Summary: The act of ligating UBIQUITINS to PROTEINS to form ubiquitin-protein ligase complexes to label proteins for transport to the PROTEASOME ENDOPEPTIDASE COMPLEX where proteolysis occurs.

Top Publications

  1. Sollid L, Villadangos J. Antigen processing. Curr Opin Immunol. 2013;25:71-3 pubmed publisher
  2. Jang J, Park K, Lee J, Ko K, Kang S, Kim I. Selenoprotein S is required for clearance of C99 through endoplasmic reticulum-associated degradation. Biochem Biophys Res Commun. 2017;486:444-450 pubmed publisher
    ..The ubiquitination of C99 was decreased in SelS knock-down cells...
  3. Flack J, Mieszczanek J, Novcic N, Bienz M. Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5. Mol Cell. 2017;67:181-193.e5 pubmed publisher
    ..Thus, Groucho/TLE ubiquitylation by Hyd/UBR5 is a key prerequisite that enables Armadillo/β-catenin to activate transcription. ..
  4. Tawo R, Pokrzywa W, Kevei E, Akyuz M, Balaji V, Adrian S, et al. The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover. Cell. 2017;169:470-482.e13 pubmed publisher
    ..Our study indicates a competitive relationship between proteostasis and longevity regulation through CHIP-assisted proteolysis, providing a mechanistic concept for understanding the impact of proteome imbalance on aging. ..
  5. Collins G, Goldberg A. The Logic of the 26S Proteasome. Cell. 2017;169:792-806 pubmed publisher
  6. Wei Y, Diao L, Lu S, Wang H, Suo F, Dong M, et al. SUMO-Targeted DNA Translocase Rrp2 Protects the Genome from Top2-Induced DNA Damage. Mol Cell. 2017;66:581-596.e6 pubmed publisher
    ..Loss of Rrp2 enhances SUMOylation-dependent ubiquitination and degradation of Top2, which in turn increases DNA damage at sites where Top2-DNA complexes are trapped...
  7. Kanao R, Masutani C. Regulation of DNA damage tolerance in mammalian cells by post-translational modifications of PCNA. Mutat Res. 2017;803-805:82-88 pubmed publisher
    ..For example, TLS is mediated by mono-ubiquitination of PCNA at lysine 164, for which RAD6-RAD18 is the primary E2-E3 complex...
  8. Manthiram K, Zhou Q, Aksentijevich I, Kastner D. The monogenic autoinflammatory diseases define new pathways in human innate immunity and inflammation. Nat Immunol. 2017;18:832-842 pubmed publisher
    ..of the cytokine IL-1? to disorders arising from perturbations in signaling by the transcription factor NF-?B, ubiquitination, cytokine signaling, protein folding, type I interferon production and complement activation, and we further ..
  9. Liu H, Zhang L, Sun J, Chen W, Li S, Wang Q, et al. Endoplasmic Reticulum Protein SCAP Inhibits Dengue Virus NS2B3 Protease by Suppressing Its K27-Linked Polyubiquitylation. J Virol. 2017;91: pubmed publisher
    ..However, an endoplasmic reticulum (ER) protein, SCAP, through binding to NS2B protein, inhibits the ubiquitination of NS3, rendering NS2B3 protease incapable of binding and cleaving STING...

More Information

Publications113 found, 100 shown here

  1. Geng C, Kaochar S, Li M, Rajapakshe K, Fiskus W, Dong J, et al. SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein. Oncogene. 2017;36:4767-4777 pubmed publisher
    ..can physically interact with c-MYC protein and, upon exogenous expression in vitro, can promote c-MYC ubiquitination and degradation...
  2. Jia X, Zhou H, Wu C, Wu Q, Ma S, Wei C, et al. The Ubiquitin Ligase RNF125 Targets Innate Immune Adaptor Protein TRIM14 for Ubiquitination and Degradation. J Immunol. 2017;198:4652-4658 pubmed publisher
    ..RNF125 interacts with TRIM14 and acts as an E3 ubiquitin ligase that catalyzes TRIM14 ubiquitination. RNF125 promotes K48-linked polyubiquitination of TRIM14 and mediates its degradation via the ubiquitin-..
