animal care committees
Summary: Institutional committees established to protect the welfare of animals used in research and education. The 1971 NIH Guide for the Care and Use of Laboratory Animals introduced the policy that institutions using warm-blooded animals in projects supported by NIH grants either be accredited by a recognized professional laboratory animal accrediting body or establish its own committee to evaluate animal care; the Public Health Service adopted a policy in 1979 requiring such committees; and the 1985 amendments to the Animal Welfare Act mandate review and approval of federally funded research with animals by a formally designated Institutional Animal Care and Use Committee (IACUC).
Publications223 found, 100 shown here
- Field studies and the IACUC: protocol review, oversight, and occupational health and safety considerationsKathy Laber
Medical University of South Carolina, Charleston, SC 29425, USA
Lab Anim (NY) 36:27-33. 2007..The authors explore many of these challenges, including the special protocol considerations and idiosyncratic occupational health and safety concerns characteristic of field-study reviews...
- New CEO, new IACUC? A word from OLAW and USDAPatricia Brown
Office of Laboratory Animal Welfare, OER, OD, NIH, HHS, USA
Lab Anim (NY) 36:16. 2007
- Grants proposals and animal use protocols: is the IACUC playing by the rules? Instant replay' requiredH Edwin Kennah
Occupational and Environmental Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Lab Anim (NY) 35:16-7. 2006
- Tackling investigator noncompliance: Stop and investigateAnthony McMickle
Arkansas State University Biosciences Institute, Jonesboro, AR, USA
Lab Anim (NY) 35:17. 2006
- Report knocks agriculture department's protection of research animalsJeffrey Brainard
Chron High Educ 52:A27. 2005
- Adoption complications: USDA pain categories do not applyEva B Ryden
Research Animal Facility, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
Lab Anim (NY) 34:19-20. 2005
- Training for best practices for agricultural programsWendy J Underwood
Eli Lily and Company, Lilly Corporate Center, 98 a1105 DC 0417, Indianapolis, IN 46285, USA
Lab Anim (NY) 34:29-32. 2005..The author provides guidance for the development of appropriate training programs for organizations that use agricultural animals in research...
- Decerebrate mammalian preparations: unalleviated or fully alleviated pain? A review and opinionJerald Silverman
Department of Animal Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Contemp Top Lab Anim Sci 44:34-6. 2005..We present a rationale for including decerebrate animals in USDA category D. We also provide a general review of decerebration and suggestions for institutional animal care and use committees having to evaluate decerebration protocols...
- Training the trainee: the institution's responsibility to the often forgottenJoseph N Benoit
The University of North Dakota Graduate School, Grand Forks, ND 58202, USA
Lab Anim (NY) 34:46-50. 2005..The authors draw attention to a common problem facing universities and suggest ways to close the gap in training...
- Is the IACUC interfering with study design? Freedom without accountabilityJames R Owiny
Department of Comparative Medicine, Johns Hopkins University, Baltimore, MD, USA
Lab Anim (NY) 34:18-9. 2005
- When the IACUC and AV don't agree, who wins?: Listen to the AVKaren Cadle
Bioanalytical Systems Inc, West Lafayette, IN, USA
Lab Anim (NY) 34:24. 2005
- When the IACUC and AV don't agree, who wins?: Make the AV part of the planTonja M Henze
Laboratory Animal Facilities, University of Illinois, Urbana, IL, USA
Lab Anim (NY) 34:24. 2005
- When the IACUC and AV don't agree, who wins?: Veterinary variabilityTodd A Jackson
Bristol Myers Squibb s Pharmaceutical Research Institute, Evansville, IN, USA
Lab Anim (NY) 34:23-4. 2005
- Enrichment and nonhuman primates: "first, do no harm"Randall J Nelson
Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA
ILAR J 46:171-7. 2005..These discussions follow the central premise that enrichment should benefit all involved and "First, do no harm."..
- The role of a clinical veterinarian in a safety assessment testing facilityDenise Fillman-Holliday
Department of Laboratory Animal Science at GlaxoSmithKline, 709 Swedeland Rd, King of Prussia, PA 19406, USA
Lab Anim (NY) 34:35-8. 2005....
- Electronic (mis)communication in IACUC procedures. A word from OLAW and USDACarol Wigglesworth
Office of Laboratory Animal Welfare, OER, OD, National Institutes of Health, HHS, Bethesda, MD 20892, USA
Lab Anim (NY) 34:19. 2005
- Protocol audits for post-approval monitoring of animal use protocolsJamie F Smelser
Animal Welfare Program, University of California, San Diego, 9500 Gillman Dr, La Jolla, CA 92093, USA
Lab Anim (NY) 34:23-7. 2005..This program, as well as the protocol audit form they provide, can be used by institutions to initiate, enhance, or evaluate post-approval monitoring programs...
- Grants proposals and animal use protocols: is the IACUC playing by the rules? Modular doesn't applyMichele Cunneen
The AWEN Group Inc, Waltham, MA, USA
Lab Anim (NY) 35:17-8. 2006
- Grants proposals and animal use protocols: is the IACUC playing by the rules? Don't ignore the proposalMichael D Mann
Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA
Lab Anim (NY) 35:17. 2006
- Grants proposals and animal use protocols: is the IACUC playing by the rules? A word from OLAWCarol Wigglesworth
Office of Laboratory Animal Welfare, OER, OD, NIH, HHS
Lab Anim (NY) 35:18. 2006
- Training strategies for IACUC members and the institutional officialM E Greene
Michigan State University, IACUC Office A620 E Fee Hall, East Lansing, MI 48824, USA
ILAR J 48:131-42. 2007..For both the IO and the IACUC, understanding and acceptance of their authority and responsibilities are significant factors in establishing and maintaining a quality animal care and use program...
