intensive care units

Summary

Summary: Hospital units providing continuous surveillance and care to acutely ill patients.

Top Publications

  1. ncbi Critically ill patients readmitted to intensive care units--lessons to learn?
    Philipp G H Metnitz
    Département Réanimation Médicale, Hopital St Louis, Universite Paris VII, Paris, France
    Intensive Care Med 29:241-8. 2003
  2. ncbi Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009
    Seema Jain
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 361:1935-44. 2009
  3. ncbi International study of the prevalence and outcomes of infection in intensive care units
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    JAMA 302:2323-9. 2009
  4. ncbi Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    D C Angus
    Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, and the Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 29:1303-10. 2001
  5. ncbi Risk of severe outcomes among patients admitted to hospital with pandemic (H1N1) influenza
    Alexia Campbell
    Centre for Immunization and Respiratory Infectious Diseases, Infectious Disease and Emergency Preparedness Branch, Public Health Agency of Canada, Ottawa, Ontario
    CMAJ 182:349-55. 2010
  6. ncbi Severe maternal morbidity during pregnancy, delivery and puerperium in the Netherlands: a nationwide population-based study of 371,000 pregnancies
    J J Zwart
    Department of Obstetrics, Leiden University Medical Centre, Leiden, The Netherlands
    BJOG 115:842-50. 2008
  7. ncbi Spectrum of acute renal failure in the intensive care unit: the PICARD experience
    Ravindra L Mehta
    Division of Nephrology, Department of Medicine, University of California San Diego, San Diego, California, USA
    Kidney Int 66:1613-21. 2004
  8. ncbi Active cytomegalovirus infection is common in mechanically ventilated medical intensive care unit patients
    Laurent Chiche
    Service de Reanimation Medicale, Hopital Sainte Marguerite, URMITE UMR CNRS 6236, Universite de la Mediterranee, Marseille, France
    Crit Care Med 37:1850-7. 2009
  9. ncbi Impact of the Surviving Sepsis Campaign protocols on hospital length of stay and mortality in septic shock patients: results of a three-year follow-up quasi-experimental study
    Alvaro Castellanos-Ortega
    Intensive Care Medicine Department, Hospital Universitario Marques de Valdecilla, Santander, Spain
    Crit Care Med 38:1036-43. 2010
  10. ncbi Incidence of adverse drug events and medication errors in intensive care units: a prospective multicenter study
    Raja R Benkirane
    Moroccan Pharmacovigilance Centre, Rabat, Marocco
    J Patient Saf 5:16-22. 2009

Research Grants

  1. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    T O SHEA; Fiscal Year: 2005
  2. Bilirubin-induced Auditory Neuropathy in Preterms
    SANJIV AMIN; Fiscal Year: 2007
  3. Effects of Noise on Newborns < 1000g Birthweight
    Robert Lasky; Fiscal Year: 2007
  4. Biomarker Profiles for Early Diagnosis of Sepsis in Neonates
    James Mapes; Fiscal Year: 2007
  5. Prevention of Nosocomial Infections and Cost-Effectiveness Refined (P-NICER)
    Patricia W Stone; Fiscal Year: 2010
  6. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Maragakis; Fiscal Year: 2009
  7. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Maragakis; Fiscal Year: 2007
  8. AMELIORATION OF SEPSIS BY MACROPHAGE ACTIVATION
    David Williams; Fiscal Year: 1999
  9. Palliation of Thirst in Intensive Care Unit Patients
    Kathleen Puntillo; Fiscal Year: 2009
  10. Mechanisms of Novel Herbal Therapies for Sepsis.
    Haichao Wang; Fiscal Year: 2010

Detail Information

Publications211 found, 100 shown here

  1. ncbi Critically ill patients readmitted to intensive care units--lessons to learn?
    Philipp G H Metnitz
    Département Réanimation Médicale, Hopital St Louis, Universite Paris VII, Paris, France
    Intensive Care Med 29:241-8. 2003
    ..To evaluate risk factors in critically ill patients who were readmitted to an intensive care unit (ICU) during their hospital stay...
  2. ncbi Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009
    Seema Jain
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 361:1935-44. 2009
    ..We describe the clinical characteristics of patients who were hospitalized with 2009 H1N1 influenza in the United States from April 2009 to mid-June 2009...
  3. ncbi International study of the prevalence and outcomes of infection in intensive care units
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    JAMA 302:2323-9. 2009
    Infection is a major cause of morbidity and mortality in intensive care units (ICUs) worldwide. However, relatively little information is available about the global epidemiology of such infections.
  4. ncbi Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    D C Angus
    Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, and the Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 29:1303-10. 2001
    ..To determine the incidence, cost, and outcome of severe sepsis in the United States...
  5. ncbi Risk of severe outcomes among patients admitted to hospital with pandemic (H1N1) influenza
    Alexia Campbell
    Centre for Immunization and Respiratory Infectious Diseases, Infectious Disease and Emergency Preparedness Branch, Public Health Agency of Canada, Ottawa, Ontario
    CMAJ 182:349-55. 2010
    ....
  6. ncbi Severe maternal morbidity during pregnancy, delivery and puerperium in the Netherlands: a nationwide population-based study of 371,000 pregnancies
    J J Zwart
    Department of Obstetrics, Leiden University Medical Centre, Leiden, The Netherlands
    BJOG 115:842-50. 2008
    ..To assess incidence, case fatality rate, risk factors and substandard care in severe maternal morbidity in the Netherlands...
  7. ncbi Spectrum of acute renal failure in the intensive care unit: the PICARD experience
    Ravindra L Mehta
    Division of Nephrology, Department of Medicine, University of California San Diego, San Diego, California, USA
    Kidney Int 66:1613-21. 2004
    ..METHODS: We conducted an observational cohort study of 618 patients with ARF in intensive care units at five academic medical centers in the United States...
  8. ncbi Active cytomegalovirus infection is common in mechanically ventilated medical intensive care unit patients
    Laurent Chiche
    Service de Reanimation Medicale, Hopital Sainte Marguerite, URMITE UMR CNRS 6236, Universite de la Mediterranee, Marseille, France
    Crit Care Med 37:1850-7. 2009
    ..To assess the incidence, risk factors, and outcome of active cytomegalovirus (CMV) infection in nonimmunosuppressed intensive care unit (ICU) patients...
