disease outbreaks

Summary

Summary: Sudden increase in the incidence of a disease. The concept includes epidemics and pandemics.

Top Publications

  1. pmc Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany
    David A Rasko
    University of Maryland School of Medicine, Institute for Genome Sciences and Department of Microbiology, Baltimore, USA
    N Engl J Med 365:709-17. 2011
  2. doi Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study
    Martina Bielaszewska
    Institute for Hygiene and the National Consulting Laboratory for Haemolytic Uraemic Syndrome, University of Munster, Munster, Germany
    Lancet Infect Dis 11:671-6. 2011
  3. doi Critically ill patients with 2009 influenza A(H1N1) infection in Canada
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre, JJ 399, 700 William Ave, Winnipeg, MB R3E 0Z3 Canada
    JAMA 302:1872-9. 2009
  4. doi Epidemic profile of Shiga-toxin-producing Escherichia coli O104:H4 outbreak in Germany
    Christina Frank
    Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany
    N Engl J Med 365:1771-80. 2011
  5. pmc Household transmission of 2009 pandemic influenza A (H1N1) virus in the United States
    Simon Cauchemez
    Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London
    N Engl J Med 361:2619-27. 2009
  6. pmc Prospective genomic characterization of the German enterohemorrhagic Escherichia coli O104:H4 outbreak by rapid next generation sequencing technology
    Alexander Mellmann
    Institute of Hygiene, University Munster, Munster, Germany
    PLoS ONE 6:e22751. 2011
  7. ncbi Unifying the epidemiological and evolutionary dynamics of pathogens
    Bryan T Grenfell
    Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, UK
    Science 303:327-32. 2004
  8. doi German outbreak of Escherichia coli O104:H4 associated with sprouts
    Udo Buchholz
    Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany
    N Engl J Med 365:1763-70. 2011
  9. doi H1N1 2009 influenza virus infection during pregnancy in the USA
    Denise J Jamieson
    National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341 3717, USA
    Lancet 374:451-8. 2009
  10. pmc Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans
    Rebecca J Garten
    WHO Collaborating Center for Influenza, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
    Science 325:197-201. 2009

Detail Information

Publications337 found, 100 shown here

  1. pmc Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany
    David A Rasko
    University of Maryland School of Medicine, Institute for Genome Sciences and Department of Microbiology, Baltimore, USA
    N Engl J Med 365:709-17. 2011
    ..coli strains. Preliminary genetic characterization of the outbreak strain suggested that, unlike most of these strains, it should be classified within the enteroaggregative pathotype of E. coli...
  2. doi Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study
    Martina Bielaszewska
    Institute for Hygiene and the National Consulting Laboratory for Haemolytic Uraemic Syndrome, University of Munster, Munster, Germany
    Lancet Infect Dis 11:671-6. 2011
    ..We analysed virulence profiles and relevant phenotypes of outbreak isolates recovered in our laboratory...
  3. doi Critically ill patients with 2009 influenza A(H1N1) infection in Canada
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre, JJ 399, 700 William Ave, Winnipeg, MB R3E 0Z3 Canada
    JAMA 302:1872-9. 2009
    ..Between March and July 2009, the largest number of confirmed cases of 2009 influenza A(H1N1) infection occurred in North America...
  4. doi Epidemic profile of Shiga-toxin-producing Escherichia coli O104:H4 outbreak in Germany
    Christina Frank
    Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany
    N Engl J Med 365:1771-80. 2011
    ..The consumption of sprouts was identified as the most likely vehicle of infection...
  5. pmc Household transmission of 2009 pandemic influenza A (H1N1) virus in the United States
    Simon Cauchemez
    Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London
    N Engl J Med 361:2619-27. 2009
    ..Risk factors for transmission remain largely uncharacterized. We characterize the risk factors and describe the transmission of the virus within households...
  6. pmc Prospective genomic characterization of the German enterohemorrhagic Escherichia coli O104:H4 outbreak by rapid next generation sequencing technology
    Alexander Mellmann
    Institute of Hygiene, University Munster, Munster, Germany
    PLoS ONE 6:e22751. 2011
    ..In conclusion, rapid next-generation technologies facilitated prospective whole genome characterization in the early stages of an outbreak...
  7. ncbi Unifying the epidemiological and evolutionary dynamics of pathogens
    Bryan T Grenfell
    Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, UK
    Science 303:327-32. 2004
    ..A central pillar of this model is the Evolutionary Infectivity Profile, which captures the relationship between immune selection and pathogen transmission...
  8. doi German outbreak of Escherichia coli O104:H4 associated with sprouts
    Udo Buchholz
    Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany
    N Engl J Med 365:1763-70. 2011
    ..A large outbreak of the hemolytic-uremic syndrome caused by Shiga-toxin-producing Escherichia coli O104:H4 occurred in Germany in May 2011. The source of infection was undetermined...
  9. doi H1N1 2009 influenza virus infection during pregnancy in the USA
    Denise J Jamieson
    National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341 3717, USA
    Lancet 374:451-8. 2009
    ..We summarised cases of infection with pandemic H1N1 virus in pregnant women identified in the USA during the first month of the present outbreak, and deaths associated with this virus during the first 2 months of the outbreak...
  10. pmc Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans
    Rebecca J Garten
    WHO Collaborating Center for Influenza, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
    Science 325:197-201. 2009
    ..Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1)...
