disease outbreaks

Summary

Summary: Sudden increase in the incidence of a disease. The concept includes epidemics and pandemics.

Top Publications

  1. ncbi Critically ill patients with 2009 influenza A(H1N1) infection in Canada
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre, JJ 399, 700 William Ave, Winnipeg, MB R3E 0Z3 Canada
    JAMA 302:1872-9. 2009
  2. ncbi Unifying the epidemiological and evolutionary dynamics of pathogens
    Bryan T Grenfell
    Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, UK
    Science 303:327-32. 2004
  3. pmc Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany
    David A Rasko
    University of Maryland School of Medicine, Institute for Genome Sciences and Department of Microbiology, Baltimore, USA
    N Engl J Med 365:709-17. 2011
  4. ncbi An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group
    M Ho
    National Health Research Institutes, Taipei, Taiwan
    N Engl J Med 341:929-35. 1999
  5. pmc Household transmission of 2009 pandemic influenza A (H1N1) virus in the United States
    Simon Cauchemez
    Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London
    N Engl J Med 361:2619-27. 2009
  6. ncbi Superspreading and the effect of individual variation on disease emergence
    J O Lloyd-Smith
    Department of Environmental Science, Policy and Management, 140 Mulford Hall, University of California, Berkeley, California 94720 3114, USA
    Nature 438:355-9. 2005
  7. ncbi Epidemic profile of Shiga-toxin-producing Escherichia coli O104:H4 outbreak in Germany
    Christina Frank
    Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany
    N Engl J Med 365:1771-80. 2011
  8. ncbi Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study
    Martina Bielaszewska
    Institute for Hygiene and the National Consulting Laboratory for Haemolytic Uraemic Syndrome, University of Munster, Munster, Germany
    Lancet Infect Dis 11:671-6. 2011
  9. ncbi Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States
    R S Lanciotti
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80522, USA
    Science 286:2333-7. 1999
  10. ncbi H1N1 2009 influenza virus infection during pregnancy in the USA
    Denise J Jamieson
    National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341 3717, USA
    Lancet 374:451-8. 2009

Detail Information

Publications359 found, 100 shown here

  1. ncbi Critically ill patients with 2009 influenza A(H1N1) infection in Canada
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre, JJ 399, 700 William Ave, Winnipeg, MB R3E 0Z3 Canada
    JAMA 302:1872-9. 2009
    ..Between March and July 2009, the largest number of confirmed cases of 2009 influenza A(H1N1) infection occurred in North America...
  2. ncbi Unifying the epidemiological and evolutionary dynamics of pathogens
    Bryan T Grenfell
    Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, UK
    Science 303:327-32. 2004
    ..A central pillar of this model is the Evolutionary Infectivity Profile, which captures the relationship between immune selection and pathogen transmission...
  3. pmc Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany
    David A Rasko
    University of Maryland School of Medicine, Institute for Genome Sciences and Department of Microbiology, Baltimore, USA
    N Engl J Med 365:709-17. 2011
    ..coli strains. Preliminary genetic characterization of the outbreak strain suggested that, unlike most of these strains, it should be classified within the enteroaggregative pathotype of E. coli...
  4. ncbi An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group
    M Ho
    National Health Research Institutes, Taipei, Taiwan
    N Engl J Med 341:929-35. 1999
    ..In 1998 an epidemic of enterovirus 71 infection caused hand-foot-and-mouth disease and herpangina in thousands of people in Taiwan, some of whom died...
  5. pmc Household transmission of 2009 pandemic influenza A (H1N1) virus in the United States
    Simon Cauchemez
    Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London
    N Engl J Med 361:2619-27. 2009
    ..Risk factors for transmission remain largely uncharacterized. We characterize the risk factors and describe the transmission of the virus within households...
  6. ncbi Superspreading and the effect of individual variation on disease emergence
    J O Lloyd-Smith
    Department of Environmental Science, Policy and Management, 140 Mulford Hall, University of California, Berkeley, California 94720 3114, USA
    Nature 438:355-9. 2005
    ..Our findings indicate that superspreading is a normal feature of disease spread, and to frame ongoing discussion we propose a rigorous definition for superspreading events and a method to predict their frequency...
  7. ncbi Epidemic profile of Shiga-toxin-producing Escherichia coli O104:H4 outbreak in Germany
    Christina Frank
    Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany
    N Engl J Med 365:1771-80. 2011
    ..The consumption of sprouts was identified as the most likely vehicle of infection...
  8. ncbi Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study
    Martina Bielaszewska
    Institute for Hygiene and the National Consulting Laboratory for Haemolytic Uraemic Syndrome, University of Munster, Munster, Germany
    Lancet Infect Dis 11:671-6. 2011
    ..We analysed virulence profiles and relevant phenotypes of outbreak isolates recovered in our laboratory...
  9. ncbi Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States
    R S Lanciotti
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80522, USA
    Science 286:2333-7. 1999
    ..This North American WN virus was most closely related to a WN virus isolated from a dead goose in Israel in 1998...
  10. ncbi H1N1 2009 influenza virus infection during pregnancy in the USA
    Denise J Jamieson
    National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341 3717, USA
    Lancet 374:451-8. 2009
    ..We summarised cases of infection with pandemic H1N1 virus in pregnant women identified in the USA during the first month of the present outbreak, and deaths associated with this virus during the first 2 months of the outbreak...
  11. ncbi Global patterns of influenza a virus in wild birds
    Bjorn Olsen
    Department of Infectious Diseases, Umea University, SE 90187 Umea, Sweden
    Science 312:384-8. 2006
    ....
  12. pmc Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans
    Rebecca J Garten
    WHO Collaborating Center for Influenza, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
    Science 325:197-201. 2009
    ..Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1)...
  13. ncbi Infection with chikungunya virus in Italy: an outbreak in a temperate region
    G Rezza
    Department of Infectious, Parasitic, and Immunomediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Lancet 370:1840-6. 2007
    ..Chikungunya virus (CHIKV), which is transmitted by Aedes spp mosquitoes, has recently caused several outbreaks on islands in the Indian Ocean and on the Indian subcontinent. We report on an outbreak in Italy...
  14. pmc The transmissibility and control of pandemic influenza A (H1N1) virus
    Yang Yang
    Center for Statistics and Quantitative Infectious Diseases, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA 98109, USA
    Science 326:729-33. 2009
    ..If a vaccine were available soon enough, vaccination of children, followed by adults, reaching 70% overall coverage, in addition to high-risk and essential workforce groups, could mitigate a severe epidemic...
  15. ncbi Modelling disease outbreaks in realistic urban social networks
    Stephen Eubank
    Basic and Applied Simulation Science Group, Los Alamos National Laboratory, MS M997, Los Alamos, New Mexico 87545, USA
    Nature 429:180-4. 2004
    ..Our results suggest that outbreaks can be contained by a strategy of targeted vaccination combined with early detection without resorting to mass vaccination of a population...
