palau

Summary

Summary: A republic consisting of a group of about 100 islands and islets in the western Pacific Ocean. Its capital is Koror. Under Spain it was administered as a part of the Caroline Islands but was sold to Germany in 1899. Seized by Japan in 1914, it was taken by the Allies in World War II in 1944. In 1947 it became part of the U.S. Trust Territory of the Pacific Islands, became internally self-governing in 1980, obtained independent control over its foreign policy (except defense) in 1986, and achieved total independence October 1, 1994. (Webster's New Geographical Dictionary, 1988, p915; telephone communication with Randy Flynn, Board on Geographic Names, 17 January 1995)

Top Publications

  1. ncbi Isolations of N-methyl-D-aspartic acid-type glutamate receptor ligands from Micronesian sponges
    Ryuichi Sakai
    Kitasato University School of Fisheries Sciences, Sanriku cho, Ofunato, Iwate 022 0101 Japan
    J Nat Prod 66:784-7. 2003
  2. ncbi Genetic liability to schizophrenia in Oceanic Palau: a search in the affected and maternal generation
    Bernie Devlin
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Hum Genet 121:675-84. 2007
  3. pmc Scrub typhus, Republic of Palau
    Linda J Demma
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 12:290-5. 2006
  4. pmc The Palau Early Psychosis Study: distribution of cases by level of genetic risk
    Marina Myles-Worsley
    Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Am J Med Genet B Neuropsychiatr Genet 144:5-9. 2007
  5. ncbi The structure of Palau'amide, a potent cytotoxin from a species of the marine cyanobacterium Lyngbya
    Philip G Williams
    Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA
    J Nat Prod 66:1545-9. 2003
  6. ncbi Managing health care system in small island countries: Palau
    Stevenson Kuartei
    Bureau of Public Health Services, Ministry of Health, Koror, Republic of Palau
    Pac Health Dialog 13:143-50. 2006
  7. ncbi New apratoxins of marine cyanobacterial origin from Guam and Palau
    Hendrik Luesch
    Department of Chemistry, University of Hawaii at Manoa, 96822, Honolulu, HI, USA
    Bioorg Med Chem 10:1973-8. 2002
  8. doi Archaeology: bones, isles and videotape
    Rex Dalton
    Nature 452:806-8. 2008
  9. ncbi Genome-wide multipoint linkage analyses of multiplex schizophrenia pedigrees from the oceanic nation of Palau
    B Devlin
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Mol Psychiatry 7:689-94. 2002
  10. ncbi Comparative analysis of oral health indicators among young children in Hawai'i, the Republic of Palau and Territory of Guam, 1999-2000
    Mark H K Greer
    Dental Health Division, Department of Health, State of Hawai i, Honolulu, Hawai i, USA
    Pac Health Dialog 10:6-11. 2003

Research Grants

Detail Information

Publications154 found, 100 shown here

  1. ncbi Isolations of N-methyl-D-aspartic acid-type glutamate receptor ligands from Micronesian sponges
    Ryuichi Sakai
    Kitasato University School of Fisheries Sciences, Sanriku cho, Ofunato, Iwate 022 0101 Japan
    J Nat Prod 66:784-7. 2003
    ..bioassay-guided fractionation of the water-soluble extract of the marine sponge Cribrochalina olemda collected in Palau resulted in the isolation of a new amino acid cribronic acid (1): (2S,4R,5R)-5-hydroxy-4-sulfooxypiperidine-2-..
  2. ncbi Genetic liability to schizophrenia in Oceanic Palau: a search in the affected and maternal generation
    Bernie Devlin
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Hum Genet 121:675-84. 2007
    ..Regions in which at least two adjacent markers produced substantial association statistics include 2p12-11.2, 2q24.1-32.1, 6q12-14.1, 10q23.2-24.21, 12q23.2-24.21 and 17q23.2-23.3...
  3. pmc Scrub typhus, Republic of Palau
    Linda J Demma
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 12:290-5. 2006
    ..The first known outbreak of scrub typhus in Palau occurred in 2001 to 2003 among residents of the remote southwest islands...
  4. pmc The Palau Early Psychosis Study: distribution of cases by level of genetic risk
    Marina Myles-Worsley
    Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Am J Med Genet B Neuropsychiatr Genet 144:5-9. 2007
    The Palau Early Psychosis Study (PEPS) was designed to examine the pathogenesis of early psychosis in a high-risk population isolate...
  5. ncbi The structure of Palau'amide, a potent cytotoxin from a species of the marine cyanobacterium Lyngbya
    Philip G Williams
    Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA
    J Nat Prod 66:1545-9. 2003
    Bioassay-guided fractionation of the extract of a species of Lyngbya from Palau has yielded Palau'amide (1), which had an IC(50) value of 13 nM against KB cells. The structure of 1 was elucidated by NMR analysis in a variety of solvents...
  6. ncbi Managing health care system in small island countries: Palau
    Stevenson Kuartei
    Bureau of Public Health Services, Ministry of Health, Koror, Republic of Palau
    Pac Health Dialog 13:143-50. 2006
    ..It will outline a step approach toward realignment and reengineering a viable health care system that is hopefully both cost effective and outcome oriented...
  7. ncbi New apratoxins of marine cyanobacterial origin from Guam and Palau
    Hendrik Luesch
    Department of Chemistry, University of Hawaii at Manoa, 96822, Honolulu, HI, USA
    Bioorg Med Chem 10:1973-8. 2002
    Two collections of the marine cyanobacterium Lyngbya sp. from Guam and Palau that both afforded the potent cytotoxin apratoxin A (1) each yielded different structural analogues with lower degrees of methylation...
  8. doi Archaeology: bones, isles and videotape
    Rex Dalton
    Nature 452:806-8. 2008
  9. ncbi Genome-wide multipoint linkage analyses of multiplex schizophrenia pedigrees from the oceanic nation of Palau
    B Devlin
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Mol Psychiatry 7:689-94. 2002
    The oceanic nation of Palau has been geographically and culturally isolated over most of its 2000 year history...
  10. ncbi Comparative analysis of oral health indicators among young children in Hawai'i, the Republic of Palau and Territory of Guam, 1999-2000
    Mark H K Greer
    Dental Health Division, Department of Health, State of Hawai i, Honolulu, Hawai i, USA
    Pac Health Dialog 10:6-11. 2003
    Dental caries prevalence data were collected in Hawai'i, Palau and Guam and analyzed for dft, DMFT, unmet treatment needs, sealant utilization and various caries patterns...