  9. ncbi Impact of the Surviving Sepsis Campaign protocols on hospital length of stay and mortality in septic shock patients: results of a three-year follow-up quasi-experimental study
    Alvaro Castellanos-Ortega
    Intensive Care Medicine Department, Hospital Universitario Marques de Valdecilla, Santander, Spain
    Crit Care Med 38:1036-43. 2010
    ..To describe the effectiveness of the Surviving Sepsis Campaign bundles with regard to both implementation and outcome in patients with septic shock and to determine the contribution of the various elements of the bundles to the outcome...
  10. ncbi Incidence of adverse drug events and medication errors in intensive care units: a prospective multicenter study
    Raja R Benkirane
    Moroccan Pharmacovigilance Centre, Rabat, Marocco
    J Patient Saf 5:16-22. 2009
    ....
  11. ncbi Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome
    Andrew Davies
    FRACP, FJFICM, Intensive Care Unit, Alfred Hospital, Commercial Road, Melbourne, Victoria 3004, Australia
    JAMA 302:1888-95. 2009
    ..It caused an epidemic of critical illness and some patients developed severe acute respiratory distress syndrome (ARDS) and were treated with extracorporeal membrane oxygenation (ECMO)...
  12. ncbi Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival
    Raghavan Murugan
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Kidney Int 77:527-35. 2010
    ..29) was also present in those never admitted to an intensive care unit. Hence acute kidney injury is common even among patients with non-severe pneumonia and is associated with higher immune response and an increased risk of death...
  13. ncbi Compliance with antiseptic hand rub use in intensive care units: the Hawthorne effect
    Tim Eckmanns
    Institute of Hygiene and Environmental Medicine, Charite University Medicine Berlin, Berlin, Germany
    Infect Control Hosp Epidemiol 27:931-4. 2006
    ..To determine the influence the Hawthorne effect has on compliance with antiseptic hand rub (AHR) use among healthcare personnel...
  14. ncbi Psychological distress after severe trauma: a prospective 1-year follow-up study of a trauma intensive care unit population
    Kirsti Tøien
    Intensive Care Unit, Oslo University Hospital, Ulleval, Oslo, Norway
    J Trauma 69:1552-9. 2010
    ..The aim of the study was to investigate the level of psychologic distress after trauma and intensive care unit (ICU) stay, memory from the ICU, and predictors for psychologic distress at 12 months...
  15. ncbi Quality of life in patients aged 80 or over after ICU discharge
    Alexis Tabah
    Medical Surgical ICU, Saint Joseph Hospital Network, 185 rue Raymond Losserand, 75014 Paris, France
    Crit Care 14:R2. 2010
    ..Our objective was to describe self-sufficiency and quality of life one year after intensive care unit (ICU) discharge of patients aged 80 years or over...
  16. ncbi Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients
    M H Kollef
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Chest 115:462-74. 1999
    ..To evaluate the relationship between inadequate antimicrobial treatment of infections (both community-acquired and nosocomial infections) and hospital mortality for patients requiring ICU admission...
  17. ncbi Comparison of two fluid-management strategies in acute lung injury
    Herbert P Wiedemann
    Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, 9500 Euclid Ave, Desk A 90, Cleveland, OH 44195, USA
    N Engl J Med 354:2564-75. 2006
    ..Optimal fluid management in patients with acute lung injury is unknown. Diuresis or fluid restriction may improve lung function but could jeopardize extrapulmonary-organ perfusion...
  18. ncbi Population-based assessment of intensive care unit-acquired bloodstream infections in adults: Incidence, risk factors, and associated mortality rate
    Kevin B Laupland
    Division of Critical Care Medicine, University of Calgary, Calgary Health Region, Alberta, Canada
    Crit Care Med 30:2462-7. 2002
    ..DESIGN: Population-based prospective cohort. SETTING: Multidisciplinary intensive care units. PATIENTS: All Calgary Health Region (population 930,000) adult patients admitted to multidisciplinary ..
  19. ncbi Plasma and urine neutrophil gelatinase-associated lipocalin in septic versus non-septic acute kidney injury in critical illness
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, 3C1 16 Walter C Mackenzie Centre, 8440 122 Street, Edmonton, AB T6G2B7, Canada
    Intensive Care Med 36:452-61. 2010
    ..We sought to determine whether there are unique patterns to plasma and urine neutrophil gelatinase-associated lipocalin (NGAL) in septic compared with non-septic AKI...
  20. ncbi Reduction in mortality associated with statin therapy in patients with severe sepsis
    Paul P Dobesh
    College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska 68198 6045, USA
    Pharmacotherapy 29:621-30. 2009
    ..To evaluate the effect of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) on mortality in patients with severe sepsis...
  21. ncbi Epidemiology and natural history of acute renal failure in the ICU
    Michael Joannidis
    Medical Intensive Care Unit, Department of General Internal Medicine, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Crit Care Clin 21:239-49. 2005
    ....
  22. ncbi SAPS 3 admission score: an external validation in a general intensive care population
    Didier Ledoux
    Soins Intensifs Generaux, Centre Hospitalier Universitaire de Liege, Domaine Universitaire de Sart Tilman Bat B35, 4000 Liege, Belgium
    Intensive Care Med 34:1873-7. 2008
    ..To validate the SAPS 3 admission score in an independent general intensive care case mix and to compare its performances with the APACHE II and the SAPS II scores...
  23. ncbi Clinical characteristics and outcomes of obstetric patients requiring ICU admission
    Daniela N Vasquez
    Intensive Care Unit, Hospital Interzonal General de Agudos Gral, San Martin, 1 y 70, 1900 La Plata, Buenos Aires, Argentina
    Chest 131:718-24. 2007
    ..To review a series of critically ill obstetric patients admitted to our ICU to assess the spectrum of disease, required interventions, and fetal/maternal mortality, and to identify conditions associated with maternal death...
  24. ncbi Recommendations for end-of-life care in the intensive care unit: a consensus statement by the American College [corrected] of Critical Care Medicine
    Robert D Truog
    Harvard Medical School and Children s Hospital, Boston, MA, USA
    Crit Care Med 36:953-63. 2008
    ..S. perspective. They do not use an evidence grading system because most of the recommendations are based on ethical and legal principles that are not derived from empirically based evidence...
