catabolite repression


Summary: Process by which micro-organisms adapt quickly to a preferred rapidly-metabolizable intermediate through the inhibition or repression of genes related to CATABOLISM of less preferred source(s).

Top Publications

  1. Lo Scrudato M, Borgeaud S, Blokesch M. Regulatory elements involved in the expression of competence genes in naturally transformable Vibrio cholerae. BMC Microbiol. 2014;14:327 pubmed publisher at least three pathways in this organism: chitin sensing/degradation, quorum sensing and carbon catabolite repression (CCR)...
  2. Kayikci Ã, Nielsen J. Glucose repression in Saccharomyces cerevisiae. FEMS Yeast Res. 2015;15: pubmed publisher
    ..This review describes effects of glucose repression on yeast carbon metabolism with a focus on roles of the Snf3/Rgt2 glucose-sensing pathway and Snf1 signal transduction in establishment and relief of glucose repression. ..
  3. Beattie S, Mark K, Thammahong A, Ries L, Dhingra S, Caffrey Carr A, et al. Filamentous fungal carbon catabolite repression supports metabolic plasticity and stress responses essential for disease progression. PLoS Pathog. 2017;13:e1006340 pubmed publisher
    ..To this end, we find that A. fumigatus requires a carbon catabolite repression (CCR) mediated genetic network to support in vivo fungal fitness and disease progression...
  4. Merran J, Corden J. Yeast RNA-Binding Protein Nab3 Regulates Genes Involved in Nitrogen Metabolism. Mol Cell Biol. 2017;37: pubmed publisher
    ..As expected, many noncoding RNAs fail to terminate properly. In addition, we observe that nitrogen catabolite-repressed genes are upregulated by Nab3 depletion. ..