patient selection

Summary

Summary: Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.

Top Publications

  1. ncbi Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy
    Sean R Tunis
    Office of Clinical Standards and Quality, Centers for Medicare and Medicaid Services, Baltimore, MD 21244, USA
    JAMA 290:1624-32. 2003
  2. ncbi Review of sampling hard-to-reach and hidden populations for HIV surveillance
    Robert Magnani
    Family Health International, Arlington, VA, USA
    AIDS 19:S67-72. 2005
  3. pmc Pragmatic controlled clinical trials in primary care: the struggle between external and internal validity
    Marshall Godwin
    Centre for Studies in Primary Care, Queen s University, Kingston K7L 5E9, Canada
    BMC Med Res Methodol 3:28. 2003
  4. doi Natalizumab treatment for multiple sclerosis: updated recommendations for patient selection and monitoring
    Ludwig Kappos
    University Hospital, Basel, Switzerland
    Lancet Neurol 10:745-58. 2011
  5. ncbi Central challenges facing the national clinical research enterprise
    Nancy S Sung
    Burroughs Wellcome Fund, PO Box 13901, 21 T W Alexander Dr, Research Triangle Park, NC 27709, USA
    JAMA 289:1278-87. 2003
  6. pmc Reaching young adult smokers through the internet: comparison of three recruitment mechanisms
    Danielle E Ramo
    Department of Psychiatry, University of California, 401 Parnassus Avenue, Box CPT 0984, San Francisco, CA 94143, USA
    Nicotine Tob Res 12:768-75. 2010
  7. ncbi Gene expression profiling predicts clinical outcome of breast cancer
    Laura J van 't Veer
    Division of Diagnostic Oncology, The Netherlands Cancer Institute, 121 Plesmanlaan, 1066 CX Amsterdam, The Netherlands
    Nature 415:530-6. 2002
  8. pmc Improving the reporting of pragmatic trials: an extension of the CONSORT statement
    Merrick Zwarenstein
    Health Services Sciences, Sunnybrook Hospital, Toronto, Ontario, Canada
    BMJ 337:a2390. 2008
  9. ncbi Reporting participation in epidemiologic studies: a survey of practice
    Lindsay M Morton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Am J Epidemiol 163:197-203. 2006
  10. ncbi Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks
    Stanley B Cohen
    Radiant Research, Dallas, Texas 75235, USA
    Arthritis Rheum 54:2793-806. 2006

Detail Information

Publications262 found, 100 shown here

  1. ncbi Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy
    Sean R Tunis
    Office of Clinical Standards and Quality, Centers for Medicare and Medicaid Services, Baltimore, MD 21244, USA
    JAMA 290:1624-32. 2003
    ..For these changes to occur, clinical and health policy decision makers will need to become more involved in all aspects of clinical research, including priority setting, infrastructure development, and funding...
  2. ncbi Review of sampling hard-to-reach and hidden populations for HIV surveillance
    Robert Magnani
    Family Health International, Arlington, VA, USA
    AIDS 19:S67-72. 2005
    ..However, as its applicability to HIV surveillance in resource-poor settings has yet to be established, further field trials are needed before a firm conclusion can be reached...
  3. pmc Pragmatic controlled clinical trials in primary care: the struggle between external and internal validity
    Marshall Godwin
    Centre for Studies in Primary Care, Queen s University, Kingston K7L 5E9, Canada
    BMC Med Res Methodol 3:28. 2003
    ..We describe the design of the trials and the steps taken to deal with the competing demands of external and internal validity...
  4. doi Natalizumab treatment for multiple sclerosis: updated recommendations for patient selection and monitoring
    Ludwig Kappos
    University Hospital, Basel, Switzerland
    Lancet Neurol 10:745-58. 2011
    ..recommendations on natalizumab for treatment of patients with RRMS, based on additional long-term follow-up of clinical studies and post-marketing observations, including appropriate patient selection and management recommendations.
  5. ncbi Central challenges facing the national clinical research enterprise
    Nancy S Sung
    Burroughs Wellcome Fund, PO Box 13901, 21 T W Alexander Dr, Research Triangle Park, NC 27709, USA
    JAMA 289:1278-87. 2003
    ....
  6. pmc Reaching young adult smokers through the internet: comparison of three recruitment mechanisms
    Danielle E Ramo
    Department of Psychiatry, University of California, 401 Parnassus Avenue, Box CPT 0984, San Francisco, CA 94143, USA
    Nicotine Tob Res 12:768-75. 2010
    ....
  7. ncbi Gene expression profiling predicts clinical outcome of breast cancer
    Laura J van 't Veer
    Division of Diagnostic Oncology, The Netherlands Cancer Institute, 121 Plesmanlaan, 1066 CX Amsterdam, The Netherlands
    Nature 415:530-6. 2002
    ..This gene expression profile will outperform all currently used clinical parameters in predicting disease outcome. Our findings provide a strategy to select patients who would benefit from adjuvant therapy...
  8. pmc Improving the reporting of pragmatic trials: an extension of the CONSORT statement
    Merrick Zwarenstein
    Health Services Sciences, Sunnybrook Hospital, Toronto, Ontario, Canada
    BMJ 337:a2390. 2008
    ..In the meantime we recommend that those who support, conduct, and report pragmatic trials should use this extension of the CONSORT statement to facilitate the use of trial results in decisions about health care...
  9. ncbi Reporting participation in epidemiologic studies: a survey of practice
    Lindsay M Morton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Am J Epidemiol 163:197-203. 2006
    ..The authors conclude that epidemiologists need to address declining participation and to report participation consistently, including for biologic specimen collection...
  10. ncbi Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks
    Stanley B Cohen
    Radiant Research, Dallas, Texas 75235, USA
    Arthritis Rheum 54:2793-806. 2006
    ....
