age factors


Summary: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.

Top Publications

  1. pmc Establishing a standard definition for child overweight and obesity worldwide: international survey
    T J Cole
    Department of Epidemiology and Public Health, Institute of Child Health, London WC1N 1EH
    BMJ 320:1240-3. 2000
  2. pmc Body mass index cut offs to define thinness in children and adolescents: international survey
    Tim J Cole
    Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London WC1N 1EH
    BMJ 335:194. 2007
  3. pmc Cancer survival in Australia, Canada, Denmark, Norway, Sweden, and the UK, 1995-2007 (the International Cancer Benchmarking Partnership): an analysis of population-based cancer registry data
    M P Coleman
    Cancer Research UK Cancer Survival Group, London School of Hygiene and Tropical Medicine, London, UK
    Lancet 377:127-38. 2011
  4. pmc Accelerated telomere shortening in response to life stress
    Elissa S Epel
    Department of Psychiatry, University of California, 3333 California Street, Suite 465, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 101:17312-5. 2004
  5. ncbi Prevalence, expenditures, and complications of multiple chronic conditions in the elderly
    Jennifer L Wolff
    Department of Health Policy and Management, The Johns Hopkins University Bloomberg School of Public Health, 624 N Broadway, Room 304, Baltimore, MD 21205, USA
    Arch Intern Med 162:2269-76. 2002
  6. pmc The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
    Am J Psychiatry 163:716-23. 2006
  7. ncbi Cardiovascular morbidity and mortality associated with the metabolic syndrome
    B Isomaa
    Department of Internal Medicine, Jakobstad Hospital, Finland
    Diabetes Care 24:683-9. 2001
  8. ncbi A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group
    A S Levey
    New England Medical Center, Boston, MA 02111, USA
    Ann Intern Med 130:461-70. 1999
  9. ncbi Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis
    Silvia de Sanjose
    Servei d Epidemiologia i Registre del Cancer, Institut Catala d Oncologia, Barcelona, Spain
    Lancet Infect Dis 7:453-9. 2007
  10. ncbi Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability
    Ian Janssen
    School of Physical and Health Education, Queen s University, Kingston, Ontario, Canada
    J Am Geriatr Soc 50:889-96. 2002

Detail Information

Publications280 found, 100 shown here

  1. pmc Establishing a standard definition for child overweight and obesity worldwide: international survey
    T J Cole
    Department of Epidemiology and Public Health, Institute of Child Health, London WC1N 1EH
    BMJ 320:1240-3. 2000
    ..To develop an internationally acceptable definition of child overweight and obesity, specifying the measurement, the reference population, and the age and sex specific cut off points...
  2. pmc Body mass index cut offs to define thinness in children and adolescents: international survey
    Tim J Cole
    Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London WC1N 1EH
    BMJ 335:194. 2007
    ..To determine cut offs to define thinness in children and adolescents, based on body mass index at age 18 years...
  3. pmc Cancer survival in Australia, Canada, Denmark, Norway, Sweden, and the UK, 1995-2007 (the International Cancer Benchmarking Partnership): an analysis of population-based cancer registry data
    M P Coleman
    Cancer Research UK Cancer Survival Group, London School of Hygiene and Tropical Medicine, London, UK
    Lancet 377:127-38. 2011
    ..This is the first study in a programme to investigate international survival disparities, with the aim of informing health policy to raise standards and reduce inequalities in survival...
  4. pmc Accelerated telomere shortening in response to life stress
    Elissa S Epel
    Department of Psychiatry, University of California, 3333 California Street, Suite 465, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 101:17312-5. 2004
    ..These findings have implications for understanding how, at the cellular level, stress may promote earlier onset of age-related diseases...
  5. ncbi Prevalence, expenditures, and complications of multiple chronic conditions in the elderly
    Jennifer L Wolff
    Department of Health Policy and Management, The Johns Hopkins University Bloomberg School of Public Health, 624 N Broadway, Room 304, Baltimore, MD 21205, USA
    Arch Intern Med 162:2269-76. 2002
    ..The prevalence, health care expenditures, and hospitalization experiences are important considerations among elderly populations with multiple chronic conditions...
  6. pmc The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
    Am J Psychiatry 163:716-23. 2006
    ..Despite growing interest in adult attention deficit hyperactivity disorder (ADHD), little is known about its prevalence or correlates...
  7. ncbi Cardiovascular morbidity and mortality associated with the metabolic syndrome
    B Isomaa
    Department of Internal Medicine, Jakobstad Hospital, Finland
    Diabetes Care 24:683-9. 2001
    ..To estimate the prevalence of and the cardiovascular risk associated with the metabolic syndrome using the new definition proposed by the World Health Organization..
  8. ncbi A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group
    A S Levey
    New England Medical Center, Boston, MA 02111, USA
    Ann Intern Med 130:461-70. 1999
    ..Serum creatinine concentration is widely used as an index of renal function, but this concentration is affected by factors other than glomerular filtration rate (GFR)...
  9. ncbi Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis
    Silvia de Sanjose
    Servei d Epidemiologia i Registre del Cancer, Institut Catala d Oncologia, Barcelona, Spain
    Lancet Infect Dis 7:453-9. 2007
    ..The HPV types most commonly detected are similar to those most commonly described in pre-neoplastic and cancer cases, although the relative contribution of HPV16 and HPV18 is substantially lower in cytologically normal women...
  10. ncbi Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability
    Ian Janssen
    School of Physical and Health Education, Queen s University, Kingston, Ontario, Canada
    J Am Geriatr Soc 50:889-96. 2002
    ..To establish the prevalence of sarcopenia in older Americans and to test the hypothesis that sarcopenia is related to functional impairment and physical disability in older persons...
  11. ncbi Prevalence and development of psychiatric disorders in childhood and adolescence
    E Jane Costello
    Department of Psychiatry and Behavioral Sciences, Duke University Medical School, Durham, NC 27710, USA
    Arch Gen Psychiatry 60:837-44. 2003
    ..This longitudinal community study assessed the prevalence and development of psychiatric disorders from age 9 through 16 years and examined homotypic and heterotypic continuity...
  12. pmc Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer
    Andrew E Teschendorff
    University College London, London WC1E 6BT, UK
    Genome Res 20:440-6. 2010
    ..These findings shed substantial novel insights into the epigenetic effects of aging and support the view that age may predispose to malignant transformation by irreversibly stabilizing stem cell features...
  13. pmc The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994
    Yong Woo Park
    Department of Family Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea
    Arch Intern Med 163:427-36. 2003
    ..The extent to which the metabolic syndrome is associated with demographic and potentially modifiable lifestyle factors in the US population is unknown...
  14. ncbi The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies
    Stephen V Faraone
    Medical Genetics Research Program and Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Psychol Med 36:159-65. 2006
    ..This study examined the persistence of attention deficit hyperactivity disorder (ADHD) into adulthood...