  11. ncbi The effects of an indigenous muscarinic drug, Betel nut (Areca catechu), on the symptoms of schizophrenia: a longitudinal study in Palau, Micronesia
    Roger J Sullivan
    Department of Anthropology, California State University, Sacramento, CA 95819 6106, USA
    Am J Psychiatry 164:670-3. 2007
    ..This study tested the findings of a prior study indicating a therapeutic relationship between consumption of betel nut and symptoms of schizophrenia...
  12. ncbi A single cyanobacterial ribotype is associated with both red and black bands on diseased corals from Palau
    Meir Sussman
    James Cook University, School of Marine Biology and Aquaculture, Townsville 4811, Queensland, Australia
    Dis Aquat Organ 69:111-8. 2006
    Filamentous cyanobacteria forming red and black bands (black band disease, BBD) on 3 scleractinian corals from Palau were molecularly identified as belonging to a single ribotype...
  13. doi Pacific "dwarf" bones cause controversy
    Rex Dalton
    Nature 452:133. 2008
  14. ncbi Linkage analysis of a completely ascertained sample of familial schizophrenics and bipolars from Palau, Micronesia
    Lambertus Klei
    Department of Statistics, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Hum Genet 117:349-56. 2005
    ..linkage analysis of a completely ascertained population of familial psychosis derived from the oceanic nation of Palau. Palau, an archipelago of islands in the Southern Pacific, currently has a population of approximately 23,000 ..
  15. pmc Scrub typhus in the Republic of Palau, Micronesia
    A Mark Durand
    Department of Health Services, Yap State, Colonia, Yap, Federated States of Micronesia 96943
    Emerg Infect Dis 10:1838-40. 2004
    In October 2001, an outbreak of febrile illness began in the southwest islands group of the Republic of Palau. Through October 2003, a total of 15 southwest islanders experienced fever >39...
  16. ncbi Spatial working memory deficits in schizophrenia patients and their first degree relatives from Palau, Micronesia
    Marina Myles-Worsley
    Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Am J Med Genet 114:609-15. 2002
    ..memory function in affected and unaffected members of multiplex schizophrenia families from the Republic of Palau to determine whether the spatial working memory deficits associated with schizophrenia extend to this non-..
  17. ncbi Genome-wide distribution of linkage disequilibrium in the population of Palau and its implications for gene flow in Remote Oceania
    B Devlin
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213 2593, USA
    Hum Genet 108:521-8. 2001
    ..of LD between short tandem repeat alleles on autosomes and sex chromosomes in the Remote Oceanic population of Palau to evaluate whether the data are consistent with a recent hypothesis about the origins of genetic variation in ..
  18. ncbi Outbreak of dengue fever in Palau, Western Pacific: risk factors for infection
    David A Ashford
    Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 69:135-40. 2003
    Between January and June 1995, an outbreak of dengue fever occurred in Palau, an island nation of 32,000 inhabitants in the Western Pacific...
  19. ncbi Lyngbyaloside B, a new glycoside macrolide from a Palauan marine cyanobacterium, Lyngbya sp
    Hendrik Luesch
    Department of Chemistry, University of Hawaii at Manoa, Honolulu, HI 96822, USA
    J Nat Prod 65:1945-8. 2002
    ..The relative stereochemistry for the 12 stereocenters is proposed on the basis of proton-proton spin-coupling constants and ROESY data...
  20. ncbi Botryllamides E-H, four new tyrosine derivatives from the ascidian Botrylloides tyreum
    M Rama Rao
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093 0212, USA
    J Nat Prod 67:1064-6. 2004
    A specimen of the ascidian Botrylloides tyreum from Palau contained the known metabolites botryllamides A (5) and C (7) together with four new tyrosine derivatives, botryllamides E-H (1-4), the structures of which were elucidated by ..
  21. ncbi Crambescidin 826 and dehydrocrambine A: new polycyclic guanidine alkaloids from the marine sponge Monanchora sp. that inhibit HIV-1 fusion
    LengChee Chang
    Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland 20892 0820
    J Nat Prod 66:1490-4. 2003
    ....
  22. pmc Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella
    Eric W Schmidt
    Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 102:7315-20. 2005
    ..In addition, a related cluster was identified in Trichodesmium erythraeum IMS101, an important bloom-forming cyanobacterium...
  23. ncbi Tasipeptins A and B: new cytotoxic depsipeptides from the marine cyanobacterium Symploca sp
    Philip G Williams
    Department of Chemistry, University of Hawaii at Manoa, Honolulu 96822, USA
    J Nat Prod 66:620-4. 2003
    Two new depsipeptides have been isolated from a Symploca sp. collected in Palau. The gross structures of tasipeptins A (1) and B (2) were determined by standard spectroscopic techniques, and the absolute configuration of the amino acid ..
  24. ncbi Caulibugulones A-F, novel cytotoxic isoquinoline quinones and iminoquinones from the marine bryozoan Caulibugula intermis
    Dennis J Milanowski
    Molecular Targets Development Program, Center for Cancer Research, National Cancer Institute, Building 1052, Room 121, Frederick, MD 21702 1201, USA
    J Nat Prod 67:70-3. 2004
    An extract of the marine bryozoan Caulibugula intermis, collected in the Indo-Pacific off Palau, produced a distinct pattern of differential cytotoxicity in the National Cancer Institute's 60 cell line antitumor screen...
  25. ncbi A new antifouling hexapeptide from a Palauan sponge, Haliclona sp
    Yutaka Sera
    Marine Biotechnology Institute, 75 1 Heita, Kamaishi 026 0001, Japan
    J Nat Prod 66:719-21. 2003
    ..The structures of hexapeptides 1 and 2 were elucidated by extensive NMR analyses and the advanced Marfey's method with LC/MS. These compounds showed repellent activity against the blue mussel, Mytilus edulis galloprovincialis...
  26. ncbi The isolation and structure elucidation of Tasiamide B, a 4-amino-3-hydroxy-5-phenylpentanoic acid containing peptide from the marine Cyanobacterium Symploca sp
    Philip G Williams
    Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA
    J Nat Prod 66:1006-9. 2003
    ..The configuration of 1 was deduced by HPLC analysis of degradation products...