  11. pmc Online advertising as a public health and recruitment tool: comparison of different media campaigns to increase demand for smoking cessation interventions
    Amanda L Graham
    The Schroeder Institute for Tobacco Research and Policy Studies, American Legacy Foundation, NW, Washington, DC 20036, USA
    J Med Internet Res 10:e50. 2008
    ..Online ads can be implemented in many forms, and surveys consistently show that consumers are receptive. Few studies have examined the potential of online advertising to recruit smokers to cessation treatments...
  12. ncbi Are you busy for the next 5 years? Recruitment in the Childhood Asthma Prevention Study (CAPS)
    Seema Mihrshahi
    Clinical Epidemiology Unit, The Children s Hospital, Westmead
    Respirology 7:147-51. 2002
    ..In the present paper, the methods used for recruitment into the Childhood Asthma Prevention Study are reported and the reasons why eligible subjects chose not to participate or withdrew from the trial are examined...
  13. pmc A review of reporting of participant recruitment and retention in RCTs in six major journals
    Merran Toerien
    Department of Sociology, The University of York, Heslington, York, YO10 4PS, UK
    Trials 10:52. 2009
    ..This paper aims: (i) to update and extend previous reviews evaluating reporting of participant recruitment and retention in RCTs; (ii) to quantify the level of participation throughout RCTs...
  14. pmc Recruitment and retention strategies in longitudinal clinical studies with low-income populations
    Lisa M Nicholson
    School of Public Health, University of Illinois Chicago, USA
    Contemp Clin Trials 32:353-62. 2011
    ..Conducting longitudinal research studies with low-income and/or minority participants present a unique set of challenges and opportunities...
  15. ncbi Pediatricians' attitudes toward randomized controlled trials involving children
    Patrina H Y Caldwell
    Centre for Kidney Research, The Children s Hospital at Westmead, Sydney, Australia
    J Pediatr 141:798-803. 2002
    ..To examine pediatricians' attitudes toward children's participation in randomized controlled trials (RCTs) and identify possible barriers to participation...
  16. ncbi Randomized head-to-head comparison of pitavastatin, atorvastatin, and rosuvastatin for safety and efficacy (quantity and quality of LDL): the PATROL trial
    Keijiro Saku
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan
    Circ J 75:1493-505. 2011
    ..This is the first prospective randomized multi-center trial to compare these strong statins (UMIN Registration No: 000000586)...
  17. ncbi Strategies to improve recruitment to randomised controlled trials
    Shaun Treweek
    Division of Clinical and Population Sciences and Education, University of Dundee, Kirsty Semple Way, Dundee, UK, DD2 4BF
    Cochrane Database Syst Rev 4:MR000013. 2010
    ..Some strategies (e.g. open trial designs) need to be considered carefully before use because they also have disadvantages. For example, opt-out procedures are controversial and open designs are by definition unblinded...
  18. pmc Recruiting vulnerable populations into research: a systematic review of recruitment interventions
    Stacy J UyBico
    Section of General Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    J Gen Intern Med 22:852-63. 2007
    ..Members of vulnerable populations are underrepresented in research studies...
  19. pmc Formal representation of eligibility criteria: a literature review
    Chunhua Weng
    Department of Biomedical Informatics, Columbia University, New York, NY 10032, USA
    J Biomed Inform 43:451-67. 2010
    ..We discuss the implications of our findings for standardization efforts toward knowledge representation for sharable and computable eligibility criteria...
  20. ncbi Clinical trials in children
    Patrina H Y Caldwell
    Centre for Kidney Research, The Children s Hospital at Westmead, New South Wales, Australia
    Lancet 364:803-11. 2004
    ..In this review, we explore issues relating to trial participation for children and suggest some strategies for improving the conduct of clinical trials involving children...
  21. ncbi Systematic review of barriers to the recruitment of older patients with cancer onto clinical trials
    Carol A Townsley
    FRCPC, Department of Medical Oncology and Hematology, Princess Margaret Hospital, University Health Network, 610 University Ave, Suite 5 210, Toronto, Ontario, M5G 2M9, Canada
    J Clin Oncol 23:3112-24. 2005
    ....
  22. doi Questions and answers on the use of dabigatran and perspectives on the use of other new oral anticoagulants in patients with atrial fibrillation. A consensus document of the Italian Federation of Thrombosis Centers (FCSA)
    V Pengo
    Clinical Cardiology, Thrombosis Center, Padova, Italy
    Thromb Haemost 106:868-76. 2011
    ..In this report members of the board of the Italian Federation of Thrombosis Centers (FCSA) answer some questions every clinician might be confronted with...
  23. doi The challenges of clinical trials in the exclusion zone: the case of the frail elderly
    Iman Ridda
    The Children Hospital, National Center for Immunisation Research and Surveillance, Westmead, New South Wales, Australia
    Australas J Ageing 27:61-6. 2008
    ....
  24. doi Dabigatran etexilate for stroke prevention in patients with atrial fibrillation: resolving uncertainties in routine practice
    Menno V Huisman
    Department of Thrombosis and Haemostasis, Leiden University Medical Center, Leiden, The Netherlands
    Thromb Haemost 107:838-47. 2012
    ..In addition, cut-off values for different coagulation assay results associated with an increased risk of bleeding are given...
  25. doi Processes in recruitment to randomised controlled trials of medicines for children (RECRUIT): a qualitative study
    V Shilling
    Institute of Psychology, Health and Society, University of Liverpool, Liverpool, UK
    Health Technol Assess 15:1-116. 2011
    ....
  26. doi Optimization of patient selection for EGFR-TKIs in advanced non-small cell lung cancer by combined analysis of KRAS, PIK3CA, MET, and non-sensitizing EGFR mutations
    V Ludovini
    Medical Oncology Division, S Maria della Misericordia Hospital, 1, Via G Dottori, 06132 Perugia, Italy
    Cancer Chemother Pharmacol 69:1289-99. 2012
    ....
  27. ncbi How representative are clinical study patients with asthma or COPD for a larger "real life" population of patients with obstructive lung disease?
