formal social control


Summary: Control which is exerted by the more stable organizations of society, such as established institutions and the law. They are ordinarily embodied in definite codes, usually written.

Top Publications

  1. ncbi Tobacco industry direct marketing after the Master Settlement Agreement
    M Jane Lewis
    University of Medicine and Dentistry of New Jersey, School of Public Health, New Brunswick, New Jersey, USA
    Health Promot Pract 5:75S-83S. 2004
  2. ncbi Youth access interventions do not affect youth smoking
    Caroline M Fichtenberg
    Center for Tobacco Control Research and Education, Institute for Health Policy Studies, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94143 0130, USA
    Pediatrics 109:1088-92. 2002
  3. ncbi Compliance with a minimum-age law of 18 for the purchase of tobacco--the case of Sweden
    Mona Sundh
    Public Health, Karlstad University, SE 651 88 Karlstad, Sweden
    Health Educ Res 21:378-85. 2006
  4. pmc Tobacco, commercial speech, and libertarian values: the end of the line for restrictions on advertising?
    Ronald Bayer
    Program in the History and Ethics of Public Health and Medicine, Division of Sociomedical Sciences, Mailman School of Public Health, Columbia University, 600 W 168th Street, New York, NY 10032, USA
    Am J Public Health 92:356-9. 2002
  5. ncbi The Master Settlement Agreement and African Americans: opinions about the allocation of resources
    Gary King
    Pennsylvania State University, University Park, Pennsylvania, USA
    Health Promot Pract 5:135S-142S. 2004
  6. pmc Corporate speech and the Constitution: the deregulation of tobacco advertising
    Lawrence O Gostin
    Center for Law and the Public s Health, Georgetown University Law Center, 600 New Jersey Avenue NW, Washington, DC 20001, USA
    Am J Public Health 92:352-5. 2002
  7. ncbi Counteracting cigarette advertising
    Alan B Morrison
    Stanford Law School, 559 Nathan Way, Room 215, Stanford, CA 94305, USA
    JAMA 287:3001-3. 2002
  8. pmc Expressive freedom and tobacco advertising: a Canadian perspective
    Christopher P Manfredi
    Department of Political Science, McGill University, 855 Sherbrooke Street, Montreal, Quebec, Canada H31 2T7
    Am J Public Health 92:360-2. 2002
  9. ncbi Tobacco advertising in the United States: a proposal for a constitutionally acceptable form of regulation
    Ronald Bayer
    Mailman School of Public Health, Columbia University, 722 W 168th St, Ninth Floor, New York, NY 10032, USA
    JAMA 287:2990-5. 2002
  10. ncbi Tobacco advertising and freedom of speech
    Richard J Bonnie
    JAMA 288:1587; author reply 1587-8. 2002

Detail Information

Publications921 found, 100 shown here

  1. ncbi Tobacco industry direct marketing after the Master Settlement Agreement
    M Jane Lewis
    University of Medicine and Dentistry of New Jersey, School of Public Health, New Brunswick, New Jersey, USA
    Health Promot Pract 5:75S-83S. 2004
    ..This article suggests that a first step in countering these practices is to increase awareness and understanding of them, followed by development of strategies to address them and to limit or eliminate their use in tobacco marketing...
  2. ncbi Youth access interventions do not affect youth smoking
    Caroline M Fichtenberg
    Center for Tobacco Control Research and Education, Institute for Health Policy Studies, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94143 0130, USA
    Pediatrics 109:1088-92. 2002
    ..To determine the effectiveness of laws restricting youth access to cigarettes on prevalence of smoking among teens...
  3. ncbi Compliance with a minimum-age law of 18 for the purchase of tobacco--the case of Sweden
    Mona Sundh
    Public Health, Karlstad University, SE 651 88 Karlstad, Sweden
    Health Educ Res 21:378-85. 2006
    ..The study also indicates great potential for local efforts to induce more retailers to comply with the law...
  4. pmc Tobacco, commercial speech, and libertarian values: the end of the line for restrictions on advertising?
    Ronald Bayer
    Program in the History and Ethics of Public Health and Medicine, Division of Sociomedical Sciences, Mailman School of Public Health, Columbia University, 600 W 168th Street, New York, NY 10032, USA
    Am J Public Health 92:356-9. 2002
    ..In so doing, the court underscored the enduring tension between the libertarian and social welfare dimensions of contemporary democracy and placed into relief the divisions within the American liberal tradition...
  5. ncbi The Master Settlement Agreement and African Americans: opinions about the allocation of resources
    Gary King
    Pennsylvania State University, University Park, Pennsylvania, USA
    Health Promot Pract 5:135S-142S. 2004
    ..S. society...
  6. pmc Corporate speech and the Constitution: the deregulation of tobacco advertising
    Lawrence O Gostin
    Center for Law and the Public s Health, Georgetown University Law Center, 600 New Jersey Avenue NW, Washington, DC 20001, USA
    Am J Public Health 92:352-5. 2002
  7. ncbi Counteracting cigarette advertising
    Alan B Morrison
    Stanford Law School, 559 Nathan Way, Room 215, Stanford, CA 94305, USA
    JAMA 287:3001-3. 2002
  8. pmc Expressive freedom and tobacco advertising: a Canadian perspective
    Christopher P Manfredi
    Department of Political Science, McGill University, 855 Sherbrooke Street, Montreal, Quebec, Canada H31 2T7
    Am J Public Health 92:360-2. 2002
    ..While the Canadian government could have used the decision to justify withdrawing from further confrontations with powerful commercial interests, it chose instead to enact new tobacco control legislation in 1997...
  9. ncbi Tobacco advertising in the United States: a proposal for a constitutionally acceptable form of regulation
    Ronald Bayer
    Mailman School of Public Health, Columbia University, 722 W 168th St, Ninth Floor, New York, NY 10032, USA
    JAMA 287:2990-5. 2002
    ..However, this would be a battle worth engaging, because it might have an impact on tobacco-related morbidity and mortality in the United States...
  10. ncbi Tobacco advertising and freedom of speech
    Richard J Bonnie
    JAMA 288:1587; author reply 1587-8. 2002
  11. ncbi Tobacco advertising and freedom of speech
    Terence A Gerace
    JAMA 288:1586; author reply 1587-8. 2002
  12. ncbi Will the master settlement agreement achieve a lasting legacy?
    Cheryl G Healton
    American Legacy Foundation, Washington, DC, USA
    Health Promot Pract 5:12S-17S. 2004
    ..The inextricable link between Legacy, state tobacco control, and the politics of tobacco are discussed...
  13. ncbi Commentary: the Master Settlement Agreement in historic context
    John Seffrin
    American Cancer Society, National Home Office, Atlanta, Georgia, USA
    Health Promot Pract 5:18S-20S. 2004
  14. ncbi Cochrane column: commentary: interventions for preventing tobacco sales to minors
    Derek Yach
    Global Public Health, Yale School of Public Health, USA
    Int J Epidemiol 35:32. 2006
  15. pmc Cigarette acquisition and proof of age among US high school students who smoke
    S Everett Jones
    Division of Adolescent and School Health, National Center for Chronic Disease Prevention and Health Promotion NCCDPHP, Centers for Disease Control and Prevention CDC, Atlanta, Georgia 30341, USA
    Tob Control 11:20-5. 2002
    ..To determine how US high school students who are under 18 years of age and who smoke obtain their cigarettes and whether they are asked for proof of age...
