trans golgi network

Summary

Summary: A network of membrane compartments, located at the cytoplasmic side of the GOLGI APPARATUS, where proteins and lipids are sorted for transport to various locations in the cell or cell membrane.

Top Publications

  1. Bard F, Malhotra V. The formation of TGN-to-plasma-membrane transport carriers. Annu Rev Cell Dev Biol. 2006;22:439-55 pubmed
    ..We discuss these issues with regard to TGN-to-cell-surface transport carriers...
  2. De Matteis M, Luini A. Exiting the Golgi complex. Nat Rev Mol Cell Biol. 2008;9:273-84 pubmed publisher
  3. Alroy I, Tuvia S, Greener T, Gordon D, Barr H, Taglicht D, et al. The trans-Golgi network-associated human ubiquitin-protein ligase POSH is essential for HIV type 1 production. Proc Natl Acad Sci U S A. 2005;102:1478-83 pubmed
    ..Consequently, hPOSH may be a useful host target for therapeutic intervention...
  4. Bujny M, Popoff V, Johannes L, Cullen P. The retromer component sorting nexin-1 is required for efficient retrograde transport of Shiga toxin from early endosome to the trans Golgi network. J Cell Sci. 2007;120:2010-21 pubmed
    ..transport of the cation-independent mannose 6-phosphate receptor (CI-MPR) from early endosomes to the trans Golgi network (TGN)...
  5. Abazeed M, Blanchette J, Fuller R. Cell-free transport from the trans-golgi network to late endosome requires factors involved in formation and consumption of clathrin-coated vesicles. J Biol Chem. 2005;280:4442-50 pubmed
    ..Further biochemical dissection of this reaction should help elucidate the molecular requirements and hierarchy of events in TGN-to-PVC sorting and transport...
  6. Chambers K, Judson B, Brown W. A unique lysophospholipid acyltransferase (LPAT) antagonist, CI-976, affects secretory and endocytic membrane trafficking pathways. J Cell Sci. 2005;118:3061-71 pubmed
    ..Whereas the cis, medial and trans Golgi membranes redistributed to the ER, the trans Golgi network (TGN) collapsed back to a compact juxtanuclear position similar to that seen with brefeldin A (BFA) ..
  7. Derby M, Lieu Z, Brown D, Stow J, Goud B, Gleeson P. The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structure. Traffic. 2007;8:758-73 pubmed
  8. Wang Y, Tai G, Lu L, Johannes L, Hong W, Tang B. Trans-Golgi network syntaxin 10 functions distinctly from syntaxins 6 and 16. Mol Membr Biol. 2005;22:313-25 pubmed
  9. Hanada K, Kumagai K, Tomishige N, Kawano M. CERT and intracellular trafficking of ceramide. Biochim Biophys Acta. 2007;1771:644-53 pubmed