  11. ncbi Superspreading and the effect of individual variation on disease emergence
    J O Lloyd-Smith
    Department of Environmental Science, Policy and Management, 140 Mulford Hall, University of California, Berkeley, California 94720 3114, USA
    Nature 438:355-9. 2005
    ..Our findings indicate that superspreading is a normal feature of disease spread, and to frame ongoing discussion we propose a rigorous definition for superspreading events and a method to predict their frequency...
  12. pmc The origin of the Haitian cholera outbreak strain
    Chen Shan Chin
    Pacific Biosciences, Menlo Park, CA, USA
    N Engl J Med 364:33-42. 2011
    ..Although cholera has been present in Latin America since 1991, it had not been epidemic in Haiti for at least 100 years. Recently, however, there has been a severe outbreak of cholera in Haiti...
  13. ncbi An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group
    M Ho
    National Health Research Institutes, Taipei, Taiwan
    N Engl J Med 341:929-35. 1999
    ..In 1998 an epidemic of enterovirus 71 infection caused hand-foot-and-mouth disease and herpangina in thousands of people in Taiwan, some of whom died...
  14. pmc The transmissibility and control of pandemic influenza A (H1N1) virus
    Yang Yang
    Center for Statistics and Quantitative Infectious Diseases, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA 98109, USA
    Science 326:729-33. 2009
    ..If a vaccine were available soon enough, vaccination of children, followed by adults, reaching 70% overall coverage, in addition to high-risk and essential workforce groups, could mitigate a severe epidemic...
  15. ncbi Infection with chikungunya virus in Italy: an outbreak in a temperate region
    G Rezza
    Department of Infectious, Parasitic, and Immunomediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Lancet 370:1840-6. 2007
    ..Chikungunya virus (CHIKV), which is transmitted by Aedes spp mosquitoes, has recently caused several outbreaks on islands in the Indian Ocean and on the Indian subcontinent. We report on an outbreak in Italy...
  16. ncbi Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century
    Duane J Gubler
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Dept of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA
    Trends Microbiol 10:100-3. 2002
    ..Dengue fever/dengue hemorrhagic fever is now one of the most important public health problems in tropical developing countries and also has major economic and societal consequences...
  17. ncbi Fruit bats as reservoirs of Ebola virus
    Eric M Leroy
    Centre International de Recherches Medicales de Franceville, BP 769 Franceville, Gabon
    Nature 438:575-6. 2005
    ..We find evidence of asymptomatic infection by Ebola virus in three species of fruit bat, indicating that these animals may be acting as a reservoir for this deadly virus...
  18. doi Whole-genome sequencing and social-network analysis of a tuberculosis outbreak
    Jennifer L Gardy
    British Columbia Centre for Disease Control, Vancouver, BC, Canada
    N Engl J Med 364:730-9. 2011
    ..Traditional contact tracing did not identify a source. We used whole-genome sequencing and social-network analysis in an effort to describe the outbreak dynamics at a higher resolution...
  19. ncbi Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome
    Phillip I Tarr
    Division of Gastroenterology, Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, Campus Box 8208, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Lancet 365:1073-86. 2005
    ..The vascular injury leading to HUS is likely to be well under way by the time infected patients seek medical attention for diarrhoea. The best way to prevent HUS is to prevent primary infection with Shiga-toxin-producing bacteria...
  20. pmc The severity of pandemic H1N1 influenza in the United States, from April to July 2009: a Bayesian analysis
    Anne M Presanis
    Medical Research Council Biostatistics Unit, Cambridge, United Kingdom
    PLoS Med 6:e1000207. 2009
    ..We sought to estimate the probabilities that symptomatic infection would lead to hospitalization, ICU admission, and death by combining data from multiple sources...
  21. doi An outbreak of hand, foot, and mouth disease associated with subgenotype C4 of human enterovirus 71 in Shandong, China
    Yong Zhang
    National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Xuanwu District, Beijing, PR China
    J Clin Virol 44:262-7. 2009
    ..An outbreak of hand, foot, and mouth disease (HFMD) included 1149 people in Linyi City, Shandong Province, China, in 2007: three children died...
  22. ncbi A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality
    Vivian G Loo
    Department of Microbiology, McGill University Health Center, Montreal, Que, Canada
    N Engl J Med 353:2442-9. 2005
    ..In March 2003, several hospitals in Quebec, Canada, noted a marked increase in the incidence of Clostridium difficile-associated diarrhea...
  23. pmc Emergence and pandemic potential of swine-origin H1N1 influenza virus
    Gabriele Neumann
    Department of Pathobiological Sciences, University of Wisconsin Madison, Madison, Wisconsin 53711, USA
    Nature 459:931-9. 2009
    ....
  24. doi Closure of schools during an influenza pandemic
    Simon Cauchemez
    MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, St Mary s Campus, London, UK
    Lancet Infect Dis 9:473-81. 2009
    ..Implications for the mitigation of the swine-origin influenza A H1N1 pandemic are also discussed...
  25. pmc Pros and cons of estimating the reproduction number from early epidemic growth rate of influenza A (H1N1) 2009
    Hiroshi Nishiura
    PRESTO, Japan Science and Technology Agency, Honcho 4 1 8, Kawaguchi, Saitama, 332 0012, Japan
    Theor Biol Med Model 7:1. 2010
    ..The growth rate at the initial stage of the epidemic in Japan led to estimates for R in the range 2.0 to 2.6, capturing the intensity of the initial outbreak among school-age children in May 2009...
