Top Publications

  1. Bonet C, Luciani F, Ottavi J, Leclerc J, Jouenne F, Boncompagni M, et al. Deciphering the Role of Oncogenic MITFE318K in Senescence Delay and Melanoma Progression. J Natl Cancer Inst. 2017;109: pubmed publisher
    ..Here, we compared the SUMOylation status of endogenous MITF by proximity ligation assay in melanocytes isolated from wild-type (n = ..
  2. Tozluoğlu M, Karaca E, Nussinov R, Haliloglu T. A mechanistic view of the role of E3 in sumoylation. PLoS Comput Biol. 2010;6: pubmed publisher
    b>Sumoylation, the covalent attachment of SUMO (Small Ubiquitin-Like Modifier) to proteins, differs from other Ubl (Ubiquitin-like) pathways...
  3. Luo J, Gurung S, Lee L, Henley J, Wilkinson K, Guo C. Increased SUMO-2/3-ylation mediated by SENP3 degradation is protective against cadmium-induced caspase 3-dependent cytotoxicity. J Toxicol Sci. 2017;42:529-538 pubmed publisher
    ..However, it is still unclear what other cell stressors trigger protein SUMOylation, what mechanisms enhance and maintain the enhanced SUMOylation, and if it is a general protective mediator ..
  4. Lee J, Won H, Park J, Kim H, Choi H, Shin D, et al. MEL-18 loss mediates estrogen receptor-α downregulation and hormone independence. J Clin Invest. 2015;125:1801-14 pubmed publisher
    ..MEL-18 suppressed SUMOylation of the ESR1 transactivators p53 and SP1, thereby driving ESR1 transcription...
  5. Yue X, Zhang C, Zhao Y, Liu J, Lin A, Tan V, et al. Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression. Genes Dev. 2017;31:1641-1654 pubmed publisher
    ..and inhibits its interaction with SUMO-specific protease 1 (SENP1), which in turn inhibits SENP1-mediated de-SUMOylation of Rac1 to activate Rac1...
  6. Li K, Wang F, Cao W, Lv X, Hua F, Cui B, et al. TRIB3 Promotes APL Progression through Stabilization of the Oncoprotein PML-RARα and Inhibition of p53-Mediated Senescence. Cancer Cell. 2017;31:697-710.e7 pubmed publisher
    ..The elevated TRIB3 expression promotes APL by interacting with PML-RARα and suppressing its sumoylation, ubiquitylation, and degradation...
  7. Nie M, Moser B, Nakamura T, Boddy M. SUMO-targeted ubiquitin ligase activity can either suppress or promote genome instability, depending on the nature of the DNA lesion. PLoS Genet. 2017;13:e1006776 pubmed publisher
    ..Finally, we find that Taz1TRF1/TRF2-deficiency triggers extensive telomeric poly-SUMOylation. In this setting STUbL, together with its cofactor Cdc48p97, actually promotes genomic instability caused by ..
  8. Tan M, Zhang D, Zhang E, Xu D, Liu Z, Qiu J, et al. SENP2 suppresses epithelial-mesenchymal transition of bladder cancer cells through deSUMOylation of TGF-βRI. Mol Carcinog. 2017;56:2332-2341 pubmed publisher
    ..Our results establish a function of SENP2 in metastatic progression and suggest its candidacy as a new prognostic biomarker and target for clinical management of bladder cancer. ..
  9. Baczyk D, Audette M, Drewlo S, Levytska K, Kingdom J. SUMO-4: A novel functional candidate in the human placental protein SUMOylation machinery. PLoS ONE. 2017;12:e0178056 pubmed publisher
    ..We tested the hypothesis that SUMO-4 is expressed in the human placenta and demonstrates altered SUMOylation in pre-eclamptic pregnancies...

More Information


  1. Dhall A, Weller C, Chu A, Shelton P, Chatterjee C. Chemically Sumoylated Histone H4 Stimulates Intranucleosomal Demethylation by the LSD1-CoREST Complex. ACS Chem Biol. 2017;12:2275-2280 pubmed publisher
    ..Thus, we have identified histone modification by SUMO as the first PTM that stimulates intranucleosomal demethylation by the developmentally critical LSD1-CoREST complex. ..
