts rather than tick species are the key to Lyme borreliosis spirochaete diversity...
- Climate change and the potential for range expansion of the Lyme disease vector Ixodes scapularis in CanadaN H Ogden
Groupe de Recherche en Epidémiologie des Zoonoses et Santé Publique, Faculte de Medecine Veterinaire, Universite de Montreal, Que, Canada
Int J Parasitol 36:63-70. 2006..The geographic range of I. scapularis-borne zoonoses may, therefore, expand significantly northwards as a consequence of climate change this century...
- Investigation of ground level and remote-sensed data for habitat classification and prediction of survival of Ixodes scapularis in habitats of southeastern CanadaN H Ogden
Groupe de Recherche en Epidémiologie des Zoonoses et Santé Publique, Faculte de Medecine Veterinaire, Universite de Montreal, Que, Canada
J Med Entomol 43:403-14. 2006..scapularis populations could establish in more northerly woodland types than those in which they currently exist. Suitable habitats may be detected by ground-level habitat classification, and remote-sensed data may assist this process...
- Tick-host-pathogen interactions in Lyme borreliosisJoppe W R Hovius
University of Amsterdam, Academic Medical Center, Center for Experimental and Molecular Medicine, 1105 AZ Amsterdam, The Netherlands
Trends Parasitol 23:434-8. 2007..Moreover, we discuss how such vector molecules could be used to develop vector-antigen-based vaccines to prevent the transmission of B. burgdorferi and, potentially, other arthropod-borne microbes...
- The range of Ixodes ricinus and the risk of contracting Lyme borreliosis will increase northwards when the vegetation period becomes longerThomas G T Jaenson
Medical Entomology Unit, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
Ticks Tick Borne Dis 2:44-9. 2011..This will lead to an increased Lyme borreliosis risk in northern Scandinavia...
- The brown dog tick, Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae): from taxonomy to controlFilipe Dantas-Torres
Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhaes, Fundacao Oswaldo Cruz, Caixa Postal 7472, Avenida Professor Moraes Rego s n, Campus UFPE, Recife, Pernambuco, Brazil
Vet Parasitol 152:173-85. 2008..sanguineus, highlighting the potential risks associated to the improper use of acaricides, such as environmental pollution and toxicity to humans and other non-target organisms (e.g., tick predators)...
- Longitudinal analysis of tick densities and Borrelia, Anaplasma, and Ehrlichia infections of Ixodes ricinus ticks in different habitat areas in The NetherlandsPeter R Wielinga
Microbiological Laboratory for Health Protection, National Institute for Public Health and the Environment, Antonie van Leeuwenhoeklaan 9, Bilthoven 3720 BA, The Netherlands
Appl Environ Microbiol 72:7594-601. 2006....
- Ecology of Borrelia burgdorferi sensu lato in Europe: transmission dynamics in multi-host systems, influence of molecular processes and effects of climate changeAlessandro Mannelli
University of Torino, Grugliasco, Italy
FEMS Microbiol Rev 36:837-61. 2012....
- A relapsing fever group spirochete transmitted by Ixodes scapularis ticksG A Scoles
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520-8034, USA
Vector Borne Zoonotic Dis 1:21-34. 2001..Considering the frequency of contact between I. scapularis and humans, further work is needed to determine the potential public health significance of yet another zoonotic agent transmitted by this tick species...
- Targeting arthropod subolesin/akirin for the development of a universal vaccine for control of vector infestations and pathogen transmissionJose De La Fuente
Instituto de Investigacion en Recursos Cinegeticos IREC CSIC UCLM JCCM, Ronda de Toledo s n, 13005 Ciudad Real, Spain jose
Vet Parasitol 181:17-22. 2011..However, further research is needed in critical areas towards achieving this goal...
- Spatiotemporal patterns of host-seeking Ixodes scapularis nymphs (Acari: Ixodidae) in the United StatesM A Diuk-Wasser
Department of Epidemiology and Public Health, Yale School of Medicine, 60 College St, New Haven, CT 06520 8034, USA
J Med Entomol 43:166-76. 2006..scapularis-borne Borrelia, which will improve targeting of disease prevention efforts...
- Incidence from coincidence: patterns of tick infestations on rodents facilitate transmission of tick-borne encephalitis virusS E Randolph
Department of Zoology, University of Oxford, UK
Parasitology 118:177-86. 1999..This identifies the particular climatic factors that permit such patterns of tick seasonal dynamics as the primary predictors for the focal distribution of TBE...
- Highly prevalent Coxiella sp. bacterium in the tick vector Amblyomma americanumAlgimantas Jasinskas
Deparetments of Microbiology and Molecular Genetics, University of California Irvine, Pacific Southwest Center, 3012 Hewitt, Irvine, CA 92697 4028, USA
Appl Environ Microbiol 73:334-6. 2007..and a Rickettsia sp. While the Coxiella sp. was detected in 50 of 50 field-collected ticks, the Rickettsia sp. was absent from 32% of ticks. The Coxiella sp. showed evidence of a reduced genome and may be an obligate endosymbiont...
- Seasonal variation in the effect of climate on the biology of Rhipicephalus sanguineus in southern EuropeFilipe Dantas-Torres
Dipartimento di Sanità Pubblica e Zootecnia, Universita degli Studi di Bari, 70010 Valenzano, Bari, Italy
Parasitology 138:527-36. 2011..To date, there have been no investigations on the biology of R. sanguineus under natural Mediterranean climatic conditions...
- Human activities predominate in determining changing incidence of tick-borne encephalitis in EuropeS E Randolph
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom
Euro Surveill 15:24-31. 2010....
- Occurrence of different Borrelia burgdorferi sensu lato genospecies including B. afzelii, B. bavariensis, and B. spielmanii in hedgehogs (Erinaceus spp.) in EuropeJasmin Skuballa
Karlsruhe Institute of Technology, Zoological Institute, Dept of Ecology and Parasitology, Kornblumenstrasse 13, 76131 Karlsruhe, Germany
Ticks Tick Borne Dis 3:8-13. 2012..burgdorferi s.l. genospecies in various habitats. We hypothesise that juvenile or individuals with low immune competence in particular, have a high reservoir potential for the 3 genospecies identified here...