  26. pmc An emerging recombinant human enterovirus 71 responsible for the 2008 outbreak of hand foot and mouth disease in Fuyang city of China
    Yan Zhang
    Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
    Virol J 7:94. 2010
    ..In conclusion, an emerging recombinant HEV71 was responsible for the HFMD outbreak in Fuyang City of China, 2008...
  27. pmc Estimates of the prevalence of pandemic (H1N1) 2009, United States, April-July 2009
    Carrie Reed
    Influenza Division, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop A32, Atlanta, GA 30033, USA
    Emerg Infect Dis 15:2004-7. 2009
    ..Correcting for under-ascertainment using a multiplier model, we estimate that 1.8 million-5.7 million cases occurred, including 9,000-21,000 hospitalizations...
  28. ncbi Nipah virus: a recently emergent deadly paramyxovirus
    K B Chua
    Department of Medical Microbiology, University of Malaya Medical Center, 50603 Kuala Lumpur, Malaysia
    Science 288:1432-5. 2000
    ..Like Hendra virus, Nipah virus is unusual among the paramyxoviruses in its ability to infect and cause potentially fatal disease in a number of host species, including humans...
  29. doi Clinical features of the initial cases of 2009 pandemic influenza A (H1N1) virus infection in China
    Bin Cao
    Beijing Chao Yang Hospital, Beijing Institute of Respiratory Medicine, Capital Medical University, Beijing, China
    N Engl J Med 361:2507-17. 2009
    ..Persons in whom infection was confirmed were hospitalized and quarantined, and some of them were closely observed for the purpose of investigating the nature and duration of the disease...
  30. ncbi Bats are natural reservoirs of SARS-like coronaviruses
    Wendong Li
    Institute of Zoology, Chinese Academy of Sciences CAS, Beijing, China
    Science 310:676-9. 2005
    ..The human and civet isolates of SARS-CoV nestle phylogenetically within the spectrum of SL-CoVs, indicating that the virus responsible for the SARS outbreak was a member of this coronavirus group...
  31. pmc Simulating school closure strategies to mitigate an influenza epidemic
    Bruce Y Lee
    University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Public Health Manag Pract 16:252-61. 2010
    ..The ongoing 2009 H1N1 influenza pandemic has provided an unparalleled opportunity to test interventions with the most up-to-date simulations...
  32. doi Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic
    Gavin J D Smith
    State Key Laboratory of Emerging Infectious Diseases and Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China
    Nature 459:1122-5. 2009
    ..Our results highlight the need for systematic surveillance of influenza in swine, and provide evidence that the mixing of new genetic elements in swine can result in the emergence of viruses with pandemic potential in humans...
  33. pmc Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness
    David M Morens
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 198:962-70. 2008
    ..Despite the availability of published data on 4 pandemics that have occurred over the past 120 years, there is little modern information on the causes of death associated with influenza pandemics...
  34. doi Factors associated with death or hospitalization due to pandemic 2009 influenza A(H1N1) infection in California
    Janice K Louie
    California Department of Public Health, 850 Marina Bay Pkwy, Richmond, CA 94804, USA
    JAMA 302:1896-902. 2009
    ..Pandemic influenza A(H1N1) emerged rapidly in California in April 2009. Preliminary comparisons with seasonal influenza suggest that pandemic 2009 influenza A(H1N1) disproportionately affects younger ages and causes generally mild disease...
  35. pmc Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda
    Jonathan S Towner
    Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Pathog 4:e1000212. 2008
    ....
  36. pmc Variation in virulence among clades of Escherichia coli O157:H7 associated with disease outbreaks
    Shannon D Manning
    Microbial Evolution Laboratory, National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 105:4868-73. 2008
    ..The ability to detect and rapidly genotype O157 strains belonging to such lineages is important and will have a significant impact on both disease diagnosis and treatment guidelines...
  37. ncbi Neuraminidase inhibitors for influenza
    Anne Moscona
    Department of Pediatrics, Weill Medical College of Cornell University, New York, NY 10021, USA
    N Engl J Med 353:1363-73. 2005
  38. doi Epidemic dynamics at the human-animal interface
    James O Lloyd-Smith
    Department of Ecology and Evolutionary Biology, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Science 326:1362-7. 2009
    ..Progress in understanding and combating zoonoses requires a new generation of models that addresses a broader set of pathogen life histories and integrates across host species and scientific disciplines...
  39. pmc Simulation of an SEIR infectious disease model on the dynamic contact network of conference attendees
    Juliette Stehlé
    Centre de Physique Théorique de Marseille, CNRS UMR 6207, Marseille, France
    BMC Med 9:87. 2011
    ..In this study, we aimed to assess the role of data-driven dynamic contact patterns between individuals, and in particular of their temporal aspects, in shaping the spread of a simulated epidemic in the population...
  40. pmc The role of the airline transportation network in the prediction and predictability of global epidemics
    Vittoria Colizza
    School of Informatics and Center for Biocomplexity, Indiana University, Bloomington, IN 47401, USA
    Proc Natl Acad Sci U S A 103:2015-20. 2006
    ..These measures may be used for the analysis of containment policies and epidemic risk assessment...
  41. pmc Emergence and pathogenicity of highly virulent Cryptococcus gattii genotypes in the northwest United States
    Edmond J Byrnes
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS Pathog 6:e1000850. 2010
    ..Our evidence documents emerging hypervirulent genotypes in the United States that may expand further and provides insight into the possible molecular and geographic origins of the outbreak...
