Genomes and Genes
Summary: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Articles from Journal RESEARCH
Articles from Journal RESEARCH1
Publications357 found, 100 shown here
- Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyondMichael J Pencina
Department of Mathematics and Statistics, Framingham Heart Study, Boston University, Boston, MA 02215, USA
Stat Med 27:157-72; discussion 207-12. 2008..We illustrate the use of these measures with an example from the Framingham Heart Study. We propose that scientists consider these types of measures in addition to the AUC when assessing the performance of newer biomarkers...
- A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010Stephen S Lim
Institute for Health Metrics and Evaluation, Seattle, WA 98121, USA
Lancet 380:2224-60. 2012..No complete revision of global disease burden caused by risk factors has been done since a comparative risk assessment in 2000, and no previous analysis has assessed changes in burden attributable to risk factors over time.
- General cardiovascular risk profile for use in primary care: the Framingham Heart StudyRALPH B D'AGOSTINO
Boston University, Department of Mathematics and Statistics, 111 Cummington St, Boston, MA 02215, USA
Circulation 117:743-53. 2008..The present report presents a single multivariable risk function that predicts risk of developing all CVD and of its constituents...
- Extensions of net reclassification improvement calculations to measure usefulness of new biomarkersMichael J Pencina
Department of Biostatistics, Boston University, 801 Massachusetts Ave, Boston, MA 02118, USA
Stat Med 30:11-21. 2011..We recommend that researchers clearly define and justify the choices they make when choosing NRI for their application...
- Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial FibrillationB F Gage
Division of General Medical Sciences, Washington University School of Medicine Campus, Box 8005, 660 S Euclid Ave, St Louis, MO 63110, USA
JAMA 285:2864-70. 2001..Patients who have atrial fibrillation (AF) have an increased risk of stroke, but their absolute rate of stroke depends on age and comorbid conditions...
- Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillationGregory Y H Lip
University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK
Chest 137:263-72. 2010..Thus, many potential risk factors have not been included...
- 2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertensionJudith A Whitworth
John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Hypertens 21:1983-92. 2003....
- Assessing the performance of prediction models: a framework for traditional and novel measuresEwout W Steyerberg
Department of Public Health, Erasmus MC, Rotterdam, The Netherlands
Epidemiology 21:128-38. 2010..Other measures of performance may be warranted in specific applications, such as reclassification metrics to gain insight into the value of adding a novel predictor to an established model...
- The diabetes risk score: a practical tool to predict type 2 diabetes riskJaana Lindström
Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
Diabetes Care 26:725-31. 2003..Interventions to prevent type 2 diabetes should be directed toward individuals at increased risk for the disease. To identify such individuals without laboratory tests, we developed the Diabetes Risk Score...
- C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysisStephen Kaptoge
Emerging Risk Factors Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
Lancet 375:132-40. 2010..We assessed the associations of CRP concentration with risk of vascular and non-vascular outcomes under different circumstances...
- Neonicotinoids in bees: a review on concentrations, side-effects and risk assessmentTjeerd Blacquière
Plant Research International, Wageningen University and Research, Wageningen, The Netherlands
Ecotoxicology 21:973-92. 2012..for sublethal effects, and (3) the usefulness for the evaluation of neonicotinoids of an already existing risk assessment scheme for systemic compounds...
- Validation of the Framingham coronary heart disease prediction scores: results of a multiple ethnic groups investigationR B D'Agostino
Department of Mathematics and Statistics, Boston University, 111 Cummington St, Boston, MA 02215, USA
JAMA 286:180-7. 2001..Concern exists regarding whether these functions can be generalized to other populations...
- The metabolic syndrome and cardiovascular risk a systematic review and meta-analysisSalvatore Mottillo
Jewish General Hospital McGill University, Montreal, Quebec, Canada
J Am Coll Cardiol 56:1113-32. 2010....
- Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studiesM R Law
Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ
BMJ 338:b1665. 2009..To determine the quantitative efficacy of different classes of blood pressure lowering drugs in preventing coronary heart disease (CHD) and stroke, and who should receive treatment...
- A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart SurveyRon Pisters
Department of Cardiology, Maastricht University Medical Centre, Maastricht, The Netherlands
Chest 138:1093-100. 2010..We aimed to develop a practical risk score to estimate the 1-year risk for major bleeding (intracranial, hospitalization, hemoglobin decrease > 2 g/L, and/or transfusion) in a cohort of real-world patients with AF...
- Comparison of novel risk markers for improvement in cardiovascular risk assessment in intermediate-risk individualsJoseph Yeboah
Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
JAMA 308:788-95. 2012....
- Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trialsColin Baigent
CTSU, Oxford University, Oxford, UK
Lancet 373:1849-60. 2009..Low-dose aspirin is of definite and substantial net benefit for many people who already have occlusive vascular disease. We have assessed the benefits and risks in primary prevention...
- Predictors of hospital mortality in the global registry of acute coronary eventsChristopher B Granger
Division of Cardiology, University Medical Center, Durham, NC, USA
Arch Intern Med 163:2345-53. 2003..Management of acute coronary syndromes (ACS) should be guided by an estimate of patient risk...
- The use of fractional polynomials to model continuous risk variables in epidemiologyP Royston
Department of Medical Statistics and Evaluation, Imperial College School of Medicine, London, UK
Int J Epidemiol 28:964-74. 1999..The traditional method of analysing continuous or ordinal risk factors by categorization or linear models may be improved...
- Use and misuse of the receiver operating characteristic curve in risk predictionNancy R Cook
Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave East, Boston, MA 02215, USA
Circulation 115:928-35. 2007..As novel risk factors are discovered, sole reliance on the c statistic to evaluate their utility as risk predictors thus seems ill-advised...
- Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysisF G R Fowkes
JAMA 300:197-208. 2008..Prediction models to identify healthy individuals at high risk of cardiovascular disease have limited accuracy. A low ankle brachial index (ABI) is an indicator of atherosclerosis and has the potential to improve prediction...