- Establishing a culture of care, conscience, and responsibility: addressing the improvement of scientific discovery and animal welfare through science-based performance standardsH J Klein
Department of Laboratory Animal Resources, Merck Research Laboratories, Rahway, NJ, USA
ILAR J 48:3-11. 2007....
- Tackling investigator noncompliance: a word from OLAW and USDAPatricia Brown
Lab Anim (NY) 35:18. 2006
- Tackling investigator noncompliance: Decide nowTodd A Jackson
Veterinary Sciences, Bristol Myers Squibb, Pharmaceutical Research Institute, Evansville, IN, USA
Lab Anim (NY) 35:16. 2006
- Tackling investigator noncompliance: Cooperation countsMarc Breedlove
Michigan State University, East Lansing, MI, USA
Lab Anim (NY) 35:16-7. 2006
- Preparation of animals for use in the laboratory: issues and challenges for the Institutional Animal Care and Use Committee (IACUC)Steven A Schapiro
Department of Comparative Medicine, Michale E Keeling Center for Comparative Medicine and Research of The University of Texas M D Anderson Cancer Center, Bastrop, TX, USA
ILAR J 47:370-5. 2006..As empirical data are produced that affect additional aspects of animal care and use, it is important for these committees to be able to evaluate and, when appropriate, stimulate the implementation of improved procedures and strategies...
- Report of the Working Group on Animal Distress in the LaboratoryMarilyn Brown
Charles River Laboratories Foundation, 251 Ballardvale Street, Wilmington, MA 01887, USA
Lab Anim (NY) 35:26-30. 2006....
- Making sense of multiple protocols and grant applications. Room for improvementLara A Weaver
Division of Teaching and Research Resources, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA
Lab Anim (NY) 35:16-7. 2006
- Making sense of multiple protocols and grant applications. Failure of compliance by confusion?Valerie Parkison
Tufts NEMC, Boston, MA, USA
Lab Anim (NY) 35:15-6. 2006
- Collaborative studies and animal reuse: one study, two institutionsBetsy L Bashaw
Animal Resources Facility, Albany Medical College, Albany, NY, USA
Lab Anim (NY) 37:61-2. 2008
- Collaborative studies and animal reuse: a word from OLAW and USDAPatricia Brown
OLAW, OER, OD, NIH, HHS, USA
Lab Anim (NY) 37:63. 2008
- Management of unanticipated outcomes in transgenic mouse facilitiesStacy Pritt
Covance Research Products, Inc, Denver, PA 17517, USA
Lab Anim (NY) 35:27-30. 2006....
- Conference wet lab: is an IACUC needed? Response to protocol review scenario: convene a committeeTamara Goodman-Kuhel
University of Cincinnati, OH, USA
Lab Anim (NY) 35:16. 2006
- Conference wet lab: is an IACUC needed? Response to protocol review scenario: satellite situationAmy J Funk
St Jude Children s Research Hospital, Memphis, TN, USA
Lab Anim (NY) 35:16-7. 2006
- Whistleblower woes: focus on the issueMichele Courtney
Johnson and Johnson Pharmaceutical Research and Development, LLC, San Diego, CA, USA
Lab Anim (NY) 35:16. 2006
- Minimizing harm in agricultural animal experiments in New ZealandM C Morris
Environmental Studies, School of Earth Sciences, Victoria University of Wellington, P O Box 600, Wellington, New Zealand
J Agric Environ Ethics 16:421-37. 2003..Many of these experiments had questionable short-term applications, had an application restricted to agricultural production or economic growth, or could have been modified to prevent or reduce suffering...
- Dealing with IACUC dysfunctionJames G Christenson
Lab Anim (NY) 33:13. 2004
- Clinical blood draws: when do they require IACUC approval?Stacy Pritt
Animal Resources Facility, Joslin Diabetes Center, Boston, MA, USA
Lab Anim (NY) 33:17-21. 2004
- Recognizing and assessing pain, suffering and distress in laboratory animals: a survey of current practice in the UK with recommendationsPenny Hawkins
Research Animals Department, RSPCA, Wilberforce Way, Southwater, West Sussex, RH13 9RS, UK
Lab Anim 36:378-95. 2002..org.uk/pain/(Hawkins 2002). The present paper and the full report, including its recommendations, are intended to provide a source of information, discussion topics and ideas for all establishments that need to monitor animal well-being...
- Reporting noncompliance in the animal facilityVicki Koch
Lab Anim (NY) 32:27. 2003
- A tool for semiannual review of the institutional animal care and use programHolly I McEntee
Research Animal Resources Center, University of Wisconsin Madison, 1710 University Avenue, Madison, WI 53726, USA
Lab Anim (NY) 36:36-40. 2007..The authors present a worksheet that they developed and successfully implemented at their institution, aimed at inspiring an efficient and fruitful discussion of animal care and use...
- Programs for invasive research in North American zoos and aquariumsKaren L Goodrowe
Point Defiance Zoo and Aquarium, Tacoma, WA, USA
ILAR J 44:317-23. 2003..A more standardized approach among zoological institutions for examining and approving research projects that are supported by zoo-based conservation programs would greatly facilitate the wildlife research efforts of North American zoos...