  42. pmc Estimated epidemiologic parameters and morbidity associated with pandemic H1N1 influenza
    Ashleigh R Tuite
    Research Institute of the Hospital for Sick Children, and the Dalla Lana School of Public Health, Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario
    CMAJ 182:131-6. 2010
    ..We sought to estimate epidemiologic parameters for pandemic H1N1 influenza using data from initial reports of laboratory-confirmed cases...
  43. pmc Mortality from pandemic A/H1N1 2009 influenza in England: public health surveillance study
    Liam J Donaldson
    Department of Health, Richmond House, London SW1A 2NS
    BMJ 339:b5213. 2009
    ..To establish mortality from pandemic A/H1N1 2009 influenza up to 8 November 2009...
  44. pmc Epidemiology of Escherichia coli O157:H7 outbreaks, United States, 1982-2002
    Josefa M Rangel
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 11:603-9. 2005
    ..3%) laboratory-related. The food vehicle for 75 (41%) foodborne outbreaks was ground beef, and for 38 (21%) outbreaks, produce...
  45. doi Optimizing influenza vaccine distribution
    Jan Medlock
    Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, New Haven, CT 06520 8034, USA
    Science 325:1705-8. 2009
    ..We also found that previous and new recommendations from the U.S. Centers for Disease Control and Prevention both for the novel swine-origin influenza and, particularly, for seasonal influenza, are suboptimal for all outcome measures...
  46. ncbi Epochal evolution shapes the phylodynamics of interpandemic influenza A (H3N2) in humans
    Katia Koelle
    Department of Ecology and Evolutionary Biology, 2019 Kraus Natural Science Building, University of Michigan, 830 North University Avenue, Ann Arbor, MI 48109 1048, USA
    Science 314:1898-903. 2006
    ..It captures the observed boom-and-bust pattern of viral evolution, with periods of antigenic stasis during which genetic diversity grows, and with episodic contraction of this diversity during cluster transitions...
  47. pmc Early alterations of the receptor-binding properties of H1, H2, and H3 avian influenza virus hemagglutinins after their introduction into mammals
    M Matrosovich
    Department of Virology and Molecular Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, Russia
    J Virol 74:8502-12. 2000
    ....
  48. doi Outbreak of 2009 pandemic influenza A (H1N1) at a New York City school
    Justin Lessler
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    N Engl J Med 361:2628-36. 2009
    ..In April 2009, an outbreak of novel swine-origin influenza A (2009 H1N1 influenza) occurred at a high school in Queens, New York. We describe the outbreak and characterize the clinical and epidemiologic aspects of this novel virus...
  49. pmc Systematic literature review of role of noroviruses in sporadic gastroenteritis
    Manish M Patel
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 14:1224-31. 2008
    ....
  50. pmc Global capacity for emerging infectious disease detection
    Emily H Chan
    Division of Health Sciences and Technology, HealthMap, Children s Hospital Informatics Program, Harvard Massachusetts Institute of Technology Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 107:21701-6. 2010
    ..119 per year, 95% CI (1.025; 1.221)] showed improvement in public communication. These findings provide quantitative historical assessment of timeliness in infectious disease detection and public reporting of outbreaks...
  51. pmc Seasonal transmission potential and activity peaks of the new influenza A(H1N1): a Monte Carlo likelihood analysis based on human mobility
    Duygu Balcan
    Center for Complex Networks and Systems Research, School of Informatics and Computing, Indiana University, Bloomington, IN, USA
    BMC Med 7:45. 2009
    ....
  52. ncbi Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States
    R S Lanciotti
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80522, USA
    Science 286:2333-7. 1999
    ..This North American WN virus was most closely related to a WN virus isolated from a dead goose in Israel in 1998...
  53. doi Discovery of swine as a host for the Reston ebolavirus
    Roger W Barrette
    Foreign Animal Disease Diagnostic Laboratory, National Veterinary Services Laboratories, Animal and Plant Health Inspection Services, United States Department of Agriculture, Plum Island Animal Disease Center, New York, NY 11944, USA
    Science 325:204-6. 2009
    ....
  54. pmc Transmission of human infection with Nipah virus
    Stephen P Luby
    International Centre for Diarrheal Diseases Research, Bangladesh, Dhaka, Bangladesh
    Clin Infect Dis 49:1743-8. 2009
    ..Efforts to prevent transmission should focus on decreasing bat access to date palm sap and reducing family members' and friends' exposure to infected patients' saliva...
  55. pmc Population genetics of Vibrio cholerae from Nepal in 2010: evidence on the origin of the Haitian outbreak
    Rene S Hendriksen
    National Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark
    MBio 2:e00157-11. 2011
    ....
  56. doi Household transmission of 2009 influenza A (H1N1) virus after a school-based outbreak in New York City, April-May 2009
    Anne Marie France
    Epidemic Intelligence Service, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 201:984-92. 2010
    ..Fifty percent of cases occurred within 3 days of onset of illness in the student. These factors have implications for mitigating the impact of pH1N1 transmission...
  57. ncbi Global patterns of influenza a virus in wild birds
    Bjorn Olsen
    Department of Infectious Diseases, Umea University, SE 90187 Umea, Sweden
    Science 312:384-8. 2006
    ....
  58. doi Pandemic 2009 influenza A(H1N1) virus illness among pregnant women in the United States
    Alicia M Siston
    Epidemic Intelligence Service, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    JAMA 303:1517-25. 2010
    ..Early data on pandemic 2009 influenza A(H1N1) suggest pregnant women are at increased risk of hospitalization and death...