  27. ncbi Tasiamide, a cytotoxic peptide from the marine cyanobacterium Symploca sp
    Philip G Williams
    Department of Chemistry, University of Hawaii at Manoa, Honolulu 96822, USA
    J Nat Prod 65:1336-9. 2002
    ..The planar structure and absolute stereochemistry of the peptide were deduced by 2D NMR techniques and chiral HPLC. Tasiamide (1) was cytotoxic against KB and LoVo cells with IC(50) values of 0.48 and 3.47 microg/mL, respectively...
  28. ncbi Hexaprenoid hydroquinones from the sponge Haliclona (aka Adocia) sp
    Lyndon M West
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093 0212F, USA
    J Nat Prod 69:1001-4. 2006
    ..The structures of these compounds were elucidated by interpretation of spectroscopic data...
  29. ncbi Localization studies of ioactive cyclic peptides in the ascidian Lissoclinum patella
    Christine E Salomon
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093 0212, USA
    J Nat Prod 65:689-92. 2002
    ..but were instead distributed throughout the ascidian tunic. The relevance of these results with respect to the biosynthetic origins of the patellamides is discussed...
  30. ncbi New cytotoxic N-methylated beta-carboline alkaloids from the marine ascidian Eudistoma gilboverde
    M A Rashid
    Intramural Research Support Program, SAIC-Frederick, NCI-Frederick, Maryland 21702-1201, USA
    J Nat Prod 64:1454-6. 2001
    ..Of the three new compounds, 14-methyleudistomidin C (3) exhibited the most potent cytotoxic activity with IC(50)'s of < 1.0 microg/mL against four different human tumor cell lines...
  31. pmc Morphological, chemical, and genetic diversity of tropical marine cyanobacteria Lyngbya spp. and Symploca spp. (Oscillatoriales)
    Robert W Thacker
    Department of Biology, University of Alabama at Birmingham, Birmingham, AL 35294 1170, USA
    Appl Environ Microbiol 70:3305-12. 2004
    ..majuscula Gomont, Lyngbya spp., and Symploca spp. from Guam and the Republic of Palau. The morphological characteristics examined were cell length, cell width, and the presence or absence of a ..
  32. ncbi Speciation and biosynthetic variation in four dictyoceratid sponges and their cyanobacterial symbiont, Oscillatoria spongeliae
    Christian P Ridley
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093, USA
    Chem Biol 12:397-406. 2005
    ..contain the filamentous cyanobacterial symbiont Oscillatoria spongeliae, were collected from four locations in Palau. The halogenated natural products associated with the symbiont were characterized from each sample, revealing that ..
  33. ncbi Preventive intervention for early psychosis in adolescents--the Palau Youth at Risk Project
    Hilda Ngiralmau
    Ministry of Health, Republic of Palau, Koror, Palau 96940
    Pac Health Dialog 12:43-6. 2005
    We have studied a total of 393 adolescents 14 to 19 years from Palau, where the lifetime morbid risk for broadly defined schizophrenia is 2.67% and cases cluster in large extended families...
  34. ncbi Surveillance for waterborne disease and outbreaks associated with recreational water use and other aquatic facility-associated health events--United States, 2005-2006
    Jonathan S Yoder
    Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne, and Enteric Diseases, CDC, Atlanta, GA 30341, USA
    MMWR Surveill Summ 57:1-29. 2008
    ..In addition, data are collected on individual cases of recreational water-associated illnesses and infections and health events occurring at aquatic facilities but not directly related to water exposure...
  35. ncbi Surveillance for waterborne disease and outbreaks associated with drinking water and water not intended for drinking--United States, 2003-2004
    Jennifer L Liang
    Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne, and Enteric Diseases proposed, CDC, Atlanta, GA 30341, USA
    MMWR Surveill Summ 55:31-65. 2006
    ..This surveillance system is the primary source of data concerning the scope and effects of WBDOs in the United States...
  36. ncbi Surveillance for waterborne disease and outbreaks associated with drinking water and water not intended for drinking--United States, 2005-2006
    Jonathan Yoder
    Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne, and Enteric Diseases, CDC, Atlanta, GA 30341, USA
    MMWR Surveill Summ 57:39-62. 2008
    ..This surveillance system is the primary source of data concerning the scope and effects of waterborne disease in the United States...
  37. ncbi Tobacco smoking prevalence in Pacific Island countries and territories: a review
    Kumanan Rasanathan
    Section of Pacific and International Health, School of Population Health, University of Auckland, Auckland, New Zealand
    N Z Med J 120:U2742. 2007
    ..To comprehensively review adult and youth smoking prevalence data in Pacific Island countries and territories (PICT)...
  38. pmc Reducing cancer health disparities in the US-associated Pacific
    JoAnn U Tsark
    Imi Hale Native Hawaiian Cancer Network, Honolulu, Hawaii 96813, USA
    J Public Health Manag Pract 13:49-58. 2007
    ..control capacity in the US-associated Pacific Islands (USAPI, including American Samoa, Northern Mariana Islands, Micronesia, Guam, Marshall Islands, and Palau) and to support indigenous leadership in reducing cancer health disparities.
  39. ncbi The Yap AHEC: an update 2002-2006
    A Mark Durand
    Yap Area Health Education Center AHEC, Yap State Department of Health Service, Colonia, Yap State, Federated States of Micronesia FSM 96943
    Pac Health Dialog 14:234-8. 2007
    ..S.-Affiliated Pacific Island jurisdictions (together with those in Palau and the Commonwealth of the Northern Mariana Islands)...
  40. ncbi Pacific basin health worker training in the United States-Affiliated Pacific Islands: needs assessment and priorities for a continuing health care professional development program: executive summary
    Tai Ho Chen
    Department of Family Medicine and Community Health, John A Burns School of Medicine, University of Hawai i at Manoa, Mililani, Hawai i 96789 1192, USA
    Pac Health Dialog 14:15-21. 2007
    ..States: the Federated States of Micronesia (FSM), the Republic of the Marshall Islands (RMI) and the Republic of Palau. These six jurisdictions span four time zones and are separated by over 4,000 miles of the Pacific...
  41. ncbi Phylogenetic analysis and taxonomic study of marine Cytophaga-like bacteria: proposal for Tenacibaculum gen. nov. with Tenacibaculum maritimum comb. nov. and Tenacibaculum ovolyticum comb. nov., and description of Tenacibaculum mesophilum sp. nov. and Ten
    M Suzuki
    Marine Biotechnology Institute, Kamaishi Laboratories, Iwate, Japan
    Int J Syst Evol Microbiol 51:1639-52. 2001
    Bacterial strains were isolated from sponge and green algae which were collected on the coast of Japan and Palau. The phylogenetic relationships of these isolates among marine species of the Cytophaga-Flavobacterium-Bacteroides complex ..