- The increasing recognition of rickettsial pathogens in dogs and peopleWilliam L Nicholson
Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Trends Parasitol 26:205-12. 2010..Newer molecular assays are available, although renewed efforts to encourage their use are needed. This review highlights the ecology and epidemiology of these diseases, and proposes avenues for future investigation...
- Which forest bird species are the main hosts of the tick, Ixodes ricinus, the vector of Borrelia burgdorferi sensu lato, during the breeding season?M Marsot
INRA, UR346, Epidémiologie animale, F 63122 Saint Genes Champanelle, France
Int J Parasitol 42:781-8. 2012..These species, and particularly T. merula which was host to a high proportion of the nymphs, are likely to contribute significantly to the circulation of pathogens for which they are competent, such as the agent of Lyme borreliosis...
- Prospective study on the incidence of infection by Borrelia burgdorferi sensu lato after a tick bite in a highly endemic area of SwitzerlandDelphine Huegli
Institut de Biologie, Laboratoire d Eco Epidémiologie, Universite de Neuchatel, 2000 Neuchatel, Switzerland
Ticks Tick Borne Dis 2:129-36. 2011..9% of nymphs remained attached for more than 24h whereas only 38.3% of female ticks remained attached for more than 24h. We observed that 6.6% and 2.4% of participants bitten by infected and uninfected ticks, respectively, developed EM...
- Population genetics, taxonomy, phylogeny and evolution of Borrelia burgdorferi sensu latoGabriele Margos
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
Infect Genet Evol 11:1545-63. 2011....
- Molecular epidemiology of tick-borne encephalitis virus in Ixodes ricinus ticks in LithuaniaXiuqi Han
Department of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland
J Med Virol 77:249-56. 2005..The NS5 sequences, although identical within one locality, did not show any mutations common to strains from the two Lithuanian regions, nor could any geographical clustering be found among western type TBEV strains from other areas...
- Microclimate and the zoonotic cycle of tick-borne encephalitis virus in SwitzerlandC Burri
Institute of Biology, Laboratory of Eco Epidemiology of Parasites, University of Neuchatel, Emile Argand 11, 2000 Neuch and tel, Switzerland
J Med Entomol 48:615-27. 2011..The proportion of hosts with cofeeding ticks seemed to be one of the factors that distinguished a TBEV focus from a non-TBEV focus. The enzootic cycle of TBEV might be disrupted when dry and hot springs occur during consecutive years...
- Ticks (Ixodidae) on humans in South AmericaA A Guglielmone
Instituto Nacional de Tecnologia Agropecuaria, Estacion Experimental Agropecuaria Rafaela, CC 22, CP 2300, Rafaela, Santa Fe, Argentina
Exp Appl Acarol 40:83-100. 2006..Indeed, there is only one record of an Ixodes collected while feeding on man for all South America...
- Prevalence of Borrelia burgdorferi sensu lato in ticks collected from migratory birds in SwitzerlandPoupon Marie-Angèle
Institute of Zoology, Emile Argand 11, 2007 Neuchâtel 7, Switzerland
Appl Environ Microbiol 72:976-9. 2006..Among birds infested by infected ticks, 23% (6/26) were infested by B. lusitaniae-infected larvae. Migratory birds appear to be reservoir hosts for B. lusitaniae...
- Prevalence of tick-borne encephalitis virus in Ixodes ricinus and Dermacentor reticulatus ticks collected from the Lublin region (eastern Poland)Angelina Wójcik-Fatla
Unit of Zoonoses, Institute of Agricultural Medicine, Lublin, Poland
Ticks Tick Borne Dis 2:16-9. 2011..The minimum infection rate of I. ricinus ticks with TBEV amounted to 1.6% while the infection rate of D. reticulatus ticks was 10.8%. The results suggest that D. reticulatus may be a potential vector of TBEV in Central Europe...
- Characterization of tick-borne encephalitis virus from EstoniaIrina Golovljova
National Institute for Health Development, Tallinn, Estonia
J Med Virol 74:580-8. 2004..In the 3'-NCR sequence of the Estonian strain Est2546, which belonged to the FE-TBEV subtype, a deletion from position 10461 to 10810 extending approximately 10 nucleotides into the core element, was detected...
- Impact of host community composition on Lyme disease riskKathleen LoGiudice
Department of Biological Sciences, Union College, Schenectady, New York 12308, USA
Ecology 89:2841-9. 2008..This underscores the importance of constructing interaction webs for vertebrates and exploring the direct and indirect effects of anthropogenic stressors on host community composition...
- Vaccination against ticks (Boophilus spp.): the experience with the Bm86-based vaccine GavacJ de la Fuente
Division of Mammalian Cell Genetics, Centro de Ingenieria Genetica y Biotecnologia, Havana, Cuba
Genet Anal 15:143-8. 1999..4 dollars animal(-1) year (-1). These results clearly demonstrate the advantage of vaccination and support the application of Gavac for the control of Boophilus spp. infestations...
- Epidemiology and ecology of TBE relevant to the production of effective vaccinesJochen Süss
Federal Institute for Risk Assessment, National Reference Laboratory for Tick Borne Diseases, Diedersdorfer Weg 1, D 12277 Berlin, Germany
Vaccine 21:S19-35. 2003..Therefore the review is a basis for travellers and inhabitants to get background information for their personal risk assessment...
- Fucosylation enhances colonization of ticks by Anaplasma phagocytophilumJoao H F Pedra
Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
Cell Microbiol 12:1222-34. 2010..Our results uncover a novel mechanism of pathogen colonization in arthropods. Decoding mechanisms of pathogen invasion in ticks might expedite the development of new strategies to interfere with the life cycle of A. phagocytophilum...
- Rickettsia parkeri rickettsiosis and its clinical distinction from Rocky Mountain spotted feverChristopher D Paddock
Infectious Diseases Pathology Branch, Mailstop G 32, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30333, USA
Clin Infect Dis 47:1188-96. 2008..parkeri and comment on distinctions between R. parkeri rickettsiosis and other United States rickettsioses...