  16. ncbi The effect of enforcement of the Master Settlement Agreement on youth exposure to print advertising
    Alan Lieberman
    California Attorney General s Tobacco Litigation and Enforcement Section, Sacramento, California, USA
    Health Promot Pract 5:66S-74S. 2004
  17. ncbi After the Master Settlement Agreement: trends in the American tobacco retail environment from 1999 to 2002
    Erin Ruel
    Center for Demography of Health and Aging, University of Wisconsin Madison, USA
    Health Promot Pract 5:99S-110S. 2004
    ..Tobacco promotions in stores increased between 2001 and 2002. Stores in the south and rural areas tended to have the lowest prices and highest prevalence of promotions and advertising, suggesting a need for tobacco control intervention...
  18. ncbi [Social responsibility argument for the tobacco industry in Brazil]
    Tania Cavalcante
    División del Control del Tabaquismo y otros factores de riesgo, Instituto Nacional del Cancer, Secretaria de Salud, Brasil
    Salud Publica Mex 48:S173-82. 2006
  19. ncbi Emerging technological approaches for controlling the hard core DUI offender in the U.S
    Robert B Voas
    Pacific Institute for Research and Evaluation, Calverton, Maryland, USA
    Traffic Inj Prev 5:309-16. 2004
    ..Although those technologies offer considerable promise, they have not yet been evaluated in programs for impaired driving offenders. Eight issues related to the probability of rapid implementation of the new technologies are discussed...
  20. ncbi Is restricting tobacco sales the answer to adolescent smoking?
    M Staff
    Public Health Unit, Northern Sydney Health, Sydney, Australia
    Prev Med 37:529-33. 2003
    ..There was no reduction in adolescent smoking with active enforcement of tobacco access laws despite an apparent increase in students who reported never to have smoked...
  21. ncbi [Cigarette smuggling: a wide scope phenomenon only there to serve the interests of big tobacco manufacturers]
    Louis Gauvin
    Coalition Québecoise pour le Contróle du Tubac, Montreal, QC
    Promot Educ . 2005
  22. doi Tobacco compliance check in Hong Kong
    Ming yue Kan
    Committee on Youth Smoking Prevention, Wan Chai, Hong Kong
    Nicotine Tob Res 10:337-40. 2008
    ..Periodic tobacco compliance checks should be adopted in Hong Kong to exert pressure on law enforcement bodies and tobacco retailers...
  23. ncbi A qualitative study of post-settlement influences on State tobacco control funding
    Joy Austin-Lane
    Department of Preventive Medicine and Biometrics at the Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Health Promot Pract 5:46S-56S. 2004
    ..A conceptual diagram is presented of all factors clustered into three categories. Further research is planned to quantify these factors and assess their explanatory value..
  24. ncbi An analysis of tobacco industry marketing to lesbian, gay, bisexual, and transgender (LGBT) populations: strategies for mainstream tobacco control and prevention
    Perry Stevens
    Strategic Initiatives for the Tobacco Technical Assistance Consortium, Rollins School of Public Health, Emory University, Atlanta, Geaorgia, USA
    Health Promot Pract 5:129S-134S. 2004
    ..Reducing LGBT smoking rates is a public health challenge that will require exceeding the sense of validation tobacco advertising has created in LGBT communities...
  25. ncbi The 1998 Master Settlement Agreement: a public health opportunity realized--or lost?
    Dearell Niemeyer
    Tobacco Technical Assistance Consortium, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    Health Promot Pract 5:21S-32S. 2004
    ..Moreover, tobacco companies have continued aggressive marketing efforts to reach youth...
  26. ncbi Identifying and responding to technical assistance and training needs in tobacco prevention and control
    Amber Hardy Thornton
    American Legacy Foundation, Washington, DC, USA
    Health Promot Pract 5:159S-166S. 2004
    ..Training and technical assistance can be the solution to sustaining impetus in the movement...
  27. ncbi Supporting and sustaining the tobacco control movement
    Paul Florin
    University of Rhode Island, USA
    Health Promot Pract 5:157S-158S. 2004
  28. ncbi More money more motivation? Master Settlement Agreement and tobacco control funding in communities of color
    Makani Themba-Nixon
    Praxis Project PATH, Washington, DC, USA
    Health Promot Pract 5:113S-128S. 2004
    ..Findings supported our hypothesis that there were few dedicated resources at the state level for tobacco control and prevention in communities of color...
  29. ncbi Advocating for dollars: unanticipated lessons in allocating Master Settlement Agreement funds
    Phillip Wilbur
    American Heart Association, Washington, DC, USA
    Health Promot Pract 5:33S-34S. 2004
  30. pmc Tobacco control in India
    Riti Shimkhada
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA, USA
    Bull World Health Organ 81:48-52. 2003
    ..The Indian Government must also introduce policies to raise taxes, control smuggling, close advertising loopholes, and create adequate provisions for the enforcement of tobacco control laws...
  31. ncbi [War on Drugs or War against Health? The pitfalls for public health of Puerto Rican drug policy]
    Salvador Santiago-Negrón
    Universidad Carlos Albizu, San Juan, Puerto Rico
    P R Health Sci J 22:49-59. 2003
    ..It also presents those principles that should sustain pragmatic drug policy to address problematic drug use from a health and social perspective...
  32. pmc Underreporting of justifiable homicides committed by police officers in the United States, 1976-1998
    Colin Loftin
    Violence Research Group, School of Criminal Justice, University at Albany, State University of New York, 12222, USA
    Am J Public Health 93:1117-21. 2003
    ..This study assessed the consistency of estimates of the number of justifiable homicides committed by US police officers and identified sources of underreporting...
  33. ncbi An example of international drug politics--the development and distribution of substance prevention programs directed at adolescents
    John Lilja
    Department of Biochemistry and Pharmacy, Abo Akademi University, Turku, Finland
    Subst Use Misuse 42:317-42. 2007
    ..A social competence framework might be used as both a goal and as a theoretical base to achieve a better understanding of the processes by which substance use prevention programs reach their effects...
  34. ncbi Youth targeting by tobacco manufacturers since the Master Settlement Agreement
    Paul J Chung
    Department of Pediatrics, University of Chicago, USA
    Health Aff (Millwood) 21:254-63. 2002
    ..Banning all magazine advertising of cigarettes may be necessary to eliminate youth targeting in magazines...
