submitochondrial particles

Summary

Summary: The various filaments, granules, tubules or other inclusions within mitochondria.

Top Publications

  1. Paradies G, Petrosillo G, Pistolese M, Ruggiero F. The effect of reactive oxygen species generated from the mitochondrial electron transport chain on the cytochrome c oxidase activity and on the cardiolipin content in bovine heart submitochondrial particles. FEBS Lett. 2000;466:323-6 pubmed
    ..chain, on the activity of cytochrome c oxidase and on the cardiolipin content in bovine heart submitochondrial particles (SMP) was studied. ROS were produced by treatment of succinate-respiring SMP with antimycin A...
  2. Galkin A, Grivennikova V, Vinogradov A. H+/2e- stoichiometry of the nadh:ubiquinone reductase reaction catalyzed by submitochondrial particles. Biochemistry (Mosc). 2001;66:435-43 pubmed
    Mitochondrial NADH:ubiquinone-reductase (Complex I) catalyzes proton translocation into inside-out submitochondrial particles. Here we describe a method for determining the stoichiometric ratio H+/2e- (n) for the coupled reaction of NADH ..
  3. Lucca G, Comim C, Valvassori S, Réus G, Vuolo F, Petronilho F, et al. Increased oxidative stress in submitochondrial particles into the brain of rats submitted to the chronic mild stress paradigm. J Psychiatr Res. 2009;43:864-9 pubmed publisher
    ..We also investigated the potential involvement of ROS in the CMS model. Superoxide generation in submitochondrial particles from the rat hippocampus, prefrontal cortex and cortex was measured through superoxide-dependent ..
  4. Martínez Cano E, Ortiz Genaro G, Pacheco Moisés F, Macias Islas M, Sanchez Nieto S, Rosales Corral S. [Functional disorders of FOF1-ATPase in submitochondrial particles obtained from platelets of patients with a diagnosis of probable Alzheimer's disease]. Rev Neurol. 2005;40:81-5 pubmed
    ..Recent studies indicate that decreased energy generation by mitochondria is a feature that is common across neurodegenerative diseases...
  5. Valez V, Cassina A, Batinic Haberle I, Kalyanaraman B, Ferrer Sueta G, Radi R. Peroxynitrite formation in nitric oxide-exposed submitochondrial particles: detection, oxidative damage and catalytic removal by Mn-porphyrins. Arch Biochem Biophys. 2013;529:45-54 pubmed publisher
    ..Herein, a model system of submitochondrial particles (SMP) in the presence of succinate plus the respiratory inhibitor antimycin A (to increase O(2)(?-) ..
  6. Thomas C, Mackey M, Diaz A, Cox D. Hydroxyl radical is produced via the Fenton reaction in submitochondrial particles under oxidative stress: implications for diseases associated with iron accumulation. Redox Rep. 2009;14:102-8 pubmed publisher
    ..whether HO(*) is generated under oxidative stress conditions by a Fenton-type mechanism, bovine heart submitochondrial particles were examined for HO(*) in the presence and absence of iron ligands, antioxidant enzymes and HO(*) ..
  7. Ortiz G, Pacheco Moisés F, El Hafidi M, Jiménez Delgado A, Macias Islas M, Rosales Corral S, et al. Detection of membrane fluidity in submitochondrial particles of platelets and erythrocyte membranes from Mexican patients with Alzheimer disease by intramolecular excimer formation of 1,3 dipyrenylpropane. Dis Markers. 2008;24:151-6 pubmed
    ..The data obtained showed that in submitochondrial particles from AD patients, the excimer to monomer fluorescent intensity ratio was lower (0.231 +/- 0...
  8. de Oliveira M, Moreira J. Acute and chronic vitamin A supplementation at therapeutic doses induces oxidative stress in submitochondrial particles isolated from cerebral cortex and cerebellum of adult rats. Toxicol Lett. 2007;173:145-50 pubmed
    ..Here, we show that acute and chronic vitamin A supplementation induces oxidative stress to submitochondrial particles (SMP) isolated from rat cerebral cortex and cerebellum...