More Information

Publications62

  1. Valk E, Leung R, Kang H, Kaneko K, Rudd C, Schneider H. T cell receptor-interacting molecule acts as a chaperone to modulate surface expression of the CTLA-4 coreceptor. Immunity. 2006;25:807-21 pubmed
    ..study, we demonstrated that the adaptor TRIM (T cell receptor-interacting molecule) bound to CTLA-4 in the trans Golgi network (TGN) and promoted transport of CTLA-4 to the surface of T cells...
  2. Saint Pol A, Yélamos B, Amessou M, Mills I, Dugast M, Tenza D, et al. Clathrin adaptor epsinR is required for retrograde sorting on early endosomal membranes. Dev Cell. 2004;6:525-38 pubmed
    ..In conclusion, our work reveals the existence of clathrin-independent and -dependent transport steps in the retrograde route, and establishes a function for clathrin and epsinR at the endosome-TGN interface...
  3. Scott P, Bilodeau P, Zhdankina O, Winistorfer S, Hauglund M, Allaman M, et al. GGA proteins bind ubiquitin to facilitate sorting at the trans-Golgi network. Nat Cell Biol. 2004;6:252-9 pubmed
    ..Thus, GGA proteins fulfill the role of ubiquitin sorting receptors at the TGN...
  4. Mikhaylova M, Reddy P, Munsch T, Landgraf P, Suman S, Smalla K, et al. Calneurons provide a calcium threshold for trans-Golgi network to plasma membrane trafficking. Proc Natl Acad Sci U S A. 2009;106:9093-8 pubmed publisher
    ..The opposing roles of calneurons and NCS-1 provide a molecular switch to decode local calcium transients at the Golgi and impose a calcium threshold for PI-4Kbeta activity and vesicle trafficking...
  5. Yeaman C, Ayala M, Wright J, Bard F, Bossard C, Ang A, et al. Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network. Nat Cell Biol. 2004;6:106-12 pubmed
    ..PKD activity is required only for the transport of proteins containing basolateral sorting information, and seems to be cargo specific...
  6. Chidambaram S, Müllers N, Wiederhold K, Haucke V, von Mollard G. Specific interaction between SNAREs and epsin N-terminal homology (ENTH) domains of epsin-related proteins in trans-Golgi network to endosome transport. J Biol Chem. 2004;279:4175-9 pubmed
    ..These results point toward a novel function of the ENTH domain and a connection between proteins that function either in vesicle formation or in vesicle fusion...
  7. FOLSCH H, Pypaert M, Maday S, Pelletier L, Mellman I. The AP-1A and AP-1B clathrin adaptor complexes define biochemically and functionally distinct membrane domains. J Cell Biol. 2003;163:351-62 pubmed
    ..Thus, despite the similarity of the two AP-1 complexes, AP-1A and AP-1B exhibit great specificity for endosomal transport versus cell polarity...
  8. Schaub B, Berger B, Berger E, Rohrer J. Transition of galactosyltransferase 1 from trans-Golgi cisterna to the trans-Golgi network is signal mediated. Mol Biol Cell. 2006;17:5153-62 pubmed
    ..On the basis of these data, we suggest that cycling between the trans-Golgi cisterna and the trans-Golgi network of galT is signal mediated...
  9. D Angelo G, Polishchuk E, Di Tullio G, Santoro M, Di Campli A, Godi A, et al. Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide. Nature. 2007;449:62-7 pubmed
    ..Thus, by coupling the synthesis of glycosphingolipids with their export to the cell surface, FAPP2 emerges as crucial in determining the lipid identity and composition of the plasma membrane...
  10. Yoshino A, Bieler B, Harper D, Cowan D, Sutterwala S, Gay D, et al. A role for GRIP domain proteins and/or their ligands in structure and function of the trans Golgi network. J Cell Sci. 2003;116:4441-54 pubmed
    ..golgin-97 are members of a family of peripheral membrane proteins of unknown function that localize to the trans Golgi network (TGN) through a conserved C-terminal GRIP domain...
  11. Dettmer J, Hong Hermesdorf A, Stierhof Y, Schumacher K. Vacuolar H+-ATPase activity is required for endocytic and secretory trafficking in Arabidopsis. Plant Cell. 2006;18:715-30 pubmed
    ..Together, our results suggest the convergence of the early endocytic and secretory trafficking pathways in the TGN...
  12. Ishizaki R, Shin H, Iguchi Ariga S, Ariga H, Nakayama K. AMY-1 (associate of Myc-1) localization to the trans-Golgi network through interacting with BIG2, a guanine-nucleotide exchange factor for ADP-ribosylation factors. Genes Cells. 2006;11:949-59 pubmed
  13. Wang C, Hamamoto S, Orci L, Schekman R. Exomer: A coat complex for transport of select membrane proteins from the trans-Golgi network to the plasma membrane in yeast. J Cell Biol. 2006;174:973-83 pubmed
    ..Unlike other coats (e.g., coat protein complex I, II, and clathrin/adaptor protein complex), the exomer does not form buds or vesicles on liposomes...
  14. Traub L. Common principles in clathrin-mediated sorting at the Golgi and the plasma membrane. Biochim Biophys Acta. 2005;1744:415-37 pubmed
    ..This improved appreciation of the complex mechanisms governing clathrin-dependent sorting events reveals several common principles of clathrin operation at the Golgi and the plasma membrane...
  15. Natarajan P, Wang J, Hua Z, Graham T. Drs2p-coupled aminophospholipid translocase activity in yeast Golgi membranes and relationship to in vivo function. Proc Natl Acad Sci U S A. 2004;101:10614-9 pubmed
    ..Therefore, whereas NBD-PS is a preferred substrate for Drs2p in vitro, endogenous PS is not an obligatory substrate in vivo for the role Drs2p plays in protein transport...