- Coronary calcium as a predictor of coronary events in four racial or ethnic groupsRobert Detrano
Department of Radiological Sciences, University of California at Irvine, Irvine, CA 92697, USA
N Engl J Med 358:1336-45. 2008..However, it is not known whether coronary-artery calcium predicts coronary heart disease in other racial or ethnic groups...
- The TIMI risk score for unstable angina/non-ST elevation MI: A method for prognostication and therapeutic decision makingE M Antman
Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
JAMA 284:835-42. 2000..Patients with unstable angina/non-ST-segment elevation myocardial infarction (MI) (UA/NSTEMI) present with a wide spectrum of risk for death and cardiac ischemic events...
- Guidelines on the management of valvular heart disease: The Task Force on the Management of Valvular Heart Disease of the European Society of CardiologyAlec Vahanian
Service de cardiologie, Hôpital Bichat AP HP, Paris, France
Eur Heart J 28:230-68. 2007
- Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2Mary Claire King
Departments of Medicine and Genome Sciences, University of Washington, Seattle, WA 98195, USA
Science 302:643-6. 2003..Lifetime risks of ovarian cancer were 54% for BRCA1 and 23% for BRCA2 mutation carriers. Physical exercise and lack of obesity in adolescence were associated with significantly delayed breast cancer onset...
- Tutorial in biostatistics: competing risks and multi-state modelsH Putter
Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
Stat Med 26:2389-430. 2007..Examples of analysis with standard software are shown...
- European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by rIan Graham
Department of Cardiology, Adelaide and Meath Hospital, Dublin, Ireland
Eur Heart J 28:2375-414. 2007
- Exposure measurement error in time-series studies of air pollution: concepts and consequencesS L Zeger
Johns Hopkins University, School of Public Health, Baltimore, Maryland, USA
Environ Health Perspect 108:419-26. 2000..Finally, we summarize open questions regarding measurement error and suggest the kind of additional data necessary to address them...
- Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)William H Geerts
Thromboembolism Program, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada
Chest 133:381S-453S. 2008..We recommend that, on admission to the ICU, all patients be assessed for their risk of VTE, and that most receive thromboprophylaxis (Grade 1A)...
- Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbationsAlberto Papi
Research Center on Asthma and COPD, Department of Respiratory Diseases, University of Modena and Reggio Emilia, Via del Pozzo 71, I 41100 Modena, Italy
Am J Respir Crit Care Med 173:1114-21. 2006..Severe exacerbations of chronic obstructive pulmonary disease (COPD) are major causes of health care costs mostly related to hospitalization. The role of infections in COPD exacerbations is controversial...
- The relationship between reduced lung function and cardiovascular mortality: a population-based study and a systematic review of the literatureDon D Sin
Department of Medicine, Respiratory Division, University of British Columbia, and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada
Chest 127:1952-9. 2005..We sought to determine the relationship between reduced FEV1 and cardiovascular mortality, independent of smoking...
- Effect of direct-to-consumer genomewide profiling to assess disease riskCinnamon S Bloss
Scripps Genomic Medicine, Scripps Translational Science Institute, and Scripps Health, La Jolla, CA 92037, USA
N Engl J Med 364:524-34. 2011..We examined the psychological, behavioral, and clinical effects of risk scanning with the Navigenics Health Compass, a commercially available test of uncertain clinical validity and utility...
- From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part IMorteza Naghavi
The Center for Vulnerable Plaque Research, University of Texas Houston, The Texas Heart Institute, and President Bush Center for Cardiovascular Health, Memorial Hermann Hospital, Houston, USA
Circulation 108:1664-72. 2003..3) A quantitative method for cumulative risk assessment of vulnerable patients needs to be developed that may include variables based on plaque, blood, and ..
- Derivation and validation of QRISK, a new cardiovascular disease risk score for the United Kingdom: prospective open cohort studyJulia Hippisley-Cox
Tower Building, University Park, Nottingham NG2 7RD
BMJ 335:136. 2007..To derive a new cardiovascular disease risk score (QRISK) for the United Kingdom and to validate its performance against the established Framingham cardiovascular disease algorithm and a newly developed Scottish score (ASSIGN)...
- Current status of cadmium as an environmental health problemLars Jarup
Department of Epidemiology and Public Health, Imperial College London, London, UK
Toxicol Appl Pharmacol 238:201-8. 2009..Therefore, measures should be put in place to reduce exposure to a minimum, and the tolerably daily intake should be set in accordance with recent findings...
- Polygenes, risk prediction, and targeted prevention of breast cancerPaul D P Pharoah
Department of Oncology, University of Cambridge, United Kingdom
N Engl J Med 358:2796-803. 2008..New developments in the search for susceptibility alleles in complex disorders provide support for the possibility of a polygenic approach to the prevention and treatment of common diseases...
- European guidelines on cardiovascular disease prevention in clinical practice: full text. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representIan Graham
Department of Cardiology, The Adelaide and Meath Hospital, Tallaght, Dublin, Ireland
Eur J Cardiovasc Prev Rehabil 14:S1-113. 2007
- Predictive value for the Chinese population of the Framingham CHD risk assessment tool compared with the Chinese Multi-Provincial Cohort StudyJing Liu
Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China
JAMA 291:2591-9. 2004..Recalibration of Framingham functions could permit various regions of the world to adapt Framingham tools to local populations...
- Increasing prevalence of the metabolic syndrome among u.s. AdultsEarl S Ford
Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
Diabetes Care 27:2444-9. 2004..The prevalence of the metabolic syndrome is high among U.S. adults. Our purpose was to determine whether the prevalence of this syndrome has changed since 1988-1994...
- Genetic and clinical predictors for breast cancer risk assessment and stratification among Chinese womenWei Zheng
Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, 2525 West End Avenue, Nashville, TN 37203 1738, USA
J Natl Cancer Inst 102:972-81. 2010..No risk assessment model that incorporates both genetic and clinical predictors is currently available to predict breast cancer ..
- Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causesSteven E Nissen
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
N Engl J Med 356:2457-71. 2007..Rosiglitazone is widely used to treat patients with type 2 diabetes mellitus, but its effect on cardiovascular morbidity and mortality has not been determined...
- Diabetes mellitus and risk of colorectal cancer: a meta-analysisSusanna C Larsson
Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
J Natl Cancer Inst 97:1679-87. 2005..To resolve these inconsistencies, we conducted a meta-analysis of published data on the association between diabetes and the incidence and mortality of colorectal cancer...
- TIMI risk score for ST-elevation myocardial infarction: A convenient, bedside, clinical score for risk assessment at presentation: An intravenous nPA for treatment of infarcting myocardium early II trial substudyD A Morrow
Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Circulation 102:2031-7. 2000..Complex multivariable models identify independent predictors and quantify their relative contribution to mortality risk but are too cumbersome to be readily applied in clinical practice...
- Antithrombotic therapy in atrial fibrillation: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)Daniel E Singer
Clinical Epidemiology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Chest 133:546S-592S. 2008..However, in patients without contraindications to anticoagulation, we suggest beginning IV heparin or LMWH at presentation (Grade 2C)...
- Body mass index, serum sex hormones, and breast cancer risk in postmenopausal womenT J Key
Cancer Research U K Epidemiology Unit, University of Oxford, Gibson Bldg, Radcliffe Infirmary, Oxford OX2 6HE, UK
J Natl Cancer Inst 95:1218-26. 2003..Obesity is associated with increased breast cancer risk among postmenopausal women. We examined whether this association could be explained by the relationship of body mass index (BMI) with serum sex hormone concentrations...
- Carotid-wall intima-media thickness and cardiovascular eventsJoseph F Polak
Department of Radiology, Tufts Medical Center, Boston, MA 02111, USA
N Engl J Med 365:213-21. 2011..Intima-media thickness of the walls of the common carotid artery and internal carotid artery may add to the Framingham risk score for predicting cardiovascular events...
- Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFractureScoresJulia Hippisley-Cox
Division of Primary Care, Tower Building, University Park, Nottingham NG2 7RD
BMJ 339:b4229. 2009..To develop and validate two new fracture risk algorithms (QFractureScores) for estimating the individual risk of osteoporotic fracture or hip fracture over 10 years...
- Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitusPeter W F Wilson
The NHLBI s Framingham Heart Study, Framingham, Massachusetts, USA
Circulation 112:3066-72. 2005..The objective was to investigate risk for CVD, CHD, and T2DM according to metabolic syndrome traits...
- Genome-wide association study of blood pressure and hypertensionDaniel Levy
National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
Nat Genet 41:677-87. 2009..Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension...
- Insulin resistance increases the occurrence of new cardiovascular events in patients with manifest arterial disease without known diabetes. the SMART studySandra N Verhagen
Department of Vascular Medicine, University Medical Centre Utrecht, The Netherlands
Cardiovasc Diabetol 10:100. 2011....
- Interactions between genetic variants and breast cancer risk factors in the breast and prostate cancer cohort consortiumDaniele Campa
Genomic Epidemiology Group, German Cancer Research Center Deutsches Krebsforschungszentrum DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
J Natl Cancer Inst 103:1252-63. 2011..Relatively little is known about the possible interactions between these loci and the established risk factors for breast cancer...
- Gender differences in the metabolic syndrome and their role for cardiovascular diseaseV Regitz-Zagrosek
Center for Gender in Medicine and Cardiovascular Disease in Women, Charite and Deutsches Herzzentrum Berlin, Germany
Clin Res Cardiol 95:136-47. 2006....
- AtherosclerosisA J Lusis
Department of Medicine, Biology Institute, University of California, Los Angeles 90095, USA
Nature 407:233-41. 2000..It is now clear that atherosclerosis is not simply an inevitable degenerative consequence of ageing, but rather a chronic inflammatory condition that can be converted into an acute clinical event by plaque rupture and thrombosis...
- A cohort study of traffic-related air pollution impacts on birth outcomesMichael Brauer
School of Environmental Health, The University of British Columbia, 2206 East Mall, Vancouver BC V6T1Z3 Canada
Environ Health Perspect 116:680-6. 2008..Evidence suggests that air pollution exposure adversely affects pregnancy outcomes. Few studies have examined individual-level intraurban exposure contrasts...
- The use of receiver operating characteristic curves in biomedical informaticsThomas A Lasko
Decision Systems Group, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Biomed Inform 38:404-15. 2005..In this article, we review the basic concepts of ROC analysis, illustrate their use with sample calculations, make recommendations drawn from the literature, and list readily available software...
- A physiological profile approach to falls risk assessment and preventionStephen R Lord
Prince of Wales Medical Research Institute, University of New South Wales, Barker Street, Randwick, New South Wales, 2031, Australia
Phys Ther 83:237-52. 2003The purpose of this perspective article is to describe the use of a physiological profile approach to falls risk assessment and prevention that has been developed by the Falls and Balance Research Group of the Prince of Wales Medical ..
- Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessmentGerald T Ankley
U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, Duluth, Minnesota 55804, USA
Environ Toxicol Chem 29:730-41. 2010..a direct molecular initiating event and an adverse outcome at a biological level of organization relevant to risk assessment. The practical utility of AOPs for ecological risk assessment of chemicals is illustrated using five case ..
- Adherence to Mediterranean diet and health status: meta-analysisFrancesco Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
BMJ 337:a1344. 2008..To systematically review all the prospective cohort studies that have analysed the relation between adherence to a Mediterranean diet, mortality, and incidence of chronic diseases in a primary prevention setting...
- 2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult - 2009 recommendationsJacques Genest
McGill University Health Centre, Montreal, Canada
Can J Cardiol 25:567-79. 2009..The present article represents the 2009 update of the Canadian Cardiovascular Society guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult...