  42. ncbi Suicide and suicidal-related behaviors among indigenous Pacific Islanders in the United States
    Iwalani R N Else
    National Center on Indigenous Hawaiian Behavioral Health, Department of Psychiatry, John A Burns School of Medicine, University of Hawai i at Manoa, Honolulu, Hawai i, USA
    Death Stud 31:479-501. 2007
    ..Islands, and the Pacific Island Nations of Micronesia (Federated States of Micronesia, the Republic of Belau [Palau], and the Republic of the Marshall Islands)...
  43. ncbi Assessing physicians' continuing medical education (CME) needs in the U.S.-associated Pacific jurisdictions
    Matthew J Thompson
    WWAMI Center for Health Workforce Studies and Department of Family Medicine, University of Washington, Seattle, WA, 98195 4696, USA
    Pac Health Dialog 9:11-6. 2002
    ..the self-perceived continuing medical education (CME) needs of physicians in American Samoa, Commonwealth of the Northern Mariana Islands, Guam, Federated States of Micronesia, Republic of the Marshall Islands, and the Republic of Palau.
  44. doi Gene flow of Acanthaster planci (L.) in relation to ocean currents revealed by microsatellite analysis
    Nina Yasuda
    National Research Institute of Fisheries and Environment of Inland Sea, Fisheries Research Agency, 2 17 5 Maruishi, Hatsukaichi, Hiroshima, Japan
    Mol Ecol 18:1574-90. 2009
    ..is, the Southeast African group (Kenya and Mayotte), the Northwestern Pacific group (the Philippines and Japan), Palau, the North Central Pacific group (Majuro and Pohnpei), the Great Barrier Reef, Fiji, and French Polynesia, with a ..
  45. ncbi Multicentre survey of incidence and public health impact of leptospirosis in the Western Pacific
    Alain Berlioz-Arthaud
    Institut Pasteur de Nouvelle Caledonie, BP 61, 98845 Nouméa cedex, New Caledonia
    Trans R Soc Trop Med Hyg 101:714-21. 2007
    ..from seven islands: Futuna, Raiatea and the Marquesas Islands where outbreaks were apparent, and Vanuatu, Fiji, Palau and Wallis where sporadic cases indicated at least the presence of the disease...
  46. ncbi Diabetes today in the Pacific: reports from the field
    Nia T Aitaoto
    The Pacific Diabetes Today Resource Center PDTRC of Papa Ola Lokahi, Honolulu, HI, USA
    Pac Health Dialog 12:124-31. 2005
    ..to assist communities in Hawai'i, American Samoa, Guam, Commonwealth of the Northern Mariana Islands, Republic of Palau, Federated States of Micronesia, and the Republic of the Marshall Islands to develop, implement, and evaluate ..
  47. ncbi Empowerment through community building: Diabetes Today in the Pacific
    Kathryn L Braun
    Pacific Diabetes Today Resource Center, Papa Ola Lokahi, 894 Queen Street, Honolulu, HI 96813, USA
    J Public Health Manag Pract . 2003
    ..of the Northern Marianas Islands, the Federated States of Micronesia, the Republic of the Marshall Islands, and Palau. PDTRC's work is guided by the principles of community building and the goal of empowering coalitions to take ..
  48. ncbi mtDNA lineage analyses: origins and migrations of Micronesians and Polynesians
    J K Lum
    The Institute of Statistical Mathematics, 4 6 7 Minami Azabu, Minato ku, Tokyo 106 8569, Japan
    Am J Phys Anthropol 113:151-68. 2000
    ..b>Palau clearly demonstrates a complex prehistory including a significant influx of lineages from New Guinea...
  49. ncbi Phylogeny of giant clams (Cardiidae: Tridacninae) based on partial mitochondrial 16S rDNA gene sequences
    J A Schneider
    Department of Biology, University of Michigan, Ann Arbor, Michigan 48109 1079, USA
    Mol Phylogenet Evol 13:59-66. 1999
    ..porcellanus (Palau and the Sulu Archipelago) and T. tevoroa (Tonga and Fiji)...
  50. pmc The age and origin of the Pacific islands: a geological overview
    Vincent E Neall
    Institute of Natural Resources, Massey University, Palmerston North, New Zealand
    Philos Trans R Soc Lond B Biol Sci 363:3293-308. 2008
    ..The geology of 10 exemplar archipelagos (Japan, Izu-Bonin, Palau, Solomons, Fiji, New Caledonia, New Zealand, Society, Galápagos and Hawaii) is then discussed in detail.
  51. ncbi Palau assessment for a continuing health care professional development program
    Tai Ho Chen
    Department of Family Medicine and Community Health, John A Burns School of Medicine, University of Hawai i at Manoa, Mililani, Hawai i 96789 1192, USA
    Pac Health Dialog 14:73-80. 2007
    ..This article highlights findings of PACT's Palau assessment...
  52. ncbi The spasmolytic effect of Aloysia citriodora, Palau (South American cedrón) is partially due to its vitexin but not isovitexin on rat duodenums
    María Inés Ragone
    Catedra de Farmacologia, Departamento de Ciencias Biologicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115 1900, La Plata, Argentina
    J Ethnopharmacol 113:258-66. 2007
    ..This plant (Aloysia citriodora Palau, Verbenaceae) is widely used for gastrointestinal disorders and as eupeptic in South America...
  53. ncbi Border control measures in the influenza pandemic plans of six South Pacific nations: a critical review
    Melissa McLeod
    Department of Public Health, Wellington School of Medicine and Health Sciences, Wellington South, New Zealand
    N Z Med J 121:62-72. 2008
    ..This study aimed to review the border control strategies included in the publicly available pandemic preparedness plans for the South Pacific Islands, New Zealand, and Australia...
  54. ncbi Mutation screening of a neutral amino acid transporter, ASCT1, and its potential role in schizophrenia
    P J Bennett
    Department of Psychiatry, School of Medicine, University of Utah, Salt Lake City 84132, USA
    Psychiatr Genet 10:79-82. 2000
    In a previous study, a genome scan of a subset of schizophrenia families from Palau, Micronesia gave evidence suggestive of linkage to microsatellite markers at 2p13-14...
