Summary: The turning off of GENETIC TRANSCRIPTION in certain regions of CHROMATIN without changes in the DNA sequence. Typically epigenetic repression is a way that developmental changes are programmed at the cellular level.
Akkouche A, Mugat B, Barckmann B, Varela Chavez C, Li B, Raffel R, et al
. Piwi Is Required during Drosophila Embryogenesis to License Dual-Strand piRNA Clusters for Transposon Repression in Adult Ovaries. Mol Cell. 2017;66:411-419.e4 pubmed publisher
Guler G, Tindell C, Pitti R, Wilson C, Nichols K, KaiWai Cheung T, et al
. Repression of Stress-Induced LINE-1 Expression Protects Cancer Cell Subpopulations from Lethal Drug Exposure. Cancer Cell. 2017;32:221-237.e13 pubmed publisher
..Disruption of the repressive chromatin over LINE-1 elements in DTPs results in DTP ablation, which is partially rescued by reducing LINE-1 expression or function. ..
Byun S, Kim Y, Zhang Y, Kong B, Guo G, Sadoshima J, et al
. A postprandial FGF19-SHP-LSD1 regulatory axis mediates epigenetic repression of hepatic autophagy. EMBO J. 2017;36:1755-1769 pubmed publisher
..Here, we show that Small Heterodimer Partner (SHP) mediates postprandial epigenetic repression of hepatic autophagy by recruiting histone demethylase LSD1 in response to a late fed-state hormone, FGF19 ..
Xia L, Huang W, Bellani M, Seidman M, Wu K, Fan D, et al
. CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes. Cancer Cell. 2017;31:653-668.e7 pubmed publisher
..High CHD4 and 8-OHdG levels plus low expression of TSGs strongly correlates with early disease recurrence and decreased overall survival. ..
Brocks D, Schmidt C, Daskalakis M, Jang H, Shah N, Li D, et al
. DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats. Nat Genet. 2017;49:1052-1060 pubmed publisher
Saha D, Singh A, Hussain T, Srivastava V, Sengupta S, Kar A, et al
. Epigenetic suppression of human telomerase (hTERT) is mediated by the metastasis suppressor NME2 in a G-quadruplex-dependent fashion. J Biol Chem. 2017;292:15205-15215 pubmed publisher
..Together, our results support a mechanism of hTERT epigenetic control involving a G-quadruplex promoter motif, which potentially can be targeted by tailored small molecules. ..
Szabad J. [Pre-programmed genes]. Orv Hetil. 2017;158:1323-1330 pubmed publisher
..It summarizes how genetic crosses reveal the involvement of epigenesis, explains its meaning and impact on life of the organisms. An understanding of epigenesis provides guidance to improve our life. Orv Hetil. 2017; 158(34): 1323-1330. ..
Berry S, Rosa S, Howard M, Buhler M, Dean C. Disruption of an RNA-binding hinge region abolishes LHP1-mediated epigenetic repression. Genes Dev. 2017;31:2115-2120 pubmed publisher
..Disruption of the RNA-binding hinge region also prevented formation of subnuclear foci, structures potentially important for epigenetic repression.
Wu Y, Cao C, Wu Y, Li M, Lai T, Zhu C, et al
. Activating transcription factor 3 represses cigarette smoke-induced IL6 and IL8 expression via suppressing NF-?B activation. Toxicol Lett. 2017;270:17-24 pubmed publisher
..Thus, this study shows that ATF3 plays an important role in the negative regulation of CS-induced pro-inflammatory gene expression through downregulating NF-?B phosphorylation. ..