bcl 1 genes


Summary: The B-cell leukemia/lymphoma-1 genes, associated with various neoplasms when overexpressed. Overexpression results from the t(11;14) translocation, which is characteristic of mantle zone-derived B-cell lymphomas. The human c-bcl-1 gene is located at 11q13 on the long arm of chromosome 11.

Top Publications

  1. Xiao Z, Chen X, Huang Z. [Inhibitory effect of cyclin D1 antisense cDNA on human hepatocarcinoma cell line HepG2]. Zhonghua Gan Zang Bing Za Zhi. 2005;13:768-71 pubmed
    ..Cyclin D1 antisense cDNA may serve as a potential antitumor strategy in regulating cell-cyclin treating advanced HCCs. ..
  2. Imanishi Y, Kawata T. [Experimental animal models of primary hyperparathyroidism]. Nihon Rinsho. 2005;63 Suppl 10:292-9 pubmed
  3. Hosokawa Y, Suzuki R, Joh T, Maeda Y, Nakamura S, Kodera Y, et al. A small deletion in the 3'-untranslated region of the cyclin D1/PRAD1/bcl-1 oncogene in a patient with chronic lymphocytic leukemia. Int J Cancer. 1998;76:791-6 pubmed
  4. Minko T, Kopeckova P, Kopecek J. Preliminary evaluation of caspases-dependent apoptosis signaling pathways of free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells. J Control Release. 2001;71:227-37 pubmed
    ..It was concluded that HPMA copolymer-bound DOX induced additional caspase-dependent apoptosis signaling pathways and the degree of the induction was higher, which led to more pronounced apoptosis when compared to free DOX. ..
  5. Terrinoni A, Dell Arciprete R, Fornaro M, Stella M, Alberti S. Cyclin D1 gene contains a cryptic promoter that is functional in human cancer cells. Genes Chromosomes Cancer. 2001;31:209-20 pubmed
    ..Thus, this novel CCND1 transcription unit may play a role in the regulation of the expression of cyclin D1 and in tumor cell growth. ..
  6. Yu H, Huang J, Yang Y, Huang H, Luo H, Yu J, et al. The effects of acetylsalicylic acid on proliferation, apoptosis, and invasion of cyclooxygenase-2 negative colon cancer cells. Eur J Clin Invest. 2002;32:838-46 pubmed
    ..Decreased CEA content and CD44v6 expression and elevated nm23 expression may contribute to the effect of ASA on invasive potential of SW480 colon cancer cells. ..
  7. Peng C, Guo W, Yang Y, Zhao H. Downregulation of SS18-SSX1 expression by small interfering RNA inhibits growth and induces apoptosis in human synovial sarcoma cell line HS-SY-II in vitro. Eur J Cancer Prev. 2008;17:392-8 pubmed publisher
    ..Our results demonstrate that siRNA targeting of SS18-SSX1 may have therapeutic potential in the treatment of synovial sarcomas...
  8. Ogino S, Nosho K, Irahara N, Kure S, Shima K, Baba Y, et al. A cohort study of cyclin D1 expression and prognosis in 602 colon cancer cases. Clin Cancer Res. 2009;15:4431-8 pubmed publisher
    ..10-0.65). Cyclin D1 overexpression is associated with longer survival in colon cancer. ..
  9. Sulentic C, Kang J, Na Y, Kaminski N. Interactions at a dioxin responsive element (DRE) and an overlapping kappaB site within the hs4 domain of the 3'alpha immunoglobulin heavy chain enhancer. Toxicology. 2004;200:235-46 pubmed
    ..These results suggest that the AhR nuclear complex and NF-kappaB/Rel proteins converge at the DRE and kappaB motif to influence transcriptional activity of the hs4 enhancer fragment. ..

More Information

Publications104 found, 100 shown here

  1. Jiang J, Wang J, Suzuki S, Gajalakshmi V, Kuriki K, Zhao Y, et al. Elevated risk of colorectal cancer associated with the AA genotype of the cyclin D1 A870G polymorphism in an Indian population. J Cancer Res Clin Oncol. 2006;132:193-9 pubmed
    ..31; 95% CI: 0.18-0.53 for >3 servings/day) and fish intake (OR=0.48; 95% CI: 0.28-0.82). These data support the hypothesis that the CCND1 A870G polymorphism may increase the risk of CRC in our Indian population. ..