- The refining influence of ethics committees on animal experimentation in SwedenJoakim Hagelin
Department of Physiology, Division of Comparative Medicine, Uppsala University, Box 572, SE 751 23 Uppsala, Sweden
Lab Anim 37:10-8. 2003..In order to have maximal influence on the refinement of scientific protocols it is important that the scientists in the committees are continuously updated on developments in laboratory animal science...
- Knowledge about animal suffering is too rarely usedAndrew N Rowan
Nature 417:587. 2002
- Best practices for animal care committees and animal use oversightW Ron DeHaven
Animal Care Division, US Department of Agriculture s Animal Plant Health Inspection Service, USA
ILAR J 43:S59-62. 2002..These animal care committees (ACCs) are part of an institutional animal welfare team that includes the institutional administration, ..
- Should IACUCs review scientific merit of animal research projects?Michael D Mann
IACUC, Nebraska Medical Center, Omaha, 68198 7830, USA
Lab Anim (NY) 33:26-31. 2004..The authors examine this issue, discuss the pros and cons, suggest how IACUCs can go about reviewing protocols for scientific merit, and question what effect recent changes in regulations will have on this issue...
- Retiring to a chimp paradiseBridget M Kuehn
J Am Vet Med Assoc 222:565-6. 2003
- Opportunistic research and sampling combined with fisheries and wildlife management actions or crisis responseDavid A Jessup
California Department of Fish and Game, Santa Cruz, CA, USA
ILAR J 44:277-85. 2003..Several unique limitations of sample collection situation are described. It is recommended that IACUCs have mechanisms in place to facilitate good research in all of these circumstances...
- Determination of the efficacy of terbinafine hydrochloride nail solution in the topical treatment of dermatophytosis in a guinea pig modelMahmoud A Ghannoum
Center for Medical Mycology, Case Western Reserve University, Cleveland, OH 44106 5028, USA
Mycoses 52:35-43. 2009..Evaluation of the 1%, 5% and 10% TNS in clinical trials for the treatment of dermatophytosis and onychomycosis is warranted...
- Public attitudes in New Zealand towards the use of animals for research, testing and teaching purposesV M Williams
Animal Welfare Group, Biosecurity New Zealand, PO Box 2526, Wellington, New Zealand
N Z Vet J 55:61-8. 2007....
- Factors influencing the effectiveness of research ethics committeesC A Schuppli
Animal Welfare Program, University of British Columbia, 2357 Main Hall, Vancouver, British Columbia, V6T 1Z4, Canada
J Med Ethics 33:294-301. 2007..These results, together with results from the literature on research ethics committees, suggested potential ways to improve the effectiveness of research ethics committees...
- Comparative studies on the topical administration of mucopolysaccharide and heparin ointments in nonhuman primatesDebra A Hoppensteadt
Department of Pathology, Loyola University Chicago, Chicago, Illinois, USA
Clin Appl Thromb Hemost 16:13-20. 2010..In conclusion, MPS showed a stronger release of TFPI than heparin that was not associated with a strong anticoagulant effect. Moreover, MPS downregulated TAFI, resulting in an enhanced fibrinolytic effect...
- Radiofrequency ablation combined with liposomal quercetin to increase tumour destruction by modulation of heat shock protein production in a small animal modelWei Yang
Minimally Invasive Tumor Therapies Laboratory, Department of Radiology, Beth Israel Deaconess Medical Center Harvard Medical School, 1 Deaconess Road, Boston, MA 02215, USA
Int J Hyperthermia 27:527-38. 2011..To investigate the effect of heat shock protein (HSP) modulation on tumour coagulation by combining radiofrequency (RF) ablation with adjuvant liposomal quercetin and/or doxorubicin in a rat tumour model...
- Impact of supra-physiologic retinoids on ovalbumin-sensitized f344 lung tissue and reversal of related pathology by citral - biomed 2011Ibrahim O Farah
University of Mississippi Medical Center, Jackson, Mississippi
Biomed Sci Instrum 47:195-200. 2011..These findings warrants further investigation as to the actual role of these interactions in relation to chronic lung disease and the possibility of reversing retinoid-mediated pathologies in the Fisher rat model...
- Real-time quantitation of renal ischemia using targeted microbubbles: in-vivo measurement of P-selectin expressionSero Andonian
Smith Institute for Urology, North Shore Long Island Jewish Health System, New Hyde Park, New York, USA
J Endourol 23:373-8. 2009..The goal of this project was to use targeted microbubbles outfitted with anti-P-selectin antibodies to quantitate for the first time the microvascular reperfusion injury and regional blood flow in the kidney during IRI...
- Different views on ethics: how animal ethics is situated in a committee cultureM Ideland
Malmo University, Sweden
J Med Ethics 35:258-61. 2009..But committee traditions and priorities of interpretation as well are important to the decisions. The author discusses how "ethics" becomes situated and what implications this may have for committees' decisions...
- Pilot studies of pressure-immobilization bandages for rattlesnake envenomationsWilliam Joel Meggs
Department of Emergency Medicine, Brody School of Medicine, East Carolina University, Greenville, NC, USA
Clin Toxicol (Phila) 48:61-3. 2010..Pilot studies were performed to determine the time of onset of toxicity and efficacy of pressure-immobilizations bandages in a porcine model of rattlesnake envenomation...
- Probiotic acidified formula in an animal model reduces pulmonary and gastric bacterial loadCristiano Boneti
Division of Pediatric Surgery, Department of Surgery, Arkansas Children Hospital, Little Rock, AR 72202, USA
J Pediatr Surg 44:530-3. 2009....
