animal care committees
Summary: Institutional committees established to protect the welfare of animals used in research and education. The 1971 NIH Guide for the Care and Use of Laboratory Animals introduced the policy that institutions using warm-blooded animals in projects supported by NIH grants either be accredited by a recognized professional laboratory animal accrediting body or establish its own committee to evaluate animal care; the Public Health Service adopted a policy in 1979 requiring such committees; and the 1985 amendments to the Animal Welfare Act mandate review and approval of federally funded research with animals by a formally designated Institutional Animal Care and Use Committee (IACUC).
Publications188 found, 100 shown here
- Field studies and the IACUC: protocol review, oversight, and occupational health and safety considerationsKathy Laber
Medical University of South Carolina, Charleston, SC 29425, USA
Lab Anim (NY) 36:27-33. 2007..The authors explore many of these challenges, including the special protocol considerations and idiosyncratic occupational health and safety concerns characteristic of field-study reviews...
- Collaborative studies and animal reuse: a word from OLAW and USDAPatricia Brown
OLAW, OER, OD, NIH, HHS, USA
Lab Anim (NY) 37:63. 2008
- Grants proposals and animal use protocols: is the IACUC playing by the rules? A word from OLAWCarol Wigglesworth
Office of Laboratory Animal Welfare, OER, OD, NIH, HHS
Lab Anim (NY) 35:18. 2006
- Grants proposals and animal use protocols: is the IACUC playing by the rules? Don't ignore the proposalMichael D Mann
Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA
Lab Anim (NY) 35:17. 2006
- Grants proposals and animal use protocols: is the IACUC playing by the rules? Modular doesn't applyMichele Cunneen
The AWEN Group Inc, Waltham, MA, USA
Lab Anim (NY) 35:17-8. 2006
- Grants proposals and animal use protocols: is the IACUC playing by the rules? Instant replay' requiredH Edwin Kennah
Occupational and Environmental Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Lab Anim (NY) 35:16-7. 2006
- Report knocks agriculture department's protection of research animalsJeffrey Brainard
Chron High Educ 52:A27. 2005
- Protocol audits for post-approval monitoring of animal use protocolsJamie F Smelser
Animal Welfare Program, University of California, San Diego, 9500 Gillman Dr, La Jolla, CA 92093, USA
Lab Anim (NY) 34:23-7. 2005..This program, as well as the protocol audit form they provide, can be used by institutions to initiate, enhance, or evaluate post-approval monitoring programs...
- Adoption complications: The answer is 'C'Jori Leszczynski
Cleveland Clinic Foundation, Cleveland, OH, USA
Lab Anim (NY) 34:20. 2005
- Adoption complications: USDA pain categories do not applyEva B Ryden
Research Animal Facility, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
Lab Anim (NY) 34:19-20. 2005
- Training for best practices for agricultural programsWendy J Underwood
Eli Lily and Company, Lilly Corporate Center, 98 a1105 DC 0417, Indianapolis, IN 46285, USA
Lab Anim (NY) 34:29-32. 2005..The author provides guidance for the development of appropriate training programs for organizations that use agricultural animals in research...
- Decerebrate mammalian preparations: unalleviated or fully alleviated pain? A review and opinionJerald Silverman
Department of Animal Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Contemp Top Lab Anim Sci 44:34-6. 2005..We present a rationale for including decerebrate animals in USDA category D. We also provide a general review of decerebration and suggestions for institutional animal care and use committees having to evaluate decerebration protocols...
- Training the trainee: the institution's responsibility to the often forgottenJoseph N Benoit
The University of North Dakota Graduate School, Grand Forks, ND 58202, USA
Lab Anim (NY) 34:46-50. 2005..The authors draw attention to a common problem facing universities and suggest ways to close the gap in training...
- Is the IACUC interfering with study design? Freedom without accountabilityJames R Owiny
Department of Comparative Medicine, Johns Hopkins University, Baltimore, MD, USA
Lab Anim (NY) 34:18-9. 2005
- When the IACUC and AV don't agree, who wins?: Listen to the AVKaren Cadle
Bioanalytical Systems Inc, West Lafayette, IN, USA
Lab Anim (NY) 34:24. 2005
- When the IACUC and AV don't agree, who wins?: Make the AV part of the planTonja M Henze
Laboratory Animal Facilities, University of Illinois, Urbana, IL, USA
Lab Anim (NY) 34:24. 2005
- When the IACUC and AV don't agree, who wins?: Veterinary variabilityTodd A Jackson
Bristol Myers Squibb s Pharmaceutical Research Institute, Evansville, IN, USA
Lab Anim (NY) 34:23-4. 2005
- Enrichment and nonhuman primates: "first, do no harm"Randall J Nelson
Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA
ILAR J 46:171-7. 2005..These discussions follow the central premise that enrichment should benefit all involved and "First, do no harm."..
- The role of a clinical veterinarian in a safety assessment testing facilityDenise Fillman-Holliday
Department of Laboratory Animal Science at GlaxoSmithKline, 709 Swedeland Rd, King of Prussia, PA 19406, USA
Lab Anim (NY) 34:35-8. 2005....