  15. pmc Multimorbidity patterns in the elderly: a new approach of disease clustering identifies complex interrelations between chronic conditions
    Ingmar Schafer
    Department of Primary Medical Care, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 5:e15941. 2010
    ..The aim of this study was to increase the knowledge of specific processes of multimorbidity in an unselected elderly population by identifying patterns of statistically significantly associated comorbidity...
  16. pmc Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice
    Michelle Gray
    Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 28:6182-95. 2008
    ..In summary, the BACHD model constitutes a novel and robust in vivo paradigm for the investigation of HD pathogenesis and treatment...
  17. pmc Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies
    Xiaohong R Yang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Sciences, Rockville, MD 20852, USA
    J Natl Cancer Inst 103:250-63. 2011
    ..Previous studies have suggested that breast cancer risk factors are associated with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors...
  18. ncbi Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review
    Valery L Feigin
    National Research Centre for Stroke, Applied Neurosciences and Neurorehabilitation, School of Rehabilitation and Occupation Studies, AUT University, North Shore Campus, AA254, Northcote 0627, Auckland 1142, New Zealand
    Lancet Neurol 8:355-69. 2009
    ..The time to decide whether or not stroke is an issue that should be on the governmental agenda in low to middle income countries has now passed. Now is the time for action...
  19. pmc Genome-wide association studies identify loci associated with age at menarche and age at natural menopause
    Chunyan He
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Genet 41:724-8. 2009
    ..42 (in or near the gene BRSK1), 5q35.2 (in or near genes UIMC1 and HK3) and 6p24.2 (in the gene SYCP2L). These newly identified loci might expand understanding of the biological pathways regulating these two traits...
  20. ncbi Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant
    R A Wolfe
    U S Renal Data System Coordinating Center, Department of Biostatistics, University of Michigan, Ann Arbor 48103, USA
    N Engl J Med 341:1725-30. 1999
  21. ncbi The effect of influenza on hospitalizations, outpatient visits, and courses of antibiotics in children
    K M Neuzil
    Department of Medicine, University of Washington School of Medicine, Seattle, USA
    N Engl J Med 342:225-31. 2000
    ..We measured the disease burden of influenza in a large cohort of healthy children in the Tennessee Medicaid program who were younger than 15 years of age...
  22. pmc Age-patterns of malaria vary with severity, transmission intensity and seasonality in sub-Saharan Africa: a systematic review and pooled analysis
    Ilona Carneiro
    Disease Control and Vector Biology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 5:e8988. 2010
    ..We have, therefore, undertaken a pooled analysis of existing data from multiple sites to enable a comprehensive overview of the age-patterns of malaria outcomes under different epidemiological conditions in sub-Saharan Africa...
  23. ncbi Impact of atrial fibrillation on the risk of death: the Framingham Heart Study
    E J Benjamin
    National Heart, Lung, and Blood Institute s Framingham Heart Study, National Institutes of Health, Mass, USA
    Circulation 98:946-52. 1998
    ..Atrial fibrillation (AF) causes substantial morbidity. It is uncertain whether AF is associated with excess mortality independent of associated cardiac conditions and risk factors...
  24. ncbi The completeness of the Swedish Cancer Register: a sample survey for year 1998
    Lotti Barlow
    Centre for Epidemiology, The National Board of Health and Welfare, Stockholm, Sweden
    Acta Oncol 48:27-33. 2009
    ..The aim of the study was to estimate the overall coverage of malignant cancer cases in 1998 and to reveal possible reasons behind non-reporting...
  25. ncbi Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arch Gen Psychiatry 62:593-602. 2005
    ..Little is known about lifetime prevalence or age of onset of DSM-IV disorders...
  26. pmc A standard procedure for creating a frailty index
    Samuel D Searle
    Geriatric Medicine Research Unit, Dalhousie University and Capital District Health Authority, Halifax, Canada
    BMC Geriatr 8:24. 2008
    ..A frailty index can be developed from most ageing databases. Our objective is to systematically describe a standard procedure for constructing a frailty index...
  27. ncbi A population-based study of the incidence and complication rates of herpes zoster before zoster vaccine introduction
    Barbara P Yawn
    Department of Research, Olmsted Medical Center, 210 Ninth St SE, Rochester, MN, USA
    Mayo Clin Proc 82:1341-9. 2007
    ..To establish accurate, up-to-date, baseline epidemiological data for herpes zoster (HZ) before the introduction of the recently licensed HZ vaccine...
  28. ncbi The prevalence of pain and pain interference in a general population of older adults: cross-sectional findings from the North Staffordshire Osteoarthritis Project (NorStOP)
    Elaine Thomas
    Primary Care Sciences Research Centre, Keele University, Keele, North Staffordshire, ST5 5BG, UK
    Pain 110:361-8. 2004
    ..More importantly the extent to which pain interferes with everyday life increases incrementally with age up to the oldest age-group in the community-dwelling general population...
  29. ncbi Trends of obesity and underweight in older children and adolescents in the United States, Brazil, China, and Russia
    Youfa Wang
    Carolina Population Center, School of Public Health, University of North Carolina, Chapel Hill 27516 3997, USA
    Am J Clin Nutr 75:971-7. 2002
    ..Few studies have used the same references across countries to examine the trends of over- and underweight in older children and adolescents...
  30. pmc DNA methylation profiling of human chromosomes 6, 20 and 22
    Florian Eckhardt
    Epigenomics AG, Kleine Präsidentstrasse 1, 10178 Berlin, Germany
    Nat Genet 38:1378-85. 2006
    ..Our data suggest DNA methylation to be ontogenetically more stable than previously thought...
  31. ncbi Neurodevelopmental trajectories of the human cerebral cortex
    Philip Shaw
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:3586-94. 2008
  32. ncbi Prevalence, co-morbidity and correlates of mental disorders in the general population: results from the German Health Interview and Examination Survey (GHS)
    F Jacobi
    Institute of Clinical Psychology and Psychotherapy, Unit Epidemiology and Service Research, Technical University of Dresden, Germany
    Psychol Med 34:597-611. 2004
    ..This paper reports results from its Mental Health Supplement (GHS-MHS) on 4-week 12-month, and selected lifetime prevalence of a broad range of DSM-IV mental disorders, their co-morbidity and correlates in the community...
  33. ncbi Prior juvenile diagnoses in adults with mental disorder: developmental follow-back of a prospective-longitudinal cohort
    Julia Kim-Cohen
    Institute of Psychiatry, King s College, London, England
    Arch Gen Psychiatry 60:709-17. 2003
    ..If most adults with mental disorders are found to have a juvenile psychiatric history, this would shift etiologic research and prevention policy to focus more on childhood mental disorders...
  34. ncbi Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells
    Karin Stenderup
    University Department of Endocrinology and Metabolism, University Hospital of Aarhus, DK 8000 Aarhus C, Denmark
    Bone 33:919-26. 2003
    ..In conclusion, aging is associated with decreased proliferative capacity of osteoprogenitor cells, suggesting that decreased osteoblastic cell number, and not function, leads to age-related decrease in bone formation...
