maternal age

Summary

Summary: The age of the mother in PREGNANCY.

Top Publications

  1. ncbi Advanced maternal age. Part I: obstetric complications
    Ihab M Usta
    Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon
    Am J Perinatol 25:521-34. 2008
  2. pmc Maternal age and fetal loss: population based register linkage study
    A M Nybo Andersen
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, DK 2300 Copenhagen S, Denmark
    BMJ 320:1708-12. 2000
  3. pmc Twenty-year trends in the prevalence of Down syndrome and other trisomies in Europe: impact of maternal age and prenatal screening
    Maria Loane
    Institute of Nursing Research, University of Ulster, Jordanstown, UK
    Eur J Hum Genet 21:27-33. 2013
  4. ncbi Effect of maternal age on mitochondrial DNA copy number, ATP content and IVF outcome of bovine oocytes
    Hisataka Iwata
    Tokyo University of Agriculture, Funako 1737, Atugi City 243 0034, Japan
    Reprod Fertil Dev 23:424-32. 2011
  5. ncbi Advanced maternal age--how old is too old?
    Linda J Heffner
    Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, USA
    N Engl J Med 351:1927-9. 2004
  6. ncbi Advanced maternal age and the risk of cesarean birth: a systematic review
    Hamideh Bayrampour
    Faculty of Nursing, University of Manitoba, Winnipeg, Manitoba, Canada
    Birth 37:219-26. 2010
  7. ncbi Advanced maternal age and adverse perinatal outcome: a review of the evidence
    Mary Carolan
    Department of Nursing and Midwifery, University of Limerick, Ireland
    Midwifery 27:793-801. 2011
  8. ncbi Impact of labor induction, gestational age, and maternal age on cesarean delivery rates
    Linda J Heffner
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Obstet Gynecol 102:287-93. 2003
  9. ncbi Demographic and medical consequences of the postponement of parenthood
    L Schmidt
    Section of Social Medicine, Department of Public Health, University of Copenhagen, Denmark
    Hum Reprod Update 18:29-43. 2012
  10. ncbi The perinatal effects of delayed childbearing
    K S Joseph
    Perinatal Epidemiology Research Unit, Departments of Obstetrics and Gynaecology and Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada
    Obstet Gynecol 105:1410-8. 2005

Detail Information

Publications385 found, 100 shown here

  1. ncbi Advanced maternal age. Part I: obstetric complications
    Ihab M Usta
    Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon
    Am J Perinatol 25:521-34. 2008
    More women are postponing pregnancy into the fourth and fifth decades of life for a variety of reasons. Advanced maternal age, traditionally defined as age more than 35 years, has been associated with increased obstetric morbidity and ..
  2. pmc Maternal age and fetal loss: population based register linkage study
    A M Nybo Andersen
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, DK 2300 Copenhagen S, Denmark
    BMJ 320:1708-12. 2000
    To estimate the association between maternal age and fetal death (spontaneous abortion, ectopic pregnancy, stillbirth), taking into account a woman's reproductive history.
  3. pmc Twenty-year trends in the prevalence of Down syndrome and other trisomies in Europe: impact of maternal age and prenatal screening
    Maria Loane
    Institute of Nursing Research, University of Ulster, Jordanstown, UK
    Eur J Hum Genet 21:27-33. 2013
    ..differences in total and live birth prevalence of trisomies 21, 18 and 13 with regard to increasing maternal age and prenatal diagnosis in Europe. Twenty-one population-based EUROCAT registries covering 6...
  4. ncbi Effect of maternal age on mitochondrial DNA copy number, ATP content and IVF outcome of bovine oocytes
    Hisataka Iwata
    Tokyo University of Agriculture, Funako 1737, Atugi City 243 0034, Japan
    Reprod Fertil Dev 23:424-32. 2011
    The primary aim of the present study was to examine the effect of maternal age (in months) on mitochondrial DNA copy number (Mt number), ATP content and IVF outcome of bovine oocytes...
  5. ncbi Advanced maternal age--how old is too old?
    Linda J Heffner
    Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, USA
    N Engl J Med 351:1927-9. 2004
  6. ncbi Advanced maternal age and the risk of cesarean birth: a systematic review
    Hamideh Bayrampour
    Faculty of Nursing, University of Manitoba, Winnipeg, Manitoba, Canada
    Birth 37:219-26. 2010
    The increasing pregnancy rate at advanced maternal age is contemporaneous with the increasing rate of cesarean birth. Several studies have found that advanced maternal age is a risk factor for cesarean birth...
  7. ncbi Advanced maternal age and adverse perinatal outcome: a review of the evidence
    Mary Carolan
    Department of Nursing and Midwifery, University of Limerick, Ireland
    Midwifery 27:793-801. 2011
    To examine the evidence in relation to advanced maternal age (35-39 years), physiological risk and adverse perinatal outcome (stillbirth, low birth weight, preterm birth) in high-income countries.
  8. ncbi Impact of labor induction, gestational age, and maternal age on cesarean delivery rates
    Linda J Heffner
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Obstet Gynecol 102:287-93. 2003
    To quantify the impact of labor induction and maternal age on cesarean delivery rates in nulliparous and multiparous women between 36 and 42 weeks' gestation.
  9. ncbi Demographic and medical consequences of the postponement of parenthood
    L Schmidt
    Section of Social Medicine, Department of Public Health, University of Copenhagen, Denmark
    Hum Reprod Update 18:29-43. 2012
    ..Increasing public awareness of the impact of advanced female and male age on the reproductive outcome is essential for people to make well-informed decisions on when to start family formation...
  10. ncbi The perinatal effects of delayed childbearing
    K S Joseph
    Perinatal Epidemiology Research Unit, Departments of Obstetrics and Gynaecology and Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada
    Obstet Gynecol 105:1410-8. 2005
    ....
  11. ncbi Impact of maternal age on obstetric outcome
    Jane Cleary-Goldman
    Columbia University Medical Center, New York, New York, USA
    Obstet Gynecol 105:983-90. 2005
    To estimate the effect of maternal age on obstetric outcomes.
  12. pmc Advanced maternal age and adverse pregnancy outcome: evidence from a large contemporary cohort
    Louise C Kenny
    Department of Obstetrics and Gynaecology, The Anu Research Centre, University College Cork, Cork University Maternity Hospital, Cork, Ireland
    PLoS ONE 8:e56583. 2013
    Recent decades have witnessed an increase in mean maternal age at childbirth in most high-resourced countries. Advanced maternal age has been associated with several adverse maternal and perinatal outcomes...
  13. pmc Multiple meiotic errors caused by predivision of chromatids in women of advanced maternal age undergoing in vitro fertilisation
    Alan H Handyside
    London Bridge Fertility, Gynaecology and Genetics Centre, London, UK
    Eur J Hum Genet 20:742-7. 2012
    ..live births following both natural conception and in vitro fertilisation (IVF) and increases exponentially with maternal age in the decade preceding the menopause...
  14. pmc Chromosome cohesion decreases in human eggs with advanced maternal age
    Francesca E Duncan
    Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Aging Cell 11:1121-4. 2012
    Aneuploidy in human eggs increases with maternal age and can result in infertility, miscarriages, and birth defects...
  15. ncbi Advancing paternal age and risk of autism: new evidence from a population-based study and a meta-analysis of epidemiological studies
    C M Hultman
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Mol Psychiatry 16:1203-12. 2011
    ..26-3.88: P=0.006) more likely to have autism than offspring of men aged ≤29 years, after controlling for maternal age and documented risk factors for autism...