  3. Cheng Q, Yuan Y, Li L, Guo T, Miao Y, Ren Y, et al. Deubiquitinase USP33 is negatively regulated by ?-TrCP through ubiquitin-dependent proteolysis. Exp Cell Res. 2017;356:1-7 pubmed publisher
    ..Consequently, ?-TrCP attenuated USP33-mediated inhibition of cell proliferation and cell invasion. Taken together, our study clarified that the E3 ligase ?-TrCP regulates cellular USP33 levels by the ubiquitin-proteasomal proteolysis. ..
  4. Shibata N, Miyamoto N, Nagai K, Shimokawa K, Sameshima T, Ohoka N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017;108:1657-1666 pubmed publisher
    ..These results suggest that SNIPER(ABL)-39 could be a candidate for a degradation-based novel anti-cancer drug against BCR-ABL-positive CML. ..
  5. Flury V, Georgescu P, Iesmantavicius V, Shimada Y, Kuzdere T, Braun S, et al. The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1. Mol Cell. 2017;67:294-307.e9 pubmed publisher
    ..Brl1 acetylation increases histone H2B ubiquitination, which positively feeds back on transcription and prevents ectopic heterochromatin assembly...
  6. Niraj J, Caron M, Drapeau K, Bérubé S, Guitton Sert L, Coulombe Y, et al. The identification of FANCD2 DNA binding domains reveals nuclear localization sequences. Nucleic Acids Res. 2017;45:8341-8357 pubmed publisher
    ..Collectively, our results enlighten the importance of DNA binding and NLS residues in FANCD2 to activate an efficient FA pathway. ..
  7. Johnson N, Deck K, Nizzi C, Eisenstein R. A synergistic role of IRP1 and FBXL5 proteins in coordinating iron metabolism during cell proliferation. J Biol Chem. 2017;292:15976-15989 pubmed publisher
    ..We conclude that a regulatory circuit involving FBXL5 and CIA acts through both IRPs to control iron metabolism and promote optimal cell growth. ..
  8. Ren X, Wang J, Osada T, Mook R, Morse M, Barak L, et al. Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth. Breast Cancer Res. 2015;17:20 pubmed publisher
    ..The novel approach used here led to the discovery that perhexiline ablates HER3 expression, and offers an opportunity to identify HER3 ablation modulators as innovative therapeutics to improve survival in breast cancer patients. ..
  9. Workman J. CHROMATIN. It takes teamwork to modify chromatin. Science. 2016;351:667 pubmed publisher
  10. An T, Gong Y, Li X, Kong L, Ma P, Gong L, et al. USP7 inhibitor P5091 inhibits Wnt signaling and colorectal tumor growth. Biochem Pharmacol. 2017;131:29-39 pubmed publisher
    ..p53 status, and USP7 inhibition by its inhibitor P5091 attenuates the activity of Wnt signaling via enhanced ubiquitination and the subsequent degradation of ?-catenin...
  11. Zhang K, Wang J, Tong T, Wu X, Nelson R, Yuan Y, et al. Loss of H2B monoubiquitination is associated with poor-differentiation and enhanced malignancy of lung adenocarcinoma. Int J Cancer. 2017;141:766-777 pubmed publisher
    ..Taken together, our findings suggest that loss of H2Bub1 may enhance malignancy and promote disease progression in lung adenocarcinoma probably through modulating multiple cancer signaling pathways. ..
  12. Ishimoto K, Hayase A, Kumagai F, Kawai M, Okuno H, Hino N, et al. Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase. Biochem Biophys Res Commun. 2017;488:159-164 pubmed publisher
    ..These novel insights into the regulation of human Lipin-1 stability will be useful in planning further studies to elucidate its metabolic processes. ..