    Kjetil Herland
    Department of Community Medicine and General Practice, NTNU, Trondheim, Norway
    Respir Med 99:11-9. 2005
    ..It is questionable whether such data can extrapolated to a larger, "real life" population of patients with obstructive lung disease. Moreover, we found surprisingly minor differences between the Specialist and GP populations...
  28. pmc Do u smoke after txt? Results of a randomised trial of smoking cessation using mobile phone text messaging
    A Rodgers
    School of Population Health, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Tob Control 14:255-61. 2005
    ..To determine the effectiveness of a mobile phone text messaging smoking cessation programme...
  29. doi Patient selection for accelerated partial-breast irradiation (APBI) after breast-conserving surgery: recommendations of the Groupe Européen de Curiethérapie-European Society for Therapeutic Radiology and Oncology (GEC-ESTRO) breast cancer working group ba
    Csaba Polgar
    Department of Radiotherapy, National Institute of Oncology, Budapest, Hungary
    Radiother Oncol 94:264-73. 2010
    To give recommendations on patient selection criteria for the use of accelerated partial-breast irradiation (APBI) based on available clinical evidence complemented by expert opinion.
  30. ncbi External validity of randomised controlled trials: "to whom do the results of this trial apply?"
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Lancet 365:82-93. 2005
    ..This review discusses those determinants, presents a checklist for clinicians, and makes recommendations for greater consideration of external validity in the design and reporting of RCTs...
  31. ncbi Informed patient consent to participation in cluster randomized trials: an empirical exploration of trials in primary care
    Sandra M Eldridge
    Centre for General Practice and Primary Care, Institute of Community Health Sciences, Queen Mary, University of London, UK
    Clin Trials 2:91-8. 2005
    ..A more public debate may clarify the general acceptability of not obtaining consent in certain situations...
  32. doi Investigating socio-economic disparities in preterm birth: evidence for selective study participation and selection bias
    Michael S Kramer
    Department of Pediatrics, McGill University Faculty of Médecine, Montreal, Quebec, Canada
    Paediatr Perinat Epidemiol 23:301-9. 2009
    ..Investigators should consider the potential for biased associations in pregnancy/birth cohort studies, especially associations based on SES or race/ethnicity, and carry out sensitivity analyses to gauge their effects...
  33. doi Defining the "edge of the envelope": patient selection in treating complex sellar-based neoplasms via transsphenoidal versus open craniotomy
    Gabriel Zada
    Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosurg 114:286-300. 2011
    ....
  34. doi Real-time 3D echo in patient selection for cardiac resynchronization therapy
    Stamatis Kapetanakis
    Department of Cardiology, King s College Hospital, Denmark Hill, London, United Kingdom
    JACC Cardiovasc Imaging 4:16-26. 2011
    this study investigated the use of 3-dimensional (3D) echo in quantifying left ventricular mechanical dyssynchrony (LVMD), its interhospital agreement, and potential impact on patient selection.
  35. pmc Who is the research subject in cluster randomized trials in health research?
    Andrew D McRae
    Department of Epidemiology and Biostatistics, University of Western Ontario, London, Canada
    Trials 12:183. 2011
    ..Individuals who are indirectly affected by CRT study interventions, including patients of healthcare providers participating in knowledge translation CRTs, are not human research subjects unless at least one of these conditions is met...
  36. doi Overweight children and adolescents--is there a subjective need for treatment?
    Emily Finne
    Institute of Public Health and Nursing Research IPP, University of Bremen, P O Box 330 440, D 28334, Bremen, Germany
    Int J Public Health 54:112-6. 2009
    ..We report on the first months of recruitment for a study to evaluate outpatient training for moderately overweight youths...
  37. ncbi Recruitment and retention of adolescents in a smoking trajectory study: who participates and lessons learned
    Kathleen R Diviak
    University of Illinois, Chicago, Illinois 60608, USA
    Subst Use Misuse 41:175-82. 2006
    ..Chi-square and multivariate analyses revealed no significant differences in retention on the demographic, smoking experience, or psychosocial variables measured. Implications of the results and study limitations are discussed...
  38. pmc Developing an HIV behavioral surveillance system for injecting drug users: the National HIV Behavioral Surveillance System
    Amy Lansky
    Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Public Health Rep 122:48-55. 2007
    ..S. that will provide local and national data on risk for HIV and other blood-borne and sexually transmitted infections among IDUs for monitoring changes in the epidemic and prevention programs...
  39. pmc On-line randomized controlled trial of an internet based psychologically enhanced intervention for people with hazardous alcohol consumption
    Paul Wallace
    e Health Unit, Research Department of Primary Care and Population Health, University College London, London, United Kingdom
    PLoS ONE 6:e14740. 2011
    ..DYD-RCT Trial registration: ISRCTN 31070347...
  40. ncbi Quality of life at the end of primary treatment of breast cancer: first results from the moving beyond cancer randomized trial
    Patricia A Ganz
    School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    J Natl Cancer Inst 96:376-87. 2004
    ..We investigated the baseline psychosocial status of women enrolled in a randomized trial testing two psychosocial interventions for women at the end of primary treatment...
  41. ncbi Baseline characteristics and statistical power in randomized controlled trials: selection, prognostic targeting, or covariate adjustment?
    Bob Roozenbeek
    Department of Public Health, Center for Medical Decision Making, Erasmus MC, Rotterdam, The Netherlands
    Crit Care Med 37:2683-90. 2009
    ..We aimed to investigate the potential benefits of different approaches for dealing with heterogeneity in a case study on traumatic brain injury (TBI)...
  42. doi Neural grafting in Parkinson's disease unraveling the mechanisms underlying graft-induced dyskinesia
    Emma L Lane
    Welsh School of Pharmacy, Cardiff University, South Wales, UK
    Prog Brain Res 184:295-309. 2010
    ..Based on the available clinical and preclinical data we outline strategies to avoid GID in future clinical trials using fetal cell transplants or cell preparations derived from stem cells...