  16. ncbi Advanced maternal age and adverse perinatal outcome
    Bo Jacobsson
    Perinatal Centre, Department of Obstetrics and Gynecology, Sahlgrenska University Hospital Ostra, S 416 85 Goteborg, Sweden
    Obstet Gynecol 104:727-33. 2004
    The aim of this study was to investigate the influence of maternal age on perinatal and obstetric outcome in women aged 40-44 years and those 45 years or older and to estimate whether adverse outcome was related to intercurrent illness ..
  17. ncbi Caesarean section is associated with an increased risk of childhood-onset type 1 diabetes mellitus: a meta-analysis of observational studies
    C R Cardwell
    Department of Epidemiology and Public Health, School of Medicine and Dentistry, Queen s University Belfast, Grosvenor Road, Belfast, BT12 6BJ, UK
    Diabetologia 51:726-35. 2008
    ....
  18. pmc Implications of advancing paternal age: does it affect offspring school performance?
    Anna C Svensson
    Division of Public Health Epidemiology, Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 6:e24771. 2011
    ..After adjustment for year of graduation, maternal age and parental education, country of birth and parental mental health service use, offspring of fathers aged 50 ..
  19. ncbi The cytogenetics of polar bodies: insights into female meiosis and the diagnosis of aneuploidy
    Elpida Fragouli
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK
    Mol Hum Reprod 17:286-95. 2011
    ..Most aneuploidies originate during female meiosis and become increasingly common with advancing maternal age. To shed further light on the nature of aneuploidy in human oocytes, we utilized comparative genomic ..
  20. pmc Birth weight, maternal age, and education: new observations from Connecticut and Virginia
    A Shmueli
    The Joseph H. and Belle R. Braun Hebrew University, Hadassah School of Public Health and Community Medicine, Jerusalem, Israel
    Yale J Biol Med 72:245-58. 1999
    ..remains controversy about the mechanism(s) for this effect, as well as the interactions between these factors, maternal age, and race...
  21. ncbi Maternal age, ethnicity and gestational diabetes mellitus
    Mary Carolan
    School of Nursing and Midwifery, St Alban s Campus, Victoria University, PO Box 14228, Melbourne 8001, Australia
    Midwifery 28:778-83. 2012
    ..Factors linked to increasing incidence include older maternal age and non-Caucasian ethnicity...
  22. ncbi Polar body analysis by array comparative genomic hybridization accurately predicts aneuploidies of maternal meiotic origin in cleavage stage embryos of women of advanced maternal age
    Dimitra Christopikou
    Department of Embryogenesis, Centre for Human Reproduction, 15123 Athens, Greece
    Hum Reprod 28:1426-34. 2013
    ..array comparative genomic hybridization (array CGH) analysis of the first polar body (PB1) and second polar body (PB2) in predicting aneuploidies of maternal meiotic origin in the cleavage stage embryos of women of advanced maternal age?
  23. ncbi DNA microarray reveals that high proportions of human blastocysts from women of advanced maternal age are aneuploid and mosaic
    Jianqiao Liu
    Key Laboratory of Major Obstetrics Diseases of Guangdong Province, Guangzhou Medical College, Guangdong, China
    Biol Reprod 87:148. 2012
    ..These results indicate that high proportions of human blastocysts produced in vitro from women of advanced maternal age are aneuploid and mosaic. Errors can occur in any of the 23 pairs of chromosomes in human blastocysts...
  24. ncbi Association between maternal age and birth defects of unknown etiology: United States, 1997-2007
    Simerpal K Gill
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Birth Defects Res A Clin Mol Teratol 94:1010-8. 2012
    ..Both younger and older maternal age may pose increased risks for certain birth defects...
  25. ncbi Etiology and prevention of stillbirth
    Ruth C Fretts
    Harvard Vanguard Medical Associates, Wellesley, MA 02481, USA
    Am J Obstet Gynecol 193:1923-35. 2005
    ..This is a systematic review of the literature on the causes of stillbirth and clinical opinion regarding strategies for its prevention...
  26. pmc Racial differences in gene-specific DNA methylation levels are present at birth
    Ronald M Adkins
    University of Tennessee Health Science Center, Memphis, TN 48103, USA
    Birth Defects Res A Clin Mol Teratol 91:728-36. 2011
    ..The origin of these differences is inadequately understood, and this is a question of specific relevance to childhood and adult cancer...
  27. ncbi Defective deacetylation of histone 4 K12 in human oocytes is associated with advanced maternal age and chromosome misalignment
    I M van den Berg
    Department of Obstetrics and Gynaecology, Subdivision of Reproductive Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    Hum Reprod 26:1181-90. 2011
    ..meiosis are associated with low fertility in humans and the incidence of these errors increases with advancing maternal age. Studies of mitosis and meiosis suggest that defective remodeling of chromatin plays a causative role in ..
  28. ncbi A prospective observational study of domestic violence during pregnancy
    Nicole P Yost
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Obstet Gynecol 106:61-5. 2005
    ..To assess whether women reporting domestic violence are at increased risk for adverse pregnancy outcomes...
  29. ncbi Young maternal age and preterm birth
    Antônio A M da Silva
    Department of Public Health, University of Maranhão, and Department of Paediatrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    Paediatr Perinat Epidemiol 17:332-9. 2003
    The association between young maternal age and preterm birth (PTB) remains controversial...
  30. ncbi Fear of childbirth: predictors and temporal changes among nulliparous women in the Danish National Birth Cohort
    M Laursen
    Department of Obstetrics, Rigshospitalet, University Hospital of Copenhagen, Copenhagen Ø, Denmark
    BJOG 115:354-60. 2008
    ..To describe the association between fear of childbirth and social, demographic and psychological factors in a cohort of 30 480 healthy nulliparous women with uncomplicated singleton pregnancies...
  31. ncbi Increased second trimester maternal glucose levels are related to extremely large-for-gestational-age infants in women with type 1 diabetes
    Anneloes Kerssen
    Department of Perinatology and Gynaecology, University Medical Centre Utrecht, KE 04 123 1, P O Box 85090, 3508 AB Utrecht, The Netherlands
    Diabetes Care 30:1069-74. 2007
    ..We used the continuous glucose monitoring system (CGMS) to assess the relationship between 24-h diurnal glucose profiles in all three trimesters of pregnancy and infant birth weight...
  32. ncbi Maternal age and prevalence of isolated congenital heart defects in an urban area of the United States
    Assia Miller
    Division of Birth Defects and Developmental Disabilities, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Med Genet A 155:2137-45. 2011
    Although maternal age has been associated with a number of birth defects in several reports, the literature on the association of maternal age with isolated congenital heart defect (CHD) phenotypes has been limited...
  33. ncbi An analysis of the interrelationship between maternal age, body mass index and racial origin in the development of gestational diabetes mellitus
    M Makgoba
    Academic Department of Obstetrics and Gynaecology, Imperial College Faculty of Medicine, Chelsea and Westminster Hospital, London, UK
    BJOG 119:276-82. 2012
    To examine the individual association between advancing maternal age, body mass index (BMI) and racial origin with the development of gestational diabetes mellitus (GDM) and the interaction between these factors.
  34. ncbi Pregnancy outcomes for nulliparous women of advanced maternal age in South Australia, 1998-2008
    Isobel Ludford
    Office of Public Health, Department for Health and Ageing, 11 Hindmarsh Square, Adelaide, SA 5000, Australia
    Aust N Z J Obstet Gynaecol 52:235-41. 2012
    ..Child bearing in the later reproductive years has become increasingly common in Australia with potential implications for clinical practice...