- Geographic and temporal variations in population dynamics of Ixodes ricinus and associated Borrelia infections in The NetherlandsFedor Gassner
Laboratory of Entomology, Wageningen University and Research Centre, Wageningen, The Netherlands
Vector Borne Zoonotic Dis 11:523-32. 2011..The study shows that Borrelia-infected ticks are present in many forest and dune areas in The Netherlands and suggests that in such biotopes, which are used for a wide variety of recreational activities, the infection risk is high...
- Life cycle of Hepatozoon canis (Apicomplexa: Adeleorina: Hepatozoidae) in the tick Rhipicephalus sanguineus and domestic dog (Canis familiaris)Gad Baneth
School of Veterinary Medicine, Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel
J Parasitol 93:283-99. 2007..Skeletal pain and recumbency were manifested in 2 dogs. This study further elucidates the life cycle of H. canis and provides a sequential morphologic description of H. canis merogony, gamontogony, and sporogony...
- Potential effects of mixed infections in ticks on transmission dynamics of pathogens: comparative analysis of published recordsHoward S Ginsberg
USGS Patuxent Wildlife Research Center, Coastal Field Station, Woodward Hall PLS, University of Rhode Island, Kingston, RI 02881, USA
Exp Appl Acarol 46:29-41. 2008..In contrast, when the number of tick bites is high (e.g., for wild animal hosts) changes in pathogen prevalence in ticks have relatively little effect on levels of transmission to reservoir hosts, and thus on natural transmission cycles...
- Tick anti-hemostatics: targets for future vaccines and therapeuticsChristine Maritz-Olivier
Department of Biochemistry, University of Pretoria, Pretoria, 0002, South Africa
Trends Parasitol 23:397-407. 2007..This review aims to summarize the key features of tick anti-hemostatics, their structures, mode of action and possible future application as vaccines and novel therapeutic agents...
- Identification of midgut and salivary glands as specific and distinct barriers to efficient tick-borne transmission of Anaplasma marginaleMassaro W Ueti
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
Infect Immun 75:2959-64. 2007..These results establish that there are at least two specific barriers to efficient tick-borne transmission, the midgut and salivary glands, and highlight the complexity of the pathogen-tick interaction...
- Genetic characterization of tick-borne flaviviruses: new insights into evolution, pathogenetic determinants and taxonomyGilda Grard
Unité des Virus Emergents EA3292, IFR48, IRD UR0178, Faculté de médecine La Timone, 27 Boulevard Jean Moulin, 13005 Marseille, France
Virology 361:80-92. 2007..Ticks that feed on both categories of vertebrates may constitute the evolutionary bridge between the three distinct identified lineages...
- The dog as a sentinel for human infection: prevalence of Borrelia burgdorferi C6 antibodies in dogs from southeastern and mid-Atlantic StatesAshlee W Duncan
Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine NCSU CVM, Raleigh, North Carolina 27606, USA
Vector Borne Zoonotic Dis 5:101-9. 2005..Furthermore, they support the utility of dogs as a sentinel to characterize the risk of B. burgdorferi transmission to humans in a defined geographical location...
- Transport of Ixodes ricinus infected with Borrelia species to Norway by northward-migrating passerine birdsGunnar Hasle
Dept of Biology, University of Oslo, P O Box 1050 Blindern, N 0316 Oslo, Norway
Ticks Tick Borne Dis 2:37-43. 2011..The prevalence of the different Borrelia species in ticks collected from migratory birds may be related to migration routes...
- Effectiveness of Metarhizium anisopliae (Deuteromycetes) against Ixodes scapularis (Acari: Ixodidae) engorging on Peromnyscus leucopusV L Hornbostel
Institute of Ecosystem Studies, Box AB Route 44A, Millbrook, NY 12754 5 0129, USA
J Vector Ecol 30:91-101. 2005....
- Migratory songbirds disperse ticks across Canada, and first isolation of the Lyme disease spirochete, Borrelia burgdorferi, from the avian tick, Ixodes auritulusMuhammad G Morshed
Laboratory Services, British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada V5Z 4R4
J Parasitol 91:780-90. 2005..burgdorferi-infected ticks and increased risk of Lyme disease exposure...
- The rising challenge of Lyme borreliosis in CanadaN H Ogden
Foodborne, Waterborne and Zoonotic Infections Division, Public Health Agency of Canada, St Hyacinthe, Quebec, Canada
Can Commun Dis Rep 34:1-19. 2008
- Vector seasonality, host infection dynamics and fitness of pathogens transmitted by the tick Ixodes scapularisN H Ogden
Faculte de Medecine Veterinaire, Universite de Montreal, C P 5000, Saint Hyacinthe, QC, J2S 7C6, Canada
Parasitology 134:209-27. 2007..scapularis-borne microparasites in northeastern North America due to abiotic forcings influencing I. scapularis seasonality...
- Amblyomma triste Koch, 1844 (Acari: Ixodidae): hosts and seasonality of the vector of Rickettsia parkeri in UruguayJ M Venzal
Departamento de Parasitología Veterinaria, Facultad de Veterinaria, Universidad de la Republica, Av Alberto Lasplaces 1620, CP 11600 Montevideo, Uruguay
Vet Parasitol 155:104-9. 2008..The main animal host for adult A. triste at our study sites was the domestic dog. Humans were afflicted by the tick in rural and suburban settlements where other host animals are scarce or extinct and where dogs are common...
- Transport of Babesia venatorum-infected Ixodes ricinus to Norway by northward migrating passerine birdsGunnar Hasle
Reiseklinikken Oslo Travel Clinic, St Olavs plass 3, 0165 Oslo, Norway
Acta Vet Scand 53:41. 2011..venatorum have been described. The objective of this study was to determine whether birds can introduce Babesia-infected ticks. There are between 30 and 85 million passerine birds that migrate to Norway every spring...
- Molecular characterization of tick-virus interactionsPatricia A Nuttall
NERC Centre for Ecology and Hydrology, Maclean Building, Crowmarsh Gifford, Wallingford, OX108BB, United Kingdom
Front Biosci (Landmark Ed) 14:2466-83. 2009..As the tick proteome is unravelled, its interaction with the viral proteome should help explain the interactions between ticks and the many important viruses they transmit...