  35. ncbi The shifting terrain of tobacco advertising since the Master Settlement Agreement
    Tess B Cruz
    Institute for Prevention Research, Keck School of Medicine, University of Southern California, Alhambra, California, USA
    Health Promot Pract 5:64S-65S. 2004
  36. ncbi Exploring the rise in American pharmaceutical prices
    Amitoi Marwaha
    Medical College of Wisconsin, USA
    Pharos Alpha Omega Alpha Honor Med Soc 65:11-5. 2002
  37. ncbi The Canadians are killing us
    Robert A Struble
    Pharos Alpha Omega Alpha Honor Med Soc 65:58-9. 2002
  38. ncbi Criminal law, policing policy, and HIV risk in female street sex workers and injection drug users
    Kim M Blankenship
    Department of Epidemiology and Public Health, Center for Interdisciplinary Research on AIDS, Yale University, USA
    J Law Med Ethics 30:548-59. 2002
  39. ncbi American pharmaceutical prices
    Peter Alagona
    Pharos Alpha Omega Alpha Honor Med Soc 65:58. 2002
  40. ncbi The public health approach to motor vehicles, tobacco, and alcohol, with applications to firearms policy
    D Hemenway
    Harvard Injury Control Research Center, Harvard School of Public Health, 677 Huntington Avenue, Boston, Massachusetts 02115, USA
    J Public Health Policy 22:381-402. 2001
    ..The endeavor to reduce gun violence is part of the general and continuing public health struggle to reduce harms caused by consumer products...
  41. ncbi From Asilomar to industrial biotechnology: risks, reductionism and regulation
    Sheldon Krimsky
    Department of Urban and Environmental Policy and Planning, Tufts University, Medford, MA 02155, USA
    Sci Cult (Lond) 14:309-23. 2005
  42. ncbi Reflections on public bioethics: a view from the trenches
    Leon R Kass
    University of Chicago, IL, USA
    Kennedy Inst Ethics J 15:221-50. 2005
  43. ncbi State policies and nurses with substance use disorders
    Mary R Haack
    College of Nursing, Rutgers, State University of New Jersey, Newark, NJ, USA
    J Nurs Scholarsh 34:89-94. 2002
    ..To investigate the effects of two state regulatory policies on nurses with substance use disorders (SUD) on relapse rates and retention in the nursing workforce...
  44. doi Political attitudes vary with physiological traits
    Douglas R Oxley
    Department of Political Science, University of Nebraska Lincoln, Lincoln, NE 68588, USA
    Science 321:1667-70. 2008
  45. ncbi Reducing high-risk drinking by young Americans south of the border: the impact of a partial ban on sales of alcohol
    Robert B Voas
    Pacific Institute for Research and Evaluation, Calverton, Maryland 20705, USA
    J Stud Alcohol 63:286-92. 2002
    ..Determine the effect of a partial sales ban on cross border drinking in Mexico...
  46. ncbi Effect of news coverage on the prevalence of drunk-driving behavior: evidence from a longitudinal study
    Itzhak Yanovitzky
    Department of Communication, School of Communication Information and Library Studies, Rutgers University, New Brunswick, New Jersey 08091 1071, USA
    J Stud Alcohol 63:342-51. 2002
    ..To examine the proposition that antidrunk driving messages in the news media contributed indirectly to the decline in drunk driving over the past two decades through their impact on related policy making processes...
  47. ncbi A partial ban on sales to reduce high-risk drinking South of the border: seven years later
    Robert B Voas
    Pacific Institute for Research and Evaluation, 11710 Beltsville Drive, Suite 125, Calverton, Maryland 20705 3102, USA
    J Stud Alcohol 67:746-53. 2006
    ..The present study's objective was to determine the long-term (7-year) effect of the earlier-closing bar policy on cross-border drinking in Mexico...
  48. pmc The future of tobacco regulation: a response to a proposal for fundamental institutional change
    Jonathan Liberman
    VicHealth Centre for Tobacco Control, The Cancer Council Victoria, 100 Drummond Street, Carlton 3053, Victoria, Australia
    Tob Control 15:333-8. 2006
    ..We should be wary of allowing the understandable allure of new or radical approaches to distract us from this reality...
  49. ncbi Tobacco control in Korea
    Kiljun Park
    College of Law, Yonsei University, Seoul, Korea
    Med Law 23:759-80. 2004
    ..It would be most proper to ratify the FCTC and abolish the Tobacco Business Act. Also, revision of the National Health Promotion Act is necessary to secure the enforcement and implementation of FCTC in Korea...
  50. ncbi [Tobacco control in South Africa]
    Corné van Walbeek
    Ecole d Economie Université du Cap, Afrique du Sud
    Promot Educ . 2005
    ..The legislation clarifies and explains that the rights of non-smokers to clean air supersede the right of smokers to smoke. Smokers typically refrain from smoking where smoking is not allowed...
  51. ncbi Consequences of marketing exceptions in the Master Settlement Agreement: exposure of youth to adult-only tobacco promotions
    Karen Bogen
    Center for Survey Research, University of Massachusetts, Boston, MA 02125, USA
    Nicotine Tob Res 8:467-71. 2006
    ..In light of the large body of evidence that exposure to tobacco advertising and promotion increases tobacco use among youth, our findings demonstrate the need to close the "adult-only" loophole...
  52. ncbi Population receptivity to tobacco advertising/promotions and exposure to anti-tobacco media: effect of Master Settlement Agreement in California: 1992-2002
    Elizabeth A Gilpin
    Department of Family and Preventive Medicine Moores Cancer Center, San Diego, California, USA
    Health Promot Pract 5:91S-98S. 2004
    ..These trends indicate less receptivity to tobacco advertising and promotions following the MSA but leave room for additional restrictions to further reduce receptivity...
  53. ncbi Nanny boo-boos
    John Leo
    US News World Rep 134:12. 2003
  54. ncbi State and federal compliance with the Synar Amendment: federal fiscal year 1998
    J R DiFranza
    Department of Family Medicine and Community Health, 55 Lake Ave, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Arch Pediatr Adolesc Med 155:572-8. 2001
    ..This failure can be attributed to inadequate resources devoted to enforcement and reliance on merchant education in lieu of bona fide law enforcement...
  55. ncbi State tobacco excise taxes and adolescent smoking behaviors in the United States
    Carey Conley Thomson
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
    J Public Health Manag Pract 10:490-6. 2004
    ..These results support the inclusion of tobacco taxes in state tobacco control programs...
  56. ncbi Alcohol-impaired driving and its consequences in the United States: the past 25 years
    Allan F Williams
    J Safety Res 37:123-38. 2006
    ..Progress in dealing with the alcohol-impaired driving problem in the United States during the past 25 years is addressed...
  57. ncbi School smoking bans: do they help/do they harm?
    Christiane C Poulin
    Department of Community Health and Epidemiology, Dalhousie University, Halifax, NS, Canada
    Drug Alcohol Rev 26:615-24. 2007
    ..The purpose of the present study was to examine the association between school smoking bans and smoking initiation as a health outcome as well as academic achievement as an educational outcome, taking into account socio-economic status...
