fucose

Summary

Summary: A six-member ring deoxysugar with the chemical formula C6H12O5. It lacks a hydroxyl group on the carbon at position 6 of the molecule.

Top Publications

  1. Raju R, Ramraj A, Vincent M, Hillier I, Burton N. Carbohydrate-protein recognition probed by density functional theory and ab initio calculations including dispersive interactions. Phys Chem Chem Phys. 2008;10:6500-8 pubmed publisher
    Carbohydrate-protein recognition has been studied by electronic structure calculations of complexes of fucose and glucose with toluene, p-hydroxytoluene and 3-methylindole, the latter aromatic molecules being analogues of phenylalanine, ..
  2. Ju Y, Oh D. Characterization of a recombinant L-fucose isomerase from Caldicellulosiruptor saccharolyticus that isomerizes L-fucose, D-arabinose, D-altrose, and L-galactose. Biotechnol Lett. 2010;32:299-304 pubmed publisher
    A recombinant L-fucose isomerase from Caldicellulosiruptor saccharolyticus was purified as a single 68 kDa band with an activity of 76 U mg(-1). The molecular mass of the native enzyme was 204 kDa as a trimer...
  3. Takeuchi T, Sugiura K, Nishiyama K, Takahashi H, Natsugari H, Arata Y, et al. ?-galactosidases from jack bean and Streptococcus have different cleaving abilities towards fucose-containing sugars. Biol Pharm Bull. 2011;34:567-9 pubmed
    ..the sugar-cleaving abilities of ?-galactosidases from jack bean and Streptococcus towards sugars containing fucose residues, and found that jack bean ?-galactosidase has an ability to cleave the ?1-3 linkage between galactose (..
  4. Ale M, Maruyama H, Tamauchi H, Mikkelsen J, Meyer A. Fucose-containing sulfated polysaccharides from brown seaweeds inhibit proliferation of melanoma cells and induce apoptosis by activation of caspase-3 in vitro. Mar Drugs. 2011;9:2605-21 pubmed publisher
    b>Fucose-containing sulfated polysaccharides (FCSPs) extracted from seaweeds, especially brown macro-algae, are known to possess essential bioactive properties, notably growth inhibitory effects on tumor cells...
  5. Tateno H, Nakamura Tsuruta S, Hirabayashi J. Comparative analysis of core-fucose-binding lectins from Lens culinaris and Pisum sativum using frontal affinity chromatography. Glycobiology. 2009;19:527-36 pubmed publisher
    ..Glycan-binding specificities of LCA and PSA were also analyzed by glycoconjugate microarray compared to other core-fucose-binding lectins from Aspergillus oryzae (AOL) and Aleuria auratia (AAL)...
  6. Lu L, Hou X, Shi S, Korner C, Stanley P. Slc35c2 promotes Notch1 fucosylation and is required for optimal Notch signaling in mammalian cells. J Biol Chem. 2010;285:36245-54 pubmed publisher
    Mammalian Notch receptors require modification by fucose on epidermal growth factor-like (EGF) repeats of their extracellular domain to respond optimally to signal induction by canonical Notch ligands...
  7. Nakayasu S, Soegima R, Yamaguchi K, Oda T. Biological activities of fucose-containing polysaccharide ascophyllan isolated from the brown alga Ascophyllum nodosum. Biosci Biotechnol Biochem. 2009;73:961-4 pubmed
    A fucose-containing, sulfated polysaccharide ascophyllan was isolated from the brown alga Ascophyllum nodosum...
  8. Almeida Lima J, Costa L, Silva N, Melo Silveira R, Silva F, Felipe M, et al. Evaluating the possible genotoxic, mutagenic and tumor cell proliferation-inhibition effects of a non-anticoagulant, but antithrombotic algal heterofucan. J Appl Toxicol. 2010;30:708-15 pubmed publisher
    Fucan is a term used to denominate a family of sulfated polysaccharides rich in L-fucose. They are extracted mainly from brown seaweeds and echinoderms...