  25. ncbi Cytomegalovirus reactivation in critically ill immunocompetent patients
    Ajit P Limaye
    Department of Laboratory Medicine, University of Washington Medical Center, 1959 NE Pacific St, Seattle, WA 98195 7110, USA
    JAMA 300:413-22. 2008
    ....
  26. ncbi Decision-making process, outcome, and 1-year quality of life of octogenarians referred for intensive care unit admission
    Maite Garrouste-Orgeas
    Medical ICU, Saint Joseph Hospital, 185 rue Raymond Losserand, 75014 Paris, France
    Intensive Care Med 32:1045-51. 2006
    ..To describe triage decisions and subsequent outcomes in octogenarians referred to an ICU...
  27. ncbi Procalcitonin kinetics in the prognosis of severe community-acquired pneumonia
    Nicolas Boussekey
    Tourcoing Hospital, Intensive Care and Infectious Disease Unit, 135 rue du Président Coty BP 619, 59208, Tourcoing Cedex, France
    Intensive Care Med 32:469-72. 2006
    ..marker in infectious diseases, but few studies of community-acquired pneumonia (CAP) have been performed in intensive care units (ICU). We analyzed the relationship between PCT kinetics and outcome in ICU patients with severe CAP.
  28. ncbi Nosocomial infections in adult intensive-care units
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennick 808, B 1070, Brussels, Belgium
    Lancet 361:2068-77. 2003
    ..Management of nosocomial infection relies on adequate and appropriate antibiotic therapy, which should be selected after discussion with infectious-disease specialists and adapted as microbiological data become available...
  29. ncbi Is EuroSCORE useful in the prediction of extended intensive care unit stay after cardiac surgery?
    Nouredin Messaoudi
    Department of Cardiac Surgery, Antwerp University Hospital, Edegem, Belgium
    Eur J Cardiothorac Surg 36:35-9. 2009
    ..The aim of this single-center study was to investigate the prediction of extended ICU stay after cardiac surgery using both the additive and logistic model of the European System for Cardiac Operative Risk Evaluation (EuroSCORE)...
  30. ncbi A qualitative exploration of reasons for poor hand hygiene among hospital workers: lack of positive role models and of convincing evidence that hand hygiene prevents cross-infection
    V Erasmus
    Department of Public Health, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Infect Control Hosp Epidemiol 30:415-9. 2009
    ..To study potential determinants of hand hygiene compliance among healthcare workers in the hospital setting...
  31. ncbi The paradox of ventilator-associated pneumonia prevention measures
    Michael Klompas
    Infection Control Department, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Crit Care 13:315. 2009
    ..The paradox makes changes in VAP rates alone an unreliable measure of whether VAP prevention measures are truly beneficial to patients and behooves us to measure their impact on patient outcomes before advocating their adoption...
  32. ncbi Factors associated with maternal death in women admitted to an intensive care unit with severe maternal morbidity
    Antonio F Oliveira Neto
    Department of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    Int J Gynaecol Obstet 105:252-6. 2009
    ..To identify factors associated with maternal death among women with severe maternal morbidity...
  33. ncbi The time-dependent bias and its effect on extra length of stay due to nosocomial infection
    Adrian G Barnett
    Queensland University of Technology, Brisbane, Australia
    Value Health 14:381-6. 2011
    ..This leads to the "time-dependent bias," which biases multiplicative hazard ratios. We demonstrate the time-dependent bias on the additive scale of extra length of stay...
  34. ncbi Prediction models for prolonged intensive care unit stay after cardiac surgery: systematic review and validation study
    Roelof G A Ettema
    University of Applied Science Utrecht, Faculty of Health Care, Bolognalaan 101 3584 CJ Utrecht, Netherlands
    Circulation 122:682-9, 7 p following p 689. 2010
    ..However, no extensive quantitative validation of these models has yet been conducted. This study sought to identify and validate existing prediction models for prolonged ICU length of stay after cardiac surgery...
  35. ncbi Quality of life in the five years after intensive care: a cohort study
    Brian H Cuthbertson
    Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, M4N 3M5, Canada
    Crit Care 14:R6. 2010
    ..Data on quality of life beyond 2 years after intensive care discharge are limited and we aimed to explore this area further. Our objective was to quantify quality of life and health utilities in the 5 years after intensive care discharge...
  36. ncbi Early vs late tracheotomy for prevention of pneumonia in mechanically ventilated adult ICU patients: a randomized controlled trial
    Pier Paolo Terragni
    Anestesia e Rianimazione 1, Ospedale S Giovanni Battista, Universita di Torino, Turin, Italy
    JAMA 303:1483-9. 2010
    ..This is of clinical importance because timing is a key criterion for performing a tracheotomy and patients who receive one require a large amount of health care resources...
  37. ncbi Outcome after injury: memories, health-related quality of life, anxiety, and symptoms of depression after intensive care
    Mona Ringdal
    Institute of Health and Care Sciences, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden
    J Trauma 66:1226-33. 2009
    ....
  38. ncbi Toward shared decision making at the end of life in intensive care units: opportunities for improvement
    Douglas B White
    Division of Pulmonary and Critical Care Medicine and Program in Medical Ethics, Department of Medicine, School of Medicine, University of California, San Francisco, CA 94143 0903, USA
    Arch Intern Med 167:461-7. 2007
    In North America, families generally wish to be involved in end-of-life decisions when the patient cannot participate, yet little is known about the extent to which shared decision making occurs in intensive care units.
  39. ncbi Short-term and long-term mortality in very elderly patients admitted to an intensive care unit
    S E de Rooij
    Department of Internal Medicine, Academic Medical Center, 22700, 1100 DE, Amsterdam, The Netherlands
    Intensive Care Med 32:1039-44. 2006
    ..To report short-term and long-term mortality of very elderly ICU patients and to determine independent risk factors for short-term and long-term mortality..