  35. ncbi Characteristics of women who are pregnant with their first baby at an advanced age
    Anne Britt Vika Nilsen
    Department of Women s and Children s Health, Karolinska Institutet, Stockholm, Sweden
    Acta Obstet Gynecol Scand 91:353-362x. 2012
    ..the background characteristics of women who gave birth to their first child at an advanced and very advanced maternal age, including their sociodemographic background, social relationships, health behavior, physical and mental health,..
  36. ncbi Women with reduced ovarian reserve or advanced maternal age have an altered follicular environment
    Leanne Pacella
    School of Pediatrics and Reproductive Health, Robinson Institute, University of Adelaide, Adelaide, South Australia, Australia
    Fertil Steril 98:986-94.e1-2. 2012
    To determine whether altered follicular environment is associated with ovarian reserve or maternal age.
  37. pmc Preeclampsia complicated by advanced maternal age: a registry-based study on primiparous women in Finland 1997-2008
    Reeta Lamminpää
    Department of Nursing Science, University of Eastern Finland, PO, Box, 1627, Kuopio, 70211, Finland
    BMC Pregnancy Childbirth 12:47. 2012
    ..One of the suggested risk factors for preeclampsia is advanced maternal age. In the Western countries, maternal age at first delivery has been steadily increasing, yet few studies have ..
  38. ncbi Recombination rate and reproductive success in humans
    Augustine Kong
    deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nat Genet 36:1203-6. 2004
    ..meioses each, and found a positive correlation between maternal recombination counts of an offspring and maternal age. We postulated that the recombination rate of eggs does not increase with maternal age, but that the apparent ..
  39. ncbi Association between spindle assembly checkpoint expression and maternal age in human oocytes
    N Steuerwald
    Gamete and Embryo Research Laboratory, Institute for Reproductive Medicine and Science of Saint Barnabas, West Orange, NJ 07052, USA
    Mol Hum Reprod 7:49-55. 2001
    ..The results obtained following quantitative analysis suggest that these messages degrade as oocytes age. Potentially, this may impair checkpoint function in older oocytes and may be a contributing factor in age-related aneuploidy...
  40. pmc Prevalence of smoking during pregnancy and associated risk factors among Canadian women: a national survey
    Ban Al-Sahab
    School of Kinesiology and Health Science, York University, Toronto, ON Canada M3J 1P3
    BMC Pregnancy Childbirth 10:24. 2010
    ..Therefore, the study aims to assess the prevalence of smoking during pregnancy and its associated risk factors throughout the Canadian provinces and territories...
  41. ncbi Comprehensive embryo analysis of advanced maternal age-related aneuploidies and mosaicism by short comparative genomic hybridization
    Mariona Rius
    Unitat de Biologia Cellular i Genetica Medica, Facultat de Medicina, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Fertil Steril 95:413-6. 2011
    ..short-CGH) method was used to perform a comprehensive cytogenetic study of isolated blastomeres from advanced maternal age embryos, discarded after fluorescent in situ hybridization (FISH) preimplantation genetic screening (PGS), ..
  42. ncbi Perinatal factors and the development of autism: a population study
    Emma J Glasson
    Schools of Population Health and Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Australia
    Arch Gen Psychiatry 61:618-27. 2004
    ..Some investigations have shown an association with obstetric complications but findings have been inconsistent owing to differences in sampling and methods...
  43. ncbi Assisted reproductive technologies (ART) in Canada: 2007 results from the Canadian ART Register
    Joanne Gunby
    Pegasus Technologies, Burlington, Ontario, Canada
    Fertil Steril 95:542-7.e1-10. 2011
    ..To present a report on assisted reproductive technologies (ART) cycles performed in 2007 in Canada and show trends in outcomes over time. This is the seventh annual report from the Canadian ART Register (CARTR)...
  44. ncbi Transcriptomic profiling of human oocytes: association of meiotic aneuploidy and altered oocyte gene expression
    E Fragouli
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK
    Mol Hum Reprod 16:570-82. 2010
    ..Aneuploidy is also closely related with advancing maternal age, a phenomenon not well understood...
  45. ncbi Epidemiology of congenital anomalies in a population-based birth registry in Taiwan, 2002
    Bing Yu Chen
    Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei 100, Taiwan
    J Formos Med Assoc 108:460-8. 2009
    ..We used the medical-practitioner-reported birth registry in 2002 to determine the occurrence of individual congenital anomalies and their associated risk factors, such as maternal age, fetal sex, and plurality.
  46. ncbi The maternal age-specific live birth prevalence of trisomies 13 and 18 compared to trisomy 21 (Down syndrome)
    George M Savva
    Department of Public Health and Primary Care, University of Cambridge, Institute of Public Health, Cambridge, UK
    Prenat Diagn 30:57-64. 2010
    To estimate the maternal age-specific live birth prevalence (in the absence of prenatal diagnosis and selective termination) of trisomy 13 (Patau syndrome) and trisomy 18 (Edwards syndrome) and compare it with that of trisomy 21 (Down ..
  47. ncbi Pregnancy outcome at extremely advanced maternal age
    Yariv Yogev
    Department of Obstetrics and Gynecology, Perinatal Division, Helen Schneider Hospital for Women, Rabin Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Am J Obstet Gynecol 203:558.e1-7. 2010
    The purpose of this study was to evaluate pregnancy outcome in women at extremely advanced maternal age (≥ 45 years).
  48. pmc Maternal smoking in pregnancy, fetal development, and childhood asthma
    Jouni J K Jaakkola
    Institute of Occupational Health, The University of Birmingham, Birmingham, United Kingdom
    Am J Public Health 94:136-40. 2004
    ..We examined the relationships among maternal smoking in pregnancy, fetal development, and the risk of asthma in childhood...
  49. ncbi Advancing maternal age is associated with increasing risk for autism: a review and meta-analysis
    Sven Sandin
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE 171 77 Stockholm, Sweden
    J Am Acad Child Adolesc Psychiatry 51:477-486.e1. 2012
    We conducted a meta-analysis of epidemiological studies investigating the association between maternal age and autism.
  50. pmc Polar body array CGH for prediction of the status of the corresponding oocyte. Part I: clinical results
    Joep Geraedts
    Department of Genetics and Cell Biology, Research Institute GROW, Faculty of Health, Medicine and Life Sciences, Maastricht University, PO Box 5800, Maastricht, AZ 6202, The Netherlands
    Hum Reprod 26:3173-80. 2011
    ..e. PGS by polar body (PB) biopsy, with whole genome amplification and microarray-based comparative genomic hybridization (array CGH) analysis...
  51. ncbi Cumulative incidence of type 1 diabetes in 10,168 siblings of Finnish young-onset type 1 diabetic patients
    Valma Harjutsalo
    Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, FIN 00300, Helsinki, Finland
    Diabetes 54:563-9. 2005
    ..This large prospective family study of type 1 diabetes in siblings of childhood-onset diabetic patients provides reliable empirical estimates for the sibling recurrence risk...
  52. pmc Late age at first full term birth is strongly associated with lobular breast cancer
    Polly A Newcomb
    University of Wisconsin Carbone Comprehensive Cancer Center, Madison, Wisconsin, USA
    Cancer 117:1946-56. 2011
    ..Late age at first full-term birth and nulliparity are known to increase breast cancer risk. The frequency of these risk factors has increased in recent decades...
