primary prevention

Summary

Summary: Specific practices for the prevention of disease or mental disorders in susceptible individuals or populations. These include HEALTH PROMOTION, including mental health; protective procedures, such as COMMUNICABLE DISEASE CONTROL; and monitoring and regulation of ENVIRONMENTAL POLLUTANTS. Primary prevention is to be distinguished from secondary prevention, which is the prevention of complications or after-effects of a drug or surgical procedure, and tertiary prevention, the amelioration of the after-effects of a disease.

Top Publications

  1. ncbi Primary prevention of cardiovascular disease with a Mediterranean diet
    Ramon Estruch
    Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain
    N Engl J Med 368:1279-90. 2013
  2. ncbi Guidelines for the primary prevention of stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association
    Larry B Goldstein
    American Heart Association American Stroke Association
    Stroke 42:517-84. 2011
  3. pmc Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials
    Colin Baigent
    CTSU, Oxford University, Oxford, UK
    Lancet 373:1849-60. 2009
  4. ncbi Statins for the primary prevention of cardiovascular disease
    Fiona Taylor
    Department of Non communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK
    Cochrane Database Syst Rev 1:CD004816. 2013
  5. pmc Moving towards a population health approach to the primary prevention of common mental disorders
    Felice N Jacka
    Deakin University, School of Medicine and Barwon Health, PO Box 281, Geelong 3220, Australia
    BMC Med 10:149. 2012
  6. ncbi Primary prevention of hypertension: clinical and public health advisory from The National High Blood Pressure Education Program
    Paul K Whelton
    Department of Epidemiology and Medicine, Tulane University Health Sciences Center, Tulane University, New Orleans, LA, USA
    JAMA 288:1882-8. 2002
  7. ncbi Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial
    I Min Lee
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    JAMA 294:56-65. 2005
  8. pmc Primary prevention of colorectal cancer
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 138:2029-2043.e10. 2010
  9. pmc Aspirin for primary prevention of cardiovascular events in people with diabetes: meta-analysis of randomised controlled trials
    Giorgia De Berardis
    Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, Via Nazionale 8 A, 66030 S Maria Imbaro, Italy
    BMJ 339:b4531. 2009
  10. pmc The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease
    JoAnn E Manson
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, United States
    Contemp Clin Trials 33:159-71. 2012

Detail Information

Publications354 found, 100 shown here

  1. ncbi Primary prevention of cardiovascular disease with a Mediterranean diet
    Ramon Estruch
    Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain
    N Engl J Med 368:1279-90. 2013
    ..We conducted a randomized trial of this diet pattern for the primary prevention of cardiovascular events.
  2. ncbi Guidelines for the primary prevention of stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association
    Larry B Goldstein
    American Heart Association American Stroke Association
    Stroke 42:517-84. 2011
    ..This guideline provides an overview of the evidence on established and emerging risk factors for stroke to provide evidence-based recommendations for the reduction of risk of a first stroke...
  3. pmc Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials
    Colin Baigent
    CTSU, Oxford University, Oxford, UK
    Lancet 373:1849-60. 2009
    Low-dose aspirin is of definite and substantial net benefit for many people who already have occlusive vascular disease. We have assessed the benefits and risks in primary prevention.
  4. ncbi Statins for the primary prevention of cardiovascular disease
    Fiona Taylor
    Department of Non communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK
    Cochrane Database Syst Rev 1:CD004816. 2013
    ..Previous reviews of the effects of statins have highlighted their benefits in people with CVD. The case for primary prevention was uncertain when the last version of this review was published (2011) and in light of new data an update ..
  5. pmc Moving towards a population health approach to the primary prevention of common mental disorders
    Felice N Jacka
    Deakin University, School of Medicine and Barwon Health, PO Box 281, Geelong 3220, Australia
    BMC Med 10:149. 2012
    ....
  6. ncbi Primary prevention of hypertension: clinical and public health advisory from The National High Blood Pressure Education Program
    Paul K Whelton
    Department of Epidemiology and Medicine, Tulane University Health Sciences Center, Tulane University, New Orleans, LA, USA
    JAMA 288:1882-8. 2002
    ..The National High Blood Pressure Education Program Coordinating Committee published its first statement on the primary prevention of hypertension in 1993...
  7. ncbi Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial
    I Min Lee
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    JAMA 294:56-65. 2005
    ..Randomized trials do not generally support benefits of vitamin E, but there are few trials of long duration among initially healthy persons...
  8. pmc Primary prevention of colorectal cancer
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 138:2029-2043.e10. 2010
    ..Taken together, modifications in diet and lifestyle should substantially reduce the risk of colorectal cancer and could complement screening in reducing colorectal cancer incidence...
  9. pmc Aspirin for primary prevention of cardiovascular events in people with diabetes: meta-analysis of randomised controlled trials
    Giorgia De Berardis
    Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, Via Nazionale 8 A, 66030 S Maria Imbaro, Italy
    BMJ 339:b4531. 2009
    ..To evaluate the benefits and harms of low dose aspirin in people with diabetes and no cardiovascular disease...
  10. pmc The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease
    JoAnn E Manson
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, United States
    Contemp Clin Trials 33:159-71. 2012
    ..vitamin D and marine omega-3 fatty acids may reduce risk for cancer or cardiovascular disease (CVD), but primary prevention trials with adequate dosing in general populations (i.e., unselected for disease risk) are lacking...
  11. pmc Primary care: is there enough time for prevention?
    Kimberly S H Yarnall
    Department of Community and Family Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Public Health 93:635-41. 2003
    ..We sought to determine the amount of time required for a primary care physician to provide recommended preventive services to an average patient panel...
  12. pmc A pilot study of emollient therapy for the primary prevention of atopic dermatitis
    Eric L Simpson
    Department of Dermatology, Oregon Health and Science University, Portland, Oregon 97239 4501, USA
    J Am Acad Dermatol 63:587-93. 2010
    ..New research reveals the importance of the skin barrier in the development of AD and possibly food allergy and asthma. Correcting skin barrier defects from birth may prevent AD onset or moderate disease severity...
  13. ncbi Primary prevention of cardio-metabolic diseases in general practice: a Dutch survey of attitudes and working methods of general practitioners
    Markus M J Nielen
    NIVEL Netherlands Institute for Health Services Research, Utrecht, The Netherlands
    Eur J Gen Pract 16:139-42. 2010
    To study the attitudes and working methods of general practitioners (GPs) in primary prevention of cardiovascular diseases, diabetes mellitus and chronic kidney diseases.
  14. ncbi Physical activity during leisure time and primary prevention of coronary heart disease: an updated meta-analysis of cohort studies
    Francesco Sofi
    Department of Medical and Surgical Critical Care, Thrombosis Centre, Azienda Ospedaliero Universitaria Careggi, University of Florence, Florence, Italy
    Eur J Cardiovasc Prev Rehabil 15:247-57. 2008
    ..The real magnitude of the association between physical activity during leisure time (LTPA) and primary prevention of coronary heart disease (CHD) has, however, not been completely defined.
  15. pmc Primary prevention of gestational diabetes mellitus and large-for-gestational-age newborns by lifestyle counseling: a cluster-randomized controlled trial
    Riitta Luoto
    UKK Institute for Health Promotion Research, Tampere, Finland
    PLoS Med 8:e1001036. 2011
    ..Our objective was to examine whether gestational diabetes mellitus (GDM) or newborns' high birthweight can be prevented by lifestyle counseling in pregnant women at high risk of GDM...
