cell division


Summary: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.

Top Publications

  1. Pietra S, Gustavsson A, Kiefer C, Kalmbach L, Hörstedt P, Ikeda Y, et al. Arabidopsis  SABRE and CLASP interact to stabilize cell division plane orientation and planar polarity. Nat Commun. 2013;4:2779 pubmed publisher
    The orientation of cell division and the coordination of cell polarity within the plane of the tissue layer (planar polarity) contribute to shape diverse multicellular organisms...
  2. Ahmad S, Busser B, Huang D, Cozart E, Michaud S, Zhu X, et al. Machine learning classification of cell-specific cardiac enhancers uncovers developmental subnetworks regulating progenitor cell division and cell fate specification. Development. 2014;141:878-88 pubmed publisher
  3. Grob A, Colleran C, McStay B. Construction of synthetic nucleoli in human cells reveals how a major functional nuclear domain is formed and propagated through cell division. Genes Dev. 2014;28:220-30 pubmed publisher
    ..For the first time, we establish the sequence requirements for nucleolar biogenesis and provide proof that this is a staged process where UBF-dependent mitotic bookmarking precedes function-dependent nucleolar assembly. ..
  4. Zigman M, Laumann Lipp N, Titus T, Postlethwait J, Moens C. Hoxb1b controls oriented cell division, cell shape and microtubule dynamics in neural tube morphogenesis. Development. 2014;141:639-49 pubmed publisher
    ..gene, which shares ancestral functions with mammalian Hoxa1, in controlling progenitor cell shape and oriented cell division during zebrafish anterior hindbrain neural tube morphogenesis...
  5. Sun B, Looi L, Guo S, He Z, Gan E, Huang J, et al. Timing mechanism dependent on cell division is invoked by Polycomb eviction in plant stem cells. Science. 2014;343:1248559 pubmed publisher
    ..AG binding to the KNU promoter causes the eviction of the Polycomb group proteins from the locus, leading to cell division-dependent induction...
  6. Loose M, Mitchison T. The bacterial cell division proteins FtsA and FtsZ self-organize into dynamic cytoskeletal patterns. Nat Cell Biol. 2014;16:38-46 pubmed publisher
    ..Our findings provide a model for the initial steps of bacterial cell division and illustrate how dynamic polymers can self-organize into large-scale structures.
  7. Francia M, Striepen B. Cell division in apicomplexan parasites. Nat Rev Microbiol. 2014;12:125-36 pubmed publisher
    ..undergo a complex developmental process in the cells of their hosts, which includes genome replication, cell division and the assembly of new invasive stages...
  8. Pimentel B, Nair R, Bermejo Rodríguez C, Preston M, Agu C, Wang X, et al. Toxin Kid uncouples DNA replication and cell division to enforce retention of plasmid R1 in Escherichia coli cells. Proc Natl Acad Sci U S A. 2014;111:2734-9 pubmed publisher
    ..plasmid, and we show that this provokes highly selective restriction of protein outputs that inhibits cell division temporarily, avoiding plasmid loss, and stimulates DNA replication, promoting plasmid rescue...
  9. Silverman Gavrila R, Silverman Gavrila L, Bendeck M. Cell division fidelity is altered during the vascular response to injury: its novel role in atherosclerosis progression. Am J Pathol. 2013;182:628-39 pubmed publisher
    ..However, little is known about division fidelity in vascular disorders. We have analyzed the cell division fidelity during the rapid SMC proliferation that occurs after balloon injury of the rat carotid artery using ..

More Information


  1. Cao S, Wang J, Chen D. Settlement and cell division of diatom Navicula can be influenced by light of various qualities and intensities. J Basic Microbiol. 2013;53:884-94 pubmed publisher
    Diatom settlement and cell division is important in two major aspects. Firstly, biofouling is a costly problem in the shipping industry that necessitates the effective inhibition of diatom settlement and proliferation...