  35. ncbi Validity of body mass index compared with other body-composition screening indexes for the assessment of body fatness in children and adolescents
    Zuguo Mei
    Division of Nutrition and Physical Activity, Centers for Disease Control and Prevention, Atlanta, GA 30341 3724, USA
    Am J Clin Nutr 75:978-85. 2002
    ..Validation studies of height- and weight-based indexes of body fatness in children and adolescents have examined only small samples of school-age children...
  36. pmc Short sleep duration and weight gain: a systematic review
    Sanjay R Patel
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH, USA
    Obesity (Silver Spring) 16:643-53. 2008
    ..This work reviews the literature regarding short sleep duration as an independent risk factor for obesity and weight gain...
  37. ncbi Heat stress and public health: a critical review
    R Sari Kovats
    Public and Environmental Health Research Unit PEHRU, London School of Hygiene and Tropical Medicine, London, UK
    Annu Rev Public Health 29:41-55. 2008
  38. ncbi Health-related quality of life in total hip and total knee arthroplasty. A qualitative and systematic review of the literature
    Olivier Ethgen
    WHO Collaborating Center for Public Health Aspects of Osteoarticular Diseases, Department of Public Health, Epidemiology, and Health Economics, University of Liege, Belgium, Liege, Belgium
    J Bone Joint Surg Am 86:963-74. 2004
    ..The objective of this study was to review the literature regarding the outcomes of total hip and knee arthroplasties as evaluated by health-related quality-of-life instruments...
  39. pmc The association between glucometabolic disturbances, traditional cardiovascular risk factors and self-rated health by age and gender: a cross-sectional analysis within the Malmö Preventive Project
    Margret Leosdottir
    Department of Cardiology, Skane University Hospital, and Heart Health Group Department of Clinical Sciences, Lund University, Malmo, Sweden
    Cardiovasc Diabetol 10:118. 2011
    ..Whether this age-related reduction applies to CVD risk factors, and whether it is limited to established diabetes mellitus (DM) or also applies to pre-diabetic conditions are not well known...
  40. pmc Cardiometabolic risk variables in overweight and obese children: a worldwide comparison
    Mariska van Vliet
    Department of Pediatrics, Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands
    Cardiovasc Diabetol 10:106. 2011
    ..The results of our review present a fair estimation of the true differences between cardiometabolic risk profiles among pediatric cohorts worldwide, based on available literature...
  41. ncbi Sexual behaviour in context: a global perspective
    Kaye Wellings
    London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Lancet 368:1706-28. 2006
  42. ncbi Regional brain changes in aging healthy adults: general trends, individual differences and modifiers
    Naftali Raz
    Department of Psychology and Institute of Gerontology, Wayne State University, 87 East Ferry St, 226 Knapp Building, Detroit, MI 48202, USA
    Cereb Cortex 15:1676-89. 2005
    ..No sex differences in age trends except for the caudate were observed. We found no evidence of neuroprotective effects of larger brain size or educational attainment...
  43. pmc Immunoglobulin G subclass-specific responses against Plasmodium falciparum merozoite antigens are associated with control of parasitemia and protection from symptomatic illness
    Danielle I Stanisic
    Infection and Immunity Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Australia
    Infect Immun 77:1165-74. 2009
    ..However, no antibody response was significantly associated with protection from parasitization per se. Our findings have major implications for understanding human immunity and for malaria vaccine development and evaluation...
  44. pmc The challenge of comprehensively mapping children's health in a nation-wide health survey: design of the German KiGGS-Study
    Bärbel Maria Kurth
    Department of Epidemiology and Health Reporting, Robert Koch Institute, Seestrasse 10, 13353 Berlin, Germany
    BMC Public Health 8:196. 2008
    ..Aim of this first nationwide interview and examination survey was to collect comprehensive data on the health status of children and adolescents aged 0 to 17 years...
  45. ncbi Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease
    Miia Kivipelto
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Arch Neurol 62:1556-60. 2005
    ..Vascular risk factors play a role in the development of dementia, including Alzheimer disease (AD). However, little is known about the effect of body mass index and clustering of vascular risk factors on the development of dementia...
  46. pmc Adding social deprivation and family history to cardiovascular risk assessment: the ASSIGN score from the Scottish Heart Health Extended Cohort (SHHEC)
    Mark Woodward
    Cardiovascular Epidemiology Unit, Institute of Cardiovascular Research, University of Dundee, Ninewells Hospital, Dundee, Scotland, UK
    Heart 93:172-6. 2007
    ..To improve equity in cardiovascular disease prevention by developing a cardiovascular risk score including social deprivation and family history...
  47. ncbi When is baseline adjustment useful in analyses of change? An example with education and cognitive change
    M Maria Glymour
    Department of Society, Human Development, and Health, Harvard School of Public Health, Boston, MA 02215, USA
    Am J Epidemiol 162:267-78. 2005
    ..In some cases, change-score analyses without baseline adjustment provide unbiased causal effect estimates when baseline-adjusted estimates are biased...
  48. ncbi What does epidemiology tell us about risk factors for herpes zoster?
    Sara L Thomas
    Infectious Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Lancet Infect Dis 4:26-33. 2004
    ..We suggest areas of research that could lead to interventions to limit the incidence of zoster. Such research might also help to identify risk factors for age-related immune decline...
  49. ncbi High temperature and hospitalizations for cardiovascular and respiratory causes in 12 European cities
    Paola Michelozzi
    Department of Epidemiology Local Health Authority Rome E, Rome, Italy
    Am J Respir Crit Care Med 179:383-9. 2009
    ..Episode analyses of heat waves have documented a comparatively higher impact on mortality than on morbidity (hospital admissions) in European cities. The evidence from daily time series studies is scarce and inconsistent...
  50. pmc Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria
    P C Bull
    Kenya Medical Research Institute CRC, Kilifi Unit
    Nat Med 4:358-60. 1998
    ..The apparent selective pressure exerted by established anti-PfEMP1 antibodies on infecting parasites supports the idea that such responses provide variant-specific protection against disease...
  51. pmc Antiretroviral therapy adherence, virologic and immunologic outcomes in adolescents compared with adults in southern Africa
    Jean B Nachega
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 51:65-71. 2009
    ..To determine adherence to and effectiveness of antiretroviral therapy (ART) in adolescents vs. adults in southern Africa...
  52. ncbi Future of cancer incidence in the United States: burdens upon an aging, changing nation
    Benjamin D Smith
    Radiation Oncology Flight, Wilford Hall Medical Center, Lackland Air Force Base, 2200 Bergquist Dr, Ste 1, TX 78236, USA
    J Clin Oncol 27:2758-65. 2009
    ..We sought to estimate the number of cancer patients diagnosed in the United States through 2030 by age and race...
  53. ncbi Risk factors for depression among elderly community subjects: a systematic review and meta-analysis
    Martin G Cole
    Department of Psychiatry, St Mary s Hospital and McGill University, Quebeck, Canada
    Am J Psychiatry 160:1147-56. 2003
    ..The goal of this study was to determine risk factors for depression among elderly community subjects...