  16. pmc Primary prevention of overweight in children and adolescents: a meta-analysis of the effectiveness of interventions aiming to decrease sedentary behaviour
    Amy van Grieken
    Department of Public Health, Erasmus MC, University Medical Center, P, O, Box 2040, 3000 CA, Rotterdam, The Netherlands
    Int J Behav Nutr Phys Act 9:61. 2012
    ..Studies need to increase follow-up time to estimate the sustainability of the intervention effects found...
  17. ncbi Randomized, double-blind, placebo-controlled trial of probiotics for primary prevention: no clinical effects of Lactobacillus GG supplementation
    Matthias Volkmar Kopp
    University Children s Hospital, Mathildenstrasse 1, D 79106 Freiburg, Germany
    Pediatrics 121:e850-6. 2008
    The value of probiotics for primary prevention is controversial. Published trials vary considerably in study design and the applied probiotics, thereby limiting comparability of the results.
  18. ncbi Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
    M Kalliomaki
    Department of Paediatrics, University of Turku and Turku University Hospital, Finland
    Lancet 357:1076-9. 2001
    ..We assessed the effect on atopic disease of Lactobacillus GG (which is safe at an early age and effective in treatment of allergic inflammation and food allergy)...
  19. ncbi Effect of aspirin on mortality in the primary prevention of cardiovascular disease
    Nina Raju
    Haematology Unit, Queensland Pathology and Department of Internal Medicine, Prince Charles Hospital, Brisbane, Australia
    Am J Med 124:621-9. 2011
    The lack of a mortality benefit of aspirin in prior meta-analyses of primary prevention trials of cardiovascular disease has contributed to uncertainty about the balance of benefits and risks of aspirin in primary prevention...
  20. ncbi Implementation of the NHS Health Checks programme: baseline assessment of risk factor recording in an urban culturally diverse setting
    Andrew R H Dalton
    Department of Primary Care and Public Health, Imperial College Faculty of Medicine, St Dunstan s Road, London, UK
    Fam Pract 28:34-40. 2011
    ..The potential workload implications of the programme for general practice are considerable, particularly in deprived culturally diverse settings...
  21. pmc Achievement of treatment goals for primary prevention of cardiovascular disease in clinical practice across Europe: the EURIKA study
    Jose R Banegas
    Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid IdiPAZ, Avda Arzobispo Morcillo 2, Madrid, Spain
    Eur Heart J 32:2143-52. 2011
    Most studies on the primary prevention of cardiovascular disease (CVD) have been limited to patients at high CVD risk...
  22. pmc Rosuvastatin for primary prevention in patients with European systematic coronary risk evaluation risk ≥ 5% or Framingham risk >20%: post hoc analyses of the JUPITER trial requested by European health authorities
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Albert Einstein Allee 23, Ulm, Germany
    Eur Heart J 32:75-83. 2011
    ..approved the use of rosuvastatin to reduce first major cardiovascular events among 'high' global risk primary prevention patients defined either by Framingham risk score >20% or European systematic coronary risk evaluation (..
  23. ncbi Optimizing statin treatment for primary prevention of coronary artery disease
    Rodney A Hayward
    University of Michigan and Veteran Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan, USA
    Ann Intern Med 152:69-77. 2010
    ....
  24. ncbi European guidelines on cardiovascular disease prevention in clinical practice: full text. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by represent
    Ian Graham
    Department of Cardiology, The Adelaide and Meath Hospital, Tallaght, Dublin, Ireland
    Eur J Cardiovasc Prev Rehabil 14:S1-113. 2007
  25. pmc Accrual and drop out in a primary prevention randomised controlled trial: qualitative study
    Helen C Eborall
    Department of Health Sciences, University of Leicester, UK
    Trials 12:7. 2011
    ..Limited research on these issues has been conducted on healthy individuals recruited for prevention trials in the community...
  26. ncbi Statins for the primary prevention of cardiovascular events in older adults: a review of the evidence
    Robin Ali
    Division of Geriatric Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Geriatr Pharmacother 5:52-63. 2007
    Although statins have been demonstrated to be beneficial for secondary prevention in the elderly, their use for primary prevention has not been well described.
  27. ncbi Refined analysis of the critical age ranges of childhood overweight: implications for primary prevention
    Sascha W Hoffmann
    Department of Sports Medicine, Disease Prevention and Rehabilitation, Faculty of Social Science, Media and Sport, Johannes Gutenberg University, Mainz, Germany
    Obesity (Silver Spring) 20:2151-4. 2012
    ..We therefore propose that psychosocial correlates may be related to the general life-time event around the age of entering school...
  28. ncbi Green and black tea for the primary prevention of cardiovascular disease
    Louise Hartley
    Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, UK
    Cochrane Database Syst Rev 6:CD009934. 2013
    ..There is increasing evidence that both green and black tea are beneficial for cardiovascular disease (CVD) prevention...
  29. ncbi Folic acid and primary prevention of birth defects
    Domenica Taruscio
    National Centre for Rare Diseases, Istituto Superiore di Sanita, Rome, Italy
    Biofactors 37:280-4. 2011
    ..The Italian Network for Primary Prevention of BDs through FA Promotion has achieved a significant improvement in FA awareness and use in the ..
  30. ncbi Barriers to cardiovascular disease risk scoring and primary prevention in Europe
    F D R Hobbs
    Primary Care Clinical Sciences, University of Birmingham, Edgbaston, Birmingham, UK
    QJM 103:727-39. 2010
    ..A thorough, easy-to-use, and standardized tool for risk estimation would allow for improvements in the primary prevention of CVD.
  31. ncbi Risk factors and primary prevention of congenital Chagas disease in a nonendemic country
    Laura Murcia
    Unidad Regional de Medicina Tropical, Servicio de Microbiologia, Hospital Universitario Virgen de la Arrixaca, Palmar Murcia, Spain
    Clin Infect Dis 56:496-502. 2013
    ....
  32. ncbi Evaluating the impact of population and high-risk strategies for the primary prevention of cardiovascular disease
    Jonathan Emberson
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London NW3 2PF, UK
    Eur Heart J 25:484-91. 2004
    To estimate the potential effectiveness of different "high-risk" and "population" approaches to the primary prevention of cardiovascular disease (CVD) in middle-aged British men, after correction for regression dilution bias.
  33. ncbi Lifestyle intervention for preventing weight gain in young adults: a systematic review and meta-analysis of RCTs
    L Hebden
    The University of Sydney, School of Molecular Bioscience, Sydney, New South Wales, Australia
    Obes Rev 13:692-710. 2012
    ..Future trials conducted over longer periods with larger samples are urgently required to develop effective programmes that will protect against weight gains in future generations...
  34. ncbi Primary prevention of skin cancer: a review of sun protection in Australia and internationally
    Warren R Stanton
    School of Health and Rehabilitation Sciences, University of Queensland, St Lucia, Queensland 4072, Australia
    Health Promot Int 19:369-78. 2004
    ....
  35. pmc Cardiovascular disease prevention with a multidrug regimen in the developing world: a cost-effectiveness analysis
    Thomas A Gaziano
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Lancet 368:679-86. 2006
    ..We therefore aimed to establish whether use of evidence-based multidrug regimens for patients at high risk for cardiovascular disease would be cost-effective in low-income and middle-income countries...
  36. ncbi Cost-effectiveness of the interventions in the primary prevention of diabetes among Asian Indians: within-trial results of the Indian Diabetes Prevention Programme (IDPP)
    Ambady Ramachandran
    India Diabetes Research Foundation and Dr A Ramachandran s Diabetes Hospitals, Egmore, Chennai 600008, India
    Diabetes Care 30:2548-52. 2007
    ..The direct medical costs and cost-effectiveness of the interventions relative to the control group are reported here...