  58. doi School smoking bans
    Raoul A Walsh
    Drug Alcohol Rev 27:570-1. 2008
  59. pmc Aggressive crime, alcohol and drug use, and concentrated poverty in 24 U.S. urban areas
    Avelardo Valdez
    Graduate School of Social Work, University of Houston, Houston, Texas 77204 4013, USA
    Am J Drug Alcohol Abuse 33:595-603. 2007
    ..Our findings tend to counter the cultural theorists who argue for an indigenous culture of violence in inner-city ghettos and barrios...
  60. ncbi Review of what youth programs do to increase the connectedness of youth with adults
    Jean B Grossman
    Woodrow Wilson School, Princeton University, Princeton, New Jersey 08544, USA
    J Adolesc Health 39:788-99. 2006
    ..By connectedness, we mean primarily the attachment youth have to the adults in the programs...
  61. pmc Images in public health
    Robert Sember
    Am J Public Health 93:1626-9. 2003
  62. pmc Overlapping and complementary oxidative stress defense mechanisms in nontypeable Haemophilus influenzae
    Alistair Harrison
    The Center for Microbial Pathogenesis at the Research Institute at Nationwide Children s Hospital and the Center for Microbial Interface Biology and Department of Pediatrics, The Ohio State University, Ohio, USA
    J Bacteriol 197:277-85. 2015
    ..These mechanisms will be important for successful colonization and infection by this opportunistic human pathogen. ..
  63. doi Ctenopharyngodon idella IRF2 plays an antagonistic role to IRF1 in transcriptional regulation of IFN and ISG genes
    Meihui Gu
    Department of Bioscience, College of Life Science, Nanchang University, Nanchang 330031, China
    Dev Comp Immunol 49:103-12. 2015
    ..1-IRF2 and pcDNA3.1-IRF1) were transiently co-transfected with pGL3-IFN or pGL3-CiPKZ into CIK cells, respectively. The results revealed that CiIRF2 plays an antagonistic role to CiIRF1 in transcriptional regulation of IFN and ISG genes...
  64. doi Core promoter short tandem repeats as evolutionary switch codes for primate speciation
    Mina Ohadi
    Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
    Am J Primatol 77:34-43. 2015
    ..We provide evidence of core promoter STRs as evolutionary switch codes for primate speciation, and the first instance of identity-by-descent for those motifs at the interspecies level...
  65. doi Genetic, molecular and clinical determinants for the involvement of aldosterone and its receptors in major depression
    Harald Murck
    Covance Inc, Princeton, N J, USA
    Nephron Physiol 128:17-25. 2014
  66. doi Combined experimental and bioinformatics analysis for the prediction and identification of VHR/DUSP3 nuclear targets related to DNA damage and repair
    Fábio Luís Forti
    Laboratory of Signalling in Biomolecular Systems, Department of Biochemistry, Institute of Chemistry, University of Sao Paulo, Av Prof Lineu Prestes, 748 Bl 09i, Sl 922, CEP 05508 900 Cidade Universitária, Sao Paulo SP, Brazil
    Integr Biol (Camb) 7:73-89. 2015
  67. doi Lipocalin-2 promotes m1 macrophages polarization in a mouse cardiac ischaemia-reperfusion injury model
    L Cheng
    Department of Gynaecology and Obstetrics, Xiangyan Central Hospital, Hubei University of Arts and Science, Xiangyang, China
    Scand J Immunol 81:31-8. 2015
    ..In conclusion, Lcn2 promotes M1 polarization, and Lcn2 neutralization attenuates cardiac IR injury. ..
  68. doi Intestinal ischemic preconditioning ameliorates hepatic ischemia/reperfusion injury in rats: role of heme oxygenase 1 in the second window of protection
    Shoichi Kageyama
    Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan Department of Hepato Biliary Pancreatic and Breast Surgery, Ehime University Graduate School of Medicine, Ehime, Japan
    Liver Transpl 21:112-22. 2015
    ..In conclusion, intestinal RIPC remarkably attenuates hepatic IRI in the SWOP, presumably by HO-1 induction in hepatocytes...
  69. doi Inhibition of protein phosphatase-1 and -2A decreases the chemosensitivity of leukemic cells to chemotherapeutic drugs
    Dóra Dedinszki
    Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
    Cell Signal 27:363-72. 2015
    ..These data imply the importance of PP1 inhibitory proteins in controlling the phosphorylation state of key proteins and regulating drug sensitivity and apoptosis in leukemic cells...
  70. doi Transplantation of human umbilical mesenchymal stem cells attenuates dextran sulfate sodium-induced colitis in mice
    Yan Lin
    Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, China
    Clin Exp Pharmacol Physiol 42:76-86. 2015
    ..These results show that the anti-inflammation and regulation of tight junction proteins by Wharton's jelly-derived UMSC ameliorates colitis. ..
  71. doi Anchorage independency promoted tumor malignancy of melanoma cells under reattachment through elevated interleukin-8 and CXC chemokine receptor 1 expression
    Wu Ching Uen
    aSchool of Medicine, FuJen Catholic University, New Taipei City bDepartment of Hematology and Oncology, Shin Kong Wu Ho Su Memorial Hospital, Taipei cNational Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan
    Melanoma Res 25:35-46. 2015
    ..We show that the suspension of melanoma cells is critical in promoting melanoma malignancy in vivo and in vitro. ..
  72. doi Mineralocorticoid and SGK1-sensitive inflammation and tissue fibrosis
    Ferruh Artunc
    Department of Internal Medicine, University of Tubingen, Tubingen, Germany
    Nephron Physiol 128:35-9. 2014
    ..The untoward inflammatory and fibrosing effects of mineralocorticoids could be blunted or even reversed by mineralocorticoid receptor blockers, which may thus be considered in the treatment of inflammatory and/or fibrosing disease...
  73. doi ATF3-mediated NRF2/HO-1 signaling regulates TLR4 innate immune responses in mouse liver ischemia/reperfusion injury
    J Rao
    Liver Transplantation Center of First Affiliated Hospital and Translational Medicine Research Center of Jiangning Hospital, Nanjing Medical University, Nanjing, P R China Key Laboratory of Living Donor Liver Transplantation of Ministry of Public Health, Nanjing, P R China Division of Liver and Pancreas Transplantation, Department of Surgery, Dumont UCLA Transplant Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA
    Am J Transplant 15:76-87. 2015
    ..Our findings provide a rationale for a novel therapeutic strategy for managing IR-induced liver injury. ..
  74. doi Upregulation of FLJ10540, a PI3K-association protein, in rostral ventrolateral medulla impairs brain stem cardiovascular regulation during mevinphos intoxication
    Ching Yi Tsai
    Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan, Republic of China
    Biochem Pharmacol 93:34-41. 2015
  75. doi On the pleotropic actions of mineralocorticoids
    Florian Lang
    Department of Physiology, Eberhard Karls University of Tubingen, Tubingen, Germany
    Nephron Physiol 128:1-7. 2014
    ..Clearly, still much is to be learned about the various ramifications of mineralocorticoid-sensitive physiology and pathophysiology...