- Whistleblower woes: focus on the issueMichele Courtney
Johnson and Johnson Pharmaceutical Research and Development, LLC, San Diego, CA, USA
Lab Anim (NY) 35:16. 2006
- Conference wet lab: is an IACUC needed? Response to protocol review scenario: satellite situationAmy J Funk
St Jude Children s Research Hospital, Memphis, TN, USA
Lab Anim (NY) 35:16-7. 2006
- Conference wet lab: is an IACUC needed? Response to protocol review scenario: convene a committeeTamara Goodman-Kuhel
University of Cincinnati, OH, USA
Lab Anim (NY) 35:16. 2006
- Collaborative studies and animal reuse: inter-related, not just relatedKathryn Nepote
Maryland Department of Agriculture, Animal Health Diagnostic Laboratory, College Park, MD, USA
Lab Anim (NY) 37:62. 2008
- Collaborative studies and animal reuse: one study, two institutionsBetsy L Bashaw
Animal Resources Facility, Albany Medical College, Albany, NY, USA
Lab Anim (NY) 37:61-2. 2008
- Should clinical complications affect USDA pain categories? Concur with CovelliLisa Portnoy
National Institutes of Health s Clinical Center, Bethesda, MD, USA
Lab Anim (NY) 36:13-4. 2007
- A tool for semiannual review of the institutional animal care and use programHolly I McEntee
Research Animal Resources Center, University of Wisconsin Madison, 1710 University Avenue, Madison, WI 53726, USA
Lab Anim (NY) 36:36-40. 2007..The authors present a worksheet that they developed and successfully implemented at their institution, aimed at inspiring an efficient and fruitful discussion of animal care and use...
- Training strategies for IACUC members and the institutional officialM E Greene
Michigan State University, IACUC Office A620 E Fee Hall, East Lansing, MI 48824, USA
ILAR J 48:131-42. 2007..For both the IO and the IACUC, understanding and acceptance of their authority and responsibilities are significant factors in establishing and maintaining a quality animal care and use program...
- New CEO, new IACUC? New policy may be in orderStephen M Dempsey
North Carolina State University, Raleigh, NC, USA
Lab Anim (NY) 36:16-7. 2007
- New CEO, new IACUC? A word from OLAW and USDAPatricia Brown
Office of Laboratory Animal Welfare, OER, OD, NIH, HHS, USA
Lab Anim (NY) 36:16. 2007
- Establishing a culture of care, conscience, and responsibility: addressing the improvement of scientific discovery and animal welfare through science-based performance standardsH J Klein
Department of Laboratory Animal Resources, Merck Research Laboratories, Rahway, NJ, USA
ILAR J 48:3-11. 2007....
- Tackling investigator noncompliance: a word from OLAW and USDAPatricia Brown
Lab Anim (NY) 35:18. 2006
- Tackling investigator noncompliance: Stop and investigateAnthony McMickle
Arkansas State University Biosciences Institute, Jonesboro, AR, USA
Lab Anim (NY) 35:17. 2006
- Tackling investigator noncompliance: Decide nowTodd A Jackson
Veterinary Sciences, Bristol Myers Squibb, Pharmaceutical Research Institute, Evansville, IN, USA
Lab Anim (NY) 35:16. 2006
- Tackling investigator noncompliance: Cooperation countsMarc Breedlove
Michigan State University, East Lansing, MI, USA
Lab Anim (NY) 35:16-7. 2006
- Preparation of animals for use in the laboratory: issues and challenges for the Institutional Animal Care and Use Committee (IACUC)Steven A Schapiro
Department of Comparative Medicine, Michale E Keeling Center for Comparative Medicine and Research of The University of Texas M D Anderson Cancer Center, Bastrop, TX, USA
ILAR J 47:370-5. 2006..As empirical data are produced that affect additional aspects of animal care and use, it is important for these committees to be able to evaluate and, when appropriate, stimulate the implementation of improved procedures and strategies...
- Report of the Working Group on Animal Distress in the LaboratoryMarilyn Brown
Charles River Laboratories Foundation, 251 Ballardvale Street, Wilmington, MA 01887, USA
Lab Anim (NY) 35:26-30. 2006....
- Making sense of multiple protocols and grant applications. Room for improvementLara A Weaver
Division of Teaching and Research Resources, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA
Lab Anim (NY) 35:16-7. 2006
- Making sense of multiple protocols and grant applications. Failure of compliance by confusion?Valerie Parkison
Tufts NEMC, Boston, MA, USA
Lab Anim (NY) 35:15-6. 2006
- Management of unanticipated outcomes in transgenic mouse facilitiesStacy Pritt
Covance Research Products, Inc, Denver, PA 17517, USA
Lab Anim (NY) 35:27-30. 2006....
- Electronic (mis)communication in IACUC procedures. A word from OLAW and USDACarol Wigglesworth
Office of Laboratory Animal Welfare, OER, OD, National Institutes of Health, HHS, Bethesda, MD 20892, USA
Lab Anim (NY) 34:19. 2005
- Surgical implantation of transmitters into fishDaniel M Mulcahy
US Geological Survey s Alaska Science Center, Anchorage, AK, USA
ILAR J 44:295-306. 2003..Exceptions to surgical procedures should be made only when circumstances are extreme enough to warrant the use of less than optimal procedures...
