intensive care units

Summary

Summary: Hospital units providing continuous surveillance and care to acutely ill patients.

Top Publications

  1. ncbi Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    D C Angus
    Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, and the Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 29:1303-10. 2001
  2. doi Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009
    Seema Jain
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 361:1935-44. 2009
  3. ncbi Critically ill patients with 2009 influenza A(H1N1) infection in Canada
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre, JJ 399, 700 William Ave, Winnipeg, MB R3E 0Z3 Canada
    JAMA 302:1872-9. 2009
  4. ncbi International study of the prevalence and outcomes of infection in intensive care units
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    JAMA 302:2323-9. 2009
  5. ncbi Comparison of two fluid-management strategies in acute lung injury
    Herbert P Wiedemann
    Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, 9500 Euclid Ave, Desk A 90, Cleveland, OH 44195, USA
    N Engl J Med 354:2564-75. 2006
  6. ncbi An intervention to decrease catheter-related bloodstream infections in the ICU
    Peter Pronovost
    School of Medicine, Johns Hopkins University, Baltimore, USA
    N Engl J Med 355:2725-32. 2006
  7. ncbi Incidence and prognosis of intraabdominal hypertension in a mixed population of critically ill patients: a multiple-center epidemiological study
    Manu L N G Malbrain
    Intensive Care Unit Director, Medical Intensive Care Unit, Ziekenhuis Netwerk Antwerpen, Campus Stuivenberg, Lange Beeldekensstraat 267, B 2060 Antwerpen 6, Belgium
    Crit Care Med 33:315-22. 2005
  8. ncbi Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study
    Andres Esteban
    Unidad de Cuidados Intensivos, Hospital Universitario de Getafe, Carretera de Toledo Km 12, 5, 28905 Getafe, Madrid, Spain
    JAMA 287:345-55. 2002
  9. doi Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial
    Richard R Riker
    University of Vermont College of Medicine, USA
    JAMA 301:489-99. 2009
  10. pmc Correlates of severe disease in patients with 2009 pandemic influenza (H1N1) virus infection
    Ryan Zarychanski
    Department of Internal Medicine, University of Manitoba, CancerCare Manitoba, Winnipeg, Manitoba
    CMAJ 182:257-64. 2010

Detail Information

Publications287 found, 100 shown here

  1. ncbi Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    D C Angus
    Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, and the Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 29:1303-10. 2001
    ..To determine the incidence, cost, and outcome of severe sepsis in the United States...
  2. doi Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009
    Seema Jain
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 361:1935-44. 2009
    ..We describe the clinical characteristics of patients who were hospitalized with 2009 H1N1 influenza in the United States from April 2009 to mid-June 2009...
  3. ncbi Critically ill patients with 2009 influenza A(H1N1) infection in Canada
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre, JJ 399, 700 William Ave, Winnipeg, MB R3E 0Z3 Canada
    JAMA 302:1872-9. 2009
    ..Between March and July 2009, the largest number of confirmed cases of 2009 influenza A(H1N1) infection occurred in North America...
  4. ncbi International study of the prevalence and outcomes of infection in intensive care units
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    JAMA 302:2323-9. 2009
    Infection is a major cause of morbidity and mortality in intensive care units (ICUs) worldwide. However, relatively little information is available about the global epidemiology of such infections.
  5. ncbi Comparison of two fluid-management strategies in acute lung injury
    Herbert P Wiedemann
    Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, 9500 Euclid Ave, Desk A 90, Cleveland, OH 44195, USA
    N Engl J Med 354:2564-75. 2006
    ..Optimal fluid management in patients with acute lung injury is unknown. Diuresis or fluid restriction may improve lung function but could jeopardize extrapulmonary-organ perfusion...
  6. ncbi An intervention to decrease catheter-related bloodstream infections in the ICU
    Peter Pronovost
    School of Medicine, Johns Hopkins University, Baltimore, USA
    N Engl J Med 355:2725-32. 2006
    ..Catheter-related bloodstream infections occurring in the intensive care unit (ICU) are common, costly, and potentially lethal...
  7. ncbi Incidence and prognosis of intraabdominal hypertension in a mixed population of critically ill patients: a multiple-center epidemiological study
    Manu L N G Malbrain
    Intensive Care Unit Director, Medical Intensive Care Unit, Ziekenhuis Netwerk Antwerpen, Campus Stuivenberg, Lange Beeldekensstraat 267, B 2060 Antwerpen 6, Belgium
    Crit Care Med 33:315-22. 2005
    ....
  8. ncbi Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study
    Andres Esteban
    Unidad de Cuidados Intensivos, Hospital Universitario de Getafe, Carretera de Toledo Km 12, 5, 28905 Getafe, Madrid, Spain
    JAMA 287:345-55. 2002
    ..The outcome of patients receiving mechanical ventilation for particular indications has been studied, but the outcome in a large number of unselected, heterogeneous patients has not been reported...
  9. doi Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial
    Richard R Riker
    University of Vermont College of Medicine, USA
    JAMA 301:489-99. 2009
    ..Gamma-aminobutyric acid receptor agonist medications are the most commonly used sedatives for intensive care unit (ICU) patients, yet preliminary evidence indicates that the alpha(2) agonist dexmedetomidine may have distinct advantages...
  10. pmc Correlates of severe disease in patients with 2009 pandemic influenza (H1N1) virus infection
    Ryan Zarychanski
    Department of Internal Medicine, University of Manitoba, CancerCare Manitoba, Winnipeg, Manitoba
    CMAJ 182:257-64. 2010
    ..The objective of this study was to identify factors correlated with severity of disease in confirmed cases of pandemic H1N1 influenza...
  11. doi International Nosocomial Infection Control Consortium (INICC) report, data summary for 2003-2008, issued June 2009
    Victor D Rosenthal
    International Nosocomial Infection Control Consortium, Buenos Aires, Argentina
    Am J Infect Control 38:95-104.e2. 2010
    ..Infection Control Consortium (INICC) surveillance study from January 2003 through December 2008 in 173 intensive care units (ICUs) in Latin America, Asia, Africa, and Europe...
  12. ncbi Prevalence of intra-abdominal hypertension in critically ill patients: a multicentre epidemiological study
    Manu L N G Malbrain
    Medical Intensive Care Unit, ACZA Campus Stuivenberg, Lange Beeldekensstraat 267, 2060 Antwerp, Belgium manu malbrain skynet be
    Intensive Care Med 30:822-9. 2004
    ..This study assessed the prevalence of IAH and its risk factors in a mixed population of intensive care patients...
  13. ncbi Sepsis in European intensive care units: results of the SOAP study
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Med 34:344-53. 2006
    To better define the incidence of sepsis and the characteristics of critically ill patients in European intensive care units.
  14. doi Veterans Affairs initiative to prevent methicillin-resistant Staphylococcus aureus infections
    Rajiv Jain
    Patient Care Services, Veterans Affairs Central Office, and the VA Pittsburgh Healthcare System, Pittsburgh, USA
    N Engl J Med 364:1419-30. 2011
    ..Health care-associated infections with methicillin-resistant Staphylococcus aureus (MRSA) have been an increasing concern in Veterans Affairs (VA) hospitals...
  15. ncbi Continuous renal replacement therapy: a worldwide practice survey. The beginning and ending supportive therapy for the kidney (B.E.S.T. kidney) investigators
    Shigehiko Uchino
    Jikei University School of Medicine, Intensive Care Unit, Department of Anesthesiology, Tokyo, Japan
    Intensive Care Med 33:1563-70. 2007
    ..Little information is available regarding current practice in continuous renal replacement therapy (CRRT) for the treatment of acute renal failure (ARF) and the possible clinical effect of practice variation...