  9. Costa L, Fidelis G, Telles C, Dantas Santos N, Camara R, Cordeiro S, et al. Antioxidant and antiproliferative activities of heterofucans from the seaweed Sargassum filipendula. Mar Drugs. 2011;9:952-66 pubmed publisher
    Fucan is a term used to denominate a type of polysaccharide which contains substantial percentages of l-fucose and sulfate ester groups...

More Information

Publications72

  1. Cervantes Sandoval I, Jesús Serrano Luna J, Pacheco Yepez J, Silva Olivares A, Tsutsumi V, Shibayama M. Differences between Naegleria fowleri and Naegleria gruberi in expression of mannose and fucose glycoconjugates. Parasitol Res. 2010;106:695-701 pubmed publisher
    ..present high levels of surface glycoconjugates that contain alpha-D-mannose, alpha-D-glucose, and terminal alpha-L-fucose residues. A significant difference in the expression of these glycoconjugates was observed between N...
  2. Chessa D, Winter M, Jakomin M, BAUMLER A. Salmonella enterica serotype Typhimurium Std fimbriae bind terminal alpha(1,2)fucose residues in the cecal mucosa. Mol Microbiol. 2009;71:864-75 pubmed publisher
    ..These data suggest that the std operon encodes an adhesin that binds an alpha1-2 fucosylated receptor(s) present in the cecal mucosa. ..
  3. Hansman G, Shahzad ul Hussan S, McLellan J, Chuang G, Georgiev I, Shimoike T, et al. Structural basis for norovirus inhibition and fucose mimicry by citrate. J Virol. 2012;86:284-92 pubmed publisher
    ..coordinated with a set of capsid interactions almost identical to that involved in recognizing the terminal HBGA fucose, the saccharide which forms the primary conserved interaction between HBGAs and GII noroviruses...
  4. Aldi S, della Giovampaola C, Focarelli R, Armini A, Ziche M, Finetti F, et al. A fucose-containing O-glycoepitope on bovine and human nucleolin. Glycobiology. 2009;19:337-43 pubmed publisher
    ..The function and immunological properties of gp273 mainly depend on clustered Lewis-like, fucose-containing O-glycans...
  5. Orczyk Pawiłowicz M, Katnik Prastowska I. Terminal monosaccharide expression on amniotic glycoproteins as biomarkers of fetus maturity. Biochem Soc Trans. 2011;39:344-8 pubmed publisher
    Glycotypes, particularly those that terminate with sialic acid and fucose are known to play a fundamental role in human development, during implantation, growth and differentiation of fetal tissues...
  6. Hauber H, Schulz M, Pforte A, Mack D, Zabel P, Schumacher U. Inhalation with fucose and galactose for treatment of Pseudomonas aeruginosa in cystic fibrosis patients. Int J Med Sci. 2008;5:371-6 pubmed
    ..We hypothesized that P. aeruginosa lung infection should be cleared by inhalation of fucose and galactose, which compete for the sugar binding site of the two lectins and thus inhibit the binding of P...
  7. CHUNG S, Quarmby V, Gao X, Ying Y, Lin L, Reed C, et al. Quantitative evaluation of fucose reducing effects in a humanized antibody on Fc? receptor binding and antibody-dependent cell-mediated cytotoxicity activities. MAbs. 2012;4:326-40 pubmed publisher
    The presence or absence of core fucose in the Fc region N-linked glycans of antibodies affects their binding affinity toward Fc?RIIIa as well as their antibody-dependent cell-mediated cytotoxicity (ADCC) activity...
  8. Miyoshi E, Shinzaki S, Moriwaki K, Matsumoto H. Identification of fucosylated haptoglobin as a novel tumor marker for pancreatic cancer and its possible application for a clinical diagnostic test. Methods Enzymol. 2010;478:153-64 pubmed publisher
    ..In this review, we would like to summarize the history of the identification of fucosylated haptoglobin as a marker for pancreatic cancer and its possible application for a clinical diagnostic test. ..