  40. ncbi Urinary neutrophil gelatinase-associated lipocalin (NGAL) as an early marker of acute kidney injury in critically ill multiple trauma patients
    Konstantinos Makris
    Clinical Biochemistry Department, KAT General Hospital, Kiffissia, Athens, Greece
    Clin Chem Lab Med 47:79-82. 2009
    ..The aim of this study was to evaluate urinary NGAL levels as a predictor of early AKI (first 5 days after injury) in multi-trauma patients...
  41. ncbi Circulating levels of GH predict mortality and complement prognostic scores in critically ill medical patients
    Philipp Schuetz
    Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Internal Medicine, Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
    Eur J Endocrinol 160:157-63. 2009
    ..We assessed the prognostic implications of GH on admission and during follow-up in critically ill adult patients admitted to a medical intensive care unit...
  42. ncbi Oral probiotic and prevention of Pseudomonas aeruginosa infections: a randomized, double-blind, placebo-controlled pilot study in intensive care unit patients
    Christiane Forestier
    Université de Clermont 1 UFR Pharmacie Laboratoire de Bactériologie, 28 place Henri Dunant 63000 Clermont Ferrand France
    Crit Care 12:R69. 2008
    ..tract is an infection control strategy used to reduce the occurrence of ventilator-associated pneumonia in intensive care units. However, antibiotic use in selective decontamination protocols is controversial...
  43. ncbi Mortality in healthy elderly patients after ICU admission
    Emilio Sacanella
    Geriatric Unit, Department of Internal Medicine, Hospital Clinic de Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    Intensive Care Med 35:550-5. 2009
    ..The aim of this study was to assess mortality in healthy elderly patients after non-elective medical ICU admission and to identify predictive factors of mortality in these patients...
  44. ncbi Bench-to-bedside review: rare and common viral infections in the intensive care unit--linking pathophysiology to clinical presentation
    Nicholas Stollenwerk
    Division of Pulmonary and Critical Care Medicine, University of California Davis School of Medicine, Davis, CA, USA
    Crit Care 12:219. 2008
    ..This review discusses the basic pathophysiology leading to clinical presentations in a few common and rare, but important, viruses found in the intensive care unit: influenza, RSV, SARS, VZV, adenovirus, CMV, VHF, and Hantavirus...
  45. ncbi Mini-series: II. clinical aspects. clinically relevant CYP450-mediated drug interactions in the ICU
    Isabel Spriet
    Department of Pharmacy, University Hospital Leuven, Herestraat 49, 3000, Louvain, Belgium
    Intensive Care Med 35:603-12. 2009
    ....
  46. ncbi Quality of life after intensive care: a systematic review of the literature
    Sandra G Oeyen
    Department of Intensive Care Medicine, Ghent University Hospital, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
    Crit Care Med 38:2386-400. 2010
    ....
  47. ncbi Early intervention with erythropoietin does not affect the outcome of acute kidney injury (the EARLYARF trial)
    Zoltan H Endre
    Christchurch Kidney Research Group, Department of Medicine, University of Otago, Christchurch, New Zealand
    Kidney Int 77:1020-30. 2010
    ..with erythropoietin could prevent the development of acute kidney injury in patients in two general intensive care units. As a guide for choosing the patients for treatment we measured urinary levels of two biomarkers, the ..
  48. ncbi C-reactive protein levels and post-ICU mortality in nonsurgical intensive care patients
    Wilhelm Grander
    Department of Intensive Care Medicine, Academic Teaching Hospital Hall in Tirol, Hall in Tirol, Austria
    Chest 138:856-62. 2010
    ..There are no data on the association between acute inflammation during critical illness and long-term mortality in ICU patients...
  49. ncbi Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial
    Pratik P Pandharipande
    Anesthesiology Service, VA TN Valley Health Care System, Nashville, TN 37212 2637, USA
    Crit Care 14:R38. 2010
    ....
  50. ncbi A multifaceted intervention for quality improvement in a network of intensive care units: a cluster randomized trial
    Damon C Scales
    Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada
    JAMA 305:363-72. 2011
    ..Evidence-based practices improve intensive care unit (ICU) outcomes, but eligible patients may not receive them. Community hospitals treat most critically ill patients but may have few resources dedicated to quality improvement...
  51. ncbi Hormonal status and ICU-acquired paresis in critically ill patients
    Tarek Sharshar
    Department of Intensive Care Medicine, AP HP, Raymond Poincare Hospital, University Versailles Saint Quentin en Yvelines, 104 boulevard Raymond Poincaré, 92380, Garches, France
    Intensive Care Med 36:1318-26. 2010
    ..Since ICUAP has been associated with female gender in some studies, we hypothesized that hormonal dysfunction might contribute to ICUAP...
  52. ncbi Regulation and prognostic relevance of serum ghrelin concentrations in critical illness and sepsis
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 14:R94. 2010
    ....
  53. ncbi Therapeutic drug monitoring of beta-lactams in critically ill patients: proof of concept
    Jason A Roberts
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
    Int J Antimicrob Agents 36:332-9. 2010
    ..05) were found to be predictive of mortality. In conclusion, further research is required to determine definitively whether achievement of optimal beta-lactam pharmacodynamic targets improves clinical outcomes...
  54. ncbi One-year trajectories of care and resource utilization for recipients of prolonged mechanical ventilation: a cohort study
    Mark Unroe
    Duke University, Durham, North Carolina 27710, USA
    Ann Intern Med 153:167-75. 2010
    ..Little is known about the patterns of care as patients transition from acute care hospitals to postacute care facilities or about the associated resource utilization...
  55. ncbi Case fatality rates based on population estimates of influenza-like illness due to novel H1N1 influenza: New York City, May-June 2009
    James L Hadler
    Department of Health and Mental Hygiene, City of New York, New York, New York, United States of America
    PLoS ONE 5:e11677. 2010
    ..New York City (NYC) experienced an intensive initial outbreak that peaked in late May, providing the need and opportunity to rapidly quantify the severity of nH1N1...
  56. ncbi Nasal meticillin-resistant Staphylococcus aureus carriage among intensive care unit hospitalised adult patients in a Taiwanese medical centre: one time-point prevalence, molecular characteristics and risk factors for carriage
    C B Chen
    College of Medicine, Chang Gung University, Taoyuan, Taiwan
    J Hosp Infect 74:238-44. 2010
    ..Though most isolates were HA-MRSA, community strains accounted for a proportion of the isolates...
