intensive care units

Summary

Summary: Hospital units providing continuous surveillance and care to acutely ill patients.

Top Publications

  1. ncbi Critically ill patients readmitted to intensive care units--lessons to learn?
    Philipp G H Metnitz
    Département Réanimation Médicale, Hopital St Louis, Universite Paris VII, Paris, France
    Intensive Care Med 29:241-8. 2003
  2. ncbi Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    D C Angus
    Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, and the Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 29:1303-10. 2001
  3. ncbi Critically ill patients with 2009 influenza A(H1N1) infection in Canada
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre, JJ 399, 700 William Ave, Winnipeg, MB R3E 0Z3 Canada
    JAMA 302:1872-9. 2009
  4. ncbi International study of the prevalence and outcomes of infection in intensive care units
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    JAMA 302:2323-9. 2009
  5. ncbi Sepsis in European intensive care units: results of the SOAP study
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Med 34:344-53. 2006
  6. ncbi Acute renal failure in critically ill patients: a multinational, multicenter study
    Shigehiko Uchino
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    JAMA 294:813-8. 2005
  7. ncbi An intervention to decrease catheter-related bloodstream infections in the ICU
    Peter Pronovost
    School of Medicine, Johns Hopkins University, Baltimore, USA
    N Engl J Med 355:2725-32. 2006
  8. ncbi Comparison of two fluid-management strategies in acute lung injury
    Herbert P Wiedemann
    Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, 9500 Euclid Ave, Desk A 90, Cleveland, OH 44195, USA
    N Engl J Med 354:2564-75. 2006
  9. ncbi A comparison of albumin and saline for fluid resuscitation in the intensive care unit
    Simon Finfer
    ANZICS CTG, Level 3, 10 Ievers St, Carlton, VIC 3053, Australia
    N Engl J Med 350:2247-56. 2004
  10. ncbi Incidence and prognosis of intraabdominal hypertension in a mixed population of critically ill patients: a multiple-center epidemiological study
    Manu L N G Malbrain
    Intensive Care Unit Director, Medical Intensive Care Unit, Ziekenhuis Netwerk Antwerpen, Campus Stuivenberg, Lange Beeldekensstraat 267, B 2060 Antwerpen 6, Belgium
    Crit Care Med 33:315-22. 2005

Detail Information

Publications327 found, 100 shown here

  1. ncbi Critically ill patients readmitted to intensive care units--lessons to learn?
    Philipp G H Metnitz
    Département Réanimation Médicale, Hopital St Louis, Universite Paris VII, Paris, France
    Intensive Care Med 29:241-8. 2003
    ..To evaluate risk factors in critically ill patients who were readmitted to an intensive care unit (ICU) during their hospital stay...
  2. ncbi Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    D C Angus
    Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, and the Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 29:1303-10. 2001
    ..To determine the incidence, cost, and outcome of severe sepsis in the United States...
  3. ncbi Critically ill patients with 2009 influenza A(H1N1) infection in Canada
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre, JJ 399, 700 William Ave, Winnipeg, MB R3E 0Z3 Canada
    JAMA 302:1872-9. 2009
    ..Between March and July 2009, the largest number of confirmed cases of 2009 influenza A(H1N1) infection occurred in North America...
  4. ncbi International study of the prevalence and outcomes of infection in intensive care units
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    JAMA 302:2323-9. 2009
    Infection is a major cause of morbidity and mortality in intensive care units (ICUs) worldwide. However, relatively little information is available about the global epidemiology of such infections.
  5. ncbi Sepsis in European intensive care units: results of the SOAP study
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Med 34:344-53. 2006
    To better define the incidence of sepsis and the characteristics of critically ill patients in European intensive care units.
  6. ncbi Acute renal failure in critically ill patients: a multinational, multicenter study
    Shigehiko Uchino
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    JAMA 294:813-8. 2005
    ....
  7. ncbi An intervention to decrease catheter-related bloodstream infections in the ICU
    Peter Pronovost
    School of Medicine, Johns Hopkins University, Baltimore, USA
    N Engl J Med 355:2725-32. 2006
    ..Catheter-related bloodstream infections occurring in the intensive care unit (ICU) are common, costly, and potentially lethal...
  8. ncbi Comparison of two fluid-management strategies in acute lung injury
    Herbert P Wiedemann
    Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, 9500 Euclid Ave, Desk A 90, Cleveland, OH 44195, USA
    N Engl J Med 354:2564-75. 2006
    ..Optimal fluid management in patients with acute lung injury is unknown. Diuresis or fluid restriction may improve lung function but could jeopardize extrapulmonary-organ perfusion...
  9. ncbi A comparison of albumin and saline for fluid resuscitation in the intensive care unit
    Simon Finfer
    ANZICS CTG, Level 3, 10 Ievers St, Carlton, VIC 3053, Australia
    N Engl J Med 350:2247-56. 2004
    It remains uncertain whether the choice of resuscitation fluid for patients in intensive care units (ICUs) affects survival...
  10. ncbi Incidence and prognosis of intraabdominal hypertension in a mixed population of critically ill patients: a multiple-center epidemiological study
    Manu L N G Malbrain
    Intensive Care Unit Director, Medical Intensive Care Unit, Ziekenhuis Netwerk Antwerpen, Campus Stuivenberg, Lange Beeldekensstraat 267, B 2060 Antwerpen 6, Belgium
    Crit Care Med 33:315-22. 2005
    ....
  11. ncbi Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study
    Andres Esteban
    Unidad de Cuidados Intensivos, Hospital Universitario de Getafe, Carretera de Toledo Km 12, 5, 28905 Getafe, Madrid, Spain
    JAMA 287:345-55. 2002
    ..The outcome of patients receiving mechanical ventilation for particular indications has been studied, but the outcome in a large number of unselected, heterogeneous patients has not been reported...
  12. ncbi Serial evaluation of the SOFA score to predict outcome in critically ill patients
    F L Ferreira
    Department of Intensive Care, Erasme University Hospital, Route de Lennik, 808, B 1070 Brussels, Belgium
    JAMA 286:1754-8. 2001
    ..Evaluation of trends in organ dysfunction in critically ill patients may help predict outcome...
  13. ncbi International Nosocomial Infection Control Consortium (INICC) report, data summary for 2003-2008, issued June 2009
    Victor D Rosenthal
    International Nosocomial Infection Control Consortium, Buenos Aires, Argentina
    Am J Infect Control 38:95-104.e2. 2010
    ..Infection Control Consortium (INICC) surveillance study from January 2003 through December 2008 in 173 intensive care units (ICUs) in Latin America, Asia, Africa, and Europe...
  14. pmc Correlates of severe disease in patients with 2009 pandemic influenza (H1N1) virus infection
    Ryan Zarychanski
    Department of Internal Medicine, University of Manitoba, CancerCare Manitoba, Winnipeg, Manitoba
    CMAJ 182:257-64. 2010
    ..The objective of this study was to identify factors correlated with severity of disease in confirmed cases of pandemic H1N1 influenza...
  15. ncbi Prevalence of intra-abdominal hypertension in critically ill patients: a multicentre epidemiological study
    Manu L N G Malbrain
    Medical Intensive Care Unit, ACZA Campus Stuivenberg, Lange Beeldekensstraat 267, 2060 Antwerp, Belgium manu malbrain skynet be
    Intensive Care Med 30:822-9. 2004
    ..This study assessed the prevalence of IAH and its risk factors in a mixed population of intensive care patients...
  16. ncbi Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial
    Richard R Riker
    University of Vermont College of Medicine, USA
    JAMA 301:489-99. 2009
    ..Gamma-aminobutyric acid receptor agonist medications are the most commonly used sedatives for intensive care unit (ICU) patients, yet preliminary evidence indicates that the alpha(2) agonist dexmedetomidine may have distinct advantages...