  2. Militello R, Munafo D, Berón W, Lopez L, Monier S, Goud B, et al. Rab24 is required for normal cell division. Traffic. 2013;14:502-18 pubmed publisher
    ..In this study, we have analyzed the distribution of Rab24 throughout cell division. We have observed that Rab24 was located at the mitotic spindle in metaphase, at the midbody during telophase ..
  3. Specht M, Dempwolff F, Sch tzle S, Thomann R, Waidner B. Localization of FtsZ in Helicobacter pylori and consequences for cell division. J Bacteriol. 2013;195:1411-20 pubmed publisher
    Of the various kinds of cell division, the most common mode is binary fission, the division of a cell into two morphologically identical daughter cells...
  4. Liu Y, Wang P, Wang Y, Zhu Z, Lao F, Liu X, et al. The influence on cell cycle and cell division by various cadmium-containing quantum dots. Small. 2013;9:2440-51 pubmed publisher
    ..are important for understanding the intracellular effects of QDs on the mitotic spindle and chromosomes during cell division. Furthermore, this kind of cytotoxicity evaluation method should be applicable to studies of the biological ..
  5. Persson H, Købler C, Mølhave K, Samuelson L, Tegenfeldt J, Oredsson S, et al. Fibroblasts cultured on nanowires exhibit low motility, impaired cell division, and DNA damage. Small. 2013;9:4006-16, 3905 pubmed publisher
    ..Fibroblasts cultured on long nanowires exhibit failed cell division, DNA damage, increased ROS content and respiration...
  6. Sass P, Brötz Oesterhelt H. Bacterial cell division as a target for new antibiotics. Curr Opin Microbiol. 2013;16:522-30 pubmed publisher
    ..In recent years, the inhibition of the bacterial divisome, mainly by targeting the central cell division mediator FtsZ, has been recognized as a promising strategy for antibiotic attack...
  7. Hormoz S. Stem cell population asymmetry can reduce rate of replicative aging. J Theor Biol. 2013;331:19-27 pubmed publisher
    ..Our results highlight the importance of a population-level understanding of stem cells, and may explain the prevalence of population asymmetry in a wide variety of cycling tissues. ..
  8. Roeder A, Cunha A, Ohno C, Meyerowitz E. Cell cycle regulates cell type in the Arabidopsis sepal. Development. 2012;139:4416-27 pubmed publisher
    The formation of cellular patterns during development requires the coordination of cell division with cell identity specification...
  9. Vollmer J, Schiefer A, Schneider T, Jülicher K, Johnston K, Taylor M, et al. Requirement of lipid II biosynthesis for cell division in cell wall-less Wolbachia, endobacteria of arthropods and filarial nematodes. Int J Med Microbiol. 2013;303:140-9 pubmed publisher
    ..of Wolbachia peptidoglycan-associated lipoprotein, demonstrating that lipid II is required for coordinated cell division and may interact with the lipoprotein...
  10. Reyes Lamothe R, Tran T, Meas D, Lee L, Li A, Sherratt D, et al. High-copy bacterial plasmids diffuse in the nucleoid-free space, replicate stochastically and are randomly partitioned at cell division. Nucleic Acids Res. 2014;42:1042-51 pubmed publisher
    ..inheritance of plasmids depends on their autonomous replication and efficient partition to daughter cells at cell division. Active partition systems have not been identified for high-copy number plasmids, and it has been generally ..
  11. Jubault M, Lariagon C, Taconnat L, Renou J, Gravot A, Delourme R, et al. Partial resistance to clubroot in Arabidopsis is based on changes in the host primary metabolism and targeted cell division and expansion capacity. Funct Integr Genomics. 2013;13:191-205 pubmed publisher
  12. Cerruti B, Puliafito A, Shewan A, Yu W, Combes A, Little M, et al. Polarity, cell division, and out-of-equilibrium dynamics control the growth of epithelial structures. J Cell Biol. 2013;203:359-72 pubmed publisher
    ..structure is governed by mechanical constraints, cellular apico-basal polarity, and spatially controlled cell division. Here we compared the predictions of a mathematical model of epithelial growth with the morphological analysis ..