  9. Comunale M, Wang M, Hafner J, Krakover J, Rodemich L, Kopenhaver B, et al. Identification and development of fucosylated glycoproteins as biomarkers of primary hepatocellular carcinoma. J Proteome Res. 2009;8:595-602 pubmed publisher
    ..The identities of those proteins containing core and outer arm fucose were identified in the serum of patients with HCC...
  10. Tsuzuki S, Uchimaru T, Mikami M. Magnitude and nature of carbohydrate-aromatic interactions: ab initio calculations of fucose-benzene complex. J Phys Chem B. 2009;113:5617-21 pubmed publisher
    The stable geometries of fucose-benzene complex and the stabilization energies by formation of the complex (E(form)) were studied by ab initio molecular orbital calculations...
  11. Johansson E, Crusz S, Kolomiets E, Buts L, Kadam R, Cacciarini M, et al. Inhibition and dispersion of Pseudomonas aeruginosa biofilms by glycopeptide dendrimers targeting the fucose-specific lectin LecB. Chem Biol. 2008;15:1249-57 pubmed publisher
    The human pathogenic bacterium Pseudomonas aeruginosa produces a fucose-specific lectin, LecB, implicated in tissue attachment and the formation of biofilms...
  12. Takahashi M, Kuroki Y, Ohtsubo K, Taniguchi N. Core fucose and bisecting GlcNAc, the direct modifiers of the N-glycan core: their functions and target proteins. Carbohydr Res. 2009;344:1387-90 pubmed publisher
    ..It is suggested that these two glycosyltransferases are involved in the conformation and the function of the modified proteins including cell-surface receptors and adhesion molecules. ..
  13. Zeitlin L, Pettitt J, Scully C, Bohorova N, Kim D, Pauly M, et al. Enhanced potency of a fucose-free monoclonal antibody being developed as an Ebola virus immunoprotectant. Proc Natl Acad Sci U S A. 2011;108:20690-4 pubmed publisher
    ..However, h-13F6 carrying complex N-glycosylation lacking core fucose exhibited superior potency (ED(50) = 3 ?g)...
  14. Iskratsch T, Braun A, Paschinger K, Wilson I. Specificity analysis of lectins and antibodies using remodeled glycoproteins. Anal Biochem. 2009;386:133-46 pubmed publisher
    ..egg extract were chosen as controls for lectin interactions with fucosylated glycans (Lewis(x) and core alpha1,3-fucose)...
  15. Osumi D, Takahashi M, Miyoshi E, Yokoe S, Lee S, Noda K, et al. Core fucosylation of E-cadherin enhances cell-cell adhesion in human colon carcinoma WiDr cells. Cancer Sci. 2009;100:888-95 pubmed publisher
    Alpha1,6-fucosyltransferase (Fut8), an enzyme that catalyzes the introduction of alpha1,6 core fucose to the innermost N-acetylglucosamine residue of the N-glycan, has been implicated in the development, immune system, and tumorigenesis...
  16. Camara R, Costa L, Fidelis G, Nobre L, Dantas Santos N, Cordeiro S, et al. Heterofucans from the brown seaweed Canistrocarpus cervicornis with anticoagulant and antioxidant activities. Mar Drugs. 2011;9:124-38 pubmed publisher
    Fucan is a term used to denominate a family of sulfated polysaccharides rich in sulfated l-fucose. We extracted six fucans from Canistrocarpus cervicornis by proteolytic digestion followed by sequential acetone precipitation...
  17. Gharzouli R, Carpéné M, Couderc F, Benguedouar A, Poinsot V. Relevance of fucose-rich extracellular polysaccharides produced by Rhizobium sullae strains nodulating Hedysarum coronarium l. legumes. Appl Environ Microbiol. 2013;79:1764-76 pubmed publisher
    ..An unusual fucose-rich EPS has been characterized. The presence of this deoxy sugar seems to be related to nodulation capacity.