- TBE incidence versus virus prevalence and increased prevalence of the TBE virus in Ixodes ricinus removed from humansJochen Süss
National Reference Laboratory for Tick Borne Diseases, Friedrich Loeffler Institute, Federal Research Institute for Animal Health, Naumburger Strasse 96a, D 07743 Jena, Germany
Int J Med Microbiol 296:63-8. 2006..6% and in the district of Freyung-Grafenau with 18.3%. In recent studies on unfed I. ricinus (nymphs, adults), the average TBEV prevalence in ticks in Bavarian risk areas was between 0.5% and 2%...
- Detection of Borrelia burgdorferi Sensu Lato and Anaplasma phagocytophilum in small mammals and ectoparasites in HungaryKrisztina Rigó
Department of Parasitology and Zoology, Faculty of Veterinary Science, Szent Istvan University, Budapest, Hungary
Vector Borne Zoonotic Dis 11:1499-501. 2011..57%, 0.06%, and 0.19% for A. phagoctyophilum, B. afzelii, and Borrelia garinii, respectively, in questing ticks). The present study is the first report of borreliae from I. acuminatus and H. concinna from Hungary...
- Failure of the Amblyomma cajennense nymph to become infected by Theileria equi after feeding on acute or chronically infected horsesMúcio F B Ribeiro
Departamento de Parasitologia, ICB UFMG, Belo Horizonte, Av Antonio Carlos, 6627 Belo Horizonte, Minas Gerais, Brazil
Exp Parasitol 128:324-7. 2011..Histopathological analysis failed to detect sporoblast and sporozoites of T. equi in salivary gland acini. This study was not able to observe infection of the A. cajennense by T. equi...
- Ticks as vectors of Leishmania parasitesFilipe Dantas-Torres
Dipartimento di Sanità Pubblica e Zootecnia, Facolta di Medicina Veterinaria, Universita degli Studi di Bari, Str Prov per Casamassima Km 3, 70010 Valenzano, Bari, Italy
Trends Parasitol 27:155-9. 2011..In this article, the role of brown dog ticks, Rhipicephalus sanguineus, as vectors of L. infantum is discussed, and the need for further research to better understand their participation in the epidemiology of leishmaniasis is advocated...
- Prevalence of Borrelia burgdorferi sensu lato in Ixodes ricinus ticks (Acari, Ixodidae) in different Polish woodlandsJ Stanczak
Department of Tropical Parasitology, Institute of Maritime and Tropical Medicine, Powstania Styczniowego 9B, 81 519 Gdynia, Poland
Ann Agric Environ Med 6:127-32. 1999..5%. The obtained results confirmed that B. burgdorferi s.l. is present throughout the distributional areas of I. ricinus in Poland and that a prevalence of spirochete-infected ticks may be high in some locations...
- Dermacentor variabilis and boophilus microplus (Acari: Ixodidae): experimental vectors of Babesia equi to equidsDavid Stiller
J Med Entomol 39:667-70. 2002..variabilis and adult B. microplus, tick species that occur on equids in North America and, in the case of the latter tick, also extensively in tropical and subtropical regions of the world, may be competent natural vectors of B. equi..
- Matrix-assisted laser desorption ionization-time of flight mass spectrometry for rapid identification of tick vectorsAmina Yssouf
Aix Marseille Universite, Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes, UM63, CNRS 7278, IRD 198, INSERM 1095, WHO Collaborative Center for Rickettsioses and Other Arthropod Borne Bacterial Diseases, Faculte de Medecine, Marseille, France
J Clin Microbiol 51:522-8. 2013....
- Birds and BorreliaPierre François Humair
Institut de Zoologie, Universite de Neuchatel, Switzerland
Int J Med Microbiol 291:70-4. 2002..uriae and seabirds. Migrating birds contribute to the spread of B. burgdorferi sl and of infected tick vectors along migration routes...
- Why is tick-borne encephalitis increasing? A review of the key factors causing the increasing incidence of human TBE in SwedenThomas G T Jaenson
Medical Entomology Unit, Department of Systematic Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, Uppsala SE 752 36, Sweden
Parasit Vectors 5:184. 2012..Precipitation during June and July was rich and will lead to a "good mushroom season". These factors together are likely to result in a TBE incidence of 2012 similar to or higher than that of 2011...
- Comparative vector competence of Dermacentor variabilis and Ixodes scapularis (Acari: Ixodidae) for the agent of human granulocytic ehrlichiosisF des Vignes
Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06520 8034, USA
J Med Entomol 36:182-5. 1999..Evidence of transmission was not observed in any of 9 mice exposed to D. variabilis nymphs. These results demonstrate that although I. scapularis is a competent vector of the agent of the HGF, D. variabilis is not...
- Ticks feeding on humans: a review of records on human-biting Ixodoidea with special reference to pathogen transmissionA Estrada-Pena
Departamento de Parasitologia, Facultad de Veterinaria, Miguel Servet, Zaragoza, Spain
Exp Appl Acarol 23:685-715. 1999..Finally, despite the fact that most people who are bitten destroy the offending tick in disgust, it is recommended that they preserve specimens in ethanol for taxonomic identification and detection of pathogens by molecular methods...
- Infection rates of Amblyomma americanum and Dermacentor variabilis by Ehrlichia chaffeensis and Ehrlichia ewingii in southwest MissouriJohn G Steiert
Department of Biology, Southwest Missouri State University, Springfield, MO 65804, USA
Vector Borne Zoonotic Dis 2:53-60. 2002..4% in adult A. americanum (31 of 579) and 3.3% of D. variabilis ticks (four of 120). A minimum infection rate for nymph pools of A. americanum was 1.7% for E. chaffeensis and 0.6% for E. ewingii...
- PCR detection of granulocytic Anaplasma and Babesia in Ixodes ricinus ticks and birds in west-central PolandBogumiła Skotarczak
Departament of Genetics, Faculty of Biology, Szczecin University, al Piastow 40b, 71 065 Szczecin, Poland
Ann Agric Environ Med 13:21-3. 2006..In spite of the high level of infestation of birds by I. ricinus, it is clear that they do not constitute a competent reservoir of A. phagocytophilum and Babesia in WNP. Additionally, I. ricinus is not a significant vector in this area...