  43. doi Clinical trials: the challenge of recruitment and retention of participants
    Raisa B Gul
    School of Nursing, Aga Khan University, Karachi, Pakistan
    J Clin Nurs 19:227-33. 2010
    ..This article, based on the available literature, attempts to discuss the importance of recruitment and retention of research participants, the associated barriers and challenges, and various strategies to overcome these barriers...
  44. doi Prospective validation of a prognostic score to improve patient selection for oncology phase I trials
    Hendrik Tobias Arkenau
    Royal Marsden Hospital and Institute of Cancer Research, Drug Development Unit, Sutton, UK
    J Clin Oncol 27:2692-6. 2009
    With the aim of improving patient selection for phase I trials, we previously performed a retrospective analysis of 212 phase I oncology patients where we were able to develop a prognostic score predicting overall survival (OS)...
  45. ncbi Cohort Profile: the Australian Longitudinal Study on Women's Health
    Christina Lee
    School of Psychology, University of Queensland, St Lucia, QLD, Australia
    Int J Epidemiol 34:987-91. 2005
  46. ncbi Validation of gene signatures that predict the response of breast cancer to neoadjuvant chemotherapy: a substudy of the EORTC 10994/BIG 00-01 clinical trial
    Herve Bonnefoi
    Geneva University Hospital, Geneva, Switzerland
    Lancet Oncol 8:1071-8. 2007
    ..The aim of this study was to confirm the validity of these gene-expression signatures in a large series of patients with oestrogen-receptor-negative breast tumours who were treated in a phase III neoadjuvant clinical trial...
  47. pmc Identifying strategies to maximise recruitment and retention of practices and patients in a multicentre randomised controlled trial of an intervention to optimise secondary prevention for coronary heart disease in primary care
    Claire S Leathem
    Department of General Practice, National University of Ireland, Galway, Ireland
    BMC Med Res Methodol 9:40. 2009
    ..We sought to describe a strategy used in a multicentre RCT in primary care, to report researchers' and participants' experiences of its implementation and to inform future strategies to maximise recruitment and retention...
  48. doi Development of a complex intervention improved randomization and informed consent in a randomized controlled trial
    Jenny L Donovan
    Department of Social Medicine, University of Bristol, Bristol BS8 2PR, UK
    J Clin Epidemiol 62:29-36. 2009
    ..Systematic reviews failed to identify robust strategies to improve recruitment. We developed and evaluated a complex intervention to increase levels of randomization and informed consent...
  49. ncbi Clinical application of airway bypass with paclitaxel-eluting stents: early results
    Paulo F G Cardoso
    Department of Surgery, Division of Thoracic Surgery, Santa Casa de Porto Alegre Pavilhao Pereira Filho Hospital, Fundacao Faculdade Federal de Ciencias Medicas de Porto Alegre, Porto Alegre RS, Brazil
    J Thorac Cardiovasc Surg 134:974-81. 2007
    ..To assess the safety and early clinical results of a multicenter evaluation of airway bypass with paclitaxel-eluting stents for selected patients with severe emphysema...
  50. ncbi Barriers to recruiting underrepresented populations to cancer clinical trials: a systematic review
    Jean G Ford
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Cancer 112:228-42. 2008
    ....
  51. ncbi Dietary habits and stomach cancer in Mizoram, India
    Rup Kumar Phukan
    Regional Medical Research Centre, NE Region ICMR, Dibrugarh, Assam, India
    J Gastroenterol 41:418-24. 2006
    ..An extremely high prevalence of stomach cancer was observed in Mizoram (India), where the population consumes uncommon food. The relation of food habits and stomach cancer was examined in this study...
  52. ncbi Recruitment and retention of an online sample for an HIV prevention intervention targeting men who have sex with men: the Smart Sex Quest Project
    S Salyers Bull
    Colorado Health Outcomes Program, University of Colorado Health Sciences Center, Aurora, CO 80045 0508, USA
    AIDS Care 16:931-43. 2004
    ..Alternate ways to recruit for and evaluate online trials must be considered...
  53. pmc The Newcastle 85+ study: biological, clinical and psychosocial factors associated with healthy ageing: study protocol
    Joanna Collerton
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    BMC Geriatr 7:14. 2007
    ....
  54. ncbi Identification of candidate molecular markers predicting sensitivity in solid tumors to dasatinib: rationale for patient selection
    Fei Huang
    Departments of Clinical Discovery and Oncology Discovery, Bristol Myers Squibb Co, Princeton, NJ 08543, USA
    Cancer Res 67:2226-38. 2007
    ..were observed in a subset of primary breast, lung, and ovarian tumors suggesting potential utility in patient selection. The subset of breast cancer patients expressing the dasatinib-sensitive signature includes a distinct ..
  55. ncbi Nonoperative management of blunt splenic injury: a 5-year experience
    James M Haan
    R Adams Cowley Shock Trauma Center, University of Maryland Medical Center, Baltimore, Maryland 21201, USA
    J Trauma 58:492-8. 2005
    ..The purpose of this study was to examine the success rate of nonoperative management of blunt splenic injury in an institution using splenic embolization...
  56. ncbi Resection for hepatocellular carcinoma is a good option in Child-Turcotte-Pugh class A patients with cirrhosis who are eligible for liver transplantation
    Carlos Margarit
    Liver Transplantation Unit, Department of Surgery, Hospital Vall Hebron, Universidad Autonoma, Barcelona, Spain
    Liver Transpl 11:1242-51. 2005
    ..Salvage liver transplantation was performed in 16.2% of resected patients, with older age being the main contraindication. Outcome of salvage LT was similar to that of primary LT...
  57. ncbi Randomised controlled trials in overweight children: practicalities and realities
    Janet M Warren
    University of Newcastle, Schools of Health Sciences and Education, Callaghan Campus, Newcastle, New South Wales, Australia
    Int J Pediatr Obes 2:73-85. 2007
    ..To highlight and discuss the practical aspects of conducting high quality, randomised controlled trials (RCTs) with overweight and obese children and their families...