  18. Rodriguez Diaz J, Rubio Del Campo A, Yebra M. Lactobacillus casei ferments the N-Acetylglucosamine moiety of fucosyl-?-1,3-N-acetylglucosamine and excretes L-fucose. Appl Environ Microbiol. 2012;78:4613-9 pubmed publisher
    ..Interestingly, L. casei excretes the L-fucose moiety during growth on Fuc-?-1,3-GlcNAc, indicating that only the N-acetylglucosamine moiety is being metabolized...
  19. Orczyk Pawiłowicz M, Hirnle L, Katnik Prastowska I. The expression of fucose isoforms of amniotic and plasma alpha-1-acid glycoprotein derived from 2nd and 3rd trimester normal pregnancies. Clin Biochem. 2009;42:1517-23 pubmed publisher
    ..The relative amounts of three fucosyl-glycotopes on AGP were analysed by lectin-ELISA using fucose-specific biotinylated lectins in 169 plasma and 178 amniotic fluid samples from normal pregnancies with ..
  20. Raju R, Hillier I, Burton N, Vincent M, Doudou S, Bryce R. The effects of perfluorination on carbohydrate-pi interactions: computational studies of the interaction of benzene and hexafluorobenzene with fucose and cyclodextrin. Phys Chem Chem Phys. 2010;12:7959-67 pubmed publisher
    ..methods (CCSD(T)) predict a slightly greater interaction energy for complexes of benzene with methane or fucose, compared to corresponding complexes involving hexafluorobenzene...
  21. Lameignere E, Shiao T, Roy R, Wimmerova M, Dubreuil F, Varrot A, et al. Structural basis of the affinity for oligomannosides and analogs displayed by BC2L-A, a Burkholderia cenocepacia soluble lectin. Glycobiology. 2010;20:87-98 pubmed publisher
    ..pathogen Burkholderia cenocepacia contains three soluble carbohydrate-binding proteins, related to the fucose-binding lectin PA-IIL from Pseudomonas aeruginosa...
  22. Makyio H, Takeuchi T, Tamura M, Nishiyama K, Takahashi H, Natsugari H, et al. Structural basis of preferential binding of fucose-containing saccharide by the Caenorhabditis elegans galectin LEC-6. Glycobiology. 2013;23:797-805 pubmed publisher
    ..LEC-6, a member of galectins of Caenorhabditis elegans, binds fucose-containing saccharides...
  23. Samsen A, Bogoevska V, Klampe B, Bamberger A, Lucka L, Horst A, et al. DC-SIGN and SRCL bind glycans of carcinoembryonic antigen (CEA) and CEA-related cell adhesion molecule 1 (CEACAM1): recombinant human glycan-binding receptors as analytical tools. Eur J Cell Biol. 2010;89:87-94 pubmed publisher
    ..Fucosyltransferase IX is the main fucosyltransferase responsible for attachment of terminal fucose, the key feature of the Le(x) structure, to CEA and CEACAM1...
  24. Omasa T, Tanaka R, Doi T, Ando M, Kitamoto Y, Honda K, et al. Decrease in antithrombin III fucosylation by expressing GDP-fucose transporter siRNA in Chinese hamster ovary cells. J Biosci Bioeng. 2008;106:168-73 pubmed publisher
    The full-length cDNA of GDP-fucose transporter (GFT) was cloned from Chinese hamster ovary (CHO) 13D-35D cells. The predicted product consisted of 366 amino acids with 86% and 92% similarities to human GFT and mouse GFT, respectively...
  25. Pacheco A, Curtis M, Ritchie J, Munera D, Waldor M, Moreira C, et al. Fucose sensing regulates bacterial intestinal colonization. Nature. 2012;492:113-7 pubmed publisher
    ..FusK senses fucose and controls expression of virulence and metabolic genes...