  53. ncbi Maternal characteristics and lifestyle factors and the risk of delivering high birth weight infants
    Janne Ørskou
    Perinatal Epidemiological Research Unit, Department of Obstetrics and Gynaecology, Aarhus University Hospital, Aarhus, Denmark
    Obstet Gynecol 102:115-20. 2003
    ....
  54. ncbi Advancing paternal age and autism
    Abraham Reichenberg
    Department of Psychiatry and Seaver Center for Autism Research, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Arch Gen Psychiatry 63:1026-32. 2006
    ..Maternal and paternal ages are associated with neurodevelopmental disorders...
  55. ncbi Advanced maternal age and risk of antepartum and intrapartum stillbirth
    Hamisu M Salihu
    Department of Epidemiology and Biostatistics, University of South Florida, Tampa, Florida, USA
    J Obstet Gynaecol Res 34:843-50. 2008
    ..We sought to assess the risk of antepartum and intrapartum stillbirth subtypes among women of advanced age...
  56. ncbi Paternal age at birth and high-functioning autistic-spectrum disorder in offspring
    Kenji J Tsuchiya
    Osaka Hamamatsu Joint Research Center for Child Mental Development OHJRC CMD, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
    Br J Psychiatry 193:316-21. 2008
    ..Previous studies have reported the association between advanced paternal age at birth and the risk of autistic-spectrum disorder in offspring, including offspring with intellectual disability...
  57. ncbi Consanguinity and advanced maternal age as risk factors for reproductive losses in Alexandria, Egypt
    M M Mokhtar
    Department of Huiman Genetics, Medical Research Institute, Alexandria University, Egypt
    Eur J Epidemiol 17:559-65. 2001
    ..This study aimed at delineating the role of consanguinity and advanced maternal age on reproductive losses in Alexandria, Egypt...
  58. ncbi Mitochondrial aggregation patterns and activity in human oocytes and preimplantation embryos
    M Wilding
    Centre for Reproductive Biology, Clinica Villa del Sole, and Dipartimento Clinica di Emergenza Ginecologica e Ostetrica e Medicina della Riproduzione, Azienda Universitaria Policlinico, , Naples, Italy
    Hum Reprod 16:909-17. 2001
    ..The activity of mitochondria in fresh metaphase II oocytes was negatively correlated with maternal age. This trend continued when the activity of developing embryos was analysed...
  59. ncbi Cumulative live-birth rates after in vitro fertilization
    Beth A Malizia
    Boston IVF, Waltham, MA 02451, USA
    N Engl J Med 360:236-43. 2009
    ..Outcomes of in vitro fertilization (IVF) treatment are traditionally reported as pregnancies per IVF cycle. However, a couple's primary concern is the chance of a live birth over an entire treatment course...
  60. ncbi Childbearing beyond age 40: pregnancy outcome in 24,032 cases
    W M Gilbert
    Department of Obstetrics and Gynecology, Center for Health Services Research in Primary Care, University of California, Davis 95817, USA
    Obstet Gynecol 93:9-14. 1999
    ..To examine pregnancy outcomes in women age 40 or older...
  61. ncbi Restricted fetal growth in sudden intrauterine unexplained death
    J Frederik Frøen
    Department of Obstetrics and Gynecology, Rikshospitalet University Clinic, University of Oslo, Oslo, Norway
    Acta Obstet Gynecol Scand 83:801-7. 2004
    ....
  62. pmc Maternal age and risk of stillbirth: a systematic review
    Ling Huang
    Health Surveillance and Epidemiology Division, Centre for Health Promotion, Public Health Agency of Canada, Ottawa, Ont
    CMAJ 178:165-72. 2008
    ..Studies regarding the relation between older maternal age and the risk of stillbirth have yielded inconsistent conclusions...
  63. ncbi Risk factors for malaria infection and anemia for pregnant women in the Sahel area of Bandiagara, Mali
    Alassane Dicko
    Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto Stomatology, Malaria Research and Training Center, Bamako, Mali
    Acta Trop 89:17-23. 2003
    ..Thus, control measures against malaria infection should target younger rural women in their first trimester of pregnancy...
  64. ncbi Associations of parental, birth, and early life characteristics with systolic blood pressure at 5 years of age: findings from the Mater-University study of pregnancy and its outcomes
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Rd, Bristol, BS8 2PR, UK
    Circulation 110:2417-23. 2004
    ..We examined the associations of a range of parental and early life characteristics with systolic blood pressure at 5 years of age...
  65. ncbi Comparison of models of maternal age-specific risk for Down syndrome live births
    J K Morris
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Prenat Diagn 23:252-8. 2003
    To display and compare the different published formulae that specify the association between maternal age and the risk of a Down syndrome live birth.
  66. pmc SNP microarray-based 24 chromosome aneuploidy screening demonstrates that cleavage-stage FISH poorly predicts aneuploidy in embryos that develop to morphologically normal blastocysts
    L E Northrop
    Reproductive Medicine Associates of New Jersey, Morristown, NJ 07960, USA
    Mol Hum Reprod 16:590-600. 2010
    ..These findings support the conclusion that cleavage-stage FISH technology is poorly predictive of aneuploidy in morphologically normal blastocysts...
  67. pmc Optimal fetal growth for the Caucasian singleton and assessment of appropriateness of fetal growth: an analysis of a total population perinatal database
    Eve M Blair
    Centre for Child Health Research, The University of Western Australia, at the Telethon Institute for Child Health Research, P, O, Box 855, West Perth, WA, 6872, Australia
    BMC Pediatr 5:13. 2005
    ..Appropriateness of growth can then be inferred from the ratio of the value of the observed dimension to that of the optimal dimension...
  68. ncbi Pregnancy outcome at age 40 and older
    S Ziadeh
    Arch Gynecol Obstet 265:30-3. 2001
    ..Our purpose was to examine pregnancy outcomes among women age 40 or older...
  69. ncbi Trends in mode of delivery during 1984-2003: can they be explained by pregnancy and delivery complications?
    C M O'Leary
    Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, West Perth, Western Australia, Australia
    BJOG 114:855-64. 2007
    ..To describe trends in mode of delivery, to identify significant factors which affected mode of delivery, and to describe how these factors and their impact have changed over time...
  70. pmc The effect of maternal anthropometric characteristics and social factors on gestational age and birth weight in Sudanese newborn infants
    Eltahir M Elshibly
    Clinic of Neonatology Campus Charité Mitte, Universitatsmedizin Berlin, Germany
    BMC Public Health 8:244. 2008
    ..The aim of this study was to quantify the effect of maternal anthropometry, education and socio-economic status on gestational age and birth weight...
  71. ncbi Pregnancy outcome in primiparae of advanced maternal age
    Ilse Delbaere
    Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Eur J Obstet Gynecol Reprod Biol 135:41-6. 2007
    To investigate the impact of maternal age on singleton pregnancy outcome, taking into account intermediate and confounding factors.
  72. ncbi Abnormal placentation: twenty-year analysis
    Serena Wu
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Chicago, Ill, USA
    Am J Obstet Gynecol 192:1458-61. 2005
    ..This study was undertaken to determine whether the rate of abnormal placentation is increasing in conjunction with the cesarean rate and to evaluate incidence, risk factors, and outcomes...