  37. pmc Biomarkers and cardiovascular risk assessment for primary prevention: an update
    Lauren G Gilstrap
    Cardiology Division and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Clin Chem 58:72-82. 2012
    Interest in cardiovascular biomarkers in primary prevention has increased dramatically in the past decade...
  38. ncbi Cost-effectiveness analysis of interventions to prevent cardiovascular disease in Vietnam
    Duc Anh Ha
    Ministry of Health, 138A Giangvo, Hanoi, Vietnam
    Health Policy Plan 26:210-22. 2011
    ..The burden of CVD will continue to rise unless effective interventions for addressing its underlying risk factors are put in place...
  39. pmc Excess risk attributable to traditional cardiovascular risk factors in clinical practice settings across Europe - The EURIKA Study
    Eliseo Guallar
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    BMC Public Health 11:704. 2011
    Physicians involved in primary prevention are key players in CVD risk control strategies, but the expected reduction in CVD risk that would be obtained if all patients attending primary care had their risk factors controlled according to ..
  40. ncbi Cancer prevention in the Asia Pacific region
    Keun Young Yoo
    Seoul National University College of Medicine, Seoul, Korea
    Asian Pac J Cancer Prev 11:839-44. 2010
    ..Moreover, countries with professionals and researchers with advanced cancer research, education, and training also need to contribute through international cooperation...
  41. pmc Pasos Adelante: the effectiveness of a community-based chronic disease prevention program
    Lisa K Staten
    Southwest Center for Community Health Promotion, Mel and Enid Zuckerman Arizona College of Public Health, University of Arizona, Division of Health Promotion Sciences, Tucson, AZ 85719, USA
    Prev Chronic Dis 2:A18. 2005
    Implementing programs that target primary prevention of chronic diseases is critical for at-risk populations...
  42. ncbi Preventive home care of frail older people: a review of recent case management studies
    Ingalill Rahm Hallberg
    Department of Nursing Care, Lund University, Sweden
    J Clin Nurs 13:112-20. 2004
    ..Perhaps effects would be expected in all three areas and thus these should be included in evaluative studies in addition to measures for family and/or informal caregiver's strain and satisfaction...
  43. ncbi Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events
    P M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 344:1959-65. 2001
    ..We hypothesized that statins might prevent coronary events in persons with elevated C-reactive protein levels who did not have overt hyperlipidemia...
  44. ncbi Primary prevention of cardiovascular disease in nursing practice: focus on children and youth: a scientific statement from the American Heart Association Committee on Atherosclerosis, Hypertension, and Obesity in Youth of the Council on Cardiovascular Dis
    Laura L Hayman
    New York University, USA
    Circulation 116:344-57. 2007
  45. ncbi Diagnosis, prevention, and management of eclampsia
    Baha M Sibai
    Department of Obstetrics and Gynecology, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Obstet Gynecol 105:402-10. 2005
    ..Recommendations for diagnosis, prevention, management, and counseling of these women are provided based on results of recent studies and my own clinical experience...
  46. pmc Rosuvastatin for primary prevention in older persons with elevated C-reactive protein and low to average low-density lipoprotein cholesterol levels: exploratory analysis of a randomized trial
    Robert J Glynn
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann Intern Med 152:488-96, W174. 2010
    Randomized data on statins for primary prevention in older persons are limited, and the relative hazard of cardiovascular disease associated with an elevated cholesterol level weakens with advancing age.
  47. ncbi Challenges and opportunities for cardiovascular disease prevention
    Manuel Franco
    Department of Epidemiology, Atherothrombosis and Imaging, National Center for Cardiovascular Research, Madrid, Spain
    Am J Med 124:95-102. 2011
    ....
  48. ncbi Primary prevention of cardiovascular diseases with statin therapy: a meta-analysis of randomized controlled trials
    Paaladinesh Thavendiranathan
    Department of Medicine, University of Toronto, Toronto, Ontario
    Arch Intern Med 166:2307-13. 2006
    ..in secondary prevention of cardiovascular (CV) events and mortality is established, their value for primary prevention is less clear...
  49. ncbi Comparing impact and cost-effectiveness of primary prevention strategies for lipid-lowering
    Mark J Pletcher
    University of California, San Francisco, San Francisco, California 94107, USA
    Ann Intern Med 150:243-54. 2009
    ..Lipid-lowering therapy is costly but effective at reducing coronary heart disease (CHD) risk...
  50. ncbi A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women
    Paul M Ridker
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, USA
    N Engl J Med 352:1293-304. 2005
    ..Randomized trials have shown that low-dose aspirin decreases the risk of a first myocardial infarction in men, with little effect on the risk of ischemic stroke. There are few similar data in women...
  51. ncbi Real-world effectiveness of a German school-based intervention for primary prevention of anorexia nervosa in preadolescent girls
    Katharina Wick
    Institute of Psychosocial Medicine and Psychotherapy, University Hospital, Friedrich Schiller University Jena, Jena, Germany
    Prev Med 52:152-8. 2011
    ..We developed a German school-based intervention program ('PriMa') for the primary prevention of AN in preadolescent girls and assessed the effects in a sample of Thuringian girls.
  52. ncbi The ICD for primary prevention in patients with inherited cardiac diseases: indications, use, and outcome: a comparison with secondary prevention
    Louise R A Olde Nordkamp
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Circ Arrhythm Electrophysiol 6:91-100. 2013
    ..This study evaluates the efficacy and harm rate of ICD implantations for primary prevention compared with secondary prevention in inherited cardiac diseases.
  53. ncbi Aspirin for primary prevention of cardiovascular disease events
    Carrie W Nemerovski
    Department of Pharmacy Services, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Pharmacotherapy 32:1020-35. 2012
    ..secondary prevention of cardiovascular disease is well established, but the clinical benefit of aspirin for primary prevention of CVD is less clear...
  54. ncbi The aspirin controversy in primary prevention
    Nina C Raju
    Haematology Unit, Pathology Queensland and Internal Medicine Unit, The Prince Charles Hospital, Brisbane, Australia
    Curr Opin Cardiol 27:499-507. 2012
    Apparently conflicting meta-analysis results have led to renewed debate about the role of aspirin for the primary prevention of cardiovascular disease...
  55. ncbi Relationship of lipoprotein-associated phospholipase A₂ mass and activity with incident vascular events among primary prevention patients allocated to placebo or to statin therapy: an analysis from the JUPITER trial
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, MA 02215, USA
    Clin Chem 58:877-86. 2012
    ..Whether measures of Lp-PLA(2) mass or activity continue to predict risk after LDL-C reduction by statin therapy is uncertain...
  56. ncbi Blockade of the renin-angiotensin-aldosterone system (RAAS) for primary prevention of non-valvular atrial fibrillation: a systematic review and meta analysis of randomized controlled trials
    Rasha Khatib
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada
    Int J Cardiol 165:17-24. 2013
    ..This review aims to assess the effectiveness of blockade of the renin-angiotensin-aldosterone system in the prevention of new onset atrial fibrillation...
  57. pmc The reduction of disability in community-dwelling frail older people: design of a two-arm cluster randomized controlled trial
    Silke F Metzelthin
    Department of Health Care and Nursing Science, School for Public Health and Primary Care CAPHRI, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
    BMC Public Health 10:511. 2010
    ....
  58. pmc Comparative effectiveness of antihypertensive medication for primary prevention of cardiovascular disease: systematic review and multiple treatments meta-analysis
    Atle Fretheim
    Global Health Unit, Norwegian Knowledge Centre for the Health Services, Oslo, Norway
    BMC Med 10:33. 2012
    ..to answer the following research question: What are the relative effects of different classes of antihypertensive drugs in reducing the incidence of cardiovascular disease outcomes for healthy people at risk of cardiovascular disease?..