  16. ncbi An outbreak of hand, foot, and mouth disease associated with subgenotype C4 of human enterovirus 71 in Shandong, China
    Yong Zhang
    National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Xuanwu District, Beijing, PR China
    J Clin Virol 44:262-7. 2009
    ..An outbreak of hand, foot, and mouth disease (HFMD) included 1149 people in Linyi City, Shandong Province, China, in 2007: three children died...
  17. ncbi Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century
    Duane J Gubler
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Dept of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA
    Trends Microbiol 10:100-3. 2002
    ..Dengue fever/dengue hemorrhagic fever is now one of the most important public health problems in tropical developing countries and also has major economic and societal consequences...
  18. pmc The origin of the Haitian cholera outbreak strain
    Chen Shan Chin
    Pacific Biosciences, Menlo Park, CA, USA
    N Engl J Med 364:33-42. 2011
    ..Although cholera has been present in Latin America since 1991, it had not been epidemic in Haiti for at least 100 years. Recently, however, there has been a severe outbreak of cholera in Haiti...
  19. ncbi Climate warming and disease risks for terrestrial and marine biota
    C Drew Harvell
    Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY 14853, USA
    Science 296:2158-62. 2002
    ..To improve our ability to predict epidemics in wild populations, it will be necessary to separate the independent and interactive effects of multiple climate drivers on disease impact...
  20. ncbi The global emergence/resurgence of arboviral diseases as public health problems
    Duane J Gubler
    Department of Health and Human Services, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Fort Collins, CO 80522, USA
    Arch Med Res 33:330-42. 2002
    ....
  21. ncbi Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome
    Phillip I Tarr
    Division of Gastroenterology, Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, Campus Box 8208, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Lancet 365:1073-86. 2005
    ..The vascular injury leading to HUS is likely to be well under way by the time infected patients seek medical attention for diarrhoea. The best way to prevent HUS is to prevent primary infection with Shiga-toxin-producing bacteria...
  22. ncbi Whole-genome sequencing and social-network analysis of a tuberculosis outbreak
    Jennifer L Gardy
    British Columbia Centre for Disease Control, Vancouver, BC, Canada
    N Engl J Med 364:730-9. 2011
    ..Traditional contact tracing did not identify a source. We used whole-genome sequencing and social-network analysis in an effort to describe the outbreak dynamics at a higher resolution...
  23. ncbi A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality
    Vivian G Loo
    Department of Microbiology, McGill University Health Center, Montreal, Que, Canada
    N Engl J Med 353:2442-9. 2005
    ..In March 2003, several hospitals in Quebec, Canada, noted a marked increase in the incidence of Clostridium difficile-associated diarrhea...
  24. pmc The severity of pandemic H1N1 influenza in the United States, from April to July 2009: a Bayesian analysis
    Anne M Presanis
    Medical Research Council Biostatistics Unit, Cambridge, United Kingdom
    PLoS Med 6:e1000207. 2009
    ..We sought to estimate the probabilities that symptomatic infection would lead to hospitalization, ICU admission, and death by combining data from multiple sources...
  25. pmc Prospective genomic characterization of the German enterohemorrhagic Escherichia coli O104:H4 outbreak by rapid next generation sequencing technology
    Alexander Mellmann
    Institute of Hygiene, University Munster, Munster, Germany
    PLoS ONE 6:e22751. 2011
    ..In conclusion, rapid next-generation technologies facilitated prospective whole genome characterization in the early stages of an outbreak...
  26. ncbi Bats are natural reservoirs of SARS-like coronaviruses
    Wendong Li
    Institute of Zoology, Chinese Academy of Sciences CAS, Beijing, China
    Science 310:676-9. 2005
    ..The human and civet isolates of SARS-CoV nestle phylogenetically within the spectrum of SL-CoVs, indicating that the virus responsible for the SARS outbreak was a member of this coronavirus group...
  27. pmc Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome
    Ron A M Fouchier
    Department of Virology and National Influenza Center, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 101:1356-61. 2004
    ..Because H7N7 viruses have caused disease in mammals, including horses, seals, and humans, on several occasions in the past, they may be unusual in their zoonotic potential and, thus, form a pandemic threat to humans...
  28. pmc An emerging recombinant human enterovirus 71 responsible for the 2008 outbreak of hand foot and mouth disease in Fuyang city of China
    Yan Zhang
    Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
    Virol J 7:94. 2010
    ..In conclusion, an emerging recombinant HEV71 was responsible for the HFMD outbreak in Fuyang City of China, 2008...
  29. pmc West Nile fever--a reemerging mosquito-borne viral disease in Europe
    Z Hubalek
    Institute of Vertebrate Biology, Academy of Sciences, Brno, Czech Republic
    Emerg Infect Dis 5:643-50. 1999
    ....
  30. pmc Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998
    B A Brown
    Division of Viral Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Atlanta, Georgia 30333, USA
    J Virol 73:9969-75. 1999
    ..Its worldwide circulation and potential to cause severe disease underscore the need for additional surveillance and improved methods to identify EV71 in human disease...
  31. ncbi Tularemia as a biological weapon: medical and public health management
    D T Dennis
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, PO Box 2087, Fort Collins, CO 80522, USA
    JAMA 285:2763-73. 2001
    ..The Working Group on Civilian Biodefense has developed consensus-based recommendations for measures to be taken by medical and public health professionals if tularemia is used as a biological weapon against a civilian population...
  32. ncbi Closure of schools during an influenza pandemic
    Simon Cauchemez
    MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, St Mary s Campus, London, UK
    Lancet Infect Dis 9:473-81. 2009
    ..Implications for the mitigation of the swine-origin influenza A H1N1 pandemic are also discussed...
  33. ncbi Changing patterns of chikungunya virus: re-emergence of a zoonotic arbovirus
    Ann M Powers
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, 3150 Rampart Road, Fort Collins, CO 80521, USA
    J Gen Virol 88:2363-77. 2007
  34. ncbi An epidemic, toxin gene-variant strain of Clostridium difficile
    L Clifford McDonald
    Epidemiology and Laboratory Branch, Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 353:2433-41. 2005
    ..difficile with increased virulence, resistance, or both...
  35. pmc Pros and cons of estimating the reproduction number from early epidemic growth rate of influenza A (H1N1) 2009
    Hiroshi Nishiura
    PRESTO, Japan Science and Technology Agency, Honcho 4 1 8, Kawaguchi, Saitama, 332 0012, Japan
    Theor Biol Med Model 7:1. 2010
    ..The growth rate at the initial stage of the epidemic in Japan led to estimates for R in the range 2.0 to 2.6, capturing the intensity of the initial outbreak among school-age children in May 2009...
  36. pmc Systematic literature review of role of noroviruses in sporadic gastroenteritis
    Manish M Patel
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 14:1224-31. 2008
    ....