  54. ncbi NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older
    Charles M Alexander
    Outcomes Research and Management, U S Medical and Scientific Affairs, Merck and Co, Inc, West Point, PA, USA
    Diabetes 52:1210-4. 2003
    ..However, individuals with diabetes without metabolic syndrome had no greater prevalence of CHD compared with those with neither...
  55. ncbi How many steps/day are enough? Preliminary pedometer indices for public health
    Catrine Tudor-Locke
    Department of Exercise and Wellness, Arizona State University, Mesa, Arizona 85212, USA
    Sports Med 34:1-8. 2004
    ..or=10000 steps/day indicates the point that should be used to classify individuals as 'active'. Individuals who take >12500 steps/day are likely to be classified as 'highly active'...
  56. pmc Human CD4+ T cell recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function
    Christopher J Haines
    Department of Pediatrics and the Immunology Program, Stanford University, Stanford, CA 94305, USA
    J Exp Med 206:275-85. 2009
    ..The ability to identify viable CD4(+) RTEs by PTK7 staining should be useful for monitoring thymic output in both healthy individuals and in patients with genetic or acquired CD4(+) T cell immunodeficiencies...
  57. pmc A large-scale candidate gene association study of age at menarche and age at natural menopause
    Chunyan He
    Department of Public Health, Indiana University School of Medicine, Indianapolis, IN, USA
    Hum Genet 128:515-27. 2010
    ..013), and the group of genes involved in premature ovarian failure with age at menopause (P = 0.025)...
  58. ncbi The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration
    Anne Simone Parent
    Division of Ambulatory Pediatrics and Adolescent Medicine, University of Liege, B 4000 Liege, Belgium
    Endocr Rev 24:668-93. 2003
  59. pmc The discordance between clinical and radiographic knee osteoarthritis: a systematic search and summary of the literature
    John Bedson
    Arthritis Research Campaign National Primary Care Centre, Keele University, Staffordshire, ST5 5BG, United Kingdom
    BMC Musculoskelet Disord 9:116. 2008
  60. ncbi Excess mortality following hip fracture: a systematic epidemiological review
    B Abrahamsen
    Department of Internal Medicine and Endocrinology, Copenhagen University Hospital Gentofte, Niels Andersensvej 65, 2900, Hellerup, Denmark
    Osteoporos Int 20:1633-50. 2009
  61. pmc Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics
    Tamara B Harris
    Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD 20892 9205, USA
    Am J Epidemiol 165:1076-87. 2007
    ..This approach should facilitate identification of genetic factors that contribute to healthy aging as well as the chronic conditions common in old age...
  62. ncbi Influences of age and gender on results of noninvasive brachial-ankle pulse wave velocity measurement--a survey of 12517 subjects
    Hirofumi Tomiyama
    The Second Department of Internal Medicine, Tokyo Medical University, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Atherosclerosis 166:303-9. 2003
    ..Thus, aging influences baPWV, and its effect is more prominent in female. Menopause seems to be the crucial phenomenon to explain the augmented increase in arterial stiffness with aging in females...
  63. ncbi Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease
    Elizabeth J Slow
    Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4
    Hum Mol Genet 12:1555-67. 2003
  64. ncbi Safety, immunogenicity, and efficacy of quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine in women aged 24-45 years: a randomised, double-blind trial
    Nubia Munoz
    National Institute of Cancer, Bogota, Colombia
    Lancet 373:1949-57. 2009
    ..We tested the safety, immunogenicity, and efficacy of the quadrivalent HPV (types 6, 11, 16, 18) L1 virus-like-particle vaccine in women aged 24-45 years...
  65. ncbi The global breast cancer burden: variations in epidemiology and survival
    Gabriel N Hortobagyi
    The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Clin Breast Cancer 6:391-401. 2005
    ..This will aid the development of tailored strategies to improve outcomes in general as well as the standard of care for underserved populations and reduce the burden of breast cancer worldwide...
  66. ncbi Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions
    Deborah S Hasin
    Mailman School of Public Health, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Arch Gen Psychiatry 64:830-42. 2007
    ..Epidemiologic information is important to inform etiological research and service delivery planning. However, current information on the epidemiology of alcohol use disorders in the United States is lacking...
  67. ncbi Increasing incidence of differentiated thyroid cancer in the United States, 1988-2005
    Amy Y Chen
    Emory University, Atlanta, GA, USA
    Cancer 115:3801-7. 2009
    ..The objective of the current study was to investigate the trends in increasing incidence of differentiated (papillary and follicular) thyroid cancer by size, age, race, and sex...
  68. ncbi Self-reported health status of the general adult U.S. population as assessed by the EQ-5D and Health Utilities Index
    Nan Luo
    QualityMetric Incorporated, Lincoln, RI, USA
    Med Care 43:1078-86. 2005
    ..This study aimed to describe the self-reported health status of the general adult U.S. population using 3 multi-attribute preference-based measures: the EQ-5D, Health Utilities Index Mark 2 (HUI2), and Mark 3 (HUI3)...
  69. ncbi Sex, age, cardiovascular risk factors, and coronary heart disease: a prospective follow-up study of 14 786 middle-aged men and women in Finland
    P Jousilahti
    National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
    Circulation 99:1165-72. 1999
    ..In both sexes, CHD risk increases with age, but the increase is sharper in women. We analyzed the extent to which major cardiovascular risk factors can explain the sex difference and the age-related increase in CHD risk...
  70. ncbi Sleep duration from infancy to adolescence: reference values and generational trends
    Ivo Iglowstein
    Growth and Development Center, University Children s Hospital, Zurich, Switzerland
    Pediatrics 111:302-7. 2003
  71. ncbi Longitudinal magnetic resonance imaging studies of older adults: a shrinking brain
    Susan M Resnick
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, Maryland 21224 6825, USA
    J Neurosci 23:3295-301. 2003
  72. ncbi Moderate-to-vigorous physical activity from ages 9 to 15 years
    Philip R Nader
    Department of Pediatrics, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0927, USA
    JAMA 300:295-305. 2008
    ..Although at least 60 minutes per day of moderate-to-vigorous physical activity (MVPA) is recommended, few longitudinal studies have determined the recent patterns of physical activity of youth...
  73. ncbi Magnetic resonance imaging and head circumference study of brain size in autism: birth through age 2 years
    Heather Cody Hazlett
    Neurodevelopmental Disorders Research Center, University of North Carolina, Campus Box 3367, Chapel Hill, NC 27599, USA
    Arch Gen Psychiatry 62:1366-76. 2005
    ..Inferences about the timing of brain enlargement have recently come from studies of head circumference (HC)...
  74. pmc Age-associated DNA methylation in pediatric populations
    Reid S Alisch
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Genome Res 22:623-32. 2012
  75. ncbi Advanced maternal age--how old is too old?