  13. van der Ploeg R, Verheul J, Vischer N, Alexeeva S, Hoogendoorn E, Postma M, et al. Colocalization and interaction between elongasome and divisome during a preparative cell division phase in Escherichia coli. Mol Microbiol. 2013;87:1074-87 pubmed publisher
    ..by insertion of peptidoglycan into the lateral wall during cell elongation and synthesis of new poles during cell division. The monofunctional transpeptidases PBP2 and PBP3 are part of specialized protein complexes called elongasome ..
  14. Bush M, Bibb M, Chandra G, Findlay K, Buttner M. Genes required for aerial growth, cell division, and chromosome segregation are targets of WhiA before sporulation in Streptomyces venezuelae. MBio. 2013;4:e00684-13 pubmed publisher
    ..venezuelae, and several genes encoding key proteins of the Streptomyces cell division machinery, such as ftsZ, ftsW, and ftsK, were found to be directly activated by WhiA during development...
  15. Heyman J, Cools T, Vandenbussche F, Heyndrickx K, Van Leene J, Vercauteren I, et al. ERF115 controls root quiescent center cell division and stem cell replenishment. Science. 2013;342:860-3 pubmed publisher
    ..Here, we identified the ERF115 transcription factor as a rate-limiting factor of QC cell division, acting as a transcriptional activator of the phytosulfokine PSK5 peptide hormone...
  16. Ruggiero A, De Simone P, Smaldone G, Squeglia F, Berisio R. Bacterial cell division regulation by Ser/Thr kinases: a structural perspective. Curr Protein Pept Sci. 2012;13:756-66 pubmed
    ..Numerous studies have revealed how phosphorylation/dephosphorylation of Ser/Thr protein-kinases governs cell division and cell wall biosynthesis and that Ser/Thr protein kinases are responsible for distinct phenotypes, dependent ..
  17. Roubinet C, Tran P, Piel M. Common mechanisms regulating cell cortex properties during cell division and cell migration. Cytoskeleton (Hoboken). 2012;69:957-72 pubmed publisher
    ..and White [1988; Science 239:883-889], we draw a parallel between the regulation of the cell cortex during cell division and cell migration in animal cells...
  18. Etchells J, Provost C, Turner S. Plant vascular cell division is maintained by an interaction between PXY and ethylene signalling. PLoS Genet. 2012;8:e1002997 pubmed publisher
    ..These transcription factors are required for normal cell division in the cambium and procambium...
  19. Holmes N, Walshaw J, Leggett R, Thibessard A, Dalton K, Gillespie M, et al. Coiled-coil protein Scy is a key component of a multiprotein assembly controlling polarized growth in Streptomyces. Proc Natl Acad Sci U S A. 2013;110:E397-406 pubmed publisher
  20. Francia M, Jordan C, Patel J, Sheiner L, Demerly J, Fellows J, et al. Cell division in Apicomplexan parasites is organized by a homolog of the striated rootlet fiber of algal flagella. PLoS Biol. 2012;10:e1001444 pubmed publisher
    ..that in the algal ancestor served as the rootlet of the flagellar basal bodies is required for parasite cell division. Parasite striated fiber assemblins (SFA) polymerize into a dynamic fiber that emerges from the centrosomes ..
  21. Fenton A, Gerdes K. Direct interaction of FtsZ and MreB is required for septum synthesis and cell division in Escherichia coli. EMBO J. 2013;32:1953-65 pubmed publisher
    ..Bacterial cell elongation is controlled by actin-MreB while cell division is governed by tubulin-FtsZ...
  22. Gao X, McDonald J, Hlatky L, Enderling H. Acute and fractionated irradiation differentially modulate glioma stem cell division kinetics. Cancer Res. 2013;73:1481-90 pubmed publisher
    ..We hypothesize a constitutive activation of stem cell division kinetics signaling pathways during fractionated treatment, which contributes to the frequently observed ..
  23. Buckley C, Ren X, Ward L, Girdler G, Araya C, Green M, et al. Mirror-symmetric microtubule assembly and cell interactions drive lumen formation in the zebrafish neural rod. EMBO J. 2013;32:30-44 pubmed publisher
    ..This occurs in advance and is independent of the midline cell division that has been shown to have a powerful role in lumen organisation...