  2. Shen Q, Beyrouthy N, Matabishi Bibi L, Dargemont C. The chromatin remodeling Isw1a complex is regulated by SUMOylation. Biochem J. 2017;474:3455-3469 pubmed publisher
    ..Extensive site-directed mutagenesis allowed us to identify the major SUMOylation sites and develop a SUMO-defective mutant of Isw1...
  3. Liang J, Singh N, Carlson C, Albuquerque C, Corbett K, Zhou H. Recruitment of a SUMO isopeptidase to rDNA stabilizes silencing complexes by opposing SUMO targeted ubiquitin ligase activity. Genes Dev. 2017;31:802-815 pubmed publisher
    ..Overall, our results demonstrate how the opposing actions of a localized SUMO isopeptidase and a STUbL regulate rDNA silencing by controlling the abundance of a key rDNA silencing protein, Tof2. ..
  4. Wang C, Liu H, Luo J, Chen L, Li M, Su W, et al. HA Triggers the Switch from MEK1 SUMOylation to Phosphorylation of the ERK Pathway in Influenza A Virus-Infected Cells and Facilitates Its Infection. Front Cell Infect Microbiol. 2017;7:27 pubmed publisher
    ..We hypothesized that the MAPK/ERK pathway could be modified by SUMO1 because the SUMOylation of MEK1 was quickly eliminated after influenza A virus infection...
  5. Li J, Callegari S, Masucci M. The Epstein-Barr virus miR-BHRF1-1 targets RNF4 during productive infection to promote the accumulation of SUMO conjugates and the release of infectious virus. PLoS Pathog. 2017;13:e1006338 pubmed publisher
    ..during the late phase of the productive virus cycle, and identified several viral proteins as bone fide SUMOylation substrates...
  6. Surana P, Gowda C, Tripathi V, Broday L, Das R. Structural and functional analysis of SMO-1, the SUMO homolog in Caenorhabditis elegans. PLoS ONE. 2017;12:e0186622 pubmed publisher
    ..SMO-1 can bind to typical SUMO Interacting Motifs (SIMs). SMO-1 can also conjugate to a typical SUMOylation consensus site as well as to its natural substrate HMR-1...
  7. Jox T, Buxa M, Bohla D, Ullah I, Macinkovic I, Brehm A, et al. Drosophila CP190- and dCTCF-mediated enhancer blocking is augmented by SUMOylation. Epigenetics Chromatin. 2017;10:32 pubmed publisher
    ..b>SUMOylation augments the enhancer blocking function of four different insulator sequences and increases the genome-wide ..
  8. Dhingra N, Zhao X. SUMO Teams Up with a Translocase to Save TOPO. Mol Cell. 2017;66:577-578 pubmed publisher
    ..2017) report how a DNA translocase uses SUMO as a cue to save Top2 from ubiquitin-mediated degradation and to minimize DNA breaks, thus providing insights into the SUMO and ubiquitin interplay in genome maintenance. ..
  9. Dasso M. Biochemistry: Rear view of an enzyme. Nature. 2013;497:576-7 pubmed publisher
  10. Kaur K, Park H, Pandey N, Azuma Y, De Guzman R. Identification of a new small ubiquitin-like modifier (SUMO)-interacting motif in the E3 ligase PIASy. J Biol Chem. 2017;292:10230-10238 pubmed publisher
    ..b>SUMOylation depends on the sequential activities of E1 activating, E2 conjugating, and E3 ligating enzymes...
  11. Cheng C, Chu C, Hsu H, Hsu F, Tang C, Wang W, et al. An improved ChIP-seq peak detection system for simultaneously identifying post-translational modified transcription factors by combinatorial fusion, using SUMOylation as an example. BMC Genomics. 2014;15 Suppl 1:S1 pubmed publisher
  12. Liang Z, Yang Y, He Y, Yang P, Wang X, He G, et al. SUMOylation of IQGAP1 promotes the development of colorectal cancer. Cancer Lett. 2017;411:90-99 pubmed publisher
    ..An aberrant expression of IQGAP1 widely exists in many cancers, but the SUMOylation modification of IQGAP1 in carcinogenesis is unknown by now...