- Questioning IACUC composition: is SOCRATES' reasoning correct? Every IACUC can improveLida Anestidou
Center for Clinical and Research Ethics, Vanderbilt University Medical Center, Nashville, TN, USA
Lab Anim (NY) 34:19-20. 2005
- Knowledge about animal suffering is too rarely usedAndrew N Rowan
Nature 417:587. 2002
- Retiring to a chimp paradiseBridget M Kuehn
J Am Vet Med Assoc 222:565-6. 2003
- Minimizing harm in agricultural animal experiments in New ZealandM C Morris
Environmental Studies, School of Earth Sciences, Victoria University of Wellington, P O Box 600, Wellington, New Zealand
J Agric Environ Ethics 16:421-37. 2003..Many of these experiments had questionable short-term applications, had an application restricted to agricultural production or economic growth, or could have been modified to prevent or reduce suffering...
- The refining influence of ethics committees on animal experimentation in SwedenJoakim Hagelin
Department of Physiology, Division of Comparative Medicine, Uppsala University, Box 572, SE 751 23 Uppsala, Sweden
Lab Anim 37:10-8. 2003..In order to have maximal influence on the refinement of scientific protocols it is important that the scientists in the committees are continuously updated on developments in laboratory animal science...
- Dealing with IACUC dysfunctionJames G Christenson
Lab Anim (NY) 33:13. 2004
- Should IACUCs review scientific merit of animal research projects?Michael D Mann
IACUC, Nebraska Medical Center, Omaha, 68198 7830, USA
Lab Anim (NY) 33:26-31. 2004..The authors examine this issue, discuss the pros and cons, suggest how IACUCs can go about reviewing protocols for scientific merit, and question what effect recent changes in regulations will have on this issue...
- Clinical blood draws: when do they require IACUC approval?Stacy Pritt
Animal Resources Facility, Joslin Diabetes Center, Boston, MA, USA
Lab Anim (NY) 33:17-21. 2004
- Reporting noncompliance in the animal facilityVicki Koch
Lab Anim (NY) 32:27. 2003
- Opportunistic research and sampling combined with fisheries and wildlife management actions or crisis responseDavid A Jessup
California Department of Fish and Game, Santa Cruz, CA, USA
ILAR J 44:277-85. 2003..Several unique limitations of sample collection situation are described. It is recommended that IACUCs have mechanisms in place to facilitate good research in all of these circumstances...
- Recognizing and assessing pain, suffering and distress in laboratory animals: a survey of current practice in the UK with recommendationsPenny Hawkins
Research Animals Department, RSPCA, Wilberforce Way, Southwater, West Sussex, RH13 9RS, UK
Lab Anim 36:378-95. 2002..org.uk/pain/(Hawkins 2002). The present paper and the full report, including its recommendations, are intended to provide a source of information, discussion topics and ideas for all establishments that need to monitor animal well-being...
- Programs for invasive research in North American zoos and aquariumsKaren L Goodrowe
Point Defiance Zoo and Aquarium, Tacoma, WA, USA
ILAR J 44:317-23. 2003..A more standardized approach among zoological institutions for examining and approving research projects that are supported by zoo-based conservation programs would greatly facilitate the wildlife research efforts of North American zoos...
- Best practices for animal care committees and animal use oversightW Ron DeHaven
Animal Care Division, US Department of Agriculture s Animal Plant Health Inspection Service, USA
ILAR J 43:S59-62. 2002..These animal care committees (ACCs) are part of an institutional animal welfare team that includes the institutional administration, ..
- Determination of the efficacy of terbinafine hydrochloride nail solution in the topical treatment of dermatophytosis in a guinea pig modelMahmoud A Ghannoum
Center for Medical Mycology, Case Western Reserve University, Cleveland, OH 44106 5028, USA
Mycoses 52:35-43. 2009..Evaluation of the 1%, 5% and 10% TNS in clinical trials for the treatment of dermatophytosis and onychomycosis is warranted...
- Public attitudes in New Zealand towards the use of animals for research, testing and teaching purposesV M Williams
Animal Welfare Group, Biosecurity New Zealand, PO Box 2526, Wellington, New Zealand
N Z Vet J 55:61-8. 2007....
- Factors influencing the effectiveness of research ethics committeesC A Schuppli
Animal Welfare Program, University of British Columbia, 2357 Main Hall, Vancouver, British Columbia, V6T 1Z4, Canada
J Med Ethics 33:294-301. 2007..These results, together with results from the literature on research ethics committees, suggested potential ways to improve the effectiveness of research ethics committees...
- Comparative studies on the topical administration of mucopolysaccharide and heparin ointments in nonhuman primatesDebra A Hoppensteadt
Department of Pathology, Loyola University Chicago, Chicago, Illinois, USA
Clin Appl Thromb Hemost 16:13-20. 2010..In conclusion, MPS showed a stronger release of TFPI than heparin that was not associated with a strong anticoagulant effect. Moreover, MPS downregulated TAFI, resulting in an enhanced fibrinolytic effect...
- Real-time quantitation of renal ischemia using targeted microbubbles: in-vivo measurement of P-selectin expressionSero Andonian
Smith Institute for Urology, North Shore Long Island Jewish Health System, New Hyde Park, New York, USA
J Endourol 23:373-8. 2009..The goal of this project was to use targeted microbubbles outfitted with anti-P-selectin antibodies to quantitate for the first time the microvascular reperfusion injury and regional blood flow in the kidney during IRI...