- Balancing the benefits of n-3 polyunsaturated fatty acids and the risks of methylmercury exposure from fish consumptionKathryn R Mahaffey
Department of Occupational and Environmental Health, George Washington University School of Public Health, Washington DC, USA
Nutr Rev 69:493-508. 2011..A framework for providing dietary advice for women of childbearing age on how to maximize the dietary intake of n-3 PUFAs while minimizing MeHg exposures is suggested...
- Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicologyG Oberdorster
Department of Environmental Medicine, University of Rochester, 601 Elmwood Avenue, Medical Center, Rochester, NY 14642, USA
J Intern Med 267:89-105. 2010..Even without being able to perform a quantitative risk assessment for ENMs, due to the lack of sufficient data on exposure, biokinetics and organ toxicity, until we know ..
- Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studiesA Antoniou
Cancer Research U K Genetic Epidemiology Unit, Department of Public Health, University of Cambridge, Cambridge, United Kingdom
Am J Hum Genet 72:1117-30. 2003..The variation in risk by age at diagnosis of index case is consistent with the effects of other genes modifying cancer risk in carriers...
- Pharmaceuticals and personal care products in the environment: what are the big questions?Alistair B A Boxall
Environment Department, University of York, Heslington, York, United Kingdom
Environ Health Perspect 120:1221-9. 2012..Over the past 10-15 years, a substantial amount of work has been done by the scientific, regulatory, and business communities to elucidate the effects and risks of pharmaceuticals and personal care products (PPCPs) in the environment...
- Novel and conventional biomarkers for prediction of incident cardiovascular events in the communityOlle Melander
Department of Clinical Sciences, Lund University, Clinical Research Center, Malmo University Hospital, SE 205 02 Malmo, Sweden
JAMA 302:49-57. 2009Prior studies have demonstrated conflicting results regarding how much information novel biomarkers add to cardiovascular risk assessment.
- Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient airCarl Elis Boström
Swedish Environmental Protection Agency, Stockholm, Sweden
Environ Health Perspect 110:451-88. 2002..Additional source-specific indicators are benzo[ghi]perylene for gasoline vehicles, retene for wood combustion, and dibenzothiophene and benzonaphthothiophene for sulfur-containing fuels...
- Developing risk prediction models for type 2 diabetes: a systematic review of methodology and reportingGary S Collins
Centre for Statistics in Medicine, University of Oxford, Wolfson College Annexe, Oxford, OX2 6UD, UK
BMC Med 9:103. 2011....
- EUROASPIRE III. Management of cardiovascular risk factors in asymptomatic high-risk patients in general practice: cross-sectional survey in 12 European countriesKornelia Kotseva
Department of Cardiovascular Medicine, National Heart and Lung Institute, Imperial College London, London, UK
Eur J Cardiovasc Prev Rehabil 17:530-40. 2010..To determine whether the 2003 Joint European Societies' guidelines on cardiovascular disease prevention in people at high cardiovascular risk have been followed in general practice...
- The association between glucometabolic disturbances, traditional cardiovascular risk factors and self-rated health by age and gender: a cross-sectional analysis within the Malmö Preventive ProjectMargret Leosdottir
Department of Cardiology, Skane University Hospital, and Heart Health Group Department of Clinical Sciences, Lund University, Malmo, Sweden
Cardiovasc Diabetol 10:118. 2011..Whether this age-related reduction applies to CVD risk factors, and whether it is limited to established diabetes mellitus (DM) or also applies to pre-diabetic conditions are not well known...
- Cardiometabolic risk variables in overweight and obese children: a worldwide comparisonMariska van Vliet
Department of Pediatrics, Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands
Cardiovasc Diabetol 10:106. 2011..The results of our review present a fair estimation of the true differences between cardiometabolic risk profiles among pediatric cohorts worldwide, based on available literature...
- Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery diseaseT Heitzer
Universitatsklinikum Hamburg Eppendorf, Klinik und Poliklinik für Innere Medizin, Abteilung Kardiologie, Hamburg, Germany
Circulation 104:2673-8. 2001..This study was designed to determine whether endothelial dysfunction and vascular oxidative stress have prognostic impact on cardiovascular event rates in patients with coronary artery disease...
- Cancer statistics, 2007Ahmedin Jemal
Cancer Occurrence, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA, USA
CA Cancer J Clin 57:43-66. 2007..Further progress can be accelerated by supporting new discoveries and by applying existing cancer control knowledge across all segments of the population...
- Mapping the onset of psychosis: the Comprehensive Assessment of At-Risk Mental StatesAlison R Yung
Department of Psychiatry, University of Melbourne, Melbourne, Australia
Aust N Z J Psychiatry 39:964-71. 2005..This paper describes the pilot evaluation of the CAARMS...
- Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for VasculaJames H Stein
University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
J Am Soc Echocardiogr 21:93-111; quiz 189-90. 2008
- Life course epidemiologyD Kuh
Medical Research Council National Survey of Health and Development, Department of Epidemiology and Public Health, University College London and Royal Free Medical School, Gower Street Campus, 1 19 Torrington Place, London WC1E 6BT, U K
J Epidemiol Community Health 57:778-83. 2003
- Differences in risk factors, atherosclerosis, and cardiovascular disease between ethnic groups in Canada: the Study of Health Assessment and Risk in Ethnic groups (SHARE)S S Anand
Department of Medicine, McMaster University, Ontario, Canada
Lancet 356:279-84. 2000..To establish whether this variation can be explained by differences in disease risk factors and subclinical atherosclerosis, we undertook a population-based study of three ethnic groups in Canada: South Asians, Chinese, and Europeans...
- Meta-analysis of the relationship between risk perception and health behavior: the example of vaccinationNoel T Brewer
Department of Health Behavior and Health Education, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Health Psychol 26:136-45. 2007..Risk perceptions are central to many health behavior theories. However, the relationship between risk perceptions and behavior, muddied by instances of inappropriate assessment and analysis, often looks weak...
- Validation of a modified Early Warning Score in medical admissionsC P Subbe
Department of Medicine, Wrexham Maelor Hospital, Wrexham, UK
QJM 94:521-6. 2001..A clinical pathway could be created, using nurse practitioners and/or critical care physicians, to respond to high scores and intervene with appropriate changes in clinical management...
- Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposureFrederick S vom Saal
Reprod Toxicol 24:131-8. 2007
- Nanotoxicology: an emerging discipline evolving from studies of ultrafine particlesGunter Oberdorster
Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
Environ Health Perspect 113:823-39. 2005..An interdisciplinary team approach (e.g., toxicology, materials science, medicine, molecular biology, and bioinformatics, to name a few) is mandatory for nanotoxicology research to arrive at an appropriate risk assessment.
- Low diagnostic yield of elective coronary angiographyManesh R Patel
Duke Clinical Research Institute, Duke University, Durham, NC 27715, USA
N Engl J Med 362:886-95. 2010Guidelines for triaging patients for cardiac catheterization recommend a risk assessment and noninvasive testing...
- European system for cardiac operative risk evaluation (EuroSCORE)S A Nashef
Papworth Hospital, Cambridge, UK
Eur J Cardiothorac Surg 16:9-13. 1999..To construct a scoring system for the prediction of early mortality in cardiac surgical patients in Europe on the basis of objective risk factors...
- Interactions between chemical and climate stressors: a role for mechanistic toxicology in assessing climate change risksMichael J Hooper
U S Geological Survey, Columbia Environmental Research Center, Columbia, MO, USA
Environ Toxicol Chem 32:32-48. 2013....
- Sedentary behaviors increase risk of cardiovascular disease mortality in menTatiana Y Warren
Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA
Med Sci Sports Exerc 42:879-85. 2010..The purpose of this study was to examine the relationship between two sedentary behaviors (riding in a car and watching TV) and cardiovascular disease (CVD) mortality in men in the Aerobics Center Longitudinal Study...
- Public health importance of triggers of myocardial infarction: a comparative risk assessmentTim S Nawrot
Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium
Lancet 377:732-40. 2011..However, the importance and relevance of each trigger are uncertain. We compared triggers of myocardial infarction at an individual and population level...
- Validation studies of the health improvement network (THIN) database for pharmacoepidemiology researchJames D Lewis
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Pharmacoepidemiol Drug Saf 16:393-401. 2007..We sought to replicate in THIN well-established associations from the medical literature and to compare results from the GPRD practices to the non-GPRD practices within THIN...
- Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk ScorePaul M Ridker
Donald W Reynolds Center for Cardiovascular Research and the Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, MA 02215, USA
JAMA 297:611-9. 2007..Despite improved understanding of atherothrombosis, cardiovascular prediction algorithms for women have largely relied on traditional risk factors...
- Metabolic syndrome vs Framingham Risk Score for prediction of coronary heart disease, stroke, and type 2 diabetes mellitusS Goya Wannamethee
Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, England
Arch Intern Med 165:2644-50. 2005..We sought to compare metabolic syndrome (MetS) with the Framingham Risk Score (FRS) as predictors of coronary heart disease (CHD), stroke, and type 2 diabetes mellitus (DM2) in middle-aged men...
- Risk assessment for vitamin DJohn N Hathcock
Council for Responsible Nutrition, Washington, DC 20036 5114, USA
Am J Clin Nutr 85:6-18. 2007The objective of this review was to apply the risk assessment methodology used by the Food and Nutrition Board (FNB) to derive a revised safe Tolerable Upper Intake Level (UL) for vitamin D...
- Multiple biomarkers for the prediction of first major cardiovascular events and deathThomas J Wang
Framingham Heart Study, Framingham, MA, USA
N Engl J Med 355:2631-9. 2006..Few investigations have evaluated the incremental usefulness of multiple biomarkers from distinct biologic pathways for predicting the risk of cardiovascular events...
- 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?George Davey Smith
University of Bristol, Department of Social Medicine, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
Int J Epidemiol 32:1-22. 2003....
- Treatment with drugs to lower blood pressure and blood cholesterol based on an individual's absolute cardiovascular riskRod Jackson
Section of Epidemiology and Biostatistics, School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
Lancet 365:434-41. 2005..An affordable daily pill combining low doses of various drugs could be useful for the many individuals with slightly abnormal cardiovascular risk factors...
- From disease association to risk assessment: an optimistic view from genome-wide association studies on type 1 diabetesZhi Wei
Department of Computer Science, New Jersey Institute of Technology, Newark, New Jersey, United States of America
PLoS Genet 5:e1000678. 2009..machine-learning approaches with a large ensemble of markers may improve the performance of disease risk assessment. We applied a Support Vector Machine (SVM) algorithm on a GWAS dataset generated on the Affymetrix genotyping ..
- The risks of malaria infection in Kenya in 2009Abdisalan M Noor
Centre for Geographic Medicine, KEMRI University of Oxford, Kenyatta National Hospital Grounds, Nairobi, Kenya
BMC Infect Dis 9:180. 2009..Here we present a new map of malaria risk for Kenya in 2009...
- Time trends and impact of upper and lower gastrointestinal bleeding and perforation in clinical practiceAngel Lanas
Servicio de Aparato Digestivo, Hospital Clinico, Universidad de Zaragoza, Zaragoza, Spain
Am J Gastroenterol 104:1633-41. 2009....
- Prevalence and extent of dyslipidemia and recommended lipid levels in US adults with and without cardiovascular comorbidities: the National Health and Nutrition Examination Survey 2003-2004Heli Ghandehari
Heart Disease Prevention Program, Division of Cardiology, University of California, Irvine, CA 92697, USA
Am Heart J 156:112-9. 2008..We evaluated the proportion of US adults with and without these conditions at (and distance to) recommended levels of LDL-C, non-high-density lipoprotein cholesterol (non-HDL-C), HDL-C, and triglycerides...
- Glycated hemoglobin and associated risk factors in older adultsRaul A Martins
Faculty of Sport Sciences and Physical Education, University of Coimbra, Estádio Universitário, Pavilhão 3, 3040 156 Coimbra, Portugal
Cardiovasc Diabetol 11:13. 2012..Age is associated with several risk factors as increased body fat and abdominal fat, deterioration of the lipid profile, diabetes, raising in inflammatory activity, or decreased functional fitness...
- Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trialFrancis K L Chan
Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
Lancet 376:173-9. 2010..We aimed to compare risk of gastrointestinal events associated with celecoxib versus diclofenac slow release plus omeprazole...
- International variations in hip fracture probabilities: implications for risk assessmentJohn A Kanis
WHO Collaborating Center for Metabolic Bone Diseases, University of Sheffield Medical School, United Kingdom
J Bone Miner Res 17:1237-44. 2002..The categorization of hip fracture probabilities can be used to adjust intervention thresholds based on age, sex, and relative risk from a reference population such as Sweden...
- Renal insufficiency and subsequent death resulting from cardiovascular disease in the United StatesPaul Muntner
Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112, USA
J Am Soc Nephrol 13:745-53. 2002..This study indicates that, in a representative sample of the United States general population, renal insufficiency is independently associated with increased cardiovascular disease-related and all-cause mortality rates...
- Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessmentYan Liu
Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
Environ Health Perspect 118:818-24. 2010..Aflatoxin, a contaminant produced by the fungi Aspergillus flavus and Aspergillus parasiticus in maize and nuts, is a known human liver carcinogen...
- A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analysesSamuli Ripatti
Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland mm fi
Lancet 376:1393-400. 2010..We aimed to establish the external validity of these findings and to obtain more precise risk estimates using a prospective cohort design...
- Infant Screening and Diagnosis of Duchenne Muscular Dys*Paul Fernhoff; Fiscal Year: 2007..These data points will be tracked throughout the project. ..
- Transforming PCI Informed Consent into an Evidence-based Decision-making ToolJohn A Spertus; Fiscal Year: 2010..We will then estimate the cost-savings associated with more rational BAT use to test the hypothesis that PRISM will improve the cost-effectiveness of PCI. ..
- Statins &Lymphoid Malignancy Risk in a Large Multi-Site Population-Based CohortMarianne Ulcickas Yood; Fiscal Year: 2013....
- Routine Aspiration of Residual Gastric Contents in Very Low Birth Weight InfantsLeslie A Parker; Fiscal Year: 2013..Public Health Relevance: This research has potential to influence health policy and practices that may directly translate to improved nutritional and health outcomes for premature VLBW infants. ..
- The Ethics of Fragile X Genetic Screening and Testing Across the LifespanKruti Acharya; Fiscal Year: 2012..The results of the proposed research will be used to develop an R01 application examining the lifetime risks and benefits of carrying a genetic diagnosis for these conditions. ..
- Feasibility, Efficacy, and Mechanisms of Surgical vs Medical Diabetes TreatmentDavid R Flum; Fiscal Year: 2012..abstract_text> ..
- The Physiologic Assessment of Exercise Capacity in Pediatric Sickle Cell AnemiaROBERT IE LIEM; Fiscal Year: 2013....
- Protein intake, nutrition and cardiovascular disease in stage V CKDSrinivasan Beddhu; Fiscal Year: 2011..Relevance to public health: This study will examine in HD patients the role of protein intake in malnutrition and cardiovascular disease, two of the most important problems in these patients. ..
- Toward personalized diabetes care: Understanding hypoglycemia in older adultsKASIA JOANNA LIPSKA; Fiscal Year: 2013..abstract_text> ..
- Safety and Effectiveness Evaluations for DiabetesDONALD READ MILLER; Fiscal Year: 2013..abstract_text> ..
- The Comparative Effectiveness of Single versus Dual Chamber Cardioverter DefibrilPamela N Peterson; Fiscal Year: 2013....
- 2012 Oceans and Human Health Gordon Research Conference and Gordon Research SemiDarrell Jay Grimes; Fiscal Year: 2012....
- Vitamin B12 and Folate in Relation to Cognition in the Framingham Offspring StudyJacob Selhub; Fiscal Year: 2010..5 About 3-5 percent of seniors have low circulating vitamin B12 levels;6 however, about 20 percent of seniors are found to be deficient when those with elevated methylmalonic acid levels are included. ..
- HAART to Prevent HIV Transmission to Infants In BotswanaRoger L Shapiro; Fiscal Year: 2010..The Botswana government has given explicit support for this protocol to occur in four existing Botswana-Harvard AIDS Institute Partnership (BHP) locations to help guide future policy decisions. ..
- Comparative effectiveness of ECG screening in children with Attention Deficit HypLaurel K Leslie; Fiscal Year: 2010..In this application, we propose to apply three up-to-date methodologies - evidence-based synthesis, decision analysis, and preference elicitation - to address this pressing clinical and public policy issue. ..
- Population-Based Assessment of Cancer Trial Generalizability in the ElderlyElizabeth B Lamont; Fiscal Year: 2012....
- Diabetes and Aging in a Multi-Ethnic PopulationAndrew John Karter; Fiscal Year: 2013..abstract_text> ..
- 2/3-Improving Metabolic Parameters of Antipsychotic Child TreatmentLinmarie Sikich; Fiscal Year: 2012..The results of this project will inform future treatment for children and adolescents with major psychiatric disorders. The results are also likely to lead to treatments that improve their health and longevity. ..
- 1/3-Improving Metabolic Parameters of Antipsychotic Child Treatment (IMPACT)Mark A Riddle; Fiscal Year: 2012..The results of this project will inform future treatment for children and adolescents with major psychiatric disorders. The results are also likely to lead to treatments that improve their health and longevity. ..
- 3/3-Improving Metabolic Parameters of Antipsychotic Child Treatment (IMPACT)Christoph U Correll; Fiscal Year: 2012..The results of this project will inform future treatment for children and adolescents with major psychiatric disorders. The results are also likely to lead to treatments that improve their health and longevity. ..
- Chronic Moderate Sleep Restriction in Older Long and Older Average SleepersShawn D Youngstedt; Fiscal Year: 2013..Follow-up assessments will be conducted for 12 months. The proposed clinical trial will provide the most comprehensive Phase 1 assessment of risks and benefits of chronic moderate TIB restriction ever conducted. ..