  76. doi Sex-dependent regulation of hepatic CYP3A by growth hormone: Roles of HNF6, C/EBPα, and RXRα
    Jie Li
    Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, China
    Biochem Pharmacol 93:92-103. 2015
    ..RXRα mediates the sex-dependent influence of GH on CYP3A expression as an important signalling molecule. ..
  77. doi Effect of mineralocorticoids on acid-base balance
    Carsten A Wagner
    Institute of Physiology, University of Zurich, Zurich, Switzerland
    Nephron Physiol 128:26-34. 2014
    ..In patients with CKD, acidosis-induced aldosterone may contribute to progression of kidney disease. In summary, aldosterone is a powerful regulator of renal acid excretion required for normal acid-base balance...
  78. pmc Combinatorial regulation of the dev operon by MrpC2 and FruA during Myxococcus xanthus development
    Ashleigh Campbell
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, USA
    J Bacteriol 197:240-51. 2015
    ..This site is unique among the C-signal-dependent genes studied so far. Deletion of this site in the M. xanthus chromosome did not impair sporulation under laboratory conditions. ..
  79. doi Evaluation of developmental toxicity using undifferentiated human embryonic stem cells
    Eui Man Jung
    Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, 361 763, Republic of Korea
    J Appl Toxicol 35:205-18. 2015
    ..Therefore, we suggest that hES cells may be useful for testing the toxic effects of chemicals that could impact the embryonic developmental stage...
  80. pmc Deregulation of Rb-E2F1 axis causes chromosomal instability by engaging the transactivation function of Cdc20-anaphase-promoting complex/cyclosome
    Somsubhra Nath
    Cancer Biology and Inflammatory Disorder Division, CSIR Indian Institute of Chemical Biology, Kolkata, India
    Mol Cell Biol 35:356-69. 2015
    ..We conclude that excess E2F1 due to Rb inactivation recruits the complex of Cdc20 and the anaphase-promoting complex/cyclosome (Cdc20-APC/C) to deregulate the expression of UBCH10, leading to chromosomal instability in cancer cells. ..
  81. doi Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells
    Sara Bursomanno
    Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Panum Institute, DK 2200 Copenhagen, Denmark
    DNA Repair (Amst) 25:84-96. 2015
  82. doi Active heat shock transcription factor 1 supports migration of the melanoma cells via vinculin down-regulation
    Agnieszka Toma-Jonik
    Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Wybrzeze Armii Krajowej 15, 44 101 Gliwice, Poland Electronic address
    Cell Signal 27:394-401. 2015
    ..An apparent association between HSF1-induced down-regulation of vinculin, increased motility, and a reduced adherence of cells suggests a possible mechanism of HSF1-mediated enhancement of the metastatic potential of cancer cells...
  83. pmc Glutamate-induced apoptosis in primary cortical neurons is inhibited by equine estrogens via down-regulation of caspase-3 and prevention of mitochondrial cytochrome c release
    YueMei Zhang
    Department of Obstetrics and Gynecology, University of Toronto, Toronto, Canada
    BMC Neurosci 6:13. 2005
  84. doi The role of CT10 regulation of kinase-like in cancer
    Chunmei Guo
    Department of Biotechnology, Dalian Medical University, Dalian, China
    Future Oncol 10:2687-97. 2014
    ..The association of CRKL with malignant tumors and its potential action mechanisms were summarized. CRKL has the potential to be used as a biomarker for the diagnosis, treatment and prognosis of certain tumors...
  85. doi Cholecystokinin regulates satiation independently of the abdominal vagal nerve in a pig model of total subdiaphragmatic vagotomy
    D Ripken
    Top Institute of Food and Nutrition, Nieuwe Kanaal 9A, Wageningen, The Netherlands The Netherlands Organization for Applied Scientific Research, TNO, Zeist, The Netherlands Division of Human Nutrition, Wageningen University, Bomenweg 2, Wageningen, The Netherlands Electronic address
    Physiol Behav 139:167-76. 2015
    ..We conclude that regulation of liquid meal intake appears to be primarily regulated by CCK1 receptors not located on abdominal vagal nerve endings...
  86. doi The role of gut hormones in appetite regulation (review)
    G Marić
    University of Belgrade Institute of Epidemiology, Faculty of Medicine Belgrade Serbia
    Acta Physiol Hung 101:395-407. 2014
  87. doi Acp70A regulates Drosophila pheromones through juvenile hormone induction
    Gwénaëlle Bontonou
    CNRS UPR 9034, Universite de Paris Sud, 91198 Gif sur Yvette, France
    Insect Biochem Mol Biol 56:36-49. 2015
    ..Mating had negligible effects on CHC levels, however pheromone amounts were slightly reduced 3 and 4 days post copulation. The physiological significance of ACP70A on female pheromone synthesis is discussed...
  88. doi The repair of oxidized purines in the DNA of human lymphocytes requires an activation involving NF-YA-mediated upregulation of OGG1
    Carina von der Lippen
    Institute of Pharmacy and Biochemistry, University of Mainz, Staudingerweg 5, D 55099 Mainz, Germany
    DNA Repair (Amst) 25:1-8. 2015
    ..Our results reveal a strict control of base excision repair in cells of the human immune system. ..
  89. doi Leptin enhances endothelial cell differentiation and angiogenesis in murine embryonic stem cells
    Silvia Kurtovic
    Comprehensive Transplant Center, Department of Surgery, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    Microvasc Res 97:65-74. 2015
    ..Leptin-mediated EC differentiation and angiogenesis in ESCs can be a useful application towards regenerative medicine and tissue engineering. ..
  90. doi AEG-1 3'-untranslated region functions as a ceRNA in inducing epithelial-mesenchymal transition of human non-small cell lung cancer by regulating miR-30a activity
    Kunmei Liu
    School of Life Science and Technology, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 210009 Nanjing, China Ningxia Key Laboratory of Cerebrocranial Diseases, School of Laboratory Medicine, Ningxia Medical University, Yinchuan 750004, China
    Eur J Cell Biol 94:22-31. 2015
    ..In conclusion, our findings demonstrated a competitive endogenous RNAs regulatory network which will help understand the metastasis mechanisms of lung cancer and improve the prevention and treatment of lung cancer. ..
  91. doi Spatial analysis of gene regulation reveals new insights into the molecular basis of upper thermal limits
    Marina Telonis-Scott
    School of Biological Sciences, Monash University, Clayton, Vic, 3800, Australia
    Mol Ecol 23:6135-51. 2014
    ..Innate and induced transcriptome responses to hyperthermia are complex, and warrant moving beyond gene-level analyses. ..
  92. doi Dieckol enhances the expression of antioxidant and detoxifying enzymes by the activation of Nrf2-MAPK signalling pathway in HepG2 cells
    Min Sup Lee
    Department of Food Science and Nutrition, Pukyong National University, Busan 608 737, South Korea
    Food Chem 174:538-46. 2015
  93. pmc Estrogen mediated epithelial proliferation in the uterus is directed by stromal Fgf10 and Bmp8a
    Daesuk Chung
    Division of Reproductive Sciences, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Mol Cell Endocrinol 400:48-60. 2015
    ..Overall, stromal Fgf10 and Bmp8a serve as potential paracrine factors for E2-dependent regulation of epithelial proliferation in the uterus. ..