  2. Liu H, Huang J, Wang J, Jiang S, Bailey A, Goldman D, et al. Transvection mediated by the translocated cyclin D1 locus in mantle cell lymphoma. J Exp Med. 2008;205:1843-58 pubmed publisher
    ..Furthermore, NPM short hairpin RNA produces a specific growth arrest in these cells. Our data demonstrate transvection in human cancer and suggest a functional role for CTCF and NPM. ..
  3. Donnellan R, Chetty R. Cyclin D1 and human neoplasia. Mol Pathol. 1998;51:1-7 pubmed
    ..Knowledge of cyclin D1's role in malignancy at the various sites, provides a basis on which future treatment directed against this molecule can proceed. ..
  4. Degan M, Doliana R, Gloghini A, Di Francia R, Aldinucci D, Mazzocut Zecchin L, et al. A novel bcl-1/JH breakpoint from a patient affected by mantle cell lymphoma extends the major translocation cluster. J Pathol. 2002;197:256-63 pubmed
    ..The recognition of this novel breakpoint may have important implications for the diagnosis and detection of minimal residual disease in t(11;14)-positive lymphomas. ..
  5. Dimova I, Zaharieva B, Raicheva S, Milev I, Dimitrov R, Doganov N, et al. Association of CyclinD1 copy number changes with histological type in ovarian tumors. Acta Oncol. 2004;43:675-9 pubmed
    ..87% of the benign ovarian tumors. CCND1 gains and amplifications were not associated with the tumor grade and stage. Our results suggest that CCND1 gains are early events in ovarian tumorogenesis. ..
  6. Valacchi G, Pecorelli A, Mencarelli M, Carbotti P, Fortino V, Muscettola M, et al. Rottlerin: a multifaced regulator of keratinocyte cell cycle. Exp Dermatol. 2009;18:516-21 pubmed publisher
    ..These results open the way to further investigation on the Rottlerin therapeutic potential against keratinocyte hyper-proliferative disorders. ..
  7. Romero Benítez M, Aguirre M, Juaristi J, Alvarez M, Trifaro J, Brandan N. In vivo erythroid recovery following paclitaxel injury: correlation between GATA-1, c-MYB, NF-E2, Epo receptor expressions, and apoptosis. Toxicol Appl Pharmacol. 2004;194:230-8 pubmed
  8. Lo H, Hsu S, Ali Seyed M, Gunduz M, Xia W, Wei Y, et al. Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway. Cancer Cell. 2005;7:575-89 pubmed
    ..Our work suggests that the deregulated iNOS/NO pathway may partly contribute to the malignant biology of tumor cells with high levels of nuclear EGFR and STAT3. ..
  9. Yamaura M, Takata M, Miyazaki A, Saida T. Specific dermoscopy patterns and amplifications of the cyclin D1 gene to define histopathologically unrecognizable early lesions of acral melanoma in situ. Arch Dermatol. 2005;141:1413-8 pubmed
    ..The present study also indicates the specificity of the parallel ridge pattern on dermoscopy to detect melanomas on acral volar skin at such a very early developmental phase. ..
  10. Casimiro M, Rodriguez O, Pootrakul L, Aventian M, Lushina N, Cromelin C, et al. ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo. Cancer Res. 2007;67:4364-72 pubmed
    ..Furthermore, our novel mouse model provides a useful platform for ongoing in vivo investigations of ErbB-2 signaling in the prostate epithelium. ..
  11. Lavie G, Kaplinsky C, Toren A, Aizman I, Meruelo D, Mazur Y, et al. A photodynamic pathway to apoptosis and necrosis induced by dimethyl tetrahydroxyhelianthrone and hypericin in leukaemic cells: possible relevance to photodynamic therapy. Br J Cancer. 1999;79:423-32 pubmed
    ..Beyond the tolerated levels of photodynamic damage, these cells died exclusively via necrosis. Hut-78 cells overexpress Bcl-X(L) as well as a truncated Bcl-X(L)tr isoform that could contribute to the observed resistance to apoptosis. ..