- NOTES: issues and technical details with introduction of NOTES into a small general surgery residency programMichael S Kavic
St Elizabeth Health Center, NEOUCOM for HMHP, Department of Surgery, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44501 1790, USA
JSLS 12:37-45. 2008..The Institutional Animal Care and Use Committee (IACUC) of Northeastern Ohio Universities College of Medicine and Pharmacy (NEOUCOM/COP) approved this study...
- Effects of interleukin-6 ablation on fracture healing in miceAaron Wallace
Penn State Hershey Medical Center, Hershey, Pennsylvania, USA
J Orthop Res 29:1437-42. 2011..110). The absence of IL-6 during early fracture healing significantly reduced osteoclastogenesis and impaired callus strength. By 6 weeks, most histological and biomechanical parameters were similar to fractures in wild-type bone...
- 108 a critical-size craniofacial bone defect model in the yorkshire pigA J Maki
University of Illinois, Urbana
Reprod Fertil Dev 23:159. 2011..This porcine model will allow for the rapid development and testing of new approaches for the repair of damaged bone, which is especially prevalent in the craniofacial area...
- Survey of environmental enhancement programs for laboratory primatesKate C Baker
Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, Louisiana 70433, USA
Am J Primatol 69:377-94. 2007..The data from this survey may be useful for anticipating future program evaluations, establishing more effective internal evaluations, and assessing program progress and resource allocation...
- Expanding the three Rs to meet new challenges in humane animal experimentationCatherine A Schuppli
Animal Welfare Program, Faculty of Agricultural Sciences and W Maurice Young Centre for Applied Ethics, University of British Columbia, 227 6356 Agriculture Road, Vancouver, BC V6T 1Z2, Canada
Altern Lab Anim 32:525-32. 2004..The Three Rs remain very useful, but they require thoughtful interpretation and expansion in order for Animal Ethics Committees to address the full range of issues in animal-based research...
- Neuromuscular effects of stun device dischargesDaniel J Valentino
Cook Country Trauma Unit, Chicago, Illinois, USA
J Surg Res 143:78-87. 2007..To examine this type of electrical injury, we hypothesized that EMI discharges will induce acute or delayed cardiac arrhythmia and neuromuscular injury in an animal model...
- Data and animal management software for large-scale phenotype screeningKeith A Ching
Genomics Institute, Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA
Mamm Genome 17:288-97. 2006..MouseTRACS is available under an open source license at http://www.mousetracs.sourceforge.net...
- Introducing ethical evaluation of the use of animals in experiments in the Near EastSerdar Izmirli
Department of History of Veterinary Medicine and Deontology, Selcuk University, Konya, Turkey
Altern Lab Anim 38:331-6. 2010..The recent establishment of animal ethical review in the Near East could benefit from experiences in Western countries, in their evolution toward high standards of experimental animal ethics...
- Hindlimb unloading rodent model: technical aspectsEmily R Morey-Holton
Life Sciences Division, NASA Ames Research Center, Moffett Field, California 94035 1000, USA
J Appl Physiol (1985) 92:1367-77. 2002..Over 800 references, related to the hindlimb unloading model, can be accessed via the electronic version of this article...
- Immunologic parameters during NOTES compared with laparoscopy in a randomized blinded porcine trialJuliane Bingener
Department of Surgery, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA
Surg Endosc 23:178-81. 2009..We hypothesized that there would be no difference between cytokine levels during NOTES or laparoscopic peritoneoscopy...
- Micro-CT analysis with multiple thresholds allows detection of bone formation and resorption during ultrasound-treated fracture healingTheresa A Freeman
Department of Orthopedic Surgery, Thomas Jefferson University, Curtis Building, Suite 501, 1015 Walnut Street, Philadelphia, Pennsylvania 19107 5099, USA
J Orthop Res 27:673-9. 2009..Results of the study indicate that at sites of bone turnover, this multithresholding analytical technique can be used to provide quantitative information on bone formation, as well as resorption...
- Laboratory guidelines for animal careMarcelo Couto
UCLA School of Medicine DLAM, Los Angeles, CA, USA
Methods Mol Biol 770:579-99. 2011..Guidance is provided regarding the appropriate handling of regulatory noncompliances...
- Blast exposure in rats with body shielding is characterized primarily by diffuse axonal injuryRobert H Garman
Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
J Neurotrauma 28:947-59. 2011..Strikingly, silver staining revealed otherwise undetected abnormalities, and therefore represents a recommended outcome measure in future studies of blast TBI...
- Taser X26 discharges in swine: ventricular rhythm capture is dependent on discharge vectorDaniel J Valentino
Cook County Trauma Unit, John Stroger Hospital of Cook County, Chicago, Illinois 60612, USA
J Trauma 65:1478-85; discussion 1485-7. 2008..We hypothesized that most transcardiac discharge vectors would capture ventricular rhythm, but that other vectors, not traversing the heart, would fail to capture the ventricular rhythm...
- Effect of cage enrichment on the daily use of running wheels by Syrian hamstersStéphan G Reebs
Departement de Biologie, Universite de Moncton, Moncton, NB, Canada
Chronobiol Int 20:9-20. 2003Institutional animal care committees may one day require for the welfare of captive hamsters more floor space and the introduction of tunnels and toys...