  59. ncbi Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe
    Michel Warny
    Acambis Inc, Cambridge, MA, USA
    Lancet 366:1079-84. 2005
    ..We characterised the dominant strain of this epidemic to determine whether it produces higher amounts of toxins A and B than those produced by non-epidemic strains...
  60. pmc Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998
    B A Brown
    Division of Viral Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Atlanta, Georgia 30333, USA
    J Virol 73:9969-75. 1999
    ..Its worldwide circulation and potential to cause severe disease underscore the need for additional surveillance and improved methods to identify EV71 in human disease...
  61. ncbi Tularemia as a biological weapon: medical and public health management
    D T Dennis
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, PO Box 2087, Fort Collins, CO 80522, USA
    JAMA 285:2763-73. 2001
    ..The Working Group on Civilian Biodefense has developed consensus-based recommendations for measures to be taken by medical and public health professionals if tularemia is used as a biological weapon against a civilian population...
  62. pmc Prediction of a Rift Valley fever outbreak
    Assaf Anyamba
    National Aeronautics and Space Administration Goddard Space Flight Center, Biospheric Sciences Branch, Code 614 4, Greenbelt, MD 20771, USA
    Proc Natl Acad Sci U S A 106:955-9. 2009
    ..To our knowledge, this is the first prospective prediction of a RVF outbreak...
  63. ncbi Influenza: old and new threats
    Peter Palese
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Med 10:S82-7. 2004
    ....
  64. pmc Reassortment of pandemic H1N1/2009 influenza A virus in swine
    D Vijaykrishna
    State Key Laboratory of Emerging Infectious Diseases and Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China
    Science 328:1529. 2010
    ..Continued reassortment of H1N1/2009 with swine influenza viruses could produce variants with transmissibility and altered virulence for humans. Global systematic surveillance of influenza viruses in swine is warranted...
  65. pmc Estimation of the reproductive number and the serial interval in early phase of the 2009 influenza A/H1N1 pandemic in the USA
    Laura Forsberg White
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Influenza Other Respir Viruses 3:267-76. 2009
    ..Appropriate public health responses to this pandemic depend in part on early estimates of key epidemiological parameters of the virus in defined populations...
  66. ncbi The global emergence/resurgence of arboviral diseases as public health problems
    Duane J Gubler
    Department of Health and Human Services, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Fort Collins, CO 80522, USA
    Arch Med Res 33:330-42. 2002
    ....
  67. ncbi An overview of the epidemiology of avian influenza
    Dennis J Alexander
    Virology Department, VLA Weybridge, Addlestone, Surrey, UK
    Vaccine 25:5637-44. 2007
    ....
  68. pmc A rare genotype of Cryptococcus gattii caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada)
    S E Kidd
    Department of Medicine, University of Sydney, Sydney, NSW 2006, Australia
    Proc Natl Acad Sci U S A 101:17258-63. 2004
    ..The emergence of this usually tropical pathogen on Vancouver Island highlights the changing distribution of this genotype and emphasizes the importance of an ongoing collaborative effort to monitor the global epidemiology of this yeast...
  69. pmc Rift Valley fever during rainy seasons, Madagascar, 2008 and 2009
    Soa Fy Andriamandimby
    Institut Pasteur, Antananarivo, Madagascar
    Emerg Infect Dis 16:963-70. 2010
    ..To better predict and respond to RVF outbreaks in Madagascar, further epidemiologic studies are needed, such as RVFV complete genome analysis, ruminant movement mapping, and surveillance implementation...
  70. ncbi Hemorrhagic fever viruses as biological weapons: medical and public health management
    Luciana Borio
    Johns Hopkins Center for Civilian Biodefense Strategies, Johns Hopkins Schools of Medicine and Public Health, 111 Market Pl, Suite 830, Baltimore, MD 21202, USA
    JAMA 287:2391-405. 2002
    ..To develop consensus-based recommendations for measures to be taken by medical and public health professionals if hemorrhagic fever viruses (HFVs) are used as biological weapons against a civilian population...
  71. doi Norovirus illness is a global problem: emergence and spread of norovirus GII.4 variants, 2001-2007
    J Joukje Siebenga
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    J Infect Dis 200:802-12. 2009
    ..4. We studied the global patterns of GII.4 epidemiology in relation to its genetic diversity...
  72. pmc Forecast and control of epidemics in a globalized world
    L Hufnagel
    Max Planck Institut für Strömungsforschung, Bunsenstrasse 10, 37073 Gottingen, Germany
    Proc Natl Acad Sci U S A 101:15124-9. 2004
    ..The performance of different control strategies is analyzed, and our simulations show that a quick and focused reaction is essential to inhibiting the global spread of epidemics...
  73. ncbi Neurological manifestations of enterovirus 71 infection in children during an outbreak of hand, foot, and mouth disease in Western Australia
    P McMinn
    Department of Microbiology, Princess Margaret Hospital for Children, Perth, WA, Australia
    Clin Infect Dis 32:236-42. 2001
    ..This finding is in contrast to reports of previous EV71 epidemics, in which virus-induced damage to gray matter was the most frequent cause of neurological disease...
  74. pmc Pandemic potential of a strain of influenza A (H1N1): early findings
    Christophe Fraser
    MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, Faculty of Medicine, Norfolk Place, London W2 1PG, UK
    Science 324:1557-61. 2009
    ..Transmissibility is therefore substantially higher than that of seasonal flu, and comparable with lower estimates of R0 obtained from previous influenza pandemics...