    Linda J Heffner
    Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, USA
    N Engl J Med 351:1927-9. 2004
  76. ncbi Determinants of HIV prevalence among female sex workers in four south Indian states: analysis of cross-sectional surveys in twenty-three districts
    Banadakoppa M Ramesh
    Department of Community Health Sciences, University of Manitoba, Winnipeg, Canada
    AIDS 22:S35-44. 2008
    ..In four states in southern India we explored the determinants of HIV prevalence among female sex workers (FSW), as well as factors associated with district-level variations in HIV prevalence among FSW...
  77. pmc If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice
    Vladimir N Anisimov
    N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg, Russia
    Aging (Albany NY) 3:148-57. 2011
    ..Thus, in female SHR mice, metformin increased life span and postponed tumors when started at the young and middle but not at the old age. In contrast, metformin improves reproductive function when started at any age...
  78. ncbi Who infects whom? HIV-1 concordance and discordance among migrant and non-migrant couples in South Africa
    Mark N Lurie
    South African Medical Research Council, HIV Prevention and Vaccine Research Unit, Durban, South Africa
    AIDS 17:2245-52. 2003
    ..To measure HIV-1 discordance among migrant and non-migrant men and their rural partners, and to estimate the relative risk of infection from inside versus outside primary relationships...
  79. ncbi The impact of childhood intelligence on later life: following up the Scottish mental surveys of 1932 and 1947
    Ian J Deary
    Department of Psychology, University of Edinburgh, Edinburgh, Scotland
    J Pers Soc Psychol 86:130-47. 2004
  80. ncbi Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum
    Mikio Hoshino
    Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Neuron 47:201-13. 2005
    ..Our results suggest that Ptf1a is involved in driving neural precursors to differentiate into GABAergic neurons in the cerebellum...
  81. ncbi Age-dependent decline of symptoms of attention deficit hyperactivity disorder: impact of remission definition and symptom type
    J Biederman
    Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 157:816-8. 2000
    ..Symptom decline in attention deficit hyperactivity disorder (ADHD) was examined with different definitions of remission...
  82. ncbi Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California cancer Registry
    Katrina R Bauer
    Public Health Institute California Cancer Registry, Sacramento, California 95815 4402, USA
    Cancer 109:1721-8. 2007
    ..The triple-negative phenotype is important because of its relation to the basal-like subtype of breast cancer...
  83. ncbi Prevalence, correlates, disability, and comorbidity of DSM-IV drug abuse and dependence in the United States: results from the national epidemiologic survey on alcohol and related conditions
    Wilson M Compton
    Division of Epidemiology, Services, and Prevention Research, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 9304, USA
    Arch Gen Psychiatry 64:566-76. 2007
    ..Current and comprehensive information on the epidemiology of DSM-IV 12-month and lifetime drug use disorders in the United States has not been available...
  84. ncbi Obesity, regional body fat distribution, and the metabolic syndrome in older men and women
    Bret H Goodpaster
    Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Arch Intern Med 165:777-83. 2005
    ..We determined whether patterns of regional fat deposition are associated with metabolic syndrome in older adults...
  85. ncbi Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research
    M Robin Dimatteo
    Department of Psychology, University of California, Riverside, CA 92521, USA
    Med Care 42:200-9. 2004
    ..The literature on patient adherence to treatment includes hundreds of empirical studies. A comprehensive examination of the findings requires the organization and quantification that is possible with meta-analysis...
  86. ncbi Anemia is associated with disability and decreased physical performance and muscle strength in the elderly
    Brenda W J H Penninx
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 52:719-24. 2004
    ..To examine the association between anemia and disability, physical performance, and muscle strength in older persons...
  87. pmc Statistical methods for the time-to-event analysis of individual participant data from multiple epidemiological studies
    Simon Thompson
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Int J Epidemiol 39:1345-59. 2010
    ..Meta-analysis of individual participant time-to-event data from multiple prospective epidemiological studies enables detailed investigation of exposure-risk relationships, but involves a number of analytical challenges...
  88. ncbi Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo
    Vladimir N Anisimov
    N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Cell Cycle 9:188-97. 2010
    ..001). The combined treatment with metformin + melatonin significantly suppressed Ehrlich tumor growth (by 40%, p < 0.001). These results suggest that metformin may be useful in prevention and treatment of breast cancer...
  89. pmc The relationship between serum uric acid level and metabolic syndrome: differences by sex and age in Taiwanese
    Wen Ko Chiou
    Department of Industrial Design, Chang Gung University, Kweishan, Taoyuan, Taiwan, ROC
    J Epidemiol 20:219-24. 2010
    ..This study was performed to explore the potential value of UA level as a marker of MetS among male and female Chinese of different ages...
  90. pmc Survival of HIV-infected adolescents on antiretroviral therapy in Uganda: findings from a nationally representative cohort in Uganda
    Celestin Bakanda
    The AIDS Support Organization, Kampala, Uganda
    PLoS ONE 6:e19261. 2011
    ..Adolescents have been identified as a high-risk group for poor adherence to and defaulting from combination antiretroviral therapy (cART) care. However, data on outcomes for adolescents on cART in resource-limited settings remain scarce...
  91. pmc Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways
    Lisette Stolk
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Nat Genet 44:260-8. 2012
    ..Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-κB signaling and mitochondrial dysfunction as biological processes related to timing of menopause...
  92. pmc Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies
    Sanae Sasaki
    Department of Immunology and Microbiology, Stanford University School of Medicine, Stanford, California, USA
    J Clin Invest 121:3109-19. 2011
    ..They also suggest that exposure history affects the cross-reactivity of vaccination-induced antibodies...
  93. ncbi Can parents rate their child's health-related quality of life? Results of a systematic review
    C Eiser
    Department of Psychology, University of Sheffield, Western Bank, UK
    Qual Life Res 10:347-57. 2001
    ..All of these results may be dependent on the specific measure of HRQoL employed. There remain strong arguments for obtaining information from both parents and children whenever possible...
  94. ncbi Prediction of lifetime risk for cardiovascular disease by risk factor burden at 50 years of age
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Circulation 113:791-8. 2006
    ..Lifetime risk for atherosclerotic cardiovascular disease (CVD) has not previously been estimated, and the effect of risk factor burden on lifetime risk is unknown...
  95. pmc Plasmodium infection and its risk factors in eastern Uganda
    Rachel L Pullan
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 9:2. 2010
    ..This report presents results from a total population survey of malaria infection and intervention coverage in a rural area of eastern Uganda, with a specific focus on how risk factors differ between demographic groups in this population...
  96. pmc Self rated health: Is it as good a predictor of subsequent mortality among adults in lower as well as in higher social classes?
    B Burstrom
    Department of Public Health Sciences, Division of Social Medicine, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    J Epidemiol Community Health 55:836-40. 2001
    ..To analyse the predictive power of self rated health for mortality in different socioeconomic groups...
  97. pmc Household transmission of 2009 pandemic influenza A (H1N1) virus in the United States
    Simon Cauchemez
    Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London
    N Engl J Med 361:2619-27. 2009
    ..Risk factors for transmission remain largely uncharacterized. We characterize the risk factors and describe the transmission of the virus within households...