  17. ncbi Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study
    Corinne Alberti
    Department of Biostatistics, Saint Louis Hospital, Paris, France
    Intensive Care Med 28:108-21. 2002
    ..To examine the incidence of infections and to describe them and their outcome in intensive care unit (ICU) patients...
  18. ncbi Early versus late parenteral nutrition in critically ill adults
    Michael P Casaer
    Department of Intensive Care Medicine, University Hospitals of the Catholic University of Leuven, Leuven, Belgium
    N Engl J Med 365:506-17. 2011
    ..Controversy exists about the timing of the initiation of parenteral nutrition in critically ill adults in whom caloric targets cannot be met by enteral nutrition alone...
  19. ncbi Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine
    J L Vincent
    Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
    Crit Care Med 26:1793-800. 1998
    ..To evaluate the use of the Sequential Organ Failure Assessment (SOFA) score in assessing the incidence and severity of organ dysfunction in critically ill patients...
  20. ncbi Epidemiology, management, and risk factors for death of invasive Candida infections in critical care: a multicenter, prospective, observational study in France (2005-2006)
    Olivier Leroy
    Service de Réanimation Médicale et des Maladies Infectieuses, Centre Hospitalier Gustave Dron, Tourcoing, France
    Crit Care Med 37:1612-8. 2009
    To describe the evolving epidemiology, management, and risk factors for death of invasive Candida infections in intensive care units (ICUs).
  21. ncbi Continuous renal replacement therapy: a worldwide practice survey. The beginning and ending supportive therapy for the kidney (B.E.S.T. kidney) investigators
    Shigehiko Uchino
    Jikei University School of Medicine, Intensive Care Unit, Department of Anesthesiology, Tokyo, Japan
    Intensive Care Med 33:1563-70. 2007
    ..Little information is available regarding current practice in continuous renal replacement therapy (CRRT) for the treatment of acute renal failure (ARF) and the possible clinical effect of practice variation...
  22. ncbi Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009
    Seema Jain
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 361:1935-44. 2009
    ..We describe the clinical characteristics of patients who were hospitalized with 2009 H1N1 influenza in the United States from April 2009 to mid-June 2009...
  23. ncbi Current epidemiology of septic shock: the CUB-Réa Network
    Djillali Annane
    Service de Reanimation Medicale, Hopital Raymond Poincare, Faculte de Medecine Paris Ile de France Ouest, Université de Versaille Saint Quentinen Yvelinnes, 104, Boulevard Raymond Poincare, 92380 Garches, France
    Am J Respir Crit Care Med 168:165-72. 2003
    ..The frequency of septic shock is increasing with more multiresistant strains. Its crude mortality rate is decreasing, but patients with septic shock still have a high excess risk of death than critically ill patients who are nonseptic...
  24. ncbi Epidemiology of sepsis in Germany: results from a national prospective multicenter study
    Christoph Engel
    Institute of Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16 18, 04107, Leipzig, Germany
    Intensive Care Med 33:606-18. 2007
    ..To determine the prevalence and mortality of ICU patients with severe sepsis in Germany, with consideration of hospital size...
  25. ncbi The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients
    Curtis N Sessler
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University Health System, Richmond, Virginia 23298, USA
    Am J Respir Crit Care Med 166:1338-44. 2002
    ..Our nurses described RASS as logical, easy to administer, and readily recalled. RASS has high reliability and validity in medical and surgical, ventilated and nonventilated, and sedated and nonsedated adult ICU patients...
  26. pmc Risk of severe outcomes among patients admitted to hospital with pandemic (H1N1) influenza
    Alexia Campbell
    Centre for Immunization and Respiratory Infectious Diseases, Infectious Disease and Emergency Preparedness Branch, Public Health Agency of Canada, Ottawa, Ontario
    CMAJ 182:349-55. 2010
    ....
  27. ncbi Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study
    Mitchell M Levy
    Division of Pulmonary and Critical Care Medicine, Warren Alpert Medical School of Brown University, Providence, RI 02906, USA
    Lancet Infect Dis 12:919-24. 2012
    ..We aimed to use data from the Surviving Sepsis Campaign (SSC) to compare models of care and outcomes for patients with severe sepsis and septic shock in the USA and Europe...
  28. ncbi Veterans Affairs initiative to prevent methicillin-resistant Staphylococcus aureus infections
    Rajiv Jain
    Patient Care Services, Veterans Affairs Central Office, and the VA Pittsburgh Healthcare System, Pittsburgh, USA
    N Engl J Med 364:1419-30. 2011
    ..Health care-associated infections with methicillin-resistant Staphylococcus aureus (MRSA) have been an increasing concern in Veterans Affairs (VA) hospitals...
  29. pmc Management of severe sepsis in patients admitted to Asian intensive care units: prospective cohort study
    Jason Phua
    Division of Respiratory and Critical Care Medicine, Department of Medicine, National University Hospital, National University Health System Tower Block, Level 10, 1E Kent Ridge Road, Singapore 119228
    BMJ 342:d3245. 2011
    To assess the compliance of Asian intensive care units and hospitals to the Surviving Sepsis Campaign's resuscitation and management bundles...
  30. ncbi Sepsis incidence and outcome: contrasting the intensive care unit with the hospital ward
    Andres Esteban
    Intensive Care Unit, Hospital Universitario de Getafe, Madrid, Spain
    Crit Care Med 35:1284-9. 2007
    ..To describe the outcome of patients with sepsis according to location on a ward or in an intensive care unit...
  31. ncbi Impact of the Surviving Sepsis Campaign protocols on hospital length of stay and mortality in septic shock patients: results of a three-year follow-up quasi-experimental study
    Alvaro Castellanos-Ortega
    Intensive Care Medicine Department, Hospital Universitario Marques de Valdecilla, Santander, Spain
    Crit Care Med 38:1036-43. 2010
    ..To describe the effectiveness of the Surviving Sepsis Campaign bundles with regard to both implementation and outcome in patients with septic shock and to determine the contribution of the various elements of the bundles to the outcome...
  32. ncbi Decontamination of the digestive tract and oropharynx in ICU patients
    A M G A de Smet
    Division of Perioperative and Emergency Care, University Medical Center, Utrecht, The Netherlands
    N Engl J Med 360:20-31. 2009
    ....
  33. ncbi Effect of reducing interns' work hours on serious medical errors in intensive care units
    Christopher P Landrigan
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 351:1838-48. 2004
    ..Although sleep deprivation has been shown to impair neurobehavioral performance, few studies have measured its effects on medical errors...
  34. pmc Intervention to reduce transmission of resistant bacteria in intensive care
    W Charles Huskins
    Division of Pediatric Infectious Diseases, Mayo Clinic, Rochester, MN 55905, USA
    N Engl J Med 364:1407-18. 2011
    b>Intensive care units (ICUs) are high-risk settings for the transmission of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE).
  35. pmc Decreasing mortality in severe sepsis and septic shock patients by implementing a sepsis bundle in a hospital setting
    Sandra Christina Pereira Lima Shiramizo
    Critical Care Unit, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
    PLoS ONE 6:e26790. 2011
    ..The Surviving Sepsis Campaign (SSC) guidelines for the management of severe sepsis (SS) and septic shock (SSh) have been recommended to reduce morbidity and mortality...