  24. Egan A, Vollmer W. The physiology of bacterial cell division. Ann N Y Acad Sci. 2013;1277:8-28 pubmed publisher
    Bacterial cell division is facilitated by the divisome, a dynamic multiprotein assembly localizing at mid-cell to synthesize the stress-bearing peptidoglycan and to constrict all cell envelope layers...
  25. Pazos M, Natale P, Vicente M. A specific role for the ZipA protein in cell division: stabilization of the FtsZ protein. J Biol Chem. 2013;288:3219-26 pubmed publisher
    In Escherichia coli, the cell division protein FtsZ is anchored to the cytoplasmic membrane by the action of the bitopic membrane protein ZipA and the cytoplasmic protein FtsA...
  26. Lemaitre F, Moreau H, Vedele L, Bousso P. Phenotypic CD8+ T cell diversification occurs before, during, and after the first T cell division. J Immunol. 2013;191:1578-85 pubmed publisher
    ..is programmed before clonal expansion or in later phases as a result of stochastic events or asymmetric cell division is not fully understood...
  27. Patzelt D, Wang H, Buchholz I, Rohde M, Gröbe L, Pradella S, et al. You are what you talk: quorum sensing induces individual morphologies and cell division modes in Dinoroseobacter shibae. ISME J. 2013;7:2274-86 pubmed publisher
    ..Transcriptome analysis revealed that expression of genes responsible for control of cell division was reduced in this strain, providing the link between QS and the observed phenotype...
  28. Lee K, Tsutsui T, Honda K, Asano R, Kumagai I, Ohtake H, et al. Generation of high-producing cell lines by overexpression of cell division cycle 25 homolog A in Chinese hamster ovary cells. J Biosci Bioeng. 2013;116:754-60 pubmed publisher
    ..The full-length cDNA of CHO cell division cycle 25 homolog A (Cdc25A) was introduced into CHO DG44 cells and the effects of CDC25A overexpression on the ..
  29. Zupan J, Cameron T, Anderson Furgeson J, Zambryski P. Dynamic FtsA and FtsZ localization and outer membrane alterations during polar growth and cell division in Agrobacterium tumefaciens. Proc Natl Acad Sci U S A. 2013;110:9060-5 pubmed publisher
    Growth and cell division in rod-shaped bacteria have been primarily studied in species that grow predominantly by peptidoglycan (PG) synthesis along the length of the cell...
  30. Nelissen H, Rymen B, Coppens F, Dhondt S, Fiorani F, Beemster G. Kinematic analysis of cell division in leaves of mono- and dicotyledonous species: a basis for understanding growth and developing refined molecular sampling strategies. Methods Mol Biol. 2013;959:247-64 pubmed publisher
    The cellular level processes cell division and cell expansion form a crucial level linking regulatory processes at the molecular level to whole plant growth rates and organ size and shape...
  31. Takahashi H, Iwakawa H, Ishibashi N, Kojima S, Matsumura Y, Prananingrum P, et al. Meta-analyses of microarrays of Arabidopsis asymmetric leaves1 (as1), as2 and their modifying mutants reveal a critical role for the ETT pathway in stabilization of adaxial-abaxial patterning and cell division during leaf development. Plant Cell Physiol. 2013;54:418-31 pubmed publisher
    ..ARF3/ETT and ARF4 functions, which suggests that the AS1-AS2-ETT pathway plays a critical role in controlling the cell division cycle and the biosynthesis of cytokinin around SAM to stabilize leaf development in Arabidopsis thaliana.
  32. Ballabeni A, Zamponi R, Moore J, Helin K, Kirschner M. Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication. Proc Natl Acad Sci U S A. 2013;110:E2848-53 pubmed publisher
    ..Therefore, Geminin is a master regulator of cell-cycle progression that ensures the timely onset of DNA replication and prevents its rereplication. ..