  59. ncbi 'Mediterranean' dietary pattern for the primary prevention of cardiovascular disease
    Karen Rees
    Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, UK, CV4 7AL
    Cochrane Database Syst Rev 8:CD009825. 2013
    ..Later observational studies have confirmed the benefits of adherence to a Mediterranean dietary pattern on CVD risk factors. Clinical trial evidence is limited, and is mostly in secondary prevention...
  60. ncbi Primary prevention: exposure reduction, skin exposure and respiratory protection
    Dick Heederik
    Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, University of Utrecht, The Netherlands
    Eur Respir Rev 21:112-24. 2012
    Interventions for the primary prevention of occupational asthma have been reported in the medical literature, understanding the effectiveness of these efforts could help future interventions...
  61. ncbi The Drakensberg declaration on the control of rheumatic fever and rheumatic heart disease in Africa
    Bongani Mayosi
    University of Cape Town, South Africa
    S Afr Med J 96:246. 2006
  62. ncbi Primary prevention of cardiovascular disease: cost-effectiveness comparison
    Oscar H Franco
    Department of Public Health, University Medical Center Rotterdam, 50 Dr Molewaterplein, 3000 CA Rotterdam, Zuid Holland
    Int J Technol Assess Health Care 23:71-9. 2007
    The aim of this study was to evaluate the cost-effectiveness of four risk-lowering interventions (smoking cessation, antihypertensives, aspirin, and statins) in primary prevention of cardiovascular disease.
  63. ncbi [Periconceptional supplementation with folic acid for the primary prevention of congenital malformations]
    L Ronfani
    Centro per la Salute del Bambino, Trieste
    Pediatr Med Chir 26:105-11. 2004
    ..containing folic acid, beginning one month before conception and continuing through the first trimester for primary prevention of neural tube defects and other congenital malformations...
  64. ncbi Low-dose aspirin for primary prevention of cardiovascular events in patients with diabetes: a meta-analysis
    Stavros Stavrakis
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
    Am J Med Sci 341:1-9. 2011
    The use of low-dose aspirin for primary prevention of cardiovascular events in patients with diabetes is recommended by existing guidelines, but definitive evidence supporting its efficacy is lacking...
  65. ncbi Meta-analysis of multiple primary prevention trials of cardiovascular events using aspirin
    Alfred A Bartolucci
    Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Cardiol 107:1796-801. 2011
    Several meta-analyses have focused on determination of the effectiveness of aspirin (acetylsalicylic acid) in primary prevention of cardiovascular (CV) events...
  66. ncbi How willing are the public to pay for anti-hypertensive drugs for primary prevention of cardiovascular disease: a survey in a Chinese city
    Jin Ling Tang
    Chinese Cochrane Centre Hong Kong Branch, The Chinese University of Hong Kong, Hong Kong SAR, China
    Int J Epidemiol 39:244-54. 2010
    Current recommendations on drug treatment of hypertension for primary prevention of cardiovascular disease are primarily determined by the evidence of effectiveness, disregard the resources available and values of people, and recommend a ..
  67. ncbi Difference in celiac disease risk between Swedish birth cohorts suggests an opportunity for primary prevention
    Cecilia Olsson
    Department of Food and Nutrition, Umea University, SE 901 87 Umea, Sweden
    Pediatrics 122:528-34. 2008
    ..The main aim of this study was to analyze celiac disease risk in epidemic and postepidemic birth cohorts up to preschool age, to explore further the opportunity for primary prevention.
  68. ncbi Atrial fibrillation in the 21st century: a current understanding of risk factors and primary prevention strategies
    Arthur R Menezes
    Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School, The University of Queensland School of Medicine, New Orleans, LA 70121 2483, USA
    Mayo Clin Proc 88:394-409. 2013
    ..factors for AF and explore newer risk factors currently being investigated that may have implications in the primary prevention of AF...
  69. pmc Environmental and occupational interventions for primary prevention of cancer: a cross-sectorial policy framework
    Carolina Espina
    Department of Public Health and Environment, World Health Organization WHO, Geneva, Switzerland
    Environ Health Perspect 121:420-6. 2013
    ..6 million cancer deaths occur worldwide each year; 63% of cancer deaths occur in low- and middle-income countries. A substantial proportion of all cancers are attributable to carcinogenic exposures in the environment and the workplace...
  70. ncbi Gender differences in clinical outcome and primary prevention defibrillator benefit in patients with severe left ventricular dysfunction: a systematic review and meta-analysis
    Pasquale Santangeli
    Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
    Heart Rhythm 7:876-82. 2010
    Women are underrepresented in primary prevention implantable cardioverter-defibrillator (ICD) trials, and data on the benefit of ICD therapy in this subgroup are controversial.
  71. ncbi Statins in the primary prevention of cardiovascular disease
    Zeljko Reiner
    Department of Internal Medicine, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia
    Nat Rev Cardiol 10:453-64. 2013
    ..The use of these drugs for secondary prevention of CVD is well founded, but their expanding use in primary prevention--in individuals without documented CVD--has raised some concerns...
  72. ncbi Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report
    Luigi Ferrucci
    Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    J Am Geriatr Soc 52:625-34. 2004
    ....
  73. ncbi Relation of baseline high-sensitivity C-reactive protein level to cardiovascular outcomes with rosuvastatin in the Justification for Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER)
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Boston, Massachusetts, USA
    Am J Cardiol 106:204-9. 2010
    ..Trial Evaluating Rosuvastatin (JUPITER), random allocation of rosuvastatin compared to placebo among primary prevention patients with a low-density lipoprotein cholesterol level of <130 mg/dl and a high-sensitivity C-reactive ..
  74. pmc National screening program for transitional ages in Korea: a new screening for strengthening primary prevention and follow-up care
    Hyun Su Kim
    Department of Family Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 27:S70-5. 2012
    ..Lastly, we suggest several points that need to be considered to improve the program such as enhancement of participation rates, necessity of specialized committee and research for current screening program to be supported by evidence...
  75. ncbi Contemporary epidemiology of renal cell carcinoma: perspectives of primary prevention
    Steffen Weikert
    Department of Urology, Charite University Medicine Berlin, 10117 Berlin, Germany
    World J Urol 28:247-52. 2010
    ..In this review, we give an overview of recent trends in incidence and mortality and summarize the current knowledge on risk factors of RCC...
  76. ncbi Incidence and predictors of implantable cardioverter-defibrillator therapy in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy undergoing implantable cardioverter-defibrillator implantation for primary prevention
    Aditya Bhonsale
    Division of Cardiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Am Coll Cardiol 58:1485-96. 2011
    ..study was to define the incidence and predictors of implantable cardioverter-defibrillator (ICD) therapy in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) after placement of an ICD for primary prevention.
  77. ncbi Aspirin for prevention of cardiovascular events in a general population screened for a low ankle brachial index: a randomized controlled trial
    F Gerald R Fowkes
    Centre for Population Health Sciences, University of Edinburgh, Scotland
    JAMA 303:841-8. 2010
    ..Screening for a low ABI can identify an asymptomatic higher risk group potentially amenable to preventive treatments...
  78. pmc Identifying individuals for primary cardiovascular disease prevention in UK general practice: priorities and resource implications
    Tim A Holt
    Health Services Research Institute, Warwick Medical School, Coventry
    Br J Gen Pract 58:495-8. 2008
    ..2% of patients aged over 50 years with established cardiovascular disease had at least one modifiable risk factor outside the audit target of the Quality and Outcomes Framework. Implications for resource allocation are discussed...