  16. doi Epidemiology, management, and risk factors for death of invasive Candida infections in critical care: a multicenter, prospective, observational study in France (2005-2006)
    Olivier Leroy
    Service de Réanimation Médicale et des Maladies Infectieuses, Centre Hospitalier Gustave Dron, Tourcoing, France
    Crit Care Med 37:1612-8. 2009
    To describe the evolving epidemiology, management, and risk factors for death of invasive Candida infections in intensive care units (ICUs).
  17. pmc Risk of severe outcomes among patients admitted to hospital with pandemic (H1N1) influenza
    Alexia Campbell
    Centre for Immunization and Respiratory Infectious Diseases, Infectious Disease and Emergency Preparedness Branch, Public Health Agency of Canada, Ottawa, Ontario
    CMAJ 182:349-55. 2010
    ....
  18. ncbi Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients
    M H Kollef
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Chest 115:462-74. 1999
    ..To evaluate the relationship between inadequate antimicrobial treatment of infections (both community-acquired and nosocomial infections) and hospital mortality for patients requiring ICU admission...
  19. ncbi Early versus late parenteral nutrition in critically ill adults
    Michael P Casaer
    Department of Intensive Care Medicine, University Hospitals of the Catholic University of Leuven, Leuven, Belgium
    N Engl J Med 365:506-17. 2011
    ..Controversy exists about the timing of the initiation of parenteral nutrition in critically ill adults in whom caloric targets cannot be met by enteral nutrition alone...
  20. ncbi Patients readmitted to ICUs* : a systematic review of risk factors and outcomes
    A L Rosenberg
    Department of Anesthesiology and Critical Care, University of Michigan Medical Center, Ann Arbor 48109, USA
    Chest 118:492-502. 2000
    ..To evaluate the causes, risk factors, and mortality rates associated with unexpected readmission to medical and surgical ICUs...
  21. doi Decontamination of the digestive tract and oropharynx in ICU patients
    A M G A de Smet
    Division of Perioperative and Emergency Care, University Medical Center, Utrecht, The Netherlands
    N Engl J Med 360:20-31. 2009
    ....
  22. doi Impact of the Surviving Sepsis Campaign protocols on hospital length of stay and mortality in septic shock patients: results of a three-year follow-up quasi-experimental study
    Alvaro Castellanos-Ortega
    Intensive Care Medicine Department, Hospital Universitario Marques de Valdecilla, Santander, Spain
    Crit Care Med 38:1036-43. 2010
    ..To describe the effectiveness of the Surviving Sepsis Campaign bundles with regard to both implementation and outcome in patients with septic shock and to determine the contribution of the various elements of the bundles to the outcome...
  23. ncbi Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial
    Tim C Jansen
    Department of Intensive Care, Erasmus MC University Medical Centre, Rotterdam, The Netherlands
    Am J Respir Crit Care Med 182:752-61. 2010
    ..It is unknown whether lactate monitoring aimed to decrease levels during initial treatment in critically ill patients improves outcome...
  24. doi Procalcitonin-guided algorithms of antibiotic therapy in the intensive care unit: a systematic review and meta-analysis of randomized controlled trials
    Petros Kopterides
    Second Critical Care Department, Attiko University Hospital, University of Athens Medical School, Athens, Greece
    Crit Care Med 38:2229-41. 2010
    ..We sought to determine the effectiveness and safety of procalcitonin-guided algorithms in the management of septic patients in the intensive care unit...
  25. ncbi Antimicrobial susceptibility among gram-negative isolates collected from intensive care units in North America, Europe, the Asia-Pacific Rim, Latin America, the Middle East, and Africa between 2004 and 2009 as part of the Tigecycline Evaluation and Survei
    Xavier Bertrand
    Centre Hospitalier Universitaire Besançon, Besancon, France
    Clin Ther 34:124-37. 2012
    ..The Tigecycline Evaluation and Surveillance Trial is an antimicrobial susceptibility surveillance program that collects gram-positive and gram-negative organisms globally...
  26. ncbi Clinical outcomes of health-care-associated infections and antimicrobial resistance in patients admitted to European intensive-care units: a cohort study
    Marie Laurence Lambert
    Public Health and Surveillance Department, Scientific Institute for Public Health, Brussels, Belgium
    Lancet Infect Dis 11:30-8. 2011
    ..We aimed to assess excess mortality and length of stay in intensive-care units from bloodstream infections and pneumonia...
  27. ncbi Procalcitonin algorithms for antibiotic therapy decisions: a systematic review of randomized controlled trials and recommendations for clinical algorithms
    Philipp Schuetz
    Department of Emergency Medicine, Harvard School of Public Health, Boston, MA 02115, USA
    Arch Intern Med 171:1322-31. 2011
    ..We propose specific procalcitonin algorithms for low-, moderate-, and high-acuity patients as a basis for future trials aiming at reducing antibiotic overconsumption...
  28. ncbi Universal surveillance for methicillin-resistant Staphylococcus aureus in 3 affiliated hospitals
    Ari Robicsek
    Evanston Northwestern Healthcare and Northwestern University Feinberg School of Medicine, Evanston, Illinois 60201, USA
    Ann Intern Med 148:409-18. 2008
    ..The effect of large-scale expanded surveillance for methicillin-resistant Staphylococcus aureus (MRSA) on health care-associated MRSA disease is not known...
  29. doi A multifaceted intervention for quality improvement in a network of intensive care units: a cluster randomized trial
    Damon C Scales
    Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada
    JAMA 305:363-72. 2011
    ..Evidence-based practices improve intensive care unit (ICU) outcomes, but eligible patients may not receive them. Community hospitals treat most critically ill patients but may have few resources dedicated to quality improvement...
  30. pmc Delirium as a predictor of long-term cognitive impairment in survivors of critical illness
    Timothy D Girard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, and Department of Medicine, Saint Thomas Hospital, Nashville, TN, USA
    Crit Care Med 38:1513-20. 2010
    ..To test the hypothesis that duration of delirium in the intensive care unit is an independent predictor of long-term cognitive impairment after critical illness requiring mechanical ventilation...
  31. ncbi Changes in the epidemiology of methicillin-resistant Staphylococcus aureus in intensive care units in US hospitals, 1992-2003
    R Monina Klevens
    Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 42:389-91. 2006
    ..9% in 1992 to 64.4% in 2003 for hospitals in the National Nosocomial Infections Surveillance system. During the same period, there was a decrease in resistance rates for several non- beta -lactam drugs among the MRSA isolates...
  32. ncbi Different assessment tools for intensive care unit delirium: which score to use?
    Alawi Luetz
    Department of Anesthesiology and Intensive Care Medicine, Campus Virchow Klinikum, Charite Universitaetsmedizin Berlin, Berlin, Germany
    Crit Care Med 38:409-18. 2010
    ..Currently, there are several assessment tools available for detection of delirium, but only a few of these assessment systems are developed specifically to screen for delirium in ICU patients...
  33. doi Active cytomegalovirus infection is common in mechanically ventilated medical intensive care unit patients
    Laurent Chiche
    Service de Reanimation Medicale, Hopital Sainte Marguerite, URMITE UMR CNRS 6236, Universite de la Mediterranee, Marseille, France
    Crit Care Med 37:1850-7. 2009
    ..To assess the incidence, risk factors, and outcome of active cytomegalovirus (CMV) infection in nonimmunosuppressed intensive care unit (ICU) patients...
  34. ncbi The impact of delirium in the intensive care unit on hospital length of stay
    E W Ely
    Departments of Internal Medicine, Divisions of General Internal Medicine and Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
    Intensive Care Med 27:1892-900. 2001
    ..To determine the relationship between delirium in the intensive care unit (ICU) and outcomes including length of stay in the hospital...
  35. doi Guidelines for evaluation of new fever in critically ill adult patients: 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of America
    NAOMI P O'GRADY
    National Institutes of Health, Bethesda, MD, USA
    Crit Care Med 36:1330-49. 2008
    ..To update the practice parameters for the evaluation of adult patients who develop a new fever in the intensive care unit, for the purpose of guiding clinical practice...