  13. McManus F, Lamoliatte F, Thibault P. Identification of cross talk between SUMOylation and ubiquitylation using a sequential peptide immunopurification approach. Nat Protoc. 2017;12:2342-2358 pubmed publisher
    ..We recently developed an approach that permits the identification of proteins that are modified by both SUMOylation and ubiquitylation...
  14. Zhu X, Ding S, Qiu C, Shi Y, Song L, Wang Y, et al. SUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling. Circ Res. 2017;121:636-649 pubmed publisher indicated the potential role of post-translational SUMO (small ubiquitin-like modifier) modification (SUMOylation) in vascular disorders...
  15. Morris J, Garvin A. SUMO in the DNA Double-Stranded Break Response: Similarities, Differences, and Cooperation with Ubiquitin. J Mol Biol. 2017;429:3376-3387 pubmed publisher
    ..Here, we summarise our emerging understanding of SUMOylation both as a distinct modification and as a cooperative modification with Ub, using the cellular response to DNA ..
  16. He X, Riceberg J, Soucy T, Koenig E, Minissale J, Gallery M, et al. Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor. Nat Chem Biol. 2017;13:1164-1171 pubmed publisher
    ..ML-792 selectively blocks SAE enzyme activity and total SUMOylation, thus decreasing cancer cell proliferation...
  17. Tessé S, Bourbon H, Debuchy R, Budin K, Dubois E, Liangran Z, et al. Asy2/Mer2: an evolutionarily conserved mediator of meiotic recombination, pairing, and global chromosome compaction. Genes Dev. 2017;31:1880-1893 pubmed publisher
    ..Third, after completion of recombination, potentially dependent on SUMOylation, Mer2 mediates global chromosome compaction and post-recombination chiasma development...
  18. Chanda A, Chan A, Deng L, Kornaga E, Enwere E, Morris D, et al. Identification of the SUMO E3 ligase PIAS1 as a potential survival biomarker in breast cancer. PLoS ONE. 2017;12:e0177639 pubmed publisher
    ..In mechanistic studies, we find that PIAS1 acts via sumoylation of the transcriptional regulator SnoN to suppress invasive growth of MDA-MB-231 human breast cancer cell-..
  19. Vierstra R. The expanding universe of ubiquitin and ubiquitin-like modifiers. Plant Physiol. 2012;160:2-14 pubmed publisher
  20. Zhang X, Wang H, Wang H, Xiao F, Seth P, Xu W, et al. SUMO-Specific Cysteine Protease 1 Promotes Epithelial Mesenchymal Transition of Prostate Cancer Cells via Regulating SMAD4 deSUMOylation. Int J Mol Sci. 2017;18: pubmed publisher
    ..Moreover, down-regulation of SMAD4 and E-cadherin were blocked, after transfection with two SUMOylation sites mutated SMAD4, suggesting that SENP1 might reduce SMAD4 levels to regulate E-cadherin expression via ..
  21. Kanao R, Masutani C. Regulation of DNA damage tolerance in mammalian cells by post-translational modifications of PCNA. Mutat Res. 2017;803-805:82-88 pubmed publisher
    ..Furthermore, SUMOylation of PCNA in mammalian cells can negatively regulate recombination...
  22. Xing Y, Morohashi K, Ingraham H, Hammer G. Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1. Development. 2017;144:3798-3807 pubmed publisher
    ..Here, we have examined the function of Sf1 SUMOylation and its interaction with Dax1 on FAdE function...
  23. Weir G. Islet-cell biology in 2015: Understanding secretion, ageing and death in ? cells. Nat Rev Endocrinol. 2016;12:72-4 pubmed publisher
  24. Chua J, Reddy S, Yu Z, Giorgetti E, Montie H, Mukherjee S, et al. Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor-mediated disease. J Clin Invest. 2015;125:831-45 pubmed publisher
    ..To accomplish this, we bypassed the inhibitory effect of AR SUMOylation (where SUMO indicates small ubiquitin-like modifier) by mutating conserved lysines in the polyQ AR that are ..
  25. Garbuz D. [Regulation of heat shock gene expression in response to stress]. Mol Biol (Mosk). 2017;51:400-417 pubmed publisher
    ..In addition, specific signal sequences in the 5'-UTRs of some HS protein mRNAs ensure their preferential translation in stress. ..
