cytokinesis

Summary

Summary: The process by which the CYTOPLASM of a cell is divided.

Top Publications

  1. Lee Y, Chung S, Baek I, Lee T, Paik S, Lee J. UNC119a bridges the transmission of Fyn signals to Rab11, leading to the completion of cytokinesis. Cell Cycle. 2013;12:1303-15 pubmed publisher
    Src family kinases (SFKs) regulate the completion of cytokinesis through signal transduction pathways that lead to the Rab11-dependent phosphorylation of ERK and its localization to the midbody of cytokinetic cells...
  2. Rincon S, Paoletti A. Mid1/anillin and the spatial regulation of cytokinesis in fission yeast. Cytoskeleton (Hoboken). 2012;69:764-77 pubmed publisher
    ..for cell division studies has allowed a detailed molecular understanding of the spatial mechanisms regulating cytokinesis. Division plane position in this unicellular rod-shaped organism, which divides by the assembly and ..
  3. Tse Y, Werner M, Longhini K, Labbé J, Goldstein B, Glotzer M. RhoA activation during polarization and cytokinesis of the early Caenorhabditis elegans embryo is differentially dependent on NOP-1 and CYK-4. Mol Biol Cell. 2012;23:4020-31 pubmed publisher
    ..During cytokinesis, RhoA is activated by the RhoGEF ECT-2...
  4. Wloka C, Bi E. Mechanisms of cytokinesis in budding yeast. Cytoskeleton (Hoboken). 2012;69:710-26 pubmed publisher
    b>Cytokinesis is essential for cell proliferation in all domains of life...
  5. Meitinger F, Richter H, Heisel S, Hub B, Seufert W, Pereira G. A safeguard mechanism regulates Rho GTPases to coordinate cytokinesis with the establishment of cell polarity. PLoS Biol. 2013;11:e1001495 pubmed publisher
    ..that concomitantly sustains Rho1-dependent polarization and inhibits premature Cdc42 activation at the site of cytokinesis. Failure of Gps1 regulation leads to daughter cell death due to rebudding inside the old bud site...
  6. Karakaya K, Herbst F, Ball C, Glimm H, Krämer A, Loffler H. Overexpression of EVI1 interferes with cytokinesis and leads to accumulation of cells with supernumerary centrosomes in G0/1 phase. Cell Cycle. 2012;11:3492-503 pubmed publisher
    ..Live cell imaging experiments identified cytokinesis failure as the underlying cause of this phenotype...
  7. Zhu Y, Ye Y, Wu Z, Wu J. Cooperation between Rho-GEF Gef2 and its binding partner Nod1 in the regulation of fission yeast cytokinesis. Mol Biol Cell. 2013;24:3187-204 pubmed publisher
    b>Cytokinesis is the last step of the cell-division cycle, which requires precise spatial and temporal regulation to ensure genetic stability...
  8. Hofmann T, Glas C, Bitomsky N. HIPK2: A tumour suppressor that controls DNA damage-induced cell fate and cytokinesis. Bioessays. 2013;35:55-64 pubmed publisher
    ..Recent work has identified HIPK2 as a regulator of the ultimate step in cytokinesis: the abscission of the mother and daughter cells...
  9. Nkosi P, Targosz B, Labib K, Sanchez Diaz A. Hof1 and Rvs167 have redundant roles in actomyosin ring function during cytokinesis in budding yeast. PLoS ONE. 2013;8:e57846 pubmed publisher
    The Hof1 protein (Homologue of Fifteen) regulates formation of the primary septum during cytokinesis in the budding yeast Saccharomyces cerevisiae, whereas the orthologous Cdc15 protein in fission yeast regulates the actomyosin ring by ..

More Information

Publications62

  1. Poirier C, Ng W, Robinson D, Iglesias P. Deconvolution of the cellular force-generating subsystems that govern cytokinesis furrow ingression. PLoS Comput Biol. 2012;8:e1002467 pubmed publisher
    b>Cytokinesis occurs through the coordinated action of several biochemically-mediated stresses acting on the cytoskeleton...