  37. ncbi Potential effect of population and climate changes on global distribution of dengue fever: an empirical model
    Simon Hales
    Department of Public Health, Wellington School of Medicine and Health Sciences, PO Box 7343, Mein Street, Wellington, New Zealand
    Lancet 360:830-4. 2002
    ..Our aim was to investigate the potential effects of global climate change on human health, and in particular, on the transmission of vector-borne diseases...
  38. pmc Simulation of an SEIR infectious disease model on the dynamic contact network of conference attendees
    Juliette Stehlé
    Centre de Physique Théorique de Marseille, CNRS UMR 6207, Marseille, France
    BMC Med 9:87. 2011
    ..In this study, we aimed to assess the role of data-driven dynamic contact patterns between individuals, and in particular of their temporal aspects, in shaping the spread of a simulated epidemic in the population...
  39. pmc Lineage 1 and 2 strains of encephalitic West Nile virus, central Europe
    Tamas Bakonyi
    University of Veterinary Medicine, Vienna, Austria
    Emerg Infect Dis 12:618-23. 2006
    ..The emergence of an exotic WNV strain in Hungary emphasizes the role of migrating birds in introducing new viruses to Europe...
  40. pmc Epidemic dynamics at the human-animal interface
    James O Lloyd-Smith
    Department of Ecology and Evolutionary Biology, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Science 326:1362-7. 2009
    ..Progress in understanding and combating zoonoses requires a new generation of models that addresses a broader set of pathogen life histories and integrates across host species and scientific disciplines...
  41. ncbi Nipah virus: a recently emergent deadly paramyxovirus
    K B Chua
    Department of Medical Microbiology, University of Malaya Medical Center, 50603 Kuala Lumpur, Malaysia
    Science 288:1432-5. 2000
    ..Like Hendra virus, Nipah virus is unusual among the paramyxoviruses in its ability to infect and cause potentially fatal disease in a number of host species, including humans...
  42. pmc Estimates of the prevalence of pandemic (H1N1) 2009, United States, April-July 2009
    Carrie Reed
    Influenza Division, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop A32, Atlanta, GA 30033, USA
    Emerg Infect Dis 15:2004-7. 2009
    ..Correcting for under-ascertainment using a multiplier model, we estimate that 1.8 million-5.7 million cases occurred, including 9,000-21,000 hospitalizations...
  43. ncbi Clinical features of the initial cases of 2009 pandemic influenza A (H1N1) virus infection in China
    Bin Cao
    Beijing Chao Yang Hospital, Beijing Institute of Respiratory Medicine, Capital Medical University, Beijing, China
    N Engl J Med 361:2507-17. 2009
    ..Persons in whom infection was confirmed were hospitalized and quarantined, and some of them were closely observed for the purpose of investigating the nature and duration of the disease...
  44. pmc Simulating school closure strategies to mitigate an influenza epidemic
    Bruce Y Lee
    University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Public Health Manag Pract 16:252-61. 2010
    ..The ongoing 2009 H1N1 influenza pandemic has provided an unparalleled opportunity to test interventions with the most up-to-date simulations...
  45. pmc The association between extreme precipitation and waterborne disease outbreaks in the United States, 1948-1994
    F C Curriero
    Department of Biostatistics, Johns Hopkins University, Baltimore, MD, USA
    Am J Public Health 91:1194-9. 2001
    OBJECTIVES: Rainfall and runoff have been implicated in site-specific waterborne disease outbreaks. Because upward trends in heavy precipitation in the United States are projected to increase with climate change, this study sought to ..
  46. pmc Modeling targeted layered containment of an influenza pandemic in the United States
    M Elizabeth Halloran
    Virginia Bioinformatics Institute, Virginia Polytechnical Institute and State University, Blacksburg, VA 24061, USA
    Proc Natl Acad Sci U S A 105:4639-44. 2008
    ....
  47. ncbi German outbreak of Escherichia coli O104:H4 associated with sprouts
    Udo Buchholz
    Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany
    N Engl J Med 365:1763-70. 2011
    ..A large outbreak of the hemolytic-uremic syndrome caused by Shiga-toxin-producing Escherichia coli O104:H4 occurred in Germany in May 2011. The source of infection was undetermined...
  48. pmc A rare genotype of Cryptococcus gattii caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada)
    S E Kidd
    Department of Medicine, University of Sydney, Sydney, NSW 2006, Australia
    Proc Natl Acad Sci U S A 101:17258-63. 2004
    ..The emergence of this usually tropical pathogen on Vancouver Island highlights the changing distribution of this genotype and emphasizes the importance of an ongoing collaborative effort to monitor the global epidemiology of this yeast...
  49. ncbi Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic
    Gavin J D Smith
    State Key Laboratory of Emerging Infectious Diseases and Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China
    Nature 459:1122-5. 2009
    ..Our results highlight the need for systematic surveillance of influenza in swine, and provide evidence that the mixing of new genetic elements in swine can result in the emergence of viruses with pandemic potential in humans...
  50. pmc Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness
    David M Morens
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 198:962-70. 2008
    ..Despite the availability of published data on 4 pandemics that have occurred over the past 120 years, there is little modern information on the causes of death associated with influenza pandemics...
  51. pmc A space-time permutation scan statistic for disease outbreak detection
    Martin Kulldorff
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, USA
    PLoS Med 2:e59. 2005
    The ability to detect disease outbreaks early is important in order to minimize morbidity and mortality through timely implementation of disease prevention and control measures...
  52. pmc Emergence and pandemic potential of swine-origin H1N1 influenza virus
    Gabriele Neumann
    Department of Pathobiological Sciences, University of Wisconsin Madison, Madison, Wisconsin 53711, USA
    Nature 459:931-9. 2009
    ....
  53. pmc Genome microevolution of chikungunya viruses causing the Indian Ocean outbreak
    Isabelle Schuffenecker
    Centre National de Référence des Arbovirus, Institut Pasteur, Lyon, France
    PLoS Med 3:e263. 2006
    ..Besides the arthralgic form, 123 patients with a confirmed chikungunya infection have developed severe clinical signs, i.e., neurological signs or fulminant hepatitis...
  54. pmc Two Chikungunya isolates from the outbreak of La Reunion (Indian Ocean) exhibit different patterns of infection in the mosquito, Aedes albopictus
    Marie Vazeille
    Département de Virologie Chikungunya program, Institut Pasteur, Paris, France
    PLoS ONE 2:e1168. 2007
    ..The implicated vector was Aedes albopictus. Here, we present the first study on the susceptibility of Ae. albopictus populations to sympatric CHIKV isolates from La Réunion Island and compare it to other virus/vector combinations...