  9. Frey B, Valvassori S, Gomes K, Martins M, Dal Pizzol F, Kapczinski F, et al. Increased oxidative stress in submitochondrial particles after chronic amphetamine exposure. Brain Res. 2006;1097:224-9 pubmed
    ..We studied the effects of acute and chronic d-amphetamine on ROS production in submitochondrial particles of rat brain. Male Wistar rats were divided in two experimental groups: acute and chronic treatment...

More Information

Publications62

  1. Sohal R. Coenzyme Q and vitamin E interactions. Methods Enzymol. 2004;378:146-51 pubmed
  2. Garrido N, Griparic L, Jokitalo E, Wartiovaara J, van der Bliek A, Spelbrink J. Composition and dynamics of human mitochondrial nucleoids. Mol Biol Cell. 2003;14:1583-96 pubmed
    ..Nucleoids did not colocalize with dynamin-related protein 1, Drp1, a protein of the mitochondrial fission machinery...
  3. Forsmark Andrée P, Persson B, Radi R, Dallner G, Ernster L. Oxidative modification of nicotinamide nucleotide transhydrogenase in submitochondrial particles: effect of endogenous ubiquinol. Arch Biochem Biophys. 1996;336:113-20 pubmed
    ..Endogenous ubiquinol may play a role in protecting the enzyme against agents perturbing the lipid phase of the membrane...
  4. Gresser M. ADP-arsenate. Formation by submitochondrial particles under phosphorylating conditions. J Biol Chem. 1981;256:5981-3 pubmed
    b>Submitochondrial particles from beef heart mitochondria synthesize ADP-arsenate from ADP and arsenate when energized by succinate...
  5. Knobeloch L, Blondin G, Harkin J. Use of submitochondrial particles for prediction of chemical toxicity in man. Bull Environ Contam Toxicol. 1990;44:661-8 pubmed
  6. Moreno Sanchez R, Bravo C, Vasquez C, Ayala G, Silveira L, Martinez Lavin M. Inhibition and uncoupling of oxidative phosphorylation by nonsteroidal anti-inflammatory drugs: study in mitochondria, submitochondrial particles, cells, and whole heart. Biochem Pharmacol. 1999;57:743-52 pubmed
    ..NADH oxidation in submitochondrial particles also was inhibited by nabumetone...
  7. Bhattacharya P. 3D model of RNA polymerase and bidirectional transcription. Biochem Biophys Res Commun. 2007;355:103-10 pubmed
    ..But this in vitro reconstituted transcription system was not studied beyond the D-loop region. A 3D model of the enzyme RNA polymerase was docked with both ATP and CTP...
  8. Walzel B, Speer O, Zanolla E, Eriksson O, Bernardi P, Wallimann T. Novel mitochondrial creatine transport activity. Implications for intracellular creatine compartments and bioenergetics. J Biol Chem. 2002;277:37503-11 pubmed
    ..Our data suggest that mitochondria, shown here to possess creatine transport activity, may harbor such a creatine/phosphocreatine pool...
  9. Fato R, Bergamini C, Leoni S, Lenaz G. Mitochondrial production of reactive oxygen species: role of complex I and quinone analogues. Biofactors. 2008;32:31-9 pubmed
  10. Mei S. Multi-kernel transfer learning based on Chou's PseAAC formulation for protein submitochondria localization. J Theor Biol. 2012;293:121-30 pubmed publisher
  11. Murai M, Ishihara A, Nishioka T, Yagi T, Miyoshi H. The ND1 subunit constructs the inhibitor binding domain in bovine heart mitochondrial complex I. Biochemistry. 2007;46:6409-16 pubmed
    ..acetogenins, and carried out photoaffinity labeling to identify the labeled subunit using bovine heart submitochondrial particles (SMP)...
  12. Augereau O, Claverol S, Boudes N, Basurko M, Bonneu M, Rossignol R, et al. Identification of tyrosine-phosphorylated proteins of the mitochondrial oxidative phosphorylation machinery. Cell Mol Life Sci. 2005;62:1478-88 pubmed
    ..The tyrosine phosphatase PTP 1B was found in brain but not in muscle, heart or liver mitochondria. Our results suggest that tyrosine kinases and phosphatases are involved in the regulation of oxidative phosphorylation...