  36. pmc Assessing the role of undetected colonization and isolation precautions in reducing methicillin-resistant Staphylococcus aureus transmission in intensive care units
    Theodore Kypraios
    School of Mathematical Sciences, University of Nottingham, Nottingham, UK
    BMC Infect Dis 10:29. 2010
    ..Recent methodological developments have made it possible to estimate these quantities using routine surveillance data...
  37. doi Risk factors and outcome of transfusion-related acute lung injury in the critically ill: a nested case-control study
    Alexander P J Vlaar
    Intensive Care Department, Academic Medical Center, Amsterdam, The Netherlands
    Crit Care Med 38:771-8. 2010
    ..To determine the incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of critically ill patients...
  38. ncbi Eliminating catheter-related bloodstream infections in the intensive care unit
    Sean M Berenholtz
    Departments of Anesthesiology CCM and Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Crit Care Med 32:2014-20. 2004
    ..To determine whether a multifaceted systems intervention would eliminate catheter-related bloodstream infections (CR-BSIs)...
  39. ncbi Epidemiology of invasive candidiasis
    Maiken C Arendrup
    Department of Microbiological Surveillance and Research, Division of Microbiology and Diagnostics, Statens Serum Institute, Copenhagen, Denmark
    Curr Opin Crit Care 16:445-52. 2010
    ..This review covers candidaemia in numbers, susceptibility issues, host groups, risk factors and outcome...
  40. pmc Evaluation of SOFA-based models for predicting mortality in the ICU: A systematic review
    Lilian Minne
    Department of Medical Informatics, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Crit Care 12:R161. 2008
    ..To systematically review studies evaluating the performance of Sequential Organ Failure Assessment (SOFA)-based models for predicting mortality in patients in the intensive care unit (ICU)...
  41. ncbi The respiratory variation in inferior vena cava diameter as a guide to fluid therapy
    Marc Feissel
    Réanimation Médicale et Maladies Infectieuses, Centre Hospitalier de Belfort, Belfort, France
    Intensive Care Med 30:1834-7. 2004
    ..To investigate whether the respiratory variation in inferior vena cava diameter (DeltaD(IVC)) could be related to fluid responsiveness in mechanically ventilated patients...
  42. ncbi Isolation of patients in single rooms or cohorts to reduce spread of MRSA in intensive-care units: prospective two-centre study
    Jorge A Cepeda
    Department of Clinical Microbiology, University College London Hospitals, London W1T 4 JF, UK
    Lancet 365:295-304. 2005
    ..We aimed to assess the effectiveness of moving versus not moving infected or colonised patients in intensive-care units to prevent transmission of MRSA...
  43. ncbi Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: a randomized trial
    Jens U Jensen
    Copenhagen HIV Programme, University of Copenhagen, Copenhagen, Denmark
    Crit Care Med 39:2048-58. 2011
    For patients in intensive care units, sepsis is a common and potentially deadly complication and prompt initiation of appropriate antimicrobial therapy improves prognosis...
  44. pmc Nonrecovery of kidney function and death after acute on chronic renal failure
    Chi yuan Hsu
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    Clin J Am Soc Nephrol 4:891-8. 2009
    ..Relatively little is known about clinical outcomes, especially long-term outcomes, among patients who have chronic kidney disease (CKD) and experience superimposed acute renal failure (ARF; acute on chronic renal failure)...
  45. pmc Circulating soluble urokinase plasminogen activator receptor is stably elevated during the first week of treatment in the intensive care unit and predicts mortality in critically ill patients
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 15:R63. 2011
    ....
  46. pmc Decreasing mortality in severe sepsis and septic shock patients by implementing a sepsis bundle in a hospital setting
    Sandra Christina Pereira Lima Shiramizo
    Critical Care Unit, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
    PLoS ONE 6:e26790. 2011
    ..The Surviving Sepsis Campaign (SSC) guidelines for the management of severe sepsis (SS) and septic shock (SSh) have been recommended to reduce morbidity and mortality...
  47. doi Permissive underfeeding and intensive insulin therapy in critically ill patients: a randomized controlled trial
    Yaseen M Arabi
    Department of Intensive Care Medicine, King Abdulaziz Medical City, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
    Am J Clin Nutr 93:569-77. 2011
    ..Nutritional support has been recognized as an essential part of intensive care unit management. However, the appropriate caloric intake for critically ill patients remains ill defined...
  48. pmc Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital
    Jia Chang Cai
    2nd Affiliated Hospital of Zhejiang University, 88 Jiefang Rd, Hangzhou, China 310009
    Antimicrob Agents Chemother 52:2014-8. 2008
    ..coli isolate with carbapenem resistance or reduced carbapenem susceptibility were recovered from intensive care units (ICUs) in our hospital...
  49. pmc Clinical review: scoring systems in the critically ill
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, Brussels, Belgium
    Crit Care 14:207. 2010
    ..All these scoring systems will need to be updated with time as ICU populations change and new diagnostic, therapeutic and prognostic techniques become available...
  50. doi Incidence of adverse drug events and medication errors in intensive care units: a prospective multicenter study
    Raja R Benkirane
    Moroccan Pharmacovigilance Centre, Rabat, Marocco
    J Patient Saf 5:16-22. 2009
    ....
  51. pmc Case fatality rates based on population estimates of influenza-like illness due to novel H1N1 influenza: New York City, May-June 2009
    James L Hadler
    Department of Health and Mental Hygiene, City of New York, New York, New York, United States of America
    PLoS ONE 5:e11677. 2010
    ..New York City (NYC) experienced an intensive initial outbreak that peaked in late May, providing the need and opportunity to rapidly quantify the severity of nH1N1...
  52. ncbi Acute renal failure in patients with sepsis in a surgical ICU: predictive factors, incidence, comorbidity, and outcome
    Eric A J Hoste
    Intensive Care Unit and Renal Unit, Ghent University Hospital, Gent, Belgium
    J Am Soc Nephrol 14:1022-30. 2003
    ..This model allows initiating specific therapeutic measures earlier in the course of sepsis, hopefully resulting in a lower incidence of ARF and needi for RRT, thereby lowering mortality...
  53. doi Severe maternal morbidity during pregnancy, delivery and puerperium in the Netherlands: a nationwide population-based study of 371,000 pregnancies
    J J Zwart
    Department of Obstetrics, Leiden University Medical Centre, Leiden, The Netherlands
    BJOG 115:842-50. 2008
    ..To assess incidence, case fatality rate, risk factors and substandard care in severe maternal morbidity in the Netherlands...
  54. pmc Regulation and prognostic relevance of serum ghrelin concentrations in critical illness and sepsis
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 14:R94. 2010
    ....
  55. ncbi An algorithm to estimate the importance of bacterial acquisition routes in hospital settings
    M C J Bootsma
    Department of Mathematics, Utrecht University, Utrecht, Kingdom of the Netherlands
    Am J Epidemiol 166:841-51. 2007
    ..of third-generation cephalosporin-resistant Enterobacteriaceae (CRE) from September 2001 to May 2002 in two intensive care units (ICUs) (n = 277 and n = 180, respectively) of Utrecht, Kingdom of the Netherlands...
  56. ncbi Acute renal failure in critically ill patients: a multinational, multicenter study
    Shigehiko Uchino
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    JAMA 294:813-8. 2005
    ....
  57. ncbi Low caloric intake is associated with nosocomial bloodstream infections in patients in the medical intensive care unit
    Lewis Rubinson
    Johns Hopkins University, Department of Medicine, Baltimore, MD, USA
    Crit Care Med 32:350-7. 2004
    ..To determine whether caloric intake is associated with risk of nosocomial bloodstream infection in critically ill medical patients...
  58. ncbi Limiting life-sustaining treatment in German intensive care units: a multiprofessional survey
    Ralf J Jox
    Interdisciplinary Center for Palliative Medicine, Munich University Hospital, Marchioninistrasse 15, D 81377 Munich, Germany
    J Crit Care 25:413-9. 2010
    ..The aim of the study was to investigate the practices and perspectives of German intensive care nurses and physicians on limiting LST...