- Atlases to Report and Correlate Radiotherapy Dose Distributions with OutcomesAndrew Jackson; Fiscal Year: 2013..This should permit the safe delivery of higher biologically effective doses to tumors, resulting in improved local control. ..
- Prolonged Clopidogrel Use After Drug-Eluting and Bare-Metal Coronary StentingScott Kinlay; Fiscal Year: 2013..These data may also inform future randomized trials to address the value of prolonged clopidogrel therapy. ..
- Use and Outcomes of Radiation Therapy for Medicare Patients with Common CancersCary P Gross; Fiscal Year: 2012....
- Risks of Warfarin for Elders with Atrial FibrillationMargaret C Fang; Fiscal Year: 2010..Together, these projects will provide practical experience and form the basis for future studies that seek to improve the safety and use of anticoagulants in the oldest patients with atrial fibrillation. ..
- Optimizing Patient-Oriented Outcomes for Chronic Hepatitis CMai Tuyet Pho; Fiscal Year: 2013..abstract_text> ..
- Drinking Patterns and Post MI Prognosis in WomenMurray A Mittleman; Fiscal Year: 2010..We will also evaluate current trends in drinking behavior among women in the US who have coronary heart disease or are at high risk of developing it. ..
- Communicating Genetic Test Results by Telephone: A Randomized TrialAngela R Bradbury; Fiscal Year: 2013..Given the rising number of available genetic tests, this research has the potential to impact a significant and growing community of patients and their providers seeking genetic risk information to improve their health. ..
- The relationship between pets and multiple child health indicatorsANNE M GADOMSKI; Fiscal Year: 2013..This study will also produce an intervention prototype for primary care providers to use to guide parents in a discussion of the risks and benefits of routine dog ownership for their children. ..
- Pesticide Use & Breast Cancer Risk in Large Cohort of Female Agriculture WorkersLAWRENCE STUART ENGEL; Fiscal Year: 2010..The proposed study will help address these important gaps in our knowledge and help to inform the debate among policy makers and individuals concerning the risks and benefits of these chemicals. ..
- Endocannabinoid Signaling During Early PregnancySudhansu K Dey; Fiscal Year: 2012..abstract_text> ..
- Optimizing HIV Pre-Exposure Prophylaxis through Shared Decision MakingDOUGLAS SCOTT KRAKOWER; Fiscal Year: 2013..The research is significant because it is expected to fundamentally alter clinical decision making for PrEP and other biomedical prevention strategies. ..
- Individualized Interventions to Improve Asthma AdherenceAndrea Apter; Fiscal Year: 2009..We will estimate the incremental cost-effectiveness of PS. ..
- Interaction of Estrogen and Serotonin in Modulating Brain Activation in MenopauseC Neill Epperson; Fiscal Year: 2010..This application is both novel and timely as results from this study are likely to provide information critical to the on-going discussion regarding the risks and benefits of ET use in menopausal women. ..
- A Multicultural, Multilingual HPV Vaccine Education DVD for Diverse PopulationsArmando Valdez; Fiscal Year: 2010....
- Methyl Mercury Effect on Adolescent Development RenewalPhilip W Davidson; Fiscal Year: 2013..The study should also clarify the risks and benefits of fish consumption in relation to neurocognitive and cardiac morbidity that may not become clinically manifest until later in adulthood. ..
- Parent Communication of BRCA1/2 Test Results to ChildrenKENNETH TERCYAK; Fiscal Year: 2009..Findings generated in this area offer a new paradigm within which to view and understand the psychosocial outcomes of predictive testing among tested parents and their nontested children. ..
- Developing and Validating a Veterans Affairs Cardiac Risk ScoreRodney A Hayward; Fiscal Year: 2013....
- Modifiable Disparities in Treatment for Rheumatoid ArthritisDANIEL HAL SOLOMON; Fiscal Year: 2012..abstract_text> ..
- Cognition In Older Breast Cancer Survivors: Treatment Exposure, APOE, &SmokingArti Hurria; Fiscal Year: 2013....
- HPV Vaccine Education Intervention for Medically Underserved High-risk PopulationArmando Valdez; Fiscal Year: 2013..It also leverages our extensive experience with complex, multicultural, multilingual studies to effectively manage the challenges of this multi-audience health literacy study. ..
- Does depression affect quality of decisions to participate in clinical trials?Yan Leykin; Fiscal Year: 2013..Results of this investigation will provide data needed to determine the appropriate level and types of protection and safeguards for depressed individuals enrolling in research. ..
- Comparative Effectiveness of Localized Prostate Cancer Treatments (Pilot Study)Austin B Frakt; Fiscal Year: 2013..Independent variables will include age, co-morbidities, county-level demographics (education, income, provider density), facility quality and VAMC fixed effects. ..
- Advancing HIV Research in Pregnancy;ethics and engagementAnne Drapkin Lyerly; Fiscal Year: 2013....
- The effects of randomized, low-dose hormone therapy on mammographic density in KERulla M Tamimi; Fiscal Year: 2013....
- PREDICTORS OF SPONTANEOUS CEREBRAL AVM HEMORRHAGEHelen Kim; Fiscal Year: 2013..Taken together, there is a pressing need to improve risk assessment. Aim 1 will demonstrate that Silent Intralesional Microhemorrhage (SIM) is a novel risk factor for bAVM ..
- PACTTE-Partnership for Anemia: Clinical and Translational Trials in the ElderlyHarvey Jay Cohen; Fiscal Year: 2012..This Unexplained anemia in the elderly (UAA) can be clinically defined and also shows increased mortality. As the risks or benefits of treatment are completely unknown, UAE is ideally suited for interventional trials. ..
- Vascular Risk Factors and Dementia in the Oldest-OldMaria M Corrada; Fiscal Year: 2013....