  79. ncbi A health economic evaluation of aspirin in the primary prevention of cardiovascular disease in Japan
    Kiichiro Tsutani
    The Department of Pharmacoeconomics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    Intern Med 46:157-62. 2007
    ..But, the use of low-dose aspirin in primary prevention has not yet been fully established in Japan although meta-analyses and US/European guidelines support its ..
  80. ncbi The BioImage Study: novel approaches to risk assessment in the primary prevention of atherosclerotic cardiovascular disease--study design and objectives
    Pieter Muntendam
    BG Medicine Inc, Waltham, MA, USA
    Am Heart J 160:49-57.e1. 2010
    ..The BioImage Study will help identify those patients with subclinical atherosclerosis who are at risk for near-term atherothrombotic events and enable a more personalized management of care...
  81. ncbi A polypill for all? Critical review of the polypill literature for primary prevention of cardiovascular disease and stroke
    Katherine M Carey
    Massachusetts College of Pharmacy and Health Sciences, Worcester, MA, USA
    Ann Pharmacother 46:688-95. 2012
    ..the efficacy and safety of the polypill for prevention of cardiovascular disease (CVD) and stroke and to present literature related to the polypill components (statin, aspirin, antihypertensive) for primary prevention of CVD and stroke.
  82. ncbi Role of drugs and devices in patients at risk of sudden cardiac death
    Giuseppe Boriani
    Institute of Cardiology, University of Bologna, Azienda Ospedaliera S Orsola Malpighi, Bologna, Italy Department of Pharmacology, University of Bologna, Bologna, Italy
    Fundam Clin Pharmacol 24:575-94. 2010
    ..or a malignant ventricular tachyarrhythmias (secondary prevention of SCD) and the much broader setting of primary prevention in patients at variable degrees of identifiable risk...
  83. ncbi The role of atherosclerosis imaging in redefining normal and abnormal cholesterol values, and risk reduction in primary prevention statin trials
    Harvey S Hecht
    Lenox Hill Heart and Vascular Institute, 130 E 77th St, New York, NY 10021, USA
    Curr Atheroscler Rep 13:422-30. 2011
    ..of cardiovascular events than risk factors of atherosclerosis, has created a paradigm shift in the primary prevention of cardiovascular disease...
  84. ncbi Changing the odds. What do we learn from prevention studies targeted at people with a positive family history of type 2 diabetes?
    Wieke H Heideman
    Department of Medical Psychology, The EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands
    Prim Care Diabetes 5:215-21. 2011
    ..They can and should be approached with the aim to raise risk awareness and promote healthy eating, weight loss and physical activity, thereby reducing their risk of developing diabetes...
  85. ncbi Predictors of adherence to statins for primary prevention
    Devin M Mann
    Division of General Internal Medicine, Mount Sinai School of Medicine, 1470 Madison Ave, Box 1087, New York, NY 10029, USA
    Cardiovasc Drugs Ther 21:311-6. 2007
    ..This prospective study was designed to identify potentially modifiable patient factors including medication, disease, and diet beliefs related to statin adherence...
  86. ncbi Risk factors and primary prevention of acute leukemia
    Gul Ilhan
    Department of Hematology, Baskent University Medical School, Ankara, Turkey
    Asian Pac J Cancer Prev 7:515-7. 2006
    ..To explain the etiology of all leukemias and develop preventive methods for the disease, future studies are needed...
  87. ncbi Carotid intima-media thickness as a screening tool in cardiovascular primary prevention
    Antonio L Aguilar-Shea
    Family Practice, Centro de Salud Espronceda, Área 7 de Madrid, Spain
    Eur J Clin Invest 41:521-6. 2011
    ..Increased carotid intima-media thickness (CIMT) is associated with cardiovascular events. The purpose of this study was to identify advanced subclinical atherosclerosis in patients who are at low or intermediate risk...
  88. ncbi Primary prevention of stroke: blood pressure, lipids, and heart failure
    Matthias Endres
    Klinik und Hochschulambulanz für Neurologie, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur Heart J 32:545-52. 2011
    ..of stroke, the global burden of this disease can only be tackled with co-ordinated approaches for primary prevention. Stroke is a heterogeneous disease and the contribution of individual risk factors to its occurrence ..
  89. ncbi Aspirin for primary prevention: yes or no?
    Vanessa Selak
    Clinical Trials Research Unit, School of Population Health, The University of Auckland, Auckland, New Zealand
    J Prim Health Care 2:92-9. 2010
    To assess benefit versus harm of aspirin for cardiovascular disease (CVD) primary prevention by age group, gender and risk category and to interpret these results in light of current New Zealand CVD risk assessment and management ..
  90. pmc Communicating evidence-based information on cancer prevention to state-level policy makers
    Ross C Brownson
    Alvin J Siteman Cancer Center, Washington University School of Medicine, Washington University, St Louis, MO 63110, USA
    J Natl Cancer Inst 103:306-16. 2011
    ..We explored factors that influence the likelihood that state-level policy makers will find a policy brief understandable, credible, and useful...
  91. ncbi Long-term follow-up of primary and secondary prevention implantable cardioverter defibrillator patients
    Guido H van Welsenes
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Europace 13:389-94. 2011
    ..The aim of the study was to assess differences in mortality and ICD therapy between secondary and primary prevention ICD recipients.
  92. pmc Bridging the gap between public health and primary care in prevention of cardiometabolic diseases; background of and experiences with the Prevention Consultation in The Netherlands
    Willem J J Assendelft
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    Fam Pract 29:i126-i131. 2012
    ..This initiative was supported by the national professional organizations of GPs and occupational physicians as well as three large health foundations...
  93. pmc Rationale and methods of the European Study on Cardiovascular Risk Prevention and Management in Daily Practice (EURIKA)
    Fernando Rodriguez-Artalejo
    Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autonoma de Madrid, CIBER of Epidemiology and Public Health, Madrid 28029, Spain
    BMC Public Health 10:382. 2010
    The EURIKA study aims to assess the status of primary prevention of cardiovascular disease (CVD) across Europe...
  94. pmc The NOURISH randomised control trial: positive feeding practices and food preferences in early childhood - a primary prevention program for childhood obesity
    Lynne A Daniels
    School of Public Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
    BMC Public Health 9:387. 2009
    b>Primary prevention of childhood overweight is an international priority. In Australia 20-25% of 2-8 year olds are already overweight...
  95. pmc Potential use of 10-year and lifetime coronary risk information for preventive cardiology prescribing decisions: a primary care physician survey
    Stephen D Persell
    Northwestern University, Chicago, IL 60611, USA
    Arch Intern Med 170:470-7. 2010
    ..Data are sparse regarding how physicians use coronary risk information for prescribing decisions...
  96. ncbi Rosuvastatin for primary prevention among individuals with elevated high-sensitivity c-reactive protein and 5% to 10% and 10% to 20% 10-year risk. Implications of the Justification for Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvas
    Paul M Ridker
    Center for Cardiovascular Disease Prevention and Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circ Cardiovasc Qual Outcomes 3:447-52. 2010
    Recent primary prevention guidelines issued in Canada endorse the use of statin therapy among individuals at "intermediate risk" who have elevated levels of high-sensitivity C-reactive protein (hsCRP)...
  97. ncbi Influence of general self-efficacy on the effects of a school-based universal primary prevention program of depressive symptoms in adolescents: a randomized and controlled follow-up study
    Patrick Pössel
    University of Tuebingen at Tuebingen, Germany
    J Child Psychol Psychiatry 46:982-94. 2005
    ..Depressive disorders in adolescents are a widespread and increasing problem. Prevention seems a promising and feasible approach...