  55. pmc Variation in virulence among clades of Escherichia coli O157:H7 associated with disease outbreaks
    Shannon D Manning
    Microbial Evolution Laboratory, National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 105:4868-73. 2008
    ..The ability to detect and rapidly genotype O157 strains belonging to such lineages is important and will have a significant impact on both disease diagnosis and treatment guidelines...
  56. pmc Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda
    Jonathan S Towner
    Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Pathog 4:e1000212. 2008
    ....
  57. ncbi Factors associated with death or hospitalization due to pandemic 2009 influenza A(H1N1) infection in California
    Janice K Louie
    California Department of Public Health, 850 Marina Bay Pkwy, Richmond, CA 94804, USA
    JAMA 302:1896-902. 2009
    ..Pandemic influenza A(H1N1) emerged rapidly in California in April 2009. Preliminary comparisons with seasonal influenza suggest that pandemic 2009 influenza A(H1N1) disproportionately affects younger ages and causes generally mild disease...
  58. pmc Epidemiology, genetics, and ecology of toxigenic Vibrio cholerae
    S M Faruque
    Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1000, Bangladesh
    Microbiol Mol Biol Rev 62:1301-14. 1998
    ..The ecosystem comprising V. cholerae, CTXPhi, the aquatic environment, and the mammalian host offers an understanding of the complex relationship between pathogenesis and the natural selection of a pathogen...
  59. ncbi Fruit bats as reservoirs of Ebola virus
    Eric M Leroy
    Centre International de Recherches Medicales de Franceville, BP 769 Franceville, Gabon
    Nature 438:575-6. 2005
    ..We find evidence of asymptomatic infection by Ebola virus in three species of fruit bat, indicating that these animals may be acting as a reservoir for this deadly virus...
  60. ncbi West Nile virus: an overview of its spread in Europe and the Mediterranean basin in contrast to its spread in the Americas
    H G Zeller
    Institut Pasteur, National Reference Center for Arboviruses, 21 Avenue Tony Garnier, 69365 Lyon Cedex 07, France
    Eur J Clin Microbiol Infect Dis 23:147-56. 2004
    ..Nevertheless, outbreaks of WN virus remain unpredictable. Further coordinated studies are needed for a better understanding of the ecology and the pathogenicity of the WN virus...
  61. ncbi Neuraminidase inhibitors for influenza
    Anne Moscona
    Department of Pediatrics, Weill Medical College of Cornell University, New York, NY 10021, USA
    N Engl J Med 353:1363-73. 2005
  62. pmc Estimated epidemiologic parameters and morbidity associated with pandemic H1N1 influenza
    Ashleigh R Tuite
    Research Institute of the Hospital for Sick Children, and the Dalla Lana School of Public Health, Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario
    CMAJ 182:131-6. 2010
    ..We sought to estimate epidemiologic parameters for pandemic H1N1 influenza using data from initial reports of laboratory-confirmed cases...
  63. pmc Emergence and pathogenicity of highly virulent Cryptococcus gattii genotypes in the northwest United States
    Edmond J Byrnes
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS Pathog 6:e1000850. 2010
    ..Our evidence documents emerging hypervirulent genotypes in the United States that may expand further and provides insight into the possible molecular and geographic origins of the outbreak...
  64. pmc Mortality from pandemic A/H1N1 2009 influenza in England: public health surveillance study
    Liam J Donaldson
    Department of Health, Richmond House, London SW1A 2NS
    BMJ 339:b5213. 2009
    ..To establish mortality from pandemic A/H1N1 2009 influenza up to 8 November 2009...
  65. pmc Association between climate variability and malaria epidemics in the East African highlands
    Guofa Zhou
    Department of Biological Sciences, State University of New York, Buffalo, NY 14260, USA
    Proc Natl Acad Sci U S A 101:2375-80. 2004
    ....
  66. ncbi Transmission of influenza A in human beings
    Gabrielle Brankston
    Infection Prevention and Control Unit, University Health Network, Toronto, Ontario, Canada
    Lancet Infect Dis 7:257-65. 2007
    ..Further research is required to better define conditions under which the influenza virus may transmit via the airborne route...
  67. pmc Epidemic hand, foot and mouth disease caused by human enterovirus 71, Singapore
    Kwai Peng Chan
    Virology Laboratory, Department of Pathology, Singapore General Hospital, Outram Road, Singapore
    Emerg Infect Dis 9:78-85. 2003
    ..A preparedness plan for severe HFMD outbreaks provided for the prompt, coordinated actions needed to control the epidemic...
  68. ncbi Chikungunya, an epidemic arbovirosis
    Gilles Pialoux
    Hopital Tenon, Service des Maladies Infectieuses et Tropicales, Paris, France
    Lancet Infect Dis 7:319-27. 2007
    ..Plausible explanations include increased tourism, chikungunya virus introduction into a naive population, and viral mutation...
  69. ncbi Optimizing influenza vaccine distribution
    Jan Medlock
    Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, New Haven, CT 06520 8034, USA
    Science 325:1705-8. 2009
    ..We also found that previous and new recommendations from the U.S. Centers for Disease Control and Prevention both for the novel swine-origin influenza and, particularly, for seasonal influenza, are suboptimal for all outcome measures...
  70. pmc Population genetics of Vibrio cholerae from Nepal in 2010: evidence on the origin of the Haitian outbreak
    Rene S Hendriksen
    National Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark
    MBio 2:e00157-11. 2011
    ....
  71. pmc Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011
    Yonatan H Grad
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 109:3065-70. 2012
    ..coli outbreak populations, or uneven distribution of diversity in the seed populations that led to each outbreak...
  72. ncbi Transmission of H7N7 avian influenza A virus to human beings during a large outbreak in commercial poultry farms in the Netherlands
    Marion Koopmans
    Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, Bilthoven, Netherlands
    Lancet 363:587-93. 2004
    ..Although the risk of transmission of these viruses to humans was initially thought to be low, an outbreak investigation was launched to assess the extent of transmission of influenza A virus subtype H7N7 from chickens to humans...
  73. pmc Genome sequence analyses of two isolates from the recent Escherichia coli outbreak in Germany reveal the emergence of a new pathotype: Entero-Aggregative-Haemorrhagic Escherichia coli (EAHEC)
    Elzbieta Brzuszkiewicz
    Göttingen Genomics Laboratory, Department of Genomic and Applied Microbiology, Institute of Microbiology and Genetics, Georg August University Gottingen, Grisebachstr 8, 37077, Gottingen, Germany
    Arch Microbiol 193:883-91. 2011
    ....
  74. pmc Reemergence of enterovirus 71 in 2008 in taiwan: dynamics of genetic and antigenic evolution from 1998 to 2008
    Sheng Wen Huang
    Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, One University Road, Tainan, 701, Taiwan
    J Clin Microbiol 47:3653-62. 2009
    ..Therefore, continuous surveillance of EV71 including the monitoring of genetic evolution and antigenic changes is recommended and may contribute to the development of a vaccine for EV71...