  59. ncbi Hemodynamic monitoring in shock and implications for management. International Consensus Conference, Paris, France, 27-28 April 2006
    Massimo Antonelli
    Istituto di Anestesiologia e Rianimazione, Policlinico Universitario A Gemelli, Universita Cattolica del Sacro Cuore, Largo A Gemelli, 8, 00168 Rome, Italy
    Intensive Care Med 33:575-90. 2007
    ..The goal of this consensus statement is to provide recommendations regarding the monitoring and management of the critically ill patient with shock...
  60. pmc Cytomegalovirus reactivation in critically ill immunocompetent patients
    Ajit P Limaye
    Department of Laboratory Medicine, University of Washington Medical Center, 1959 NE Pacific St, Seattle, WA 98195 7110, USA
    JAMA 300:413-22. 2008
    ....
  61. ncbi Complications of femoral and subclavian venous catheterization in critically ill patients: a randomized controlled trial
    J Merrer
    Service de Reanimation Medicale, Hôpital de Poissy St Germain en Laye, 10 rue du Champ Gaillard, 78303 Poissy, France
    JAMA 286:700-7. 2001
    ..Whether venous catheterization at the femoral site is associated with an increased risk of complications compared with that at the subclavian site is debated...
  62. doi Critical care and the global burden of critical illness in adults
    Neill K J Adhikari
    Interdepartmental Division of Critical Care, University of Toronto and Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Lancet 376:1339-46. 2010
    ....
  63. doi Acquired weakness, handgrip strength, and mortality in critically ill patients
    Naeem A Ali
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Ohio State University, 473 W 12th Avenue, Columbus, OH 43221, USA
    Am J Respir Crit Care Med 178:261-8. 2008
    ..However, it is unclear whether ICUAP is independently associated with mortality, as sicker patients are more prone and existing studies have not adjusted for this...
  64. pmc Quality of life in the five years after intensive care: a cohort study
    Brian H Cuthbertson
    Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, M4N 3M5, Canada
    Crit Care 14:R6. 2010
    ..Data on quality of life beyond 2 years after intensive care discharge are limited and we aimed to explore this area further. Our objective was to quantify quality of life and health utilities in the 5 years after intensive care discharge...
  65. pmc Quality of life in patients aged 80 or over after ICU discharge
    Alexis Tabah
    Medical Surgical ICU, Saint Joseph Hospital Network, 185 rue Raymond Losserand, 75014 Paris, France
    Crit Care 14:R2. 2010
    ..Our objective was to describe self-sufficiency and quality of life one year after intensive care unit (ICU) discharge of patients aged 80 years or over...
  66. ncbi Metabolic acidosis in patients with severe sepsis and septic shock: a longitudinal quantitative study
    Danilo T Noritomi
    Intensive Care Unit, Hospital Universitario, University of Sao Paulo, Sao Paulo, Brazil
    Crit Care Med 37:2733-9. 2009
    ..To describe the composition of metabolic acidosis in patients with severe sepsis and septic shock at intensive care unit admission and throughout the first 5 days of intensive care unit stay...
  67. pmc Relative hyperlactatemia and hospital mortality in critically ill patients: a retrospective multi-centre study
    Alistair D Nichol
    Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital Campus, 75 Commercial Road, Prahran, VIC 31821, Australia
    Crit Care 14:R25. 2010
    ..We tested the hypothesis that relative hyperlactatemia is independently associated with an increased risk of hospital death...
  68. pmc Early acute kidney injury and sepsis: a multicentre evaluation
    Sean M Bagshaw
    Division of Critical Care Medicine, Faculty of Medicine and Dentistry, 3C1, 12 Walter C Mackenzie Centrel, University of Alberta Hospital, University of Alberta, 8440 112 St NW, Edmonton, Alberta, T6G2B7 Canada
    Crit Care 12:R47. 2008
    ..We conducted a study to evaluate the incidence, risk factors and outcomes associated with early acute kidney injury (AKI) in sepsis...
  69. ncbi Septic acute kidney injury in critically ill patients: clinical characteristics and outcomes
    Sean M Bagshaw
    Department of Intensive Care and Department of Medicine, Austin and Repatriation Medical Centre, Melbourne, Australia
    Clin J Am Soc Nephrol 2:431-9. 2007
    ..Patients with septic AKI had an increased risk for death and longer duration of hospitalization yet showed trends toward greater renal recovery and independence from RRT...
  70. ncbi The characteristics and prognostic importance of NT-ProBNP concentrations in critically ill patients
    Keyur B Shah
    University of Maryland School of Medicine, Baltimore, USA
    Am J Med 120:1071-7. 2007
    ..We evaluate amino-terminal brain natriuretic peptide (NT-proBNP) in the medical ICU, specifically its correlation with noncardiac admission diagnosis and prognosis of critically ill patients...
  71. ncbi Efficacy of an alcohol/chlorhexidine hand hygiene program in a hospital with high rates of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection
    Paul D R Johnson
    Austin Health, Studley Road, Heidelberg, Victoria 3084, Australia
    Med J Aust 183:509-14. 2005
    ..To assess the effect of a multifaceted hand hygiene culture-change program on health care worker behaviour, and to reduce the burden of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infections...
  72. ncbi Caloric intake in medical ICU patients: consistency of care with guidelines and relationship to clinical outcomes
    Jerry A Krishnan
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Chest 124:297-305. 2003
    ..To assess the consistency of caloric intake with American College of Chest Physicians (ACCP) recommendations for critically ill patients and to evaluate the relationship of caloric intake with clinical outcomes...
  73. ncbi Reduction in nosocomial infection with improved hand hygiene in intensive care units of a tertiary care hospital in Argentina
    Victor D Rosenthal
    Section of Infectious Diseases and Hospital Epidemiology, Colegiales Hospital, Buenos Aires, Argentina
    Am J Infect Control 33:392-7. 2005
    ..We attempted to enhance compliance with hand hygiene by implementing education, training, and performance feedback. We measured nosocomial infections in parallel...
  74. pmc Intervention to reduce transmission of resistant bacteria in intensive care
    W Charles Huskins
    Division of Pediatric Infectious Diseases, Mayo Clinic, Rochester, MN 55905, USA
    N Engl J Med 364:1407-18. 2011
    b>Intensive care units (ICUs) are high-risk settings for the transmission of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE).
  75. doi Incidence and outcomes of acute kidney injury in intensive care units: a Veterans Administration study
    Charuhas V Thakar
    Nephrology, Cincinnati VA Medical Center, Cincinnati, OH, USA
    Crit Care Med 37:2552-8. 2009
    ..Acute kidney injury in intensive care unit patients is associated with significant mortality...
  76. ncbi Effect of obesity on intensive care morbidity and mortality: a meta-analysis
    Morohunfolu E Akinnusi
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Western New York Respiratory Research Center, University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY, USA
    Crit Care Med 36:151-8. 2008
    ..To evaluate the effect of obesity on intensive care unit mortality, duration of mechanical ventilation, and intensive care unit length of stay among critically ill medical and surgical patients...
  77. ncbi Early enteral nutrition in acutely ill patients: a systematic review
    P E Marik
    Critical Care Medicine, The Mercy Hospital of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 29:2264-70. 2001
    ..The results of this meta-analysis must, however, be interpreted with some caution because of the significant heterogeneity between studies...
  78. doi Methicillin-resistant Staphylococcus aureus central line-associated bloodstream infections in US intensive care units, 1997-2007
    Deron C Burton
    Surveillance Branch, Division of Healthcare Quality Promotion, National Center for Preparedness, Detection, and Control of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    JAMA 301:727-36. 2009
    ..Concerns about rates of methicillin-resistant Staphylococcus aureus (MRSA) health care-associated infections have prompted calls for mandatory screening or reporting in efforts to reduce MRSA infections...