  57. ncbi Posttraumatic stress, anxiety and depression symptoms in patients during the first year post intensive care unit discharge
    Hilde Myhren
    Intensive Care Unit, Ulleval, Oslo University Hospital, Kirkeveien 177, 0407 Oslo, Norway
    Crit Care 14:R14. 2010
    ..To study the level and predictors of posttraumatic stress, anxiety and depression symptoms in medical, surgical and trauma patients during the first year post intensive care unit (ICU) discharge...
  58. ncbi Acute renal failure in patients with sepsis in a surgical ICU: predictive factors, incidence, comorbidity, and outcome
    Eric A J Hoste
    Intensive Care Unit and Renal Unit, Ghent University Hospital, Gent, Belgium
    J Am Soc Nephrol 14:1022-30. 2003
    ..This model allows initiating specific therapeutic measures earlier in the course of sepsis, hopefully resulting in a lower incidence of ARF and needi for RRT, thereby lowering mortality...
  59. ncbi Veterans Affairs initiative to prevent methicillin-resistant Staphylococcus aureus infections
    Rajiv Jain
    Patient Care Services, Veterans Affairs Central Office, and the VA Pittsburgh Healthcare System, Pittsburgh, USA
    N Engl J Med 364:1419-30. 2011
    ..Health care-associated infections with methicillin-resistant Staphylococcus aureus (MRSA) have been an increasing concern in Veterans Affairs (VA) hospitals...
  60. ncbi The impact of a Critical Care Information System (CCIS) on time spent charting and in direct patient care by staff in the ICU: a review of the literature
    Rebecca L Mador
    University of Alberta, Faculty of Medicine and Dentistry, Department of Medicine, Edmonton, AB, Canada
    Int J Med Inform 78:435-45. 2009
    ..The objective of this literature review is to establish the impact of a CCIS on time spent documenting and in direct patient care by staff in the ICU...
  61. ncbi Incidence and outcomes of acute kidney injury in intensive care units: a Veterans Administration study
    Charuhas V Thakar
    Nephrology, Cincinnati VA Medical Center, Cincinnati, OH, USA
    Crit Care Med 37:2552-8. 2009
    ..Acute kidney injury in intensive care unit patients is associated with significant mortality...
  62. ncbi Methicillin-resistant Staphylococcus aureus central line-associated bloodstream infections in US intensive care units, 1997-2007
    Deron C Burton
    Surveillance Branch, Division of Healthcare Quality Promotion, National Center for Preparedness, Detection, and Control of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    JAMA 301:727-36. 2009
    ..Concerns about rates of methicillin-resistant Staphylococcus aureus (MRSA) health care-associated infections have prompted calls for mandatory screening or reporting in efforts to reduce MRSA infections...
  63. ncbi Prevalence and mortality associated with cytomegalovirus infection in nonimmunosuppressed patients in the intensive care unit
    Andre C Kalil
    University of Nebraska Medical Center, Omaha, NE, USA
    Crit Care Med 37:2350-8. 2009
    ..Cytomegalovirus is the most common viral opportunistic infection in immunocompromised patients. However, recent studies have demonstrated active cytomegalovirus infection in nonimmunosuppressed intensive care unit patients...
  64. ncbi Nosocomial pneumonia after acute stroke: implications for neurological intensive care medicine
    Ruediger Hilker
    Department of Neurology, University Hospital, Cologne, Germany
    Stroke 34:975-81. 2003
    ..Only limited data are available on stroke-associated pneumonia (SAP) in specialized neurological intensive care units (NICUs)...
  65. ncbi Acute kidney injury in intensive care unit patients: a comparison between the RIFLE and the Acute Kidney Injury Network classifications
    José António Lopes
    Department of Nephrology and Renal Transplantation, Hospital de Santa Maria, Av, Prof, Egas Moniz, Lisboa 1649 035, Portugal
    Crit Care 12:R110. 2008
    ..We evaluated the incidence of acute kidney injury and compared the ability of the maximum RIFLE and of the maximum AKIN within intensive care unit hospitalization in predicting inhospital mortality of critically ill patients...
  66. ncbi Acute kidney injury in patients with sepsis: a contemporary analysis
    José António Lopes
    Department of Nephrology and Renal Transplantation, Hospital de Santa Maria, Av Prof Egas Moniz, 1649 035, Lisbon, Portugal
    Int J Infect Dis 13:176-81. 2009
    ....
  67. ncbi Mechanisms of neuromuscular dysfunction in critical illness
    Jaffar Khan
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Crit Care Clin 24:165-77, x. 2008
    ..Finally, a defective sodium channel regulation as a unifying mechanism underlying NMD in critically ill patients is proposed...
  68. ncbi Bacteremia in patients with ventilator-associated pneumonia is associated with increased mortality: A study comparing bacteremic vs. nonbacteremic ventilator-associated pneumonia
    Kemal Agbaht
    Critical Care Department, Joan XXIII University Hospital, University Rovira i Virgili, Institut Pere Virgili, Tarragona, Spain
    Crit Care Med 35:2064-70. 2007
    ..To assess whether bacteremic ventilator-associated pneumonia (B-VAP) differs in terms of risk factors, organisms, and outcomes from nonbacteremic VAP (NB-VAP)...
  69. ncbi Elevated nucleosome levels in systemic inflammation and sepsis
    Sacha Zeerleder
    University Hospital, Bern, Switzerland
    Crit Care Med 31:1947-51. 2003
    ..DESIGN: Retrospective study. SETTING: Medical and surgical wards or intensive care units of two university hospitals...
  70. ncbi Impact of clinical guidelines in the management of severe hospital-acquired pneumonia
    Guy W Soo Hoo
    Pulmonary and Critical Care Section 111Q, West Los Angeles Healthcare Center, VA Greater Los Angeles Healthcare System, Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90073, USA
    Chest 128:2778-87. 2005
    ..To asses the impact of locally developed antimicrobial treatment guidelines in the initial empiric treatment of ICU patients with severe hospital-acquired pneumonia (HAP)...
  71. ncbi Methicillin-resistant Staphylococcus aureus in a general intensive care unit
    D S Thompson
    Medway Maritime Hospital, Gillingham ME7 5NY, UK
    J R Soc Med 97:521-6. 2004
    Methicillin-resistant Staphylococcus aureus (MRSA) has presented special problems in intensive care units (ICUs) because of the difficulties in implementing infection control measures...