  36. pmc Screening, isolation, and decolonisation strategies in the control of meticillin resistant Staphylococcus aureus in intensive care units: cost effectiveness evaluation
    Julie V Robotham
    Modelling and Economics, Health Protection Agency, London NW9 5EQ, UK
    BMJ 343:d5694. 2011
    To assess the cost effectiveness of screening, isolation, and decolonisation strategies in the control of meticillin resistant Staphylococcus aureus (MRSA) in intensive care units.
  37. pmc Value of soluble TREM-1, procalcitonin, and C-reactive protein serum levels as biomarkers for detecting bacteremia among sepsis patients with new fever in intensive care units: a prospective cohort study
    Longxiang Su
    Department of Respiratory Medicine, Hainan Branch of Chinese PLA General Hospital, Sanya, Hainan Province 572013, China
    BMC Infect Dis 12:157. 2012
    ....
  38. ncbi Effect of daily chlorhexidine bathing on hospital-acquired infection
    Michael W Climo
    Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, VA 23249, USA
    N Engl J Med 368:533-42. 2013
    ..Results of previous single-center, observational studies suggest that daily bathing of patients with chlorhexidine may prevent hospital-acquired bloodstream infections and the acquisition of multidrug-resistant organisms (MDROs)...
  39. pmc Brazilian Sepsis Epidemiological Study (BASES study)
    Eliezer Silva
    Intensive Care Unit, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
    Crit Care 8:R251-60. 2004
    Consistent data about the incidence and outcome of sepsis in Latin American intensive care units (ICUs), including Brazil, are lacking. This study was designed to verify the actual incidence density and outcome of sepsis in Brazilian ICUs...
  40. ncbi Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders' conference
    Dale M Needham
    OACIS Group, Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
    Crit Care Med 40:502-9. 2012
    Millions of patients are discharged from intensive care units annually...
  41. ncbi Epidemiology of invasive candidiasis
    Maiken C Arendrup
    Department of Microbiological Surveillance and Research, Division of Microbiology and Diagnostics, Statens Serum Institute, Copenhagen, Denmark
    Curr Opin Crit Care 16:445-52. 2010
    ..This review covers candidaemia in numbers, susceptibility issues, host groups, risk factors and outcome...
  42. ncbi Procalcitonin-guided algorithms of antibiotic therapy in the intensive care unit: a systematic review and meta-analysis of randomized controlled trials
    Petros Kopterides
    Second Critical Care Department, Attiko University Hospital, University of Athens Medical School, Athens, Greece
    Crit Care Med 38:2229-41. 2010
    ..We sought to determine the effectiveness and safety of procalcitonin-guided algorithms in the management of septic patients in the intensive care unit...
  43. ncbi Antimicrobial susceptibility among gram-negative isolates collected from intensive care units in North America, Europe, the Asia-Pacific Rim, Latin America, the Middle East, and Africa between 2004 and 2009 as part of the Tigecycline Evaluation and Survei
    Xavier Bertrand
    Centre Hospitalier Universitaire Besançon, Besancon, France
    Clin Ther 34:124-37. 2012
    ..The Tigecycline Evaluation and Surveillance Trial is an antimicrobial susceptibility surveillance program that collects gram-positive and gram-negative organisms globally...
  44. ncbi Clinical outcomes of health-care-associated infections and antimicrobial resistance in patients admitted to European intensive-care units: a cohort study
    Marie Laurence Lambert
    Public Health and Surveillance Department, Scientific Institute for Public Health, Brussels, Belgium
    Lancet Infect Dis 11:30-8. 2011
    ..We aimed to assess excess mortality and length of stay in intensive-care units from bloodstream infections and pneumonia...
  45. ncbi A multifaceted intervention for quality improvement in a network of intensive care units: a cluster randomized trial
    Damon C Scales
    Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada
    JAMA 305:363-72. 2011
    ..Evidence-based practices improve intensive care unit (ICU) outcomes, but eligible patients may not receive them. Community hospitals treat most critically ill patients but may have few resources dedicated to quality improvement...
  46. pmc Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    JAMA 306:1574-81. 2011
    ....
  47. ncbi Effect of acute renal failure requiring renal replacement therapy on outcome in critically ill patients
    Philipp G H Metnitz
    Department of Reanimation Medicale, Hopital St Louis, University Lariboisière St Louis, Paris, France
    Crit Care Med 30:2051-8. 2002
    ..The aim of this study was to analyze severity of illness and mortality in a group of critically ill patients with acute renal failure requiring renal replacement therapy in a number of Austrian intensive care units.
  48. pmc Prognosis for long-term survival and renal recovery in critically ill patients with severe acute renal failure: a population-based study
    Sean M Bagshaw
    Department of Critical Care Medicine, Calgary Health Region, University of Calgary, Calgary, Alberta, Canada
    Crit Care 9:R700-9. 2005
    ..Severe acute renal failure (sARF) is associated with considerable morbidity, mortality and use of healthcare resources; however, its precise epidemiology and long-term outcomes have not been well described in a non-specified population...
  49. ncbi ViEWS--Towards a national early warning score for detecting adult inpatient deterioration
    David R Prytherch
    Portsmouth Hospitals NHS Trust, United Kingdom
    Resuscitation 81:932-7. 2010
    ..To develop a validated, paper-based, aggregate weighted track and trigger system (AWTTS) that could serve as a template for a national early warning score (EWS) for the detection of patient deterioration...
  50. pmc Nonrecovery of kidney function and death after acute on chronic renal failure
    Chi yuan Hsu
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    Clin J Am Soc Nephrol 4:891-8. 2009
    ..Relatively little is known about clinical outcomes, especially long-term outcomes, among patients who have chronic kidney disease (CKD) and experience superimposed acute renal failure (ARF; acute on chronic renal failure)...
  51. ncbi Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study
    Daniel H Kett
    Department of Medicine, Division of Pulmonary and Critical Care, The University of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, FL, USA
    Crit Care Med 39:665-70. 2011
    ..To provide a global, up-to-date picture of the prevalence, treatment, and outcomes of Candida bloodstream infections in intensive care unit patients and compare Candida with bacterial bloodstream infection...
  52. ncbi Reduced mortality after the implementation of a protocol for the early detection of severe sepsis
    Glauco A Westphal
    Hospital Municipal São José, Joinville, Brazil 89202 000
    J Crit Care 26:76-81. 2011
    ..We evaluate the impact that implementing an in-hospital protocol for the early detection of sepsis risk has on mortality from severe sepsis/septic shock...
  53. ncbi Procalcitonin algorithms for antibiotic therapy decisions: a systematic review of randomized controlled trials and recommendations for clinical algorithms
    Philipp Schuetz
    Department of Emergency Medicine, Harvard School of Public Health, Boston, MA 02115, USA
    Arch Intern Med 171:1322-31. 2011
    ..We propose specific procalcitonin algorithms for low-, moderate-, and high-acuity patients as a basis for future trials aiming at reducing antibiotic overconsumption...
  54. ncbi Changes in the epidemiology of methicillin-resistant Staphylococcus aureus in intensive care units in US hospitals, 1992-2003
    R Monina Klevens
    Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 42:389-91. 2006
    ..9% in 1992 to 64.4% in 2003 for hospitals in the National Nosocomial Infections Surveillance system. During the same period, there was a decrease in resistance rates for several non- beta -lactam drugs among the MRSA isolates...
  55. ncbi Different assessment tools for intensive care unit delirium: which score to use?
    Alawi Luetz
    Department of Anesthesiology and Intensive Care Medicine, Campus Virchow Klinikum, Charite Universitaetsmedizin Berlin, Berlin, Germany
    Crit Care Med 38:409-18. 2010
    ..Currently, there are several assessment tools available for detection of delirium, but only a few of these assessment systems are developed specifically to screen for delirium in ICU patients...