  26. Yavuz A, Sezerman O. Predicting sumoylation sites using support vector machines based on various sequence features, conformational flexibility and disorder. BMC Genomics. 2014;15 Suppl 9:S18 pubmed publisher
    b>Sumoylation, which is a reversible and dynamic post-translational modification, is one of the vital processes in a cell...
  27. Ouenzar F, Lalonde M, Laprade H, Morin G, Gallardo F, Tremblay Belzile S, et al. Cell cycle-dependent spatial segregation of telomerase from sites of DNA damage. J Cell Biol. 2017;216:2355-2371 pubmed publisher
    ..This study reveals novel roles for Pif1, Rad52, and Siz1-dependent sumoylation in the spatial exclusion of telomerase from sites of DNA repair.
  28. Alcaide Loridan C, Jupin I. Ubiquitin and plant viruses, let's play together!. Plant Physiol. 2012;160:72-82 pubmed publisher
  29. Benoit Y, Mitchell R, Risueno R, Orlando L, Tanasijevic B, Boyd A, et al. Sam68 Allows Selective Targeting of Human Cancer Stem Cells. Cell Chem Biol. 2017;24:833-844.e9 pubmed publisher
    ..Our study identifies Sam68 as a regulator of human CSC vulnerability. ..
  30. Knittle A, Helkkula M, Johnson M, Sundvall M, Elenius K. SUMOylation regulates nuclear accumulation and signaling activity of the soluble intracellular domain of the ErbB4 receptor tyrosine kinase. J Biol Chem. 2017;292:19890-19904 pubmed publisher
    ..Although ErbB4 kinase activity was not necessary for the SUMOylation, the SUMOylated ErbB4 ICD was tyrosine phosphorylated to a higher extent than unmodified ErbB4 ICD...
  31. Cheng J, Ye F, Dan G, Zhao Y, Zhao J, Zou Z. Formation and degradation of nitrogen mustard-induced MGMT-DNA crosslinking in 16HBE cells. Toxicology. 2017;389:67-73 pubmed publisher
    ..Our results demonstrated the control of mDPC level could be realized through transcription inhibitory effect of c-Myc, O6GB application, and the acceleration of mDPC ubiquitination and subsequent degradation. ..
  32. Li J, Lam W, Lai T, Au S. Degradation of nuclear Ubc9 induced by listeriolysin O is dependent on K+ efflux. Biochem Biophys Res Commun. 2017;493:1115-1121 pubmed publisher
    ..Previous studies have demonstrated that LLO triggers Ubc9 degradation and disrupts host SUMOylation to facilitate bacterial infection. However, the underlying mechanism of Ubc9 degradation is unclear...
  33. Wiechmann S, Gärtner A, Kniss A, Stengl A, Behrends C, Rogov V, et al. Site-specific inhibition of the small ubiquitin-like modifier (SUMO)-conjugating enzyme Ubc9 selectively impairs SUMO chain formation. J Biol Chem. 2017;292:15340-15351 pubmed publisher
    ..However, molecular tools to dissect pathways depending on either mono- or poly-SUMOylation are largely missing...
  34. Yang F, Ma Q, Liu Z, Li W, Tan Y, Jin C, et al. Glucocorticoid Receptor:MegaTrans Switching Mediates the Repression of an ERα-Regulated Transcriptional Program. Mol Cell. 2017;66:321-331.e6 pubmed publisher
    ..Consistent with the effects of SUMOylation on other classes of nuclear receptors, dexamethasone (Dex)-induced trans-repression of the estrogen E2
  35. Mevissen T, Komander D. Mechanisms of Deubiquitinase Specificity and Regulation. Annu Rev Biochem. 2017;86:159-192 pubmed publisher
    ..We further discuss the many mechanisms of DUB regulation with a focus on those that modulate catalytic activity. Our review provides a framework to tackle lingering questions in DUB biology. ..