  58. doi Noninvasive evaluation of the aortic root with multislice computed tomography implications for transcatheter aortic valve replacement
    Laurens F Tops
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    JACC Cardiovasc Imaging 1:321-30. 2008
    ..In the present study, the anatomy of the aortic root was assessed noninvasively with multislice computed tomography (MSCT)...
  59. ncbi The Chronic Renal Insufficiency Cohort (CRIC) Study: Design and Methods
    Harold I Feldman
    Center for Clinical Epidemiology, Philadelphia, 19104, USA
    J Am Soc Nephrol 14:S148-53. 2003
    ..Insights from CRIC should lead to the formulation of hypotheses regarding therapy that will serve as the basis for targeted interventional trials focused on reducing the burden of CRI and CVD...
  60. pmc The assessment of the prognosis of musculoskeletal conditions in older adults presenting to general practice: a research protocol
    Christian D Mallen
    Primary Care Musculoskeletal Research Centre, Keele University, UK
    BMC Musculoskelet Disord 7:84. 2006
    ..This study will test a generic assessment tool used as part of the general practice consultation to determine prognosis of musculoskeletal complaints...
  61. pmc Born in Bradford, a cohort study of babies born in Bradford, and their parents: protocol for the recruitment phase
    Pauline Raynor
    Bradford Institute for Health Research, Bradford Royal Infirmary, Duckworth Lane, Bradford, BD9 6RJ, UK
    BMC Public Health 8:327. 2008
    ..This protocol outlines methods for the recruitment phase of the study...
  62. ncbi Biochemical outcomes after prostate brachytherapy with 5-year minimal follow-up: importance of patient selection and implant quality
    Marisa A Kollmeier
    Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Radiat Oncol Biol Phys 57:645-53. 2003
    ..Patients treated during the first 6 years of the program were analyzed to determine the value of patient selection and implant quality on biochemical control.
  63. ncbi A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
    Katrien Berns
    Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Cancer Cell 12:395-402. 2007
    ..Thus, assessment of PI3K pathway activation may provide a biomarker to identify patients unlikely to respond to trastuzumab-based therapy...
  64. pmc Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics
    Federico Innocenti
    The University of Chicago, Chicago, IL 60637, USA
    J Clin Oncol 27:2604-14. 2009
    ..We aim to identify genetic variation, in addition to the UGT1A1*28 polymorphism, that can explain the variability in irinotecan (CPT-11) pharmacokinetics and neutropenia in cancer patients...
  65. ncbi Impact of participant and physician intervention preferences on randomized trials: a systematic review
    Michael King
    Department of Mental Health Sciences, Royal Free and University College Medical School, Royal Free Campus, London, England
    JAMA 293:1089-99. 2005
    ..However, randomly allocating patients to treatments that do not accord with their preferences may influence internal and external validity...
  66. pmc Comparing two web-based smoking cessation programs: randomized controlled trial
    H Garth McKay
    Oregon Research Institute, 1715 Franklin Boulevard, Eugene, OR 97403, USA
    J Med Internet Res 10:e40. 2008
    ..To date, the relatively few controlled trials of Web-based smoking cessation programs have been limited by short follow-up intervals...
  67. ncbi Trichuris suis seems to be safe and possibly effective in the treatment of inflammatory bowel disease
    Robert W Summers
    Department of Internal Medicine, James A Clifton Center for Digestive Diseases, University of Iowa Health Care, Iowa City, Iowa, USA
    Am J Gastroenterol 98:2034-41. 2003
    ..Induction of a Th2 immune response by intestinal helminths diminishes Th1 responsiveness. This study evaluates the safety and effectiveness of helminthic ova in the treatment of active IBD...
  68. pmc Effectiveness of thigh-length graduated compression stockings to reduce the risk of deep vein thrombosis after stroke (CLOTS trial 1): a multicentre, randomised controlled trial
    M Dennis
    Division of Clinical Neurosciences, University of Edinburgh, Bramwell Dott Building, Western General Hospital, Edinburgh EH4 2XU, UK
    Lancet 373:1958-65. 2009
    ..National stroke guidelines extrapolating from these trials recommend their use in patients with stroke despite insufficient evidence. We assessed the effectiveness of thigh-length GCS to reduce DVT after stroke...
  69. ncbi A risk model for prediction of lung cancer
    Margaret R Spitz
    Department of Epidemiology Unit 1340, The University of Texas M D Anderson Cancer Center, PO Box 301439, Houston, TX 77230 1439, USA
    J Natl Cancer Inst 99:715-26. 2007
    ..Reliable risk prediction tools for estimating individual probability of lung cancer have important public health implications. We constructed and validated a comprehensive clinical tool for lung cancer risk prediction by smoking status...
  70. ncbi Intention-to-treat analysis: who is in? Who is out?
    Robin L Kruse
    Department of Family Community Medicine, University of Missouri Columbia School of Medicine, M228 Medical Sciences Bldg, Columbia, MO 65212, USA
    J Fam Pract 51:969-71. 2002
    ..Nineteen of the 92 studies excluded more than 5% of randomized participants, and 10 excluded more than 10%. There is considerable variation in how researchers define and apply the principle of intention to treat...
  71. ncbi Guidelines on the management of valvular heart disease: The Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology
    Alec Vahanian
    Service de cardiologie, Hôpital Bichat AP HP, Paris, France
    Eur Heart J 28:230-68. 2007
  72. ncbi Prediction of response to preoperative chemotherapy in adenocarcinomas of the esophagogastric junction by metabolic imaging
    W A Weber
    Departments of Nuclear Medicine, Surgery, Pathology, Radiology, and Medical Statistics, Technische Universitat Munchen, Munchen, Germany
    J Clin Oncol 19:3058-65. 2001
    ..This study evaluates whether positron emission tomography (PET) using fluorine-18 fluorodeoxyglucose (FDG) may predict response early in the course of therapy...