  98. pmc Immuno-epidemiologic correlates of pandemic H1N1 surveillance observations: higher antibody and lower cell-mediated immune responses with advanced age
    Danuta M Skowronski
    British Columbia Centre for Disease Control, Vancouver, BC, V5Z 4R4, Canada
    J Infect Dis 203:158-67. 2011
    ..Pandemic H1N1 (pH1N1) surveillance data showed lower attack rates but higher risk of severe outcomes with advanced age. We explored immuno-epidemiologic correlates of surveillance findings including humoral and cell-mediated immunity (CMI)...
  99. ncbi Mortality after osteoporotic fractures
    O Johnell
    Department of Orthopaedics, Malmo University Hospital, Malmo, Sweden
    Osteoporos Int 15:38-42. 2004
    ..The decreasing mortality with time after fracture may be due in part to a decrease in deaths causally related to the fracture. The extent to which early intervention for osteoporosis might avoid some of these deaths is unknown...
  100. ncbi Comparing rat's to human's age: how old is my rat in people years?
    Robert Quinn
    Nutrition 21:775-7. 2005
  101. ncbi Executive function and the frontal lobes: a meta-analytic review
    Julie A Alvarez
    Department of Psychology, Emory University, Atlanta, GA 30322, USA
    Neuropsychol Rev 16:17-42. 2006
    ..The paper concludes with a discussion of the implications of construing the validity of these neuropsychological tests in anatomical, rather than cognitive and behavioral, terms...

Research Grants98

    EDWARD TODD WEBER; Fiscal Year: 2010
    ..More generally, this research will investigate the potential relationships between hippocampal neurogenesis and both processes of learning and memory and in the development of anxiety or depression-related behaviors. ..
  2. Co-infection of mice with MHV68 and rodent Plasmodium species
    Samuel H Speck; Fiscal Year: 2013
    ..3. Examine impact of anti-malarial and anti-viral treatment on disease severity;and Aim 2.4. Assess long-term sequelae from co-infection under conditions that favor animal survival. ..
  3. Age factors, mutations, and chemical suppressors of acute myelogenous leukemia
    JING RUEY JOANNA YEH; Fiscal Year: 2012
    ..Ultimately, this program will facilitate the candidate's goals of becoming an independent investigator in cancer and aging. ..
    SAMUEL PRESTON; Fiscal Year: 2001
    ..A by-product of this latter method will be new estimates of census completeness. Cause-of-death life tables will also be produced for the African-American population during the 1980-1990 period. ..
    JAMES OKUNEWICK; Fiscal Year: 1993
    ..analyses of the clinical data have suggested that these disparities may involve donor/recipient sex-match, age factors, and, especially, previous allosensitization of the donor to minor histocompatibility antigens either through ..
  6. Knee OA: Setting Priorities for Care, Policy, Research
    Elena Losina; Fiscal Year: 2010
    ..This study will provide guidance to clinicians and policy makers on efforts to reduce pain and disability, and to improve quality of life for people with knee osteoarthritis. ..
  7. Modeling Sequential Antiretroviral Therapy in HIV
    Elena Losina; Fiscal Year: 2005
    ..This award will provide critical insight into the optimal strategies for managing HIV infection and will provide Dr. Losina with a solid foundation for development as an independent and productive investigator. ..
  8. Lymphoma in Autoimmune Disease: Consequence of Immune Suppression or Stimulation?
    Sasha Bernatsky; Fiscal Year: 2008
    ..Our proposed project will help identify patients at highest risk for lymphoma and provide guidance regarding initiation and maintenance of therapy to control SLE. [unreadable] [unreadable] [unreadable]..
  9. Determinants and Consequences of Alcohol Consumption
    Frank Sloan; Fiscal Year: 2008
    ..abstract_text> ..
  10. Visual Impairment, Treatment and Effects on the Elderly
    Frank Sloan; Fiscal Year: 2008
    ..Ten papers are anticipated for this four-year study. [unreadable] [unreadable]..
  11. Risk of Adverse Outcomes after Spinal Cord Injury: A Longitudinal Study
    James S Krause; Fiscal Year: 2010
    ..abstract_text> ..
  12. Effects of the Minimum Drinking Age on Mortality, Nonfatal Injury, and Crime
    Christopher Carpenter; Fiscal Year: 2009
    ..In so doing, this project will have the potential to reduce alcohol related harms experienced by youths. ..
    James Krause; Fiscal Year: 2002
    ..Risk profiles will be generated to identify individuals at greatest risk for early mortality. Separate analyses and risk profiles will be generated based on injury severity, gender and race/ethnicity. ..
    Frank Sloan; Fiscal Year: 2001
    ..We will examine implications of our empirical analysis for tort claims brought against tobacco companies and the evolution of legal theories underlying tobacco tort litigation in a law review article. ..
  15. Collaborative Pediatric Bipolar Disorder Conference
    Joseph Biederman; Fiscal Year: 2007
    ..While the proposed conference does not intend to solve all outstanding problems associated with pediatric bipolar disorder, it will provide a forum to begin formulating a solution. ..
    ROBERTO TREVINO; Fiscal Year: 2004
    ..Biological outcomes will fasting capillary glucose levels. Ultimately, we would like to delay or prevent the onset of type 2 diabetes. ..
  17. Effects of Aging on Executive Processes
    Timothy Salthouse; Fiscal Year: 2006
    ..e., specific to individual variables or common to many variables) at which age-related influences operate on executive process variables. ..
  18. The Balanced Budget Act of 1997 and Home Care for Cancer
    Meredith Kilgore; Fiscal Year: 2006
    ..Data generated from this study can be used to guide federal decision makers in formulating policies related to home health services for older cancer patients. ..
  19. Iron Deficiency and Anemia in HIV and HCV-Infected Women
    Richard Semba; Fiscal Year: 2005
    ..S. and elsewhere. ..
  20. Regulation of immunoglobulin class switch in senescent humans
    Bonnie Blomberg; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  21. Adolescent Gastric By-Pass and Diabetic Precursors
    Thomas Inge; Fiscal Year: 2006
    Lynn Rosenberg; Fiscal Year: 2007
    ..CCS results have repeatedly been confirmed in other studies, indicating the success of efforts to minimize bias. CCS is a unique resource for cancer epidemiology. ..
  23. Support of the Caregiver of the Older Cancer Patient Undergoing Chemotherapy
    Lodovico Balducci; Fiscal Year: 2008
    ..This study provides an opportunity to address problems associatedwith intense short-term caregiving in this expanding population. ..
  24. The impact of early antiretroviral therapy on HIV persistence and inflammation
    STEVEN GRANT DEEKS; Fiscal Year: 2010
    ..Our work may also provide important insights in the role of chronic inflammation in driving viral persistence, and hence may lead to the development of novel interventions. ..