  2. Mathieu J, Cauvin C, Moch C, Radford S, Sampaio P, Perdigoto C, et al. Aurora B and cyclin B have opposite effects on the timing of cytokinesis abscission in Drosophila germ cells and in vertebrate somatic cells. Dev Cell. 2013;26:250-65 pubmed publisher
    Abscission is the last step of cytokinesis that physically separates the cytoplasm of sister cells. As the final stage of cell division, abscission is poorly characterized during animal development...
  3. Kotelevets N, Fabbro D, Huwiler A, Zangemeister Wittke U. Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesis. PLoS ONE. 2012;7:e39209 pubmed publisher
    ..unveiled decreased cdc2 activity and expression of Chk1, which may compromise spindle checkpoint function and cytokinesis. Indeed, SK-1 kd cells entered mitosis but failed to divide, and in the presence of taxol also failed to ..
  4. Sharifmoghadam M, Curto M, Hoya M, de Leon N, Martín García R, Doncel C, et al. The integrity of the cytokinesis machinery under stress conditions requires the glucan synthase Bgs1p and its regulator Cfh3p. PLoS ONE. 2012;7:e42726 pubmed publisher
    In yeast, cytokinesis requires coordination between nuclear division, acto-myosin ring contraction, and septum synthesis...
  5. Speit G, Linsenmeyer R, Schütz P, Kuehner S. Insensitivity of the in vitro cytokinesis-block micronucleus assay with human lymphocytes for the detection of DNA damage present at the start of the cell culture. Mutagenesis. 2012;27:743-7 pubmed publisher
    The cytokinesis-block micronucleus assay (CBMN assay) with cultured human lymphocytes is a well-established assay in genotoxicity testing and human biomonitoring...
  6. De Storme N, Copenhaver G, Geelen D. Production of diploid male gametes in Arabidopsis by cold-induced destabilization of postmeiotic radial microtubule arrays. Plant Physiol. 2012;160:1808-26 pubmed publisher
    ..the formation of radial microtubule arrays at telophase II and consequently leads to defects in postmeiotic cytokinesis and cell wall formation...
  7. Herszterg S, Leibfried A, Bosveld F, Martin C, Bellaiche Y. Interplay between the dividing cell and its neighbors regulates adherens junction formation during cytokinesis in epithelial tissue. Dev Cell. 2013;24:256-70 pubmed publisher
    ..Here, we found that AJ formation is coordinated with cytokinesis and relies on an interplay between the dividing cell and its neighbors...
  8. Brown H, Knowlton A, Grieshaber S. Chlamydial infection induces host cytokinesis failure at abscission. Cell Microbiol. 2012;14:1554-67 pubmed publisher
    ..Two mechanisms that are known to initiate multinucleation are cell fusion and cytokinesis failure...
  9. Hu C, Ozlu N, Coughlin M, Steen J, Mitchison T. Plk1 negatively regulates PRC1 to prevent premature midzone formation before cytokinesis. Mol Biol Cell. 2012;23:2702-11 pubmed publisher
    To achieve mitosis and cytokinesis, microtubules must assemble into distinct structures at different stages of cell division-mitotic spindles to segregate the chromosomes before anaphase and midzones to keep sister genomes apart and ..
  10. Huang X, Ding L, Pan R, Ma P, Cheng P, Zhang C, et al. WHAMM is required for meiotic spindle migration and asymmetric cytokinesis in mouse oocytes. Histochem Cell Biol. 2013;139:525-34 pubmed publisher
    ..si)RNA into the oocyte cytoplasm resulted in failure of spindle migration, disruption of asymmetric cytokinesis and a decrease in the first polar body extrusion rate during meiotic maturation...
  11. Giansanti M, Fuller M. What Drosophila spermatocytes tell us about the mechanisms underlying cytokinesis. Cytoskeleton (Hoboken). 2012;69:869-81 pubmed publisher
    b>Cytokinesis separates the genomic material and organelles of a dividing cell equitably into two physically distinct daughter cells at the end of cell division...
  12. Debruhl H, Wen H, Lipsick J. The complex containing Drosophila Myb and RB/E2F2 regulates cytokinesis in a histone H2Av-dependent manner. Mol Cell Biol. 2013;33:1809-18 pubmed publisher
    ..We now show that binucleate cells, the hallmark phenotype of cytokinesis failure, accumulate in Myb-null ovarian follicle cell and wing disc epithelia...