- Impact of supra-physiologic retinoids on ovalbumin-sensitized f344 lung tissue and reversal of related pathology by citral - biomed 2011Ibrahim O Farah
University of Mississippi Medical Center, Jackson, Mississippi
Biomed Sci Instrum 47:195-200. 2011..These findings warrants further investigation as to the actual role of these interactions in relation to chronic lung disease and the possibility of reversing retinoid-mediated pathologies in the Fisher rat model...
- Radiofrequency ablation combined with liposomal quercetin to increase tumour destruction by modulation of heat shock protein production in a small animal modelWei Yang
Minimally Invasive Tumor Therapies Laboratory, Department of Radiology, Beth Israel Deaconess Medical Center Harvard Medical School, 1 Deaconess Road, Boston, MA 02215, USA
Int J Hyperthermia 27:527-38. 2011..To investigate the effect of heat shock protein (HSP) modulation on tumour coagulation by combining radiofrequency (RF) ablation with adjuvant liposomal quercetin and/or doxorubicin in a rat tumour model...
- Different views on ethics: how animal ethics is situated in a committee cultureM Ideland
Malmo University, Sweden
J Med Ethics 35:258-61. 2009..But committee traditions and priorities of interpretation as well are important to the decisions. The author discusses how "ethics" becomes situated and what implications this may have for committees' decisions...
- Pilot studies of pressure-immobilization bandages for rattlesnake envenomationsWilliam Joel Meggs
Department of Emergency Medicine, Brody School of Medicine, East Carolina University, Greenville, NC, USA
Clin Toxicol (Phila) 48:61-3. 2010..Pilot studies were performed to determine the time of onset of toxicity and efficacy of pressure-immobilizations bandages in a porcine model of rattlesnake envenomation...
- Probiotic acidified formula in an animal model reduces pulmonary and gastric bacterial loadCristiano Boneti
Division of Pediatric Surgery, Department of Surgery, Arkansas Children Hospital, Little Rock, AR 72202, USA
J Pediatr Surg 44:530-3. 2009....
- NOTES: issues and technical details with introduction of NOTES into a small general surgery residency programMichael S Kavic
St Elizabeth Health Center, NEOUCOM for HMHP, Department of Surgery, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44501 1790, USA
JSLS 12:37-45. 2008..The Institutional Animal Care and Use Committee (IACUC) of Northeastern Ohio Universities College of Medicine and Pharmacy (NEOUCOM/COP) approved this study...
- Survey of environmental enhancement programs for laboratory primatesKate C Baker
Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, Louisiana 70433, USA
Am J Primatol 69:377-94. 2007..The data from this survey may be useful for anticipating future program evaluations, establishing more effective internal evaluations, and assessing program progress and resource allocation...
- Expanding the three Rs to meet new challenges in humane animal experimentationCatherine A Schuppli
Animal Welfare Program, Faculty of Agricultural Sciences and W Maurice Young Centre for Applied Ethics, University of British Columbia, 227 6356 Agriculture Road, Vancouver, BC V6T 1Z2, Canada
Altern Lab Anim 32:525-32. 2004..The Three Rs remain very useful, but they require thoughtful interpretation and expansion in order for Animal Ethics Committees to address the full range of issues in animal-based research...
- 108 a critical-size craniofacial bone defect model in the yorkshire pigA J Maki
University of Illinois, Urbana
Reprod Fertil Dev 23:159. 2011..This porcine model will allow for the rapid development and testing of new approaches for the repair of damaged bone, which is especially prevalent in the craniofacial area...
- Effects of interleukin-6 ablation on fracture healing in miceAaron Wallace
Penn State Hershey Medical Center, Hershey, Pennsylvania, USA
J Orthop Res 29:1437-42. 2011..110). The absence of IL-6 during early fracture healing significantly reduced osteoclastogenesis and impaired callus strength. By 6 weeks, most histological and biomechanical parameters were similar to fractures in wild-type bone...
- Neuromuscular effects of stun device dischargesDaniel J Valentino
Cook Country Trauma Unit, Chicago, Illinois, USA
J Surg Res 143:78-87. 2007..To examine this type of electrical injury, we hypothesized that EMI discharges will induce acute or delayed cardiac arrhythmia and neuromuscular injury in an animal model...
- The interpretation and application of the three Rs by animal ethics committee membersCatherine A Schuppli
The W Maurice Young Centre for Applied Ethics, The University of British Columbia, 227 6356 Agricultural Road, Vancouver, BC V6T 1Z2, Canada
Altern Lab Anim 33:487-500. 2005....
- Data and animal management software for large-scale phenotype screeningKeith A Ching
Genomics Institute, Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA
Mamm Genome 17:288-97. 2006..MouseTRACS is available under an open source license at http://www.mousetracs.sourceforge.net...
- Introducing ethical evaluation of the use of animals in experiments in the Near EastSerdar Izmirli
Department of History of Veterinary Medicine and Deontology, Selcuk University, Konya, Turkey
Altern Lab Anim 38:331-6. 2010..The recent establishment of animal ethical review in the Near East could benefit from experiences in Western countries, in their evolution toward high standards of experimental animal ethics...
- Immunologic parameters during NOTES compared with laparoscopy in a randomized blinded porcine trialJuliane Bingener
Department of Surgery, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA
Surg Endosc 23:178-81. 2009..We hypothesized that there would be no difference between cytokine levels during NOTES or laparoscopic peritoneoscopy...