  12. Krebs L, Arnold A. Molecular basis of hyperparathyroidism and potential targets for drug development. Curr Drug Targets Immune Endocr Metabol Disord. 2002;2:167-79 pubmed
    ..Attempts to identify new therapies based specifically on the defective pathways in HPT could complement or eventually supplant traditional approaches. ..
  13. Oliver T, Grasfeder L, Carroll A, Kaiser C, Gillingham C, Lin S, et al. Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors. Proc Natl Acad Sci U S A. 2003;100:7331-6 pubmed
    ..Finally, cyclin D1 and N-myc are overexpressed in murine medulloblastoma. These findings suggest that cyclin D1 and N-myc are important mediators of Shh-induced proliferation and tumorigenesis. ..
  14. Simile M, De Miglio M, Muroni M, Frau M, Asara G, Serra S, et al. Down-regulation of c-myc and Cyclin D1 genes by antisense oligodeoxy nucleotides inhibits the expression of E2F1 and in vitro growth of HepG2 and Morris 5123 liver cancer cells. Carcinogenesis. 2004;25:333-41 pubmed
    ..Thus, interactions of c-MYC and CYCLIN D1 with E2F1 gene are essential for cell cycle activity in hepatoma cells, and their inhibition may have a therapeutic effect. ..
  15. Yasumatsu R, Kuratomi Y, Nakashima T, Masuda M, Yamamoto T. Cyclin D1 expression does not effect cell proliferation in adenoid cystic carcinoma of the salivary gland. Eur Arch Otorhinolaryngol. 2004;261:526-30 pubmed
  16. Utikal J, Udart M, Leiter U, Peter R, Krähn G. Additional Cyclin D(1) gene copies associated with chromosome 11 aberrations in cutaneous malignant melanoma. Int J Oncol. 2005;26:597-605 pubmed
    ..Based on these results Cyclin D1 could well be involved in the pathogenesis of a subset of malignant melanoma. Additional studies will have to elucidate the role of further genes located at chromosome 11q13. ..
  17. Irie K, Mishima K, Ishibashi D, Egashira N, Iwasaki K, Fujiwara M. Involvement of bcl-family expression in the spatial memory impairment induced by repeated ischemia. Life Sci. 2002;72:621-9 pubmed
    ..These results suggest that spatial memory impairment at 7 days after repeated ischemia may be related to apoptosis in hippocampal CA1 cells. ..
  18. Chen Q, Lin J, Jinno S, Okayama H. Overexpression of Cdk6-cyclin D3 highly sensitizes cells to physical and chemical transformation. Oncogene. 2003;22:992-1001 pubmed
  19. Donzeau M, Bauersachs S, Blum H, Reichelt P, Röhnisch T, Nagel W. Purification of His-tagged hybrid phage antibody. Anal Biochem. 2006;352:154-6 pubmed
  20. Tsiambas E, Karameris A, Gourgiotis S, Salemis N, Athanassiou A, Karakitsos P, et al. Simultaneous deregulation of p16 and cyclin D1 genes in pancreatic ductal adenocarcinoma: a combined immunohistochemistry and image analysis study based on tissue microarrays. J BUON. 2007;12:261-7 pubmed
    ..This mechanism of genetic deregulation in cell cycle potentially explains in part the aggressive phenotype of this neoplasm. ..
  21. Deckert Schlüter M, Rang A, Wiestler O. Apoptosis and apoptosis-related gene products in primary non-Hodgkin's lymphoma of the central nervous system. Acta Neuropathol. 1998;96:157-62 pubmed
    ..Since there was no statistical correlation between the degree of apoptosis and the expression of proteins of the bcl gene family, other apoptosis-inhibiting factors may be involved in the pathogenesis of primary CNS lymphomas. ..
  22. Nakamura Y, Yasuda T, Weisel R, Li R. Enhanced cell transplantation: preventing apoptosis increases cell survival and ventricular function. Am J Physiol Heart Circ Physiol. 2006;291:H939-47 pubmed
    ..72; P = 0.002) to the number of surviving engrafted cells. ..