  72. ncbi Review of antibiotic drug use in a surgical ICU: management with a patient data management system for additional outcome analysis in patients staying more than 24 hours
    Bernd Hartmann
    Department of Anesthesiology, Intensive Care Medicine, and Pain Therapy, University Hospital Giessen, Giessen, Germany
    Clin Ther 26:915-24; discussion 904. 2004
    ..It would also be helpful to integrate certain therapy standards and reminder functions for the duration of therapy in the PDMS...
  73. ncbi Bloodstream infection due to Acinetobacter spp: epidemiology, risk factors and impact of multi-drug resistance
    D W Wareham
    Division of Infection, Barts and The London NHS Trust, London, UK
    Eur J Clin Microbiol Infect Dis 27:607-12. 2008
    ..A prospective study is required to identify both the most effective intervention and those most likely to benefit from treatment...
  74. ncbi Effect of acute kidney injury on weaning from mechanical ventilation in critically ill patients
    Jose M Vieira
    Oncologic Intensive Care Unit, Hospital do Câncer de São Paulo, Sao Paulo, Brazil
    Crit Care Med 35:184-91. 2007
    ..Acute kidney injury (AKI) worsens outcome in various scenarios. We sought to investigate whether the occurrence of AKI has any effect on weaning from mechanical ventilation...
  75. ncbi Intensive insulin therapy in the medical ICU
    Greet Van den Berghe
    Department of Intensive Care Medicine, Catholic University of Leuven, Leuven, Belgium
    N Engl J Med 354:449-61. 2006
    Intensive insulin therapy reduces morbidity and mortality in patients in surgical intensive care units (ICUs), but its role in patients in medical ICUs is unknown.
  76. ncbi Outcome of critically ill oldest-old patients (aged 90 and older) admitted to the intensive care unit
    Konstantinos Rellos
    Intensive Care Unit, Henry Dunant Hospital, Athens, Greece
    J Am Geriatr Soc 54:110-4. 2006
    ....
  77. ncbi [Infections caused by Acinetobacter spp. in critically ill ICU patients]
    Francisco Alvarez-Lerma
    Servicio de Medicina Intensiva, Hospital del Mar, Barcelona, Spain
    Enferm Infecc Microbiol Clin 23:533-9. 2005
    To determine the frequency of infections caused by Acinetobacter spp. in critically ill patients admitted to Spanish intensive care units (ICUs) and to assess the clinical features and outcome.
  78. ncbi A multi-centre evaluation of the RIFLE criteria for early acute kidney injury in critically ill patients
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta Hospital, 3C1 16 Walter C Mackenzie Centre, 8440 122 Street, Edmonton, Alberta T6G2B7, Canada
    Nephrol Dial Transplant 23:1203-10. 2008
    ..We sought to evaluate the RIFLE criteria on the day of ICU admission in a large heterogenous population of critically ill patients...
  79. ncbi Noninvasive ventilation in patients with "do-not-intubate" orders: medium-term efficacy depends critically on patient selection
    Rafael Fernandez
    Critical Care Center, Hospital de Sabadell, Parc Tauli s n, 08208, Sabadell, Spain
    Intensive Care Med 33:350-4. 2007
    ....
  80. ncbi Influence of matching for exposure time on estimates of attributable mortality caused by nosocomial bacteremia in critically ill patients
    Stijn Blot
    Intensive Care Department, Ghent University Hospital, Gent, Belgium
    Infect Control Hosp Epidemiol 26:352-6. 2005
    ..To evaluate the influence of matching on exposure time on estimates of attributable mortality of nosocomial bacteremia as assessed by matched cohort studies...
  81. ncbi Admission hypomagnesemia--impact on mortality or morbidity in critically ill patients
    Mohammadreza Safavi
    Department of Anesthesiology and Intensive Care Medicine, School of Medical Sciences, Isfahan University, Isfahan, Iran
    Middle East J Anesthesiol 19:645-60. 2007
    ..The aim of this study was to define the prevalence of admission hypomagnesemia in critically ill patients and to evaluate its relationship with organ dysfunction, length of stay, and mortality...
  82. ncbi Nursing Activities Score in the intensive care unit: analysis of the related factors
    Katia Grillo Padilha
    School of Nursing, University of Sao Paulo, Av Dr Eneas de Carvalho Aguiar 419, CEP 05403 000, Sao Paulo SP, Brazil
    Intensive Crit Care Nurs 24:197-204. 2008
    ..It is also important to be aware of the factors related to high patient care demands in order to help forecast staff requirements in intensive care units (ICUs).
  83. ncbi Visits to intensive care unit patients--frequency, duration and impact on outcome
    Thomas Eriksson
    Sahlgrenska University Hospital, Institute of Health and Care Sciences, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Nurs Crit Care 12:20-6. 2007
    ..Most of the older patients had no visitors, which indicates that elderly people may have a poorer social network; thus, there may be a greater need for professional caring relationships and care planning...
  84. ncbi Outcomes of acute respiratory distress syndrome (ARDS) in elderly patients
    Soumitra R Eachempati
    Division of Trauma and Critical Care, Department of Surgery, Weill Medical College of Cornell University, New York, New York, USA
    J Trauma 63:344-50. 2007
    ..We reviewed our experience with ARDS to determine whether outcomes were improving over time, and in particular whether outcomes were equally favorable among our elderly patients aged 65 years or older...
  85. ncbi Incidence and outcomes of ventilator-associated pneumonia in Japanese intensive care units: the Japanese nosocomial infection surveillance system
    Machi Suka
    Department of Preventive Medicine, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki, Kanagawa 216 8511, Japan
    Infect Control Hosp Epidemiol 28:307-13. 2007
    ....
  86. ncbi Feeding practices of severely ill intensive care unit patients: an evaluation of energy sources and clinical outcomes
    Mary E Hise
    The University of Kansas Medical Center, Department of Dietetics and Nutrition, Kansas City, KS 66160 7250, USA
    J Am Diet Assoc 107:458-65. 2007
    ..The primary objective of this study was to assess energy intake in severely ill ICU patients and to evaluate the relationship of energy intake with clinical outcomes...