  98. pmc Recent advances in the management of chronic stable angina II. Anti-ischemic therapy, options for refractory angina, risk factor reduction, and revascularization
    Richard Kones
    Cardiometabolic Research Institute, Houston, Texas 77055, USA
    Vasc Health Risk Manag 6:749-74. 2010
    ..Optimal medical therapy, percutaneous coronary intervention, and surgery are not competing therapies, but are complementary and form a continuum, each filling an important evidence-based need in modern comprehensive management...
  99. ncbi Applicability of cholesterol-lowering primary prevention trials to a general population: the framingham heart study
    D M Lloyd-Jones
    Framingham Heart Study, 5 Thurber St, Framingham, MA 01702, USA
    Arch Intern Med 161:949-54. 2001
    Four large trials have shown cholesterol-reduction therapy to be effective for primary prevention of coronary heart disease (CHD).
  100. ncbi Primary prevention in rheumatology: the importance of hyperuricemia
    Janitzia Vazquez-Mellado
    Rheumatology Service, Hospital General de Mexico, Faculty of Medicine, Universidad Nacional Autonoma de Mexico, Dr Balmis 148, Col Doctores, 06726 Mexico City, Mexico
    Best Pract Res Clin Rheumatol 18:111-24. 2004
    ..Patients with chronic HU and also those with gout require both medical investigation for associated diseases or drugs as well as nutritional counseling and life-style changes. HU should alert physicians to possible complications...
  101. ncbi Combined effect of low-risk dietary and lifestyle behaviors in primary prevention of myocardial infarction in women
    Agneta Akesson
    Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, 17177 Stockholm, Sweden
    Arch Intern Med 167:2122-7. 2007
    ..Limited data are available on the benefit of combining healthy dietary and lifestyle behaviors in the prevention of myocardial infarction (MI) in women...

Research Grants73

  1. Triggers of Abruptio Placentae - A Case Crossover Study of an Ischemic Placental
    Michelle A Williams; Fiscal Year: 2013
    ..Collectively, these new insights may facilitate the development of new approaches for the primary prevention of AP (at the public health level) and may also facilitate the development of new therapies and methods for ..
  2. Molecular Epidemiology of DNA Repair in Head and Neck Cancer
    Qingyi Wei; Fiscal Year: 2012
    ..effective biomarkers for risk assessment and to identify at-risk individuals who can be targeted for primary prevention and early detection of SCCHN in the general population...
  3. Lung VITamin D and OmegA-3 TriaL (Lung VITAL)
    Diane R Gold; Fiscal Year: 2013
    ..of a large-scale randomized clinical trial-the VITamin D and OmegA-3 TriaL (VITAL), whose endpoints are primary prevention of cancer and cardiovascular diseases-to conduct the first major evaluation of the role of vitamin D and ..
  4. Validation of a functional MRI-based reward processing task as a non-invasive too
    MARY LOUISE PHILLIPS; Fiscal Year: 2010
    ..identification of those most at risk of the development of disorder which will allow appropriately targeted primary prevention and finally, the development of pathophysiologically based treatments...
  5. Chemoprevention of urinary bladder carcinogenesis by flavokawain A
    Xiaolin Zi; Fiscal Year: 2012
    ..The OH-BBN model in mice will be used to examine flavokawain A's utility in primary prevention;for preventing the first occurrence of bladder cancer in those with risk factors such as cigarette smoking ..
  6. Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Joint Pain
    Karen H Costenbader; Fiscal Year: 2013
    ..However, large primary prevention trials with adequate dosing in general populations (i.e...
  7. Vitamin D and Vascular Function in Obese Children
    Kumaravel Rajakumar; Fiscal Year: 2013
    ..D would have major public health importance, since optimization of vitamin D status would be an inexpensive primary prevention strategy for improving cardiometabolic health during childhood and for reducing CVD risk during adulthood.
  8. Biomarkers of Sudden Death and Progressive Heart Failure
    GORDON FRANK TOMASELLI; Fiscal Year: 2010
    ..with ischemic and non-ischemic cardiomyopathy (ejection fraction <35%) undergoing ICD implantation for primary prevention of SCD...
  9. Effects of Vitamin D and Marine Omega-3 Fatty Acids on Anemia in the Elderly
    Nancy Berliner; Fiscal Year: 2013
    ..trial analyzing the role of vitamin D3 and marine omega-3 fatty acid (?-3 FA) supplements in the primary prevention of cancer and cardiovascular disease among 20,000 US men and women aged >60 and >65 years, ..
  10. Creation of Eating/Activity Environments by New Mothers
    Deborah Young Hyman; Fiscal Year: 2010
    ..Results will be used to develop a family based Primary Prevention intervention to prevent Overweight Development in very young children...
  11. Pregnancy Folate Status &Early Childhood Respiratory &Atopic Disease Outcomes
    KECIA NICOLE CARROLL; Fiscal Year: 2013
    ..Opportunity and Impact. There is no primary prevention strategy for atopic diseases such as asthma...
  12. Identifying Biomarkers for Post-Partum Depression in African-American Women
    Patrick F Sullivan; Fiscal Year: 2013
    ..Future research could evaluate whether a biomarker signature is of predictive utility and, if so, rational primary prevention may become feasible.
  13. Integrated Cardio-Renal Risk Prediction Models in Type 1 Diabetes
    Marian J Rewers; Fiscal Year: 2010
    ..b>Primary prevention with ACE/ARB treatment usually begins when persistent microalbuminuria is found...
  14. Vitamin D and Omega-3 Fatty Acids(VITAL Trial): Effects on Fractures
    MERYL SUSAN LEBOFF; Fiscal Year: 2013
    ..Large primary prevention trials with high daily doses of vitamin D and/or omega-3 fatty acids in general populations (i.e...
  15. Role of Genetic Susceptibility in Therapy-related Subsequent Malignancies
    Smita Bhatia; Fiscal Year: 2013
    ..and facilitate identification of cancer survivors at high-risk for development of SMNs, in turn facilitating primary prevention (individualizing therapy in future cancer populations) and secondary prevention (targeted screening, ..
  16. Low energy ventricular defibrillator
    Qun Sha; Fiscal Year: 2012
    ..In the primary prevention era, inappropriate shocks are even more troublesome, since appropriate shocks are decreasing in incidence;..
  17. Utility of Phosphatidylethanol for Identification of Fetal Alcohol Exposure
    LUDMILA NICOLE BAKHIREVA; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Primary prevention of Fetal Alcohol Spectrum Disorders (FASD) is often problematic due to difficulties of early identification of alcohol use among pregnant women or women who might become pregnant...
  18. Preventing Anthracycline Cardiovascular Toxicity with Statins
    William Gregory Hundley; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This application addresses a neglected major problem: no effective primary prevention for anthracycline- based chemotherapeutic (Anth-bC) myocardial injury experienced during and after treatment for ..
  19. A Large Randomized Trial of Vitamin D, Omega-3 Fatty Acids and Cognitive Decline
    Jae H Kang; Fiscal Year: 2013
    ..January 2010) to investigate the effects of vitamin D and marine omega-3 fatty acid supplements on the primary prevention of cardiovascular disease and cancer...
  20. Genotypes and Phenotypes of Apoptosis and Risk of Head and Neck Cancer
    Qingyi Wei; Fiscal Year: 2013
    ..effective biomarkers for risk assessment and to identify at-risk individuals who can be targeted for primary prevention and early detection of SCCHN in the general population...