  23. Dunphy C, Perkins S. Large cell variants of CD5+, CD23- B-cell lymphoma/leukemia. Arch Pathol Lab Med. 2001;125:513-8 pubmed
    ..Careful analysis of clinical data, morphology, immunophenotype, Cyclin D1 expression, and molecular analysis are required to differentiate the unusual large cell variants of MCL from other processes. ..
  24. Kleist B, Poetsch M, Schmoll J. Intranodal palisaded myofibroblastoma with overexpression of cyclin D1. Arch Pathol Lab Med. 2003;127:1040-3 pubmed
    ..Nevertheless, our results point to the cell cycle regulatory genes as a factor in the pathogenesis of IPM. ..
  25. Glickstein S, Moore H, Slowinska B, Racchumi J, Suh M, Chuhma N, et al. Selective cortical interneuron and GABA deficits in cyclin D2-null mice. Development. 2007;134:4083-93 pubmed
    ..We propose that cD2 promotes transit-amplifying divisions in the SVZ and that these ensure proper output of at least a subset of PV interneurons. ..
  26. Hoechtlen Vollmar W, Menzel G, Bartl R, Lamerz R, Wick M, Seidel D. Amplification of cyclin D1 gene in multiple myeloma: clinical and prognostic relevance. Br J Haematol. 2000;109:30-8 pubmed
    ..The detection of cyclin D1 amplification seems to be of promising prognostic value in multiple myeloma. ..
  27. Bernard M, Gressin R, Lefrere F, Drenou B, Branger B, Caulet Maugendre S, et al. Blastic variant of mantle cell lymphoma: a rare but highly aggressive subtype. Leukemia. 2001;15:1785-91 pubmed
    ..Standard therapy using anthracycline or even high-dose intensification produce poor results and an alternative treatment should be proposed to such patients. ..
  28. Kowara R, Karaczyn A, Cheng R, Salnikow K, Kasprzak K. Microarray analysis of altered gene expression in murine fibroblasts transformed by nickel(II) to nickel(II)-resistant malignant phenotype. Toxicol Appl Pharmacol. 2005;205:1-10 pubmed
  29. Frech M, Torre K, Robinson G, Furth P. Loss of cyclin D1 in concert with deregulated estrogen receptor alpha expression induces DNA damage response activation and interrupts mammary gland morphogenesis. Oncogene. 2008;27:3186-93 pubmed
    ..This differential requirement for cyclin D1 in normal vs abnormal mammary epithelial cells supports the application of cyclin D1 inhibitors as therapeutic interventions in ERalpha-overexpressing breast cancers. ..
  30. Guerra E, Trerotola M, Dell Arciprete R, Bonasera V, Palombo B, El Sewedy T, et al. A bicistronic CYCLIN D1-TROP2 mRNA chimera demonstrates a novel oncogenic mechanism in human cancer. Cancer Res. 2008;68:8113-21 pubmed publisher
    ..The stabilized CYCLIN D1 mRNA cooperates with TROP2 in stimulating the growth of the expressing cells. These findings show a novel epigenetic, oncogenic mechanism, which seems to be widespread in human cancers. ..
  31. Hsiang C, Straus D. Cyclopentenone causes cell cycle arrest and represses cyclin D1 promoter activity in MCF-7 breast cancer cells. Oncogene. 2002;21:2212-26 pubmed
    ..The overall results suggest that cyclopentenone interferes with the transcription initiation complex that assembles over the cyclin D1 initiator element, leading to selective inhibition of cyclin D1 gene transcription. ..
  32. Boonyaratanakornkit V, McGowan E, Sherman L, Mancini M, Cheskis B, Edwards D. The role of extranuclear signaling actions of progesterone receptor in mediating progesterone regulation of gene expression and the cell cycle. Mol Endocrinol. 2007;21:359-75 pubmed
    ..These results highlight the importance of PR activation of the Src/MAPK signaling pathway for progesterone-induced transcription of select target genes and cell cycle progression. ..
  33. Zhao X, Song T, He Z, Tang L, Zhu Y. A novel role of cyclinD1 and p16 in clinical pathology and prognosis of childhood medulloblastoma. Med Oncol. 2010;27:985-91 pubmed publisher
    ..CyclinD1 and p16 may be independent biomarkers for clinical prognosis in MB. A combined detection of cyclinD1+/p16- expression may benefit us in prediction of a poor survival of MB. ..