- HBV HIV Coinfection Research NetworkRichard Keith Sterling; Fiscal Year: 2013..We will assess the long term renal and bone effects of TDF-based therapy in the HBV-HIV cohort. Collectively, this study will fulfill many of the key priorities outlined in the NIH Action Plan fo Liver Disease for HBV-HIV coinfection. ..
- Contemporary Treatment and Outcomes for Atrial Fibrillation in Clinical PracticeDANIEL EDWIN SINGER; Fiscal Year: 2010....
- Comparative Effectiveness of Treatment Options for Asymptomatic Carotid DiseaseSteven D Pizer; Fiscal Year: 2013..Using a unique national sample of veterans and instrumental variables analysis we will examine the causal relationship between treatment approach and risk-adjusted health outcomes. ..
- Research Training: Complementary &Integrative MedicineGloria Y Yeh; Fiscal Year: 2013....
- Age, functional status, and survival benefit from kidney transplantationPeter Philip Reese; Fiscal Year: 2013....
- Ethical issues in Dementia Research involving Surrogates and Study PartnersBETTY E BLACK; Fiscal Year: 2013....
- Alcohol Use and Relationship Distress in Married CouplesLindsey Rodriguez; Fiscal Year: 2013..Finally, the award will aid in the ethical, methodological, and substantive training of a promising new researcher to address the need for important, innovative research in the domain of drinking and marriage. ..
- Assessing Attitudes and Experiences of Early Adopters of Personalized GenomicsBarbara A Bernhardt; Fiscal Year: 2010..to determine the clinical utility of personalized medicine by offering participants a personalized genomic risk assessment for a variety of diseases and collecting data on health outcomes...
- Alcohol Epidemiological Data System (AEDS)Hsiao ye Yi; Fiscal Year: 2011..The focus of the AEDS contract is secondary data analysis of survey data and collection of secondary survey data for use in scientific reports. ..
- How and Where Methylphenidate Exerts Effect in Adolescent and Adult BrainsNachum Dafny; Fiscal Year: 2013..These data are essential to understand how Ritalin affect the brain and will be beneficial to the ADHD patient and psychostimulant drug abusers in general. ..
- Adolescent Bariatrics: Controlled Longitudinal Study of Psychosocial DevelopmentMARGARET H ZELLER; Fiscal Year: 2012..Hence, the innovative aims and research design of the proposed study will significantly enhance the scientific contribution of the Teen-LABS. ..
- Alcohol Epidemiological Data System (AEDS)Hsiao ye Yi; Fiscal Year: 2009..The focus of the AEDS contract is secondary data analysis of survey data and collection of secondary survey data for use in scientific reports...
- Alcohol Epidemiological Data System (AEDS)Hsiao ye Yi; Fiscal Year: 2012..The focus of the AEDS contract is secondary data analysis of survey data and collection of secondary survey data for use in scientific reports. ..
- Alcohol, Estrogen Replacement Therapy (ERT) and Cognition in Menopausal WomenLaura Tivis; Fiscal Year: 2009..Long- term benefits include an increased understanding of the associations between alcohol consumption and overall health (including cognition), and the influences of specific health-related behaviors. ..
- SUBMACULAR SURGERY TRIALS--PHOTOGRAPH READING CENTERSusan Bressler; Fiscal Year: 2003..BUDGET NOTE: NEI Staff should evaluate the requested budget in light of their experience with the budget needs of reading centers in other clinical trials. ADMINISTRATIVE NOTE: Awards, if made, are limited to 5 years. ..
- ETHICS COURSE SCIENTIST-PARTICIPANT PARTNERSHIPSCelia Fisher; Fiscal Year: 2000....
- ESTROGENS AND VITAMIN A ROLE IN DISEASE PREVENTIONAnnlia Paganini Hill; Fiscal Year: 1991..Extension of these models for use with disease rates and exposure variables that vary continuously with age or time (the proportional hazards model of Cox) will also be used...
- EFFICACY AND SAFETY OF NARCOTICS FOR PEDIATRIC SEDATIONPaul Moore; Fiscal Year: 1990..The use of multiple behavioral assessment scales and multiple physiologic measures will permit a simultaneous evaluation of the sensitivity and reliability available methodologies for determining clinical safety and efficacy...
- Bioactivity and Vitamins in Flash-heated BreastmilkCaroline Chantry; Fiscal Year: 2005..Information from these analyses will be used in linear programming to predict how the described changes in nutrient content of milk due to heating would affect the overall dietary needs of the child and the associated costs. ..
- PRESCRIPTION PATTERNS & PRACT FOR POSTMEMOPAUSAL THERAPYJENNIFER MIGLIONICO; Fiscal Year: 2000..abstract_text> ..
- TS PROPHYLAXIS AND DRUG-RESISTANT MALARIA IN MALAWICHRISTOPHER PLOWE; Fiscal Year: 2007..unreadable] [unreadable]..
- MODERATE ALCOHOL USE--CARDIOVASCULAR RISKS AND BENEFITSThomas Giles; Fiscal Year: 2001..The exacerbation or prevention of EIH will be related to drug effects on the cell-signaling pathway. This research can define the cell-signaling pathway in EIH and provide new and novel approaches to treating EIH. ..
- TAMOXIFEN--RISK OF MI, STROKE AND VENOUS THROMBOEMBOLISMLeslie Bernstein; Fiscal Year: 2001....
- Shared Decision-making in Surgery to Improve Patient Safety and Reduce LiabilityKAREN BARBARA DOMINO; Fiscal Year: 2010..These results will be useful to health systems in making decisions regarding implementation of shared decision-making. ..
- Ethical Issues in Living Donor TransplantationLainie Ross; Fiscal Year: 2009..Part VI provides a methodological consideration of the numerous policy recommendations and revisions that are offered throughout the book to promote the ethical participation of living persons as organ sources. ..
- Cardiovascular Risk Factors and Lifestyle Modification in Breast Cancer SurvivorsWendy Chen; Fiscal Year: 2009....
- End-of-Life Research Ethics: Concerns, Approaches, and ImpactSusan Hickman; Fiscal Year: 2009....