Summary: The presence of four sets of chromosomes. It is associated with ABNORMALITIES, MULTIPLE; and MISCARRAGES.

Top Publications

  1. Krasileva K, Buffalo V, Bailey P, Pearce S, Ayling S, Tabbita F, et al. Separating homeologs by phasing in the tetraploid wheat transcriptome. Genome Biol. 2013;14:R66 pubmed publisher
    ..The predicted tetraploid wheat proteome and gene models provide a valuable tool for the wheat research community and for those interested in comparative genomic studies. ..
  2. Wang J, Huo B, Liu W, Li D, Liao L. Abnormal meiosis in an intersectional allotriploid of Populus L. and segregation of ploidy levels in 2x × 3x progeny. PLoS ONE. 2017;12:e0181767 pubmed publisher
    ..Individuals with different chromosome compositions are potential to analyze chromosomal function and to integrate the chromosomal dosage variation into breeding programs of Populus. ..
  3. Proctor L, Pradhan M, Leung S, Cheng A, Lee C, Soslow R, et al. Assessment of DNA Ploidy in the ProMisE molecular subgroups of endometrial cancer. Gynecol Oncol. 2017;146:596-602 pubmed publisher
    ..The addition of ploidy to the ProMisE molecular categories conferred additional prognostic value within the MMR-D group, which merits further study. ..
  4. Majka J, Ksiazczyk T, Kiełbowicz Matuk A, Kopecky D, Kosmala A. Exploiting repetitive sequences and BAC clones in Festuca pratensis karyotyping. PLoS ONE. 2017;12:e0179043 pubmed publisher
    ..The last group was exploited to develop cytogenetic maps of diploid and tetraploid F. pratensis, which are presented here for the first time and provide a remarkable progress in karyotype characterization. ..
  5. Matsuda R, Iehisa J, Sakaguchi K, Ohno R, Yoshida K, Takumi S. Global gene expression profiling related to temperature-sensitive growth abnormalities in interspecific crosses between tetraploid wheat and Aegilops tauschii. PLoS ONE. 2017;12:e0176497 pubmed publisher
    ..Dramatic alteration of gene expression profiles, including miRNA levels, in crown tissues is associated with the temperature-dependent phenotypic plasticity in type II necrosis/grass-clump dwarf wheat hybrids. ..
  6. Xu Z, Liu J, Ni W, Peng Z, Guo Y, Ye W, et al. GrTEdb: the first web-based database of transposable elements in cotton (Gossypium raimondii). Database (Oxford). 2017;2017: pubmed publisher
    ..http://www.grtedb.org/. ..
  7. Lundström M, Leino M, Hagenblad J. Evolutionary history of the NAM-B1 gene in wild and domesticated tetraploid wheat. BMC Genet. 2017;18:118 pubmed publisher
    ..Further studies of genotype-environment interactions are needed to find out under what conditions selection on different NAM-B1 alleles have been beneficial. ..
  8. Tan F, Tu H, Liang W, Long J, Wu X, Zhang H, et al. Comparative metabolic and transcriptional analysis of a doubled diploid and its diploid citrus rootstock (C. junos cv. Ziyang xiangcheng) suggests its potential value for stress resistance improvement. BMC Plant Biol. 2015;15:89 pubmed publisher
    ..Compared to diploid, higher expression level of stress related genes and higher content of stress related metabolites in doubled diploid could be beneficial for its stress tolerance. ..
  9. Knytl M, Smolík O, Kubickova S, Tlapakova T, Evans B, Krylov V. Chromosome divergence during evolution of the tetraploid clawed frogs, Xenopus mellotropicalis and Xenopus epitropicalis as revealed by Zoo-FISH. PLoS ONE. 2017;12:e0177087 pubmed publisher
    ..These results are consistent with a dynamic history of genomic rearrangements before and/or after genome duplication, a surprising finding given the otherwise relatively conserved genomic structure of most frogs. ..