- [Global harmonization in the care and use of laboratory animals for the space life science research]K Katahira
Experimental Animal Center, Fukushima Medical University, Fukushima, Japan
Biol Sci Space 15:30-4. 2001..Even if researchers have protocols of the space science in Japan, the animal experiment should be carried out under the global harmonized conditions in accordance with NIH policies and NASA guides...
- Management of rodent viral disease outbreaks: one institutions (r)evolutionAbigail L Smith
Department of Pathobiology, University Laboratory Animal Resources, University of Pennsylvania, 3800 Spruce Street, Suite 177E OVQ, Philadelphia, PA 19104, USA
ILAR J 51:127-37. 2010..This evolution required not only support from the highest levels of leadership in the university and its school of medicine but also a huge outlay of financial resources...
- Determination of sample sizes for demonstrating efficacy of radiation countermeasuresRalph L Kodell
Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Biometrics 66:239-48. 2010....
- Refinement of the use of food and fluid control as motivational tools for macaques used in behavioural neuroscience research: report of a Working Group of the NC3RsMark J Prescott
National Centre for the Replacement, Refinement and Reduction of Animals in Research NC3Rs, 20 Park Crescent, London, UK
J Neurosci Methods 193:167-88. 2010..The report provides a framework for refinement that can be tailored to meet local requirements. It also identifies data gaps and areas for future research and sets out the Working Group's recommendations on contemporary best practice...
- Establishing procedures for institutional oversight of stem cell researchPatricia Zettler
Stanford Law School, Stanford, CA, USA
Acad Med 82:6-10. 2007..The SCRO neither replaces nor duplicates review by the IRB and institutional animal care and use committees. Other AHCs can draw on the UCSF experience when developing their own policies and procedures for stem cell research oversight...
- The survival and function of baboon red blood cells, platelets, and plasma proteins: a review of the experience from 1972 to 2002 at the Naval Blood Research Laboratory, Boston, MassachusettsC Robert Valeri
Naval Blood Research Laboratory, Boston, Massachusetts 02360, USA
Transfusion 46:1S-42S. 2006....
- Invertebrate models for biomedical research, testing, and educationSusan E Wilson-Sanders
University Animal Care, University of Arizona, Tucson, AZ 85724 5092, USA
ILAR J 52:126-52. 2011..The models reviewed can serve as references for scientists, researchers, veterinarians, institutional animal care and use committees (IACUCs), and others interested in alternatives to vertebrate animals...
- Metastatic human colonic carcinoma: molecular imaging with pretargeted SPECT and PET in a mouse modelRobert M Sharkey
Center for Molecular Medicine and Immunology, Garden State Cancer Center, 520 Belleville Ave, Belleville, NJ 07109, USA
Radiology 246:497-507. 2008..To prospectively determine if a bispecific monoclonal antibody (MoAb) pretargeting method with a radiolabeled hapten peptide can depict small (<0.3 mm in diameter) microdisseminated human colon cancer colonies in the lungs of nude mice...
- A renewed look at laboratory rodent housing and managementJanet C Gonder
Garber Consulting LLC, Pinehurst, NC, USA
ILAR J 48:29-36. 2007..This new information is provided to aid IACUCs and facility managers in making decisions regarding the housing and care of laboratory rodents...
- IACUC Challenges in Invertebrate ResearchChris Harvey-Clark
Animal Care Centre, University of British Columbia, Vancouver, Canada
ILAR J 52:213-20. 2011....
- Inhibition of C5 or absence of C6 protects from sepsis mortalityJon A Buras
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Immunobiology 209:629-35. 2004..Inhibition of the complement MAC does not increase bacterial load or mortality, therefore, the use of anti-C5 therapy may be beneficial rather than detrimental in sepsis...
- Computed tomographic validation of the porcine model for thoracic scoliosisAshish Patel
Department of Orthopaedics, NYU Hospital for Joint Diseases, New York, NY 10010, USA
Spine (Phila Pa 1976) 35:18-25. 2010..Computed Tomographic Analysis of the Porcine Scoliosis Model...
- Degenerative changes following spinal fixation in a small animal modelGregory D Cramer
Department of Research, National University of Health Sciences, 200 E Roosevelt Road, Lombard, IL 60148, USA
J Manipulative Physiol Ther 27:141-54. 2004..The objective of this study was to evaluate changes of the lumbar vertebral column following fixation...
- Novel endoscopic application of a new flexible-fiber CO2 laser for esophageal mucosal ablation in a porcine modelS Anandasabapathy
Division of Gastroenterology, M D Anderson Cancer Center, Houston, Texas, USA
Endoscopy 41:138-42. 2009..The aim of the current study was to evaluate the performance, efficacy, and safety of a novel, photonic band-gap CO (2) laser configured for esophageal mucosal ablation...
- Apoptotic cells, autoantibodies, and the role of HMGB1 in the subcellular localization of an autoantigenAmy N Sanford
Division of Allergy and Immunology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Autoimmun 25:264-71. 2005..This is the first description of an inflammatory stimulus altering the immunologic availability of a potential autoantigen...
- Multimedia article: Transvaginal laparoscopic cholecystectomy: laparoscopically assistedMarc Bessler
Department of Surgery, Columbia University College of Physicians and Surgeons, 161 Fort Washington Avenue, Suite 620, New York, NY 10032, USA
Surg Endosc 22:1715-6. 2008..Total operative time ranged between 110 and 155 min. Based on our experience in the porcine model, we believe that a transvaginal endoscopic cholecystectomy is feasible in humans...