- Rickettsia parkeri in BrazilIara Silveira
University of Sao Paulo, Sao Paulo, Brazil
Emerg Infect Dis 13:1111-3. 2007..An R. parkeri isolate was successfully established in Vero cell culture. Molecular characterization of the agent was performed by DNA sequencing of portions of the rickettsial genes gltA, htrA, ompA, and ompB...
- Isolation of tick-borne encephalitis viruses from wild rodents, South KoreaSu Yeon Kim
Division of Arboviruses, Center for Immunology and Pathology, National Institute of Health, Korea Centers for Disease Control and Prevention, Eunpyung Gu, Seoul, Republic of Korea
Vector Borne Zoonotic Dis 8:7-13. 2008..Phylogenetic analysis showed that the E genes of the TBEV isolates were clustered with the Western subtype (98% identity). This study suggests the possible occurrence of tick-borne encephalitis in Korea...
- Detection of a Borrelia miyamotoi sensu lato relapsing-fever group spirochete from Ixodes pacificus in CaliforniaJeomhee Mun
Division of Insect Biology, 201 Wellman Hall, University of California, Berkeley, CA 94720 3112, USA
J Med Entomol 43:120-3. 2006..Phylogenetic analysis based on these two genes revealed that the borreliae detected in these ticks belong to the relapsing-fever group and that these are closely related to, if not identical with, B. miyamotoi...
- Bloodstream- versus tick-associated variants of a relapsing fever bacteriumT G Schwan
Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Science 280:1938-40. 1998..After tick-bite transmission back to mice, the process was reversed and the spirochetes resumed expression of the same Vmp present in the previous infectious blood meal...
- Dissemination of spotted fever rickettsia agents in Europe by migrating birdsKarin Elfving
Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
PLoS ONE 5:e8572. 2010..In conclusion, migratory passerine birds host epidemiologically important vector ticks and Rickettsia species and contribute to the geographic distribution of spotted fever rickettsial agents and their diseases...
- Prevalence of tick-borne encephalitis virus in ticks from southern KoreaSungjin Ko
Veterinary Internal Medicine, Research Institute and BK21 Program for Veterinary Science and College of Veterinary Medicine, Seoul National University, Seoul 151 742, Korea
J Vet Sci 11:197-203. 2010..4% identity, respectively). The Western subtype of TBEV is endemic in Korea, including Jeju Island. The study of vector and zoonotic host susceptibility to TBEV is required to better understand its potential impact on public health...
- Adaptation of Borrelia burgdorferi in the vector and vertebrate hostUtpal Pal
Room 525A, Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520 8031, USA
Microbes Infect 5:659-66. 2003..We also discuss the regulatory mechanisms linked with the development of molecular adaptation of spirochetes within different host environments...
- Borrelia burgdorferi sensu lato, the agent of lyme borreliosis: life in the wildsL Gern
Institute of Biology, University of Neuchatel, Switzerland, Emile Argand 11, Case Postale 158, 2009 Neuchatel, Switzerland
Parasite 15:244-7. 2008..Recent studies confirmed trends toward specific association between Borrelia species and particular host, but also suggested that loose associations may be more frequent in transmission cycles in nature than previously thought...
- Co-detection of Bartonella henselae, Borrelia burgdorferi, and Anaplasma phagocytophilum in Ixodes pacificus ticks from California, USAKevin Holden
Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California, Davis, California 95616, USA
Vector Borne Zoonotic Dis 6:99-102. 2006..98%) with Anaplasma phagocytophilum. Detection of B. henselae was not dependent on co-infection. The present study offers additional evidence that Ixodes spp. ticks may act as hosts and possibly vectors for B. henselae...
- Tick-borne diseases in North Carolina: is "Rickettsia amblyommii" a possible cause of rickettsiosis reported as Rocky Mountain spotted fever?Charles S Apperson
Department of Entomology, North Carolina State University, Raleigh, North Carolina 27695 7647, USA
Vector Borne Zoonotic Dis 8:597-606. 2008..amblyommii" infection for lone star ticks. We propose that some cases of rickettsiosis reported as RMSF may have been caused by "R. amblyommii" transmitted through the bite of A. americanum...
- Impact of climatic change on the northern latitude limit and population density of the disease-transmitting European tick Ixodes ricinusE Lindgren
Natural Resources Management, Department of Systems Ecology, Stockholm University, Stockholm, Sweden
Environ Health Perspect 108:119-23. 2000..We conclude that the relatively mild climate of the 1990s in Sweden is probably one of the primary reasons for the observed increase of density and geographic range of I. ricinus ticks...
- Characterization of an endosymbiont infecting wood ticks, Dermacentor andersoni, as a member of the genus FrancisellaM L Niebylski
Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
Appl Environ Microbiol 63:3933-40. 1997..Transovarial transmission to female progeny was 95.6%, but we found no evidence of horizontal transmission...
- Biology of infection with Borrelia burgdorferiKit Tilly
Laboratory of Zoonotic Pathogens, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA
Infect Dis Clin North Am 22:217-34, v. 2008..This article describes the basic biology of B burgdorferi and reviews some of the bacterial components required for infection of and survival in the mammalian and tick hosts...
- Fundamental processes in the evolutionary ecology of Lyme borreliosisKlaus Kurtenbach
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK
Nat Rev Microbiol 4:660-9. 2006..burgdorferi s.l. populations. Additionally, we highlight possible epidemiological parallels between B. burgdorferi s.l. and other vector-borne zoonotic pathogens, including West Nile virus...
- Diversity and distribution of Borrelia hermsiiTom G Schwan
National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA
Emerg Infect Dis 13:436-42. 2007..B. hermsii produced a detectable spirochetemia in 1 chicken inoculated subcutaneously. Additional work is warranted to explore the role of birds as enzootic hosts for this relapsing fever spirochete...
- Ticks, Lyme disease spirochetes, trypanosomes, and antibody to encephalitis viruses in wild birds from coastal Georgia and South CarolinaL A Durden
Institute of Anthropodology and Parasitology, Georgia Southern University, Statesboro 30460, USA
J Parasitol 83:1178-82. 1997..burgdorferi...