  13. Sato T, Mihara K. Topogenesis of mammalian Oxa1, a component of the mitochondrial inner membrane protein export machinery. J Biol Chem. 2009;284:14819-27 pubmed publisher
    ..Together, these results demonstrated that topogenesis of Oxa1 is a cooperative event of all five TMs, and GLPWWG followed immediately by TM1 is essential for correct Oxa1 topogenesis...
  14. Yan L, Christians E, Liu L, Xiao X, Sohal R, Benjamin I. Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damage. EMBO J. 2002;21:5164-72 pubmed
  15. Arrington D, Van Vleet T, Schnellmann R. Calpain 10: a mitochondrial calpain and its role in calcium-induced mitochondrial dysfunction. Am J Physiol Cell Physiol. 2006;291:C1159-71 pubmed
    ..In conclusion, calpain 10 is the first reported mitochondrially targeted calpain and is a mediator of mitochondrial dysfunction through the cleavage of Complex I subunits and activation of MPT...
  16. Theodossiou T, Papakyriakou A, Hothersall J. Molecular modeling and experimental evidence for hypericin as a substrate for mitochondrial complex III; mitochondrial photodamage as demonstrated using specific inhibitors. Free Radic Biol Med. 2008;45:1581-90 pubmed publisher
    ..Using submitochondrial particles we examined hypericin as a possible substrate of complex III and compared this to its natural substrate, ..
  17. Lotina Hennsen B, Gonzalez Halphen D, Uribe S, Rangel P, Gomez Lojero C. DBHBM (3,5-dibromo-4-hydroxy-benzylidenemalonitrile) is a novel inhibitor of electron transfer through the QN center of the mitochondrial bc1 complex. Arch Biochem Biophys. 1995;318:200-6 pubmed
    ..inhibited the NADH- or succinate-supported rate of O2 consumption in beef heart submitochondrial particles (Ki = 7 x 10(-7) M)...
  18. Martins O, Tuena de Gomez Puyou M, Gomez Puyou A. Pre-steady-state studies of the adenosine triphosphatase activity of coupled submitochondrial particles. Regulation by ADP. Biochemistry. 1988;27:7552-8 pubmed
    ATPase activities were measured in 10 mM MgCl2, 5 mM ATP, 1 mM ADP, and 1 microM FCCP with submitochondrial particles from bovine heart that had been stimulated by delta mu H+-forming substrates and with particles whose natural inhibitor ..
  19. Hung C, Ho Y, Chang R. Modulation of mitochondrial calcium as a pharmacological target for Alzheimer's disease. Ageing Res Rev. 2010;9:447-56 pubmed publisher
    ..Modulation of mitochondrial Ca(2+) handling is a potential pharmacological target for future development of AD treatments...
  20. Murai M, Ichimaru N, Abe M, Nishioka T, Miyoshi H. Mode of inhibitory action of Deltalac-acetogenins, a new class of inhibitors of bovine heart mitochondrial complex I. Biochemistry. 2006;45:9778-87 pubmed
    ..The unique inhibitory action of hydrophobic Deltalac-acetogenins may be closely associated with the dynamic function of the membrane domain of complex I...
  21. Jezek P, Mahdi F, Garlid K. Reconstitution of the beef heart and rat liver mitochondrial K+/H+ (Na+/H+) antiporter. Quantitation of K+ transport with the novel fluorescent probe, PBFI. J Biol Chem. 1990;265:10522-6 pubmed
  22. Medentsev A, Arinbasarova A, Smirnova N, Akimenko V. [Activation of the alternative oxidase of Yarrowia lipolytica by adenosine 5'-monophosphate]. Mikrobiologiia. 2004;73:149-56 pubmed
    ..effect of nucleoside phosphates on the activity of cyanide-resistant oxidase in the mitochondria and the submitochondrial particles of Yarrowia lipolytica showed that adenosine monophosphate (5'-AMP, AMP) did not stimulate the ..