  75. pmc Phylogeography takes a relaxed random walk in continuous space and time
    Philippe Lemey
    Department of Microbiology and Immunology, Katholieke Universiteit Leuven, Leuven, Belgium
    Mol Biol Evol 27:1877-85. 2010
    ....
  76. ncbi Epochal evolution shapes the phylodynamics of interpandemic influenza A (H3N2) in humans
    Katia Koelle
    Department of Ecology and Evolutionary Biology, 2019 Kraus Natural Science Building, University of Michigan, 830 North University Avenue, Ann Arbor, MI 48109 1048, USA
    Science 314:1898-903. 2006
    ..It captures the observed boom-and-bust pattern of viral evolution, with periods of antigenic stasis during which genetic diversity grows, and with episodic contraction of this diversity during cluster transitions...
  77. pmc Early alterations of the receptor-binding properties of H1, H2, and H3 avian influenza virus hemagglutinins after their introduction into mammals
    M Matrosovich
    Department of Virology and Molecular Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, Russia
    J Virol 74:8502-12. 2000
    ....
  78. pmc The role of the airline transportation network in the prediction and predictability of global epidemics
    Vittoria Colizza
    School of Informatics and Center for Biocomplexity, Indiana University, Bloomington, IN 47401, USA
    Proc Natl Acad Sci U S A 103:2015-20. 2006
    ..These measures may be used for the analysis of containment policies and epidemic risk assessment...
  79. ncbi Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe
    Michel Warny
    Acambis Inc, Cambridge, MA, USA
    Lancet 366:1079-84. 2005
    ..We characterised the dominant strain of this epidemic to determine whether it produces higher amounts of toxins A and B than those produced by non-epidemic strains...
  80. ncbi The largest outbreak of hand; foot and mouth disease in Singapore in 2008: the role of enterovirus 71 and coxsackievirus A strains
    Yan Wu
    Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge 117597, Singapore
    Int J Infect Dis 14:e1076-81. 2010
    ..During 2008, Singapore experienced its largest ever outbreak of hand, foot and mouth disease (HFMD), resulting in 29686 cases, including four cases of encephalitis and one fatality...
  81. pmc Review of aerosol transmission of influenza A virus
    Raymond Tellier
    Division of Microbiology, Hospital for Sick Children, Toronto, Ontario, Canada
    Emerg Infect Dis 12:1657-62. 2006
    ....
  82. ncbi Rift Valley fever epidemic in Saudi Arabia: epidemiological, clinical, and laboratory characteristics
    Tariq A Madani
    Ministry of Health, Riyadh, Saudi
    Clin Infect Dis 37:1084-92. 2003
    ..Patients with leukopenia had significantly a lower mortality rate than did those with a normal or high leukocyte count (2.3% vs. 27.9%; odds ratio, 0.09; 95% confidence interval, 0.01-0.63)...
  83. pmc Foodborne illness acquired in the United States--unspecified agents
    Elaine Scallan
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 17:16-22. 2011
    ..8-61.2 million) episodes of domestically acquired foodborne illness were caused by unspecified agents, resulting in 71,878 hospitalizations (90% CrI 9,924-157,340) and 1,686 deaths (90% CrI 369-3,338)...
  84. ncbi Outbreak of 2009 pandemic influenza A (H1N1) at a New York City school
    Justin Lessler
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    N Engl J Med 361:2628-36. 2009
    ..In April 2009, an outbreak of novel swine-origin influenza A (2009 H1N1 influenza) occurred at a high school in Queens, New York. We describe the outbreak and characterize the clinical and epidemiologic aspects of this novel virus...
  85. pmc Global capacity for emerging infectious disease detection
    Emily H Chan
    Division of Health Sciences and Technology, HealthMap, Children s Hospital Informatics Program, Harvard Massachusetts Institute of Technology Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 107:21701-6. 2010
    ..119 per year, 95% CI (1.025; 1.221)] showed improvement in public communication. These findings provide quantitative historical assessment of timeliness in infectious disease detection and public reporting of outbreaks...
  86. pmc Seasonal transmission potential and activity peaks of the new influenza A(H1N1): a Monte Carlo likelihood analysis based on human mobility
    Duygu Balcan
    Center for Complex Networks and Systems Research, School of Informatics and Computing, Indiana University, Bloomington, IN, USA
    BMC Med 7:45. 2009
    ....
  87. ncbi An overview of the epidemiology of avian influenza
    Dennis J Alexander
    Virology Department, VLA Weybridge, Addlestone, Surrey, UK
    Vaccine 25:5637-44. 2007
    ....
  88. pmc Characterization of Dengue virus type 2: new insights on the 2010 Brazilian epidemic
    Camila Malta Romano
    Departamento de Moléstias Infecciosas e Parasitárias LIMHC, Instituto de Medicina Tropical de São Paulo e Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 5:e11811. 2010
    ..This is the first description of the 2010 outbreak in the State of São Paulo, Brazil, and should contribute to efforts to control and monitor the spread of DENVs in endemic areas...
  89. pmc Epidemiology of Escherichia coli O157:H7 outbreaks, United States, 1982-2002
    Josefa M Rangel
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 11:603-9. 2005
    ..3%) laboratory-related. The food vehicle for 75 (41%) foodborne outbreaks was ground beef, and for 38 (21%) outbreaks, produce...
  90. ncbi Discovery of swine as a host for the Reston ebolavirus
    Roger W Barrette
    Foreign Animal Disease Diagnostic Laboratory, National Veterinary Services Laboratories, Animal and Plant Health Inspection Services, United States Department of Agriculture, Plum Island Animal Disease Center, New York, NY 11944, USA
    Science 325:204-6. 2009
    ....
  91. pmc Transmission of human infection with Nipah virus
    Stephen P Luby
    International Centre for Diarrheal Diseases Research, Bangladesh, Dhaka, Bangladesh
    Clin Infect Dis 49:1743-8. 2009
    ..Efforts to prevent transmission should focus on decreasing bat access to date palm sap and reducing family members' and friends' exposure to infected patients' saliva...
  92. ncbi Household transmission of 2009 influenza A (H1N1) virus after a school-based outbreak in New York City, April-May 2009
    Anne Marie France
    Epidemic Intelligence Service, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 201:984-92. 2010
    ..Fifty percent of cases occurred within 3 days of onset of illness in the student. These factors have implications for mitigating the impact of pH1N1 transmission...
  93. ncbi Pandemic 2009 influenza A(H1N1) virus illness among pregnant women in the United States
    Alicia M Siston
    Epidemic Intelligence Service, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    JAMA 303:1517-25. 2010
    ..Early data on pandemic 2009 influenza A(H1N1) suggest pregnant women are at increased risk of hospitalization and death...
  94. ncbi Influenza: old and new threats
    Peter Palese
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Med 10:S82-7. 2004
    ....