- Meta-analysis of coinfection and coexposure with Borrelia burgdorferi and Anaplasma phagocytophilum in humans, domestic animals, wildlife, and Ixodes ricinus-complex ticksNathan C Nieto
Department of Medicine and Epidemiology, University of California, Davis, CA, USA
Vector Borne Zoonotic Dis 9:93-102. 2009..We confirm a considerable level of coinfection and coexposure with these pathogens, although not predictably across host or tick species or geographical region...
- Co-circulating microorganisms in questing Ixodes scapularis nymphs in MarylandKatherine I Swanson
W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Vector Ecol 32:243-51. 2007..burgdorferi in I. scapularis in Maryland and demonstrates that Rickettsia spp. and B. burgdorferi circulate independently and at nearly equal frequencies, while A. phagocytophilum and other unrecognized organisms are less common...
- Reptile infection with Anaplasma phagocytophilum, the causative agent of granulocytic anaplasmosisNathan C Nieto
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California 95616, USA
J Parasitol 95:1165-70. 2009..Our findings suggest that lizards and snakes are exposed to A. phagocytophilum by infected ticks, but that they do not serve as primary reservoir hosts of this rickettsia...
- Endosymbionts of ticks and their relationship to Wolbachia spp. and tick-borne pathogens of humans and animalsH Noda
National Institute of Sericultural and Entomological Science, Ibaraki, Japan
Appl Environ Microbiol 63:3926-32. 1997..The two symbionts that live in the Malpighian tubules, one closely related to C. burnetii and the other closely related to F. tularensis, appear to be of ancient origin and be widely distributed in ticks...
- Borrelia burgdorferi and the causative agent of human granulocytic ehrlichiosis in deer ticks, DelawareK L Curran
Department of Biology, Wesley College, Dover, Delaware 19901, USA
Emerg Infect Dis 6:408-11. 2000..Ticks were tested for Borrelia burgdorferi and the causative agent of human granulocytic ehrlichiosis. Infection rates remained stable in New Castle and Kent counties, but increased from <1% to 8% in sussex county...
- Detection of Anaplasma phagocytophilum and Babesia odocoilei DNA in Ixodes scapularis (Acari: Ixodidae) collected in IndianaFresia E Steiner
Department of Physiology and Health Science, Ball State University, Muncie, IN 47306, USA
J Med Entomol 43:437-42. 2006..phagocytophilum and three ticks (20%) were positive for Babesia sp. One was confirmed as B. odocoilei. One tick was coinfected. This is the first report of the presence of these two agents in ticks in Indiana...
- Investigations on the mode and dynamics of transmission and infectivity of Borrelia burgdorferi sensu stricto and Borrelia afzelii in Ixodes ricinus ticksMara Crippa
Institut de Zoologie, University of Neuchatel, Switzerland
Vector Borne Zoonotic Dis 2:3-9. 2002..This study also shows that B. afzelii is transmitted by I. ricinus to the host earlier than B. burgdorferi ss and that I. ricinus seems to be a more efficient vector of B. afzelii than B. burgdorferi ss...
- Hepatozoon kisrae n. sp. infecting the lizard Agama stellio is transmitted by the tick Hyalomma cf. aegyptiumI Paperna
Department of Animal Sciences, Faculty of Agricultural, Food and Environmental Sciences, Hebrew University of Jerusalem, Rehovot 76 100, Israel
Parasite 9:17-27. 2002..Ticks become infected when fed on infected lizards; sporogony was complete when the ticks reached adult stage, over 40 days after initial attachment...
- Anaplasmataceae and Borrelia burgdorferi sensu lato in the sand lizard Lacerta agilis and co-infection of these bacteria in hosted Ixodes ricinus ticksAnna Ekner
Department of Behavioural Ecology, Adam Mickiewicz University, Umultowska 89, 61 614 Poznan, Poland
Parasit Vectors 4:182. 2011..Anaplasmataceae and Borrelia burgdorferi s.l. are important tick-borne bacteria maintained in nature by transmission between ticks and vertebrate hosts. However, the potential role of lizards as hosts has not been sufficiently studied...
- Complement evasion by Borrelia burgdorferi: it takes three to tangoSteven W de Taeye
Center for Experimental and Molecular Medicine, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
Trends Parasitol 29:119-28. 2013..These interactions with complement can be host species-specific. This review provides an overview of interactions between Borrelia, tick, and host leading to evasion of complement-mediated killing...
- [Some biological features of Hyalomma marginatum in the laboratory]Bayram Ali Yukari
Mehmet Akif Ersoy Universitesi, Parazitoloji Anabilim Dali, Burdur, Turkey
Turkiye Parazitol Derg 35:40-2. 2011..This study has been planned to investigate some biological features of Hyalomma marginatum, which is one of the important vectors in the world and in our country...
- Elimination of Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and Ixodes scapularis ticks using a doxycycline hyclate-laden baitMarc C Dolan
Division of Vector Borne Diseases, Bacterial Disease Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado 80521, USA
Am J Trop Med Hyg 85:1114-20. 2011..Results from this study indicate that doxycycline-impregnated bait is an effective means of reducing infection rates for B. burgdorferi and A. phagocytophilum in both rodent reservoirs and questing I. scapularis ticks...
- Long-term occurrence of Hemolivia cf. mauritanica (Apicomplexa: Adeleina: Haemogregarinidae) in captive Testudo marginata (Reptilia: Testudinidae): evidence for cyclic merogony?P Siroky
Department of Biology and Wildlife Diseases, University of Veterinary and Pharmaceutical Sciences, Palackeho 1 3, 612 42 Brno, Czech Republic
J Parasitol 90:1391-3. 2004....
- Evaluation of an in vitro method to measure behavioural diapause in the tick Rhipicephalus appendiculatus (Acarina: Ixodidae) in the laboratoryM Madder
Institute of Tropical Medicine, Department of Animal Health, Antwerpen, Belgium
Parasitology 115:97-100. 1997..Comparable results were obtained with both methods...