  21. SINGLE SUTURE CRANIOSYNOSTOSIS: CANDIDATE GENE AND PATHWAY DISCOVERY
    Michael L Cunningham; Fiscal Year: 2013
    ..There is an incomplete understanding of the causes of craniosynostosis and we lack experimental models. The development of these resources will improve clinical care, design biologically based therapies, and pursue primary prevention.
  22. Cumulative Stress and CVD Risk in Middle-Aged and Older Women
    Michelle A Albert; Fiscal Year: 2013
    ..The WHS was initiated in 1992 as a randomized trial of aspirin and vitamin E in the primary prevention of cancer and cardiovascular disease among 39, 876 female health professionals aged 45 years or older...
  23. The Aging Kidney in HIV-Infection: biomarkers for early detection of injury
    Michael G Shlipak; Fiscal Year: 2013
    ..filtration rate (GFR) has been substantially reduced;by this time, kidney disease is established and the primary prevention window has closed...
  24. VITAL-DEP: Depression Endpoint Prevention in the VITamin D and OmegA-3 TriaL
    OLIVIA IFEOMA OKEREKE; Fiscal Year: 2013
    ..RCT designed to evaluate the efficacy of vitamin D3 and marine omega-3 fatty acid supplements in the primary prevention of cardiovascular disease and cancer among 20,000 older U.S. men and women. We will address two primary aims...
  25. The impact of genetic testing for type 2 diabetes on health behaviors
    William S Yancy; Fiscal Year: 2013
    ..New approaches to primary prevention could incorporate tests for genetic and genomic risk of T2DM, creating a sizable and growing opportunity for ..
  26. Eleventh Annual AACR International Conference on Frontiers in Cancer Prevention R
    MARGARET FOTI; Fiscal Year: 2012
    ..Several steps within carcinogenic initiation and progression are targets for cancer prevention. Primary prevention is the avoidance of exposure to carcinogens or the carcinogenic process and may be directed at the broad ..
  27. Strengthening Supports for Healthy Relationships: A Gender-Sensitive, Mixed Metho
    Poco Kernsmith; Fiscal Year: 2013
    ..place in a collaborative effort between the research team and schools in order to build infrastructure for primary prevention. In order to test the proposed hypotheses, analysis will be conducted using hierarchical linear modeling and ..
  28. The Comparative Effectiveness of Single versus Dual Chamber Cardioverter Defibril
    Pamela N Peterson; Fiscal Year: 2013
    ..of landmark clinical efficacy trials, the use of implantable cardioverter defibrillators (ICDs) for the primary prevention of sudden cardiac death in patients with HF and reduced left ventricular function has increased...
  29. History of Alzheimer predisposes children to amyloid beta-related hypometabolism
    Lisa Mosconi; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Primary prevention trials for Alzheimer's disease will require accurate identification of normal individuals at increased ..
  30. Longitudinal Study of Dental Caries in VLBW Infants
    Suchitra S Nelson; Fiscal Year: 2013
    ..The clinical implications include primary prevention, early diagnosis and treatment to prevent further susceptibility to dental decay...
  31. Red Blood Cell Omega-3 Fatty Acids and Coronary Artery Disease
    Luc Djousse; Fiscal Year: 2010
    ..of n-3 FA on CAD and will provide pilot data to support a future application seeking funding for a larger primary prevention trial to investigate beneficial effects of n-3 enriched foods on CAD...
  32. VITamin D and omegA-3 triaL (VITAL)
    JOANN ELISABETH MANSON; Fiscal Year: 2013
    ..and marine omega-3 fatty acid (eicosapentaenoic acid [EPA] + docosahexaenoic acid [DHA]) supplements in the primary prevention of cancer and cardiovascular disease (CVD)...
  33. Head and Neck Cancer Risk Prediction Model
    Yuan Chin Amy Lee; Fiscal Year: 2013
    ..who have family history of HNC), and 4) for research use to select high risk populations for studies of primary prevention. Additionally, the prediction model can serve as a tool to estimate risk reduction for individuals to ..
  34. Environment, Psychosocial Stress and Self-regulatory Development
    SARA BURR JOHNSON; Fiscal Year: 2013
    ..is central to the candidate's long-term goal, which is to improve population health by identifying primary prevention strategies for negative health outcomes related to self-regulation, including mental health and substance ..
  35. SOCIODEMOGRAPHIC REGULATION OF CV FUNCTION AND STRUCTURE
    Frank A Treiber; Fiscal Year: 2010
    ..It will also aid the development of more personalized primary prevention programs involving lifestyle interventions in which the role of chronic stress will be taken into account to ..
  36. Genetic Epidemiology of Treatment Resistant Hypertension in African Americans
    CHRISTOPHER O apos BRIAN PHILLIPS; Fiscal Year: 2013
    ..application of genetic epidemiology, translational research methods and health services research to improve primary prevention, risk stratification and management of cardiovascular disease among racial and ethnic minorities. Dr...
  37. Fundamental Biology of SCD and its Application to Identify Patients at Risk
    GORDON FRANK TOMASELLI; Fiscal Year: 2013
    ..with structural heart disease and reduced left ventricular ejection fraction undergo ICD implantation for primary prevention of SCD...
  38. A Randomized Efficacy Trial of Moms and Teens for Safe Dates
    Vangie A Foshee; Fiscal Year: 2012
    ..Objectives: The proposed study is to test the efficacy of a selective family-based program for the primary prevention of dating abuse perpetration targeted at adolescents who have been exposed to domestic violence...
  39. PRIMARY HIV PREVENTION IN PREGNANT AND LACTATING UGANDAN WOMEN:A RANDOMIZED TRIAL
    Jaco Homsy; Fiscal Year: 2013
    ..Enhanced counseling will emphasize the concept of an HIV-free and healthy baby and family based on primary prevention, adequate infant feeding and family planning...
  40. Diabetes Prevention in the Vitamin D and Omega-3 Trial
    Yiqing Song; Fiscal Year: 2013
    ..specifically designed to evaluate the efficacy of vitamin D and marine omega-3 fatty acid supplements in the primary prevention of cancer and cardiovascular disease (CVD) among 20,000 U.S. men and women...
  41. Epidemiology, genetics, and behaviors in a study of basal cell carcinoma
    LEAH MCARTHUR FERRUCCI; Fiscal Year: 2012
    ..so identifying new risk factors in an epidemiologic study can have a significant, but low-cost impact on primary prevention. Although BCC is treatable, individuals incur significant healthcare costs and decreased quality of life...
  42. Are Cardioprotective Medications Effective in ESRD?
    Theresa I Shireman; Fiscal Year: 2011
    ..Our primary prevention cohort is expected to include over 40,000 individuals without ischemic heart disease upon dialysis ..
  43. Physical Activity and Diet in the Prevention of Obesity in Men and Women
    Howard D Sesso; Fiscal Year: 2010
    ..provided by applicant): The growing obesity epidemic in the US has heightened the importance of its primary prevention across all ages;however, prevention efforts generally focus upon community-based intervention studies in ..
  44. Cancer Health Disparities Training Program
    Eugenia Eng; Fiscal Year: 2013
    ..and understand cross-cutting health disparity issues in cancer across the cancer continuum from etiology and primary prevention to survivorship...
  45. HIV Prevention for Batswana Youth: Adaptation of an Evidence-Based Intervention
    Janet S St Lawrence; Fiscal Year: 2013
    ..this emphasis on biomedical strategies for case finding, care, and treatment has not been paralleled by primary prevention programs...
  46. ASPirin in Reducing Events in the Elderly
    JOHN JAMES MCNEIL; Fiscal Year: 2013
    This Application seeks funding for a randomized double-blind placebo-controlled trial of aspirin in primary prevention in healthy elderly people aged 70 years and over...