  34. Borjas Fajardo L, Pineda Del Villar L, Arteaga Vizcaíno M, Morales Machin A, Delgado W, Martínez Basalo C. [Analysis of Bcl I polymorphism of factor VIII gene in the molecular diagnosis of female hemophilia A carriers in families from northwestern Venezuela]. Sangre (Barc). 1999;44:19-23 pubmed
    ..It's possible to identify carriers for haemophilia A in most of the families from Zulia state-Venezuela employing several polymorphisms at the Factor VIII gene. ..
  35. Akervall J, Kurnit D, Adams M, Zhu S, Fisher S, Bradford C, et al. Overexpression of cyclin D1 correlates with sensitivity to cisplatin in squamous cell carcinoma cell lines of the head and neck. Acta Otolaryngol. 2004;124:851-7 pubmed
    ..Our results support the hypothesis that overexpression of cyclin D1 is one of the molecular factors that can be used to predict sensitivity to chemotherapy, thus enabling individualization of treatment of head and neck cancer. ..
  36. Bose B, Gour R, Motiwale L, Gupta S, Rao K. Hyperphosphorylation of extracellular regulated kinase 2 (ERK2) and inhibition of JNK2 phosphorylation are associated with increased S-phase during transformation of Syrian hamster embryo cells by Malachite Green. Cell Biol Int. 2004;28:875-83 pubmed
  37. Zhang L, Insel P. Bcl-2 protects lymphoma cells from apoptosis but not growth arrest promoted by cAMP and dexamethasone. Am J Physiol Cell Physiol. 2001;281:C1642-7 pubmed
    ..The findings also indicate that glucocorticoid- and cAMP-mediated G(1) growth arrest is unaffected by Bcl-2 overexpression, even though increased Bcl-2 allows these lymphoma cells to resist necrosis and apoptosis. ..
  38. Angelopoulou M, Siakantariz M, Vassilakopoulos T, Kontopidou F, Rassidakis G, Dimopoulou M, et al. The splenic form of mantle cell lymphoma. Eur J Haematol. 2002;68:12-21 pubmed
    ..We conclude that this presentation represents a separate form of MCL which requires splenectomy. It remains to be seen whether it carries a better prognosis than classical MCL. ..
  39. Wong Y, Lin S, Chang C, Tseng Y, Liu C, Lin H, et al. Cyclin D1 genotype in areca-associated oral squamous cell carcinoma. J Oral Pathol Med. 2003;32:265-70 pubmed
    ..02). In addition, amplification of CCND1 was significantly more prevalent in OSCC cases (22%) than in control subjects (2%, P < 0.01). This study demonstrates that the CCND1 genotype may confer different risks for BSCC and non-BSCC. ..
  40. Sathyan K, Nalinakumari K, Abraham T, Kannan S. Influence of single nucleotide polymorphisms in H-Ras and cyclin D1 genes on oral cancer susceptibility. Oral Oncol. 2006;42:607-13 pubmed
  41. Naegele J. Neuroprotective strategies to avert seizure-induced neurodegeneration in epilepsy. Epilepsia. 2007;48 Suppl 2:107-17 pubmed
    ..Such comparative studies will also aid in evaluating the potential therapeutic value of inhibiting cell death in seizure disorders. ..
  42. Lassaletta L, Patron M, Del Rio L, Alfonso C, Roda J, Rey J, et al. Cyclin D1 expression and histopathologic features in vestibular schwannomas. Otol Neurotol. 2007;28:939-41 pubmed
    ..To evaluate cyclin D1 expression in vestibular schwannoma and its relationship with histologic, clinical, and radiologic features...
  43. Mohamed A, Elwakil T, Taher I, Elbarbary M, Kayed H, Hussein H, et al. Cyclin D1 gene amplification in proliferating haemangioma. Cell Tissue Res. 2009;338:107-15 pubmed publisher
    ..The present findings reflect the possible usefulness of antisense cyclin D1 to improve the therapeutic outcome of proliferating haemangiomas. ..