  95. pmc Prediction of a Rift Valley fever outbreak
    Assaf Anyamba
    National Aeronautics and Space Administration Goddard Space Flight Center, Biospheric Sciences Branch, Code 614 4, Greenbelt, MD 20771, USA
    Proc Natl Acad Sci U S A 106:955-9. 2009
    ..To our knowledge, this is the first prospective prediction of a RVF outbreak...
  96. pmc Reassortment of pandemic H1N1/2009 influenza A virus in swine
    D Vijaykrishna
    State Key Laboratory of Emerging Infectious Diseases and Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China
    Science 328:1529. 2010
    ..Continued reassortment of H1N1/2009 with swine influenza viruses could produce variants with transmissibility and altered virulence for humans. Global systematic surveillance of influenza viruses in swine is warranted...
  97. pmc Estimation of the reproductive number and the serial interval in early phase of the 2009 influenza A/H1N1 pandemic in the USA
    Laura Forsberg White
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Influenza Other Respir Viruses 3:267-76. 2009
    ..Appropriate public health responses to this pandemic depend in part on early estimates of key epidemiological parameters of the virus in defined populations...
  98. pmc Rift Valley fever during rainy seasons, Madagascar, 2008 and 2009
    Soa Fy Andriamandimby
    Institut Pasteur, Antananarivo, Madagascar
    Emerg Infect Dis 16:963-70. 2010
    ..To better predict and respond to RVF outbreaks in Madagascar, further epidemiologic studies are needed, such as RVFV complete genome analysis, ruminant movement mapping, and surveillance implementation...
  99. ncbi Hemorrhagic fever viruses as biological weapons: medical and public health management
    Luciana Borio
    Johns Hopkins Center for Civilian Biodefense Strategies, Johns Hopkins Schools of Medicine and Public Health, 111 Market Pl, Suite 830, Baltimore, MD 21202, USA
    JAMA 287:2391-405. 2002
    ..To develop consensus-based recommendations for measures to be taken by medical and public health professionals if hemorrhagic fever viruses (HFVs) are used as biological weapons against a civilian population...
  100. ncbi Norovirus illness is a global problem: emergence and spread of norovirus GII.4 variants, 2001-2007
    J Joukje Siebenga
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    J Infect Dis 200:802-12. 2009
    ..4. We studied the global patterns of GII.4 epidemiology in relation to its genetic diversity...

Research Grants63

  1. Enhanced Membrane Systems for Supplying Quality Drinking Water
    Andrew Feiring; Fiscal Year: 2013
    ..Waterborne disease outbreaks continue to occur within the US and the etiological agents vary considerably...
  2. Fast accurate ultrasensitive in vitro assay to determine BoNT potency &stability
    ARMIN H REITMAIR; Fiscal Year: 2012
    ..thereby translating cutting-edge innovations in nanobiotechnology into benefits for the society at large by saving human lives, monitoring the population for bioterror attacks and disease outbreaks, and reducing healthcare costs.
  3. Development of a recombinant Nipah virus vaccine for wildlife
    MILOSZ ANDRZEJ FABER; Fiscal Year: 2010
    ..toward effective Nipah vaccines for wildlife and domestic animals that will be useful for control of future disease outbreaks and potential international translocation of the Nipah virus...
  4. Barcoded Magnetic Beads for Rapid Tests of MRSA and Respiratory Viral Panels
    WINSTON Z HO; Fiscal Year: 2010
    ..of H1N1 patients can mitigate many of the negative economic and social impacts associated with infectious disease outbreaks. Maxwell Sensors Inc...
  5. Bacterial effectors targeting the IKK/NF-kB pathway
    PHILIP ROSS HARDWIDGE; Fiscal Year: 2013
    ..We have made the important and unique discovery that the STEC strains associated with severe diarrheal disease outbreaks in humans express a pair of homologous effectors that differentially regulate host innate immunity by ..
  6. Connecticut Emerging Infections Program
    MATTHEW LEWIS CARTTER; Fiscal Year: 2011
    ..Shigelta spp., Vibrio spp., and Yersinia spp. to identify risk factors, investigate foodborne disease outbreaks, and define the magnitude of foodbome illness;3) Surveillance for Respiratory Diseases: population based ..
  7. Environmental Health Programs through the Environmental Health Specialists Networ
    Guthrie S Birkhead; Fiscal Year: 2013
    ..to identify and prevent environmental factors contributing to foodborne and/or waterborne illness and disease outbreaks. Its goals are to increase surveillance activities for food and waterborne disease, increase on-site field ..
  8. Ecological impacts of forest disturbance on La Crosse encephalitis virus dynamics
    MARIA RICHETTA CAMILLE HARRIS; Fiscal Year: 2010
    ..Changes to interior forest habitat may impact viral dynamics leading ultimately to human disease outbreaks. Forest canopy disturbance (FCD) due to logging is rapidly increasing worldwide, with unknown potential ..
  9. Clostridium perfringens Type B-D Virulence Plasmids
    Francisco A Uzal; Fiscal Year: 2013
    ..of subtyping assays for molecular epidemiologic or forensic investigations of natural or bioterrorism disease outbreaks involving type B-D isolates...
  10. EID - Effects of avian migration & anthropogenic change on the distribution & tra
    Thomas Smith; Fiscal Year: 2009
    Although human-induced habitat disturbances are known to be the primary drivers of numerous infectious disease outbreaks and emergence events, the impact of global anthropogenic change on the wildlife ecology of diseases remains under-..
  11. Multiplex Screening Panel for the Detection of Clostridium botulinum Toxin Genes
    Andrew C Whelen; Fiscal Year: 2013
    ..Genes; Staphylococcal Enterotoxin genes) in Food: Liquid MicroArray xTAG Technology Abstract Food borne disease outbreaks and food borne illnesses place a significant load on the health care system in the United States each year...
  12. Microbiota Outgrowth by Salmonella
    ANDREAS J BAUMLER; Fiscal Year: 2013
    ..from diarrheal disease associated with viruses, parasites or bacteria and the leading cause of food-borne disease outbreaks in the United States, producing between $0.5 billion to $2...
  13. Infectious Diseases/Basic Microbial Pathogenic Mechanisms
    Daniel E Goldberg; Fiscal Year: 2013
    ..It is rare that a week goes by without some troubling headline concerning new infectious disease outbreaks. Thus, far from gradual disappearance as a health concern, infectious diseases have emerged in the past ..
  14. The Impact of Flu and Flu Vaccine on NH Resident Morbitidity
    Vincent Mor; Fiscal Year: 2011
    ..Influenza is one of the leading causes of infectious disease outbreaks in NH and efforts to increase the rates of preventative vaccination of this population have had varying ..
  15. Compact ALEX-based Reader for Highly Multiplexed Single Biomolecule Detection
    Taiho Kim; Fiscal Year: 2010
    ..status, and initiation of treatment, while it concomitantly allows monitoring the public and environment for disease outbreaks, drug resistance trends, and potential bioterrorism attacks...