  73. ncbi Smoking habits, nicotine use, and congenital malformations
    Maria M Morales-Suarez-Varela
    Unit of Public Health and Environmental Care, Department of Preventive Medicine, University of Valencia, Valencia, Spain
    Obstet Gynecol 107:51-7. 2006
    ..We examined whether maternal smoking and use of nicotine substitutes during the first 12 weeks of pregnancy increased the prevalence of congenital malformations in general and of certain congenital malformations in particular...
  74. ncbi Maternal age and malformations in singleton births
    L M Hollier
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Obstet Gynecol 96:701-6. 2000
    To examine the effect of maternal age on incidence of nonchromosomal fetal malformations.
  75. pmc Evidence that a defective spindle assembly checkpoint is not the primary cause of maternal age-associated aneuploidy in mouse eggs
    Francesca E Duncan
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Biol Reprod 81:768-76. 2009
    Advanced maternal age is unequivocally associated with increased aneuploidy in human eggs and infertility, but the molecular basis for this phenomenon is unknown...
  76. ncbi Factors influencing childbearing decisions and knowledge of perinatal risks among Canadian men and women
    Suzanne Tough
    Faculty of Medicine, University of Calgary, Room C4 301, 2888 Shaganappi Trail NW, Calgary, AB, T3B 6A8, Canada
    Matern Child Health J 11:189-98. 2007
    ..Little is known about men's and women's understanding of the maternal age related risks to pregnancy.
  77. ncbi Elective induction of labor as a risk factor for cesarean delivery among low-risk women at term
    A S Maslow
    Department of Clinical Outcomes and Quality Improvement, Franciscan Health System, Tacoma, Washington, USA
    Obstet Gynecol 95:917-22. 2000
    ..To determine the effects of elective induction on the risk of cesarean delivery in a cohort of women with low-risk term pregnancies and to evaluate the costs of elective induction services within our hospital system...
  78. ncbi Modifiable maternal exposures and offspring blood pressure: a review of epidemiological studies of maternal age, diet, and smoking
    Marie Jo A Brion
    Department of Social Medicine, University of Bristol, Bristol BS8 2PR, United Kingdom
    Pediatr Res 63:593-8. 2008
    ..The results of studies of maternal age varied and there was strong evidence of heterogeneity in the pooled analysis...
  79. ncbi To err (meiotically) is human: the genesis of human aneuploidy
    T Hassold
    Department of Genetics, Case Western Reserve University, 10, 900 Euclid Avenue, Cleveland, Ohio 44106, USA
    Nat Rev Genet 2:280-91. 2001
    ..However, recent molecular and cytogenetic approaches are now beginning to shed light on the non-disjunctional processes that lead to aneuploidy...
  80. ncbi Paternal age and intelligence: implications for age-related genomic changes in male germ cells
    Dolores Malaspina
    New York State Psychiatric Institute and Columbia University, New York, NY 10032, USA
    Psychiatr Genet 15:117-25. 2005
    ..There are also substantial genetic influences on intelligence, so de novo genetic events in male germ cells, which accompany advancing paternal age, may plausibly influence offspring intelligence...
  81. ncbi Dietary nitrites and nitrates, nitrosatable drugs, and neural tube defects
    Jean D Brender
    Department of Health Services Research, Texas State University at San Marcos, San Marcos, Texas 78666, USA
    Epidemiology 15:330-6. 2004
    ..Data are lacking on whether dietary intake of nitrates and nitrites modifies the association between maternal nitrosatable drug exposure and neural tube defects (NTDs) in offspring...
  82. ncbi Outcomes of pregnancies in women with pre-gestational diabetes mellitus and gestational diabetes mellitus; a population-based study in New South Wales, Australia, 1998-2002
    A W Shand
    School of Women s and Infants Health, The University of Western Australia, Perth, Australia
    Diabet Med 25:708-15. 2008
    ..To determine population-based rates and outcomes of pre-gestational diabetes mellitus (pre-GDM) and gestational diabetes mellitus (GDM) in pregnancy...
  83. ncbi Decline in human fertility rates with male age: a consequence of a decrease in male fecundity with aging?
    Roberto Matorras
    Human Reproduction Unit, Department of Obstetrics and Gynecology, Hospital de Cruces, Basque Country University, Baracaldo, Spain roberto matorras osakidetza net
    Gynecol Obstet Invest 71:229-35. 2011
    ..The objective of this study is to investigate the influence of male age on human fertility, defined as the birth rate for a given population...
  84. ncbi The impact of first trimester screening and early fetal anomaly scan on invasive testing rates in women with advanced maternal age
    A Hagen
    Obstetrics and Gynecology, Center for Prenatal Diagnosis Kudamm 199, Berlin
    Ultraschall Med 32:302-6. 2011
    ..To evaluate the acceptance of noninvasive screening for trisomy 13, 18, 21 and the impact on invasive testing rates in women at an age≥35 years...
  85. ncbi Family planning, fertility awareness and knowledge about Italian legislation on assisted reproduction among Italian academic students
    Valentina Rovei
    Reproductive Medicine and IVF Unit, Department of Obstetrical and Gynaecological Sciences, University of Torino, St Anna Hospital, Torino, Italy
    Reprod Biomed Online 20:873-9. 2010
    Over the last century, most industrialized countries have experienced a progressive increase in maternal age at first pregnancy and a reduction of fertility rate, with important social and economic consequences...
  86. ncbi Impact of maternal age on the incidence of obstetrical complications in Japan
    Yoshio Matsuda
    Department of Obstetrics and Gynecology, Tokyo Women s Medical University, Shinjuku ku, Tokyo
    J Obstet Gynaecol Res 37:1409-14. 2011
    To clarify the effect of maternal age on obstetrical complications through a cohort and case-cohort study.
  87. ncbi Diminished effect of maternal age on implantation after preimplantation genetic diagnosis with array comparative genomic hybridization
    Gary L Harton
    Bluegnome, La Jolla, California Electronic address
    Fertil Steril 100:1695-703. 2013
    To assess the relationship between maternal age, chromosome abnormality, implantation, and pregnancy loss.
  88. ncbi Maternal aging and chromosomal abnormalities: new data drawn from in vitro unfertilized human oocytes
    Franck Pellestor
    CNRS UPR1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Hum Genet 112:195-203. 2003
    The effect of maternal age on the incidence of chromosomal abnormalities was investigated on a large sample of 3,042 in vitro unfertilized human oocytes II obtained from 792 women aged 19-46 years and participating in an in vitro ..
  89. pmc Differences in late fetal death rates in association with determinants of small for gestational age fetuses: population based cohort study
    S Cnattingius
    Department of Medical Epidemiology, Karolinska Institute, S 171 77 Stockholm, Sweden
    BMJ 316:1483-7. 1998
    ..To examine differences in late fetal death rates in association with determinants of small for gestational age fetuses...
  90. ncbi Trends and geographic inequalities in the prevalence of Down syndrome in Europe, 1980-1999
    H Dolk
    EUROCAT Central Registry, Room 15E12, Faculty of Life and Health Sciences, University of Ulster at Jordanstown, Shore Rd, Newtownabbey BT37 OQB, Ulster, UK
    Rev Epidemiol Sante Publique 53:2S87-95. 2005
    ..In this paper, we aim to examine trends in the live birth prevalence of Down syndrome in Europe in the light of trends in maternal age and in prenatal diagnosis.
  91. ncbi Development of heart block in children of SSA/SSB-autoantibody-positive women is associated with maternal age and displays a season-of-birth pattern
    Aurelie Ambrosi
    Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Ann Rheum Dis 71:334-40. 2012
    ..The authors investigated the influence of other maternal and fetal factors on heart block development in a Swedish population-based cohort...