  87. ncbi Influence of time-to-interventions for emergency department critical care patients on hospital mortality
    Karen Clark
    University of Maryland, Shady Grove Center, Rockville, MD 20850, USA
    J Emerg Nurs 33:6-13; quiz 90. 2007
    ....
  88. ncbi The effect of workload on infection risk in critically ill patients
    Stephane Hugonnet
    Infection Control Program, Department of Internal Medicine, University of Geneva Hospitals, Geneva, Switzerland
    Crit Care Med 35:76-81. 2007
    ..There is growing evidence that low nurse staffing jeopardizes quality of patient care. The objective of the study was to determine whether low staffing level increases the infection risk in critical care...
  89. ncbi At-risk drinkers are at higher risk to acquire a bacterial infection during an intensive care unit stay than abstinent or moderate drinkers
    Arnaud Gacouin
    Service de Maladies Infectieuses et Reanimation Medicale, Hopital Pontchaillou, Rennes, France
    Crit Care Med 36:1735-41. 2008
    ..To determine whether excessive alcohol consumption increases the risk for intensive care unit (ICU)-acquired bacterial infection, especially ventilator-associated pneumonia (VAP), in nontrauma patients...
  90. ncbi Admission hyperglycemia and other risk factors as predictors of hospital mortality in a medical ICU population
    Amado X Freire
    Division of Pulmonary Critical Care and Sleep Medicine, Department of Medicine, University of Tennessee Health Science Center, Memphis, 38163, USA
    Chest 128:3109-16. 2005
    ..Tight glycemic control is recommended for patients in the ICU, as hyperglycemia is associated with increased morbidity and mortality...
  91. ncbi Association between hyperglycemia and increased hospital mortality in a heterogeneous population of critically ill patients
    James Stephen Krinsley
    Division of Critical Care, The Stamford Hospital, Stamford, Conn 06902, USA
    Mayo Clin Proc 78:1471-8. 2003
    ..To investigate the relationship between hyperglycemia and hospital mortality in a heterogeneous group of critically ill patients...
  92. ncbi Outcome and attributable cost of ventilator-associated pneumonia among intensive care unit patients in a suburban medical center
    David K Warren
    Division of Infectious Diseases, Washington University School of Medicine, St Louis, MO 63110, USA
    Crit Care Med 31:1312-7. 2003
    ..To determine the attributable cost of ventilator-associated pneumonia from a hospital-based cost perspective, after adjusting for potential confounders...
  93. ncbi Comparison of a high-protein disease-specific enteral formula with a high-protein enteral formula in hyperglycemic critically ill patients
    A Mesejo
    Intensive Care Unit, Hospital General Universitario, Alicante, Spain
    Clin Nutr 22:295-305. 2003
    ..DESIGN: A prospective, randomized, controlled, single-blind trial in two University Hospital Intensive Care Units in Spain...
  94. ncbi Impact of exclusion criteria on case mix, outcome, and length of stay for the severity of disease scoring methods in common use in critical care
    Hannah Wunsch
    Department of Medicine, Columbia University, New York-Presbyterian Hospital, New York, NY, USA
    J Crit Care 19:67-74. 2004
    ..the impact of the exclusion criteria on the case mix, outcomes and length of stay for admissions to intensive care units (ICUs) in England, Wales and Northern Ireland...
  95. ncbi Predictive accuracy of severity scoring system: a prospective cohort study using APACHE III in a Korean intensive care unit
    Jeong Ihnsook
    Department of Nursing, College of Medicine, Pusan National University, 1 10 Ami dong Seo gu, 602 739 Pusan, South Korea
    Int J Nurs Stud 40:219-26. 2003
    ..To evaluate the discrimination, calibration, and uniformity of fit by age group, operative status, and location before ICU admission of APACHE III in a single-center ICU population...
  96. ncbi Steroid-induced myopathy in patients intubated due to exacerbation of chronic obstructive pulmonary disease
    Rosario Amaya-Villar
    Intensive Care Unit, University Hospital Virgen del Rocio, Avenida Manuel Siurot s n, 41013 Seville, Spain
    Intensive Care Med 31:157-61. 2005
    ..To determine incidence, risk factors and impact on various outcome parameters of the development of acute quadriplegic myopathy in a selected population of critically ill patients...
  97. ncbi Impact of ventilator-associated pneumonia on resource utilization and patient outcome
    Stephane Hugonnet
    Infection Control Program, Department of Internal Medicine, University of Geneva Hospitals, Geneva, Switzerland
    Infect Control Hosp Epidemiol 25:1090-6. 2004
    ..To assess the effect of ventilator-associated pneumonia on resource utilization, morbidity, and mortality...
  98. ncbi Length of stay and mortality in neurocritically ill patients: impact of a specialized neurocritical care team
    Jose I Suarez
    Neurosciences Critical Care, The Department of Neurology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH, USA
    Crit Care Med 32:2311-7. 2004
    ....
  99. ncbi Risk of mortality with a bloodstream infection is higher in the less severely ill at admission
    Peter W Kim
    VA Maryland Health Care System, 100 N. Greene St. (Lower level, Baltimore, MD 21201, USA
    Am J Respir Crit Care Med 171:616-20. 2005
    ..Focusing interventions to prevent bloodstream infections in less severely ill patients would be expected to have a greater benefit in terms of mortality reduction...
  100. ncbi Reappraisal of attributable mortality in critically ill patients with nosocomial bacteraemia involving Pseudomonas aeruginosa
    S Blot
    Department of Intensive Care, Ghent University Hospital, Belgium
    J Hosp Infect 53:18-24. 2003
    ..In conclusion, P. aeruginosa bacteraemia is associated with a clinically relevant attributable mortality (15%). However, we could not find statistical evidence of P. aeruginosa being an independent predictor of mortality...
  101. ncbi Blood usage in an Australian intensive care unit: have we met best practice goals?
    D Farrar
    Intensive Care Unit and Haematology Department, The Royal Melbourne Hospital, Melbourne, Victoria
    Anaesth Intensive Care 32:775-80. 2004
    ..10, 95% CI 0.02-0.58). The low red cell concentrate and blood product usage in our ICU were consistent with restrictive transfusion practice and selective red cell concentrate transfusion was associated with reduced mortality...