  23. Shiraishi Y, Murai M, Sakiyama N, Ifuku K, Miyoshi H. Fenpyroximate binds to the interface between PSST and 49 kDa subunits in mitochondrial NADH-ubiquinone oxidoreductase. Biochemistry. 2012;51:1953-63 pubmed publisher
    ..This study answers a critical question relating to complex I...
  24. Yabunaka H, Kenmochi A, Nakatogawa Y, Sakamoto K, Miyoshi H. Hybrid ubiquinone: novel inhibitor of mitochondrial complex I. Biochim Biophys Acta. 2002;1556:106-12 pubmed
    ..It is of interest that an analogous bulky and hydrophobic substructure can be commonly found in recently registered synthetic pesticides the action site of which is mitochondrial complex I...
  25. Lapointe J, Wang Y, Bigras E, Hekimi S. The submitochondrial distribution of ubiquinone affects respiration in long-lived Mclk1+/- mice. J Cell Biol. 2012;199:215-24 pubmed publisher
    ..These findings indicate that MCLK1 regulates both UQ synthesis and distribution within mitochondrial membranes...
  26. Joubert F, Vrezas I, Mateo P, Gillet B, Beloeil J, Soboll S, et al. Cardiac creatine kinase metabolite compartments revealed by NMR magnetization transfer spectroscopy and subcellular fractionation. Biochemistry. 2001;40:2129-37 pubmed
    ..Thus NMR inversion technique is a potential tool to assess metabolite compartmentation in the whole organ...
  27. Ferreira G, Pratt R, Pedersen P. Mitochondrial proton/phosphate transporter. An antibody directed against the COOH terminus and proteolytic cleavage experiments provides new insights about its membrane topology. J Biol Chem. 1990;265:21202-6 pubmed
    ..In addition, they support the view that alkylation of a reactive cysteine residue induces a significant conformational change in the transporter...
  28. Pellon Maison M, Montanaro M, Coleman R, GONZALEZ BARO M. Mitochondrial glycerol-3-P acyltransferase 1 is most active in outer mitochondrial membrane but not in mitochondrial associated vesicles (MAV). Biochim Biophys Acta. 2007;1771:830-8 pubmed
  29. Mingatto F, Dorta D, dos Santos A, Carvalho I, da Silva C, da Silva V, et al. Dehydromonocrotaline inhibits mitochondrial complex I. A potential mechanism accounting for hepatotoxicity of monocrotaline. Toxicon. 2007;50:724-30 pubmed
    ..levels in isolated rat liver mitochondria, and on respiratory chain complex I NADH oxidase activity in submitochondrial particles. Dehydromonocrotaline, but not the parent compound, showed a concentration-dependent inhibition of ..
  30. Chung K, Cho K, Asami Y, Takahashi N, Yoshida S. New 4-hydroxypyridine and 4-hydroxyquinoline derivatives as inhibitors of NADH-ubiquinone reductase in the respiratory chain. Z Naturforsch C. 1989;44:609-16 pubmed
    ..4-Hydroxyquinoline derivatives were also tested for an analogous role in relation to the electron transport function of menaquinone, and they were proven to be inhibitors of NADH-UQ reductase as good as the pyridine derivatives...
  31. Ramsay R, Singer T. Relation of superoxide generation and lipid peroxidation to the inhibition of NADH-Q oxidoreductase by rotenone, piericidin A, and MPP+. Biochem Biophys Res Commun. 1992;189:47-52 pubmed
    The addition of NADH to submitochondrial particles inhibited by agents which interrupt electron transport from NADH-Q oxidoreductase (Complex I) to Q10 (rotenone, piericidin A, and MPP+) results in superoxide formation and lipid ..
  32. Singh R, Kumar S, Nada R, Prasad R. Evaluation of copper toxicity in isolated human peripheral blood mononuclear cells and it's attenuation by zinc: ex vivo. Mol Cell Biochem. 2006;282:13-21 pubmed
    ..Taken together, the results of our study demonstrates that zinc play an important role in prevention of copper toxicity in peripheral blood mononuclear cells...