  73. pmc Recruiting adolescent girls into a follow-up study: benefits of using a social networking website
    Lindsey Jones
    Department of Epidemiology and Biostatistics University of Maryland School of Public Health University of Maryland, College Park College Park, MD 20742, United States
    Contemp Clin Trials 33:268-72. 2012
    ..Recruitment and retention of adolescent research participants presents unique challenges and considerations when conducting epidemiological studies...
  74. pmc Collaborative Interventions for Circulation and Depression (COINCIDE): study protocol for a cluster randomized controlled trial of collaborative care for depression in people with diabetes and/or coronary heart disease
    Peter A Coventry
    Greater Manchester Collaboration for Leadership in Applied Health Research and Care, Institute of Population Health and Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
    Trials 13:139. 2012
    ..The study also aimed to evaluate the cost-effectiveness of the intervention over 6 months, and to assess qualitatively the extent to which collaborative care was implemented in the intervention general practices...
  75. ncbi Feasibility of recruiting a birth cohort through the Internet: the experience of the NINFEA cohort
    Lorenzo Richiardi
    Cancer Epidemiology Unit, CeRMS and Center for Oncologic Prevention, University of Turin, V Santena 7, 10126, Turin, Italy
    Eur J Epidemiol 22:831-7. 2007
    ..As with many other types of birth cohort study, the participants are a self-selected sample. To minimise selection bias analyses should therefore be limited to internal comparisons...
  76. pmc Serum vascular endothelial growth factor and fibronectin predict clinical response to high-dose interleukin-2 therapy
    Marianna Sabatino
    Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Warren G Magnuson Clinical Center, NIH, Bethesda, MD, USA
    J Clin Oncol 27:2645-52. 2009
    ..High-dose interleukin-2 (IL-2) induces durable therapeutic responses in a small subset of patients with metastatic melanoma and renal cell carcinoma, but simple pretreatment predictors of response have not been identified...
  77. ncbi Criteria for patient selection and multidisciplinary evaluation and treatment of the weight loss surgery patient
    Edward Saltzman
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Obes Res 13:234-43. 2005
    To provide evidence-based guidelines for patient selection and to recommend the medical and nutritional aspects of multidisciplinary care required to minimize perioperative and postoperative risks in patients with severe obesity who ..
  78. ncbi Palliative goals, patient selection, and perioperative platelet management: outcomes and lessons from 3 decades of splenectomy for myelofibrosis with myeloid metaplasia at the Mayo Clinic
    Ruben A Mesa
    Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer 107:361-70. 2006
    ..The authors retrospectively analyzed their experience with splenectomy over the course of 30 years to analyze the impact of improved techniques, antimicrobials, and aggressive postoperative control of platelet counts on outcome...
  79. pmc Bariatric surgery waiting times in Canada
    Nicolas V Christou
    Department of Surgery, Division of General Surgery, McGill University, McGill University Health Centre, Montreal, Que
    Can J Surg 52:229-34. 2009
    ..The only permanent treatment of severe or morbid obesity is bariatric surgery. Access to bariatric surgery is very limited in Canada. We sought to collect accurate data on waiting times for the procedure...
  80. pmc Ethical issues posed by cluster randomized trials in health research
    Charles Weijer
    Rotman Institute of Philosophy, Department of Philosophy, University of Western Ontario, London, ON, N6A 5B8, Canada
    Trials 12:100. 2011
    ..Our hope is that these papers will serve as the basis for the creation of international ethical guidelines for the design and conduct of cluster randomized trials...
  81. ncbi Management of coronary artery fistulae. Patient selection and results of transcatheter closure
    Laurie R Armsby
    Department of Cardiology, The Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 39:1026-32. 2002
    ..We report short-term findings in 33 patients after transcatheter closure (TCC) of coronary artery fistulae (CAF) and compare our results with those reported in the recent transcatheter and surgical literature...
  82. doi Target populations for first-in-human embryonic stem cell research in spinal cord injury
    Frederic Bretzner
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia B3H 3J5, Canada
    Cell Stem Cell 8:468-75. 2011
    ....
  83. doi Cost-effectiveness of coronary computed tomography and cardiac stress imaging in the emergency department: a decision analytic model comparing diagnostic strategies for chest pain in patients at low risk of acute coronary syndromes
    Virginia L Priest
    Centre for Applied Health Economics, School of Medicine, Griffith University, Brisbane, Queensland, Australia
    JACC Cardiovasc Imaging 4:549-56. 2011
    ..Large comparative, randomized, controlled trials of the different diagnostic strategies are needed to compare the long-term costs and consequences of each strategy in a population of defined low-risk patients in the emergency department...
  84. doi Family income and survival in Brazilian Peritoneal Dialysis Multicenter Study Patients (BRAZPD): time to revisit a myth?
    Kleyton de Andrade Bastos
    Department of Medicine, Federal University of Sergipe, Aracaju, Brazil
    Clin J Am Soc Nephrol 6:1676-83. 2011
    ..The goal of this study was assessing the effect of income on survival in the Brazilian Peritoneal Dialysis Multicenter STUDY...
  85. pmc Is recruitment more difficult with a placebo arm in randomised controlled trials? A quasirandomised, interview based study
    A J Welton
    Medical Research Council Epidemiology and Medical Care Unit, Wolfson Institute of Preventive Medicine, St Bartholomew s and Royal London Hospital School of Medicine and Dentistry, London ECIM 6BQ
    BMJ 318:1114-7. 1999
    ..To investigate whether including a placebo arm in a clinical trial of hormone replacement therapy influenced women's stated willingness to participate...
  86. ncbi Clinical predictors of upgrading to Gleason grade 4 or 5 disease at radical prostatectomy: potential implications for patient selection for radiation and androgen suppression therapy
    A V D'Amico
    Dana Farber Cancer Institute, Department of Radiation Oncology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Int J Radiat Oncol Biol Phys 45:841-6. 1999
    ....