  56. pmc Delirium as a predictor of long-term cognitive impairment in survivors of critical illness
    Timothy D Girard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, and Department of Medicine, Saint Thomas Hospital, Nashville, TN, USA
    Crit Care Med 38:1513-20. 2010
    ..To test the hypothesis that duration of delirium in the intensive care unit is an independent predictor of long-term cognitive impairment after critical illness requiring mechanical ventilation...
  57. ncbi Active cytomegalovirus infection is common in mechanically ventilated medical intensive care unit patients
    Laurent Chiche
    Service de Reanimation Medicale, Hopital Sainte Marguerite, URMITE UMR CNRS 6236, Universite de la Mediterranee, Marseille, France
    Crit Care Med 37:1850-7. 2009
    ..To assess the incidence, risk factors, and outcome of active cytomegalovirus (CMV) infection in nonimmunosuppressed intensive care unit (ICU) patients...
  58. ncbi The impact of delirium in the intensive care unit on hospital length of stay
    E W Ely
    Departments of Internal Medicine, Divisions of General Internal Medicine and Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
    Intensive Care Med 27:1892-900. 2001
    ..To determine the relationship between delirium in the intensive care unit (ICU) and outcomes including length of stay in the hospital...
  59. ncbi The epidemiology of the systemic inflammatory response
    C Brun-Buisson
    Service de Réanimation Médicale and Unité d Hygiène et Prévention de L Infection, Hopital Henri Mondor, Assistance Publique Hôpitaux de Paris and Université Paris 12, Creteil, France
    Intensive Care Med 26:S64-74. 2000
    ....
  60. ncbi Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: a randomized trial
    Jens U Jensen
    Copenhagen HIV Programme, University of Copenhagen, Copenhagen, Denmark
    Crit Care Med 39:2048-58. 2011
    For patients in intensive care units, sepsis is a common and potentially deadly complication and prompt initiation of appropriate antimicrobial therapy improves prognosis...
  61. ncbi Epidemiology of sepsis syndrome in 8 academic medical centers
    K E Sands
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    JAMA 278:234-40. 1997
    ..Sepsis syndrome is a leading cause of mortality in hospitalized patients. However, few studies have described the epidemiology of sepsis syndrome in a hospitalwide population...
  62. ncbi Risk factors for the transmission of methicillin-resistant Staphylococcus aureus in an adult intensive care unit: fitting a model to the data
    Hajo Grundmann
    Division of Microbiology and Infectious Diseases, University Hospital Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    J Infect Dis 185:481-8. 2002
    ..when methicillin-resistant Staphylococcus aureus (MRSA) infection occurs at highly endemic levels in intensive care units. A cohort study was done to identify exposures associated with cases that likely were the result of cross-..
  63. ncbi Universal surveillance for methicillin-resistant Staphylococcus aureus in 3 affiliated hospitals
    Ari Robicsek
    Evanston Northwestern Healthcare and Northwestern University Feinberg School of Medicine, Evanston, Illinois 60201, USA
    Ann Intern Med 148:409-18. 2008
    ..The effect of large-scale expanded surveillance for methicillin-resistant Staphylococcus aureus (MRSA) on health care-associated MRSA disease is not known...
  64. ncbi Guidelines for evaluation of new fever in critically ill adult patients: 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of America
    NAOMI P O'GRADY
    National Institutes of Health, Bethesda, MD, USA
    Crit Care Med 36:1330-49. 2008
    ..To update the practice parameters for the evaluation of adult patients who develop a new fever in the intensive care unit, for the purpose of guiding clinical practice...
  65. ncbi Eliminating catheter-related bloodstream infections in the intensive care unit
    Sean M Berenholtz
    Departments of Anesthesiology CCM and Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Crit Care Med 32:2014-20. 2004
    ..To determine whether a multifaceted systems intervention would eliminate catheter-related bloodstream infections (CR-BSIs)...
  66. ncbi Risk factors and outcome of transfusion-related acute lung injury in the critically ill: a nested case-control study
    Alexander P J Vlaar
    Intensive Care Department, Academic Medical Center, Amsterdam, The Netherlands
    Crit Care Med 38:771-8. 2010
    ..To determine the incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of critically ill patients...
  67. pmc Assessing the role of undetected colonization and isolation precautions in reducing methicillin-resistant Staphylococcus aureus transmission in intensive care units
    Theodore Kypraios
    School of Mathematical Sciences, University of Nottingham, Nottingham, UK
    BMC Infect Dis 10:29. 2010
    ..Recent methodological developments have made it possible to estimate these quantities using routine surveillance data...
  68. pmc Evaluation of SOFA-based models for predicting mortality in the ICU: A systematic review
    Lilian Minne
    Department of Medical Informatics, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Crit Care 12:R161. 2008
    ..To systematically review studies evaluating the performance of Sequential Organ Failure Assessment (SOFA)-based models for predicting mortality in patients in the intensive care unit (ICU)...
  69. ncbi Compliance with antiseptic hand rub use in intensive care units: the Hawthorne effect
    Tim Eckmanns
    Institute of Hygiene and Environmental Medicine, Charite University Medicine Berlin, Berlin, Germany
    Infect Control Hosp Epidemiol 27:931-4. 2006
    ..To determine the influence the Hawthorne effect has on compliance with antiseptic hand rub (AHR) use among healthcare personnel...
  70. pmc Sedation practice in the intensive care unit: a UK national survey
    Henrik Reschreiter
    Royal Adelaide Hospital, North Terrace, Adelaide, SA 5000, Australia
    Crit Care 12:R152. 2008
    The purpose of this study was to evaluate sedation practice in UK intensive care units (ICUs), particularly the implementation of daily sedation holding, written sedation guidelines, sedation scoring tools and choice of agents.
  71. ncbi Promoting Global Research Excellence in Severe Sepsis (PROGRESS): lessons from an international sepsis registry
    R Beale
    Adult Intensive Care Unit, Guy s and St Thomas NHS Foundation Trust, St Thomas Hospital, Lambeth Palace Road, SE1 7EH, London, UK
    Infection 37:222-32. 2009
    ....
  72. ncbi Severe bloodstream infections: a population-based assessment
    Kevin B Laupland
    Department of Critical Care Medicine, University of Calgary, Calgary Health Region, and Calgary Laboratory Services, Calgary, Alberta, Canada
    Crit Care Med 32:992-7. 2004
    ..We sought to define the incidence and microbiology of severe bloodstream infection (bloodstream infection associated with intensive care unit admission within 48 hrs) and assess risk factors for acquisition and death...
  73. ncbi External validation of Acute Physiology and Chronic Health Evaluation IV in Dutch intensive care units and comparison with Acute Physiology and Chronic Health Evaluation II and Simplified Acute Physiology Score II
    Sylvia Brinkman
    Department of Medical Informatics, Academic Medical Center, University of Amsterdam, Amsterdam, 1100 DE, The Netherlands
    J Crit Care 26:105.e11-8. 2011
    ....
  74. pmc Central line bundle implementation in US intensive care units and impact on bloodstream infections
    E Yoko Furuya
    Division of Infectious Diseases, Columbia University College of Physicians and Surgeons, New York, New York, United States of America
    PLoS ONE 6:e15452. 2011
    ..We examine the extent of adoption of Central Line (CL) Bundle elements throughout US intensive care units (ICU) and determine their effectiveness in preventing CLABSIs.
  75. ncbi Discrepant attitudes about teamwork among critical care nurses and physicians
    Eric J Thomas
    University of Texas Houston Medical School, Department of Medicine, Division of General Internal Medicine, USA
    Crit Care Med 31:956-9. 2003
    ..To measure and compare critical care physicians' and nurses' attitudes about teamwork...