  55. ncbi The role of low cost communications in health in the redevelopment of the indigenous physician workforce among selected jurisdictions of the US-associated Pacific Islands
    G Dever
    Bureau of Clinical Services, Ministry of Health, Republic of Palau
    Pac Health Dialog 7:63-7. 2000
    ..the Freely Associated States of the Federated States of Micronesia and the Republics of the Marshall Islands and Palau. These objectives were to: conduct a basic medical education program which graduated 70 physicians; promote ..
  56. doi A new chlorophyll d-containing cyanobacterium: evidence for niche adaptation in the genus Acaryochloris
    Remus Mohr
    Faculty of Biology, University of Freiburg, Schaenzlestrasse 1, Freiburg, Germany
    ISME J 4:1456-69. 2010
    ..marina, which were isolated from waters around the Palau islands (Pacific Ocean) and the Salton Sea lake (California), suggesting that it belongs to a different clade ..
  57. doi Pseudoscillatoria coralii gen. nov., sp. nov., a cyanobacterium associated with coral black band disease (BBD)
    Diana Rasoulouniriana
    Unit of Environmental Engineering, Ben Gurion University of the Negev, PO Box 653, Be er Sheva 84105, Israel
    Dis Aquat Organ 87:91-6. 2009
    ..e. the Caribbean Sea, Palau and the Red Sea)...
  58. pmc Small-bodied humans from Palau, Micronesia
    Lee R Berger
    Institute for Human Evolution corrected Bernard Price Institute for Palaeontology, School of Geosciences, University of the Witwatersrand, Johannesburg, South Africa
    PLoS ONE 3:e1780. 2008
    Newly discovered fossil assemblages of small bodied Homo sapiens from Palau, Micronesia possess characters thought to be taxonomically primitive for the genus Homo.
  59. ncbi Stereocontrolled synthesis of triazacyclopenta[cd]pentalenes by intramolecular 1,3-dipolar cycloaddition reactions of azomethine imines
    Guillaume Bélanger
    Department of Chemistry, 516 Rowland Hall, University of California, Irvine, California 92697 2025
    J Org Chem 67:7880-3. 2002
    ..further as a potential central strategic step in the total syntheses of complex guanidine alkaloids such as palau'amine and styloguanidine...
  60. pmc Paltolides A--C, anabaenopeptin-type peptides from the palau sponge Theonella swinhoei
    Alberto Plaza
    Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0820, USA
    J Nat Prod 73:485-8. 2010
    ..named paltolides A-C, were isolated from a deep-water specimen of the marine sponge Theonella swinhoei from Palau. Paltolides belong to a rare subgroup of sponge-derived anabaenopeptins that have in common a C-terminal ..
  61. ncbi Peripatric differentiation among adjacent marine lake and lagoon populations of a coastal fish, Sphaeramia orbicularis (Apogonidae, Perciformes, Teleostei)
    Ryo O Gotoh
    Graduate School of Science and Engineering, Yamagata University, Yamagata 990 8560, Japan
    Genes Genet Syst 84:287-95. 2009
    ..Focusing on marine lakes of the Palau Islands, we investigated the effect of geographical isolation on Sphaeramia orbicularis, a coastal fish inhabiting ..
  62. ncbi P50 sensory gating in multiplex schizophrenia families from a Pacific island isolate
    Marina Myles-Worsley
    Department of Psychiatry, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132, USA
    Am J Psychiatry 159:2007-12. 2002
    Multiplex schizophrenia families from Palau, Micronesia, were assessed with P50 sensory gating to 1) test for replication of the association between this inhibitory neurobiological trait and familial schizophrenia in non-Caucasian ..
  63. pmc Host shift and speciation in a coral-feeding nudibranch
    Anuschka Faucci
    Kewalo Marine Laboratory, University of Hawaii at Manoa, 41 Ahui Street, Honolulu, HI 96813, USA
    Proc Biol Sci 274:111-9. 2007
    ..of host specificity in the speciation of the nudibranch genus Phestilla (Gastropoda, Opisthobranchia) from Guam, Palau and Hawaii...
  64. ncbi Ruegeria mobilis sp. nov., a member of the Alphaproteobacteria isolated in Japan and Palau
    Yuki Muramatsu
    Biological Resource Center NBRC, Department of Biotechnology, National Institute of Technology and Evaluation, Kisarazu, Chiba 292 0818, Japan
    Int J Syst Evol Microbiol 57:1304-9. 2007
    ..positions of two bacterial strains, MBIC01146(T) and MBIC01099, isolated from marine environments of Japan and Palau, respectively, were determined by using a polyphasic approach...
  65. ncbi Cancer in Micronesia
    Neal A Palafox
    Department of Family Medicine and Community Health, John A Burns School of Medicine, University of Hawaii, Honolulu, HI, USA
    Pac Health Dialog 11:78-83. 2004
    ..Kosrae, Pohnpei, and Yap (the four states of the Federated States of Micronesia), as well as the Republic of Palau (Belau), the Republic of Kiribati, the Republic of the Marshall Islands (RMI), and the Republic of Nauru to review ..
  66. ncbi The use of appropriateness criteria for the selection of clinical preventive services for a Pacific island health service
    A M Durand
    Yap State, Dept of Health Services and Yap Area Health Education Center
    Pac Health Dialog 12:141-4. 2005
    ..The general practice/public health physician residency class of the Palau Area Health Education Center reviewed existing clinical preventive services protocols for the Ministry of Health ..
  67. doi River discharge reduces reef coral diversity in Palau
    Yimnang Golbuu
    Palau International Coral Reef Center, 1 M Dock Road, P O Box 7086, Koror 96940, Palau
    Mar Pollut Bull 62:824-31. 2011
    ..Land development very often leads to increases in river runoff and suspended solids concentrations that reduce coral cover and coral diversity on adjacent reefs...
  68. pmc Novel N-methylated 8-oxoisoguanines from Pacific sponges with diverse neuroactivities
    Tsuyoshi Sakurada
    Faculty of Fisheries Sciences, Hokkaido University, Hakodate 041 8611, Japan
    J Med Chem 53:6089-99. 2010
    ..of four novel, neurologically active purines 1-4, isolated from Haplosclerida sponges collected in the Republic of Palau. The structures were determined by analyses of spectral and X-ray data...
  69. pmc Evaluation of pyridoacridine alkaloids in a zebrafish phenotypic assay
    Xiaomei Wei
    Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA
    Mar Drugs 8:1769-78. 2010
    ..carbonaria, collected in Palau. Structures were assigned on the basis of extensive 1D and 2D NMR studies as well as analysis by HRESIMS...