  26. Audfray A, Claudinon J, Abounit S, Ruvoen Clouet N, Larson G, Smith D, et al. Fucose-binding lectin from opportunistic pathogen Burkholderia ambifaria binds to both plant and human oligosaccharidic epitopes. J Biol Chem. 2012;287:4335-47 pubmed publisher
    ..Our previous work indicated that fucose on human epithelia is a frequent target for lectins and adhesins of lung pathogens (Sulák, O., Cioci, G...
  27. Wimmerova M, Kozmon S, Necasova I, Mishra S, Komárek J, Koca J. Stacking interactions between carbohydrate and protein quantified by combination of theoretical and experimental methods. PLoS ONE. 2012;7:e46032 pubmed publisher
    ..Observed results suggest that in this and similar cases the carbohydrate-receptor interaction can be driven mainly by a dispersion interaction. ..
  28. Yamaki K, Yoshino S. Aspergillus oryzae lectin induces anaphylactoid oedema and mast cell activation through its interaction with fucose of mast cell-bound non-specific IgE. Scand J Immunol. 2011;74:445-53 pubmed publisher
    We investigated whether Aspergillus oryzae lectin (AOL), a fucose-specific lectin, induces anaphylactoid reactions and mast cell activation. The injection of AOL into footpads of mice produced a dose-related acute paw oedema...
  29. Costa L, Telles C, Oliveira R, Nobre L, Dantas Santos N, Camara R, et al. Heterofucan from Sargassum filipendula induces apoptosis in HeLa cells. Mar Drugs. 2011;9:603-14 pubmed publisher
    Fucan is a term used to denominate a family of sulfated polysaccharides rich in sulfated l-fucose. Heterofucan SF-1...
  30. Donohue D, Ielasi F, Goossens K, Willaert R. The N-terminal part of Als1 protein from Candida albicans specifically binds fucose-containing glycans. Mol Microbiol. 2011;80:1667-79 pubmed publisher
    ..Under those conditions, Als1p-N binds specifically to fucose-containing glycans, which adds a lectin function to the functional diversity of the Als1 protein...
  31. Orczyk Pawiłowicz M, Hirnle L, Katnik Prastowska I. High expression of ?1,2- AND ?1,6-linked fucoses on amniotic AGP as a biomarker of fetal postmaturity risk. J Immunoassay Immunochem. 2011;32:103-13 pubmed publisher
    ..postmature and normal pregnancies with gestational ages of 41 to 42 weeks by lectin-ELISA using sialic acid- and fucose-specific biotinylated lectins...
  32. Yan S, Bleuler Martinez S, Plaza D, Kunzler M, Aebi M, Joachim A, et al. Galactosylated fucose epitopes in nematodes: increased expression in a Caenorhabditis mutant associated with altered lectin sensitivity and occurrence in parasitic species. J Biol Chem. 2012;287:28276-90 pubmed publisher
    The modification of ?1,6-linked fucose residues attached to the proximal (reducing-terminal) core N-acetylglucosamine residue of N-glycans by ?1,4-linked galactose ("GalFuc" epitope) is a feature of a number of invertebrate ..
  33. Yan Q, Yao D, Wei L, Huang Y, Myers J, Zhang L, et al. O-fucose modulates Notch-controlled blood lineage commitment. Am J Pathol. 2010;176:2921-34 pubmed publisher
  34. Lee R, Hsu T, Huang S, Hsieh S, Wong C, Lee Y. Survey of immune-related, mannose/fucose-binding C-type lectin receptors reveals widely divergent sugar-binding specificities. Glycobiology. 2011;21:512-20 pubmed publisher
    ..tripeptide motifs have potential to bind mannose (Man), N-acetylglucosamine (GlcNAc), glucose (Glc) and l-fucose (Fuc), whereas those with QPD (Glu-Pro-Asp) tripeptide motifs bind galactose (Gal) and N-acetylgalactosamine (..
  35. Junttila T, Parsons K, Olsson C, Lu Y, Xin Y, Theriault J, et al. Superior in vivo efficacy of afucosylated trastuzumab in the treatment of HER2-amplified breast cancer. Cancer Res. 2010;70:4481-9 pubmed publisher
    ..Here, we show that removing fucose from trastuzumab (Herceptin) increased its binding to FcgammaRIIIa, enhanced antibody-dependent cell-mediated ..