  16. Massively parallel sequencing of the diapause transcriptome in Aedes albopictus
    Christine Elsik; Fiscal Year: 2010
    ..mosquito from its native Asian range across the globe during the last 20 years and its recent involvement in disease outbreaks represents an outstanding public health concern...
  17. Separation of HIV Infected Prison Inmates: Perceptions and Clinical Outcomes
    David A Wohl; Fiscal Year: 2012
    ..Lastly, disease outbreaks (e.g., tuberculosis) can occur when immune- compromised inmates are co-housed...
  18. Characterization of novel genes encoded ty RNA and DNA viruses
    Ralph S Baric; Fiscal Year: 2013
    ..identify novel targets for therapeutic intervention, d) improve strategies for live attenuated or vectored virus vaccine design, and e) improve global responses to newly identified, epidemic disease outbreaks in human populations.
  19. An Intregated System for the Epidemiological Application of Earth Observation Tec
    Michael C Wimberly; Fiscal Year: 2011
    ..of satellite remote sensing data to generate environmental measurements that can provide early warning of disease outbreaks, (2) Analyze the predictive capabilities of these remote sensing products using retrospective datasets of ..
  20. Mechanism of streptococcus virulence regulation by bacterial peptide signals
    Muthiah Kumaraswami; Fiscal Year: 2013
    ..Given the recent rise in GAS invasive disease outbreaks, antibiotic resistance in GAS and lack of a human vaccine, the need to identify novel antimicrobial targets ..
  21. Models for improving surveillance of environmentally-mediated infectious diseases
    JUSTIN VICTOR REMAIS; Fiscal Year: 2013
    ..can be used to inform public health decision-making, such as where and when to focus surveillance for disease outbreaks. The proposed study will be the first to investigate how environmental information can be used to improve ..
  22. Adapting Natural Language Processing Tools for Biosurveillance
    Debbie A Travers; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Early detection of disease outbreaks can decrease patient morbidity and mortality and minimize the spread of diseases...
  23. Trivalent Arenaviral Vaccine Based on Virus-Like Particle Vectors (VLPVs)
    PETER M PUSHKO; Fiscal Year: 2011
    ..The successful trivalent vaccine can be used for the containment of disease outbreaks in non-endemic areas, as well as for vaccination of medical workers, military personnel, travelers, and ..
  24. Outbreak detection:combinatorial tests for small samples
    SCOTT D FERSON; Fiscal Year: 2010
    ..They should therefore be useful in monitoring disease outbreaks, or other non-random patterns of events of health concern, amid sparse data associated with institutional ..
  25. A Sindbis virus-based Vaccine Against RVFV Infection
    Ilya Frolov; Fiscal Year: 2006
    ..sub-Saharan Africa in 1997-98 and spread across the Red Sea to Saudi Arabia and Yemen, causing devastating disease outbreaks in sheep and cattle. The RVFV has potential for use in bioterrorism, and its projected effect on U.S...
  26. Data Extraction using EDR in Dental PBRN
    TITUS K SCHLEYER; Fiscal Year: 2012
    ..also be used for real-time epidemiologic surveys, development of disease registries and the monitoring of disease outbreaks. This project is a first step in making the increasing amount of electronic clinical data available for ..
  27. Envirnomental Health Specialist Network
    RICHARD NORMAN DANILA; Fiscal Year: 2010
    Foodborne disease outbreaks and case-control studies conducted through the federally funded Foodborne Diseases Active Surveillance Network (FoodNet) have demonstrated important food safety problems at commercial food establishments...
  28. ISO/IEC 17025:2005 ACCREDITATION FOR STATE FOOD TESTING LABORATORIES (U18) GRANT
    YAMIR ROSA; Fiscal Year: 2013
    ..of the FERN for the detection of microbiological and chemical contaminants in response to a food borne disease outbreaks or large-scale food emergencies would be an added benefit...
  29. Next generation sequencing of East African trypanosomes to expand the molecular e
    Adalgisa Caccone; Fiscal Year: 2012
    ..from closely related parasites found in animals, leading to confusion regarding the origins of human disease outbreaks. This project seeks to improve the tools available for understanding the epidemiology of this neglected ..
  30. Synthetic Information Systems for Better Informing Public Health Policymakers
    MADHAV VISHNU MARATHE; Fiscal Year: 2013
    ..and course-of-action analysis that policymakers can and will use to inform their response to infectious disease outbreaks. By synthetic information systems we mean software tools that synthesize diverse, seemingly incommensurate ..
  31. Geospatial Frontiers in Health and Social Environments
    Douglas Richardson; Fiscal Year: 2012
    ..From tracking disease outbreaks, to modeling the impacts of environmental risks on substance abuse, to understanding how neighborhood ..
  32. A Computational Framework for Assessing the Feasibility of Bio-emergency Response
    ARMIN ROBERT MIKLER; Fiscal Year: 2010
    ..establish specific time frames for different types of bioemergencies, either brought upon by natural disease outbreaks or bioterrorism...
  33. Spatially-explicit mathematical model of human monocytic ehrlichiosis
    HOLLY GAFF; Fiscal Year: 2010
    ..of this modeling effort will be new insights into the spatial and temporal distribution of human tick-borne disease outbreaks. Insights into the distribution patterns can be helpful for notification of medical professionals to be ..
  34. Envirnomental Health Specialist Network
    TRACEY L WEEKS; Fiscal Year: 2010
    ..The objectives of EHS-Net are to: 1) identify environmental antecedents to foodborne illness and disease outbreaks;2) translate findings into improved prevention efforts using a system-based approach;3) offer training ..
  35. Early warning indicators of tipping points in biological systems
    Jeff Gore; Fiscal Year: 2012
    ..Such ""tipping points"" include disease outbreaks, the collapse of populations, and cellular differentiation...
  36. Containing Bioterrorist and Emerging Infectious Diseases
    Ira M Longini; Fiscal Year: 2013
    ..of various interventions to aid the distribution and allocation of resources in response to infectious disease outbreaks. The specific aims are as follows: 1...
  37. Linking models and policy: Using active adaptive management for optimal control o
    Matthew Ferrari; Fiscal Year: 2013
    To control disease outbreaks, critical decisions are necessary in the face of uncertainty...
  38. Ethical Standards to Improve Local Response Capacity to Infectious Disease Events
    Holly A Taylor; Fiscal Year: 2013
    ..document for local health departments to use in planning for and executing their responses to infectious disease outbreaks. Our aims are to: 1) Describe and characterize perceptions of legal and ethical obligations relevant to ..
  39. FDA Vet-LRN Site Application
    Shuping Zhang; Fiscal Year: 2013
    ..Rapid detection and response to potential foodborne disease outbreaks is necessary to limit the number of people and animals affected...