  76. ncbi The respiratory variation in inferior vena cava diameter as a guide to fluid therapy
    Marc Feissel
    Réanimation Médicale et Maladies Infectieuses, Centre Hospitalier de Belfort, Belfort, France
    Intensive Care Med 30:1834-7. 2004
    ..To investigate whether the respiratory variation in inferior vena cava diameter (DeltaD(IVC)) could be related to fluid responsiveness in mechanically ventilated patients...
  77. pmc Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital
    Jia Chang Cai
    2nd Affiliated Hospital of Zhejiang University, 88 Jiefang Rd, Hangzhou, China 310009
    Antimicrob Agents Chemother 52:2014-8. 2008
    ..coli isolate with carbapenem resistance or reduced carbapenem susceptibility were recovered from intensive care units (ICUs) in our hospital...
  78. ncbi Isolation of patients in single rooms or cohorts to reduce spread of MRSA in intensive-care units: prospective two-centre study
    Jorge A Cepeda
    Department of Clinical Microbiology, University College London Hospitals, London W1T 4 JF, UK
    Lancet 365:295-304. 2005
    ..We aimed to assess the effectiveness of moving versus not moving infected or colonised patients in intensive-care units to prevent transmission of MRSA...
  79. ncbi Severe maternal morbidity during pregnancy, delivery and puerperium in the Netherlands: a nationwide population-based study of 371,000 pregnancies
    J J Zwart
    Department of Obstetrics, Leiden University Medical Centre, Leiden, The Netherlands
    BJOG 115:842-50. 2008
    ..To assess incidence, case fatality rate, risk factors and substandard care in severe maternal morbidity in the Netherlands...
  80. ncbi Acute renal failure in patients with sepsis in a surgical ICU: predictive factors, incidence, comorbidity, and outcome
    Eric A J Hoste
    Intensive Care Unit and Renal Unit, Ghent University Hospital, Gent, Belgium
    J Am Soc Nephrol 14:1022-30. 2003
    ..This model allows initiating specific therapeutic measures earlier in the course of sepsis, hopefully resulting in a lower incidence of ARF and needi for RRT, thereby lowering mortality...
  81. pmc Case fatality rates based on population estimates of influenza-like illness due to novel H1N1 influenza: New York City, May-June 2009
    James L Hadler
    Department of Health and Mental Hygiene, City of New York, New York, New York, United States of America
    PLoS ONE 5:e11677. 2010
    ..New York City (NYC) experienced an intensive initial outbreak that peaked in late May, providing the need and opportunity to rapidly quantify the severity of nH1N1...
  82. pmc Regulation and prognostic relevance of serum ghrelin concentrations in critical illness and sepsis
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 14:R94. 2010
    ....
  83. ncbi Incidence of adverse drug events and medication errors in intensive care units: a prospective multicenter study
    Raja R Benkirane
    Moroccan Pharmacovigilance Centre, Rabat, Marocco
    J Patient Saf 5:16-22. 2009
    ....
  84. pmc Clinical review: scoring systems in the critically ill
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, Brussels, Belgium
    Crit Care 14:207. 2010
    ..All these scoring systems will need to be updated with time as ICU populations change and new diagnostic, therapeutic and prognostic techniques become available...
  85. ncbi Incidence and outcomes of acute kidney injury in intensive care units: a Veterans Administration study
    Charuhas V Thakar
    Nephrology, Cincinnati VA Medical Center, Cincinnati, OH, USA
    Crit Care Med 37:2552-8. 2009
    ..Acute kidney injury in intensive care unit patients is associated with significant mortality...
  86. ncbi Patients readmitted to ICUs* : a systematic review of risk factors and outcomes
    A L Rosenberg
    Department of Anesthesiology and Critical Care, University of Michigan Medical Center, Ann Arbor 48109, USA
    Chest 118:492-502. 2000
    ..To evaluate the causes, risk factors, and mortality rates associated with unexpected readmission to medical and surgical ICUs...
  87. pmc Resuscitation fluid use in critically ill adults: an international cross-sectional study in 391 intensive care units
    Simon Finfer
    Critical Care and Trauma Division, The George Institute for International Health, PO Box M201, Missenden Road, NSW 2050, Australia
    Crit Care 14:R185. 2010
    ..Recent evidence suggests that choice of fluid used for resuscitation may influence mortality in critically ill patients...
  88. ncbi Premedication for tracheal intubation: a prospective survey in 75 neonatal and pediatric intensive care units
    Lionel Simon
    Réanimation Chirurgicale, Hopital Cochin Saint Vincent de Paul, Universite Paris V, Paris, France
    Crit Care Med 32:565-8. 2004
    ..Our objective was to investigate the practice of premedication before tracheal intubation in neonatal and pediatric units and determine the influence of premedication on intubating conditions...
  89. ncbi Hospitalized community-acquired pneumonia in the elderly: age- and sex-related patterns of care and outcome in the United States
    Vladimir Kaplan
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Respir Crit Care Med 165:766-72. 2002
    ..1 billion was incurred by cases managed in intensive care units. We conclude that in the hospitalized elderly, CAP is a common and frequently fatal disease that often ..
  90. ncbi Clinical practice and risk factors for immediate complications of endotracheal intubation in the intensive care unit: a prospective, multiple-center study
    Samir Jaber
    Intensive Care Unit, Department of Anesthesiology B, DAR B CHU de Montpellier, Hopital Saint Eloi, Universite Montpellier 1, France
    Crit Care Med 34:2355-61. 2006
    ..To describe the current practice of physicians, to report complications associated with endotracheal intubation (ETI) performed in THE intensive care unit (ICU), and to isolate predictive factors of immediate life-threatening complications...
  91. pmc Readmission to a surgical intensive care unit: incidence, outcome and risk factors
    Axel Kaben
    Department of Anesthesiology and Intensive Care, Friedrich Schiller University Hospital, Erlanger Allee 101, Jena, 07743, Germany
    Crit Care 12:R123. 2008
    ..We investigated the incidence of, outcome from and possible risk factors for readmission to the surgical intensive care unit (ICU) at Friedrich Schiller University Hospital, Jena, Germany...
  92. ncbi Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial
    Tim C Jansen
    Department of Intensive Care, Erasmus MC University Medical Centre, Rotterdam, The Netherlands
    Am J Respir Crit Care Med 182:752-61. 2010
    ..It is unknown whether lactate monitoring aimed to decrease levels during initial treatment in critically ill patients improves outcome...
  93. ncbi Patients' recollections of stressful experiences while receiving prolonged mechanical ventilation in an intensive care unit
    Armando J Rotondi
    University of Pittsburgh, Pittsburgh, PA
    Crit Care Med 30:746-52. 2002
    ..To describe stressful experiences of adult patients who received mechanical ventilation for > or =48 hrs in an intensive care unit...
  94. ncbi Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China
    Baoli Cheng
    Department of Anesthesiology, Intensive Care Unit, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    Crit Care Med 35:2538-46. 2007
    To determine the occurrence rate, outcomes, and the characteristics of severe sepsis in surgical intensive care units in multiple medical centers within China and to assess the cost and resource use of severe sepsis in China.
  95. ncbi Invasive aspergillosis in critically ill patients without malignancy
    Wouter Meersseman
    Medical Intensive Care Unit, Department of General Internal Medicine, University Hospital, Leuven, Belgium
    Am J Respir Crit Care Med 170:621-5. 2004
    ..IA is an emerging and devastating infectious disease in patients in the ICU without malignancy. In those patients, host criteria for probable fungal infections should probably be adapted...