  25. Prospective evaluation of IGF and IL-6 Dysregulation and Multiple Myeloma
    Graham A Colditz; Fiscal Year: 2010
    ..The team is led from by Drs. Colditz and Anderson and is supported by a senior statistician (Dr. Rosner) and a study director (Dr. Birmann) who is funded, in part, through a K award. ..
  26. Translational Research in the Dystrophinopathies
    Kevin M Flanigan; Fiscal Year: 2010
    ..Although we do not propose to perform treatment trials at present, this proposed study will identify cohorts of patients who may be candidates for any future trials here or at other institutions. ..
  27. Genetic Polymorphisms Benign Prostatic Hyperplasia
    ROSEBUD ROBERTS; Fiscal Year: 2004
    ..This community-based cohort study should provide insights that should improve our understanding of the genetic control of hormonal mechanisms in the pathogenesis of BPH. ..
  28. Feasibility and Pilot Efficacy of Flash-heated Breastmilk to Reduce Pediatric HIV
    Caroline Chantry; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. Plasma protein synthesis and abundance in T1 diabetes
    K Sreekumaran Nair; Fiscal Year: 2008
    ..These studies are anticipated to form the basis of more elaborate mechanistic studies in the future and hopefully will lead to alternative therapeutic approaches for T1 D. ..
  30. Vascular and Inflammatory Predictors of MCI Risk and Progression
    ROSEBUD ROBERTS; Fiscal Year: 2008
    ..The K01 award will culminate in an R01 application that will pave the way for the candidate to become an independent investigator in MCI and AD research. [unreadable] [unreadable] [unreadable]..
  31. Course of psychopathology in female youth: Analysis with extant longitudinal data
    Joseph Biederman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  32. Immunologic Control of Drug-resistant HIV-1
    Steven Deeks; Fiscal Year: 2005
    ..Finally, since we will estimate the relative in vivo thresholds for HIV-mediated immunogenicity and pathogenicity, these studies may also have implications for vaccine development. ..
  33. Drug use and health disparities in 2 Indian populations
    Janette Beals; Fiscal Year: 2003
  34. Treatment Utilization for Alcohol-Related Problems
    Li Tzy Wu; Fiscal Year: 2002
    Nancy Lane; Fiscal Year: 2002
    Barbara Mensch; Fiscal Year: 2001
    Richard Semba; Fiscal Year: 2001
    ..The relationship between mastitis and breastmilk HIV load and the epidemiology and microbiology of mastitis will be examined in a new cohort of HIV-infected lactating women. ..
    Bonnie Blomberg; Fiscal Year: 2005
    ..The experiments in this proposal will provide a molecular dissection of the abnormal regulation lambda5/VpreB which we hypothesize results in decreased pre-B-cells and an altered VH repertoire in aged mice. ..
  39. Alcohol modulates TLR2 signaling in airway epithelium
    KRISTINA BAILEY; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  40. Trial of Infant Probiotic Exposure on Developing Asthma
    Michael Cabana; Fiscal Year: 2008
    ..We expect that when compared to controls, subjects receiving Lactobacillus will have decreased and delayed development of markers for asthma, and a greater likelihood of developing a Th1 phenotype. [unreadable] [unreadable]..
    Eleftherios Diamandis; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  42. Cigarette smoking and colorectal cancer risk
    Andrew Hyland; Fiscal Year: 2003
    ..abstract_text> ..
  43. Association of Thrombophilia and Inflammation with Post-Thrombotic Syndrome
    Mary Cushman; Fiscal Year: 2008
    ..Resultant disability is estimated at 2 million lost workdays/year and medical costs as $300 million yearly. Findings here can form the basis for development of new therapies to treat, and moreover prevent,PTS. ..
  44. Regulation of E2A in Normal and Aged B Lymphopoiesis
    Richard Riley; Fiscal Year: 2008
    ..More broadly, these studies will further our understanding of the immune defects which accompany old age and their cellular and molecular mechanisms. ..
  45. Human Kallikrein 4 (hK4): A New Prostatic Biomarker?
    Eleftherios Diamandis; Fiscal Year: 2003
    ..If successful, our research will contribute to the development of new prostatic biomarkers and possibly, to better diagnosis which may lead to better clinical outcomes and reduced healthcare costs. ..
    M Shear; Fiscal Year: 2003
    ..These sites already have in place the trained and certified assessment and treatment personnel and rigorous monitoring procedures that are essential for the conduct of a study such as the one we propose. ..
    James Sowers; Fiscal Year: 2003
    ..Thus, the proposed investigation will explore the role of PI3-kinase in mediating the cardiovascular interactions of AngII/IGF-1 after both short-term in vitro Ang II exposure and longer-term in vivo Ang II tissue excess. ..
    Joseph Biederman; Fiscal Year: 2002
  49. Improving Mortality Projections By Incorporating Cohort Smoking Histories
    SAMUEL PRESTON; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  50. Hospital strategies to improve outcome performance
    ELIZABETH HOWE BRADLEY; Fiscal Year: 2010
    ..We will work on dissemination strategies with CMS, JCAHO, American College of Cardiology (ACC), American Health Association (AHA), the Veteran's Administration (VA), and the VHA. ..
  51. The Natural History of Venous Thromboembolism in the Elderly
    Frederick A Spencer; Fiscal Year: 2010
    ..We will also examine how elderly patients with venous thromboembolism are currently being treated, whether some patients are at risk for inappropriate or under treatment, and the relationship of treatment to future complications. ..
    Barbara Klein; Fiscal Year: 2002
    Irma Elo; Fiscal Year: 2002
    ..The sample composition will permit us to address explicitly the role of race in infant health, and to examine whether factors contributing to infant health are similar for low income women in all racial/ethnic groups. ..
    PATTY LEE; Fiscal Year: 2002
    ..3) Determine the functional role of HO-1 after hyperoxia in vitro following hyperoxia. 4) Determine the functional role of HO-1 after hyperoxia in vivo using HO- 1 transgenic and knock-out mice. ..
  55. Epdemiology of Non-Medical Prescription Anagesic Use
    Li Tzy Wu; Fiscal Year: 2009
    ..Such findings will be vital to policy makers in predicting the potential burden of NMPAU-related problems. ..
  56. US Prostate Cancer Detection with Dutasteride Pretreatment
    Ethan Halpern; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  57. The Development of Visual Integration & Attention: A High-Density EEG Study
    Melanie Palomares; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
    ..The aim will include validating the model by correlating changes in levels of tPA activity with the disease progression, and manipulating tPA activity levels to determine if the disease progression can be altered. ..
  59. Adult Outcome of Attention Deficit Hyperactivity Disorder
    Joseph Biederman; Fiscal Year: 2007
    ..For these reasons, we expect the proposed work to clarify the course and outcome of ADHD. ..
    Richard Semba; Fiscal Year: 2005
    Lynn Rosenberg; Fiscal Year: 2005
    ..Millions of women worldwide have used IPCs. Given the heavy burden of osteoporotic fractures in elderly women, it is of public health importance to determine whether IPCs have an adverse effect on bone. ..