  75. ncbi Multiple Ebola virus transmission events and rapid decline of central African wildlife
    Eric M Leroy
    Institut de Recherche pour le Developpement, UR034, Centre International de Recherches Medicales de Franceville, BP 769 Franceville, Gabon
    Science 303:387-90. 2004
    ..Surveillance of animal mortality may help to predict and prevent human Ebola outbreaks...
  76. pmc Genetic analysis of viruses associated with emergence of Rift Valley fever in Saudi Arabia and Yemen, 2000-01
    Trevor Shoemaker
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 8:1415-20. 2002
    ..These results are consistent with the recent introduction of RVFV into the Arabian Peninsula from East Africa...
  77. ncbi Chikungunya, an epidemic arbovirosis
    Gilles Pialoux
    Hopital Tenon, Service des Maladies Infectieuses et Tropicales, Paris, France
    Lancet Infect Dis 7:319-27. 2007
    ..Plausible explanations include increased tourism, chikungunya virus introduction into a naive population, and viral mutation...
  78. pmc Student behavior during a school closure caused by pandemic influenza A/H1N1
    Joel C Miller
    Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 5:e10425. 2010
    ..The effectiveness of closing schools to reduce transmission depends largely on student/family behavior during the closure. We sought to improve our understanding of these behaviors...
  79. doi Vaccination against pandemic influenza A/H1N1v in England: a real-time economic evaluation
    Marc Baguelin
    Centre for Infections, Health Protection Agency, United Kingdom
    Vaccine 28:2370-84. 2010
    ..In countries where the epidemic is not so far advanced vaccination of children may be cost-effective. Similar, detailed, real-time modelling and economic studies could help to clarify the situation...
  80. ncbi Synchrony, waves, and spatial hierarchies in the spread of influenza
    Cecile Viboud
    Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA
    Science 312:447-51. 2006
    ..A simple epidemiological model, based on the gravity formulation, captures the observed increase of influenza spatial synchrony with transmissibility; high transmission allows influenza to spread rapidly beyond local spatial constraints...
  81. ncbi Network theory and SARS: predicting outbreak diversity
    Lauren Ancel Meyers
    Section of Integrative Biology and Institute for Cellular and Molecular Biology, University of Texas at Austin, 1 University Station C0930, Austin, TX 78712, USA
    J Theor Biol 232:71-81. 2005
    ..We offer quantitative insight into the heterogeneity of SARS outbreaks worldwide, and illustrate the utility of this approach for assessing public health strategies...
  82. ncbi Rift Valley fever epidemic in Saudi Arabia: epidemiological, clinical, and laboratory characteristics
    Tariq A Madani
    Ministry of Health, Riyadh, Saudi
    Clin Infect Dis 37:1084-92. 2003
    ..Patients with leukopenia had significantly a lower mortality rate than did those with a normal or high leukocyte count (2.3% vs. 27.9%; odds ratio, 0.09; 95% confidence interval, 0.01-0.63)...
  83. doi Severity of 2009 pandemic influenza A (H1N1) virus infection in pregnant women
    Andreea A Creanga
    Epidemic Intelligence Service Program, Office of Workforce and Career Development, National Center for Chronic Disease Prevention and Health Promotion, Atlanta, GA 30341 3717, USA
    Obstet Gynecol 115:717-26. 2010
    ..To examine 2009 H1N1 influenza illness severity and the effect of antiviral treatment on the severity of illness among pregnant women...
  84. pmc Modelling mitigation strategies for pandemic (H1N1) 2009
    Marija Zivkovic Gojovic
    Toronto Health Economics and Technology Assessment Collaborative, University of Toronto, Research Institute of the Hospital for Sick Children, Toronto, ON
    CMAJ 181:673-80. 2009
    ..Simulation models can be used to project the effectiveness of mitigation strategies, but the choice of the best scenario may change depending on model assumptions and uncertainties...
  85. pmc Optimizing infectious disease interventions during an emerging epidemic
    Jacco Wallinga
    Centre for Infectious Disease Control, National Institute for Public Health and the Environment, 3720 BA Bilthoven, Netherlands
    Proc Natl Acad Sci U S A 107:923-8. 2010
    ..highlights the continuous threat to public health posed by a steady stream of new and unexpected infectious disease outbreaks in animals and humans...
  86. doi Evolution of new variants of Vibrio cholerae O1
    Ashrafus Safa
    Department of Biology and Chemistry and MERIT, City University of Hong Kong, 83, Tat Chee Avenue, Kowloon Tong, Kowloon, Hong Kong SAR
    Trends Microbiol 18:46-54. 2010
    ..Here, we describe recent advances in our understanding of the epidemiology and evolution of the atypical El Tor strains...
  87. pmc Epidemic hand, foot and mouth disease caused by human enterovirus 71, Singapore
    Kwai Peng Chan
    Virology Laboratory, Department of Pathology, Singapore General Hospital, Outram Road, Singapore
    Emerg Infect Dis 9:78-85. 2003
    ..A preparedness plan for severe HFMD outbreaks provided for the prompt, coordinated actions needed to control the epidemic...
  88. pmc Understanding the link between malaria risk and climate
    Krijn P Paaijmans
    Center for Infectious Disease Dynamics, Department of Entomology, Chemical Ecology Laboratory, Pennsylvania State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 106:13844-9. 2009
    ..Such effects of short-term temperature fluctuations have not previously been considered but are central to understanding current malaria transmission and the consequences of climate change...