  79. ncbi Spectrum of acute renal failure in the intensive care unit: the PICARD experience
    Ravindra L Mehta
    Division of Nephrology, Department of Medicine, University of California San Diego, San Diego, California, USA
    Kidney Int 66:1613-21. 2004
    ..Understanding the changing spectrum of ARF will be necessary to facilitate quality improvement efforts and to design successful interventional trials...
  80. ncbi Nosocomial pneumonia after acute stroke: implications for neurological intensive care medicine
    Ruediger Hilker
    Department of Neurology, University Hospital, Cologne, Germany
    Stroke 34:975-81. 2003
    Pneumonia has been estimated to occur in about one third of patients after acute stroke. Only limited data are available on stroke-associated pneumonia (SAP) in specialized neurological intensive care units (NICUs).
  81. pmc Quality of interhospital transport of the critically ill: impact of a Mobile Intensive Care Unit with a specialized retrieval team
    Janke S Wiegersma
    Department of Critical Care, University Medical Center Groningen, Hanzeplein 1, PO Box 30, 001, 9700 RB Groningen, The Netherlands
    Crit Care 15:R75. 2011
    ..To evaluate the effects of this implementation, we performed a prospective audit comparing adverse events and patient stability during MICU transfers with our previous data on transfers performed by standard ambulance...
  82. ncbi Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome
    Andrew Davies
    FRACP, FJFICM, Intensive Care Unit, Alfred Hospital, Commercial Road, Melbourne, Victoria 3004, Australia
    JAMA 302:1888-95. 2009
    ..It caused an epidemic of critical illness and some patients developed severe acute respiratory distress syndrome (ARDS) and were treated with extracorporeal membrane oxygenation (ECMO)...
  83. ncbi Comparison of antimicrobial cycling and mixing strategies in two medical intensive care units
    Jose Antonio Martinez
    Department of Infectious Diseases, Hospital Clinic, IDIBAPS University of Barcelona, Spain
    Crit Care Med 34:329-36. 2006
    ..To compare a mixing vs. a cycling strategy of use of anti-Pseudomonas antibiotics on the acquisition of resistant Gram-negative bacilli in the critical care setting...
  84. doi Soluble form of the receptor for advanced glycation end products is a marker of acute lung injury but not of severe sepsis in critically ill patients
    Matthieu Jabaudon
    Department of Anesthesiology and Critical Care Medicine, Intensive Care Unit, Estaing University Hospital, CHU Clermont Ferrand, Clermont Ferrand, France
    Crit Care Med 39:480-8. 2011
    ..Whether sRAGE is a marker of acute lung injury and acute respiratory distress syndrome, regardless of associated severe sepsis or septic shock, remains unknown in the intensive care unit setting...
  85. doi Invasive fungal infections in the intensive care unit: a multicentre, prospective, observational study in Italy (2006-2008)
    Anna Maria Tortorano
    Dipartimento Sanità Pubblica Microbiologia Virologia, Universita degli Studi di Milano, Italy
    Mycoses 55:73-9. 2012
    Critically ill patients admitted to intensive care units (ICU) are highly susceptible to healthcare-associated infections caused by fungi...
  86. doi Procalcitonin to guide duration of antimicrobial therapy in intensive care units: a systematic review
    Rajender Agarwal
    Department of Medicine, Stroger Hospital of Cook County, Chicago, Illinois 60612, USA
    Clin Infect Dis 53:379-87. 2011
    ..Procalcitonin guidance of antimicrobial duration appears to decrease antimicrobial use in the ICU safely and significantly and may also decrease the length of stay in the ICU...
  87. doi Attributable mortality of ventilator-associated pneumonia: a reappraisal using causal analysis
    Maarten Bekaert
    Department of Applied Mathematics and Computer Sciences, Ghent University, Ghent, Belgium
    Am J Respir Crit Care Med 184:1133-9. 2011
    ..Measuring the attributable mortality of ventilator-associated pneumonia (VAP) is challenging and prone to different forms of bias. Studies addressing this issue have produced variable and controversial results...
  88. pmc Real-time continuous glucose monitoring in an intensive care unit: better accuracy in patients with septic shock
    Carol Lorencio
    Department of Intensive Care, University Hospital of Girona Doctor Josep Trueta, Girona, Spain
    Diabetes Technol Ther 14:568-75. 2012
    ..This study assessed the accuracy of real-time continuous glucose monitoring system (RTCGMS) devices in an intensive care unit (ICU) to determine whether the septic status of the patient has any influence on the accuracy of the RTCGMS...
  89. ncbi Clinical characteristics and outcomes of obstetric patients requiring ICU admission
    Daniela N Vasquez
    Intensive Care Unit, Hospital Interzonal General de Agudos Gral, San Martin, 1 y 70, 1900 La Plata, Buenos Aires, Argentina
    Chest 131:718-24. 2007
    ..To review a series of critically ill obstetric patients admitted to our ICU to assess the spectrum of disease, required interventions, and fetal/maternal mortality, and to identify conditions associated with maternal death...
  90. doi Epidemiology of critical care syndromes, organ failures, and life-support interventions in a suburban US community
    Rodrigo Cartin-Ceba
    Multidisciplinary Epidemiology and Translational Research in Intensive Care M E T R I C, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Chest 140:1447-55. 2011
    ..We aimed to determine the incidence of critical care syndromes, organ failures, and life-support interventions in a defined US suburban community with unrestricted access to critical care services...
  91. ncbi Improving methicillin-resistant Staphylococcus aureus surveillance and reporting in intensive care units
    Susan S Huang
    Brigham and Women s Hospital, Channing Laboratory and Infection Control Department, Harvard Medical School, and Harvard Pilgrim Health Care, Boston, MA 02115, USA
    J Infect Dis 195:330-8. 2007
    Routine culturing of patients in intensive care units (ICUs) for methicillin-resistant Staphylococcus aureus (MRSA) identifies unrecognized carriers and facilitates timely isolation...
  92. ncbi Quantitative assessment of the microcirculation in healthy volunteers and in patients with septic shock
    Vanina S Kanoore Edul
    Servicio de Terapia Intensiva, Sanatorio Otamendi y Miroli, Buenos Aires, Argentina
    Crit Care Med 40:1443-8. 2012
    ..Our hypotheses were that 1) hyperdynamic blood flow is absent in septic shock; 2) nonsurvivors show more severe alterations than survivors; and 3) quantitative and semiquantitative microcirculatory parameters have a similar performance...
  93. ncbi Experience with the continuous glucose monitoring system in a medical intensive care unit
    Philip A Goldberg
    Section of Endocrinology, Department of Medicine, Yale New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
    Diabetes Technol Ther 6:339-47. 2004
    ..If further developed as a "real-time" glucose sensor, CGMS technology could ultimately prove clinically useful in the ICU, by decreasing nursing workload and/or by providing alarm signals for impending glycemic excursions...
  94. ncbi Obstetric admissions to the intensive care unit
    N G Mahutte
    Department of Obstetrics and Gynecology, the Royal Victoria General Hospital, McGill University, Montreal, Quebec, Canada
    Obstet Gynecol 94:263-6. 1999
    ..To determine whether obstetric admissions to the intensive care unit (ICU) are useful quality-assurance indicators...
  95. pmc SAPS 3--From evaluation of the patient to evaluation of the intensive care unit. Part 2: Development of a prognostic model for hospital mortality at ICU admission
    Rui P Moreno
    Unidade de Cuidados Intensivos Polivalente, Hospital de St António dos Capuchos, Centro Hospitalar de Lisboa zona central, Lisbon, Portugal
    Intensive Care Med 31:1345-55. 2005
    ..To develop a model to assess severity of illness and predict vital status at hospital discharge based on ICU admission data...