  96. ncbi C-reactive protein and procalcitonin as predictors of survival and septic shock in ventilator-associated pneumonia
    G Hillas
    Dept of Respiratory and Critical Care Medicine, SOTIRIA Chest Diseases Hospital, Athens, Greece
    Eur Respir J 35:805-11. 2010
    ..The only factor predicting the development of septic shock was SOFA on D1 (OR 7.44, 95% CI 1.330-5.715). Neither PCT and CRP threshold values nor their kinetics can predict VAP survival or septic shock development...
  97. ncbi Permissive underfeeding and intensive insulin therapy in critically ill patients: a randomized controlled trial
    Yaseen M Arabi
    Department of Intensive Care Medicine, King Abdulaziz Medical City, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
    Am J Clin Nutr 93:569-77. 2011
    ..Nutritional support has been recognized as an essential part of intensive care unit management. However, the appropriate caloric intake for critically ill patients remains ill defined...
  98. pmc Circulating soluble urokinase plasminogen activator receptor is stably elevated during the first week of treatment in the intensive care unit and predicts mortality in critically ill patients
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 15:R63. 2011
    ....
  99. ncbi An algorithm to estimate the importance of bacterial acquisition routes in hospital settings
    M C J Bootsma
    Department of Mathematics, Utrecht University, Utrecht, Kingdom of the Netherlands
    Am J Epidemiol 166:841-51. 2007
    ..of third-generation cephalosporin-resistant Enterobacteriaceae (CRE) from September 2001 to May 2002 in two intensive care units (ICUs) (n = 277 and n = 180, respectively) of Utrecht, Kingdom of the Netherlands...
  100. ncbi Hemodynamic monitoring in shock and implications for management. International Consensus Conference, Paris, France, 27-28 April 2006
    Massimo Antonelli
    Istituto di Anestesiologia e Rianimazione, Policlinico Universitario A Gemelli, Universita Cattolica del Sacro Cuore, Largo A Gemelli, 8, 00168 Rome, Italy
    Intensive Care Med 33:575-90. 2007
    ..The goal of this consensus statement is to provide recommendations regarding the monitoring and management of the critically ill patient with shock...
  101. pmc Cytomegalovirus reactivation in critically ill immunocompetent patients
    Ajit P Limaye
    Department of Laboratory Medicine, University of Washington Medical Center, 1959 NE Pacific St, Seattle, WA 98195 7110, USA
    JAMA 300:413-22. 2008
    ....

Research Grants72

  1. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    T O SHEA; Fiscal Year: 2005
    ..in this region there are approximately 20,000 births, including 1400 who are admitted to the WFUSM neonatal intensive care units, and 270 who are very low birth weight...
  2. Effects of Noise on Newborns < 1000g Birthweight
    Robert Lasky; Fiscal Year: 2007
    Noise levels in neonatal intensive care units (NICUs) may have serious adverse effects on high risk infants by increasing apneic, bradycardic, or desaturation episodes; sleep disturbances; mechanical ventilation; hospital stay; poor ..
  3. Hybrid Optical/Doppler Imaging of Ischemia in NEC - a multicenter trial
    David A Benaron; Fiscal Year: 2010
    ..It is the most common surgical emergency involving neonates admitted to Newborn Intensive Care Units. Currently, clinicians are unable to identify which infants will go on to develop NEC before they become ..
  4. Alpha B crystallin as a novel therapeutic for SIRS and Sepsis
    Jonathan B Rothbard; Fiscal Year: 2011
    ..the host response to a bacterial infection or severe trauma, is responsible for over half of the deaths in intensive care units accounting for more than 200,000 deaths per year...
  5. Mitochondrial dysfunction, oxidative stress, and surgical acute kidney injury
    FREDERIC TREMAINE BILLINGS; Fiscal Year: 2013
    ..Studies will be performed in Vanderbilt University Medical Center operating rooms, intensive care units, and clinics, and in Division of Clinical Pharmacology laboratories...
  6. Wireless At-Risk Infant Monitoring System
    JASON HOLMSTEDT; Fiscal Year: 2012
    ..g., sudden infant death syndrome). While neonatology and neonatal intensive care units (NICUs) have greatly raised the survival rate of at-risk, very low birth weight, and extremely premature ..
  7. Novel Therapeutic Targets in Necrotizing Enterocolitis
    Peter J Giannone; Fiscal Year: 2012
    Necrotizing enterocolitis (NEC), a major cause of morbidity and mortality in neonatal intensive care units, is a disease for which there is currently no medical treatment. Treatment of infants that develop NEC is solely supportive...
  8. Biomarker Profiles for Early Diagnosis of Sepsis in Neonates
    JAMES PRESTON MAPES; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Sepsis is a frequent and serious problem in neonatal intensive care units, particularly in very low birth weight (VLBW) infants...
  9. Exploiting deep ocean biology for biomedical discovery
    David C Rowley; Fiscal Year: 2011
    ..For example, more than 60% of staph infections in intensive care units are resistant to at least one medicine commonly used to treat these infections...
  10. Advancing a Lead Candidate Hantavirus Pulmonary Syndrome DNA Vaccine
    JAY WILLIAMS HOOPER; Fiscal Year: 2013
    ..HPS is highly pathogenic in men and women of any age with a case-fatality rate of 30-40% even in modern intensive care units. Progression of the disease from first symptoms to respiratory distress and shock can be rapid...
  11. Molecular mechanism of apolipoprotein binding to lipopolysaccharides
    PAUL MICHIEL WEERS; Fiscal Year: 2013
    ..When released in the circulation, LPS cause septic shock, a major cause of death in intensive care units. In the current proposal we aim to provide a molecular basis for the apolipoprotein-LPS interaction...
  12. Plasma iNOS IVD Prognosticates Sepsis Prior to Organ Damage and Dysfunction
    Robert J Webber; Fiscal Year: 2010
    ..development project are [1] to conduct a clinical study on 560 subjects, 360 trauma patients admitted to intensive care units (ICUs) at three regional trauma centers and 200 exempt "unlinked, diagnostic specimens" from normal healthy ..
  13. Role of phosphatidylethanolamine in regulating virulence in Candida albicans
    SARAH ELIZABETH DAVIS; Fiscal Year: 2013
    ..Candida are also the fourth most common cause of systemic infections (~30% mortality rate) in intensive care units This fellowship proposal explores the hypothesis that the phospholipids phosphatidylethanolamine (PE) and ..
  14. Molecular Basis for Priming of the Neutrophil NADPH Oxidase in Trauma and Sepsis
    ALBERT T HSU; Fiscal Year: 2010
    The leading cause of morbidity in Surgical Intensive Care Units in the U.S. is acute lung injury and respiratory failure due to sepsis and trauma, leading to multi-organ system failure (MOSF) and death...
  15. HALF-PINT: Heart and Lung Failure - Pediatric INsulin Titration trial - CCC
    Vinay M Nadkarni; Fiscal Year: 2013
    ..Heart and lung failure are the most common causes of death in critically ill children in Pediatric Intensive Care Units (PICUs)...
  16. A Novel Therapy for Septic Shock
    Xiaoling Qiang; Fiscal Year: 2011
    ..Septic shock is the leading cause of death in non-cardiac intensive care units. Despite advances in the management of trauma victims, the incidence of sepsis and septic shock has ..
  17. Testing the feasibility of patient-controlled sedation in ventilated ICU patients
    Craig R Weinert; Fiscal Year: 2013
    ..provided by applicant): Mechanical ventilation (MV) is the most frequently used life-support modality in intensive care units (ICUs)...
  18. Cooperative Multicenter Maternal Fetal Medicine Units Networks
    John M Thorp; Fiscal Year: 2013
    ..UNC, Wake AHEC/WakeMed, and MAHEC/Mission have state of the art Level III neonatal intensive care units, and Rex has a Level II nursery...