  89. ncbi Modelling disease outbreaks in realistic urban social networks
    Stephen Eubank
    Basic and Applied Simulation Science Group, Los Alamos National Laboratory, MS M997, Los Alamos, New Mexico 87545, USA
    Nature 429:180-4. 2004
    ..Our results suggest that outbreaks can be contained by a strategy of targeted vaccination combined with early detection without resorting to mass vaccination of a population...
  90. pmc Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome
    Ron A M Fouchier
    Department of Virology and National Influenza Center, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 101:1356-61. 2004
    ..Because H7N7 viruses have caused disease in mammals, including horses, seals, and humans, on several occasions in the past, they may be unusual in their zoonotic potential and, thus, form a pandemic threat to humans...
  91. ncbi Spatial clustering of malaria and associated risk factors during an epidemic in a highland area of western Kenya
    Simon Brooker
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 9:757-66. 2004
    ..Conditional multiple logistic regression analysis showed that the risk of malaria was higher in children who were underweight, who lived at lower altitudes, and who lived in households where drugs were not kept at home...
  92. pmc The pathology of influenza virus infections
    Jeffery K Taubenberger
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Annu Rev Pathol 3:499-522. 2008
    ....
  93. pmc Genome sequence analyses of two isolates from the recent Escherichia coli outbreak in Germany reveal the emergence of a new pathotype: Entero-Aggregative-Haemorrhagic Escherichia coli (EAHEC)
    Elzbieta Brzuszkiewicz
    Göttingen Genomics Laboratory, Department of Genomic and Applied Microbiology, Institute of Microbiology and Genetics, Georg August University Gottingen, Grisebachstr 8, 37077, Gottingen, Germany
    Arch Microbiol 193:883-91. 2011
    ....
  94. pmc How generation intervals shape the relationship between growth rates and reproductive numbers
    J Wallinga
    Department of Infectious Diseases Epidemiology, National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Proc Biol Sci 274:599-604. 2007
    ..Furthermore, we show that by taking the generation interval distribution equal to the observed distribution, it is possible to obtain an empirical estimate of the reproductive number...
  95. ncbi Outbreak of chikungunya on Reunion Island: early clinical and laboratory features in 157 adult patients
    Gianandrea Borgherini
    Service de Pneumologie et Maladies Infectieuses, Groupe Hospitalier Sud Reunion, Saint Pierre, La Reunion, France
    Clin Infect Dis 44:1401-7. 2007
    ..Chikungunya is a reemerging disease. In 2005-2006, a severe outbreak occurred on Reunion Island in the southwestern part of the Indian Ocean. Other islands in this area were affected during the same period...
  96. doi Multilocus variable-number tandem repeat analysis of Vibrio cholerae O1 El Tor strains harbouring classical toxin B
    Seon Young Choi
    International Vaccine Institute, Seoul, Republic of Korea
    J Med Microbiol 59:763-9. 2010
    ....
  97. pmc Relatedness of Vibrio cholerae O1/O139 isolates from patients and their household contacts, determined by multilocus variable-number tandem-repeat analysis
    Emily A Kendall
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    J Bacteriol 192:4367-76. 2010
    ..Our results demonstrate that genetically related V. cholerae strains cluster in local outbreaks but also suggest that multiple distinct strains of V. cholerae O1 may circulate simultaneously within a household...
  98. pmc Risk factors for severe Rift Valley fever infection in Kenya, 2007
    Amwayi S Anyangu
    Ministry of Public Health and Sanitation, Nairobi, Kenya
    Am J Trop Med Hyg 83:14-21. 2010
    ..67, 95% CI = 1.07-12.64, PAR% = 47%). Exposures related to animal contact were associated with acute RVF infection, whereas exposures to mosquitoes were not independent risk factors...
  99. pmc Phylodynamic reconstruction reveals norovirus GII.4 epidemic expansions and their molecular determinants
    J Joukje Siebenga
    National Institute for Public Health and the Environment, RIVM, Bilthoven, The Netherlands
    PLoS Pathog 6:e1000884. 2010
    ..The observed pattern of continually emerging novel variants of GII.4, causing elevated numbers of infections, is therefore a cause for concern...
  100. pmc Person-to-person transmission of Nipah virus in a Bangladeshi community
    Emily S Gurley
    Program on Infectious Diseases and Vaccine Sciences, ICDDR, B, Dhaka, Bangladesh
    Emerg Infect Dis 13:1031-7. 2007
    ..Capacity for person-to-person transmission increases the potential for wider spread of this highly lethal pathogen and highlights the need for infection control strategies for resource-poor settings...

Research Grants78

  1. EID - Effects of avian migration & anthropogenic change on the distribution & tra
    Thomas Smith; Fiscal Year: 2009
    Although human-induced habitat disturbances are known to be the primary drivers of numerous infectious disease outbreaks and emergence events, the impact of global anthropogenic change on the wildlife ecology of diseases remains under-..
  2. EID - Effects of avian migration & anthropogenic change on the distribution & tra
    Thomas Smith; Fiscal Year: 2007
    Although human-induced habitat disturbances are known to be the primary drivers of numerous infectious disease outbreaks and emergence events, the impact of global anthropogenic change on the wildlife ecology of diseases remains under-..