  96. ncbi Impact of clinical guidelines in the management of severe hospital-acquired pneumonia
    Guy W Soo Hoo
    Pulmonary and Critical Care Section 111Q, West Los Angeles Healthcare Center, VA Greater Los Angeles Healthcare System, Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90073, USA
    Chest 128:2778-87. 2005
    ..To asses the impact of locally developed antimicrobial treatment guidelines in the initial empiric treatment of ICU patients with severe hospital-acquired pneumonia (HAP)...
  97. doi Gender impact on the outcomes of critically ill patients with nosocomial infections
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Crit Care Med 37:2506-11. 2009
    ..Highly controversial data exist regarding gender-related differences in outcomes of severe nosocomial infections, reflecting potential confounders related to case-mixes or heterogeneity of populations evaluated...
  98. doi Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection
    I Martin-Loeches
    Critical Care Department, Joan XXIII University Hospital, University Rovira i Virgili, IISPV, CIBER Enfermedades Respiratorias CIBERES, Tarragona, Spain
    Intensive Care Med 37:272-83. 2011
    ..Early use of corticosteroids in patients affected by pandemic (H1N1)v influenza A infection, although relatively common, remains controversial...
  99. doi Community-acquired respiratory coinfection in critically ill patients with pandemic 2009 influenza A(H1N1) virus
    Ignacio Martin-Loeches
    Critical Care Department, Joan XXIII University Hospital, University Rovira i Virgili, CibeRes, Mallafre Guasch 4, 43007 Tarragona, Spain
    Chest 139:555-62. 2011
    ..Little is known about the impact of community-acquired respiratory coinfection in patients with pandemic 2009 influenza A(H1N1) virus infection...
  100. doi Therapeutic drug monitoring of beta-lactams in critically ill patients: proof of concept
    Jason A Roberts
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
    Int J Antimicrob Agents 36:332-9. 2010
    ..05) were found to be predictive of mortality. In conclusion, further research is required to determine definitively whether achievement of optimal beta-lactam pharmacodynamic targets improves clinical outcomes...
  101. pmc One-year trajectories of care and resource utilization for recipients of prolonged mechanical ventilation: a cohort study
    Mark Unroe
    Duke University, Durham, North Carolina 27710, USA
    Ann Intern Med 153:167-75. 2010
    ..Little is known about the patterns of care as patients transition from acute care hospitals to postacute care facilities or about the associated resource utilization...

Research Grants86

  1. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    T O SHEA; Fiscal Year: 2005
    ..in this region there are approximately 20,000 births, including 1400 who are admitted to the WFUSM neonatal intensive care units, and 270 who are very low birth weight...
  2. Bilirubin-induced Auditory Neuropathy in Preterms
    SANJIV AMIN; Fiscal Year: 2007
    ..The OAE reflects cochlear function and is the current standard of care in many Neonatal Intensive Care Units (NICU) for hearing screening...
  3. Effects of Noise on Newborns < 1000g Birthweight
    Robert Lasky; Fiscal Year: 2007
    Noise levels in neonatal intensive care units (NICUs) may have serious adverse effects on high risk infants by increasing apneic, bradycardic, or desaturation episodes; sleep disturbances; mechanical ventilation; hospital stay; poor ..
  4. Biomarker Profiles for Early Diagnosis of Sepsis in Neonates
    James Mapes; Fiscal Year: 2007
    Sepsis is a frequent and serious problem in neonatal intensive care units, particularly in very low birth weight (VLBW) infants. Over 20% of all VLBW infants experience one or more episodes of late-onset sepsis...
  5. Prevention of Nosocomial Infections and Cost-Effectiveness Refined (P-NICER)
    Patricia W Stone; Fiscal Year: 2010
    ..major contributor to increased morbidity, mortality and hospital costs;and, the majority of these occur in intensive care units (ICUs) and many are associated with insertion of an invasive device...
  6. Intrathoracic Pressure Regulation for the Treatment of Septic Shock
    Keith Lurie; Fiscal Year: 2009
    ..the treatment of patients with sepsis, sepsis remains the second most common cause of death in non-coronary intensive care units and the tenth leading cause of death overall in high-income countries...
  7. DEVELOPMENT EFFECT ON LOOP DIURETIC OTOTOXICITY
    Leonard Rybak; Fiscal Year: 1999
    Loop diuretics are widely used to treat premature infants in neonatal intensive care units. Recent reports have suggested an increased risk of permanent sensorineural hearing loss among infants receiving such treatments...
  8. Neonatal APD, a Simple Noninvasive Diagnostic/Monitoring Device for Neonatal ICU
    JAFAR VOSSOUGHI; Fiscal Year: 2010
    ..These preterm infants (500 to 1,500 g birth weight) remain in Neonatal Intensive Care Units (NICUs) for extended periods and often receive a variety of potentially toxic medications for their lung ..
  9. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Maragakis; Fiscal Year: 2009
    ..increasingly the cause of a variety of serious infections in hospitalized patients, particularly those in intensive care units. Therapeutic choices for these infections are severely limited since many of these MDR organisms have ..
  10. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Maragakis; Fiscal Year: 2007
    ..increasingly the cause of a variety of serious infections in hospitalized patients, particularly those in intensive care units. Therapeutic choices for these infections are severely limited since many of these MDR organisms have ..
  11. AMELIORATION OF SEPSIS BY MACROPHAGE ACTIVATION
    David Williams; Fiscal Year: 1999
    ..advances in critical care, sepsis continues to be a pivotal factor in 40% to 60% of deaths in surgical intensive care units. Sepsis syndrome occurs in 500,000 patients per year and is the 13th most common cause of death in the ..
  12. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    T O SHEA; Fiscal Year: 2001
    ..in this region there are approximately 20,000 births, including 1400 who are admitted to the WFUSM neonatal intensive care units, and 270 who are very low birth weight...
  13. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    T O SHEA; Fiscal Year: 2003
    ..in this region there are approximately 20,000 births, including 1400 who are admitted to the WFUSM neonatal intensive care units, and 270 who are very low birth weight...
  14. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    T O SHEA; Fiscal Year: 2004
    ..in this region there are approximately 20,000 births, including 1400 who are admitted to the WFUSM neonatal intensive care units, and 270 who are very low birth weight...
  15. Palliation of Thirst in Intensive Care Unit Patients
    Kathleen Puntillo; Fiscal Year: 2009
    ..most pervasive, intense, unrecognized, and under-treated symptoms suffered by critically ill patients in Intensive Care Units (ICUs)...
  16. Mechanisms of Novel Herbal Therapies for Sepsis.
    Haichao Wang; Fiscal Year: 2010
    ..advance in antibiotic therapy and intensive care, sepsis remains the most common cause of death in the intensive care units, claiming >225,000 victims annually in the U.S. alone...
  17. Cooperative Multicenter Neonatal Research Network
    T O SHEA; Fiscal Year: 2002
    ..in this region there are approximately 20,000 births, including 1400 who are admitted to the WFUSM neonatal intensive care units, and 270 who are very low birth weight...
  18. Accelerating Adoption of Comparative Effectiveness Research in Premature Infants
    Phillip Brian Smith; Fiscal Year: 2010
    ..medical record, along with patient-level data on demographics to identify the worst-performing neonatal intensive care units for each of the AIMs. We will then use specific educational interventions for these poor-performing units...
  19. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    James Lemons; Fiscal Year: 1991
    ..The section has experience with and is supportive of a capitation system for funding of specific protocols and is anxious to participate in multicenter trials...
  20. Efficacy of clonidine in reducing iatrogenic-induced opioid dependence in infants
    Estelle B Gauda; Fiscal Year: 2011
    ..and benzodiazepines to achieve sedation and analgesia as part of routine care in neonatal and pediatric intensive care units. While the use of these agents are undisputedly beneficial in reducing pain and anxiety, improving ..