  87. pmc Disclosure of investigators' recruitment performance in multicenter clinical trials: a further step for research transparency
    Rafael Dal-Ré
    Early Detection Research Program, Alzheimer s Disease, Pasqual Maragall Foundation, Barcelona, Spain
    PLoS Med 8:e1001149. 2011
    ..Rafael Dal-Ré and colleagues argue that the recruitment targets and performance of all site investigators in multi-centre clinical trials should be disclosed in trial registration sites before a trial starts, and when it ends...
  88. doi Clinical management of continuous-flow left ventricular assist devices in advanced heart failure
    Mark S Slaughter
    University of Louisville, Louisville, Kentucky, USA
    J Heart Lung Transplant 29:S1-39. 2010
    ..b>Patient selection, pre-operative preparation, and the timing of LVAD implant are some of the most important elements critical ..
  89. doi 2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design
    Hugh Calkins
    Johns Hopkins Hospital, Baltimore, MD, USA
    J Interv Card Electrophysiol 33:171-257. 2012
    ..This is endorsed by the governing bodies of the ACC Foundation, the AHA, the ECAS, the EHRA, the STS, the APHRS, and the HRS...
  90. pmc Costs and difficulties of recruiting patients to provide e-health support: pilot study in one primary care trust
    Ray B Jones
    Faculty of Health, Education and Society, Plymouth University, Plymouth PL4 8AA, UK
    BMC Med Inform Decis Mak 12:25. 2012
    ..This pilot study explored the feasibility and cost of recruiting patients for an e-health intervention in one primary care trust...
  91. pmc Methodology of the Interventional Management of Stroke III Trial
    Pooja Khatri
    Department of Neurology, University of Cincinnati, 231 Albert Sabin Way ML 0525, Cincinnati, OH 45267 0525, USA
    Int J Stroke 3:130-7. 2008
    ..a.) approach to recanalization may be more effective than standard i.v. rt-PA (Activase) alone for moderate-to-large National Institutes of Health Stroke Scale (NIHSS>or=10) strokes, and with a similar safety profile...
  92. ncbi Challenges for patient selection with VEGF inhibitors
    R Longo
    Division of Medical Oncology, San Filippo Neri Hospital, Via Martinotti 20, 00135 Rome, Italy
    Cancer Chemother Pharmacol 60:151-70. 2007
    ..Further research is needed to define the relationship between potential surrogate markers of VEGF pathway activity and clinical outcomes...
  93. ncbi Cohort profile: the Norwegian Mother and Child Cohort Study (MoBa)
    Per Magnus
    Division of Epidemiology, The Norwegian Institute of Public Health, Oslo, Norway
    Int J Epidemiol 35:1146-50. 2006
  94. doi Can molecular biomarker-based patient selection in Phase I trials accelerate anticancer drug development?
    Craig P Carden
    Drug Development Unit, Royal Marsden Hospital, Marsden Hospital, Sutton, Surrey SM2 5PT, UK
    Drug Discov Today 15:88-97. 2010
    ..In this review, we suggest a new model of early clinical trial design, which incorporates patient selection through predictive molecular biomarkers for selected targeted agents.
  95. doi Results of the Predictors of Response to CRT (PROSPECT) trial
    Eugene S Chung
    Lindner Clinical Trial Center, Cincinnati, OH 45219, USA
    Circulation 117:2608-16. 2008
    ..from single-center studies suggest that echocardiographic parameters of mechanical dyssynchrony may improve patient selection for cardiac resynchronization therapy (CRT)...
  96. pmc Circumferential myocardial strain in cardiomyopathy with and without left bundle branch block
    Yuchi Han
    Departments of Medicine Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Cardiovasc Magn Reson 12:2. 2010
    ....
  97. pmc Trials within trials? Researcher, funder and ethical perspectives on the practicality and acceptability of nesting trials of recruitment methods in existing primary care trials
    Jonathan Graffy
    NIHR School for Primary Care Research, University of Cambridge, Cambridge, UK
    BMC Med Res Methodol 10:38. 2010
    ..A robust test of recruitment methods involves comparing alternative methods using a randomized trial, 'nested' in an ongoing 'host' trial. There are potential scientific, logistical and ethical obstacles to such studies...
  98. pmc Falls Assessment Clinical Trial (FACT): design, interventions, recruitment strategies and participant characteristics
    C Raina Elley
    Department of General Practice and Primary Health Care, School of Population Health, University of Auckland, New Zealand
    BMC Public Health 7:185. 2007
    ..We describe the rationale, intervention, study design, recruitment strategies and baseline characteristics of participants in a randomised controlled trial of a multifactorial falls prevention programme in primary health care...
  99. pmc Clinical benefit in Phase-I trials of novel molecularly targeted agents: does dose matter?
    S Postel-Vinay
    Royal Marsden Hospital and The Institute of Cancer Research, Drug Development Unit, Downs Road, SM2 5PT, Sutton, UK
    Br J Cancer 100:1373-8. 2009
    ..9. Our analysis suggests that the potential for clinical benefit is not confined to patients treated at doses close to the MTD in Phase-I trials of MTAs...
  100. pmc Case-finding instruments for depression. Two questions are as good as many
    M A Whooley
    General Internal Medicine Section, San Francisco Department of Veterans Affairs Medical Center, CA 94121, USA
    J Gen Intern Med 12:439-45. 1997
    ..82 to 0.89. CONCLUSIONS: The two-question case-finding instrument is a useful measure for detecting depression in primary care. It has similar test characteristics to other case-finding instruments and is less time-consuming...