  36. Kim S, Yoon H, Park S, Lee M, Shin J, Ryu K, et al. Srs2 possesses a non-canonical PIP box in front of its SBM for precise recognition of SUMOylated PCNA. J Mol Cell Biol. 2012;4:258-61 pubmed publisher
  37. Takemoto M, Kawamura Y, Hirohama M, Yamaguchi Y, Handa H, Saitoh H, et al. Inhibition of protein SUMOylation by davidiin, an ellagitannin from Davidia involucrata. J Antibiot (Tokyo). 2014;67:335-8 pubmed publisher
  38. Hu M, Liao C, Yang Q, Xie X, Shu H. Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5. J Exp Med. 2017;214:973-989 pubmed publisher
    ..regulates MDA5- and RIG-I-mediated induction of downstream genes and acts as a SUMO E3 ligase for their dynamic sumoylation at K43/K865 and K96/K888, respectively, before and after viral infection...
  39. Chandhoke A, Chanda A, Karve K, Deng L, Bonni S. The PIAS3-Smurf2 sumoylation pathway suppresses breast cancer organoid invasiveness. Oncotarget. 2017;8:21001-21014 pubmed publisher
    ..Here, we report that the E3 ubiquitin ligase Smurf2 acts in a sumoylation-dependent manner to suppress the invasive behavior of MDA-MB-231 human breast cancer cell-derived organoids...
  40. Iyengar P. Regulation of Ubiquitin Enzymes in the TGF-? Pathway. Int J Mol Sci. 2017;18: pubmed publisher
    ..This review summarizes the roles of specific ubiquitin modifying enzymes in the TGF-? pathway and how they are regulated. ..
  41. Liu H, Yan S, Ding J, Yu T, Cheng S. DeSUMOylation of Gli1 by SENP1 Attenuates Sonic Hedgehog Signaling. Mol Cell Biol. 2017;37: pubmed publisher
    ..factors, Gli1 to -3, which undergo extensive posttranslational modifications, including ubiquitination and SUMOylation. Here, we report that the sentrin-specific peptidase SENP1 is the specific deSUMOylation enzyme for Gli1...
  42. Dhingra N, Zhao X. A guide for targeted SUMO removal. Genes Dev. 2017;31:719-720 pubmed publisher
    ..802-815) demonstrate how a desumoylation enzyme is targeted to the nucleolus for removing SUMO from specific substrates and how curtailing sumoylation levels can regulate transcription in this nuclear compartment.
  43. Jiménez Canino R, Lorenzo Díaz F, Odermatt A, Bailey M, Livingstone D, Jaisser F, et al. 11?-HSD2 SUMOylation Modulates Cortisol-Induced Mineralocorticoid Receptor Nuclear Translocation Independently of Effects on Transactivation. Endocrinology. 2017;158:4047-4063 pubmed publisher
    ..Taken together, our data suggests that SUMOylation of 11?-HSD2 at residue K266 modulates cortisol-mediated MR nuclear translocation independently of effects on ..
  44. Han C, Zhao R, Kroger J, He J, Wani G, Wang Q, et al. UV radiation-induced SUMOylation of DDB2 regulates nucleotide excision repair. Carcinogenesis. 2017;38:976-985 pubmed publisher
    ..Mapping of SUMO-modified sites demonstrated that UVR-induced SUMOylation occurs on Lys-309 residue of DDB2 protein...
  45. Li X, Zeng Y, Sun R, Liu M, Chen S, Zhang P. SUMOylation in cardiac disorders - a review. Eur Rev Med Pharmacol Sci. 2017;21:1583-1587 pubmed
    b>SUMOylation regulates diverse cellular processes including transcription, cell cycle, protein stability, and apoptosis. A recent research has now revealed the role of SUMO1 in cardiac disorders...
  46. Xiao Y, Lucas B, Molcho E, Vigodner M. Cross-talk between sumoylation and phosphorylation in mouse spermatocytes. Biochem Biophys Res Commun. 2017;487:640-645 pubmed publisher
    ..b>Sumoylation has emerged as a critical regulatory event in several developmental processes, including reproduction...
  47. Wei Y, Diao L, Lu S, Wang H, Suo F, Dong M, et al. SUMO-Targeted DNA Translocase Rrp2 Protects the Genome from Top2-Induced DNA Damage. Mol Cell. 2017;66:581-596.e6 pubmed publisher
    ..Loss of Rrp2 enhances SUMOylation-dependent ubiquitination and degradation of Top2, which in turn increases DNA damage at sites where Top2-DNA ..