  36. Stahl M, Friis L, Nothaft H, Liu X, Li J, Szymanski C, et al. L-fucose utilization provides Campylobacter jejuni with a competitive advantage. Proc Natl Acad Sci U S A. 2011;108:7194-9 pubmed publisher
    ..When colonizing its hosts, C. jejuni comes into contact with intestinal carbohydrates, including L-fucose, released from mucin glycoproteins. Several strains of C...
  37. Fonseca R, Santos G, Mourao P. Effects of polysaccharides enriched in 2,4-disulfated fucose units on coagulation, thrombosis and bleeding. Practical and conceptual implications. Thromb Haemost. 2009;102:829-36 pubmed publisher
    ..The compounds share similar 2,4-disulfated fucose units, which are required for high anticoagulant activity in this class of polymer...
  38. Ferrara C, Grau S, Jäger C, Sondermann P, Brünker P, Waldhauer I, et al. Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgammaRIII and antibodies lacking core fucose. Proc Natl Acad Sci U S A. 2011;108:12669-74 pubmed publisher
    ..These findings allow us to understand the higher efficacy of therapeutic antibodies lacking the core fucose and also suggest a unique mechanism by which the immune system can regulate antibody-mediated effector functions.
  39. Sawke N, Sawke G. Serum fucose level in malignant diseases. Indian J Cancer. 2010;47:452-7 pubmed publisher
    We review the present knowledge of serum fucose with special attention to its relation with various malignant diseases. We summarize the role of serum fucose as a useful diagnostic and prognostic marker when used singly or in combination...
  40. Sulák O, Cioci G, Lameignere E, Balloy V, Round A, Gutsche I, et al. Burkholderia cenocepacia BC2L-C is a super lectin with dual specificity and proinflammatory activity. PLoS Pathog. 2011;7:e1002238 pubmed publisher
    ..The N-terminal domain is a novel TNF-?-like fucose-binding lectin, while the C-terminal part is similar to a superfamily of calcium-dependent bacterial lectins...
  41. Nakagawa M, Tojo H, Fujii S. A glycan of ?-factor from Dictyostelium discoideum contains a bisecting-GlcNAc, an intersecting-GlcNAc, and a core ?-1,6-fucose. Biosci Biotechnol Biochem. 2011;75:1964-70 pubmed
  42. Aplin J, Jones C. Fucose, placental evolution and the glycocode. Glycobiology. 2012;22:470-8 pubmed publisher
    A family of 13 fucosyltransferase genes has evolved to catalyze the addition of fucose in various linkage positions to nascent glycoproteins...
  43. Jia W, Lu Z, Fu Y, Wang H, Wang L, Chi H, et al. A strategy for precise and large scale identification of core fucosylated glycoproteins. Mol Cell Proteomics. 2009;8:913-23 pubmed publisher
  44. Titz A, Butschi A, Henrissat B, Fan Y, Hennet T, Razzazi Fazeli E, et al. Molecular basis for galactosylation of core fucose residues in invertebrates: identification of caenorhabditis elegans N-glycan core alpha1,6-fucoside beta1,4-galactosyltransferase GALT-1 as a member of a novel glycosyltransferase family. J Biol Chem. 2009;284:36223-33 pubmed publisher
    ..elegans strain characterized by N-glycans lacking the beta1,4-galactoside linked to the alpha1,6-linked core fucose. Expression of the corresponding GALT-1 protein in insect cells was used to demonstrate a manganese-dependent ..
  45. Sugihara J, Sun L, Yan N, Kaback H. Dynamics of the L-fucose/H+ symporter revealed by fluorescence spectroscopy. Proc Natl Acad Sci U S A. 2012;109:14847-51 pubmed publisher
    FucP of Escherichia coli catalyzes L-fucose/H(+) symport, and a crystal structure in an outward-facing conformation has been reported. However, nothing is known about FucP conformational dynamics...