  13. Schunter S, Villa R, Flynn V, Heidelberger J, Classen A, Beli P, et al. Ubiquitylation of the acetyltransferase MOF in Drosophila melanogaster. PLoS ONE. 2017;12:e0177408 pubmed publisher
    ..Our study provides a comprehensive analysis of MOF ubiquitylation as a reference for future studies. ..
  14. Song Y, Li S, Ray A, Das D, Qi J, Samur M, et al. Blockade of deubiquitylating enzyme Rpn11 triggers apoptosis in multiple myeloma cells and overcomes bortezomib resistance. Oncogene. 2017;36:5631-5638 pubmed publisher
    ..Overall, our preclinical data provide the rationale for targeting DUB enzyme Rpn11 upstream of 20S proteasome to enhance cytotoxicity and overcome proteasome inhibitor resistance in MM...
  15. Janouskova H, El Tekle G, Bellini E, Udeshi N, Rinaldi A, Ulbricht A, et al. Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors. Nat Med. 2017;23:1046-1054 pubmed publisher
    ..Specifically, we provide a molecular rationale for the use of BET inhibitors to treat patients with endometrial but not prostate cancer who harbor SPOP mutations. ..
  16. Mezzadra R, Sun C, Jae L, Gomez Eerland R, de Vries E, Wu W, et al. Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Nature. 2017;549:106-110 pubmed publisher
    ..we demonstrate that CMTM6 is present at the cell surface, associates with the PD-L1 protein, reduces its ubiquitination and increases PD-L1 protein half-life...
  17. Fang R, Jiang Q, Zhou X, Wang C, Guan Y, Tao J, et al. MAVS activates TBK1 and IKK? through TRAFs in NEMO dependent and independent manner. PLoS Pathog. 2017;13:e1006720 pubmed publisher
    ..Moreover, individual TRAFs differently mediated TBK1/IKK? activation and thus fine-tuned antiviral immunity under physiological conditions. ..
  18. Sakamaki J, Fu A, Reeks C, Baird S, Depatie C, Al Azzabi M, et al. Role of the SIK2-p35-PJA2 complex in pancreatic ?-cell functional compensation. Nat Cell Biol. 2014;16:234-44 pubmed publisher
    ..This work demonstrates that the SIK2-p35-PJA2 complex is essential for glucose homeostasis and provides a link between p35-CDK5 and the AMPK family in excitable cells...
  19. Chen Z, Zhou Y, Zhang Z, Song J. Towards more accurate prediction of ubiquitination sites: a comprehensive review of current methods, tools and features. Brief Bioinform. 2015;16:640-57 pubmed publisher
    Protein ubiquitination is one of the most important reversible post-translational modifications (PTMs)...
  20. Park H, Go H, Song H, Kim S, Ha G, Jeon Y, et al. Pellino 1 promotes lymphomagenesis by deregulating BCL6 polyubiquitination. J Clin Invest. 2014;124:4976-88 pubmed publisher
    ..Together, these results suggest that increased PELI1 expression and subsequent induction of BCL6 promotes lymphomagenesis and that this pathway may be a potential target for therapeutic strategies to treat B cell lymphomas. ..
  21. Deshaies R. Protein degradation: Prime time for PROTACs. Nat Chem Biol. 2015;11:634-5 pubmed publisher
  22. Dubiel D, Bintig W, Kahne T, Dubiel W, Naumann M. Cul3 neddylation is crucial for gradual lipid droplet formation during adipogenesis. Biochim Biophys Acta Mol Cell Res. 2017;1864:1405-1412 pubmed publisher
    ..Downregulation of Cul3 led to a marked increase in RhoA protein expression after 6days of LiSa-2 cell differentiation, suggesting that Cul3 is involved in the regulation of RhoA stability. ..
  23. Zhu J, Li Y, Cao D, Yang H, Oh E, Bi Y, et al. The F-box Protein KIB1 Mediates Brassinosteroid-Induced Inactivation and Degradation of GSK3-like Kinases in Arabidopsis. Mol Cell. 2017;66:648-657.e4 pubmed publisher
    ..KIB1 directly interacted with BIN2 in a BR-dependent manner and promoted BIN2 ubiquitination in vitro...