  33. D Souza G, Boddapati S, Weissig V. Mitochondrial leader sequence--plasmid DNA conjugates delivered into mammalian cells by DQAsomes co-localize with mitochondria. Mitochondrion. 2005;5:352-8 pubmed
  34. Nakanishi S, Abe M, Yamamoto S, Murai M, Miyoshi H. Bis-THF motif of acetogenin binds to the third matrix-side loop of ND1 subunit in mitochondrial NADH-ubiquinone oxidoreductase. Biochim Biophys Acta. 2011;1807:1170-6 pubmed publisher
    ..Analysis of the photocross-linked protein in bovine heart submitochondrial particles unambiguously revealed that [(125)I]DANA binds to the membrane subunit ND1 with high specificity...
  35. Taniguchi M, Hara T, Honda H. Similarities between rat liver mitochondrial and cytosolic glutathione reductases and their apoenzyme accumulation in riboflavin deficiency. Biochem Int. 1986;13:447-54 pubmed
  36. Smith H, Ahmed A, Millett F. Electrostatic interaction of cytochrome c with cytochrome c1 and cytochrome oxidase. J Biol Chem. 1981;256:4984-90 pubmed
    ..The electrostatic energies of interaction between cytochrome c and its reductase and oxidase were nearly the same, providing additional evidence that the two reactions take place at similar sites on cytochrome c...
  37. Grivennikova V, Serebryanaya D, Isakova E, Belozerskaya T, Vinogradov A. The transition between active and de-activated forms of NADH:ubiquinone oxidoreductase (Complex I) in the mitochondrial membrane of Neurospora crassa. Biochem J. 2003;369:619-26 pubmed
    ..We conclude that continuous slow cycling between A and D forms occurs during the steady-state operation of Complex I in N. crassa mitochondria...
  38. Armson A, Grubb W, Mendis A. Strongyloides ratti: mitochondrial enzyme activities of the classical electron transport pathway in the infective (L3) larvae. Int J Parasitol. 1995;25:257-60 pubmed
    b>Submitochondrial particles prepared from S...
  39. Sled V, Vinogradov A. Kinetics of the mitochondrial NADH-ubiquinone oxidoreductase interaction with hexammineruthenium(III). Biochim Biophys Acta. 1993;1141:262-8 pubmed
    ..hexammineruthenium was found to be an efficient electron acceptor for the enzyme in inside-out submitochondrial particles and isolated Complex I, but not in intact mitochondria...
  40. Yu L, Wei Y, Usui S, Yu C. Cytochrome b560 (QPs1) of mitochondrial succinate-ubiquinone reductase. Immunochemistry, cloning, and nucleotide sequencing. J Biol Chem. 1992;267:24508-15 pubmed
    ..The purified antibodies inhibited 75% of the reconstitutive activity of QPs and reacted with both submitochondrial particles (SMP) and mitoplasts...
  41. Maas M, Krause F, Dencher N, Sainsard Chanet A. Respiratory complexes III and IV are not essential for the assembly/stability of complex I in fungi. J Mol Biol. 2009;387:259-69 pubmed publisher
    ..In summary, we present the first obligatorily aerobic eukaryote with an artificial, simultaneous lack of the respiratory complexes III and IV...
  42. Ardail D, Gasnier F, Lerme F, Simonot C, Louisot P, Gateau Roesch O. Involvement of mitochondrial contact sites in the subcellular compartmentalization of phospholipid biosynthetic enzymes. J Biol Chem. 1993;268:25985-92 pubmed
    ..These results show that the interorganelle trafficking of lipids may involve only highly specialized microdomains of both membranes, thereby allowing the maintenance of a specific lipid composition and distribution within membranes...