  94. ncbi D-Serine exposure resulted in gene expression changes indicative of activation of fibrogenic pathways and down-regulation of energy metabolism and oxidative stress response
    Armando Soto
    Applied Biotechnology Branch, Division of Biosciences and Protection, Human Effectiveness Directorate, Air Force Research Laboratory, Area B, Wright Patterson Air Force Base, Dayton, OH 45433 5707, USA
    Toxicology 243:177-92. 2008
    ..Taken together, the results of this study provide important insights into the molecular mechanism of D-serine nephrotoxicity, as well as the activation of specific cellular pathways in response to this toxic insult...
  95. pmc MicroRNA-regulation of Anopheles gambiae immunity to Plasmodium falciparum infection and midgut microbiota
    Nathan J Dennison
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Dev Comp Immunol 49:170-8. 2015
    ..Our study shows that A. gambiae aga-miR-305 regulates the anti-Plasmodium response and midgut microbiota, likely through post-transcriptional modification of immune effector genes...
  96. pmc Blood-brain barrier KCa3.1 channels: evidence for a role in brain Na uptake and edema in ischemic stroke
    Yi Je Chen
    From the Department of Pharmacology Y J C, D P J, H W and Department of Physiology and Membrane Biology B K W, N Y, M E O, University of California, Davis
    Stroke 46:237-44. 2015
    ..This study evaluated whether KCa3.1 is expressed on and participates in BBB ion transport...
  97. pmc Heat stress-induced Cup9-dependent transcriptional regulation of SIR2
    Shyamasree Laskar
    Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, India
    Mol Cell Biol 35:437-50. 2015
    ..The results of our study highlight the mechanism by which environmental factors amend the epigenetic configuration of chromatin. ..
  98. pmc A developmentally inspired combined mechanical and biochemical signaling approach on zonal lineage commitment of mesenchymal stem cells in articular cartilage regeneration
    Tahereh Karimi
    Biomimetic Materials and Tissue Engineering Laboratory, Department of Chemical Engineering, University of South Carolina, Swearingen Engineering Center, Rm 2C11, Columbia, SC 29208, USA
    Integr Biol (Camb) 7:112-27. 2015
    ..Results demonstrate that a developmental approach with gradients in cell density, matrix stiffness, and zone-specific growth factors can potentially regenerate zonal structure of the articular cartilage. ..
  99. pmc Tumor necrosis factor-α-accelerated degradation of type I collagen in human skin is associated with elevated matrix metalloproteinase (MMP)-1 and MMP-3 ex vivo
    Magnus S AGren
    Copenhagen Wound Healing Center, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark Digestive Disease Center, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Electronic address
    Eur J Cell Biol 94:12-21. 2015
    ..TNF-α had no significant effect on epidermal apoptosis. Our data indicate that TNF-α augments collagenolytic activity of MMP-1, possibly through up-regulation of MMP-3 leading to gradual loss of type I collagen in human skin. ..
  100. pmc Regulation of MAP kinase signaling cascade by microRNAs in Oryza sativa
    Badmi Raghuram
    a National Institute of Plant Genome Research New Delhi, India
    Plant Signal Behav 9:e972130. 2014
    ..Taken together, this report demonstrates the significance of miRNAs in regulation of the MAPK pathway in plants with a new direction to study the plant signaling molecules. ..
  101. doi Differential epithelial and stromal protein profiles in keratoconus and normal human corneas
    R Joseph
    Department of Vision Sciences, University of Alabama at Birmingham, 924 18th Street South, Birmingham, AL 35294 4390, USA
    Exp Eye Res 92:282-98. 2011
    ..Additionally, because several epithelial and stromal enzymes exhibited up- or down-regulation in the KC corneas relative to normal corneas, the two layers of KC corneas were under metabolic stress to adjust their remodeling...

Research Grants110 found, 100 shown here

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  3. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  4. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  5. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  6. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  7. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
  8. Transcription factors regulating sensory gene expression and pain pathways
    Eric E Turner; Fiscal Year: 2011
    ..Together these studies will significantly advance our understanding of the molecular regulation of pain receptor pathways, which may form the basis for future pain treatments. ..
  9. Xenoestrogen regulation of Leydig cells
    ..Research training to be afforded by the present application to professional veterinary students will contribute to efforts geared to preparing future veterinarians to meet these challenges. ..
  10. Lauren Endres; Fiscal Year: 2014
    ..Overall, these findings will form the basis of future studies into Abh8 regulation during the DDR. ..
  11. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert A Harris; Fiscal Year: 2012
    ..We therefore believe the proposed work has the potential to have a significant impact on the health care of Veterans. ..
  12. SHAOCHUNG VICTOR HSIA; Fiscal Year: 2016
    ..The long-term goal is to identify the regulatory mechanisms to assist in the development of novel therapeutic protocols for better treatments. ..
  13. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
    ..However, curcumin has been effective in tumors, such as colon and HNC, where direct access to the drug is possible. The primary aim of this study is to develop curcumin as a chemotherapeutic and radiation sensitizer for treating HNC.. ..
  14. Mapping for Specialized Domains for FCeRI Signaling &Internalization
    Bridget S Wilson; Fiscal Year: 2013
    ..Results of these analyses will contribute important new insight into the nature and assembly of membrane microdomains controlling immune cell signaling. ..
  15. MERVYN N WEITZMANN; Fiscal Year: 2016
  16. Yun Fai Chris Lau; Fiscal Year: 2014
    ..This project will shed important insights on how the Y-oncogene and X-tumor suppressor operate and how one can interfere or boost their actions respectively to treat prostate cancer. ..
  17. The Primate Corpus Luteum: Functional Regression and Cardiovascular Impacts
    Randy L Bogan; Fiscal Year: 2012
    ..abstract_text> ..
  18. Jill M Wecht; Fiscal Year: 2014
  19. Tibor T Glant; Fiscal Year: 2016
  20. Carole R Mendelson; Fiscal Year: 2016
  21. PHILIP LEE JOHNSON; Fiscal Year: 2016
    ..This will allow me to make significant contributions to our knowledge of the neural and neurochemical mechanisms that lead to hot flashes and to identify potential novel nonhormonal targets for treatment. ..
  22. The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intake
    NILS WG LAMBRECHT; Fiscal Year: 2012
    ..The proposed studies will address important pathophysiological questions regarding the mechanisms regulating appetite and satiety as well as provide potentially important clinical treatment strategies. ..
  23. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2012
    ..In the future, individual patients with variation in these genes may benefit from targeted behavioral and/or pharmacological interventions designed to improve their health. ..
  24. Role of Chromogranin A in Metabolic Syndrome
    Sushil K Mahata; Fiscal Year: 2013
    ..2. Evaluate the potential therapeutic effects of CST and its variants on insulin sensitivity and baroreflex sensitivity and heart rate variability in high fat diet-induced insulin resistant and in db/db diabetic mice. ..