  24. Toloczko A, Guo F, Yuen H, Wen Q, Wood S, Ong Y, et al. Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway. Cancer Res. 2017;77:4921-4933 pubmed publisher
    ..Recent studies have identified various E3 ubiquitin ligases that negatively regulate the Hippo pathway via ubiquitination, yet few deubiquitinating enzymes (DUB) have been implicated...
  25. Michel M, Swatek K, Hospenthal M, Komander D. Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling. Mol Cell. 2017;68:233-246.e5 pubmed publisher
    ..A protocol to enrich K6-ubiquitinated proteins from cells identifies HUWE1 as a main E3 ligase for this chain type, and we show that mitofusin-2 is modified with K6-linked polyubiquitin in a HUWE1-dependent manner. ..
  26. Yau R, Doerner K, Castellanos E, Haakonsen D, Werner A, Wang N, et al. Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control. Cell. 2017;171:918-933.e20 pubmed publisher
    ..By revealing key roles of K11/K48-linked chains in cell-cycle and quality control, we establish heterotypic ubiquitin conjugates as important carriers of biological information. ..
  27. He X, Li C, Ke R, Luo L, Huang D. Down-regulation of adenosine monophosphate-activated protein kinase activity: A driver of cancer. Tumour Biol. 2017;39:1010428317697576 pubmed publisher
    ..Here, we review the mechanisms by which AMPK is down-regulated in cancer. ..
  28. Kong L, Yin H, Yuan L. Centrosomal MCM7 strengthens the Cep68-VHL interaction and excessive MCM7 leads to centrosome splitting resulting from increase in Cep68 ubiquitination and proteasomal degradation. Biochem Biophys Res Commun. 2017;489:497-502 pubmed publisher
    ..As a result of MCM7 overexpression, Cep68 was targeted for ubiquitination and proteasomal degradation, thereby rendering centrosome splitting...
  29. Dong X, Liao W, Zhang L, Tu X, Hu J, Chen T, et al. RSPO2 suppresses colorectal cancer metastasis by counteracting the Wnt5a/Fzd7-driven noncanonical Wnt pathway. Cancer Lett. 2017;402:153-165 pubmed publisher
    ..The physical interaction of RSPO2 and Fzd7 increased the degradation of cell surface Fzd7 via ZNRF3-mediated ubiquitination, which led to the suppression of the downstream PKC/ERK signaling cascade...
  30. Su C, Liu Z, Wang Y, Wang Y, Song E, Song Y. The electrophilic character of quinones is essential for the suppression of Bach1. Toxicology. 2017;387:17-26 pubmed publisher
    ..Taking together, our investigation illustrated that the electrophilic character of quinones ensure their conjugation with Bach1, which is important for the downregulation of Bach1 and the upregulation of Nrf2 signaling. ..
  31. Sisinni L, Maddalena F, Condelli V, Pannone G, Simeon V, Li Bergolis V, et al. TRAP1 controls cell cycle G2-M transition through the regulation of CDK1 and MAD2 expression/ubiquitination. J Pathol. 2017;243:123-134 pubmed publisher
    ..TRAP1 modulates the expression and/or the ubiquitination of key cell cycle regulators through a dual mechanism: (i) transcriptional regulation of CDK1, CYCLIN B1, and ..
  32. Wang V, Li Y, Kim D, Zhong X, Du Q, Ghassemian M, et al. Bcl3 Phosphorylation by Akt, Erk2, and IKK Is Required for Its Transcriptional Activity. Mol Cell. 2017;67:484-497.e5 pubmed publisher
    ..Phosphorylation of Ser33 by Akt induces switching of K48 ubiquitination to K63 ubiquitination and thus promotes nuclear localization and stabilization of Bcl3...
  33. Park J, Byrd A, Lee C, Morgan E. Nitric oxide stimulates cellular degradation of human CYP51A1, the highly conserved lanosterol 14?-demethylase. Biochem J. 2017;474:3241-3252 pubmed publisher
    ..This down-regulation was partially attenuated by proteasome inhibitors, but only trace levels of ubiquitination could be found...