More Information


  1. Kang L, Wu T, Tao Y, Yuan Y, He J, Zhang Y, et al. Viable mice produced from three-factor induced pluripotent stem (iPS) cells through tetraploid complementation. Cell Res. 2011;21:546-9 pubmed publisher
  2. Liu H, Sun B, Wang S, Liu C, Lu Y, Li D, et al. Circulating Tumor Cells as a Biomarker in Pancreatic Ductal Adenocarcinoma. Cell Physiol Biochem. 2017;42:373-382 pubmed publisher
    ..4% at a cutoff point of 2 CTC subtypes. The diagnostic value of both total CTC number and CTC subtype number was a little poorer than CA199. Both CTC subtype and total CTC number may serve as potential biomarkers for PDAC. ..
  3. Ahmed M, Shen C, Khan A, Wahid M, Shaban M, Lin Z. A comparative genomics approach revealed evolutionary dynamics of microsatellite imperfection and conservation in genus Gossypium. Hereditas. 2017;154:12 pubmed publisher
    ..The outcome could be a directive to explore comparative evolutionary footprints of simple non-coding genetic elements i.e., repeat elements, through the evolution of genus-specific characteristics in cotton genomes. ..
  4. Yu F, Wang H, Zhao Y, Liu R, Dou Q, Dong J, et al. Karyotypic evolution of the Medicago complex: sativa-caerulea-falcata inferred from comparative cytogenetic analysis. BMC Evol Biol. 2017;17:104 pubmed publisher
    ..However, the tetraploid subspecies falcata is far from a simple autopolyploid from diploid subspecies falcata although no obvious morphological change was observed between these two subspecies. ..
  5. Wang N, Ma J, Pei W, Wu M, Li H, Li X, et al. A genome-wide analysis of the lysophosphatidate acyltransferase (LPAAT) gene family in cotton: organization, expression, sequence variation, and association with seed oil content and fiber quality. BMC Genomics. 2017;18:218 pubmed publisher
  6. Li X, Shahid M, Xia J, Lu Z, Fang N, Wang L, et al. Analysis of small RNAs revealed differential expressions during pollen and embryo sac development in autotetraploid rice. BMC Genomics. 2017;18:129 pubmed publisher
    ..Together, these findings provide a foundation for understanding the effect of polyploidy on small RNAs expression patterns during pollen and embryo sac development that may lead to different abnormalities in autotetraploid rice. ..
  7. Cao X. Whole genome sequencing of cotton--a new chapter in cotton genomics. Sci China Life Sci. 2015;58:515-6 pubmed publisher
  8. Ranwez V, Holtz Y, Sarah G, Ardisson M, Santoni S, Glemin S, et al. Disentangling homeologous contigs in allo-tetraploid assembly: application to durum wheat. BMC Bioinformatics. 2013;14 Suppl 15:S15 pubmed publisher
    ..supagro.inra.fr/homeoSplitter/. This work provides a practical solution to the complex problem of disentangling homeologous transcripts in allo-tetraploids, which further allows an improved SNP detection. ..
  9. Laidò G, Mangini G, Taranto F, Gadaleta A, Blanco A, Cattivelli L, et al. Genetic Diversity and Population Structure of Tetraploid Wheats (Triticum turgidum L.) Estimated by SSR, DArT and Pedigree Data. PLoS ONE. 2013;8:e67280 pubmed publisher
    ..subspecies and the genetic potential of landraces and wild accessions for the detection of unexplored alleles. ..
  10. Wang T, Uauy C, Till B, Liu C. TILLING and associated technologies. J Integr Plant Biol. 2010;52:1027-30 pubmed publisher
  11. Shen C, Jin X, Zhu D, Lin Z. Uncovering SNP and indel variations of tetraploid cottons by SLAF-seq. BMC Genomics. 2017;18:247 pubmed publisher
    ..The results presented herein provide a valuable genomic resource for new insights into the genetics and breeding of cotton. ..
  12. Nakayama Y, Soeda S, Ikeuchi M, Kakae K, Yamaguchi N. Cytokinesis Failure Leading to Chromosome Instability in v-Src-Induced Oncogenesis. Int J Mol Sci. 2017;18: pubmed publisher
    ..review, we highlight recent progress in our understanding of cytokinesis failure and the attenuation of the tetraploidy checkpoint in v-Src-expressing cells...
  13. Banjanac T, Dragićević M, Siler B, Gašić U, Bohanec B, Nestorović Živković J, et al. Chemodiversity of two closely related tetraploid Centaurium species and their hexaploid hybrid: Metabolomic search for high-resolution taxonomic classifiers. Phytochemistry. 2017;140:27-44 pubmed publisher
    ..The presented metabolomics approach will certainly, along with morphometrics and molecular genetics studies, have high impact on further elucidation of complex relationships among taxa within the genus Centaurium. ..
  14. Quan J, Meng S, Guo E, Zhang S, Zhao Z, Yang X. De novo sequencing and comparative transcriptome analysis of adventitious root development induced by exogenous indole-3-butyric acid in cuttings of tetraploid black locust. BMC Genomics. 2017;18:179 pubmed publisher
  15. Donze Reiner T, Palmer N, Scully E, Prochaska T, Koch K, Heng Moss T, et al. Transcriptional analysis of defense mechanisms in upland tetraploid switchgrass to greenbugs. BMC Plant Biol. 2017;17:46 pubmed publisher
    ..These results can be exploited to develop switchgrass lines with more durable resistance to GB and potentially other aphids. ..
  16. Patiño Parrado I, Gómez Jiménez Á, López Sánchez N, Frade J. Strand-specific CpG hemimethylation, a novel epigenetic modification functional for genomic imprinting. Nucleic Acids Res. 2017;45:8822-8834 pubmed publisher
    ..We anticipate the existence of a novel molecular mechanism regulating the transition from fully methylated CpGs to strand-specific hemimethylated CpGs. ..
  17. Sulli M, Mandolino G, Sturaro M, Onofri C, Diretto G, Parisi B, et al. Molecular and biochemical characterization of a potato collection with contrasting tuber carotenoid content. PLoS ONE. 2017;12:e0184143 pubmed publisher
    ..Other tuber metabolites, such as glucose, monogalactosyldiacyglycerol (a glycolipid), or suberin precursors, showed instead significant correlations with both traits. ..
  18. Fang L, Gong H, Hu Y, Liu C, Zhou B, Huang T, et al. Genomic insights into divergence and dual domestication of cultivated allotetraploid cottons. Genome Biol. 2017;18:33 pubmed publisher
    ..hirsutum and G. barbadense and between wild accessions and modern cultivars. These results provide genomic bases for improving cotton production and for further evolution analysis of polyploid crops. ..
  19. Deng M, Dong Y, Zhao Z, Li Y, Fan G. Dissecting the proteome dynamics of the salt stress induced changes in the leaf of diploid and autotetraploid Paulownia fortunei. PLoS ONE. 2017;12:e0181937 pubmed publisher
    ..This study offers a better understanding of the mechanisms of salt tolerance in P. fortunei and provides a list of potential target genes that could be engineered for salt acclimation in plants, especially trees. ..
  20. Ye L, Zhang C, Tang X, Chen Y, Liu S. Variations in 5S rDNAs in diploid and tetraploid offspring of red crucian carp × common carp. BMC Genet. 2017;18:75 pubmed publisher
    ..This study provided new insights into the relationship among the evolution of 5S rDNAs, hybridization and polyploidization, which were significant in clarifying the genome evolution of polyploid fish. ..