- Transvaginal endoscopic partial gastrectomy in porcine models: the role of an extra endoscope for gastric controlKiyokazu Nakajima
Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
Surg Endosc 22:2733-6. 2008..The aim of this study was to investigate the feasibility of transvaginal NOTES gastrectomy with the use of an extra endoscope as a retracting device of the stomach...
- Hindlimb unloading rodent model: technical aspectsEmily R Morey-Holton
Life Sciences Division, NASA Ames Research Center, Moffett Field, California 94035 1000, USA
J Appl Physiol (1985) 92:1367-77. 2002..Over 800 references, related to the hindlimb unloading model, can be accessed via the electronic version of this article...
- Laboratory guidelines for animal careMarcelo Couto
UCLA School of Medicine DLAM, Los Angeles, CA, USA
Methods Mol Biol 770:579-99. 2011..Guidance is provided regarding the appropriate handling of regulatory noncompliances...
- The feasibility of inducing mild therapeutic hypothermia after cardiac resuscitation using iced saline infusion via an intraosseous needleTimothy J Mader
Department of Emergency Medicine, Baystate Medical Center Tufts University School of Medicine, Springfield, MA, USA
Resuscitation 81:82-6. 2010....
- Micro-CT analysis with multiple thresholds allows detection of bone formation and resorption during ultrasound-treated fracture healingTheresa A Freeman
Department of Orthopedic Surgery, Thomas Jefferson University, Curtis Building, Suite 501, 1015 Walnut Street, Philadelphia, Pennsylvania 19107 5099, USA
J Orthop Res 27:673-9. 2009..Results of the study indicate that at sites of bone turnover, this multithresholding analytical technique can be used to provide quantitative information on bone formation, as well as resorption...
- Blast exposure in rats with body shielding is characterized primarily by diffuse axonal injuryRobert H Garman
Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
J Neurotrauma 28:947-59. 2011..Strikingly, silver staining revealed otherwise undetected abnormalities, and therefore represents a recommended outcome measure in future studies of blast TBI...
- TASER X26 discharges in swine produce potentially fatal ventricular arrhythmiasRobert J Walter
Cook County Trauma Unit, John Stroger Hospital of Cook County, Rush University Medical Center, Chicago, IL, USA
Acad Emerg Med 15:66-73. 2008..The authors hypothesized that TASER discharges degrade cardiac performance through a mechanism not involving concurrent acidosis...
- Taser X26 discharges in swine: ventricular rhythm capture is dependent on discharge vectorDaniel J Valentino
Cook County Trauma Unit, John Stroger Hospital of Cook County, Chicago, Illinois 60612, USA
J Trauma 65:1478-85; discussion 1485-7. 2008..We hypothesized that most transcardiac discharge vectors would capture ventricular rhythm, but that other vectors, not traversing the heart, would fail to capture the ventricular rhythm...
- Transvaginal natural orifice translumenal endoscopic surgery cholecystectomy: early evolution of the techniqueAndrew A Gumbs
Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
Ann Surg 249:908-12. 2009..After safely performing laparoscopically-assisted transvaginal cholecystectomy in an IACUC-approved porcine model, we embarked on an IRB-approved protocol to ultimately perform a pure NOTES cholecystectomy...
- [Global harmonization in the care and use of laboratory animals for the space life science research]K Katahira
Experimental Animal Center, Fukushima Medical University, Fukushima, Japan
Biol Sci Space 15:30-4. 2001..Even if researchers have protocols of the space science in Japan, the animal experiment should be carried out under the global harmonized conditions in accordance with NIH policies and NASA guides...
- Effect of cage enrichment on the daily use of running wheels by Syrian hamstersStéphan G Reebs
Departement de Biologie, Universite de Moncton, Moncton, NB, Canada
Chronobiol Int 20:9-20. 2003Institutional animal care committees may one day require for the welfare of captive hamsters more floor space and the introduction of tunnels and toys...
- Determination of sample sizes for demonstrating efficacy of radiation countermeasuresRalph L Kodell
Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Biometrics 66:239-48. 2010....
- Management of rodent viral disease outbreaks: one institutions (r)evolutionAbigail L Smith
Department of Pathobiology, University Laboratory Animal Resources, University of Pennsylvania, 3800 Spruce Street, Suite 177E OVQ, Philadelphia, PA 19104, USA
ILAR J 51:127-37. 2010..This evolution required not only support from the highest levels of leadership in the university and its school of medicine but also a huge outlay of financial resources...
- Refinement of the use of food and fluid control as motivational tools for macaques used in behavioural neuroscience research: report of a Working Group of the NC3RsMark J Prescott
National Centre for the Replacement, Refinement and Reduction of Animals in Research NC3Rs, 20 Park Crescent, London, UK
J Neurosci Methods 193:167-88. 2010..The report provides a framework for refinement that can be tailored to meet local requirements. It also identifies data gaps and areas for future research and sets out the Working Group's recommendations on contemporary best practice...
- Establishing procedures for institutional oversight of stem cell researchPatricia Zettler
Stanford Law School, Stanford, CA, USA
Acad Med 82:6-10. 2007..The SCRO neither replaces nor duplicates review by the IRB and institutional animal care and use committees. Other AHCs can draw on the UCSF experience when developing their own policies and procedures for stem cell research oversight...