  33. Ambrose C, Ruan Y, Gardiner J, Tamblyn L, Catching A, Kirik V, et al. CLASP interacts with sorting nexin 1 to link microtubules and auxin transport via PIN2 recycling in Arabidopsis thaliana. Dev Cell. 2013;24:649-59 pubmed publisher
    Polarized movement of auxin generates concentration gradients within plant tissues to control cell division patterns and growth direction by modulating microtubule organization...
  34. Buczacki S, Zecchini H, Nicholson A, Russell R, Vermeulen L, Kemp R, et al. Intestinal label-retaining cells are secretory precursors expressing Lgr5. Nature. 2013;495:65-9 pubmed publisher
    ..These findings establish quiescent cells as an effective clonogenic reserve and provide a motivation for investigating their role in pathologies such as colorectal cancers and intestinal inflammation...
  35. Abyzov A, Iskow R, Gokcumen O, Radke D, Balasubramanian S, Pei B, et al. Analysis of variable retroduplications in human populations suggests coupling of retrotransposition to cell division. Genome Res. 2013;23:2042-52 pubmed publisher
    ..These findings suggest that cell division is coupled to retrotransposition and, perhaps, is even a requirement for it.
  36. Stewart C, Deery W, Egan E, Myles B, Petti A. The product of SPO1 gene 56 inhibits host cell division during infection of Bacillus subtilis by bacteriophage SPO1. Virology. 2013;447:249-53 pubmed publisher
    ..cells of Bacillus subtilis continue to grow after being infected by bacteriophage SPO1, they do not undergo cell division. The product of SPO1 gene 56 is necessary and sufficient for this inhibition of cell division...
  37. Siebring J, Elema M, Drubi Vega F, Kovács Á, Haccou P, Kuipers O. Repeated triggering of sporulation in Bacillus subtilis selects against a protein that affects the timing of cell division. ISME J. 2014;8:77-87 pubmed publisher
    ..enzyme TagE, UDP-glucose, has recently been shown to be an intracellular proxy for nutrient availability, and influences the timing of cell division. Here we suggest that UDP-glucose also influences timing of cellular differentiation.
  38. Yadlapalli S, Yamashita Y. Chromosome-specific nonrandom sister chromatid segregation during stem-cell division. Nature. 2013;498:251-4 pubmed publisher
    Adult stem cells undergo asymmetric cell division to self-renew and give rise to differentiated cells that comprise mature tissue...
  39. Hwang L, Vecchiarelli A, Han Y, Mizuuchi M, Harada Y, Funnell B, et al. ParA-mediated plasmid partition driven by protein pattern self-organization. EMBO J. 2013;32:1238-49 pubmed publisher
    DNA segregation ensures the stable inheritance of genetic material prior to cell division. Many bacterial chromosomes and low-copy plasmids, such as the plasmids P1 and F, employ a three-component system to partition replicated genomes: ..
  40. Chen Y, Kuo C, Wei M, Wu K, Su P, Huang C, et al. Intracellular viscoelasticity of HeLa cells during cell division studied by video particle-tracking microrheology. J Biomed Opt. 2014;19:011008 pubmed publisher
    b>Cell division plays an important role in regulating cell proliferation and differentiation...
  41. Trip E, Veening J, Stewart E, Errington J, Scheffers D. Balanced transcription of cell division genes in Bacillus subtilis as revealed by single cell analysis. Environ Microbiol. 2013;15:3196-209 pubmed publisher
    b>Cell division in bacteria is carried out by a set of conserved proteins that all have to function at the correct place and time...
  42. Homem C, Knoblich J. Drosophila neuroblasts: a model for stem cell biology. Development. 2012;139:4297-310 pubmed publisher
    ..system for neural stem cell biology and have provided key insights into the mechanisms underlying asymmetric cell division and tumor formation...
  43. Avraham N, Soifer I, Carmi M, Barkai N. Increasing population growth by asymmetric segregation of a limiting resource during cell division. Mol Syst Biol. 2013;9:656 pubmed publisher
    ..Notably, while deletion of WHI5 alleviates daughter cell division arrest in low-zinc conditions, it results in a lower final population size, as cell division rate becomes ..