  44. Norum J, Tranebjaerg L. Health, life and disability insurance and hereditary risk for breast or colorectal cancer. Acta Oncol. 2000;39:189-93 pubmed
    ..Only the major Norwegian insurer is in fact diverging in its policies. ..
  45. Gugger M, Burckhardt E, Kappeler A, Hirsiger H, Laissue J, Mazzucchelli L. Quantitative expansion of structural genomic alterations in the spectrum of neuroendocrine lung carcinomas. J Pathol. 2002;196:408-15 pubmed
    ..The quantitative expansion of the Rb, p53, c-myc, and Her-2/neu alterations towards high-grade carcinomas suggests common pathogenetic mechanisms in the spectrum of these neoplasms. ..
  46. Blankenberg F. To scan or not to scan, it is a question of timing: technetium-99m-annexin V radionuclide imaging assessment of treatment efficacy after one course of chemotherapy. Clin Cancer Res. 2002;8:2757-8 pubmed
  47. Raybaud H, Odin G, Fafet A, Santini J, Monteil R. [Genic alterations in oral and head and neck squamous cell carcinomas: analysis of international literature]. Pathol Biol (Paris). 2003;51:176-84 pubmed
    ..By blocking apoptosis, the Bcl2 protein seems to increase the resistance of tumours to radiotherapy and chemotherapy. ..
  48. Mallya S, Gallagher J, Wild Y, Kifor O, Costa Guda J, Saucier K, et al. Abnormal parathyroid cell proliferation precedes biochemical abnormalities in a mouse model of primary hyperparathyroidism. Mol Endocrinol. 2005;19:2603-9 pubmed
  49. Currier N, Solomon S, Demicco E, Chang D, Farago M, Ying H, et al. Oncogenic signaling pathways activated in DMBA-induced mouse mammary tumors. Toxicol Pathol. 2005;33:726-37 pubmed
    ..These data suggest that environmental carcinogens can produce long-lasting alterations in growth and anti-apoptotic pathways, leading to mammary tumorigenesis. ..
  50. Keophiphath M, Achard V, Henegar C, Rouault C, Clement K, Lacasa D. Macrophage-secreted factors promote a profibrotic phenotype in human preadipocytes. Mol Endocrinol. 2009;23:11-24 pubmed publisher
    ..This phenomenon might play a role in facilitating the constitution of quiescent preadipocyte pools and eventually in the maintenance and aggravation of increased fat mass in obesity. ..
  51. Chodosh L. The reciprocal dance between cancer and development. N Engl J Med. 2002;347:134-6 pubmed
  52. Almadori G, Galli J, Cadoni G, Bussu F, Maurizi M. Human papillomavirus infection and cyclin D1 gene amplification in laryngeal squamous cell carcinoma: biologic function and clinical significance. Head Neck. 2002;24:597-604 pubmed
  53. Zecevic M, Amos C, Gu X, Campos I, Jones J, Lynch P, et al. IGF1 gene polymorphism and risk for hereditary nonpolyposis colorectal cancer. J Natl Cancer Inst. 2006;98:139-43 pubmed
    ..This is the first report, to our knowledge, to show that IGF1 variant genotypes modify risk of a hereditary form of cancer. ..
  54. Wang S, Cozen W, Severson R, Hartge P, Cerhan J, Davis S, et al. Cyclin D1 splice variant and risk for non-Hodgkin lymphoma. Hum Genet. 2006;120:297-300 pubmed
    ..4, 95% CI = 1.1-1.8, P-trend = 0.021), which was consistent for four B-cell subtypes. As CCND1 expression indicates poor NHL prognosis, our results, if true, would support its potentially dual importance in NHL etiology and survival. ..
  55. Wickham C, Harries L, Sarsfield P, Joyner M, Ellard S. Large variation in t(11;14)(q13;q32) and t(14;18)(q32;q21) translocation product size is confirmed by sequence analysis of PCR products. Clin Lab Haematol. 2006;28:248-53 pubmed
    ..We demonstrate the utility of sequence analysis to confirm unusual-sized translocation products and reduce false-positive results because of nonspecific amplification. ..