  92. pmc Autism and intellectual disability are differentially related to sociodemographic background at birth
    Helen Leonard
    Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, West Perth, Western Australia, Australia
    PLoS ONE 6:e17875. 2011
    ..Research findings investigating the sociodemographics of autism spectrum disorder (ASD) have been inconsistent and rarely considered the presence of intellectual disability (ID)...
  93. pmc Age-dependent recombination rates in human pedigrees
    Julie Hussin
    Department of Biochemistry, Faculty of Medicine, University of Montreal, Montreal, Canada
    PLoS Genet 7:e1002251. 2011
    In humans, chromosome-number abnormalities have been associated with altered recombination and increased maternal age. Therefore, age-related effects on recombination are of major importance, especially in relation to the mechanisms ..
  94. ncbi Comparison of obstetric outcomes in recipients of donor oocytes vs. women of advanced maternal age with autologous oocytes
    Melinda B Henne
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA
    J Reprod Med 52:585-90. 2007
    To evaluate obstetric complications in women conceiving with donated oocytes as compared to controls of advanced maternal age.
  95. ncbi Age at first birth, mode of conception and psychological wellbeing in pregnancy: findings from the parental age and transition to parenthood Australia (PATPA) study
    C A McMahon
    Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, NSW 2109, Australia
    Hum Reprod 26:1389-98. 2011
    ..We aimed to describe the context of pregnancy for first-time mothers of different ages and examine relationships among maternal age at first birth, mode of conception and psychosocial wellbeing in pregnancy.
  96. ncbi Paternal age at birth of first child and risk of schizophrenia
    Liselotte Petersen
    National Centre for Register Based Research, Aarhus University, Denmark
    Am J Psychiatry 168:82-8. 2011
    ..The authors aimed to distinguish between these two measures of paternal age...
  97. ncbi A cost-effectiveness analysis of in-vitro fertilization by maternal age and number of treatment attempts
    Alison Griffiths
    NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, NSW 2050, Australia
    Hum Reprod 25:924-31. 2010
    ..A decision analytic model was designed to estimate the incremental cost-effectiveness of IVF by additional treatment programmes and maternal age.
  98. pmc Temporal changes in key maternal and fetal factors affecting birth outcomes: a 32-year population-based study in an industrial city
    Svetlana V Glinianaia
    Institute of Health and Society, Newcastle University, William Leech Building, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    BMC Pregnancy Childbirth 8:39. 2008
    ..The objective of this study was to describe temporal changes in key maternal and fetal factors affecting birth outcomes in Newcastle upon Tyne over three decades, 1961-1992...
  99. pmc Advanced maternal age: are decisions about the timing of child-bearing a failure to understand the risks?
    Karen M Benzies
    Faculty of Nursing, University of Calgary, Calgary, Alta
    CMAJ 178:183-4. 2008
  100. pmc Maternal age and chromosomally abnormal pregnancies: what we know and what we wish we knew
    Terry Hassold
    School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, Washington 99164, USA
    Curr Opin Pediatr 21:703-8. 2009
    The relationship between increasing maternal age and trisomy has been recognized for over 50 years and is one of the most important etiological factors associated with any human genetic disorder...

Research Grants67

  1. Genome-wide recombination as a risk factor for nondisjunction
    NATASHA D HOLLIS; Fiscal Year: 2010
    ..It has been shown that altered patterns of recombination and maternal age are risk factors for nondisjunction...
  2. Parental age at birth and risk of adult-onset cancer in female offspring
    Yani Lu; Fiscal Year: 2013
    ..The immediate effects of advanced maternal age (e.g., chromosomal abnormalities) and paternal age (e.g...
  3. Tissue recovery in the pathophysiology of stress urinary incontinence
    Adonis K Hijaz; Fiscal Year: 2013
    ..In several recent epidemiological studies, advanced maternal age has been reported as a plausible risk factor for development of SUI following birth trauma...
  4. CONTROL OF MEIOSIS AND GERMLINE PROLIFERATION
    DAVID IRWIN GREENSTEIN; Fiscal Year: 2012
    ..elegans will define the signaling mechanisms controlling late events in oogenesis and provide insights into how they may go awry when signaling is perturbed. ..
  5. PERCHLORATE AND THYROID HORMONES IN PREGNANCY AND INFANTS IN SOUTHERN CALIFORNIA
    Craig M Steinmaus; Fiscal Year: 2013
    ..Data on maternal age, education, infant gender, birth weight, socioeconomic status, race/ethnicity, smoking, and other questionnaire ..
  6. Climate Change and Health: Assessing the Risk of Preterm Delivery
    Rupa Basu; Fiscal Year: 2013
    ..The analyses will be stratified by season, and also by maternal race/ethnic group, maternal age, and socioeconomic status...
  7. Pre-existing Diabetes and Pregnancy
    Caitlin A Knox; Fiscal Year: 2013
    ..Common demographic variables (e.g., maternal age, education level, race/ethnicity, and geographic location) as well as clinical characteristics (e.g...
  8. Age and molecular mechanisms contributing to aneuploidy in oocytes
    Richard M Schultz; Fiscal Year: 2013
    ..Most aneuplodies associated with increased maternal age are due to non-disjunction and meiotic errors that occur during meiosis...
  9. Type 2 Diabetes Risk in Women With Gestational Diabetes
    Catherine Kim; Fiscal Year: 2010
    ..These projects address the growing incidence of GDM, which is increasing due to advancing maternal age and obesity, as well as the increasing rates of DM, a major public health problem.
  10. Genetic Analysis of Human First Trimester Trophoblast in Ongoing Pregnancies
    Michael Peter Diamond; Fiscal Year: 2013
    ..be utilized to anticipate genetic disorders brought about by heredity or chromosomal errors that increase with maternal age. The most common methods of retrieving fetal tissue for prenatal diagnosis, amniocentesis and chorionic villous ..
  11. THE GENETIC ARCHITECTURE OF CONGENITAL HEART DISEASE
    Patrick Y Jay; Fiscal Year: 2013
    ..In addition, one cross replicates the commonly reported human epidemiologic association of older maternal age with an increased risk of congenital heart defects independent of any chromosomal abnormality...
  12. QuitAdvisorOB: A tool for delivering smoking cessation guidance to pregnant women
    Jamie L Studts; Fiscal Year: 2012
    ..women of child-bearing age generally ranges between 17 and 35 percent worldwide, and is heavily influenced by maternal age, ethnicity, education, and socioeconomic level...
  13. Structure and Function of a Eukaryotic Centromere
    Kerry S Bloom; Fiscal Year: 2013
    ..the inability to bind meiotic chromosomes together has been directly linked to mechanisms responsible for the maternal age affect wherein the probability of a trisomic pregnancy increases from 2% to 35% by the age of 40...
  14. Nested case-control study of maternal herpes viruses in relation to gastroschisis
    Martha M Werler; Fiscal Year: 2013
    ..mothers and have been linked to gastroschisis risk, they do not account for the strong inverse relation with maternal age. The epidemiologic characteristics of gastroschisis suggest an infectious agent may be in the developmental ..
  15. Regulation of Chromosome Cohesion during Cell Cycle Progression
    Susannah Rankin; Fiscal Year: 2013
    ..Failures in cohesion are thought to underlie the maternal age-related increase in aneuploid eggs, a major cause of birth defects and spontaneous abortion...