  44. Tanimoto H, Sano M. Dynamics of traction stress field during cell division. Phys Rev Lett. 2012;109:248110 pubmed
    ..The asymmetry of the traction stress and the orientation of the division axis matched throughout the division process, suggesting the possible role of the mechanical force as a "store" of the orientational information...
  45. Zhou F, Rasmussen A, Lee S, Agaisse H. The UPD3 cytokine couples environmental challenge and intestinal stem cell division through modulation of JAK/STAT signaling in the stem cell microenvironment. Dev Biol. 2013;373:383-93 pubmed publisher
    ..therefore supports the notion that the production of the UPD3 cytokine in stem cell progeny (ECs and EBs) stimulates intestinal stem cell division through modulation of JAK/STAT signaling in the stem cell microenvironment (EBs and VMs).
  46. Cambridge J, Blinkova A, Magnan D, Bates D, Walker J. A replication-inhibited unsegregated nucleoid at mid-cell blocks Z-ring formation and cell division independently of SOS and the SlmA nucleoid occlusion protein in Escherichia coli. J Bacteriol. 2014;196:36-49 pubmed publisher
    Chromosome replication and cell division of Escherichia coli are coordinated with growth such that wild-type cells divide once and only once after each replication cycle...
  47. Rompolas P, Mesa K, Greco V. Spatial organization within a niche as a determinant of stem-cell fate. Nature. 2013;502:513-8 pubmed publisher
    ..This study provides a general model for niche-induced fate determination in adult tissues. ..
  48. Shih Y, Zheng M. Spatial control of the cell division site by the Min system in Escherichia coli. Environ Microbiol. 2013;15:3229-39 pubmed publisher
    The Min system of Escherichia coli is involved in mediating placement of the cell division site at the midcell; this is accomplished through partitioning of the cell division inhibitor MinC to the cell poles to block aberrant polar ..
  49. Rasmussen C, Wright A, Muller S. The role of the cytoskeleton and associated proteins in determination of the plant cell division plane. Plant J. 2013;75:258-69 pubmed publisher
    ..as in all eukaryotic organisms, microtubule- and actin-filament based structures play fundamental roles during cell division. In addition to the mitotic spindle, plant cells have evolved a unique cytoskeletal structure that designates ..
  50. Treuner Lange A, Aguiluz K, van der Does C, Gómez Santos N, Harms A, Schumacher D, et al. PomZ, a ParA-like protein, regulates Z-ring formation and cell division in Myxococcus xanthus. Mol Microbiol. 2013;87:235-53 pubmed publisher
    ..These data show that PomZ is important for Z-ring formation and is a spatial regulator of Z-ring formation and cell division. The cell cycle-dependent localization of PomZ at midcell provides a mechanism for coupling cell cycle ..
  51. Paridaen J, Wilsch Bräuninger M, Huttner W. Asymmetric inheritance of centrosome-associated primary cilium membrane directs ciliogenesis after cell division. Cell. 2013;155:333-44 pubmed publisher
    ..However, the fate of the ciliary membrane upon cell division is unknown...
  52. Okamoto S, Furuya K, Nozaki S, Aoki K, Niki H. Synchronous activation of cell division by light or temperature stimuli in the dimorphic yeast Schizosaccharomyces japonicus. Eukaryot Cell. 2013;12:1235-43 pubmed publisher
    ..Both light and temperature, which are daily external cues, have the same effect on growing hyphal cells. A dual sensing mechanism of external cues allows organisms to adapt to daily changes of environmental alteration. ..
  53. Patel K, Scrimieri F, Ghosh S, Zhong J, Kim M, Ren Y, et al. FAM190A deficiency creates a cell division defect. Am J Pathol. 2013;183:296-303 pubmed publisher
    ..FAM190A interacted with EXOC1 and Ndel1, which function in cytoskeletal organization and the cell division cycle. Levels of FAM190A protein peaked 12 hours after release from thymidine block, corresponding to M-phase...