  19. The MIND USA Study
    E Wesley Ely; Fiscal Year: 2012
    ..HEALTH RELEVANCE: Millions of critically ill patients every year develop confusion (delirium) while in Intensive Care Units (ICUs), and though a large portion of these patients go undetected and untreated, ICU teams most often use ..
  20. Confirmatory Screening for Congenital Non-Syndromic Genetic Hearing Loss Using Ta
    Edwin W Naylor; Fiscal Year: 2013
    ..Newborns in the neonatal intensive care units are more likely to suffer from hearing loss as a toxic side effect of the antibiotics which are frequently ..
  21. HALF-PINT: Heart And Lung Failure - Pediatric INsulin Titration trial - DCC
    David Wypij; Fiscal Year: 2013
    ..Heart and lung failure are the most common causes of death in critically ill children in Pediatric Intensive Care Units (PICUs)...
  22. Development of an instrument to track oxygen from blood to mitochondria in vivo
    Kenneth A Schenkman; Fiscal Year: 2013
    ..Our long-term goal is to develop the cell oximeter for clinical use in ambulances, emergency departments, intensive care units, and operating rooms.
  23. Improving Preterm Outcomes by Safeguarding Maternal Mental Health
    Michael Silverstein; Fiscal Year: 2013
    ..R03-funded pilot trial of Problem Solving Education (PSE) among mothers of preterm infants in two neonatal intensive care units (NICUs)...
  24. Regulation and function of Cyr61 in hyperoxia induced acute lung injury
    Yang Jin; Fiscal Year: 2010
    ..syndrome (ARDS) is a devastating syndrome responsible for significant morbidity and mortality in our intensive care units. The pathogenesis of ARDS is still poorly understood and therapeutic options remain limited despite the ..
  25. Collaborative Pediatric Critical Care Research Network At Children's Hospital of
    Joseph A Carcillo; Fiscal Year: 2013
    ..MOF phenotypes and the use of specific therapies have not been systematically investigated in Pediatric Intensive Care Units, other than our own...
  26. Atlas - A Handheld High Resolution Wide-field Retinal Imager
    PAUL ANDREW YATES; Fiscal Year: 2013
    ..in part to the low numbers of pediatric-trained ophthalmologists and ROP diagnostic equipment in neonatal intensive care units (NICUs)...
  27. Mesenteric Lymph Linking Gut & Distant Organ Injury
    Edwin A Deitch; Fiscal Year: 2010
    Trauma is the leading cause of death in people under the age of 40 and MODS is the leading cause of death in intensive care units. Consequently, understanding the mechanisms by which trauma-hemorrhagic shock (T/HS) leads to MODS is of ..
  28. Standardized Rehabilitation for ICU Patients with Acute Respiratory Failure
    Peter E Morris; Fiscal Year: 2013
    ..1 million of the 4.4 million people admitted to US Intensive Care Units (ICU) every year...
  29. Mechanisms of Novel Herbal Therapies for Sepsis.
    Haichao Wang; Fiscal Year: 2013
    ..advance in antibiotic therapy and intensive care, sepsis remains the most common cause of death in the intensive care units, claiming >225,000 victims annually in the U.S. alone...
  30. Gut Circadian Clock and Melatonin Dynamics Following Major Thermal Injury
    Walid M Al Ghoul; Fiscal Year: 2013
    ..of death in the US and the main cause of death among major burn and trauma patients and in non-coronary intensive care units. Numerical estimates of sepsis cost range from 33,865 septicemia-related deaths in the year 2002 in the ..
  31. Adenosine and TLR regulation of costimulatory molecule expression in sepsis
    Catherine Valentine; Fiscal Year: 2013
    ..75% of my time pursuing scientific research, and the remainder as a critical care attending in the intensive care units which will reinforce my focus on studies of sepsis...
  32. A novel therapeutic strategy for Acute Lung Injury: Inhibition of PKC-delta
    JOHN T SWINDLE; Fiscal Year: 2012
    ..by applicant): Sepsis and the related systemic inflammatory response are the leading causes of death in intensive care units. More than 200,000 people die each year in the US from sepsis and associated complications...
  33. CD14: Biosynthesis, Trafficking and Secretion
    DIEGO FERNANDO NINO; Fiscal Year: 2013
    ..1, 2) Therapy for sepsis is mainly supportive and frequently requires admission into intensive care units,(3) with a significant financial burden to the public health system...
  34. PREVENTION OF APOPTOTIC CELL DEATH IN SEPSIS BY BCL-2
    RICHARD SAMUEL HOTCHKISS; Fiscal Year: 2012
    Sepsis is the leading cause of death in most intensive care units with over 210,000 people succumbing to overwhelming infection (or the resultant multiple organ failure) in the United States annually...
  35. Chronic intermittent hyperoxia and development of respiratory control
    Ryan W Bavis; Fiscal Year: 2013
    ..provided by applicant): Supplemental O2 is among the most common treatments employed in neonatal intensive care units, particularly in the care of preterm and very low birth weight infants...
  36. Prevention of Nosocomial Infections and Cost-Effectiveness Refined (P-NICER)
    Patricia W Stone; Fiscal Year: 2012
    ..major contributor to increased morbidity, mortality and hospital costs;and, the majority of these occur in intensive care units (ICUs) and many are associated with insertion of an invasive device...
  37. Temporal analysis of nitric oxide as potential sepsis biomarker
    Mark H Schoenfisch; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Sepsis is the leading cause of death in non-cardiac Intensive Care Units (ICUs) and the 10th leading cause of death in the U.S...
  38. Antagonism of Alpha2A-Adrenoceptor: A Novel Anti-Sepsis Therapy
    Xiaoling Qiang; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Sepsis is one of the leading causes of death in intensive care units. Over 210,000 people succumb to this overwhelming infection in the United States annually...
  39. A novel device for improving sepsis outcomes through hemodynamic optimization
    Brett D Mensh; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Sepsis occurs frequently among critically ill patients hospitalized in intensive care units (ICUs)...
  40. Barrier Dysfunction in Severe Surgical Diseases
    Douglas J Turner; Fiscal Year: 2012
    ..illness, particularly in surgical patients, is very common, and a high percentage of patients in the intensive care units incur stress-related injuries to their very vulnerable GI mucosa, leading to barrier dysfunction...
  41. Modulated Imaging: A Wide-field Optical Imaging Platform for Clinical Research
    Anthony J Durkin; Fiscal Year: 2010
    ..By accurately knowing what areas of tissue are healthy during surgery or in the Intensive Care Units (ICU), doctors may intervene and perform more timely procedures to avoid permanent tissue damage...
  42. Project CLEAR - Changing Lives by Eradicating Antibiotic Resistance
    Susan S Huang; Fiscal Year: 2012
    ..While decolonization has been successful in short-term high risk areas, such as intensive care units, our trial will target the much larger arena of post-discharge infection and re-hospitalization...
  43. Urinary Biomarkers for Recovery After Acute Kidney Injury and Prognosis in Hospit
    ISAAC ELI HALL; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Approximately five percent of all patients and two-thirds of those in intensive care units develop kidney injury at some point during their hospitalization...
  44. Longterm Consequences for Veterans with Sepsis
    Theodore J Iwashyna; Fiscal Year: 2013
    ..life-threatening condition cared for by a wide variety of physicians on both general care floors and in intensive care units throughout the VHA...
  45. The Survival from Acute Myocardial Infarction (SAMI) Initiative
    Henry H Ting; Fiscal Year: 2013
    ..environment in which clinicians are encouraged to solve problems creatively, not cross-training nurses from intensive care units for the cardiac catheterization laboratory, and having physician and nurse champions rather than nurse ..