  26. FASEB SRC on Lysophospholipd Mediators in Health and Disease
    Julie D Saba; Fiscal Year: 2011
  27. KRISTEN RACHEL VELLA; Fiscal Year: 2014
    ..abstract_text> ..
  28. Targeting Galectin-3 with novel drugs for treatment of eczema
    Fu Tong Liu; Fiscal Year: 2010
    ..We hope the proposed studies will definitively validate galectin-3 as a target for treating atopic dermatitis and lead to the development of a novel therapy for this disease. ..
  29. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
    ..The proposed experiments will determine in animal models the efficacy and mechanisms of action responsible for the antifibrotic effects of ajulemic acid (AJA). ..
  30. CRF-Oxytocin Interaction in the Regulation of Stress and Affect
    Joanna Dabrowska; Fiscal Year: 2013
    ..My career objective is to conduct independent research to understand how stress and affect interact and elucidate their respective roles in the etiology of mental disorders like depression and anxiety. ..
  31. Patrice G Guyenet; Fiscal Year: 2015
    ..This research focuses on specific neuronal networks located in the lower part of the brain called the medulla oblongata and its ultimate goal is to uncover novel treatments for OSA and other sleep-related respiratory disorders. ..
  32. Discovery of Small Molecule MBT Domain Antagonists
    STEPHEN VERNON FRYE; Fiscal Year: 2010
    ..The chemical probes designed, synthesized and validated in this proposal will have applications in the discovery of molecular targets to treat diseases such as cancer and in the development of safe stem cell based therapeutics. ..
  33. Agrin/alpha 3 Na,K-ATPase signaling at the neuromuscular junction
    Martin A Smith; Fiscal Year: 2012
    ..This novel signal pathway represents a new therapeutic target for the treatment of neuromuscular disease. ..
  34. Regulation of B Cell Function by Membrane-Cytoskeletal Remodeling
    Neetu Gupta; Fiscal Year: 2012
    ..Lessons learnt from understanding the role of ezrin in B cell function can be applied towards therapeutic design for B cell-dependent human diseases. ..
  35. Role of Txnip in adapting fuel metabolism to nutritional state
    SIMON HUI; Fiscal Year: 2013
    ..Results of this proposed research will provide fundamental information that may lead to better prevention and/or therapeutics for diabetes and cardiovascular disease in humans. ..
  36. Stephen E McGowan; Fiscal Year: 2016
    ..These studies are relevant to other vascular diseases including stroke, diabetes, and chronic renal insufficiency, which are also common among veterans. ..
  37. Impact of the P479L Variant in CPT1A on Infant Mortality in Alaska
    David M Koeller; Fiscal Year: 2011
    ..The results of this study will aid in the development of evidence-based guidelines for the treatment of Alaska Native infants diagnosed with CPT1A deficiency by newborn screening. ..
  38. The role of Fli1 in T cell function and the pathogenesis of lupus
    Tamara K Nowling; Fiscal Year: 2011
    ..Additionally, insight will be gained into the regulation of T cell function in both health and disease with relevance to an array of immune and neoplastic diseases. ..
  39. Randal J Kaufman; Fiscal Year: 2014
    ..The proposed studies on protein synthesis will provide vital information that should encourage the development of novel therapeutics to treat diabetes. ..
  40. Role of SCD1 and Dietary Methionine Restriction on Energy Homeostasis
    ERIC PAUL PLAISANCE; Fiscal Year: 2011
  41. Lung Lysyl Oxidase Regulation by Metal Ion Homeostasis
    Wande Li; Fiscal Year: 2013
    ..The outcomes of the proposed research are expected to enhance our understanding of mechanisms of LO gene silence by Cd providing the basis for developing prophylaxis and treatment strategies for Cd-related lung diseases. ..
    Melanie H Cobb; Fiscal Year: 2012
    ..Understanding the mechanisms of action of this family will provide significant insights into the control of ion balance and other essential processes, and may reveal novel strategies to develop anti-hypertensive therapies. ..
  43. Genetics and Haloperidol Response
    Robert J Hitzemann; Fiscal Year: 2012
  44. RALPH FRANK FREGOSI; Fiscal Year: 2016
    ..It is therefore crucial to begin establishing the mechanisms that lead to abnormal development of the brainstem neurons that regulate these critical homeostatic functions. ..
  45. Michael Demetriou; Fiscal Year: 2014
    ..Here we further explore the mechanisms by which protein glycosylation regulates immune function and autoimmunity. ..
  46. Samantha M Yeligar; Fiscal Year: 2014
    ..Thus, this K99/R00 application provides an excellent opportunity to advance the career of a talented and promising investigator. ..
  47. Bayar Thimmapaya; Fiscal Year: 2016
  48. Translational Machinery in Stress Signaling and Tumor Suppression
    THOMAS J contact BEGLEY; Fiscal Year: 2010
    ..The long term potential of the proposed research is significant, as understanding the mechanisms by which TRM9 inhibits tumor growth may provide novel therapeutic opportunities to restore growth-restricting programs in cancer cells. ..
  49. Role of Polyamines in MYCN-Amplified Neuroblastoma
    ANDRE BACHMANN; Fiscal Year: 2009
    ..Our research will be useful in the development of novel treatments for the most aggressive forms of the childhood cancer neuroblastoma. ..
  50. Patient-Derived Stem Cells for Phosphoproteomic Profiling Neuropsychopathology
    Dieter A Wolf; Fiscal Year: 2011
  51. Mark W Chapleau; Fiscal Year: 2015
    ..Inhibition of Ang II-mediated effects by activation of CGRP/RAMP1 receptors has widespread implications in hypertension and heart failure. ..
  52. Mitchell Kronenberg; Fiscal Year: 2014
    ..This proposal will study the mechanisms by which the immune responses are properly controlled. Such knowledge will eventually facilitate the design of novel therapeutic approaches for immunological diseases. ..
  53. Donald A McClain; Fiscal Year: 2016
    ..Initial exploration of mechanisms will include altered heme and NAD levels, the latter resulting in altered AMPK signaling. ..
  54. Insulin Signaling and the Heart in Diabetes
    EVAN DALE ABEL; Fiscal Year: 2011
    ..Moreover, elucidation of the signaling mechanisms that regulate autophagy in cardiomyocytes may lead to novel therapies for preventing or modulating heart injury as occurs in diabetes, cardiac ischemia or cardiac hypertrophy. ..
  55. Biology and Pathologies of Type V Collagen
    Daniel S Greenspan; Fiscal Year: 2013
    ..If such studies are borne out, the ramifications are huge, with profound implications for understanding, evaluating and treating atherosclerotic disease - the number one killer of adult human beings in the western hemisphere. ..
  56. Collagen X and heparan sulfate proteoglycan in the hematopoietic stem cell niche.
    ELIZABETH G SWEENEY; Fiscal Year: 2012
    ..Cancro and Akintoe (my collaborators), and the numerous faculty members that I will interact with at the many journal club, seminar, and symposiums offered at Penn and the surrounding schools. ..