- A porcine model for progressive thoracic scoliosisFrank Schwab
New York University Hospital for Joint Diseases, New York, NY, USA
Spine (Phila Pa 1976) 34:E397-404. 2009..An IACUC-approved study to create a scoliotic deformity representative of adolescent idiopathic scoliosis...
- The survival and function of baboon red blood cells, platelets, and plasma proteins: a review of the experience from 1972 to 2002 at the Naval Blood Research Laboratory, Boston, MassachusettsC Robert Valeri
Naval Blood Research Laboratory, Boston, Massachusetts 02360, USA
Transfusion 46:1S-42S. 2006....
- Invertebrate models for biomedical research, testing, and educationSusan E Wilson-Sanders
University Animal Care, University of Arizona, Tucson, AZ 85724 5092, USA
ILAR J 52:126-52. 2011..The models reviewed can serve as references for scientists, researchers, veterinarians, institutional animal care and use committees (IACUCs), and others interested in alternatives to vertebrate animals...
- Telemetric recording of intrapleural pressureMathew D Ednick
Department of Pediatrics, Maimonides Infants and Children s Hospital, Brooklyn, New York 11219, USA
J Surg Res 138:10-4. 2007..We describe a telemetric method of non-invasive monitoring of the IPP in conscious animals intermittently or continuously for a prolonged period of time...
- Degenerative changes following spinal fixation in a small animal modelGregory D Cramer
Department of Research, National University of Health Sciences, 200 E Roosevelt Road, Lombard, IL 60148, USA
J Manipulative Physiol Ther 27:141-54. 2004..The objective of this study was to evaluate changes of the lumbar vertebral column following fixation...
- IACUC Challenges in Invertebrate ResearchChris Harvey-Clark
Animal Care Centre, University of British Columbia, Vancouver, Canada
ILAR J 52:213-20. 2011....
- Metastatic human colonic carcinoma: molecular imaging with pretargeted SPECT and PET in a mouse modelRobert M Sharkey
Center for Molecular Medicine and Immunology, Garden State Cancer Center, 520 Belleville Ave, Belleville, NJ 07109, USA
Radiology 246:497-507. 2008..To prospectively determine if a bispecific monoclonal antibody (MoAb) pretargeting method with a radiolabeled hapten peptide can depict small (<0.3 mm in diameter) microdisseminated human colon cancer colonies in the lungs of nude mice...
- Computed tomographic validation of the porcine model for thoracic scoliosisAshish Patel
Department of Orthopaedics, NYU Hospital for Joint Diseases, New York, NY 10010, USA
Spine (Phila Pa 1976) 35:18-25. 2010..Computed Tomographic Analysis of the Porcine Scoliosis Model...
- Apoptotic cells, autoantibodies, and the role of HMGB1 in the subcellular localization of an autoantigenAmy N Sanford
Division of Allergy and Immunology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Autoimmun 25:264-71. 2005..This is the first description of an inflammatory stimulus altering the immunologic availability of a potential autoantigen...
- Inhibition of C5 or absence of C6 protects from sepsis mortalityJon A Buras
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Immunobiology 209:629-35. 2004..Inhibition of the complement MAC does not increase bacterial load or mortality, therefore, the use of anti-C5 therapy may be beneficial rather than detrimental in sepsis...
- Novel endoscopic application of a new flexible-fiber CO2 laser for esophageal mucosal ablation in a porcine modelS Anandasabapathy
Division of Gastroenterology, M D Anderson Cancer Center, Houston, Texas, USA
Endoscopy 41:138-42. 2009..The aim of the current study was to evaluate the performance, efficacy, and safety of a novel, photonic band-gap CO (2) laser configured for esophageal mucosal ablation...
- A renewed look at laboratory rodent housing and managementJanet C Gonder
Garber Consulting LLC, Pinehurst, NC, USA
ILAR J 48:29-36. 2007..This new information is provided to aid IACUCs and facility managers in making decisions regarding the housing and care of laboratory rodents...
- Role of Endothelin System and NAD(P)H Oxidase in Retinal Arteriolar DysfunctionTRAVIS HEIN; Fiscal Year: 2009..Project Description Page 6 ..
- Superantigen-Induced Vascular Injury and DICJACK J HAWIGER; Fiscal Year: 2010..Project Description Page 6 ..
- Extracellular superoxide induces Egr-1 in the hypoxic pulmonary arteryEVA GRAYCK; Fiscal Year: 2009..a solid foundation for future human clinical trials in a range of scenarios associated with hypoxic lung diseases to improve health outcome for patients with these difficult and serious problems Project Description Page 6 ..
- Neurotrophin Regulation of the Airway Parasympathetic Nervous SystemAllen Myers; Fiscal Year: 2009..Project Description Page 6 ..
- Prognostic Impact and Arrhythmic Potential of Peri-infarct Zone by Cardiac MRIRaymond Kwong; Fiscal Year: 2009..Project Description Page 6 Raymond Y. Kwong, MD 2/5/07 2:09 AM 30 Page of 38 ..
- Molecular Basis for Lens TransparencyHassane McHaourab; Fiscal Year: 2009..Project Description Page 6 ..
- Glucocorticoid control of gene expression during skeletal muscle atrophyJ DAVID contact FURLOW; Fiscal Year: 2010..Newly developed genetic resources, pharmacological tools, and molecular techniques are available to accomplish these aims in the investigator's laboratories and through ..