  46. The Neonatal Microbiome and Necrotizing Enterocolitis
    Phillip I Tarr; Fiscal Year: 2012
    ..These efforts will be accomplished using subjects from three collaborating neonatal intensive care units (NICUs), focusing on the critical, instructive, and understudied pre-NEC stage of illness, and formulating ..
  47. Neonatal EEG Monitor
    Tammy Tsuchida; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Electroencephalography (EEG) is a crucial tool in Neonatal Intensive Care Units (NICU), where it is used to diagnose seizures and status epilepticus and to monitor critically ill neonates...
  48. Accelerating Adoption of Comparative Effectiveness Research in Premature Infants
    Phillip Brian Smith; Fiscal Year: 2010
    ..medical record, along with patient-level data on demographics to identify the worst-performing neonatal intensive care units for each of the AIMs. We will then use specific educational interventions for these poor-performing units...
  49. Mechanisms of age-related inflammatory response in hemorrhagic shock
    Basilia Zingarelli; Fiscal Year: 2011
    ..A common clinical observation in intensive care units is that pediatric patients are less susceptible to develop multiple organ dysfunction syndrome and recover ..
  50. Decreasing Bioburden to Reduce Healthcare-Associated Infections and Readmissions
    Susan S Huang; Fiscal Year: 2013
    ..Studies in intensive care units (ICUs) indicate that decolonization of patients'skin with chlorhexidine, and nares with mupirocin can ..
  51. Suppression of T cell immunity during sepsis
    Thomas S Griffith; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Sepsis is the leading cause of death in most intensive care units, and the death of septic patients usually does not result from the initial septic event but rather from subsequent nosocomial ..
  52. Wireless Novel MicroEEG for Neonatal Apnea and Community Neurological Network
    ZACHARY H IBRAHIM; Fiscal Year: 2013
    ..Despite such obvious need, standard EEG is not constantly available in most Neonatal Intensive Care Units (NICUs)...
  53. Epithelial PLUNC as a determinant of Airway Mucosal Antimicrobial Activity
    YUANPU PETER DI; Fiscal Year: 2012
    ..hospital-acquired infections especially in ventilated patients and are the second most common infection in Intensive Care Units. The conducting airway serves as a first line of defense against bacterial insults through passive action ..
  54. Acute Kidney Failure in a Cancer ICU
    Joshua A Samuels; Fiscal Year: 2010
    ..AKF affects over 50,000 hospitalized Americans each year, and the mortality of patients with AKF in intensive care units has been reported as high as 86%...
  55. Novel Protein Kinase C Targeted Therapy for Acute Lung Injury
    Laurie E Kilpatrick; Fiscal Year: 2013
    ..systemic inflammatory response is a major public health problem and one of the leading causes of death in intensive care units. More than 200,000 people die each year in the US from sepsis and associated complications...
  56. The Impact of Remote ICU Monitoring on Patient Outcomes and Processes of Care
    Peter M Cram; Fiscal Year: 2013
    Background: There is growing appreciation that the staffing of intensive care units (ICUs) by physicians trained in critical care medicine (intensivists) can result in improved patient outcomes...
  57. Cooperative Multicenter Network of Neontal Intensive Care Units
    Seetha Shankaran; Fiscal Year: 2013
    ..The public heath impact will be a reduction of psychosocial and medical costs to families and society. ..
  58. Intrathoracic Pressure Regulation for the Treatment of Septic Shock
    Keith Lurie; Fiscal Year: 2009
    ..the treatment of patients with sepsis, sepsis remains the second most common cause of death in non-coronary intensive care units and the tenth leading cause of death overall in high-income countries...
  59. Age of Blood in Children in Pediatric Intensive Care Units
    Philip C Spinella; Fiscal Year: 2013
    ..The Age of Blood in Children in Pediatric Intensive Care Units (ABC-PICU) trial has been designed to determine if the use of RBCs of short storage duration improves ..
  60. Rapid, sensitive and labor-free immunoassays for sepsis based on magnetic nanoflu
    Hur Koser; Fiscal Year: 2013
    ..Sepsis is the second largest cause of death in non-coronary intensive care units (750,000+ cases, 215,000+ deaths annually in US alone), costing over 17B/year to treat...
  61. ExoU and the Pathogenesis of Pseudomonas Pneumonia
    Alan R Hauser; Fiscal Year: 2012
    ..causes of hospital-acquired pneumonia (HAP), a disease that afflicts 10% of all patients admitted to intensive care units (170)...
  62. p38MAP kinase-dependent mechanisms of fever-enhanced acute lung injury
    Paul S Shapiro; Fiscal Year: 2013
    ..Fever is reported to occur in about half of patients admitted to intensive care units and in up to 90% of those with ALI/ARDS...
  63. Interaction Behaviors Effect on Nursing Care Quality of Older Adults in the ICU
    Marci Lee Nilsen; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Approximately 2.8 million require mechanical ventilation in intensive care units (ICU) in the USA each year and, as a consequence, are unable to communicate using natural speech...
  64. DEVELOPMENT EFFECT ON LOOP DIURETIC OTOTOXICITY
    Leonard Rybak; Fiscal Year: 1999
    Loop diuretics are widely used to treat premature infants in neonatal intensive care units. Recent reports have suggested an increased risk of permanent sensorineural hearing loss among infants receiving such treatments...
  65. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Maragakis; Fiscal Year: 2009
    ..increasingly the cause of a variety of serious infections in hospitalized patients, particularly those in intensive care units. Therapeutic choices for these infections are severely limited since many of these MDR organisms have ..
  66. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Saiman; Fiscal Year: 2009
    ..the 'post-antimicrobial era'has been looming for well over a decade as patients, particularly in intensive care units (ICUs), are increasingly developing infections caused by multidrug-resistant (MDR) pathogens...
  67. Detection of Antibiotic Resistance Genes in Bacterial Agents of Hospital-Acquired
    Andrew Levin; Fiscal Year: 2009
    ..and sepsis are leading causes of morbidity and mortality in critically ill patients, especially in hospital intensive care units. These acute conditions are caused by infection with a range of Gram-positive and Gram-negative bacteria ..
  68. The Effects of Neonatal Intensive Care Deregionalization on Treatment and Infant
    SETH FREEDMAN; Fiscal Year: 2009
    DESCRIPTION (provided by the applicant): Neonatal Intensive Care Units (NICUs) have greatly improved health outcomes for sick, preterm, and underweight infants...
  69. NEOPAIN MULTICENTER TRIAL: DATA COORDINATING CENTER
    Bruce Barton; Fiscal Year: 2001
    ..Analgesic practices recorded prospectively in 109 Neonatal Intensive Care Units (NICUs) showed that opioids and benzodiazepines were most commonly used, with large variations in clinical ..
  70. MICROVASCULAR ABNORMALITIES IN SEPSIS
    Steven Hollenberg; Fiscal Year: 2002
    Septic shock, the leading cause of death in intensive care units, is characterized by vasodilation with decreased peripheral vascular resistance, which is often refractory to exogenously administered vasopressor agents...
  71. DEVELOPING CIRCADIAN RHYTHMICITY
    Scott Rivkees; Fiscal Year: 2002
    ..In neonatal intensive care units, preterm infants are typically exposed to continuous dim lighting without photic time-of-day cues...
  72. Novel Complementary Therapy for Preterm Infants
    John Bauer; Fiscal Year: 2009
    ..these conditions is necrotizing enterocolitis (NEC), a major cause of morbidity and mortality in neonatal intensive care units, is a disease for which there is currently no medical treatment...