  46. Stefan van Staden R, Nejem R, van Staden J, Aboul Enein H. Determination of L- and D-fucose using amperometric electrodes based on diamond paste. Analyst. 2012;137:903-9 pubmed publisher
    ..diamond, synthetic-1 and synthetic-2) based electrochemical electrodes were designed for the analysis of L- and D-fucose. Response characteristics of the electrochemical electrodes were determined using cyclic voltammetry and ..
  47. Kratz E, Faundez R, Katnik Prastowska I. Fucose and sialic acid expressions in human seminal fibronectin and ?{1} -acid glycoprotein associated with leukocytospermia of infertile men. Dis Markers. 2011;31:317-25 pubmed publisher
    The aim of this study was to compare fucose and sialic acid residue expression on fibronectin and ?{1}-acid glycoprotein in the seminal plasma of men suspected of infertility and suffering from leukocytospermia...
  48. Tsuzuki S, Uchimaru T, Mikami M. Magnitude and nature of carbohydrate-aromatic interactions in fucose-phenol and fucose-indole complexes: CCSD(T) level interaction energy calculations. J Phys Chem A. 2011;115:11256-62 pubmed publisher
    The CH/? contact structures of the fucose-phenol and fucose-indole complexes and the stabilization energies by formation of the complexes (E(form)) were studied by ab initio molecular orbital calculations...
  49. Muraoka W, Zhang Q. Phenotypic and genotypic evidence for L-fucose utilization by Campylobacter jejuni. J Bacteriol. 2011;193:1065-75 pubmed publisher
    ..Contrary to this paradigm, we provide evidence for l-fucose utilization by C. jejuni...
  50. Dang S, Sun L, Huang Y, Lu F, Liu Y, Gong H, et al. Structure of a fucose transporter in an outward-open conformation. Nature. 2010;467:734-8 pubmed publisher
    ..In Escherichia coli, the uptake of l-fucose, a source of carbon for microorganisms, is mediated by an MFS proton symporter, FucP...
  51. Petit E, Latouf W, Coppi M, Warnick T, Currie D, Romashko I, et al. Involvement of a bacterial microcompartment in the metabolism of fucose and rhamnose by Clostridium phytofermentans. PLoS ONE. 2013;8:e54337 pubmed publisher
    ..The genome of C. phytofermentans contains three loci with genes encoding shell proteins of bacterial microcompartments (BMC), organelles composed entirely of proteins...
  52. Keeney K, Finlay B. Microbiology: EHEC downregulates virulence in response to intestinal fucose. Curr Biol. 2013;23:R108-10 pubmed publisher
    ..revealed that enterohaemorrhagic Escherichia coli encodes a two-component system, termed FusKR, which responds to fucose and represses expression of virulence genes...
  53. Al Shareffi E, Chaubard J, Leonhard Melief C, Wang S, Wong C, Haltiwanger R. 6-alkynyl fucose is a bioorthogonal analog for O-fucosylation of epidermal growth factor-like repeats and thrombospondin type-1 repeats by protein O-fucosyltransferases 1 and 2. Glycobiology. 2013;23:188-98 pubmed publisher
    Protein O-fucosyltransferase 1 (Pofut1) and protein O-fucosyltransferase 2 (Pofut2) add O-linked fucose at distinct consensus sequences in properly folded epidermal growth factor (EGF)-like repeats and thrombospondin type-1 (TSR) repeats, ..
  54. Liao S, Liang C, Ho M, Hsu T, Tsai T, Hsieh Y, et al. Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes. Proc Natl Acad Sci U S A. 2013;110:13809-14 pubmed publisher
    ..Here, we show that the mice immunized with a l-fucose (Fuc)-enriched Reishi polysaccharide fraction (designated as FMS) induce antibodies against murine Lewis lung ..