  70. pmc Toward Palau'amine: Hg(OTf)(2)-Catalyzed Synthesis of the Cyclopentane Core
    Kosuke Namba
    Division of Chemistry, Hokkaido University, Kita ku, Sapporo 060 0810 Japan, Fax 81 11 706 2703
    Chemistry 15:6560-3. 2009
    ..The subsequent eight steps gave the functionalized cyclopentane with the correct stereochemistry that corresponds to the E ring of palau'amine (see scheme).
  71. ncbi Identity and diversity of coral endosymbionts (zooxanthellae) from three Palauan reefs with contrasting bleaching, temperature and shading histories
    K E Fabricius
    Australian Institute of Marine Science, PMB No 3, Townsville MC, Qld 4810, Australia
    Mol Ecol 13:2445-58. 2004
    ..three reefs with contrasting histories of bleaching mortality, water temperature and shading, in the Republic of Palau (Micronesia)...
  72. pmc Rapid evolutionary radiation of marine zooplankton in peripheral environments
    Michael N Dawson
    Biological, Earth, and Environmental Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia
    Proc Natl Acad Sci U S A 102:9235-40. 2005
    ..Marine lakes present situations rare in their clarity for studying evolution in marine taxa...
  73. ncbi Perexilibacter aurantiacus gen. nov., sp. nov., a novel member of the family 'Flammeovirgaceae' isolated from sediment
    Jaewoo Yoon
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Int J Syst Evol Microbiol 57:964-8. 2007
    ..rod-shaped bacterium, designated strain Shu-F-UV2-2(T), was isolated from sediment (Carp Island, Republic of Palau) and was the focus of a polyphasic taxonomic study...
  74. ncbi Endemic hepatitis B virus infection and chronic liver disease mortality in the Republic of Palau, 1990-2002
    Tara M Vogt
    Division of Viral Hepatitis, Centers for Disease Control and Prevention, MS G37, Atlanta, GA 30333, USA
    Trans R Soc Trop Med Hyg 100:1130-4. 2006
    In the Republic of Palau, a Pacific island nation, approximately 20% of the population is chronically infected with hepatitis B virus (HBV) and is at risk of developing chronic liver disease (CLD), including cirrhosis and hepatocellular ..
  75. ncbi Single nucleotide polymorphism and lifestyle-related diseases in the Asia-Pacific region: comparative study in Okinawa, Palau and Thailand
    Y Kagawa
    High Technology Centre, Department of Medical Chemistry and Nutrition Clinic, Kagawa Nutrition University, Chiyoda Sakado, Saitama 350 0288, Japan
    Asia Pac J Public Health 15:S10-4. 2003
    ..chronic disease risk factors in age-matched and population-based groups in four Asian-Pacific locations: Okinawa, Palau and Thailand (two areas). The following allelic SNP profiles significantly differed (p<0...
  76. doi Familial transmission of schizophrenia in Palau: A 20-year genetic epidemiological study in three generations
    Marina Myles-Worsley
    Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, New York, USA
    Am J Med Genet B Neuropsychiatr Genet 156:247-54. 2011
    ..genetic epidemiological studies of schizophrenia and other psychotic disorders (SCZ) in the isolated population of Palau have been ongoing for 20 years...
  77. ncbi The Palau Early Psychosis Study: neurocognitive functioning in high-risk adolescents
    Marina Myles-Worsley
    Department of Psychiatry, SUNY Upstate Medical University, Syracuse NY 13210, USA
    Schizophr Res 89:299-307. 2007
    ....
  78. ncbi Public health in the Republic of Palau: what we can learn from a small island country
    Timothy S Duerler
    Department of Family Medicine and Community Health, John A Burns School of Medicine, University of Hawai i a t Manoa, Mililani, Hawai i 96789 1192, USA
    Pac Health Dialog 14:182-7. 2007
    The Republic of Palau has a well-run public health system despite being a small, relatively isolated island country with limited resources and limited funds...
  79. pmc Cryptic diversity, molecular phylogeny and biogeography of the rock- and leaf litter-dwelling land snails of Belau (Republic of Palau, Oceania)
    Rebecca J Rundell
    Committee on Evolutionary Biology, University of Chicago, 1025 East 57th Street, Chicago, IL 60637, USA
    Philos Trans R Soc Lond B Biol Sci 363:3401-12. 2008
    The endemic diplommatinid land snails (Caenogastropoda: Mollusca) of Belau (Republic of Palau, Micronesia) are an exceptionally diverse group of largely undescribed species distributed among rock and leaf litter habitats on most of Belau'..
  80. ncbi The early childhood caries prevention program in Palau
    A Keith Larson
    Division of Oral Health, Ministry of Health, Koror, Palau
    Pac Health Dialog 10:106-10. 2003
    Early Childhood Caries is a significant public health problem in Palau. Data have shown that nearly 80% of children ages 3-5 years of age in Palau experience dental caries and a significant number of these children require general ..
  81. ncbi Enrichment of excess 210Po in anoxic ponds
    Guebuem Kim
    School of Earth and Environmental Sciences RIO, College of Natural Sciences, Seoul National University, Seoul 151 742, Korea
    Environ Sci Technol 39:4894-9. 2005
    ..occurring 210Po in waters from seasonally anoxic Pond B (South Carolina) and permanently anoxic Jellyfish Lake (Palau Islands, western Pacific Ocean). The maximum 210Po activity in Pond B was about 14 mBq L(-1) during summer...
  82. ncbi The pursuit of palau'amine
    Matthias Köck
    Alfred Wegener Institut für Polar und Meeresforschung in der Helmholtz Gemeinschaft, Am Handelshafen 12, 27570 Bremerhaven, Germany
    Angew Chem Int Ed Engl 46:6586-94. 2007
    Since its discovery in 1993, the marine natural product palau'amine has intrigued natural product chemists. Its exotic molecular architecture and purported bioactivity made it an ideal target for synthesis...
  83. ncbi Janibacter corallicola sp. nov., isolated from coral in Palau
    Akiko Kageyama
    Kitasato Institute for Life Sciences, Kitasato University, Minato ku, Tokyo, Japan
    J Gen Appl Microbiol 53:185-9. 2007
    ..Two bacterial strains were isolated in Palau, which were both Gram-positive, catalase-positive bacteria with meso-diaminopimelic acid as the diagnostic diamino ..
