dna breaks


Summary: Interruptions in the sugar-phosphate backbone of DNA.

Top Publications

  1. Kodaira M, Asakawa J, Nakamura N. Radiation-Induced Deletions in Mouse Spermatogonia are Usually Large (over 200 kb) and Contain Little Sequence Similarity at the Junctions. Radiat Res. 2017;187:722-731 pubmed publisher
    ..These results indicate that large size (>200 kb) and little sequence similarity around the rejoined sites are likely to be a hallmark of radiation-induced deletions in mice. ..
  2. Barreto A, Luis L, Soares A, Paíga P, Santos L, Delerue Matos C, et al. Genotoxicity of gemfibrozil in the gilthead seabream (Sparus aurata). Mutat Res. 2017;821:36-42 pubmed publisher
    ..Gemfibrozil was positive in both endpoints, at environmentally relevant concentrations, a result that raises concerns about the potential genotoxic effects of the drug in recipient waters. ..
  3. Wang Y, Chen S, Wu C, Liao Y, Lin T, Liu K, et al. Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry. Nucleic Acids Res. 2017;45:10861-10871 pubmed publisher
    ..The potency of these drugs correlates positively with their efficacy in stabilizing the enzyme-mediated DNA breaks. Structural analysis of hTop2? and hTop2? revealed the presence of methionine residues in the drug-binding ..
  4. Hauser P, Wang S, Didenko V. Apoptotic Bodies: Selective Detection in Extracellular Vesicles. Methods Mol Biol. 2017;1554:193-200 pubmed publisher
    ..The approach exclusively labels the vesicles that contain DNA with 5'PO4 blunt-ended DNA breaks, such as those produced by the apoptotic CAD nuclease during apoptotic DNA degradation...
  5. Aguilera A, Gómez González B. DNA-RNA hybrids: the risks of DNA breakage during transcription. Nat Struct Mol Biol. 2017;24:439-443 pubmed publisher
    ..Emerging evidence indicates that DNA breaks stimulate DNA-RNA hybrid formation...
  6. Cuya S, Bjornsti M, van Waardenburg R. DNA topoisomerase-targeting chemotherapeutics: what's new?. Cancer Chemother Pharmacol. 2017;80:1-14 pubmed publisher
    ..of DNA molecules are regulated by topoisomerases through the introduction of transient enzyme-linked DNA breaks. The covalent topoisomerase-DNA complexes are the cellular targets of a diverse group of cancer ..
  7. Price B. KDM5A demethylase: Erasing histone modifications to promote repair of DNA breaks. J Cell Biol. 2017;216:1871-1873 pubmed publisher
    Repairing DNA breaks within the complexity of the cell chromatin is challenging. In this issue, Gong et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb...
  8. Garzón J, Rodríguez R, Kong Z, Chabes A, Rodríguez Acebes S, Méndez J, et al. Shortage of dNTPs underlies altered replication dynamics and DNA breakage in the absence of the APC/C cofactor Cdh1. Oncogene. 2017;36:5808-5818 pubmed publisher
    ..These observations highlight the relevance of APC/C-Cdh1 activity during G1 to ensure an adequate supply of dNTPs to the replisome, prevent replication stress and the resulting chromosomal breaks and, ultimately, suppress tumorigenesis. ..
  9. Wang G, Deng S, Liu J, Ye C, Zhou X, Chen L. Cell damage caused by ultraviolet B radiation in the desert cyanobacterium Phormidium tenue and its recovery process. Ecotoxicol Environ Saf. 2017;144:315-320 pubmed publisher
    ..These chemicals could aid in the resistance of P. tenue to the exposure of intense UV-B radiation in desertified areas when inoculated onto the sand surface to form artificial algal crusts. ..

More Information


  1. Taglialatela A, Alvarez S, Leuzzi G, Sannino V, Ranjha L, Huang J, et al. Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers. Mol Cell. 2017;68:414-430.e8 pubmed publisher
    ..stalled forks, restores replication fork stability and reduces the formation of replication stress-induced DNA breaks and chromosomal aberrations in BRCA1/2-deficient cells...
  2. Śladowska K, Opydo Chanek M, Król T, Trybus W, Trybus E, Kopacz Bednarska A, et al. In Vitro Effects of Bromoalkyl Phenytoin Derivatives on Regulated Death, Cell Cycle and Ultrastructure of Leukemia Cells. Anticancer Res. 2017;37:6373-6380 pubmed
  3. Utani K, Fu H, Jang S, Marks A, Smith O, Zhang Y, et al. Phosphorylated SIRT1 associates with replication origins to prevent excess replication initiation and preserve genomic stability. Nucleic Acids Res. 2017;45:7807-7824 pubmed publisher
    ..These observations suggest that SIRT1 phosphorylation modulates the distribution of replication initiation events to insure genomic stability. ..
  4. Kellner S, DeMott M, Cheng C, Russell B, Cao B, You D, et al. Oxidation of phosphorothioate DNA modifications leads to lethal genomic instability. Nat Chem Biol. 2017;13:888-894 pubmed publisher
    ..The genotoxicity of HOCl in PT-containing bacteria suggests reduced fitness in competition with HOCl-producing organisms and during infections in humans. ..
  5. Singh G, Da Ines O, Gallego M, White C. Analysis of the impact of the absence of RAD51 strand exchange activity in Arabidopsis meiosis. PLoS ONE. 2017;12:e0183006 pubmed publisher
    ..has however shown that in the absence of RAD51 strand-exchange activity, DMC1 is able to repair all meiotic DNA breaks and surprisingly, that this does not appear to affect numbers of meiotic cross-overs...
  6. Tiwari A, Addis Jones O, Chan K. 53BP1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine DNA bridging-breakage process. Nat Commun. 2018;9:677 pubmed publisher
    ..Therefore, our study reveals a hitherto unreported chromatid damage phenomenon mediated by sister DNA intertwinements that may help to explain the development of complex karyotypes in tumour cells. ..