  55. Ayukawa T, Matsumoto K, Ishikawa H, Ishio A, Yamakawa T, Aoyama N, et al. Rescue of Notch signaling in cells incapable of GDP-L-fucose synthesis by gap junction transfer of GDP-L-fucose in Drosophila. Proc Natl Acad Sci U S A. 2012;109:15318-23 pubmed
    ..N contains EGF-like repeats, many of which have an O-fucose glycan modification that regulates N-ligand binding. This modification requires GDP-L-fucose as a donor of fucose...
  56. Ale M, Mikkelsen J, Meyer A. Important determinants for fucoidan bioactivity: a critical review of structure-function relations and extraction methods for fucose-containing sulfated polysaccharides from brown seaweeds. Mar Drugs. 2011;9:2106-30 pubmed publisher
    ..Fucoidan designates a group of certain fucose-containing sulfated polysaccharides (FCSPs) that have a backbone built of (1?3)-linked ?-L-fucopyranosyl or of ..
  57. Soriano Del Amo D, Wang W, Jiang H, Besanceney C, Yan A, Levy M, et al. Biocompatible copper(I) catalysts for in vivo imaging of glycans. J Am Chem Soc. 2010;132:16893-9 pubmed publisher
    ..We microinjected embryos with alkyne-bearing GDP-fucose at the one-cell stage and detected the metabolically incorporated unnatural sugars using the biocompatible click ..
  58. Sulák O, Cioci G, Delia M, Lahmann M, Varrot A, Imberty A, et al. A TNF-like trimeric lectin domain from Burkholderia cenocepacia with specificity for fucosylated human histo-blood group antigens. Structure. 2010;18:59-72 pubmed publisher
  59. Karg S, Frey A, Kallio P. Reduction of N-linked xylose and fucose by expression of rat beta1,4-N-acetylglucosaminyltransferase III in tobacco BY-2 cells depends on Golgi enzyme localization domain and genetic elements used for expression. J Biotechnol. 2010;146:54-65 pubmed publisher
    Plant-specific N-glycosylation, such as the introduction of core alpha1,3-fucose and beta1,2-xylose residues, is a major obstacle to the utilization of plant cell- or plant-derived recombinant therapeutic proteins...
  60. Snider T, Fabich A, Conway T, Clinkenbeard K. E. coli O157:H7 catabolism of intestinal mucin-derived carbohydrates and colonization. Vet Microbiol. 2009;136:150-4 pubmed publisher
    ..coli O157:H7 and isogenic mutants in catabolic pathways for mucin-derived carbohydrates N-acetylgalactosamine or l-fucose. Both mutants colonized poorly compared to the wild-type during the initiation stage of colonization (days 0-6)...
  61. Kobayashi Y, Tateno H, Dohra H, Moriwaki K, Miyoshi E, Hirabayashi J, et al. A novel core fucose-specific lectin from the mushroom Pholiota squarrosa. J Biol Chem. 2012;287:33973-82 pubmed publisher
    ..Thus, PhoSL will be a promising tool for analyzing the biological functions of ?1-6 fucosylation and evaluating Fuc?1-6 oligosaccharides as cancer biomarkers. ..
  62. Anderson C, Wallace I, Somerville C. Metabolic click-labeling with a fucose analog reveals pectin delivery, architecture, and dynamics in Arabidopsis cell walls. Proc Natl Acad Sci U S A. 2012;109:1329-34 pubmed publisher
    ..Using this approach, we found that an alkynylated fucose analog (FucAl) is metabolically incorporated into the cell walls of Arabidopsis thaliana roots and that a ..
  63. Pan P, Chen H, Wu P, Wu Y, Lin C, Wu J. Mutation in fucose synthesis gene of Klebsiella pneumoniae affects capsule composition and virulence in mice. Exp Biol Med (Maywood). 2011;236:219-26 pubmed publisher
    ..A unique property of KP is its thick mucoid capsule. The bacterial capsule has been found to contain fucose in KP strains causing LA but not in those causing urinary tract infections...