maternal inheritance


Summary: Transmission of genetic characters, qualities, and traits, solely from maternal extra-nuclear elements such as MITOCHONDRIAL DNA or MATERNAL MESSENGER RNA.

Top Publications

  1. Wagner G, Singhal N, Nicetto D, Straub T, Kremmer E, Rupp R. Brg1 chromatin remodeling ATPase balances germ layer patterning by amplifying the transcriptional burst at midblastula transition. PLoS Genet. 2017;13:e1006757 pubmed publisher
    ..Since this group contains many key developmental regulators, we propose Brg1 to be responsible for raising their expression above threshold levels in preparation for embryonic patterning. ..
  2. Hillman P, Christian S, Doan R, Cohen N, Konganti K, Douglas K, et al. Genomic imprinting does not reduce the dosage of UBE3A in neurons. Epigenetics Chromatin. 2017;10:27 pubmed publisher
    ..Based on our findings, we propose that imprinting of UBE3A does not function to reduce the dosage of UBE3A in neurons but rather to regulate some other, as yet unknown, aspect of gene expression or protein function. ..
  3. Hong W, Zheng B, Qian J, Wu H, Jin H, Zhu Y. [Modification factors associated with maternally inherited non-syndromic hearing loss]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017;52:472-477 pubmed publisher
  4. Sato K, Sato M. Multiple ways to prevent transmission of paternal mitochondrial DNA for maternal inheritance in animals. J Biochem. 2017;162:247-253 pubmed publisher
    ..mechanisms to prevent the transmission of sperm-derived paternal mtDNA to the offspring, thereby ensuring maternal inheritance of mtDNA...
  5. Carmona Antoñanzas G, Bekaert M, Humble J, Boyd S, Roy W, Bassett D, et al. Maternal inheritance of deltamethrin resistance in the salmon louse Lepeophtheirus salmonis (Krøyer) is associated with unique mtDNA haplotypes. PLoS ONE. 2017;12:e0180625 pubmed publisher
    ..26 ?g L-1. The results revealed a predominantly maternal inheritance of deltamethrin resistance...
  6. Lopes F, Ferreira J, Lobo R, Rosa G. Bayesian analyses of genetic parameters for growth traits in Nellore cattle raised on pasture. Genet Mol Res. 2017;16: pubmed publisher
  7. Zhou M, Wang M, Xue L, Lin Z, He Q, Shi W, et al. A hypertension-associated mitochondrial DNA mutation alters the tertiary interaction and function of tRNALeu(UUR). J Biol Chem. 2017;292:13934-13946 pubmed publisher
    ..In conclusion, our findings may provide new insights into the pathophysiology of maternally inherited hypertension. ..
  8. Brici D, Zhang Q, Reinhardt S, Dahl A, Hartmann H, Schmidt K, et al. Setd1b, encoding a histone 3 lysine 4 methyltransferase, is a maternal effect gene required for the oogenic gene expression program. Development. 2017;144:2606-2617 pubmed publisher
    ..Together, these findings indicate that Setd1b serves as maternal effect gene through regulation of the oocyte gene expression program. ..
  9. Cavero T, Rabasco C, Molero A, Blázquez A, Hernández E, Martín M, et al. When should a nephrologist suspect a mitochondrial disease?. Nefrologia. 2015;35:6-17 pubmed publisher
    ..Specific treatments do not exist for the majority of mitochondrial diseases, but it is likely that the intense research that currently exists for these diseases will eventually produce effective treatment possibilities. ..

More Information


  1. Srirattana K, McCosker K, Schatz T, St John J. Cattle phenotypes can disguise their maternal ancestry. BMC Genet. 2017;18:59 pubmed publisher
    ..The phenotype of cattle is not always related to their mtDNA profiles. MtDNA profiles should be considered for breeding programmes as they also influence phenotypic traits and reproductive capacity in terms of oocyte quality. ..
  2. Pereira G, Pinho R, Pinho E, Pires L, Bernardo Junior L, Pereira J, et al. Selection of maize inbred lines and gene expression for resistance to ear rot. Genet Mol Res. 2017;16: pubmed publisher
    ..Thus, the genes LOX8 and Hsp82 are potential molecular markers for selection of maize inbred lines resistant to F. verticillioides. ..
  3. Flyamer I, Gassler J, Imakaev M, Brandão H, Ulianov S, Abdennur N, et al. Single-nucleus Hi-C reveals unique chromatin reorganization at oocyte-to-zygote transition. Nature. 2017;544:110-114 pubmed publisher
    ..An understanding of this zygotic chromatin 'ground state' could potentially provide insights into reprogramming cells to a state of totipotency. ..
  4. Mutai H, Watabe T, Kosaki K, Ogawa K, Matsunaga T. Mitochondrial mutations in maternally inherited hearing loss. BMC Med Genet. 2017;18:32 pubmed publisher
    ..3243A?>?G mutation. Since five of nine probands with the clinical criteria used in this study had mtDNA mutations, these criteria may be helpful for identification of candidate patients likely to have mtDNA mutations. ..
  5. Ververi A, Islam L, Bewes B, Busby L, Sullivan C, Canham N. Angelman Syndrome due to a Maternally Inherited Intragenic Deletion Encompassing Exons 7 and 8 of the UBE3A Gene. Cytogenet Genome Res. 2017;152:132-136 pubmed publisher
    ..Alternative techniques, such as array-CGH and MLPA, are necessary when conventional testing for AS has failed to identify the underlying genetic mechanism. ..
  6. Yon D, Park J, Kim S, Shim S, Chae K. A sibship with duplication of Xq28 inherited from the mother; genomic characterization and clinical outcomes. BMC Med Genet. 2017;18:30 pubmed publisher
    ..We tried to analyze the information of the relationship between neuropsychiatric phenotype and the extent of duplication at Xq28 by comparing with previous reports. ..
  7. Zhang J, Liu H, Luo S, Lu Z, Chavez Badiola A, Liu Z, et al. Live birth derived from oocyte spindle transfer to prevent mitochondrial disease. Reprod Biomed Online. 2017;34:361-368 pubmed publisher
    ..36-9.23% in his tested tissues. The boy is currently healthy at 7 months of age, although long-term follow-up of the child's longitudinal development remains crucial. ..
  8. Santos Ferreira D, Williams D, Kangas A, Soininen P, Ala Korpela M, Smith G, et al. Association of pre-pregnancy body mass index with offspring metabolic profile: Analyses of 3 European prospective birth cohorts. PLoS Med. 2017;14:e1002376 pubmed publisher
    ..Our findings suggest that maternal BMI-offspring metabolome associations are likely to be largely due to shared genetic or familial lifestyle confounding rather than to intrauterine mechanisms. ..