  13. Cortés J, Sato M, Munoz J, Moreno M, Clemente Ramos J, Ramos M, et al. Fission yeast Ags1 confers the essential septum strength needed for safe gradual cell abscission. J Cell Biol. 2012;198:637-56 pubmed publisher
    Fungal cytokinesis requires the assembly of a dividing septum wall. In yeast, the septum has to be selectively digested during the critical cell separation process...
  14. Estey M, Di Ciano Oliveira C, Froese C, Fung K, Steels J, Litchfield D, et al. Mitotic regulation of SEPT9 protein by cyclin-dependent kinase 1 (Cdk1) and Pin1 protein is important for the completion of cytokinesis. J Biol Chem. 2013;288:30075-86 pubmed publisher
    ..Expression of mutant SEPT9 that is defective in Pin1 binding was unable to rescue cytokinesis defects caused by SEPT9 depletion but rather induced dominant-negative defects in cytokinesis...
  15. Proctor S, Minc N, Boudaoud A, Chang F. Contributions of turgor pressure, the contractile ring, and septum assembly to forces in cytokinesis in fission yeast. Curr Biol. 2012;22:1601-8 pubmed publisher
    A paradigm of cytokinesis in animal cells is that the actomyosin contractile ring provides the primary force to divide the cell...
  16. Lv L, Zhang T, Yi Q, Huang Y, Wang Z, Hou H, et al. Tetraploid cells from cytokinesis failure induce aneuploidy and spontaneous transformation of mouse ovarian surface epithelial cells. Cell Cycle. 2012;11:2864-75 pubmed publisher
    ..by fluorescence in situ hybridization (FISH), we demonstrated that tetraploid cells originally arose from cytokinesis failure of bipolar mitosis in diploid cells, and gave rise to aneuploid cells through chromosome mis-..
  17. Park M, Touihri S, Müller I, Mayer U, Jurgens G. Sec1/Munc18 protein stabilizes fusion-competent syntaxin for membrane fusion in Arabidopsis cytokinesis. Dev Cell. 2012;22:989-1000 pubmed publisher
    ..We investigated syntaxin-SM protein interaction in membrane fusion of Arabidopsis cytokinesis, which involves cytokinesis-specific syntaxin KNOLLE and SM protein KEULE...
  18. Lekomtsev S, Su K, Pye V, Blight K, Sundaramoorthy S, Takaki T, et al. Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis. Nature. 2012;492:276-9 pubmed publisher
    At the end of cell division, cytokinesis splits the cytoplasm of nascent daughter cells and partitions segregated sister genomes...
  19. McHugh M, Lopez M, Ho C, Spitz M, Etzel C, El Zein R. Use of the cytokinesis-blocked micronucleus assay to detect gender differences and genetic instability in a lung cancer case-control study. Cancer Epidemiol Biomarkers Prev. 2013;22:135-45 pubmed publisher
    ..g., exhaust) and smoking among 500 lung cancer cases and 500 controls using the cytokinesis-blocked micronucleus (CBMN) assay...
  20. Hyodo T, Ito S, Hasegawa H, Asano E, Maeda M, Urano T, et al. Misshapen-like kinase 1 (MINK1) is a novel component of striatin-interacting phosphatase and kinase (STRIPAK) and is required for the completion of cytokinesis. J Biol Chem. 2012;287:25019-29 pubmed publisher
    b>Cytokinesis is initiated by constriction of the cleavage furrow and terminated by abscission of the intercellular bridge that connects two separating daughter cells...
  21. Balasubramanian M, Srinivasan R, Huang Y, Ng K. Comparing contractile apparatus-driven cytokinesis mechanisms across kingdoms. Cytoskeleton (Hoboken). 2012;69:942-56 pubmed publisher
    b>Cytokinesis is the final stage of the cell cycle during which a cell physically divides into two daughters through the assembly of new membranes (and cell wall in some cases) between the forming daughters...
  22. Takeda T, Robinson I, Savoian M, Griffiths J, Whetton A, McMahon H, et al. Drosophila F-BAR protein Syndapin contributes to coupling the plasma membrane and contractile ring in cytokinesis. Open Biol. 2013;3:130081 pubmed publisher
    b>Cytokinesis is a highly ordered cellular process driven by interactions between central spindle microtubules and the actomyosin contractile ring linked to the dynamic remodelling of the plasma membrane...