- POLYADENYLATION AND TRANSLATIONAL CONTROLJoel Richter; Fiscal Year: 2009..Finally, an upstream event that is necessary for CPEB-mediated polyadenylation is the translational activation of RINGO/Spy mRNA, which encodes an atypical cyclin B1-like protein. Pumilio is the ..
- Duox2 Modulation of Viral Infection in Airway EpitheliumRichart Harper; Fiscal Year: 2009..These foundational studies will allow us to investigate specific mechanisms responsible for RV-induced asthma exacerbations in the future. Project Description Page 6 ..
- Epidemiologic Study on Changing HIV Risks Among FSW-IDUs on the Mexico-US BorderSteffanie Strathdee; Fiscal Year: 2009..Interventions that reduce HIV risks among FSW-IDUs may curtail the burgeoning HIV epidemic in the U.S-Mexico border region, and have applicability to other resource-poor countries. Project Description Page 7 ..
- Neuronal Plasticity and Recovery of Function After StrokeGWENDOLYN KARTJE MD; Fiscal Year: 2009..Project Description Page 6 ..
- CT Diagnosis of Tracheomalacia in Patients with COPDPhillip Boiselle; Fiscal Year: 2009..in the absence of intervention among subjects who are asymptomatic or mildly symptomatic; and Aim 4: Identify factors that are predictive of a positive response to intervention by assessing longitudinal changes in ..
- CYP4F3 in renal inflammationPeter Christmas; Fiscal Year: 2010..Project Description Page 6 ..
- NFATc3 in chronic hypoxic pulmonary hypertensionLaura Gonzalez Bosc; Fiscal Year: 2009..A better understanding of this mechanisms in PAH will lead to the development of novel therapeutic approaches to prevent and cure this debilitating disease. Project Description Page 6 ..
- Mechanisms of Endothelial Cell HyperpolarizationSEAN MARRELLI; Fiscal Year: 2009..Project Description Page 6 ..
- Effect of Insulin and Propranolol on Post Burn Hypermetabolism and InflammationDavid N Herndon; Fiscal Year: 2010..Project Description Page 7 ..
- Improvement of communication process and outcomes after newborn genetic screeningMichael Farrell; Fiscal Year: 2009..Progress in this area may address many ethical concerns and generalize to other areas of communication in health care. Project Description Page 7 ..
- Modifiers of Tumor Susceptibility in Murine NeuroblastomaWilliam Weiss; Fiscal Year: 2009..Aim 3 validates and characterizes candidate genes in-vitro and in-vivo, prioritizing based on the involvement of specific candidate genes in human neuroblastoma. Project Description Page 6 ..
- Sensory-Motor Control of the Binocular Near ResponseCLIFTON SCHOR; Fiscal Year: 2009..Project Description Page 6 ..
- Flavoenzymes in Pyrimidine MetabolismBruce A Palfey; Fiscal Year: 2010..We will determine the substrate specificities of selected model DUSs and probe the interactions of the protein and tRNA by chemical and biophysical means. Project Description Page 6 ..
- A Curriculum for Clinical Research Training in VermontBenjamin Littenberg; Fiscal Year: 2007..I am aware that any false, fictitious, or fraudulent statements or claims may subject me to criminal,civil, or administrative penalties. PHS 398 (Rev. 05/01 Face Page Form Page 1 ..
- Ventricular Fibrillation in a Globally Ischemic Heart: From Cell to ECGAlexey Zaitsev; Fiscal Year: 2009..3. To establish the link between the temporal regularity of the action potential, the dynamics of propagating wavelets, and the ECG during natural VF evolution in-situ. Project Description Page 6 ..
- Factors Controlling Metabolic Flux in the Liver by NMR Isotopomer AnalysisShawn C Burgess; Fiscal Year: 2010..Nuclear magnetic resonance (NMR) isotopomer analysis will be used to measure metabolic fluxes and these techniques will be corroborated by simultaneous hepatic mass balance determinations. Project Description Page 6 ..
- Immunization Strategies for Autologous HIV ImmunotherapyLouis D Falo; Fiscal Year: 2010..Importantly, the studies we propose include translational preclinical models designed as a direct prelude to human clinical trials. Project Description Page 6 ..
- Behavioral and Neural Correlates of Melodic Intonation TherapyGottfried Schlaug; Fiscal Year: 2009..Secondary outcome measures include correctly named items on standard picture naming tests, timed automatic speech, and linguistically-based measures of phrase and sentence analysis. Project Description Page 6 ..
- VASCULAR ESTROGEN RECEPTOR SIGNALING PATHWAYSRichard Karas; Fiscal Year: 2009..Project Description Page 6 ..
- Targeting myofibroblast activation in chronic fibrotic diseaseArthur Strauch; Fiscal Year: 2009..Project Description Page 6 ..
- Human Umami Taste: Genetics of Psychophysical TraitsPaul Breslin; Fiscal Year: 2009..II. Characterize any umami perceptual phenotypes related to glutamate receptor SNPs. III. Define variant glutamate receptor stimulus-response functions in expression assays. Project Description Page 6 ..
- T-tubule remodeling and Ca2+-dependent arrhythmogenesis in cardiomyopathies.Long Sheng Song; Fiscal Year: 2009..Project Description Page 6 ..