  43. de Oliveira M, Oliveira M, Lorenzi R, Fagundes da Rocha R, Fonseca Moreira J. Short-term vitamin A supplementation at therapeutic doses induces a pro-oxidative state in the hepatic environment and facilitates calcium-ion-induced oxidative stress in rat liver mitochondria independently from permeability transition pore formatio. Cell Biol Toxicol. 2009;25:545-60 pubmed publisher
    ..dysfunction was found since superoxide anion production was increased in vitamin-A-treated rat liver submitochondrial particles, which may be the result of impaired mitochondrial electron transfer chain activity, as assessed here...
  44. Vintonyak V, Kunze B, Sasse F, Maier M. Total synthesis and biological activity of neopeltolide and analogues. Chemistry. 2008;14:11132-40 pubmed publisher
    ..were checked for toxicity effects on mammalian cell cultures and inhibitory effects on NADH oxidation in submitochondrial particles of bovine heart. Modifications in the lactone part are tolerated to some degree...
  45. Czerniczyniec A, Bustamante J, Lores Arnaiz S. Improvement of mouse brain mitochondrial function after deprenyl treatment. Neuroscience. 2007;144:685-93 pubmed
    ..In addition, the effect of deprenyl on respiratory complexes and MAO activities were evaluated in submitochondrial particles (SMP)...
  46. McDonald Marsh T, Carroll C, Robinson N, Musatov A. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis of cardiolipin extracted from detergent-solubilized mitochondrial electron transfer complexes. Anal Biochem. 2006;359:262-4 pubmed
  47. Sun C, Zhang X, Sheard P, Mabuchi A, Wheatley A. Change in mitochondrial membrane potential is the key mechanism in early warm hepatic ischemia-reperfusion injury. Microvasc Res. 2005;70:102-10 pubmed
    ..90, P<0.05). Our data suggested that alteration in mitochondrial membrane potential is a critical subcellular event leading to hepatocellular damage in the early phase of hepatic IR injury...
  48. Hachiya N, Yamada M, Watanabe K, Jozuka A, Ohkubo T, Sano K, et al. Mitochondrial localization of cellular prion protein (PrPC) invokes neuronal apoptosis in aged transgenic mice overexpressing PrPC. Neurosci Lett. 2005;374:98-103 pubmed
    ..Hence, the neurotoxic property of PrPC could be explained by the mitochondria-mediated neuronal apoptosis, at least in part...
  49. Quintanilla M, Tampier L, Valle Prieto A, Sapag A, Israel Y. Complex I regulates mutant mitochondrial aldehyde dehydrogenase activity and voluntary ethanol consumption in rats. FASEB J. 2005;19:36-42 pubmed
    ..This is the first demonstration that maternally derived genes can either allow or counteract the phenotypic expression of a mutated gene in the context of alcohol abuse or alcoholism..
  50. Schwer B, North B, Frye R, Ott M, Verdin E. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol. 2002;158:647-57 pubmed
    ..These observations demonstrate the existence of a latent class III deacetylase that becomes catalytically activated upon import into the human mitochondria...
  51. McMullin T, Fox T. COX3 mRNA-specific translational activator proteins are associated with the inner mitochondrial membrane in Saccharomyces cerevisiae. J Biol Chem. 1993;268:11737-41 pubmed
    ..Amino-terminal sequencing of proteins isolated from mitochondria revealed that PET54 is not processed during import to mitochondria while the PET122 precursor is cleaved between the 8th and 9th residues...
  52. Grivennikova V, Kotlyar A, Karliner J, Cecchini G, Vinogradov A. Redox-dependent change of nucleotide affinity to the active site of the mammalian complex I. Biochemistry. 2007;46:10971-8 pubmed
    ..the interaction of NADH-OH and other nucleotides with oxidized and reduced complex I in tightly coupled submitochondrial particles. Both the rate of the NADH-OH binding and its affinity to complex I are strongly decreased in the ..
  53. Miyakawa I, Sato H, Maruyama Y, Nakaoka T. Isolation of the mitochondrial nucleoids from yeast Kluyveromyces lactis and analyses of the nucleoid proteins. J Gen Appl Microbiol. 2003;49:85-93 pubmed
    ..lactis and plays structural roles in compacting mtDNA in cooperation with other nucleoid proteins...