- A comprehensive laboratory animal facility pandemic response planGordon S Roble
Tri Institutional Training Program in Laboratory Animal Medicine and Science, New York, New York, USA
J Am Assoc Lab Anim Sci 49:623-32. 2010..Elements of this plan were put into practice after escalation of the pandemic alerts due to influenza A (H1N1) in April 2009...
- Assessing the search for and implementation of the Three Rs: a survey among scientistsMarlies Leenaars
Radboud University Nijmegen Medical Centre, Central Animal Laboratory, Nijmegen, The Netherlands
Altern Lab Anim 37:297-303. 2009....
- Effects of hydroxyapatite on titanium foam as a bone ingrowth surface in acetabular shells: a canine studyWilliam M Mihalko
University of Tennessee, InMotion Orthopaedic Research Center, Campbell Clinic Orthopaedics, Memphis, TN 38017, USA
J Long Term Eff Med Implants 20:35-42. 2010..The results prove not only that titanium foam is a viable ingrowth surface but also that PA coating can enhance the time to bony incorporation...
- The AALAS Learning Library and its effectiveness as a tool for technician trainingJan Parker-Thornburg
M D Anderson Cancer Center, Department of Biochemistry and Molecular Biology, Houston, TX, USA
Lab Anim (NY) 38:195-201. 2009..They also correlated ALL usage with pass rates in technician certification exams. Results suggest that the ALL is a highly effective method of training, particularly for technician certification...
- A guide to defining and implementing protocols for the welfare assessment of laboratory animals: eleventh report of the BVAAWF/FRAME/RSPCA/UFAW Joint Working Group on RefinementP Hawkins
Research Animals Department, RSPCA, Wilberforce Way, Southwater, West Sussex RH13 9RS, UK
Lab Anim 45:1-13. 2011..A longer version of this document, with further background information and extra topics including training and information sharing, is available on the Laboratory Animals website...
- A new high frequency microultrasound system with applications in cardiovascular researchF Stuart Foster
Sunnybrook Health Sci Ctr, Univ of Toronto, 2075 Bayview Ave, and VisualSonics Inc, 3080 Yonge St, Toronto, Canada
J Acoust Soc Am 125:2712. 2009..All experiments with animals were done under a protocol approved by the Sunnybrook or VisualSonics Animal Care Committees. [The author declares a significant financial interest in VisualSonics Inc.].
- Animal models of substance abuse and addiction: implications for science, animal welfare, and societyWendy J Lynch
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia, USA
Comp Med 60:177-88. 2010....
- A porcine model for progressive thoracic scoliosisFrank Schwab
New York University Hospital for Joint Diseases, New York, NY, USA
Spine (Phila Pa 1976) 34:E397-404. 2009..An IACUC-approved study to create a scoliotic deformity representative of adolescent idiopathic scoliosis...
- [Animal experiment ethics committee of Showa University]Norimitsu Kurata
Nihon Yakurigaku Zasshi 129:24-30. 2007
- Postop monitoring: on the record? Compromise is in orderDavid M Kurtz
Experimental Pathology Laboratories, Inc, US Environmental Protection Agency, Research Triangle Park, NC, USA
Lab Anim (NY) 34:15-6. 2005
- Response to protocol review scenario: SOPs for hypothermiaAnn Marie Dinkel
Delaware Technical and Community College, Georgetown, DE, USA
Lab Anim (NY) 37:106. 2008
- Questioning IACUC composition: is SOCRATES' reasoning correct? Every IACUC can improveLida Anestidou
Center for Clinical and Research Ethics, Vanderbilt University Medical Center, Nashville, TN, USA
Lab Anim (NY) 34:19-20. 2005
- Ghrelin: Behavioral, Anatomical, and Physiological Components of ObesityBRETT JOHN WARREN TEUBNER; Fiscal Year: 2011....
- Improving Air Quality for Laboratory Animal ResearchSharron S Quisenberry; Fiscal Year: 2010..A Project Liaison Officer will assist with communications and coordination among the key scientists and other Key Personnel. ..
- Fc receptor targeted therapy for immune hemolytic anemiaPeriasamy Selvaraj; Fiscal Year: 2009..Project Description Page 6 ..
- Restoration of Fecal Continence in Aging IASKhalil N Bitar; Fiscal Year: 2012..Project Description Page 6 ..
- Transcriptional Regulation of Retinal DevelopmentMengqing Xiang; Fiscal Year: 2012..The proposed studies together are expected to provide important insights into the genetic regulatory networks involved in retinal cell diversification and differentiation. Project Description Page 6 ..
- Renovations of the Animal Care FacilityAWADH AMIR BINHAZIM; Fiscal Year: 2010..This 32% increase in the number of research protocols in the ACF taxes the limited resources of the ACF, and the improvements described in this application are designed to accommodate the needs of Meharry investigators more fully. ..
- Anesthesiology &Perioperative Medicine Research TrainingTonya M Palermo; Fiscal Year: 2013..With the aging population, developing physician scientists capable of tackling scientific questions in this important arena of medicine should make care of surgery, trauma, and intensive care patients safer...
- Caliper Life Sciences IVIS Lumina II imaging systemBrad T Cookson; Fiscal Year: 2012..Thus, important diagnostic and potentially therapeutic information about important problems such as cancer, infection and autoimmune diseases will be provided from the studies in this application. ..
- Jefferson Alumni Hall Modernization of Cage Sanitation FacilityJudith S Daviau; Fiscal Year: 2013..The procurement and installation of this equipment will result in increased personnel efficiency, less down time, significant operational savings and decreased negative environmental impact. ..