  21. Efficacy of clonidine in reducing iatrogenic-induced opioid dependence in infants
    Estelle B Gauda; Fiscal Year: 2010
    ..and benzodiazepines to achieve sedation and analgesia as part of routine care in neonatal and pediatric intensive care units. While the use of these agents are undisputedly beneficial in reducing pain and anxiety, improving ..
  22. Biomarker Profiles for Early Diagnosis of Sepsis in Neonates
    James Mapes; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Sepsis is a frequent and serious problem in neonatal intensive care units, particularly in very low birth weight (VLBW) infants...
  23. Biomarker Profiles for Early Diagnosis of Sepsis in Neonates
    JAMES PRESTON MAPES; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Sepsis is a frequent and serious problem in neonatal intensive care units, particularly in very low birth weight (VLBW) infants...
  24. Biomarker Profiles for Early Diagnosis of Sepsis in Neonates
    James Mapes; Fiscal Year: 2009
    Project Summary/Abstract: Sepsis is a frequent and serious problem in neonatal intensive care units, particularly in very low birth weight (VLBW) infants. Over 20% of all VLBW infants experience one or more episodes of late-onset sepsis...
  25. Applied Research in Antimicrobial Resistance: Studies of Susceptibility Testing
    Lisa Saiman; Fiscal Year: 2007
    ..the 'post-antimicrobial era' has been looming for well over a decade as patients, particularly in intensive care units (ICUs), are increasingly developing infections caused by multidrug-resistant (MDR) pathogens...
  26. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Saiman; Fiscal Year: 2009
    ..the 'post-antimicrobial era'has been looming for well over a decade as patients, particularly in intensive care units (ICUs), are increasingly developing infections caused by multidrug-resistant (MDR) pathogens...
  27. Detection of Antibiotic Resistance Genes in Bacterial Agents of Hospital-Acquired
    Andrew Levin; Fiscal Year: 2009
    ..and sepsis are leading causes of morbidity and mortality in critically ill patients, especially in hospital intensive care units. These acute conditions are caused by infection with a range of Gram-positive and Gram-negative bacteria ..
  28. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    James Lemons; Fiscal Year: 2003
    ..Indiana University brings to the Neonatal Network a large patient population, a uniquely balanced program of clinical service and research, and a strong record of participation and accomplishment. ..
  29. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    James Lemons; Fiscal Year: 2005
    ..Indiana University brings to the Neonatal Network a large patient population, a uniquely balanced program of clinical service and research, and a strong record of participation and accomplishment. ..
  30. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    James Lemons; Fiscal Year: 2004
    ..Indiana University brings to the Neonatal Network a large patient population, a uniquely balanced program of clinical service and research, and a strong record of participation and accomplishment. ..
  31. Plasma iNOS IVD Prognosticates Sepsis Prior to Organ Damage and Dysfunction
    Robert J Webber; Fiscal Year: 2010
    ..development project are [1] to conduct a clinical study on 560 subjects, 360 trauma patients admitted to intensive care units (ICUs) at three regional trauma centers and 200 exempt "unlinked, diagnostic specimens" from normal healthy ..
  32. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    James Lemons; Fiscal Year: 2001
    ..Indiana University brings to the Neonatal Network a large patient population, a uniquely balanced program of clinical service and research, and a strong record of participation and accomplishment. ..
  33. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    Charles Bauer; Fiscal Year: 2000
    ....
  34. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    Charles Bauer; Fiscal Year: 1999
    ....
  35. An Innovative Hearing Loss Prevention Approach For Infant Incubator
    Xun Yu; Fiscal Year: 2009
    Infant incubators are widely used in neonatal intensive care units (NICU) for the care of pre-term babies, as they cannot cope with the environment without external help...
  36. Effects of Noise on Newborns < 1000g Birthweight
    Robert Lasky; Fiscal Year: 2006
    Noise levels in neonatal intensive care units (NICUs) may have serious adverse effects on high risk infants by increasing apneic, bradycardic, or desaturation episodes; sleep disturbances; mechanical ventilation; hospital stay; poor ..
  37. Effects of Noise on Newborns < 1000g Birthweight
    Robert Lasky; Fiscal Year: 2005
    Noise levels in neonatal intensive care units (NICUs) may have serious adverse effects on high risk infants by increasing apneic, bradycardic, or desaturation episodes; sleep disturbances; mechanical ventilation; hospital stay; poor ..
  38. Effects of Noise on Newborns < 1000g Birthweight
    Robert Lasky; Fiscal Year: 2004
    Noise levels in neonatal intensive care units (NICUs) may have serious adverse effects on high risk infants by increasing apneic, bradycardic, or desaturation episodes; sleep disturbances; mechanical ventilation; hospital stay; poor ..
  39. Bilirubin-induced Auditory Neuropathy in Preterms
    SANJIV AMIN; Fiscal Year: 2006
    ..The OAE reflects cochlear function and is the current standard of care in many Neonatal Intensive Care Units (NICU) for hearing screening...
  40. Bilirubin-induced Auditory Neuropathy in Preterms
    SANJIV AMIN; Fiscal Year: 2005
    ..The OAE reflects cochlear function and is the current standard of care in many Neonatal Intensive Care Units (NICU) for hearing screening...
  41. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    Jon Tyson; Fiscal Year: 2005
    ..John C. Sinclair, MD, an eminent neonatologist, clinical epidemiologist, and Network advisor, will join the Center Jan. 2001. ..
  42. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    Jon Tyson; Fiscal Year: 2001
    ..John C. Sinclair, MD, an eminent neonatologist, clinical epidemiologist, and Network advisor, will join the Center Jan. 2001. ..
  43. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    Jon Tyson; Fiscal Year: 2004
    ..John C. Sinclair, MD, an eminent neonatologist, clinical epidemiologist, and Network advisor, will join the Center Jan. 2001. ..
  44. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    Jon Tyson; Fiscal Year: 2003
    ..John C. Sinclair, MD, an eminent neonatologist, clinical epidemiologist, and Network advisor, will join the Center Jan. 2001. ..
  45. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    Jon Tyson; Fiscal Year: 2003
    ..John C. Sinclair, MD, an eminent neonatologist, clinical epidemiologist, and Network advisor, will join the Center Jan. 2001. ..
  46. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    Jon Tyson; Fiscal Year: 2002
    ..John C. Sinclair, MD, an eminent neonatologist, clinical epidemiologist, and Network advisor, will join the Center Jan. 2001. ..
  47. Standardized Rehabilitation for ICU Patients with Acute Respiratory Failure
    Peter E Morris; Fiscal Year: 2010
    ..1 million of the 4.4 million people admitted to US Intensive Care Units (ICU) every year...
  48. Standardized Rehabilitation for ICU Patients with Acute Respiratory Failure
    Peter Morris; Fiscal Year: 2009
    ..1 million of the 4.4 million people admitted to US Intensive Care Units (ICU) every year...
  49. The Effects of Neonatal Intensive Care Deregionalization on Treatment and Infant
    SETH FREEDMAN; Fiscal Year: 2009
    DESCRIPTION (provided by the applicant): Neonatal Intensive Care Units (NICUs) have greatly improved health outcomes for sick, preterm, and underweight infants...
  50. NEOPAIN MULTICENTER TRIAL: DATA COORDINATING CENTER
    Bruce Barton; Fiscal Year: 2001
    ..Analgesic practices recorded prospectively in 109 Neonatal Intensive Care Units (NICUs) showed that opioids and benzodiazepines were most commonly used, with large variations in clinical ..
  51. Mesenteric Lymph Linking Gut & Distant Organ Injury
    Edwin Deitch; Fiscal Year: 2009
    Trauma is the leading cause of death in people under the age of 40 and MODS is the leading cause of death in intensive care units. Consequently, understanding the mechanisms by which trauma-hemorrhagic shock (T/HS) leads to MODS is of ..
  52. Mesenteric Lymph Linking Gut & Distant Organ Injury
    Edwin Deitch; Fiscal Year: 2007
    Trauma is the leading cause of death in people under the age of 40 and MODS is the leading cause of death in intensive care units. Consequently, understanding the mechanisms by which trauma-hemorrhagic shock (T/HS) leads to MODS is of ..