  16. Quasi-experimental studies of early risk factors for severe psychopathology
    Paul Lichtenstein; Fiscal Year: 2013
    ..risk for these severe problems, including maternal smoking during pregnancy, maternal stress during pregnancy, maternal age at childbearing, and advancing paternal age at childbearing...
  17. Genome-wide recombination profiles in oocytes with chromosome 21 nondisjunction
    Stephanie L Sherman; Fiscal Year: 2010
    ..Based on these results, we will be able to focus/re-focus our search for risk factors in the context of maternal age and recombination patterns...
  18. Recombination rate variation and evolution in primates
    MOLLY F PRZEWORSKI; Fiscal Year: 2013
    ..In Aim 3, we plan to examine how variation in recombination rates and maternal age influence the risk of aneuploidy. In Aim 3...
  19. Premature Uterine Ageing and Preterm Delivery
    Jeeyeon Cha; Fiscal Year: 2013
    ..Since increased maternal age is a risk factor for preterm labor in women and since p53 function declines in ageing mice, premature uterine ..
  20. Segregation of error-prone chromosomes in meiosis
    Dean S Dawson; Fiscal Year: 2010
    ..The incidence of conceptuses with inappropriate numbers of chromosomes rises with increased maternal age. Recombination between homologous chromosomes greatly increases the probability that they will segregate ..
  21. Patients, Clincs, and Systems: Screening for Alcohol Use
    Grace Chang; Fiscal Year: 2010
    ..such as substance use and sexual activity cluster together, componding the biologic risk inherent in young maternal age and the adverse social consequences of adolescent pregnancy...
  22. Aging and Ovarian Stem Cell Niche Dysfunction
    Ning Wang; Fiscal Year: 2012
    ..activity when it would be desirable - such as in patients with premature ovarian failure, in women of advanced maternal age (to postpone age- related ovarian failure and menopause) or in female cancer patients (to rescue their ovarian ..
  23. Aging and Ovarian Stem Cell Niche Dysfunction
    Ning Wang; Fiscal Year: 2013
    ..activity when it would be desirable - such as in patients with premature ovarian failure, in women of advanced maternal age (to postpone age- related ovarian failure and menopause) or in female cancer patients (to rescue their ovarian ..
  24. Mediating Factors in the Relationship between Obesity and Poor Lactation Outcomes
    LAURIE ANN NOMMSEN RIVERS; Fiscal Year: 2010
    ..n=405 breastfeeding women with complete data;32% obese) were greater maternal body mass index, older maternal age, greater infant birth weight, and use of infant formula...
  25. Control of Meiotic Spindle Assembly in Mammalian Oocytes
    Maria M Viveiros; Fiscal Year: 2012
    ..errors in chromosome segregation that occur during meiotic division in oocytes, and increase significantly with maternal age. Chromosome segregation is critically dependent on assembly of the microtubule spindle apparatus as well as the ..
  26. MICRONUTRIENTS AND MOTHER TO CHILD TRANSMISSION OF HIV
    Richard Semba; Fiscal Year: 2001
    ..03). Vitamin A significantly reduced low birth weight in a multivariate analysis controlling for maternal age, body mass index, and CD4+ count...
  27. COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
    Sandra Carson; Fiscal Year: 1990
    ..Confounding variables (e.g., maternal age, previous losses smoking, alcohol intake) will be recorded, and subjects then randomized to progesterone or ..
  28. Clinical Measures to Lower Genital Tract Trauma at Birth
    Leah Albers; Fiscal Year: 2004
    ..three strategies on the likelihood of an intact perineum after birth, with control for confounding variables (maternal age and parity, birth position, style of pushing, size and position of baby at birth, length of second stage, and ..
  29. Maternal Morbidity and Mortality in Multiple Pregnancy
    Barbara Luke; Fiscal Year: 2006
    ..are limited, though, by their small sample sizes and frequent failure to control for the confounding factors of maternal age and parity...
  30. Neural Bases of Eyeblink Conditioning in FASD
    Sandra W Jacobson; Fiscal Year: 2012
    ..The moderating effects of maternal age, alcohol abuse history, and variants of the ADH1B polymorphism on the child's vulnerability to FASD will ..
  31. Epigentics and Female Reproductive Cancers
    MARY COLETTE PERRIN; Fiscal Year: 2012
    ..1 will also explore the epidemiology these phenomena focusing in particular on paternal and maternal age. Studying X-chromosome inactivation and loss of imprinting at IGF2 and their association with breast and ..
  32. PRENATAL DOWN SYNDROME SCREENING
    Rachel Fisher; Fiscal Year: 1993
    ..The risk of delivering a baby with Down syndrome (DS) increases with increasing maternal age [2]. By offering amniocentesis to women 35 and over, approximately 20% of DS pregnancies can be detected...
  33. Plurality and Contemporary Infant Mortality Risks
    Barbara Luke; Fiscal Year: 2006
    ..Older maternal age requires more aggressive therapies to achieve a pregnancy, including transferring more embryos...
  34. COMPARISON OF CHORION VILLUS SAMPLING AND AMNIOCENTESIS
    ROBERT DESNICK; Fiscal Year: 1990
    ..induced abortion material or specimens obtained from newborns monitored for indications other than advanced maternal age. Clinical evaluations will be performed on all monitored infants in the newborn nursery and at 6 months of age...
  35. NOVEL EVALUATION OF LACTATION PERFORMANCE
    Cutberto Garza; Fiscal Year: 1991
    ..the contexts of these assessments associations have been sought most commonly between lactation performance and maternal age, maternal nutritional status, length of pregnancy, duration of lactation, lactation management protocols, and ..
  36. THE BIODEMOGRAPHY OF HUMAN LONGEVITY--A TRAINING PROGRAM
    Leonid Gavrilov; Fiscal Year: 2005
    ..importance of mutation load on the paternal X chromosome inherited by daughters only); (2) to analyze the maternal age effects on offspring longevity (in relation to the possible role of age-related accumulation of oxidative ..
  37. CHROMOSOME PAIRING AND NONDISJUNCTION IN HUMAN MEIOSIS
    Edith Cheng; Fiscal Year: 2000
    ..that have been proposed to explain the high incidence of aneuploidy in female gametes and the related maternal age effect...
  38. Advanced Reproductive Technology and Infant Health
    Marianne Bitler; Fiscal Year: 2005
    ..impacts of ART use and of state-mandated insurance coverage of infertility treatment on the number of births, maternal age at birth, and the incidence of multiple births, using both the NSFG and Vital Statistics birth certificate data;..
  39. EARLY ADVERSITY: DEVELOPMENTAL PATHWAYS TO ADOLESCENT DRINKING
    Marie D Cornelius; Fiscal Year: 2013
    ..status during pregnancy, offspring exposure to child maltreatment, and sociodemographic factors including maternal age. In early childhood, measures of the environment, maternal psychological status, substance use, and ..
  40. Spontaneous Arousals in "CHIME" Infants at Risk for SIDS
    ROBERT DARNALL; Fiscal Year: 2006
    ..In addition, important demographic data were collected including maternal age, cigarette smoking, and alcohol use...
  41. IN SITU HYBRIDIZATION IN PRENATAL DIAGNOSIS
    Kenneth Castleman; Fiscal Year: 1993
    ..of these five chromosomes occur in approximately 2% of all prenatal diagnostic tests done for "advanced maternal age", and account for the great majority of all viable cytogenetic abnormalities observed at amniocentesis or CVS...