  56. Lee J, Au A, Foukakis T, Barbaro M, Kiss N, Clifton Bligh R, et al. Array-CGH identifies cyclin D1 and UBCH10 amplicons in anaplastic thyroid carcinoma. Endocr Relat Cancer. 2008;15:801-15 pubmed publisher
    ..In summary, the recurrent chromosomal copy number changes and molecular alterations identified in this study may provide an insight into the pathogenesis and development of ATC. ..
  57. Yu Q, Geng Y, Sicinski P. Specific protection against breast cancers by cyclin D1 ablation. Nature. 2001;411:1017-21 pubmed
    ..Our results suggest that an anti-cyclin D1 therapy might be highly specific in treating human breast cancers with activated Neu-Ras pathways. ..
  58. Ho Pun Cheung A, Assenat E, Thezenas S, Bibeau F, Rouanet P, Azria D, et al. Cyclin D1 gene G870A polymorphism predicts response to neoadjuvant radiotherapy and prognosis in rectal cancer. Int J Radiat Oncol Biol Phys. 2007;68:1094-101 pubmed
    ..003) and overall (p = 0.044) survival. Although CCND1 exon 5 mutations are rare in rectal cancer, G870A polymorphism is a frequent variation that may predict radiosensitivity and prognosis. ..
  59. Mangel J, Buckstein R, Imrie K, Spaner D, Crump M, Tompkins K, et al. Immunotherapy with rituximab following high-dose therapy and autologous stem-cell transplantation for mantle cell lymphoma. Semin Oncol. 2002;29:56-69 pubmed
    ..Although patient numbers are low and follow-up time is short, preliminary results are encouraging. Rituximab may convert partial responders to complete responders. The durability of responses will be determined with longer follow-up. ..
  60. Caproni M, Torchia D, Antiga E, Degl Innocenti D, Barletta E, Baroni G, et al. The role of apoptosis in the pathogenesis of dermatitis herpetiformis. Int J Immunopathol Pharmacol. 2005;18:691-9 pubmed
    ..We conclude that in DH, as well as in BP, apoptosis plays a role in the pathogenesis of cutaneous lesions in concert with other pathogenetic mechanisms. ..
  61. SZOKA F. Molecular biology. The art of assembly. Science. 2008;319:578-9 pubmed publisher
  62. Westin G, Björklund P, Akerstrom G. Molecular genetics of parathyroid disease. World J Surg. 2009;33:2224-33 pubmed publisher
    ..Molecular genetic studies of parathyroid tumors are well designed basic experimental studies providing strong level III evidence, with data frequently confirmed by subsequent studies. ..
  63. Liu X, Tang Z. BCL-1 rearrangement in acute lymphocytic leukemia and its clinical significance. J Tongji Med Univ. 2001;21:283-5 pubmed
    ..It was concluded that: 1) BCL-1/IgH gene rearrangement were detected in acute B lymphocytic leukemia; 2) B-ALL patients with BCL-1 rearrangement and (or) cyclin D1 protein expression had poor prognosis. ..
  64. Krippl P, Langsenlehner U, Renner W, Yazdani Biuki B, Wolf G, Wascher T, et al. The 870G>A polymorphism of the cyclin D1 gene is not associated with breast cancer. Breast Cancer Res Treat. 2003;82:165-8 pubmed
    ..CCND1 genotype frequencies were similar among patients and controls. The CCND1 genotype was furthermore not associated with tumor characteristics. We conclude that the CCND1 870G > A polymorphism is not associated with breast cancer. ..
  65. Kawakami K, Miyanishi S, Sonoki T, Nakamura S, Nomura K, Taniwaki M, et al. Case of B-cell lymphoma with rearrangement of the BCL1, BCL2, BCL6, and c-MYC genes. Int J Hematol. 2004;79:474-9 pubmed
    ..Lymphadenopathy showed a quick and complete response to doxorubicin-containing systemic chemotherapy with rituximab, but the central nervous system disease progressed and killed the patient. ..