  57. Paul E Micevych; Fiscal Year: 2016
    ..This type of infertility exhibits excess estrogen production without ovulation that can lead to polycystic ovary syndrome, irregular vaginal bleeding, metabolic abnormalities as well as endometrial polyps, hyperplasia, and even cancer. ..
    RUTH M STEWARD; Fiscal Year: 2010
    ..We are aiming at developing a PCR approach to differentiate between the forms of PDCD2 found in normal bone marrow and blood, and the PDCD2 forms associated with leukemic cells. ..
  59. Role of IKK in NSCLC: Modulation of SMRT and NF-kappaB
    Marty W Mayo; Fiscal Year: 2012
    ..The overall goal of this project is use these newly identified gene products as novel therapeutic targets for detection and treatment of NSCLC. ..
  60. DNA methylation of extracellular superoxide dismutase in pulmonary hypertension
    EVA NOZIK GRAYCK; Fiscal Year: 2012
    ..abstract_text> ..
  61. David A Bernlohr; Fiscal Year: 2014
    ..If the hypothesis is proven to be correct, the study would be immediately translatable to human biology and afford a new view of how type 2 diabetes may be combated. ..
  62. Rac GTPase signaling during embryonic salivary gland branching morphogenesis
    Sharon Sequeira; Fiscal Year: 2012
  63. Junxuan Lu; Fiscal Year: 2014
    ..These multiple targeting activities plus published work supporting anti- angiogenesis activity provide strong rationale for testing the efficacy of PGG for prostate cancer chemoprevention. ..
  64. Maria Diakonova; Fiscal Year: 2014
    ..Understanding how these proteins work together will help to design new therapeutic approaches and possibly drugs for treatment of different human diseases and breast cancer. ..
  65. Jianming Qiu; Fiscal Year: 2016
    ..e., EPCs ex vivo-expanded under hypoxic conditions for B19V in this application. ..
  66. UTPAL BHAGIRATH PAJVANI; Fiscal Year: 2015
    ..Pajvani will need in order to become an independent translational medical researcher and a productive member of the academic medical community. ..
  67. Analysis of gene regulation of Vibrio cholerae during infection
    Jun Zhu; Fiscal Year: 2013
    ..cholerae in vivo survival strategies and shed new light on the host-pathogen interactions that underpin infections by related enteric bacterial pathogens. ..
  68. Christie P Thomas; Fiscal Year: 2014
  69. Howard B Lieberman; Fiscal Year: 2016
  70. ELIZABETH ANN EKLUND; Fiscal Year: 2016
    ..Targeting these mechanisms may lead to cure in CML by abolishing the CSC/LSC, and suggest therapeutic approaches to other forms of cancer with dysregulation of Fas and bcatenin. ..
  71. Rebecca A Simmons; Fiscal Year: 2016
    ..The proof of the principle of prenatal programming by environmental contaminants may change our awareness of critical assessment of the risk of such compounds. ..
  72. Vickram Ramkumar; Fiscal Year: 2016
    ..Overall, we believe that this study will provide the basis for the use of transplatin to alleviate cisplatin toxicities in cancer patients. ..
  73. Chou Zen Giam; Fiscal Year: 2014
    ..The study will provide molecular insights that can lead to the development of treatment strategies for human cancer ..
  74. Christin Carter-Su; Fiscal Year: 2016
  75. RSK-2 regulates integrin-mediated adhesion and migration
    JOE WILLIAM RAMOS; Fiscal Year: 2013
    ..This will determine if these proteins are suitable targets for the development of new adhesion specific disease therapies. In particular we will test if RSK2 can serve as a potential new therapeutic target in glioma. ..
  76. Zhou Wang; Fiscal Year: 2014
  77. SAMUEL BRANDON STEPHENS; Fiscal Year: 2015
    ..Thus, through this award, I will gain training and generate crucial reagents necessary to launch my independent research program and obtain a tenure-track assistant professorship. ..
  78. Richard J Bram; Fiscal Year: 2015
    ..These compounds will ultimately lead to establishing a novel approach for therapeutic treatment of GBM. In addition, they will have great utility as molecular probes to enhance studies defining the critical functions of CypB. ..
  79. ERIC KIRK LAU; Fiscal Year: 2014
    ..abstract_text> ..
  80. Moosa Mohammadi; Fiscal Year: 2016
    ..Since substrate recruitment and phosphorylation by RTKs is a general event in RTK signaling, the mechanistic insights gained under Aim IV will also be directly applicable to the entire RTK superfamily. ..
  81. John R Grider; Fiscal Year: 2016
    ..The results would open a new field of study and point the way to new avenues of investigation for pharmacological agents to treat diarrhea and/or constipation. ..
  82. Claire Larmonier; Fiscal Year: 2014
    ..Those specific aims will help address the following hypothesis: PARP1 contributes to aggravated mucosal immune response via modulation of inflammatory signaling pathways within the cells of the innate immune system. ..
  83. CLIFFORD JAMES ROSEN; Fiscal Year: 2015
    ..Importantly, these studies will shed new light on the ErbB and Dock7 signaling pathways in bone and in BAT. Defining shared metabolic-skeletal networks may lead to new treatments for age-related osteoporosis. ..
  84. Heather R Burkin; Fiscal Year: 2015
    ..Defining the integrin- mediated signaling pathways that regulate stretch induced activation of the uterine myometrium will have important implications for treating preterm and post term labor. ..
  85. Leena A Hilakivi-Clarke; Fiscal Year: 2015
  86. Jeanette Gowen Cook; Fiscal Year: 2016
  87. Paul M Lieberman; Fiscal Year: 2016
    ..More detailed understanding of EBNA1 is further justified by its potential value as a target for therapeutic intervention in diseases and cancers associated with EBV latent infection. ..
  88. ALBERT HONG JAE KIM; Fiscal Year: 2016
  89. ANASTACIA GRIEGO; Fiscal Year: 2016
    ..Additionally, we will have learned critical aspects of the interplay between host and virus that may underlie progression to cancer and/or prognosis of HPV[+] lesions. ..
  90. Sihem Boudina; Fiscal Year: 2016
    ..abstract_text> ..
  91. Identifying underlying mechanisms of intracellular changes in response to caregiv
    MELANIE SARAH FLINT; Fiscal Year: 2013
    ..The data obtained will be critical in identifying caregivers at risk for negative outcomes to improve overall caregiver health. ..
  92. Alexandra M Machikas; Fiscal Year: 2014
    ..The findings from this study will be invaluable in establishing the phenotype of cell death characteristic of I/R injury in the aged female heart and may supply clear evidence of the mitochondria as a therapeutic target for AMI. ..
  93. KEVIN P CURRIE; Fiscal Year: 2014
    ..This will provide the foundation for future expanded applications to investigate a new paradigm for 5HT / SERT mediated signal transduction. ..
  94. Paul Sumby; Fiscal Year: 2014
    ..Public health may be enhanced through the long-term goal of translating knowledge of FASX regulatory pathways into new treatment and/or preventative regimes based upon the inhibition of these pathways by novel antimicrobial agents. ..