  47. Physician Attitudes toward New Biomedical HIV Prevention Interventions in Youth
    Tanya L Kowalczyk Mullins; Fiscal Year: 2013
    ..Although new biomedical primary prevention agents such as microbicides and pre-exposure prophylaxis (PrEP) decrease rates of HIV acquisition in trials, ..
  48. Urinary Biomarkers in Biopsy Defined Early Nephropathy in Types 1 and 2 Diabetes
    S MICHAEL MAUER; Fiscal Year: 2013
    ..at risk could allow for patient selection for more aggressive diabetes intervention and better design of primary prevention studies...
  49. ENERGY BALANCE AND RISK OF BPH-RELATED OUTCOMES AND LUTS: A PROSPECTIVE STUDY
    Siobhan Sutcliffe; Fiscal Year: 2012
    ..modifiable risk factors for BPH/LUTS development and their timing of action is crucial to inform effective primary prevention strategies...
  50. Tenth Annual AACR International Conference on Frontiers in Cancer Prevention Rese
    MARGARET FOTI; Fiscal Year: 2011
    ..Several steps within carcinogenic initiation and progression are targets for cancer prevention. Primary prevention is the avoidance of exposure to carcinogens or the carcinogenic process and may be directed at the broad ..
  51. VITAL-AMD: Prevention of AMD in the VITamin D and OmegA-3 Trial
    Debra A Schaumberg; Fiscal Year: 2013
    ..omega-3 fatty acid (eicosapentaenoic acid [EPA] + docosahexaenoic acid [DHA], 1 g/d) supplements in the primary prevention of cancer and cardiovascular disease...
  52. Science and Community: Partnering to prevent early childhood obesity
    Rebecca E Lee; Fiscal Year: 2013
    ..as the age of five, making early childhood a most vulnerable time in the lifespan and a key opportunity for primary prevention. Diets of preschool aged children lack fruit and vegetables, and children in preschool do little physical ..
  53. A Primary Prevention Trial to Strengthen Child Attachment in a Native Community
    Dedra S Buchwald; Fiscal Year: 2013
    ..the Promoting First Relationships (PFR) program, a theoretically driven, relationship- and strengths-based primary prevention program...
  54. Vaccinology in the Tropics: Vaccines in a Globalized World Conference
    ARLENE ESTELLA CALVO; Fiscal Year: 2012
    ..b>Primary prevention in the form of vaccination policy, services, implementation, and evaluation is one of the major components ..
  55. International Population Study on Macronutrients and BP - INTERMAP
    LINDA VERNER VAN HORN; Fiscal Year: 2013
    ..e., to enhance dietary recommendations for primary prevention/ control of prehypertension/hypertension with consequence sizable reduction in cardiovascular disease risks...
  56. Neuroimaging and Genetic Study of Inhibited Temperament
    Jennifer Urbano Blackford; Fiscal Year: 2012
    ..risk for SAD will provide new information for developing methods for identification, novel interventions, and primary prevention strategies for psychiatric disease in children and adolescents with these temperamental vulnerabilities.
  57. Screening and Risk Biomarkers for Ovarian Cancer in EPIC Specimens
    DANIEL WILLIAM CRAMER; Fiscal Year: 2013
    ..In turn, primary prevention requires better biomarkers of risk, especially those which might translate into strategies for intervention;..
  58. Clinical & Cost Effectiveness of HPV Vaccination in the US
    Sue Goldie; Fiscal Year: 2009
    ..Cervical Cancer Screening Model to be capable of assessing the costs, benefits, and cost-effectiveness of primary prevention (vaccination), secondary prevention (screening), and strategies that combine both...
  59. Natural History of Pre-diabetic Autoimmunity (DAISY)
    Marian J Rewers; Fiscal Year: 2013
    ..studies are important to reach our overarching goals: to find the environmental causes of T1D, develop primary prevention, and inform public health screening for several autoimmune disorders in children and adolescents...
  60. The Nashville Breast Health Study
    Wei Zheng; Fiscal Year: 2009
    ..regarding their associations with breast cancer risk could have important public health implications in the primary prevention of breast cancer...
  61. Staying Off Substances: A Tailored Early Recovery Program for Teens
    KIMBERLEE JEAN TRUDEAU; Fiscal Year: 2012
    ..Whereas current online programs for adolescents are geared for primary prevention, CHAT(R): SOS will be an intervention for use in clinical populations...
  62. Peripheral TGF-beta Pathway Inhibitor Therapy in Alzheimer's Rats
    Terrence Town; Fiscal Year: 2013
    ..However, broadly inhibiting inflammation has not produced a positive signal for AD primary prevention. This and other evidence has prompted our overarching hypothesis: that re-balancing inflammation as opposed ..
  63. Venous thromboembolism among California cancer patients
    Helen Chew; Fiscal Year: 2003
    ..that use of anticoagulants, such as warfarin or low molecular weight heparin, may be beneficial in the primary prevention of VTE among cancer patients...
  64. Decision-Making about Childhood HPV Vaccination among Low SES Mothers
    TIFFANY FLOYD; Fiscal Year: 2009
    ..an unprecedented opportunity to eliminate disparities in cervical cancer morbidity and mortality through the primary prevention of the disease...
  65. Primary Prevention of Hypertension in Obese Adolescents
    Daniel Feig; Fiscal Year: 2006
    ....
  66. Engaging Teen Bystanders to Prevent Sexual Violence: A Web-based Approach
    LINDA S BAIR; Fiscal Year: 2010
    ..Thus, there is a need for effective and innovative primary prevention programs...
  67. VITAMIN E ATHEROSCLEROSIS PREVENTION STUDY
    HOWARD HODIS; Fiscal Year: 1999
    ..Vitamin E supplementation provides a promising approach for primary prevention of CHD since it is natural, safe, highly tolerable, and inexpensive...
  68. Intimate Partner Violence Among Low-Income Pregnant Women: Multilevel Analysis
    Qing Li; Fiscal Year: 2005
    ..IPV in the transition to parenthood warrants special attention on risk assessment and primary prevention from an ecological perspective and an approach directed at the potential perpetrators...
  69. Preventing Child Residential Lead Exposure By Window Replacement
    MICHAEL LANE WEITZMAN; Fiscal Year: 2010
    ..multiple agencies and constituencies of the significant gains to housing and community health by linking the primary prevention of childhood lead exposure to activities that will be carried out by multiple private and public agencies as ..
  70. PSYCHOSOCIAL FACTORS IN SUDDEN CARDIAC DEATH
    Sue Thomas; Fiscal Year: 2002
    ..defibrillators (ICD) on the psychosocial status of heart failure (HF) patients who receive ICD as primary prevention for sudden cardiac death (SCD); and 4) compare the psychosocial impact of ICD with the impact of the other ..
  71. Primary Prevention of Weight Gain for Women Aged 25-45
    Walter Willett; Fiscal Year: 2004
    ....
  72. B VITAMIN ATHEROSCLEROSIS INTERVENTION TRAIL
    HOWARD HODIS; Fiscal Year: 2004
    DESCRIPTION (adapted from the application): Although primary prevention strategies have focused on key modifiable risk factors for development and progression of atherosclerosis, such as hypercholesterolemia, coronary heart disease (CHD) ..
  73. TRIAL OF ASPIRIN AND VITAMIN E IN WOMEN
    Julie Buring; Fiscal Year: 2000
    ..alternate days), vitamin E (600 IU on alternate days), and beta-carotene (50 mg on alternate days) ina the primary prevention of cardiovascular disease and cancer among approximately 40,000 US female health professionals, aged 45 ..