  42. ULTRASOUND SCREENING AND RISK ASSESSMENT OF PREGNANCY
    Fredric Frigoletto; Fiscal Year: 1993
    ..Eligibility for the study as well as risk factors for pregnancy outcome such as maternal age, socioeconomic status, prior obstetrical history, prepregnancy weight and nutrition, active and passive smoking,..
  43. DIET, IMMUNE MODULATION, AND ASTHMA IN EARLY LIFE
    Scott Weiss; Fiscal Year: 2002
    ..potentially influential host and environmental factors to be examined include: parental asthma history, maternal age, perinatal history, acute lower respiratory illness history, day care, environmental tobacco smoke, birthweight,..
  44. Advanced Reproductive Age and Environmental Health
    Stephanie Engel; Fiscal Year: 2007
    ..We propose to enroll 200 women of advanced maternal age (AMA) in a prospective pregnancy cohort, and to assemble a repository of maternal biological specimens ..
  45. ROLE OF DIETARY N-3 FATTY ACIDS IN PREMATURE INFANTS
    Susan Carlson; Fiscal Year: 1992
    ..neonatal/perinatal variables such as birth wt, gestational age, age at enrollment, O2, ventilatory support, maternal age and gravida...
  46. The Epidemiology of Hospitalized Postpartum Depression
    David Savitz; Fiscal Year: 2009
    ..cases and appears to disproportionately afflict socioeconomically disadvantaged women at the extremes of the maternal age distribution...
  47. A Pilot Study of Novel Candidate Genes for Preeclampsia
    Sue Ingles; Fiscal Year: 2005
    ..their first pregnancy with a specific partner) and controls with a normotensive pregnancy history, matched on maternal age, race, gestational age and year/month of delivery...
  48. PREGNANT ADDICTS AND OFFSPRING: EVALUATING INTERVENTION
    Judy Howard; Fiscal Year: 1993
    ..of intervention, and 110, comparable with respect to socioeconomic status, ethnicity, years of education, maternal age, parity and marital status, will be randomly assigned to the control group receiving referrals to exist ..
  49. Impact of Intrauterine Tobacco Smoke Exposure on Umbilical Cord Blood Stem Cells
    JENNIFER KORNOSKY; Fiscal Year: 2009
    ..Regression models that control for potential confounders such as serum folate, maternal age, parity, race/ethnicity, body mass index status, previous IUGR/fetal death, and fetal gender will be developed ..
  50. BIRTHWEIGHT AND GESTATIONAL AGE AND CHRONIC DISEASE RISK
    Tim Byers; Fiscal Year: 2000
    ..The analysis will account for potential confounding and effect-modifying factors, including race/ethnicity, maternal age, and smoking...
  51. RANDOMIZED TRIAL OF 11-14 WEEK AMNIOCENTESIS AND TA CVS
    Elizabeth Thom; Fiscal Year: 1999
    ..healthy pregnant women at 77 to 104 days gestation, whose only indication for prenatal diagnosis is advanced maternal age of at least 34 years at enrollment or trisomy in a previous pregnancy will be randomized to receive either TA ..
  52. Metotic Spindle Assembly and Aneuploidy in Mammals
    Duane Compton; Fiscal Year: 2003
    ..One of the strongest predictors of aneuploidy is maternal age with nearly half of all oocytes ovulated in women over age 40 containing errors in chromosome number...
  53. Genetic Counseling Processes and Analogue Client Outcome
    Debra Roter; Fiscal Year: 2006
    ..trained simulated clients seeking services related to either a) prenatal test counseling for advanced maternal age and a positive family history for cystic fibrosis, or b) susceptibility testing for BRCA1 and BRCA2 gene ..
  54. STATISTICAL METHODS FOR NONDISJUNCTION DATA
    Hongyu Zhao; Fiscal Year: 2001
    ..b>Maternal age is well recognized as a major risk factor for chromosome abnormalities...
  55. ENERGETICS, NURSING BEHAVIOR, AND LACTATIONAL AMENORRHEA
    Peter Ellison; Fiscal Year: 2000
    ..Also, maternal age is postulated to have a U-shaped relationship with on lactational infertility...
  56. BOSTONS CASE CONTROL STUDIES OF INFANT DEATH AND VLBW
    Karen Power; Fiscal Year: 1991
    ..death and VLBW infants will be identified and frequency matched to controls on Race, census tract cluster and maternal age. This sampling scheme is designed to permit us to focus on groups that we expect to have poor outcomes...
  57. Germ Cell Aging
    CHRISTI WALTER; Fiscal Year: 2007
    Advanced paternal age is less well publicized than advanced maternal age, but paternal age can also have a significant impact on reproductive health...
  58. HOSPITAL & REGIONAL FACTORS IN C-SECTION RATE VARIATIONS
    Laura Gardner; Fiscal Year: 1991
    ..discharge data for the full five year study period, including the following variables: service hospital, maternal age, diagnostic codes, procedure codes, source of payment, past obstetrical history of the mother and designation ..
  59. PROXIMATE DETERMINANTS OF LBW AND INFANT MORTALITY
    ARLINE GERONIMUS; Fiscal Year: 1993
    ..Black/white differentials in poor birth outcomes also increase with maternal age. The differences in women's health may be important mechanisms driving the black/white infant mortality ..
  60. Enhancing Patient Prenatal Education-A Feasibility Study
    James Sorenson; Fiscal Year: 2003
    ..ICAI) patient education program for six prenatal genetic carrier screening tests (Multiple-Marker, Advanced Maternal Age, Sickle Cell, Thalassemia, Cystic Fibrosis, and Tay Sachs/Canavan)...
  61. INFANT DEVELOPMENT OUTCOMES OF PRENATAL COCAINE EXPOSURE
    HAROLD BAUER; Fiscal Year: 1992
    ..and at 6, 12, & 18 months of age of 20 cocaine exposed and 20 matched (for newborn IVH & sex, maternal age, SES, parity, & ethically) non-cocaine exposed infants to determine vocal differences and communication ..
  62. MATERNAL RISK FACTORS FOR J ORRP IN DENMARK
    Keerti Shah; Fiscal Year: 2001
    ..Factors that may influence the transmission of JORRP (virus type in condyloma, maternal age, parity, medical intervention and others) will be identified...
  63. Intrapartum complications and neurologic morbidity
    Vera Ehrenstein; Fiscal Year: 2006
    ..Risk ratios are examined in the groups according to birth weight, mode of delivery, birth presentation, maternal age at delivery, and smoking...
  64. New Predictors of Adolescent Preterm Delivery
    Catherine Stevens Simon; Fiscal Year: 2006
    ..cytotrophoblastic stem cell differentiation with the goals of establishing a mechanistic link between young maternal age, abnormal placentation and, pre-term delivery and generating testable new hypotheses about therapeusis...
  65. EARLY LIFE RISK FACTORS FOR ALZHEIMERS DISEASE
    Walter Kukull; Fiscal Year: 1999
    ..brain then measures of early growth: low level of father's occupation, increase number of siblings, and maternal age should be associated with AD...
  66. EARLY INTERACTIVE PROCESSES: MOTHER/INFANT ADAPTATION
    MARGUERITE BARRATT; Fiscal Year: 1999
    ..The sample represents a diverse cross section of the population varying in maternal age, marital status, and SES...
  67. YOUNG MATERNAL AGE, INFANT HEALTH, AND HEALTH CARE USE
    Donna Strobino; Fiscal Year: 1990
    The objective of the research is to investigate the effect of a young maternal age on infant health and preventive health care utilization...