  23. Crowell E, Tinevez J, Echard A. A simple model for the fate of the cytokinesis midbody remnant: implications for remnant degradation by autophagy. Bioessays. 2013;35:472-81 pubmed publisher
    When a cell divides, it produces two daughter cells initially connected by a cytokinesis bridge, which is eventually cut through abscission...
  24. Wei Y, Hu H, Lun Z, Li Z. The cooperative roles of two kinetoplastid-specific kinesins in cytokinesis and in maintaining cell morphology in bloodstream trypanosomes. PLoS ONE. 2013;8:e73869 pubmed publisher
    ..RNAi of TbKIN-C or TbKIN-D in the bloodstream form inhibits cell proliferation and leads to cell death, due to cytokinesis defects...
  25. Eikenes A, Brech A, Stenmark H, Haglund K. Spatiotemporal control of Cindr at ring canals during incomplete cytokinesis in the Drosophila male germline. Dev Biol. 2013;377:9-20 pubmed publisher
    ..and female gametogenesis in species ranging from insects to mammals, germ cell cyst formation by incomplete cytokinesis involves the stabilization of cleavage furrows and the formation of stable intercellular bridges called ring ..
  26. Founounou N, Loyer N, Le Borgne R. Septins regulate the contractility of the actomyosin ring to enable adherens junction remodeling during cytokinesis of epithelial cells. Dev Cell. 2013;24:242-55 pubmed publisher
    How adhesive contacts with neighbors may affect epithelial cell cytokinesis is unknown. We report that in Drosophila, septins are specifically required for planar (but not orthogonal) cytokinesis...
  27. Yang G, Mercado Uribe I, Multani A, Sen S, Shih I, Wong K, et al. RAS promotes tumorigenesis through genomic instability induced by imbalanced expression of Aurora-A and BRCA2 in midbody during cytokinesis. Int J Cancer. 2013;133:275-85 pubmed publisher
    ..BRCA2 inversely controlled RAS-associated genomic instability and ovarian tumorigenesis through regulation of cytokinesis and polyploidization...
  28. Ferreira J, Pereira A, Akhmanova A, Maiato H. Aurora B spatially regulates EB3 phosphorylation to coordinate daughter cell adhesion with cytokinesis. J Cell Biol. 2013;201:709-24 pubmed publisher
    ..remodeling mechanisms that prevent detachment from epithelia, while ensuring the successful completion of cytokinesis. Here we show that the microtubule end-binding (EB) proteins EB1 and EB3 play temporally distinct roles ..
  29. Pittman K, Skop A. Anterior PAR proteins function during cytokinesis and maintain DYN-1 at the cleavage furrow in Caenorhabditis elegans. Cytoskeleton (Hoboken). 2012;69:826-39 pubmed publisher
    ..Our data suggest a unique role for PAR proteins in cytokinesis. We have found that at the onset of cytokinesis, anterior PAR-6 and posterior PAR-2 proteins are redistributed ..
  30. Laporte D, Ojkic N, Vavylonis D, Wu J. ?-Actinin and fimbrin cooperate with myosin II to organize actomyosin bundles during contractile-ring assembly. Mol Biol Cell. 2012;23:3094-110 pubmed publisher
    ..assembles through the condensation of a broad band of nodes that forms at the cell equator in fission yeast cytokinesis. The condensation process depends on actin filaments that interconnect nodes...
  31. Guzman Vendrell M, Baldissard S, Almonacid M, Mayeux A, Paoletti A, Moseley J. Blt1 and Mid1 provide overlapping membrane anchors to position the division plane in fission yeast. Mol Cell Biol. 2013;33:418-28 pubmed publisher
    Spatial control of cytokinesis is essential for proper cell division. The molecular mechanisms that anchor the dynamic assembly and constriction of the cytokinetic ring at the plasma membrane remain unclear...
  32. White E, Glotzer M. Centralspindlin: at the heart of cytokinesis. Cytoskeleton (Hoboken). 2012;69:882-92 pubmed publisher
    The final step in the cell cycle is the formation of two genetically identical daughter cells by cytokinesis. At the heart of cytokinesis in animal cells is the centralspindlin complex which is composed of two proteins, a kinesin-like ..