- Progress in development of vaccine against Hyalomma anatolicum anatolicum-Indian scenarioS Ghosh
Indian Veterinary Research Institute, Izatnagar 243122, Bareilly, Uttar Pradesh, India
Vaccine 26:G40-7. 2008..a. anatolicum was found to have some adverse effect on development of Theileria annulata in the vector tick. The progress in the development of immunoprophylactic measures against H. a. anatolicum is discussed...
- Persistent infection in Neotoma fuscipes (Muridae: Sigmodontinae) with Ehrlichia phagocytophila sensu latoM B Castro
Vector-Borne Disease Section, Division of Communicable Disease Control, California Department of Health Services, Santa Rosa 95404, USA
Am J Trop Med Hyg 65:261-7. 2001..phagocytophila. Borrelia burgdorferi, the agent of Lyme disease, was cultured from ear punch biopsies from six of seven E. phagocytophila seropositive and one of four seronegative wood rats...
- Reduction of Theileria annulata infection in ticks fed on calves immunized with purified larval antigens of Hyalomma anatolicum anatolicumG Das
Division of Parasitology, Indian Veterinary Research Institute, Izatnagar 243 122 UP, India
Trop Anim Health Prod 37:345-61. 2005..The results suggest a partial reduction in growth rate of T. annulata in ticks feeding on calves immunized with GHLAgP...
- Investigating the epidemiology of heartwater (Cowdria ruminantium infection) by means of a transmission dynamics modelC J O'Callaghan
Department of Biological Sciences, University of Warwick, Coventry, UK
Parasitology 117:49-61. 1998..Model limitations and future developments are discussed. The essential role of a transmission dynamics model in assessing the impact of new vaccines in conjunction with vector control programmes is highlighted...
- Differential transmission of the genospecies of Borrelia burgdorferi sensu lato by game birds and small rodents in EnglandK Kurtenbach
Department of Zoology, University of Oxford, United Kingdom
Appl Environ Microbiol 64:1169-74. 1998..Wildlife management may have an influence on the relative risk of different clinical forms of Lyme borreliosis...
- Borrelia burgdorferi population kinetics and selected gene expression at the host-vector interfaceEmir Hodzic
Center for Comparative Medicine, School of Medicine, University of California at Davis, Davis, California 95616, USA
Infect Immun 70:3382-8. 2002..Evidence of ospA transcription in skin could be found 1 day after tick attachment but not thereafter...
- Transstadial and transovarial persistence of Babesia divergens DNA in Ixodes ricinus ticks fed on infected blood in a new skin-feeding techniqueS Bonnet
UMR ENVN INRA 1034, Ecole Nationale Veterinaire de Nantes, Interactions Hôte Parasite Milieu, Atlanpole La Chantrerie, B P 40706, 44307 Nantes Cedex 03, France
Parasitology 134:197-207. 2007..ricinus via membrane as well as in vitro transmission of B. divergens to its vector. The opportunities offered by the use of such a transmission model of a pathogen by I. ricinus are discussed...
- Seasonal dynamics of Anaplasma phagocytophila in a rodent-tick (Ixodes trianguliceps) system, United KingdomKevin J Bown
Department of Veterinary Clinical Science and Animal Husbandry, Leahurst, University of Liverpool, Chester High Road, Neston, UK
Emerg Infect Dis 9:63-70. 2003..This study confirms that woodland rodents can maintain A. phagocytophila in Great Britain in the absence of other reservoir hosts and suggests that I. trianguliceps is a competent vector...
- Biology of ticksJohn F Anderson
The Connecticut Agricultural Experiment Station, New Haven, CT 06504, USA
Infect Dis Clin North Am 22:195-215, v. 2008..Key factors, including the reversion of agricultural lands to forests and a close association between people and ticks, have greatly increased the risk of tick bite and human disease...
- Tick immunobiologyM Brossard
Institute of Zoology, University of Neuchatel, Emile Argand 11, CH 2007, Neuchatel, Switzerland
Parasitology 129:S161-76. 2004....
- LYME DISEASE IN WESTERN USA: ECOLOGY AND EPIDEMIOLOGYRobert Lane; Fiscal Year: 2008..Development of this risk model, which culminates over 2 decades of intensive study, should contribute significantly to our knowledge of the landscape ecology and epidemiology of LD in this region. ..
- Neutrophil gene expression induced by A. phagocytophilaErol Fikrig; Fiscal Year: 2004..phagocytophila uses to interfere with neutrophil differentiation and function ..
- Immunopathogenesis of Human Granulocytic AnaplasmosisErol Fikrig; Fiscal Year: 2008..phagocytophilum are important in infection, delineate the similarities and differences between infection in the arthropod vector and mammalian host, and lead to new strategies to interfere with the Anaplasma life cycle. ..
- Toll-like receptor responses to West Nile virusErol Fikrig; Fiscal Year: 2007..These studies should increase our understanding of the role of TLR3 in viral recognition, and may lead to new strategies to prevent, or treat, WN virus infection. [unreadable] [unreadable]..
- Tissue Specific Borrelia Gene ExpessionErol Fikrig; Fiscal Year: 2005....
- Early tick salivary antigens as vaccine targetsSukanya Narasimhan; Fiscal Year: 2006..Results obtained will provide the basis for future vaccine development studies. [unreadable] [unreadable] [unreadable]..
- Transmission of Ehrlichia chaffeensis by Adult TicksROGER STICH; Fiscal Year: 2006..chaffeensis and perhaps other closely related pathogens among human and domestic hosts. ..
- Generation of babesial surface protein diversitySHAWN BERENS; Fiscal Year: 2006..The sponsors collaborate closely in research and have successfully mentored clinicians, graduate students, and post-doctoral fellows to research independence. ..
- Assessing Community-Based Tick Control for LD MitigationThomas Mather; Fiscal Year: 2007..Efforts will focus on identifying strategiesfor engaging the community and individuals at risk. ..
- HEALTH BURDERN OF COINFECTING DEER ASSOCIATED ZOONOSESPeter Krause; Fiscal Year: 2001..The density of deer will be estimated in each site. This proposed effort will help define the health burden imposed on people residing in proximity to deer and will contribute to diagnosis and case-management of apparent Lyme disease. ..