  84. doi Facile synthesis of the trans-fused azabicyclo[3.3.0]octane core of the palau'amines and the tricyclic core of the axinellamines from a common intermediate
    Manuel A Zancanella
    Department of Chemistry, Texas A and M University, P O Box 30012, College Station, Texas 77842 3012, USA
    Org Lett 10:3685-8. 2008
    A facile synthesis of the trans-fused azabicyclo[3.3.0]octane core of palau'amine and related pyrrole-imidazole alkaloids is described...
  85. pmc On the structure of palau'amine: evidence for the revised relative configuration from chemical synthesis
    Brian A Lanman
    Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, CA 92697 2025, USA
    J Am Chem Soc 129:12896-900. 2007
    Hexacyclic congeners 3 and 4 of palau'amine, which incorporate both guanidine functional groups and have the cis configuration of the azabicyclo[3.3.0]octane core, are prepared in 14 steps from cycloadduct 6...
  86. doi Limibacter armeniacum gen. nov., sp. nov., a novel representative of the family 'Flammeovirgaceae' isolated from marine sediment
    Jaewoo Yoon
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Int J Syst Evol Microbiol 58:982-6. 2008
    ..rod-shaped bacteria, strains YM11-185T and YM11-159, were isolated from marine sediments in the Republic of Palau. Preliminary analysis based on the 16S rRNA gene sequence revealed that the novel isolates could be affiliated ..
  87. ncbi Pilot workshops at the Palau Center for Emergency Health: a model for international collaborative operations training and planning
    Karen Cleveland
    Emergency Preparedness and Response Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341 3724, USA
    Pac Health Dialog 9:7-10. 2002
    ..Lectures presented in both workshops are now available in the public domain. They can be used to improve regional public health emergency capabilities whether the region considered is local, state, or international...
  88. pmc Exploring symmetry-based logic for a synthesis of palau'amine
    Qingyi Li
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9038, USA
    J Org Chem 74:5909-19. 2009
    A synthetic approach to palau'amine is described that exploits veiled symmetry in the structure. Bis-alkylidenes i have been prepared and found susceptible to halogenative desymmetrization using t-BuOCl...
  89. doi Water flow drives biodiversity by mediating rarity in marine benthic communities
    James E Palardy
    Department of Ecology and Evolutionary Biology, 80 Waterman Street, Box G W, Brown University, Providence, RI 02912, USA
    Ecol Lett 14:63-8. 2011
    ..In Palau and Alaska, flow velocity predicted 55-91% of the variance in species richness in natural communities...
  90. ncbi Stamp vignette on medical science. Marshall W. Nirenberg--Nobel Laureate in Physiology or Medicine
    Marc A Shampo
    Mayo Clin Proc 79:448. 2004
  91. ncbi JABSOM's legacy in the Pacific: linking the PBMOTP and Pacific Basin AHEC Programs--a Palau perspective
    Greg Dever
    Pac Health Dialog 12:6-10. 2005
  92. pmc Distribution of genome-wide linkage disequilibrium based on microsatellite loci in the Samoan population
    Hui Ju Tsai
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Hum Genomics 1:327-34. 2004
    ..The patterns of LD observed in the Samoan population are quite similar to those previously observed in Palau but markedly contrast with those observed in a non-isolated Caucasian sample, where there is essentially no marker-..
  93. ncbi Frederick Sanger--winner of 2 Nobel prizes
    Marc A Shampo
    Mayo Clin Proc 77:212. 2002
  94. ncbi Palau's current and future capacity for disaster management
    David Rykken
    Hospital Preparedness Program, Ministry of Health, Koror, Republic of Palau
    Pac Health Dialog 12:99-104. 2005
    Despite the challenges of geographic isolation, a small population and limited financial resources, the Republic of Palau has been able to significantly improve its ability to address disasters through establishing an emergency health ..
  95. ncbi Era of globalization, emerging and re-emerging diseases and the increasing burden of non-communicable diseases
    Stevenson Kuartei
    Pac Health Dialog 12:5. 2005
  96. ncbi Cancer in the Republic of Palau (Belau)
    Vanessa Wong
    Department of Family Medicine and Community Health, John A Burns School of Medicine, University of Hawai i, USA
    Pac Health Dialog 11:64-9. 2004
    ..Key informants requested help to develop a comprehensive cancer prevention and control program, increase the capacity of professional staff in diagnosing and treating cancer, and improve laboratory and pathology services...
  97. ncbi Walter Gilbert--1980 Nobel Prize for Chemistry
    Marc A Shampo
    Mayo Clin Proc 78:588. 2003
  98. ncbi Incest in Palau: "Delemumuu undressed"
    Stevenson Kuartei
    Ministry of Health, Republic of Palau
    Pac Health Dialog 12:84-91. 2005
    ..will attempt to lay out the cultural framework from which incest is defined, summarize actual cases of incest in Palau and finally discuss some future actions needed to clarify the definition as well as, detailing the "burden" of ..
  99. doi Whole-island carbon stocks in the tropical Pacific: implications for mangrove conservation and upland restoration
    D C Donato
    USDA Forest Service, Pacific Southwest Research Station, Institute of Pacific Islands Forestry, Hilo, HI 96720, USA
    J Environ Manage 97:89-96. 2012
    ..On two island groups of Micronesia (Yap and Palau), we sampled all above- and belowground C pools, including soil and vegetation, in 24 sites distributed evenly ..
  100. pmc Palau'amine and related oroidin alkaloids dibromophakellin and dibromophakellstatin inhibit the human 20S proteasome
    Theresa A Lansdell
    Department of Chemistry, Michigan State University, East Lansing, Michigan 48823, USA
    J Nat Prod 75:980-5. 2012
    We report herein that the oroidin-derived alkaloids palau'amine (1), dibromophakellin (2), and dibromophakellstatin (3) inhibit the proteolytic activity of the human 20S proteasome as well as the (i)20S immunoproteasome catalytic core...
  101. doi Mild construction of 3-methyl tetramic acids enabling a formal synthesis of palau'imide
    Wen Ju Bai
    Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA
    Org Lett 14:3862-5. 2012
    ..The synthetic sequence employs a SmI(2)-mediated cyclization, whereby the chirality of the emerging tetramic acid core is retained from the starting chiral amino acid. Application to palau'imide is discussed.

Research Grants71

  1. Approaches to Bioactive Aminoimidazole Natural Products
    CARL LOVELY; Fiscal Year: 2007
    ..g., ageliferin), which possess antibacterial properties, and the more complex palau'amine and related targets, konbu'acidin A, styloguanidine and axinellamine A...