- Mechanisms of regulation of LRH-1, Nanog and SF-1 by DAX-1Robert Fletterick; Fiscal Year: 2009..Learning the mechanisms of action of these receptors, and what goes wrong in the diseases, will help suggest pathways for design of new drug treatments for these conditions. Project Description Page 6 ..
- Vascular Surgery - Estrogen and the Injury ResponseMichael Mendelsohn; Fiscal Year: 2009..cell ER regulates eNOS expression and activity; vascular smooth muscle cell (VSMC) ER mediates estrogen inhibition of VSMC proliferation during vascular injury and atherosclerosis; and VSMC ER controls genes encoding ..
- Role of DPPI & Serine Proteases in Inflammatory DiseasesCHRISTINE T PHAM; Fiscal Year: 2010..We also hypothesize that decreased expression of complement regulators in the kidney may be a determinant that influences disease severity in target organ. Project Description Page 6 ..
- Caveolin-1 and NO Regulate PMN-mediated Increases in Vascular PermeabilityRichard Minshall; Fiscal Year: 2009..Project Description Page 6 ..
- Plasmalemma permeability: A therapeutic target for traumatic brain injury?Michael J Whalen; Fiscal Year: 2010..The proposed studies are intended to show that loss of plasmalemma integrity is a therapeutic target to rescue injured cells in patients with TBI. Project Description Page 6 ..
- T Cell Functionality and Control of Acute HIV InfectionMICHAEL BETTS; Fiscal Year: 2009..In this proposal, we will determine how the immune system fights HIV during early infection and apply this knowledge to the development and testing of HIV vaccines. Project Description Page 7 ..
- Locus-Specific Imprinting on the Mammalian X ChromosomeMICHAEL O NEILL; Fiscal Year: 2009..Finally, we will produce mutant mice by gene targeting that lack certain elements that preliminary results suggest are ..
- Mechanisms of UV-induced skin carcinogenesisLaura Hansen; Fiscal Year: 2009..Project Description Page 6 ..
- Functional biology of IL-25 during helminth infectionDavid Artis; Fiscal Year: 2010..Project Description Page 6 ..
- Mechanistic Studies on Lung Cancer Prevention by Tea PolyphenolsChung Yang; Fiscal Year: 2009..Project Description Page 6 ..
- Regulation of Airway Morphogenesis and Differentiation by Wnt SignalingEdward Morrisey; Fiscal Year: 2009..Project Description Page 6 ..
- Signaling in Tissue Injury and RepairRobert Diegelmann; Fiscal Year: 2007..The Program Director has made concerted efforts and will continue to strive to attract underrepresented minorities to apply to this unique training program. ..
- Nox4 and Cardiac FibrosisDan Sorescu; Fiscal Year: 2009..We will test whether Nox4 is essential in vivo in Ang II-induced cardiac fibrosis by using Nox4 knockout or Nox4 overexpressing mice. Project Description Page 6 ..
- Human Subjects Research Enhancement ProgramStephen Slogoff; Fiscal Year: 2002..Two computers, a laptop and a video camera are the only requirements for this enhancement. ..
- Membrane Fusion, Organization, and Dynamics Using Supported BilayersSTEVEN BOXER; Fiscal Year: 2009..Each aim depends upon the development of new supported lipid bilayer architectures and analytical methods that can have a broad impact on studies of biological membranes. Project Description Page 6 ..
- Tetrahydrobiopterin and painClifford J Woolf; Fiscal Year: 2009..The proposal is designed to explore the molecular mechanisms responsible for pain and identify novel targets for the development of new analgesics. Project Description Page 7 ..
- A mouse model of myelodysplastic syndrome progression and leukemic stem cellsYupo Ma; Fiscal Year: 2009..Project Description Page 6 ..
- Stress Granules Cause Translation Arrest In Ischemic Vulunerable NeuronsDONALD DEGRACIA; Fiscal Year: 2009..Project Description Page 6 ..
- Role of the Aryl Hydrocarbon Receptor in Lung InflammationPatricia Sime; Fiscal Year: 2009..Despite the fact that smoking causes lung diseases, remarkably little is known of the mechanisms whereby smoke generates inflammation and how the inflammatory responses are regulated. The fibroblast is a ..
- Synapse formation in the C. elegans nervous systemChristopher Rongo; Fiscal Year: 2009..The molecular and cell biological function of these new genes will provide clues to the mechanisms by which glutamate receptors are regulated. Project Description Page 6 ..
- Endothelial cell junctions in mechanotransductionEleni Tzima; Fiscal Year: 2009..Project Description Page 6 ..
- A novel G protein signaling pathway controlling Drosophila cardiac morphogenesisZhe Han; Fiscal Year: 2009..These studies will fill a significant gap in the research field of heart development, and promote our understanding of the molecular mechanism of congenital heart disease. Project Description Page 6 ..
- Determinates of anti-HIV nucleic acid aptamer potency and resistanceDonald Burke; Fiscal Year: 2009..Aim 4 evaluates the de novo evolution of aptamer resistance with emphasis on establishing genetic threshold, resistance loci, and the molecular basis of resistance. Project Description Page 6 ..
- Prolonged Analgesia in RodentsJames Johnson; Fiscal Year: 2007..If this formulation is successful, it could be used for other laboratory animals with appropriate dose adjustment. ..