- New genetic approaches analyzing Borrelia burgdorferiJon Blevins; Fiscal Year: 2007..This proposal thus seeks to contribute major new advances to borrelial genetics and to use those developments to examine potentially novel aspects of Bb virulence expression. [unreadable] [unreadable]..
- Topical Antibiotics to Prevent Lyme DiseaseGary Wormser; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- 5th Comparative Medicine Resource Center Director Mtg.Stephen Barthold; Fiscal Year: 2008....
- Tick Midgut Thrombin Inhibitor as a Vaccine TargetSukanya Narasimhan; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Regulating I. scapularis and the Role of Entomopathogenic Fungi Thomas Daniels; Fiscal Year: 2008..scapularis in lab studies. Long- term health benefits might also accrue with the reduction in pesticide use those results from the availability of an effective biocontrol agent. [unreadable] [unreadable] [unreadable] [unreadable]..
- Perpetuation of Francisella tularensisSam R Telford; Fiscal Year: 2010..Taken together, these observations will provide a basis for understanding how the agent of tularemia is perpetuated on Martha's Vineyard, and why pneumonic human disease is prevalent there. ..
- A C.elegans high-throughput assay for the identification of new antifungal agentsEleftherios Mylonakis; Fiscal Year: 2010....
- ROLE OF TICK SALIVA IN LYME DISEASE AND VACCINE STRATEGYThomas Mather; Fiscal Year: 2006..We expect these studies to lead to new vaccination strategies that combine tick and bacterial elements for preventing Lyme disease, and possibly a broader range of tick-transmitted infections. ..
- Genesis & Control of Lyme Disease by Innate ImmunityLinda Bockenstedt; Fiscal Year: 2009..For the field of Lyme disease, defining the key molecules expressed by host-adapted spirochetes will move us one step closer toward understanding how this pathogen persists in an immunologically responsive host. ..
- GENE EXPRESSION BY TICK TRANSMITTED BORRELIA BURGDORFERIAravinda de Silva; Fiscal Year: 2002..This study will provide insight into tick-borne transmission of bacterial pathogens and lead to novel strategies for blocking transmission and preventing Lyme arthritis. ..
- BORRELIA BURGDORFERI GENE EXPRESSION IN TICK MIDGUT--ROLSukanya Narasimhan; Fiscal Year: 2002..The investigation will also be conducive to the development of a useful molecular tool/approach to analyze the gene expression patterns of other vector-borne pathogens in their vector environment. ..
- 3RD ANNUAL MUTANT MOUSE REGIONAL RESOURCE CENTER MEETINGStephen Barthold; Fiscal Year: 2003....
- Molecular analysis of tick-spirochete interactionsSukanya Narasimhan; Fiscal Year: 2003..This investigation will also serve to pave the way for elucidation of mechanisms underlying transmission of other tick-borne pathogens. ..
- Molcular detection of weaponized arenavirusesRemi Charrel; Fiscal Year: 2003..The ultimate goal is to propose a ready-to-use diagnostic kit for the detection and characterization of weaponized arenaviruses. ..
- BIOLOGY AND CONTROL OF LYME DISEASE BORRELIAAlan Barbour; Fiscal Year: 2004..burgdorferi, its transmission, and reservoir host immunize responses. The results may also have relevance for the control of other vector-bone zoonotic diseases and perhaps for development of novel methods for vaccine delivery. ..
- Comparison of US and European Babesia divergens IsolatesPatricia Holman; Fiscal Year: 2004..The molecular aspects may provide information that will be useful in future efforts to devise diagnostic tests. ..
- HELICOBACTER DIAGNOSTIC ASSAYS FOR LABORATORY MICEStephen Barthold; Fiscal Year: 2004..abstract_text> ..
- Tick gene expression- in the context of Lyme diseaseSukanya Narasimhan; Fiscal Year: 2005..This investigation may therefore serve to pave the way for elucidation of mechanisms underlying transmission of other tick-borne pathogens. ..
- C.elegans as a model system forC.neoformans pathogenesisEleftherios Mylonakis; Fiscal Year: 2007..Because C. neoformanshas similarities with other pathogenic yeasts, we expect that our findings will facilitate the study of fungus/host interaction in general. ..
- CD1-Mediated Immunity Of Lyme DiseaseLinda Bockenstedt; Fiscal Year: 2005..For the field of Lyme disease, defining the key molecules expressed by tick-borne spirochetes will move us one step closer toward understanding how this pathogen invades, disseminates and persists in the mammalian host. ..
- Anti-Complement Proteins of Ixodes ScapularisAravinda de Silva; Fiscal Year: 2007..Our industry partner in these studies is L2 diagnostics, which will assist with further development of tick anti-complement proteins as drugs and vaccines. ..
- Proximal determinants of risk for tularemia outbreaksSam Telford; Fiscal Year: 2004..tularensis in the environment; and, ultimately, a better understanding of F. tularensis-host interactions. ..
- Infection Dynamics of Ehrlichia chaffeensisAndrea Varela Stokes; Fiscal Year: 2006..Varela to develop into an outstanding medical parasitologist and add to the understanding of tick-borne disease and human health. ..
- Interactions between dengue 3 and human dendritic cellsAravinda de Silva; Fiscal Year: 2005..The results of these exploratory studies will be the basis of more in-depth future studies on the molecular pathogenesis of DEN3, subtype III viruses. ..
- LYME ARTHRITIS: A NEW EPIDEMIC DISEASEAllen C Steere; Fiscal Year: 2010..Furthermore, this work brings us closer to the long-term goal of direct comparisons of antigens in Lyme arthritis and rheumatoid arthritis synovia. ..
- Diagnosis and Pathogenesis of Early Lyme DiseaseAllen Steere; Fiscal Year: 2007..In addition, greater knowledge of spirochetal virulence and host factors associated with severe disease may allow the development of laboratory markers for patients who would benefit from more intensive treatment. ..
- MOLECULAR GENETIC MARKERS FOR TICK VECTORSHARRY HUTCHESON; Fiscal Year: 2002..I.) pacificus and I. (Ixodiopsis) woodi using 3 B. burgdorferi strains from the northeastern, southeastern, and western regions of the USA. ..