- Remediation of Word Processing and Short-Term Memory Deficits in AphasiaNadine Martin; Fiscal Year: 2009..The efficacy of the treatment will be examined with probes of acquisition and maintenance in a multiple baseline across multiple stimuli design, and with comparisons of pre- and post-test ..
- Translational Research and Laboratory Animal Medicine Education for VeterinariansDiane J Gaertner; Fiscal Year: 2013....
- Cagewash Renovation for Safety &Long-Term Research Support at The Salk InstituteJON DAVID REUTER; Fiscal Year: 2013..Funds will allow us to reallocate recharge resources to continue refurbishing older units and maintain IACUC compliance and AAALAC accreditation standards. ..
- DRUG ABUSE RESEARCH TRAINING PROGRAMNancy K Mello; Fiscal Year: 2011....
- NEUROPEPTIDE REGULATION OF ENTEROPANCREATIC FUNCTIONMichael W Mulholland; Fiscal Year: 2013..It houses on average 10,000 mice, 400 hamsters, and 8 rabbits. The facility is inspected annually by USDA, and bi-annually by UCSF/IACUC. ..
- Urethral Catheter to Measure Distributed Occlusive Pressures and Sphincter EMGRajesh Rajamani; Fiscal Year: 2013..The research team for the project includes engineering experts in sensor design and fabrication, surgeons in urology and a professor in urology who has co-founded leading urologic device companies. ..
- CORE A: ADMINISTRATIVE COREPatrick M Gaffney; Fiscal Year: 2011..abstract_text> ..
- Treating EAE disease with Fc-DimersDavid M Mosser; Fiscal Year: 2013..The goal of these studies is to demonstrate (for the first time) that a therapeutic directed at reprogramming macrophages has the potential to treat autoimmune diseases. ..
- Development of Bimanual Coordination of Early ChildhoodKAREN E BRAKKE; Fiscal Year: 2010..Additionally, it will provide research-training opportunities for several students who are under-represented minority women. Project Description Page 6 ..
- Movable Equipment for DDB Animal FacilityMARVIN MICHAEL SWINDLE; Fiscal Year: 2010..Maintaining an SPF environment and remaining in compliance with current and future standards of laboratory animal care and use demand the highest achievable standards of disinfection, decontamination and occupational safety. ..
- Animal Resource Improvement at the University of Notre DameMark A Suckow; Fiscal Year: 2012..Further, the proposed upgrade will address animal health issues and optimize our ability to provide continuous monitoring of, and response for, environmental parameters key to a successful research enterprise. ..
- Parvin Building Animal Resources Center Improvement PlanRichard W Ermel; Fiscal Year: 2013..5M) active and 122 ($35.3M) pending projects involving animal model research, and will help to ensure COH/BRI continues its remarkable history of innovation and achievements in science and medical care. ..
- Developing an Office of Sponsored Projects for Presbyterian CollegeSarah M Sweitzer; Fiscal Year: 2013....
- ILAR JOURNALFRANCES E SHARPLES; Fiscal Year: 2010..5. To widely disseminate information on laboratory animal care and use by providing a publication at low cost to all members of the international and US biomedical communities. ..
- Training Clinical Veterinarians in Nonhuman Primate Clinical MedicineJanice D Wagner; Fiscal Year: 2010..D. Anderson Cancer Research Center at Bastrop (for experience with chimpanzees and neotropical primates) are also included. ..
- Investigators and IACUCs: integrity in animal researchCharles W Lidz; Fiscal Year: 2011..The proposed research is a first step in a research path that can produce policy and administrative recommendations that will facilitate effective and efficient functioning of IACUCs and thus animal research. ..
- GENETIC COMPETENCE APPARATUS OF BACILLUS SUBTILISDAVID A DUBNAU; Fiscal Year: 2013..b. If yes, identify countries: Germany 5.c. Optional Explanation: Collaboration with Dr. Berenike Maier 6. * Project Summary/Abstract 2297-summary.pdf Mime Type: application/pdf 7. * ..
- Live Cell Imaging Confocal Microscope SystemJeffrey Shawn Goodwin; Fiscal Year: 2010....
- Signaling in Tissue Injury and RepairRobert Diegelmann; Fiscal Year: 2009..The Program Director has made concerted efforts and will continue to strive to attract underrepresented minorities to apply to this unique training program. ..
- Human Subjects Research Enhancement ProgramStephen Slogoff; Fiscal Year: 2002..Two computers, a laptop and a video camera are the only requirements for this enhancement. ..
- Prolonged Analgesia in RodentsJames Johnson; Fiscal Year: 2007..If this formulation is successful, it could be used for other laboratory animals with appropriate dose adjustment. [unreadable] [unreadable] [unreadable]..
- Primate Veterinarian Training at the WaNPRCCharlotte Hotchkiss; Fiscal Year: 2009..abstract_text> ..
- A Broadly Accessible Virtual Reading TutorRONALD COLE; Fiscal Year: 2009..In addition, using speech recognition technology to measure the ..
- Development and Improvement of an Animal Resource CoreDale Bredesen; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCESTIMOTHY POOLE; Fiscal Year: 1992..2. Resurfacing of Cage Wash Area Floors-Due to the heavy and harsh use of this area, the floor surface has deteriorated to such an extent that efficient cleaning and sanitation is difficult...
- IMPROVING ANIMAL RESOURCES AT THE MI BASSETT HOSPITALRoberta Reed; Fiscal Year: 1991..With the completion of the proposed alterations and renovations to the farm facility, the entire animal facility and program would be accreditable by AAALAC...