Research Grants84

  1. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    T O SHEA; Fiscal Year: 2005
    ..in this region there are approximately 20,000 births, including 1400 who are admitted to the WFUSM neonatal intensive care units, and 270 who are very low birth weight...
  2. Bilirubin-induced Auditory Neuropathy in Preterms
    SANJIV AMIN; Fiscal Year: 2007
    ..The OAE reflects cochlear function and is the current standard of care in many Neonatal Intensive Care Units (NICU) for hearing screening...
  3. Effects of Noise on Newborns < 1000g Birthweight
    Robert Lasky; Fiscal Year: 2007
    Noise levels in neonatal intensive care units (NICUs) may have serious adverse effects on high risk infants by increasing apneic, bradycardic, or desaturation episodes; sleep disturbances; mechanical ventilation; hospital stay; poor ..
  4. Biomarker Profiles for Early Diagnosis of Sepsis in Neonates
    James Mapes; Fiscal Year: 2007
    Sepsis is a frequent and serious problem in neonatal intensive care units, particularly in very low birth weight (VLBW) infants. Over 20% of all VLBW infants experience one or more episodes of late-onset sepsis...
  5. Prevention of Nosocomial Infections and Cost-Effectiveness Refined (P-NICER)
    Patricia W Stone; Fiscal Year: 2010
    ..major contributor to increased morbidity, mortality and hospital costs;and, the majority of these occur in intensive care units (ICUs) and many are associated with insertion of an invasive device...
  6. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Maragakis; Fiscal Year: 2009
    ..increasingly the cause of a variety of serious infections in hospitalized patients, particularly those in intensive care units. Therapeutic choices for these infections are severely limited since many of these MDR organisms have ..
  7. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Maragakis; Fiscal Year: 2007
    ..increasingly the cause of a variety of serious infections in hospitalized patients, particularly those in intensive care units. Therapeutic choices for these infections are severely limited since many of these MDR organisms have ..
  8. AMELIORATION OF SEPSIS BY MACROPHAGE ACTIVATION
    David Williams; Fiscal Year: 1999
    ..advances in critical care, sepsis continues to be a pivotal factor in 40% to 60% of deaths in surgical intensive care units. Sepsis syndrome occurs in 500,000 patients per year and is the 13th most common cause of death in the ..
  9. Palliation of Thirst in Intensive Care Unit Patients
    Kathleen Puntillo; Fiscal Year: 2009
    ..most pervasive, intense, unrecognized, and under-treated symptoms suffered by critically ill patients in Intensive Care Units (ICUs)...
  10. Mechanisms of Novel Herbal Therapies for Sepsis.
    Haichao Wang; Fiscal Year: 2010
    ..advance in antibiotic therapy and intensive care, sepsis remains the most common cause of death in the intensive care units, claiming >225,000 victims annually in the U.S. alone...
  11. Applied Research in Antimicrobial Resistance: Studies of Susceptibility Testing
    Lisa Saiman; Fiscal Year: 2007
    ..today, the 'post-antimicrobial era' has been looming for well over a decade as patients, particularly in intensive care units (ICUs), are increasingly developing infections caused by multidrug-resistant (MDR) pathogens...
  12. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Saiman; Fiscal Year: 2009
    ..the 'post-antimicrobial era' has been looming for well over a decade as patients, particularly in intensive care units (ICUs), are increasingly developing infections caused by multidrug-resistant (MDR) pathogens...
  13. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    Jon Tyson; Fiscal Year: 2003
    ..John C. Sinclair, MD, an eminent neonatologist, clinical epidemiologist, and Network advisor, will join the Center Jan. 2001. ..
  14. Standardized Rehabilitation for ICU Patients with Acute Respiratory Failure
    Peter E Morris; Fiscal Year: 2010
    ..1 million of the 4.4 million people admitted to US Intensive Care Units (ICU) every year...
  15. Standardized Rehabilitation for ICU Patients with Acute Respiratory Failure
    Peter Morris; Fiscal Year: 2009
    ..1 million of the 4.4 million people admitted to US Intensive Care Units (ICU) every year...
  16. NEOPAIN MULTICENTER TRIAL: DATA COORDINATING CENTER
    Bruce Barton; Fiscal Year: 2001
    ..Analgesic practices recorded prospectively in 109 Neonatal Intensive Care Units (NICUs) showed that opioids and benzodiazepines were most commonly used, with large variations in clinical ..
  17. Mesenteric Lymph Linking Gut & Distant Organ Injury
    Edwin Deitch; Fiscal Year: 2007
    Trauma is the leading cause of death in people under the age of 40 and MODS is the leading cause of death in intensive care units. Consequently, understanding the mechanisms by which trauma-hemorrhagic shock (T/HS) leads to MODS is of ..
  18. Platelet Transfusions in the Neonatal Intensive Care Unit
    Martha Sola Visner; Fiscal Year: 2007
    ..is a common problem among sick newborn infants, affecting 20-35% of all patients admitted to Neonatal Intensive Care Units (NICUs)...
  19. Identifying Effective Strategies to Disclose Prognosis in Patients with ARDS
    Douglas White; Fiscal Year: 2009
    ..Three decades of research on end-of-life care in the United States indicates that Americans dying in intensive care units often spend their final days receiving life sustaining treatment they would not choose...
  20. Identifying Effective Strategies to Disclose Prognosis in Patients with ARDS
    Douglas B White; Fiscal Year: 2010
    ..Three decades of research on end-of-life care in the United States indicates that Americans dying in intensive care units often spend their final days receiving life sustaining treatment they would not choose...
  21. MICROVASCULAR ABNORMALITIES IN SEPSIS
    Steven Hollenberg; Fiscal Year: 2002
    Septic shock, the leading cause of death in intensive care units, is characterized by vasodilation with decreased peripheral vascular resistance, which is often refractory to exogenously administered vasopressor agents...
  22. DEVELOPING CIRCADIAN RHYTHMICITY
    Scott Rivkees; Fiscal Year: 2002
    ..In neonatal intensive care units, preterm infants are typically exposed to continuous dim lighting without photic time-of-day cues...