  66. Cubas R, Li M, Chen C, Yao Q. Trop2: a possible therapeutic target for late stage epithelial carcinomas. Biochim Biophys Acta. 2009;1796:309-14 pubmed publisher
  67. Hwang L, Murray A. A novel yeast screen for mitotic arrest mutants identifies DOC1, a new gene involved in cyclin proteolysis. Mol Biol Cell. 1997;8:1877-87 pubmed
    ..Cdc26 associates in vivo with Doc1, Cdc16, Cdc23, and Cdc27. In addition, the majority of Doc1 cosediments at 20S with Cdc27 in a sucrose gradient, indicating that Cdc26 and Doc1 are components of the anaphase promoting complex. ..
  68. Planas Silva M, Shang Y, Donaher J, Brown M, Weinberg R. AIB1 enhances estrogen-dependent induction of cyclin D1 expression. Cancer Res. 2001;61:3858-62 pubmed
    ..Increases of AIB1 levels in breast cancer cells by amplification and/or overexpression may represent one way to confer estrogen-dependent mitogenic stimulation to breast cancer cells. ..
  69. Lee K, Sohn I, Kim Y, Choi J, Choi J, Park H, et al. Tectorigenin, an isoflavone of Pueraria thunbergiana Benth., induces differentiation and apoptosis in human promyelocytic leukemia HL-60 cells. Biol Pharm Bull. 2001;24:1117-21 pubmed
    ..From these results, tectorigenin may be a possible therapeutic agent for leukemia...
  70. Di Blasio A, van Rossum E, Maestrini S, Berselli M, Tagliaferri M, Podesta F, et al. The relation between two polymorphisms in the glucocorticoid receptor gene and body mass index, blood pressure and cholesterol in obese patients. Clin Endocrinol (Oxf). 2003;59:68-74 pubmed
    ..Furthermore, these data suggest that N363S carriers who carry the BclI polymorphism as well, tend to have a slightly unfavourable cardiovascular profile. ..
  71. Garnis C, Campbell J, Zhang L, Rosin M, Lam W. OCGR array: an oral cancer genomic regional array for comparative genomic hybridization analysis. Oral Oncol. 2004;40:511-9 pubmed
    ..This work represents the first attempt at the construction of an oral cancer-specific CGH array. ..
  72. Yu J, Habuchi T, Tsuchiya N, Nakamura E, Kakinuma H, Horikawa Y, et al. Association of the cyclin D1 gene G870A polymorphism with susceptibility to sporadic renal cell carcinoma. J Urol. 2004;172:2410-3 pubmed
    ..More extensive and larger studies are required to clarify whether the CCND1 genotype is more specifically involved in the onset of a histological subset of RCC or RCC at a younger age. ..
  73. Bala S, Peltomaki P. CYCLIN D1 as a genetic modifier in hereditary nonpolyposis colorectal cancer. Cancer Res. 2001;61:6042-5 pubmed
  74. Natsume H, Sasaki S, Kitagawa M, Kashiwabara Y, Matsushita A, Nakano K, et al. Beta-catenin/Tcf-1-mediated transactivation of cyclin D1 promoter is negatively regulated by thyroid hormone. Biochem Biophys Res Commun. 2003;309:408-13 pubmed
    ..These results indicate that the T3-bound TR inhibits the transcription of cyclin D1 through the Tcf/Lef-1 site, which is positively regulated by the Wnt-signaling pathway. ..
  75. Magné S, Caron S, Charon M, Rouyez M, Dusanter Fourt I. STAT5 and Oct-1 form a stable complex that modulates cyclin D1 expression. Mol Cell Biol. 2003;23:8934-45 pubmed
    ..Our data offer new insights into the transcriptional regulation of the key cell cycle regulator cyclin D1 and emphasize the active roles of both STAT5 and Oct-1 in this process. ..
  76. Singh R, Dasgupta S, Bhattacharya N, Chunder N, Mondal R, Roy A, et al. Deletion in chromosome 11 and Bcl-1/Cyclin D1 alterations are independently associated with the development of uterine cervical carcinoma. J Cancer Res Clin Oncol. 2005;131:395-406 pubmed
    ..11 and Bcl-1/Cyclin D1 alterations, but these alterations may provide cumulative effect in progression of the tumor. The D1-D3 regions may harbor candidate tumor suppressor gene(s) (TSGs) associated with the development of CA-CX. ..
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