  40. Genetic Determinants of Anaplasma Transmission
    SUSAN NOH; Fiscal Year: 2004
    ..by ticks are unknown, representing a significant gap in our knowledge relevant to prevention of disease outbreaks. I propose to study transmissible and non-transmissible strains of Anaplasma marginale as a model to ..
  41. Decision Making in Biosurveillance
    MICHAEL MATTHEW WAGNER; Fiscal Year: 2011
    ..These systems collect less diagnostically precise--but earlier--surveillance data in an effort to detect disease outbreaks as early as possible...
  42. WETLAND URBANIZATION GRADIENTS AND VECTOR BORNE DISEASES
    JOSEPH KIESECKER; Fiscal Year: 2002
    ..Our goal is understand key forms of anthropogenic: change that influence disease outbreaks and to develop predictive models for the emergence and dynamics of amphibian trematode parasites in ..
  43. HealthMap: Knowledge Management for Emerging Infectious Disease Intelligence
    John S Brownstein; Fiscal Year: 2012
    ..These data sources provide local and timely information about disease outbreaks and related events around the world, including areas relatively invisible to day-to-day global public health ..
  44. DNA Minor Groove-binding Drugs and Food-borne Pathogens
    MARK PERRELLA; Fiscal Year: 2009
    ..require less expertise to handle, and by contaminating food products, they have the potential to produce disease outbreaks in large groups of people and over broad geographic regions...
  45. Envirnomental Health Specialist Network
    ERIC ALLAN PIPPERT; Fiscal Year: 2010
    ..has three charges, they are;(1) to identify and define environmental antecedents of foodborne illness and disease outbreaks, with an eye toward sharing the information with other states (2) to test practical environmental public ..
  46. International Symposium on Viral Respiratory Disease Surveillance
    Gregory Gray; Fiscal Year: 2009
    ..1 According to some experts, "[t]he challenges to effective global surveillance and response to human disease outbreaks reflect deficiencies in (1) health infrastructure;(2) scientific methods and concepts of operations of ..
  47. Data Evaluation for Early Disease Outbreak Detection
    Kenneth Kleinman; Fiscal Year: 2007
    ..not enough is known about the relative merits of different data sources for early[unreadable] detection of disease outbreaks.[unreadable] In this project we will evaluate and compare the efficacy of different health services data ..
  48. RENOVATION OF FACILITIES FOR SWINE BREEDING
    Craig Beattie; Fiscal Year: 2003
    ..genetic resource to be housed in the proposed swine unit is greater than ever while the risk of infectious disease outbreaks is escalating. The Institution is using large animal models for human disease(s) at an increasing rate...
  49. MECHANISMS OF ARBOVIRUS ADAPTATION TO MOSQUITO VECTORS
    Scott Weaver; Fiscal Year: 2000
    ..regulate the transmission of many arboviruses by mosquito vectors, influencing their ability to cause disease outbreaks. Emergence of arboviral diseases can also depend on the ability of zoonotic viruses to utilize different ..
  50. Disease Surveillance in Real Time: Geotemporal Methods
    Kenneth Mandl; Fiscal Year: 2009
    ..by using readily available information in realtime, thereby increasing the power of these systems to detect disease outbreaks sooner...
  51. New York State Envirnomental Health Specialist Network
    Dale L Morse; Fiscal Year: 2010
    ..and USDA) will work to improve the timeliness, accuracy and completeness of reporting of food and waterborne disease outbreaks. In addition, New York State will assist in developing standard reporting tools and will participate in ..
  52. 2012 Rhode Island State Health Lab FDA/FERN Microbiology Cooperative Agreement
    Ewa King; Fiscal Year: 2013
    ..is a member of the FERN and as such, is committed to preparedness for detection and response to foodborne disease outbreaks. The laboratory seeks to maintain capability, augmented through participation in the first cycle of ..
  53. SaTScan: Spatial Scan Statistic Surveillance Software II
    Martin Kulldorff; Fiscal Year: 2013
    ..around the world for geographical disease cluster detection and evaluation, and for the early detection of disease outbreaks. With the software, it is possible to determine whether disease cases are randomly distributed over space ..
  54. Food Safety: Discovering Novel Causes of Foodborne Illn*
    John Besser; Fiscal Year: 2006
    ..All specimens, including those from diarrheal disease outbreaks of unknown etiology in Minnesota or other FoodNet sites during the study period, will be analyzed with the ..
  55. The BioSense Initiative to Improve Early Event Detection
    Scott Wetterhall; Fiscal Year: 2007
    ..application to work with the Centers for Disease Control and Prevention (CDC) to improve early detection of disease outbreaks of public health significance...
  56. Modeling Anthropogenic Effects in the Spread of Infectious Diseases
    Charles Perrings; Fiscal Year: 2013
    ..introduced, and (b) to evaluate the potential for incentive-based policy responses to disease threats and disease outbreaks. The research team has been built over a number of years through collaboration in three networks: an RCN - ..
  57. GIVEN BUILDING ANIMAL FACILITY UPGRADE
    Russell Tracy; Fiscal Year: 2004
    ..In particular, this is required for the elimination of ongoing murine viral disease outbreaks in the research rodent holding operations...
  58. Modeling Health System Infectious Disease Data
    Susan S Huang; Fiscal Year: 2010
    Early detection- of bioterrorism and infectious disease outbreaks caused by emerging pathogens is very important for public health, to allow prompt implementation of control measures...
  59. Syndromic Surveillance Data Exchange and Analysis
    Shaun Grannis; Fiscal Year: 2005
    ..of health care disaster, is the term coined for systems that use data that precede diagnosis to recognize disease outbreaks with sufficient specificity to warrant a public health response...
  60. Engineered alkaline phosphatases as biosensors
    Ichiro Matsumura; Fiscal Year: 2004
    ..detection methods would enable more effective responses to bio-terrorism and natural infectious disease outbreaks. Our goal is to engineer a reporter enzyme so that is inactive until it encounters a pathogen marker...
  61. WORLD REFERENCE CENTER FOR ARBOVIRUSES
    Robert Tesh; Fiscal Year: 2002
    ..latter activities include: (1) virus identification and characterization; (2) investigation and diagnosis of disease outbreaks; (3) preparation and distribution of certified virus stocks and reagents; (4) development of new animal ..
  62. Enhanced Foodborne Surveillance Application to Nursing
    MARY DERBY; Fiscal Year: 2007
    ..S. Although most food borne disease outbreaks (FBDOs) are related to naturally occurring events, they have also been produced by deliberate contamination...
  63. Detectability of Epidemics from Over-the-Counter Sales
    Garrick Wallstrom; Fiscal Year: 2006
    ..To measure the time when naturally occurring disease outbreaks are detected from sales of the best OTC healthcare product categories (as determined by product screening ..