  33. Deschamps C, Echard A, Niedergang F. Phagocytosis and cytokinesis: do cells use common tools to cut and to eat? Highlights on common themes and differences. Traffic. 2013;14:355-64 pubmed publisher
    ..compartments are required both for successful phagocytosis, the internalization of particulate material and for cytokinesis, the last step of cell division...
  34. San Martin J, de Jesus Andrade C, Mastroberti A, de Araujo Mariath J, Vanzela A. Asymmetric cytokinesis guide the development of pseudomonads in Rhynchospora pubera (Cyperaceae). Cell Biol Int. 2013;37:203-12 pubmed publisher
    ..The results are significant because they associate cellular polarisation and asymmetry with different cytoplasmic domains, and hence open new possibilities for studying cellular compartmentalisation and PCD...
  35. Qi X, Zheng H. Rab-A1c GTPase defines a population of the trans-Golgi network that is sensitive to endosidin1 during cytokinesis in Arabidopsis. Mol Plant. 2013;6:847-59 pubmed publisher
    ..from the trans-Golgi network (TGN) to the plasma membrane/cell wall and to the newly formed cell plate in cytokinesis. But how different Rab-A proteins may work in the TGN is not well studied...
  36. Schiel J, Simon G, Zaharris C, Weisz J, Castle D, Wu C, et al. FIP3-endosome-dependent formation of the secondary ingression mediates ESCRT-III recruitment during cytokinesis. Nat Cell Biol. 2012;14:1068-78 pubmed publisher
    The final cytokinesis event involves severing of the connecting intercellular bridge (ICB) between daughter cells...
  37. Watanabe S, De Zan T, Ishizaki T, Narumiya S. Citron kinase mediates transition from constriction to abscission through its coiled-coil domain. J Cell Sci. 2013;126:1773-84 pubmed publisher
    b>Cytokinesis is initiated by constriction of the cleavage furrow, and completed with separation of the two daughter cells by abscission. Control of transition from constriction to abscission is therefore crucial for cytokinesis...
  38. Green R, Paluch E, Oegema K. Cytokinesis in animal cells. Annu Rev Cell Dev Biol. 2012;28:29-58 pubmed publisher
    b>Cytokinesis, the final step in cell division, partitions the contents of a single cell into two. In animal cells, cytokinesis occurs through cortical remodeling orchestrated by the anaphase spindle...
  39. Cundell M, Bastos R, Zhang T, Holder J, Gruneberg U, Novak B, et al. The BEG (PP2A-B55/ENSA/Greatwall) pathway ensures cytokinesis follows chromosome separation. Mol Cell. 2013;52:393-405 pubmed publisher
    b>Cytokinesis follows separase activation and chromosome segregation...
  40. Zanin E, Desai A, Poser I, Toyoda Y, Andree C, Moebius C, et al. A conserved RhoGAP limits M phase contractility and coordinates with microtubule asters to confine RhoA during cytokinesis. Dev Cell. 2013;26:496-510 pubmed publisher
    During animal cell cytokinesis, the spindle directs contractile ring assembly by activating RhoA in a narrow equatorial zone...
  41. Watanabe S, De Zan T, Ishizaki T, Yasuda S, Kamijo H, Yamada D, et al. Loss of a Rho-regulated actin nucleator, mDia2, impairs cytokinesis during mouse fetal erythropoiesis. Cell Rep. 2013;5:926-32 pubmed publisher
    The small GTPase Rho and mDia2, a Rho-regulated actin nucleator, function as critical regulators of cytokinesis in cultured cells. However, their involvement in cytokinesis during mammalian development remains unknown...
  42. Mohan K, Iglesias P, Robinson D. Separation anxiety: stress, tension and cytokinesis. Exp Cell Res. 2012;318:1428-34 pubmed publisher
    b>Cytokinesis, the physical separation of a mother cell into two daughter cells, progresses through a series of well-defined changes in morphology. These changes involve distinct biochemical and mechanical processes...
  43. Moulding D, Moeendarbary E, Valon L, Record J, Charras G, Thrasher A. Excess F-actin mechanically impedes mitosis leading to cytokinesis failure in X-linked neutropenia by exceeding Aurora B kinase error correction capacity. Blood. 2012;120:3803-11 pubmed publisher
    ..overload of the aurora signaling pathway as subcritical inhibition of Aurora in CA-WASp cells caused increased cytokinesis failure, while overexpression reduced defects...