  34. Kevei E, Hoppe T. Ubiquitin sets the timer: impacts on aging and longevity. Nat Struct Mol Biol. 2014;21:290-2 pubmed publisher
  35. Branicky R, Hekimi S. Proteostasis or Aging: Let the CHIPs Fall Where They May. Dev Cell. 2017;41:126-128 pubmed publisher
    ..2017) show that CHIP/CHN-1 also directly ubiquitylates the insulin receptor INSR/DAF-2 to regulate its turnover. These findings suggest an unexpected interpretation of the effects of altered proteostasis on survival. ..
  36. Zhu W, He X, Hua Y, Li Q, Wang J, Gan X. The E3 ubiquitin ligase WWP2 facilitates RUNX2 protein transactivation in a mono-ubiquitination manner during osteogenic differentiation. J Biol Chem. 2017;292:11178-11188 pubmed publisher
    Poly-ubiquitination-mediated RUNX2 degradation is an important cause of age- and inflammation-related bone loss. NEDD4 family E3 ubiquitin protein ligases are thought to be the major regulators of RUNX2 poly-ubiquitination...
  37. Paul A, Wang B. RNF8- and Ube2S-Dependent Ubiquitin Lysine 11-Linkage Modification in Response to DNA Damage. Mol Cell. 2017;66:458-472.e5 pubmed publisher
    ..Thus, our study highlights the importance of linkage-specific ubiquitination at DNA damage sites, and it reveals that Lys11-linkage ubiquitin modification plays a crucial role in the DNA ..
  38. Weber A, Elliott P, Pinto Fernandez A, Bonham S, Kessler B, Komander D, et al. A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN. Cell Chem Biol. 2017;24:1299-1313.e7 pubmed publisher
    ..Thus, we present a highly selective ABP for OTULIN that will facilitate studying the cellular function of this essential DUB. ..
  39. Chen F, Zhang C, Wu H, Ma Y, Luo X, Gong X, et al. The E3 ubiquitin ligase SCFFBXL14 complex stimulates neuronal differentiation by targeting the Notch signaling factor HES1 for proteolysis. J Biol Chem. 2017;292:20100-20112 pubmed publisher
    ..Based on siRNA-mediated gene silencing screening, co-immunoprecipitation, and ubiquitination assays, we discovered that the E3 ubiquitin ligase SCFFBXL14 complex regulates HES1 ubiquitination ..
  40. Alvaro C, O Donnell A, Prosser D, Augustine A, Goldman A, Brodsky J, et al. Specific ?-arrestins negatively regulate Saccharomyces cerevisiae pheromone response by down-modulating the G-protein-coupled receptor Ste2. Mol Cell Biol. 2014;34:2660-81 pubmed
    ..Finally, we show that Rod1 function requires calcineurin-dependent dephosphorylation. ..
  41. Zhang X, Zhao F, Zhang S, Song Y. Ectopic High Expression of E2-EPF Ubiquitin Carrier Protein Indicates a More Unfavorable Prognosis in Brain Glioma. Genet Test Mol Biomarkers. 2017;21:242-247 pubmed publisher
    b>Ubiquitination of proteins meant for elimination is a primary method of eukaryotic cellular protein degradation. The ubiquitin carrier protein E2-EPF is a key degradation enzyme that is highly expressed in many tumors...
  42. Williamson R, Laulagnier K, Miranda A, Fernandez M, Wolfe M, Sadoul R, et al. Disruption of amyloid precursor protein ubiquitination selectively increases amyloid ? (A?) 40 levels via presenilin 2-mediated cleavage. J Biol Chem. 2017;292:19873-19889 pubmed publisher
    ..Among various post-translational modifications affecting APP accumulation, ubiquitination of cytodomain lysines may represent a key signal controlling APP endosomal sorting...
  43. Kazi J, Chougule R, Li T, Su X, Moharram S, Rupar K, et al. Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD. Cell Mol Life Sci. 2017;74:2679-2688 pubmed publisher
    ..In this report, we show that Y842 is not important for FLT3 activation or ubiquitination but plays a critical role in regulating signaling downstream of the receptor as well as controlling receptor ..