  62. Work injury and young people: A prospective survey
    F Breslin; Fiscal Year: 2005
    ..No study to date has examined the impact of work injuries on earnings losses among young workers, thereby addressing a notable gap in this research area. ..
  63. Mechanical Intervention in Children with Cerebral Palsy
    Tishya Wren; Fiscal Year: 2005
    ..This study will also provide insight into the potential role of muscle adaptation and bone turnover in increasing bone mass in response to this simple, non-invasive, non-pharmacalogical intervention. ..
  64. Linkage Studies of Quantitative Ocular Traits
    Barbara Klein; Fiscal Year: 2006
    ..Subsequent follow-up with fine mapping of areas of interest in the genome is planned. ..
  65. Chronic stressors and drug abuse in 2 Indian populations
    Janette Beals; Fiscal Year: 2006
    ..The proposed work promises to provide the most comprehensive and focused investigation to date of chronic stressors within Al populations and of the relationship of various stressors with drug use and disorder. ..
    Janette Beals; Fiscal Year: 2004
    ..abstract_text> ..
  67. GHB: Effects, Withdrawal and Treatment
    Karen Miotto; Fiscal Year: 2006
    ..There has been little systematic study of the signs and symptoms of withdrawal, and controlled studies on the effectiveness of treatment of these symptoms are lacking. ..
  68. Understanding Parent Retention in Indicated Prevention
    CAROLE HOOVEN; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  69. Inhalant Use/Dependence: Incidence and Comorbidity
    Li Tzy Wu; Fiscal Year: 2005
    ..Gaps in our knowledge of the natural course of inhalant use will be specified for future research. ..
    Richard Semba; Fiscal Year: 2002
  71. A New Biomarker for Ovarian Cancer Detection
    Eleftherios Diamandis; Fiscal Year: 2003
    ..In this grant proposal, we describe further studies, which will examine in greater detail, the ability of a test for the amount of this protein in blood to correctly diagnose the presence of ovarian cancer. ..
  72. Pregnancy Outcomes in Polycystic Ovary Syndrome
    Joan Lo; Fiscal Year: 2009
  73. Multivariate Analysis of the Total Fertility Rate and Its Components
    Robert D Retherford; Fiscal Year: 2010
    ..The new methodology involves major extensions of methodology developed during an earlier R03 grant ("Components of Nuptiality and Fertility Change," 5R03HD45508-2, PI: Retherford) that expired November 30, 2007. ..
  74. Under the Skin: Understanding the Role of Stress and Immune Function in Health Di
    JENNIFER DOWD; Fiscal Year: 2009
    ..We will test whether these immune and infection markers are related to psychosocial and economic stressors and whether they mediate the relationship between SES and health outcomes including mortality. ..
    Elizabeth Karlson; Fiscal Year: 2002
    ..RA will be confirmed by a screening questionnaire regarding rheumatic symptoms and review of medical records. The study will identify potentially modifiable risk factors for primary prevention of RA. ..
  76. Sex Hormones, Related Polymorphisms & Cognitive Decline
    Kristine Yaffe; Fiscal Year: 2006
    ..Further knowledge of the association between sex hormones, hormone-related polymorphisms and cognitive decline may facilitate preventative strategies to maintain independence and to promote optimum brain aging. ..
  77. Conditioning-specific reflex modification
    BERNARD SCHREURS; Fiscal Year: 2004
    ..abstract_text> ..
  78. Sex Steroids & Mammographic Density in the Postmenopause
    Gail Greendale; Fiscal Year: 2007
    ..We will quantify the relations between the hormone and genetic exposures measured in this project and mammographic density (at baseline as well as change in density between baseline and 12 months). ..
  79. Specificity/Sensitivity in Mammographic Screening
    Daniel Kopans; Fiscal Year: 2006
    ..Tomosynthesis may result in improved detection, characterization and visualization of breast lesions which may ultimately reduce mortality from breast cancer, while dramatically reducing callback imaging studies. ..
  80. Neurobiologic Study of Psychological Distress & Dementia
    Robert S Wilson; Fiscal Year: 2010
  81. Oral Health/OHRQOL among low-SES rural adults
    GREGG GILBERT; Fiscal Year: 2004
    Mulchand Patel; Fiscal Year: 2002
    ..abstract_text> ..
  83. The Brain & Psychosis: Asymmetry & cortical organization
    Martin Reite; Fiscal Year: 2005
    ..Altered tototopy and somatotopy will be examined as antecedents or results of psychosis. The findings will help identify individuals at risk for illness, and separate disease and psychosis-associated brain changes in mental disorders. ..
  84. UW Stipends for Training Aspiring Researchers (STAR)
    Michael Portman; Fiscal Year: 2008
    ..increasing the numbers of underrepresented minority investigators involved in heart, lung, blood, and sleep disorder research. ..
  85. Triostat in Children During CPB
    Michael Portman; Fiscal Year: 2007
  86. FcR Mutations in Kawasaki Disease
    Michael Portman; Fiscal Year: 2008
    Robert Levine; Fiscal Year: 2002
    ..These studies may will reveal novel apoptotic regulatory mechanisms and provide new avenues for therapeutic approaches to promote neuronal survival and prevent debilitating neurological diseases, such as Parkinson's disease. ..
    GREGG GILBERT; Fiscal Year: 2003
    William Armstead; Fiscal Year: 2005
    ..These studies may lead to therapies for brain injured children. ..
  90. Auditory Perception of Drug Names: Neighborhood Effects
    Bruce Lambert; Fiscal Year: 2006
    ..abstract_text> ..
  91. The Fertility Transition in Brazil: 1960-2000
    JOSEPH POTTER; Fiscal Year: 2004
    ..abstract_text> ..
  92. OU Developmental Center for Injury Prevention Research
    Gary Raskob; Fiscal Year: 2005
    ..abstract_text> ..
  93. Oral Contraceptive Use along the US-Mexico Border
    JOSEPH POTTER; Fiscal Year: 2009
    ..Additionally, it will add substantially to the slim literature on the increasingly important area of Hispanic fertility and contraceptive practice. ..
    Anne Newman; Fiscal Year: 2007
    ..Accomplishing these goals will provide important information concerning the public health impact of SDB. [unreadable] [unreadable]..
    Yi Chung Pai; Fiscal Year: 2007
    ..Aim 3: We will determine whether older adults decrease their fall incidence after repeated exposure to slips by improving gait stability and/or by enhancing their reactive responses. ..
  96. Metabolic Polymorphisms and Survival from Brain Tumors
    Melissa Bondy; Fiscal Year: 2004
    ..Thus, patients who can tolerate higher doses of chemotherapy can be treated more efficiently, suffering from less side effects and potentially may have a better outcome. ..
  97. Eighth Cooley's Anemia Symposium
    Elliott Vichinsky; Fiscal Year: 2005
    Thomas Shanley; Fiscal Year: 2002
    ..The information may identify a means to modulate pulmonary inflammation in patients and identify novel biologic effects of IL-10 on viral-mediated inflammatory responses. ..