  44. Mendes Pinto I, Rubinstein B, Kucharavy A, Unruh J, Li R. Actin depolymerization drives actomyosin ring contraction during budding yeast cytokinesis. Dev Cell. 2012;22:1247-60 pubmed publisher
    ..filaments and myosin II are evolutionarily conserved force-generating components of the contractile ring during cytokinesis. Here we show that in budding yeast, actin filament depolymerization plays a major role in actomyosin ring ..
  45. Makyio H, Ohgi M, Takei T, Takahashi S, Takatsu H, Katoh Y, et al. Structural basis for Arf6-MKLP1 complex formation on the Flemming body responsible for cytokinesis. EMBO J. 2012;31:2590-603 pubmed publisher
    A small GTPase, Arf6, is involved in cytokinesis by localizing to the Flemming body (the midbody). However, it remains unknown how Arf6 contributes to cytokinesis...
  46. Hayashi M, Karlseder J. DNA damage associated with mitosis and cytokinesis failure. Oncogene. 2013;32:4593-601 pubmed publisher
    ..Here, we analyze several distinct malfunctions during mitosis and cytokinesis that lead to de novo DNA damage generation.
  47. Hasegawa H, Hyodo T, Asano E, Ito S, Maeda M, Kuribayashi H, et al. The role of PLK1-phosphorylated SVIL in myosin II activation and cytokinetic furrowing. J Cell Sci. 2013;126:3627-37 pubmed publisher
    ..Our study indicates a possible role of phosphorylated SVIL as a molecular link between the central spindle and the contractile ring to coordinate the activation of myosin II for the ingression of the cleavage furrow. ..
  48. Saha S, Pollard T. Anillin-related protein Mid1p coordinates the assembly of the cytokinetic contractile ring in fission yeast. Mol Biol Cell. 2012;23:3982-92 pubmed publisher
    ..We conclude that orderly assembly of the contractile ring in wild-type cells depends on Mid1p to recruit myosin-II, Rng2p, and Cdc15p to nodes and to place cytokinetic nodes around the cell equator. ..
  49. Lee I, Coffman V, Wu J. Contractile-ring assembly in fission yeast cytokinesis: Recent advances and new perspectives. Cytoskeleton (Hoboken). 2012;69:751-63 pubmed publisher
    The fission yeast Schizosaccharomyces pombe is an excellent model organism to study cytokinesis. Here, we review recent advances on contractile-ring assembly in fission yeast...
  50. Pollard L, Onishi M, Pringle J, Lord M. Fission yeast Cyk3p is a transglutaminase-like protein that participates in cytokinesis and cell morphogenesis. Mol Biol Cell. 2012;23:2433-44 pubmed publisher
    ..The phenotype of a cyk3 knockout strain indicates a primary role for Cyk3p in cytokinesis. Correspondingly, Cyk3p localizes both to the actomyosin contractile ring and the division septum, promoting ..
  51. Smith T, Fridy P, Li Y, Basil S, Arjun S, Friesen R, et al. Supervillin binding to myosin II and synergism with anillin are required for cytokinesis. Mol Biol Cell. 2013;24:3603-19 pubmed publisher
    b>Cytokinesis, the process by which cytoplasm is apportioned between dividing daughter cells, requires coordination of myosin II function, membrane trafficking, and central spindle organization...
  52. Pampalona J, Frias C, Genesca A, Tusell L. Progressive telomere dysfunction causes cytokinesis failure and leads to the accumulation of polyploid cells. PLoS Genet. 2012;8:e1002679 pubmed publisher
    ..Live-cell imaging revealed that these polyploid cells emerged after abortive cytokinesis due to the persistence of anaphase bridges with large intervening chromatin in the cleavage plane...
  53. Echard A. Phosphoinositides and cytokinesis: the "PIP" of the iceberg. Cytoskeleton (Hoboken). 2012;69:893-912 pubmed publisher
    ..Increasing evidence indicates that several phosphoinositides, particularly PtdIns(4,5)P(2) , are essential for cytokinesis, notably after furrow ingression...