  44. Trimpert C, Wesche D, de Groot T, Pimentel Rodriguez M, Wong V, van den Berg D, et al. NDFIP allows NEDD4/NEDD4L-induced AQP2 ubiquitination and degradation. PLoS ONE. 2017;12:e0183774 pubmed publisher
    ..to the apical membrane, this is counteracted by protein kinase C-activating hormones, resulting in ubiquitination-dependent internalization of AQP2. The proteins targeting AQP2 for ubiquitin-mediated degradation are unknown...
  45. Zhu D, Li C, Swanson A, Villalba R, Guo J, Zhang Z, et al. BAI1 regulates spatial learning and synaptic plasticity in the hippocampus. J Clin Invest. 2015;125:1497-508 pubmed publisher
    ..Moreover, these results suggest that targeting this pathway has therapeutic potential for a variety of neurological disorders. ..
  46. Wang B, Jie Z, Joo D, Ordureau A, Liu P, Gan W, et al. TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling. Nature. 2017;545:365-369 pubmed publisher
    ..Moreover, loss of critical ubiquitination residues in G?L, by either K305R/K313R mutations or a melanoma-associated G?L(?W297) truncation, leads to ..
  47. Reventun P, Alique M, Cuadrado I, Marquez S, Toro R, Zaragoza C, et al. iNOS-Derived Nitric Oxide Induces Integrin-Linked Kinase Endocytic Lysosome-Mediated Degradation in the Vascular Endothelium. Arterioscler Thromb Vasc Biol. 2017;37:1272-1281 pubmed publisher
    ..Mechanistically, NO increased ILK ubiquitination mediated by the E3 ubiquitin ligase CHIP (C terminus of HSC70-interacting protein), but ILK ubiquitination was ..
  48. Kesavardhana S, Kuriakose T, Guy C, Samir P, Malireddi R, Mishra A, et al. ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death. J Exp Med. 2017;214:2217-2229 pubmed publisher
    ..IAV infection induces ubiquitination of ZBP1, suggesting potential regulation of ZBP1 function through posttranslational modifications...
  49. Goto Y, Koyasu S, Kobayashi M, Harada H. The emerging roles of the ubiquitination/deubiquitination system in tumor radioresistance regarding DNA damage responses, cell cycle regulation, hypoxic responses, and antioxidant properties: Insight into the development of novel radiosensitizing str. Mutat Res. 2017;803-805:76-81 pubmed publisher
    ..the various biological processes known to induce radioresistance, a post-translational protein modification, ubiquitination, has received marked attention in recent years...
  50. Kouzarides T. SnapShot: Histone-modifying enzymes. Cell. 2007;128:802 pubmed
  51. Engel E, Viargues P, Mortier M, Taillebourg E, Coute Y, Thevenon D, et al. Identifying USPs regulating immune signals in Drosophila: USP2 deubiquitinates Imd and promotes its degradation by interacting with the proteasome. Cell Commun Signal. 2014;12:41 pubmed publisher
    ..This study provides original information for the better understanding of the strong implication of USP2 in pathological processes in humans, including cancerogenesis. ..
  52. Tan T, Zimmermann M, Reichert A. Controlling quality and amount of mitochondria by mitophagy: insights into the role of ubiquitination and deubiquitination. Biol Chem. 2016;397:637-47 pubmed publisher
    ..Earlier studies showed that ubiquitination and deubiquitination occurs in yeast, yet there is no direct evidence for an ubiquitin-dependent mitophagy ..
  53. Zhang C, Chen Y, Gan X, Huang Z, Zou M, Fu W, et al. SAK-HV Decreases the Self-Ubiquitination of MEKK1 to Promote Macrophage Proliferation via MAPK/ERK and JNK Pathways. Int J Mol Sci. 2017;18: pubmed publisher
    ..Thus, we postulated an attractive model of ubiquitination, in which the interactions between Uba1 and specific E2 enzymes are blocked by its interaction with SAK-HV...
