epigenetic repression


Summary: The turning off of GENETIC TRANSCRIPTION in certain regions of CHROMATIN without changes in the DNA sequence. Typically epigenetic repression is a way that developmental changes are programmed at the cellular level.

Top Publications

  1. Akkouche A, Mugat B, Barckmann B, Varela Chavez C, Li B, Raffel R, et al. Piwi Is Required during Drosophila Embryogenesis to License Dual-Strand piRNA Clusters for Transposon Repression in Adult Ovaries. Mol Cell. 2017;66:411-419.e4 pubmed publisher
  2. Guler G, Tindell C, Pitti R, Wilson C, Nichols K, KaiWai Cheung T, et al. Repression of Stress-Induced LINE-1 Expression Protects Cancer Cell Subpopulations from Lethal Drug Exposure. Cancer Cell. 2017;32:221-237.e13 pubmed publisher
    ..Disruption of the repressive chromatin over LINE-1 elements in DTPs results in DTP ablation, which is partially rescued by reducing LINE-1 expression or function. ..
  3. Byun S, Kim Y, Zhang Y, Kong B, Guo G, Sadoshima J, et al. A postprandial FGF19-SHP-LSD1 regulatory axis mediates epigenetic repression of hepatic autophagy. EMBO J. 2017;36:1755-1769 pubmed publisher
    ..Here, we show that Small Heterodimer Partner (SHP) mediates postprandial epigenetic repression of hepatic autophagy by recruiting histone demethylase LSD1 in response to a late fed-state hormone, FGF19 ..
  4. Xia L, Huang W, Bellani M, Seidman M, Wu K, Fan D, et al. CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes. Cancer Cell. 2017;31:653-668.e7 pubmed publisher
    ..High CHD4 and 8-OHdG levels plus low expression of TSGs strongly correlates with early disease recurrence and decreased overall survival. ..
  5. Brocks D, Schmidt C, Daskalakis M, Jang H, Shah N, Li D, et al. DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats. Nat Genet. 2017;49:1052-1060 pubmed publisher
  6. Saha D, Singh A, Hussain T, Srivastava V, Sengupta S, Kar A, et al. Epigenetic suppression of human telomerase (hTERT) is mediated by the metastasis suppressor NME2 in a G-quadruplex-dependent fashion. J Biol Chem. 2017;292:15205-15215 pubmed publisher
    ..Together, our results support a mechanism of hTERT epigenetic control involving a G-quadruplex promoter motif, which potentially can be targeted by tailored small molecules. ..
  7. Szabad J. [Pre-programmed genes]. Orv Hetil. 2017;158:1323-1330 pubmed publisher
    ..It summarizes how genetic crosses reveal the involvement of epigenesis, explains its meaning and impact on life of the organisms. An understanding of epigenesis provides guidance to improve our life. Orv Hetil. 2017; 158(34): 1323-1330. ..
  8. Berry S, Rosa S, Howard M, Buhler M, Dean C. Disruption of an RNA-binding hinge region abolishes LHP1-mediated epigenetic repression. Genes Dev. 2017;31:2115-2120 pubmed publisher
    ..Disruption of the RNA-binding hinge region also prevented formation of subnuclear foci, structures potentially important for epigenetic repression.
  9. Wu Y, Cao C, Wu Y, Li M, Lai T, Zhu C, et al. Activating transcription factor 3 represses cigarette smoke-induced IL6 and IL8 expression via suppressing NF-?B activation. Toxicol Lett. 2017;270:17-24 pubmed publisher
    ..Thus, this study shows that ATF3 plays an important role in the negative regulation of CS-induced pro-inflammatory gene expression through downregulating NF-?B phosphorylation. ..

More Information


  1. Antony A C, Alone P. Defect in the GTPase activating protein (GAP) function of eIF5 causes repression of GCN4 translation. Biochem Biophys Res Commun. 2017;486:1110-1115 pubmed publisher
  2. Tatekawa S, Chinen Y, Ri M, Narita T, Shimura Y, Matsumura Kimoto Y, et al. Epigenetic repression of miR-375 is the dominant mechanism for constitutive activation of the PDPK1/RPS6KA3 signalling axis in multiple myeloma. Br J Haematol. 2017;178:534-546 pubmed publisher
  3. Tchasovnikarova I, Timms R, Douse C, Roberts R, Dougan G, Kingston R, et al. Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2. Nat Genet. 2017;49:1035-1044 pubmed publisher
    ..These data define a critical role for MORC2 in epigenetic silencing by the HUSH complex and provide a mechanistic basis underpinning the role of MORC2 mutations in CMT disease. ..
  4. Xiao J, Jin R, Yu X, Shen M, Wagner J, Pai A, et al. Cis and trans determinants of epigenetic silencing by Polycomb repressive complex 2 in Arabidopsis. Nat Genet. 2017;49:1546-1552 pubmed publisher
    ..Thus PRC2 recruitment in Arabidopsis relies in large part on binding of trans-acting factors to cis-localized DNA sequence motifs. ..
  5. Jain D, Meydan C, Lange J, Claeys Bouuaert C, Lailler N, Mason C, et al. rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline. PLoS Genet. 2017;13:e1006964 pubmed publisher
    ..These findings provide insight into the evolutionary dynamics and functional specialization of the transposon suppression machinery critical for mammalian sexual reproduction and epigenetic regulation. ..