- ALTERATIONS AND RENOVATIONS - UNIVERSITY OF UTAH ARCJack Taylor; Fiscal Year: 1991..The Animal Resources program and its facilities should adequately support, now and in the future, the biomedical research of the University and its contributions to the health and well-being of mankind...
- RESEARCH TRAINING IN BLOOD AND VASCULAR BIOLOGYSandor Shapiro; Fiscal Year: 1999..In addition, resources of the Cardeza Foundation library and conference room, medical illustration unit, clinical laboratory, and administrative facilities and personnel will be available for support of this training grant. ..
- Improving Institutional Animal Resources at MUSCMARVIN SWINDLE; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCESJoseph Wagner; Fiscal Year: 1991..Completion of this project will enable the UM to proceed with AAALAC accreditation...
- Fixed Equipment for DDB Animal ResourceMARVIN SWINDLE; Fiscal Year: 2009..The requested equipment will provide protection against the spread of complicating rodent diseases in the facilities. ..
- ANIMAL RESOURCE FACILITY RENOVATION/CENTRALIZATIONChristian Abee; Fiscal Year: 1991..Completion of this phase of the university's plan will also allow us to seek university-wide AAALAC accreditation...
- ANIMAL FACILITY IMPROVEMENTJERRY STINNER; Fiscal Year: 1993..Achievement of AAALAC-accreditation will be facilitated if we upgrade our new facility with the equipment requested...
- Facility renovation to expand mouse barrier spaceLINDA TOTH; Fiscal Year: 2005..This space will not be adequate to support our anticipated continued growth in the areas of infectious disease and toxic challenge and in the need for quarantine of non-vendor rodents. ..
- ANIMAL FACILITY IMPROVEMENTS FOR SMALL RESEARCH PROGRAMSGENE SCALARONE; Fiscal Year: 1992..This proposal is for a single modern cage washing system to fully complement recent renovations and provide automated cage washing at a level of quality consistent with AAALAC standards...
- CAGE WASHER REPLACEMENT AND RELATED RENOVATIONDavid Bernstein; Fiscal Year: 1992..Alterations and renovations include electric, plumbing and exhaust...
- ANIMAL RESOURCES IMPROVEMENTALEXANDER LUCAS; Fiscal Year: 1990..These modifications to the CHORI ARF will promote good animal husbandry practices and thus improve animal health and facilities management...
- DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCESSeymour Lieberman; Fiscal Year: 1990..Now in it's third year, projections indicate that financial assistance from outside sources will be needed to complete planned facility renovations...
- DEVELOPING & IMPROVING INSTITUTIONAL ANIMAL RESOURCESMACK SCOTT; Fiscal Year: 1990..The improvement proposed in this application will benefit all users of ACF and insure that the facility complies with federal regulations...
- IMPROVING INSTITUTIONAL ANIMAL RESOURCESMARVIN SWINDLE; Fiscal Year: 2003....
- ANIMAL FACILITIES IMPROVEMENTRONALD MARKLE; Fiscal Year: 1990..With acquisition of the same, thorough, consistent cleaning and sterilization of animal cages and ancillary items can be met in a fashion that maximizes animal health, personnel safety and efficiency...
- ABSL2/3 EQUIPMENTWilliam Morton; Fiscal Year: 2003....
- GENETOXICITY STUDIES OF CHEMOPREDVENTIVE AGENTS - TASK AKristien Mortelmans; Fiscal Year: 2000....
- ANIMAL HEALTH RESOURCES IMPROVEMENT PROJECTLeland Hartwell; Fiscal Year: 2004....
- AN IMPROVED ANIMAL RESOURCE FACILITIESAnn Henderson; Fiscal Year: 2004..Further, it will allow us to maintain our outstanding record in mentoring underserved populations in science. ..
- ANIMAL FACILITY RENOVATIONLee Cera; Fiscal Year: 2003..It will also permit the complete initiation of barrier policies and limit mixing of clean and contaminated cages and racks. This faculty as well as members of the IACUC participated in the development of these plans. ..
- ANIMAL FACILITY IMPROVEMENTNorman Paradise; Fiscal Year: 1992..The new ARC, together with the equipment requested in this proposal, will promote significant improvements in animal use and care and substantially enhance The University of Akron's biomedical research programs...
- DEVELOPING & IMPROVING ANIMAL RESOURCESMark Batshaw; Fiscal Year: 2002..abstract_text> ..
- ANIMAL RESOURCE IMPROVEMENTCHARLES RAFLO; Fiscal Year: 1993..The computer will also be used for the computerized animal accounting system (GCS) and protocol data base. These changes will significantly enhance the animal care and use program at the University of Houston...
- DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCESLouis De Tolla; Fiscal Year: 1991..With NIH grant support we can rectify current inadequacies and begin to meet the needs of an increasing animal census...
- IMPROVING INSTITUTIONAL ANIMAL RESOURCESLAURETTA GERRITY; Fiscal Year: 2003....
- ADMINISTRATORS OF THE TULANE EDUCATIONAndrew Lackner; Fiscal Year: 2003..The enhanced facility will also provide support space for the training programs for both veterinary residents in nonhuman primate medicine and in support of IACUC mandated personnel training. ..
- RANGE FINDING/ACUTE ORAL TOXICITY OF CHEMOPREVENTIVESMALCOLM BLAIR; Fiscal Year: 2000....