  54. Qiu J, Luo Z. Legionella and Coxiella effectors: strength in diversity and activity. Nat Rev Microbiol. 2017;15:591-605 pubmed publisher
    ..pneumophila and C. burnetii as key virulence factors, and we examine the biochemical and cell biological functions of these effectors and their roles in our understanding of bacterial virulence. ..
  55. Jacque E, Ley S. RNF11, a new piece in the A20 puzzle. EMBO J. 2009;28:455-6 pubmed publisher
  56. Wojcik C, Lohe K, Kuang C, Xiao Y, Jouni Z, Poels E. Modulation of adipocyte differentiation by omega-3 polyunsaturated fatty acids involves the ubiquitin-proteasome system. J Cell Mol Med. 2014;18:590-9 pubmed
    ..Moreover, all three ?-3 PUFAs appear to induce tumour necrosis factor-? without affecting NF?B levels. All three ?-3 PUFAs appear to have overall similar effects. Further research is needed to elucidate their mechanism of action. ..
  57. Yu T, Zhang Y, Li P. Mitochondrial Ubiquitin Ligase in Cardiovascular Disorders. Adv Exp Med Biol. 2017;982:327-333 pubmed publisher
    ..In this chapter, we provide a comprehensive overview of the functions of mitochondrial ubiquitin ligases identified hitherto, with a special focus on cardiovascular disorders. ..
  58. Nivison M, Ericson N, Green V, Bielas J, Campbell J, Horner P. Age-related accumulation of phosphorylated mitofusin 2 protein in retinal ganglion cells correlates with glaucoma progression. Exp Neurol. 2017;296:49-61 pubmed publisher
    ..Phosphorylation of Mfn2 is correlated with higher ubiquitination, and failure of the protein to reach the ON...
  59. Nihira N, Ogura K, Shimizu K, North B, Zhang J, Gao D, et al. Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function. Sci Signal. 2017;10: pubmed publisher
    ..acetyltransferase p300-mediated acetylation and stabilization of MDM2 are molecular switches that block self-ubiquitination, thereby shifting its E3 ligase activity toward p53...
  60. Thomas E. Histone Posttranslational Modifications in Schizophrenia. Adv Exp Med Biol. 2017;978:237-254 pubmed publisher
    ..This chapter will review the current information regarding histone modifications in schizophrenia and the potential therapeutic relevance of such marks. ..
  61. Kushwaha N, Bhardwaj M, Chakraborty S. The replication initiator protein of a geminivirus interacts with host monoubiquitination machinery and stimulates transcription of the viral genome. PLoS Pathog. 2017;13:e1006587 pubmed publisher
  62. González López L, Carballar Lejarazu R, Arrevillaga Boni G, Cortes Martinez L, Cázares Raga F, Trujillo Ocampo A, et al. Lys48 ubiquitination during the intraerythrocytic cycle of the rodent malaria parasite, Plasmodium chabaudi. PLoS ONE. 2017;12:e0176533 pubmed publisher
    b>Ubiquitination tags proteins for different functions within the cell. One of the most abundant and studied ubiquitin modification is the Lys48 polyubiquitin chain that modifies proteins for their destruction by proteasome...
  63. Dogan T, Gnad F, Chan J, Phu L, Young A, Chen M, et al. Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle. J Biol Chem. 2017;292:14311-14324 pubmed publisher
    ..We demonstrate that RNF157 phosphorylation downstream of the PI3K and MAPK pathways influences the ubiquitination and stability of RNF157 during the cell cycle in an anaphase-promoting complex/cyclosome-CDH1-dependent manner...
  64. Nishi R. Balancing act: To be, or not to be ubiquitylated. Mutat Res. 2017;803-805:43-50 pubmed publisher
    ..An advanced understanding of the detailed molecular mechanisms of the "balancing act" between ubiquitylation and deubiquitylation will provide novel therapeutic targets for diseases caused by dysfunction of DDR and DSB repair. ..