  101. doi Analysis of complications in patients treated with the X-Stop Interspinous Process Decompression System: proposal for a novel anatomic scoring system for patient selection and review of the literature
    Giuseppe M V Barbagallo
    Department of Neurosurgery, Azienda Ospedaliero Universitaria Policlinico G Rodolico, Catania, Italy
    Neurosurgery 65:111-19; discussion 119-20. 2009
    ..The aim of this study was to analyze a series of complications occurring at a single institution and their potential causes and propose an anatomic scoring system that may help to classify patients and prevent complications...

Research Grants90

  1. Sex-Hormones and the TMPRSS2: ERG Fusion in Prostate Cancer Progression
    Lorelei Mucci; Fiscal Year: 2010
    ..public health impact, and illuminate opportunities for primary and secondary prevention or improved patient selection for specific therapeutic intervention...
  2. Dengue Epitope Vaccine,Tetravalent & MHCII-Targeted
    J Thomas August; Fiscal Year: 2007
    ..This assay will be applied to patient selection for the Core B cohort...
  3. Speech Intelligibility Testing in Children with Repaired Cleft Palate
    David Zajac; Fiscal Year: 2007
    ..are expected to a) provide meaningful data to guide both surgical and behavioral interventions relative to patient selection and/or phonetic contrast priorities, b) suggest a different etiology for frequently occurring backed ..
  4. Biomarkers in Phototherapy of Barrett's Esophagus
    Kenneth Wang; Fiscal Year: 2006
    ..will help to define the role of photodynamic therapy in mucosal ablation of Barrett's esophagus in terms of patient selection and biomarkers that may predict response to therapy...
  5. Sex-Hormones and the TMPRSS2: ERG Fusion in Prostate Cancer Progression
    Lorelei Mucci; Fiscal Year: 2009
    ..public health impact, and illuminate opportunities for primary and secondary prevention or improved patient selection for specific therapeutic intervention...
  6. MED1 MUTATIONS IN COLORECTAL CANCER
    Alfonso Bellacosa; Fiscal Year: 2002
    The therapy of metastatic colorectal cancer is largely unsatisfactory and new treatments or improved patient selection for the currently available treatments are greatly needed...
  7. Study of design variables of the endovascular graft
    MADHAVAN RAGHAVAN; Fiscal Year: 2007
    ..the market and their relative merits are unclear, which forces the physician to make choices on devices and patient selection using questionable criteria...
  8. LIVER TRANSPLANTATION--MODELS FOR OPTIMIZING OUTCOMES
    E Dickson; Fiscal Year: 1993
    ..We now plan to: 1) develop methods for patient selection and OLT timing that maximize patient and graft survival; 2) determine the effect of optimal selection and ..
  9. Autonomic Disorders Programs Project
    Phillip Low; Fiscal Year: 2007
    ..CAP Core is responsible for patient selection, patient screening and recruitment, performing baseline and follow-up autonomic studies, coordinating ..
  10. LV Structural Predictors of Sudden Cardiac Death
    Katherine C Wu; Fiscal Year: 2010
    ..in using current practice guidelines of LV ejection fraction (LVEF) d 35% as the main determining factor for patient selection, only a minority of patients actually benefit from ICD therapy (<25% in 5 years)...
  11. Aerosolized hyaluronic acid as a treatment for COPD
    Gerard Turino; Fiscal Year: 2006
    ..include a total of 48 patients with COPD, at least 10 pack-years of cigarette use, and meeting additional patient selection criteria...
  12. Rheumatoid Arthritis Induction Trial (RAITMAT)
    Larry Moreland; Fiscal Year: 2007
    ..important objective of the proposed trial will be to identify proteomic and/or genomic biomarkers to guide patient selection and therapy...
  13. Medialization VS. Reinnervation For Vocal Cord Paralysis
    Jay Piccirillo; Fiscal Year: 2004
    ..Previous studies comparing these approaches have been small and limited by significant non-randomized patient selection bias. The study design is a multicenter, prospective, randomized clinical trial...
  14. Conference on Chiropractic and Allopathic Integration
    THOMAS VENTIMGLIA; Fiscal Year: 2003
    ..g. patient selection, health data collection, diagnostic development, therapeutic selection and intervention, interdisciplinary ..
  15. COST-EFFECTIVENESS ANALYSIS OF SURGERY IN EPILEPSY-CEASE
    John Langfitt; Fiscal Year: 2001
    ..provider based characteristics associated with lower costs and better outcomes will lead to improvements in patient selection and quality of care...
  16. Measuring Left Ventricular Dyssynchrony from ECG-gated Myocardial Perfusion SPECT
    Ji Chen; Fiscal Year: 2010
    ..Echocardiography has shown to improve patient selection for CRT, but it requires expertise to obtain reliable results...
  17. An XFM Interventional Guidance System for Cardiac Resynchronization Therapy
    Reza Nezafat; Fiscal Year: 2010
    ..that these elements are key determinants of clinical outcomes for CRT and that they should be used for patient selection, procedural planning, and guidance of CRT...
  18. SEARCH FOR GENES INFLUENCING CHILDHOOD ABSENCE EPILEPSY
    Martina Durner; Fiscal Year: 2003
    ..of heterogeneity in genetic analysis and will minimize it by strict phenotype definition and stringent patient selection criteria. This strategy has been shown to be the key issue in our success in JME...
  19. Impact of Pancreas-Kidney Transplants on Renal Allograft
    Ajay Israni; Fiscal Year: 2002
    ..However, patient selection may account for this disparity since patient sociodemographics and comorbidities likely impact consideration ..
  20. Hypocaloric Nutrition and Outcomes in Critically 111 Patients
    ROSEMARIE METZGER; Fiscal Year: 2007
    ..Subsequently, clinical practice guidelines have been established to provide a framework for patient selection, timing and route of administration, and strategies to optimize delivery and monitoring of nutrition support...
  21. EATING BEHAVIOR AFTER GASTRIC BYPASS
    L K Hsu; Fiscal Year: 2001
    ..because a better understanding of the outcome and the prognostic indicators of GBP may allow better patient selection and the implementation of adjunctive treatments such as cognitive therapy or anti-obesity medications for ..