  2. PRACTICAL CHEMICAL SYNTHESIS OF COMPLEX ALKALOIDS
    LARRY OVERMAN; Fiscal Year: 2009
    ..Total synthesis investigations will be carried out in four structurally distinct areas: hetisine alkaloids, palau'amine and congeners, massadine and sarain A...
  3. PRACTICAL CHEMICAL SYNTHESIS OF COMPLEX ALKALOIDS
    LARRY OVERMAN; Fiscal Year: 2007
    ..Total synthesis investigations will be carried out in four structurally distinct areas: hetisine alkaloids, palau'amine and congeners, massadine and sarain A...
  4. SYNTHETIC/MECHANISTIC STUDIES OF BIOACTIVE MARINE AGENTS
    Daniel Romo; Fiscal Year: 2004
    ..of the proposal include total synthesis and biomechanistic studies of the marine natural products pateamine A, palau'amine, gymnodimine, and phakellin which possess novel structures and exhibit potent physiological effects...
  5. Synthesis of Bioactive Complex Alkaloids
    David Y Gin; Fiscal Year: 2010
    ..disrupting crambescidin alkaloids, the potent cytotoxin cylindrospermopsin, and the powerful immunosuppressant palau'amine...
  6. SYNTHETIC/MECHANISTIC STUDIES OF BIOACTIVE MARINE AGENTS
    Daniel Romo; Fiscal Year: 2007
    ..this renewal proposal include synthetic and biomechanistic studies of the marine natural products axinellamine A, palau'amine, gymnodimine, phakellstatin, pateamine A and thiolyngbyan, which possess novel structure and exhibit potent ..
  7. SYNTHESES OF BIOLOGICALLY ACTIVE MARINE ALKALOIDS
    David Horne; Fiscal Year: 2001
    ..oroidin alkaloids, dibromoagelaspongin and agelastatin, the dimeric oroidin alkaloids ageliferin, sceptrin, and palau amine, the potent neurotoxins saxitoxin and gonyautoxins...
  8. Synthesis of Bioactive Complex Alkaloids
    DAVID GIN; Fiscal Year: 2007
    ..disrupting crambescidin alkaloids, the potent cytotoxin cylindrospermopsin, and the powerful immunosuppressant palau'amine...
  9. Synthesis of Amino Acid-Containing Natural Products
    Robert Williams; Fiscal Year: 2009
    ..azomethine ylid dipolar cycloaddition reactions for application to the asymmetric total synthesis of palau'amine and congeners; (3) diastereoselective aldol and lactone functionalization methods for application to a ..
  10. Synthesis of Amino Acid-Containing Natural Products
    Robert Michael Williams; Fiscal Year: 2010
    ..azomethine ylid dipolar cycloaddition reactions for application to the asymmetric total synthesis of palau'amine and congeners;(3) diastereoselective aldol and lactone functionalization methods for application to a ..
  11. PRACTICAL CHEMICAL SYNTHESIS OF COMPLEX ALKALOIDS
    LARRY OVERMAN; Fiscal Year: 2002
    ..alkaloids, which inhibit protein-protein interactions tha are important for immunological responses, (c) palau'amine, a relatively non-toxic immunomodulator, (d) styloguanidine, a chitinase inhibitor, and (e) aloperine, an ..
  12. Synthesis of Bioactive Complex Alkaloids
    DAVID GIN; Fiscal Year: 2009
    ..disrupting crambescidin alkaloids, the potent cytotoxin cylindrospermopsin, and the powerful immunosuppressant palau'amine...
  13. Strategies and Methods for Complex Alkaloid Synthesis
    Erik Sorensen; Fiscal Year: 2007
    ..chloroaminations of alkenes for use in a total synthesis of the potent immunosuppressive and cytotoxic alkaloid palau'amine...
  14. Synthesis and Properties of Nitrogen-Rich Polycycles
    Patrick Harran; Fiscal Year: 2007
    ..is synthesized via an oxidationinitiated cyclization event and this theme is also present in studies proposed for palau'amine and its relatives...
  15. Synthesis of Pyrrole-Imidazole Alkaloids
    Phil Baran; Fiscal Year: 2007
    ..syntheses of sceptrin, oxysceptrin, nakamuric acid, ageliferin, nagelamide, axinellamine, massadine, and palau'amine are proposed...
  16. Synthesis of Pyrrole-Imidazole Alkaloids
    Phil Baran; Fiscal Year: 2007
    ..syntheses of sceptrin, oxysceptrin, nakamuric acid, ageliferin, nagelamide, axinellamine, massadine, and palau'amine are proposed...
  17. Synthesis of Pyrrole-Imidazole Alkaloids
    Phil Baran; Fiscal Year: 2009
    ..syntheses of sceptrin, oxysceptrin, nakamuric acid, ageliferin, nagelamide, axinellamine, massadine, and palau'amine are proposed...
  18. Genetics of Schizophrenia in Oceanic Palau
    William Byerley; Fiscal Year: 2009
    ..liability to schizophrenia and other psychotic disorders (henceforth called Scz) in the Oceanic population of Palau. We will accomplish this goal by capitalizing on a wide range of scientific expertise and an incredible population ..
  19. Synthesis of 2-Aminoimidazole-Based Alkaloids
    David Horne; Fiscal Year: 2007
    ..In particular, we plan to synthesize sceptrin (4), dibromoagelaspongin (6), ageliferin (7), palau'amine (9), agelastatin D (12), and axinellamine (14)...
  20. Genetics of Schizophrenia in Oceanic Palau
    William Byerley; Fiscal Year: 2007
    ..liability to schizophrenia and other psychotic disorders (henceforth called Scz) in the Oceanic population of Palau. We will accomplish this goal by capitalizing on a wide range of scientific expertise and an incredible population ..
  21. Admixture Mapping Schizophrenia Genes in Oceanic Palau
    William Byerley; Fiscal Year: 2006
    ..Its presentation and course are no different in the Remote Oceanic population of Palau, but the population structure of Palau presents unique opportunities to explore the genetic etiology of this ..
  22. Synthesis of Amino Acid-Containing Natural Products
    Robert Williams; Fiscal Year: 2007
    ..azomethine ylid dipolar cycloaddition reactions for application to the asymmetric total synthesis of palau'amine; (3) diastereoselective aldol and lactone functionalization methods for application to a short, asymmetric ..