  53. Mesenteric Lymph Linking Gut & Distant Organ Injury
    Edwin Deitch; Fiscal Year: 2007
    Trauma is the leading cause of death in people under the age of 40 and MODS is the leading cause of death in intensive care units. Consequently, understanding the mechanisms by which trauma-hemorrhagic shock (T/HS) leads to MODS is of ..
  54. NEOPAIN MULTICENTER TRIAL: DATA COORDINATING CENTER
    Bruce Barton; Fiscal Year: 1999
    ..Analgesic practices recorded prospectively in 109 Neonatal Intensive Care Units (NICUs) showed that opioids and benzodiazepines were most commonly used, with large variations in clinical ..
  55. NEOPAIN MULTICENTER TRIAL: DATA COORDINATING CENTER
    Bruce Barton; Fiscal Year: 2000
    ..Analgesic practices recorded prospectively in 109 Neonatal Intensive Care Units (NICUs) showed that opioids and benzodiazepines were most commonly used, with large variations in clinical ..
  56. Mesenteric Lymph Linking Gut & Distant Organ Injury
    Edwin Deitch; Fiscal Year: 2006
    Trauma is the leading cause of death in people under the age of 40 and MODS is the leading cause of death in intensive care units. Consequently, understanding the mechanisms by which trauma-hemorrhagic shock (T/HS) leads to MODS is of ..
  57. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    William Oh; Fiscal Year: 1991
    ....
  58. SPECIAL CARE UNIT MODEL FOR LONG-TERM CRITICALLY ILL
    Barbara Daly; Fiscal Year: 1991
    ..comparing those cared for in a nurse-managed Special Care Unit (SCU) to those cared for in traditional intensive care units (ICU's)...
  59. IMPROVING BREASTFEEDING IN LOW BIRTHWEIGHT INFANTS AFTER HOSPITAL DISCHARGE
    Frank Greer; Fiscal Year: 2000
    ..very low birth weight (VLBW) infants (birth weight < 1500 grams) is now a goal for most newborn intensive care units (NlCUs) in the USA...
  60. Decreasing Bioburden to Reduce Healthcare-Associated Infections and Readmissions
    Richard Platt; Fiscal Year: 2012
    ..Studies in intensive care units (ICUs) indicate that decolonization of patients'skin with chlorhexidine, and nares with mupirocin can ..
  61. Identifying Effective Strategies to Disclose Prognosis in Patients with ARDS
    Douglas B White; Fiscal Year: 2010
    ..Three decades of research on end-of-life care in the United States indicates that Americans dying in intensive care units often spend their final days receiving life sustaining treatment they would not choose...
  62. Platelet Transfusions in the Neonatal Intensive Care Unit
    Martha Sola Visner; Fiscal Year: 2007
    ..is a common problem among sick newborn infants, affecting 20-35% of all patients admitted to Neonatal Intensive Care Units (NICUs)...
  63. Identifying Effective Strategies to Disclose Prognosis in Patients with ARDS
    Douglas White; Fiscal Year: 2009
    ..Three decades of research on end-of-life care in the United States indicates that Americans dying in intensive care units often spend their final days receiving life sustaining treatment they would not choose...
  64. MICROVASCULAR ABNORMALITIES IN SEPSIS
    Steven Hollenberg; Fiscal Year: 2002
    Septic shock, the leading cause of death in intensive care units, is characterized by vasodilation with decreased peripheral vascular resistance, which is often refractory to exogenously administered vasopressor agents...
  65. DEVELOPING CIRCADIAN RHYTHMICITY
    Scott Rivkees; Fiscal Year: 2002
    ..In neonatal intensive care units, preterm infants are typically exposed to continuous dim lighting without photic time-of-day cues...
  66. Core--Clinical and biostatistical
    Linda Van Marter; Fiscal Year: 2001
    ..Environment: Two Harvard-affiliated newborn intensive care units (NICUs) provide the source populations for SCOR clinical studies...
  67. DEVELOPING CIRCADIAN RHYTHMICITY
    Scott Rivkees; Fiscal Year: 2000
    ..In neonatal intensive care units, preterm infants are typically exposed to continuous dim lighting without photic time-of-day cues...
  68. MICROVASCULAR ABNORMALITIES IN SEPSIS
    Steven Hollenberg; Fiscal Year: 2002
    Septic shock, the leading cause of death in intensive care units, is characterized by vasodilation with decreased peripheral vascular resistance, which is often refractory to exogenously administered vasopressor agents...
  69. DEVELOPING CIRCADIAN RHYTHMICITY
    Scott Rivkees; Fiscal Year: 1999
    ..In neonatal intensive care units, preterm infants are typically exposed to continuous dim lighting without photic time-of-day cues...
  70. MICROVASCULAR ABNORMALITIES IN SEPSIS
    Steven Hollenberg; Fiscal Year: 1999
    Septic shock, the leading cause of death in intensive care units, is characterized by vasodilation with decreased peripheral vascular resistance, which is often refractory to exogenously administered vasopressor agents...
  71. Core--Clinical and biostatistical
    Linda Van Marter; Fiscal Year: 2002
    ..Environment: Two Harvard-affiliated newborn intensive care units (NICUs) provide the source populations for SCOR clinical studies...
  72. MICROVASCULAR ABNORMALITIES IN SEPSIS
    Steven Hollenberg; Fiscal Year: 2001
    Septic shock, the leading cause of death in intensive care units, is characterized by vasodilation with decreased peripheral vascular resistance, which is often refractory to exogenously administered vasopressor agents...
  73. MICROVASCULAR ABNORMALITIES IN SEPSIS
    Steven Hollenberg; Fiscal Year: 2000
    Septic shock, the leading cause of death in intensive care units, is characterized by vasodilation with decreased peripheral vascular resistance, which is often refractory to exogenously administered vasopressor agents...
  74. DEVELOPING CIRCADIAN RHYTHMICITY
    Scott Rivkees; Fiscal Year: 2001
    ..In neonatal intensive care units, preterm infants are typically exposed to continuous dim lighting without photic time-of-day cues...
  75. EFFECTS OF GENTLE HUMAN TOUCH ON PRETERM INFANTS
    Lynda Harrison; Fiscal Year: 1993
    ..Because of concerns about preterm infants' inabilities to cope with excessive stimulation, many neonatal intensive care units (NICU's) have instituted minimal handling policies, limiting the amount of handling provided to ..
  76. Bilirubin-induced Auditory Neuropathy in Preterms
    SANJIV AMIN; Fiscal Year: 2004
    ..The OAE reflects cochlear function and is the current standard of care in many Neonatal Intensive Care Units (NICU) for hearing screening...
  77. Bilirubin-induced Auditory Neuropathy in Preterms
    SANJIV AMIN; Fiscal Year: 2005
    ..The OAE reflects cochlear function and is the current standard of care in many Neonatal Intensive Care Units (NICU) for hearing screening...
  78. Novel Complementary Therapy for Preterm Infants
    John Bauer; Fiscal Year: 2009
    ..these conditions is necrotizing enterocolitis (NEC), a major cause of morbidity and mortality in neonatal intensive care units, is a disease for which there is currently no medical treatment...
  79. PROGRAMMED CELL DEATH--ROLE IN SEPTIC IMMUNE SUPPRESSION
    Alfred Ayala; Fiscal Year: 1999
    ..of trauma patients, sepsis and multiple organ failure continue to be a major problem in the surgical intensive care units. Thus, it is essential to determine the mechanism underlying the pathophysiology of sepsis so that more ..
  80. NICHD Cooperative Multicenter Neonatal Research Network
    Michele Walsh; Fiscal Year: 2006
    Case Western Reserve University has been a leading member of the Multicenter Network of Neonatal Intensive Care Units since 1986...