  3. A Sindbis virus-based Vaccine Against RVFV Infection
    Ilya Frolov; Fiscal Year: 2006
    ..sub-Saharan Africa in 1997-98 and spread across the Red Sea to Saudi Arabia and Yemen, causing devastating disease outbreaks in sheep and cattle. The RVFV has potential for use in bioterrorism, and its projected effect on U.S...
  4. Clostridium perfringens Type B-D Virulence Plasmids
    Francisco A Uzal; Fiscal Year: 2010
    ..of subtyping assays for molecular epidemiologic or forensic investigations of natural or bioterrorism disease outbreaks involving type B-D isolates...
  5. Clostridium perfringens Type B-D Virulence Plasmids
    BRUCE MC CLANE; Fiscal Year: 2009
    ..of subtyping assays for molecular epidemiologic or forensic investigations of natural or bioterrorism disease outbreaks involving type B-D isolates...
  6. Genetic Determinants of Anaplasma Transmission
    SUSAN NOH; Fiscal Year: 2004
    ..by ticks are unknown, representing a significant gap in our knowledge relevant to prevention of disease outbreaks. I propose to study transmissible and non-transmissible strains of Anaplasma marginale as a model to ..
  7. WETLAND URBANIZATION GRADIENTS AND VECTOR BORNE DISEASES
    JOSEPH KIESECKER; Fiscal Year: 2002
    ..Our goal is understand key forms of anthropogenic: change that influence disease outbreaks and to develop predictive models for the emergence and dynamics of amphibian trematode parasites in ..
  8. Spatially-explicit mathematical model of human monocytic ehrlichiosis
    HOLLY GAFF; Fiscal Year: 2007
    ..of this modeling effort will be new insights into the spatial and temporal distribution of human tick-borne disease outbreaks. Insights into the distribution patterns can be helpful for notification of medical professionals to be ..
  9. An Intregated System for the Epidemiological Application of Earth Observation Tec
    Michael C Wimberly; Fiscal Year: 2010
    ..of satellite remote sensing data to generate environmental measurements that can provide early warning of disease outbreaks, (2) Analyze the predictive capabilities of these remote sensing products using retrospective datasets of ..
  10. An Intregated System for the Epidemiological Application of Earth Observation Tec
    Michael C Wimberly; Fiscal Year: 2010
    ..of satellite remote sensing data to generate environmental measurements that can provide early warning of disease outbreaks, (2) Analyze the predictive capabilities of these remote sensing products using retrospective datasets of ..
  11. WORLD REFERENCE CENTER FOR ARBOVIRUSES
    Robert Tesh; Fiscal Year: 2001
    ..Specific aims are: (1) virus identification and characterization, (2) investigation and diagnosis of disease outbreaks, (3) preparation and distribution of certified virus strains and reagents, (4) development of new techniques ..
  12. DNA Minor Groove-binding Drugs and Food-borne Pathogens
    MARK PERRELLA; Fiscal Year: 2007
    ..require less expertise to handle, and by contaminating food products, they have the potential to produce disease outbreaks in large groups of people and over broad geographic regions...
  13. Modeling Health System Infectious Disease Data
    Richard Platt; Fiscal Year: 2007
    Early detection- of bioterrorism and infectious disease outbreaks caused by emerging pathogens is very important for public health, to allow prompt implementation of control measures...
  14. RNA DEPENDENT RNA POLYMERASE MECHANISM
    Craig Cameron; Fiscal Year: 2007
    ..Positive-strand RNA viruses cause a variety of diseases in humans. Strategies to control disease outbreaks caused by this category of viruses are needed...
  15. Data Evaluation for Early Disease Outbreak Detection
    Kenneth Kleinman; Fiscal Year: 2007
    Timely implementation of appropriate disease control measures is facilitated by earlier detection of disease outbreaks whether due to bioterrorism or naturally occurring pathogens...
  16. Connecticut Emerging Infections Program
    James Hadler; Fiscal Year: 2007
    ..Shigelta spp., Vibrio spp., and Yersinia spp. to identify risk factors, investigate foodborne disease outbreaks, and define the magnitude of foodbome illness; 3) Surveillance for Respiratory Diseases: population based ..
  17. RENOVATION OF FACILITIES FOR SWINE BREEDING
    Craig Beattie; Fiscal Year: 2003
    ..genetic resource to be housed in the proposed swine unit is greater than ever while the risk of infectious disease outbreaks is escalating. The Institution is using large animal models for human disease(s) at an increasing rate...
  18. Envirnomental Health Specialist Network
    Richard Danila; Fiscal Year: 2005
    Description (provided by Applicant): Foodborne disease outbreaks and case-control studies conducted through the federally funded Foodborne Diseases Active Surveillance Network (FoodNet) have demonstrated important food safety problems at ..
  19. Envirnomental Health Specialist Network
    Richard Danila; Fiscal Year: 2007
    Foodborne disease outbreaks and case-control studies conducted through the federally funded Foodborne Diseases Active Surveillance Network (FoodNet) have demonstrated important food safety problems at commercial food establishments...
  20. Envirnomental Health Specialist Network
    RICHARD NORMAN DANILA; Fiscal Year: 2010
    Foodborne disease outbreaks and case-control studies conducted through the federally funded Foodborne Diseases Active Surveillance Network (FoodNet) have demonstrated important food safety problems at commercial food establishments...
  21. The BioSense Initiative to Improve Early Event Detection
    Scott Wetterhall; Fiscal Year: 2005
    ..application to work with the Centers for Disease Control and Prevention (CDC) to improve early detection of disease outbreaks of public health significance...