  65. Kampmeyer C, Karakostova A, Schenstrøm S, Abildgaard A, Lauridsen A, Jourdain I, et al. The exocyst subunit Sec3 is regulated by a protein quality control pathway. J Biol Chem. 2017;292:15240-15253 pubmed publisher
    ..In conclusion, our results suggest that a cytosolic protein quality control pathway monitors folding and proteasome-dependent turnover of an exocyst subunit and, thereby, controls exocytosis in fission yeast. ..
  66. Meshram S, Paul D, Manne R, Choppara S, Sankaran G, Agrawal Y, et al. FBXO32 activates NF-κB through IκBα degradation in inflammatory and genotoxic stress. Int J Biochem Cell Biol. 2017;92:134-140 pubmed publisher
    ..We also found that FBXO32 is required for physiological regulation of IκBα levels in unstressed cells. Thus, we decipher the new role of FBXO32 in regulation of NF-κB signaling pathway. ..
  67. Kouranti I, McLean J, Feoktistova A, Liang P, Johnson A, Roberts Galbraith R, et al. A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity. PLoS Biol. 2010;8: pubmed publisher
    b>Ubiquitination and deubiquitination are reciprocal processes that tune protein stability, function, and/or localization...
  68. Weathington N, Mallampalli R. Emerging therapies targeting the ubiquitin proteasome system in cancer. J Clin Invest. 2014;124:6-12 pubmed publisher
    ..In this article, we discuss the biology of UPS-targeting drugs, their use as therapy for neoplasia, and the state of clinical and preclinical development for emerging therapeutics. ..
  69. Hovsepian J, Defenouillère Q, Albanèse V, Váchová L, García C, Palková Z, et al. Multilevel regulation of an α-arrestin by glucose depletion controls hexose transporter endocytosis. J Cell Biol. 2017;216:1811-1831 pubmed publisher
    ..Thus, two glucose signaling pathways converge onto Csr2 to regulate hexose transporter endocytosis by glucose availability. These data illustrate novel mechanisms by which nutrients modulate ART activity and endocytosis. ..
  70. Wald J, Hatakeyama J, Printsev I, Cuevas A, Fry W, Saldana M, et al. Suppression of planar cell polarity signaling and migration in glioblastoma by Nrdp1-mediated Dvl polyubiquitination. Oncogene. 2017;36:5158-5167 pubmed publisher
    ..b>Ubiquitination hinders Dvl binding to phosphatidic acid, an interaction necessary for efficient Dvl recruitment to the plasma ..
  71. Dai X, Gan W, Li X, Wang S, Zhang W, Huang L, et al. Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. Nat Med. 2017;23:1063-1071 pubmed publisher
    ..Here we report that cullin-3SPOP earmarks BET proteins, including BRD2, BRD3 and BRD4, for ubiquitination-mediated degradation...
  72. Frank E, McLenigan M, McDonald J, Huston D, Mead S, Woodgate R. DNA polymerase ι: The long and the short of it!. DNA Repair (Amst). 2017;58:47-51 pubmed publisher
  73. Carmody M, Notarianni T, Sambel L, Walsh S, Burke J, Armstrong J, et al. E6AP/UBE3A catalyzes encephalomyocarditis virus 3C protease polyubiquitylation and promotes its concentration reduction in virus-infected cells. Biochem Biophys Res Commun. 2017;494:63-69 pubmed publisher
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    ..a positive regulator of ciliogenesis, is a stable and low turnover protein subjected to cycles of ubiquitination and deubiquitination...
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    b>Ubiquitination is a multifunctional posttranslational modification controlling the activity, subcellular localization and stability of proteins...
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    ..USP14 could bind to AR, and additionally, both genetic and pharmacological inhibition of USP14 accelerated the ubiquitination and degradation of AR; (ii) downregulation or inhibition of USP14 suppressed cell proliferation and colony ..
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    ..the ligand stimulates the recruitment of SMURF2 to the c-SKI-SMAD2 complex and triggers c-SKI ubiquitination and degradation. Thus, SMURF2 has a role in termination and initiation of TGF-? family signaling...