  16. Godi A, Di Campli A, Konstantakopoulos A, Di Tullio G, Alessi D, Kular G, et al. FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. Nat Cell Biol. 2004;6:393-404 pubmed
    ..Moreover, overexpression of FAPP-PH impairs carrier fission. Therefore, FAPPs are essential components of a PtdIns(4)P- and ARF-regulated machinery that controls generation of constitutive post-Golgi carriers...
  17. Gleeson P, Lock J, Luke M, Stow J. Domains of the TGN: coats, tethers and G proteins. Traffic. 2004;5:315-26 pubmed
    ..Diversity within these protein families is highlighted and shown to be critical for the functionality of the trans-Golgi network, as a mediator of protein sorting and membrane transport, and for the maintenance of Golgi structure...
  18. Bai H, Doray B, Kornfeld S. GGA1 interacts with the adaptor protein AP-1 through a WNSF sequence in its hinge region. J Biol Chem. 2004;279:17411-7 pubmed
    ..These results suggest that the GGA1 WXXF-type and Rabaptin5 FXXPhi-type motifs bind to the same or highly overlapping sites in the AP-1 gamma-ear. This binding is modulated by residues adjacent to the core motifs...
  19. Wassmer T, Attar N, Harterink M, van Weering J, Traer C, Oakley J, et al. The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. Dev Cell. 2009;17:110-22 pubmed publisher
    ..These interactions describe fundamental steps in retromer-mediated transport and establish that the spatial organization of the retromer network is a critical element required for efficient retromer-mediated sorting...
  20. Wang J, Sun H, Macia E, Kirchhausen T, Watson H, Bonifacino J, et al. PI4P promotes the recruitment of the GGA adaptor proteins to the trans-Golgi network and regulates their recognition of the ubiquitin sorting signal. Mol Biol Cell. 2007;18:2646-55 pubmed
  21. Oztan A, Silvis M, Weisz O, Bradbury N, Hsu S, Goldenring J, et al. Exocyst requirement for endocytic traffic directed toward the apical and basolateral poles of polarized MDCK cells. Mol Biol Cell. 2007;18:3978-92 pubmed
  22. Hua W, Sheff D, Toomre D, Mellman I. Vectorial insertion of apical and basolateral membrane proteins in polarized epithelial cells revealed by quantitative 3D live cell imaging. J Cell Biol. 2006;172:1035-44 pubmed
  23. Cancino J, Torrealba C, Soza A, Yuseff M, Gravotta D, Henklein P, et al. Antibody to AP1B adaptor blocks biosynthetic and recycling routes of basolateral proteins at recycling endosomes. Mol Biol Cell. 2007;18:4872-84 pubmed
  24. Demmel L, Gravert M, Ercan E, Habermann B, MULLER REICHERT T, Kukhtina V, et al. The clathrin adaptor Gga2p is a phosphatidylinositol 4-phosphate effector at the Golgi exit. Mol Biol Cell. 2008;19:1991-2002 pubmed publisher
    ..These data provide an explanation for the TGN-specific membrane recruitment of Gga2p...
  25. Deborde S, Perret E, Gravotta D, Deora A, Salvarezza S, Schreiner R, et al. Clathrin is a key regulator of basolateral polarity. Nature. 2008;452:719-23 pubmed publisher
    ..Our results demonstrate a broad requirement for clathrin in basolateral protein trafficking in epithelial cells...
  26. FOLSCH H, Mattila P, Weisz O. Taking the scenic route: biosynthetic traffic to the plasma membrane in polarized epithelial cells. Traffic. 2009;10:972-81 pubmed publisher
    ..This review summarizes our current understanding of these routes and discusses open issues that remain to be clarified...
  27. Waguri S, Tomiyama Y, Ikeda H, Hida T, Sakai N, Taniike M, et al. The luminal domain participates in the endosomal trafficking of the cation-independent mannose 6-phosphate receptor. Exp Cell Res. 2006;312:4090-107 pubmed
  28. Pfeffer S. Multiple routes of protein transport from endosomes to the trans Golgi network. FEBS Lett. 2009;583:3811-6 pubmed publisher
    ..The identification of distinct molecular requirements for each of these pathways makes it clear that mammalian cells have evolved more complex targeting mechanisms and routes than previously anticipated...
  29. Jeffries T, Dove S, Michell R, Parker P. PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49. Mol Biol Cell. 2004;15:2652-63 pubmed
    ..We conclude that WIPI49 is a novel regulatory component of the endosomal and MPR pathway and that this role is dependent upon the PI-binding properties of its WD40 domain...
  30. Carlton J, Bujny M, Peter B, Oorschot V, Rutherford A, Arkell R, et al. Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport. J Cell Sci. 2005;118:4527-39 pubmed
    ..data suggest that although sorting nexin-2 may be a component of the retromer complex, its presence is not essential for the regulation of endosome-to-trans Golgi network retrieval of the cation-independent mannose 6-phosphate receptor.
  31. Turcotte S, Letellier J, Lippé R. Herpes simplex virus type 1 capsids transit by the trans-Golgi network, where viral glycoproteins accumulate independently of capsid egress. J Virol. 2005;79:8847-60 pubmed
    ..Moreover, this accumulation occurred independently of capsid egress. Surprisingly, capsids were often found immediately adjacent to the viral glycoproteins at the TGN...
  32. Nelson W, Rodriguez Boulan E. Unravelling protein sorting. Nat Cell Biol. 2004;6:282-4 pubmed
  33. Tai G, Lu L, Wang T, Tang B, Goud B, Johannes L, et al. Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network. Mol Biol Cell. 2004;15:4011-22 pubmed
    ..Further studies indicated that syntaxin 5 and syntaxin 16 exerted their role in EE/RE-TGN transport in an additive manner. The kinetics of inhibition exhibited by syntaxin 16 and syntaxin 5 antibodies is similar...
  34. Trautwein M, Schindler C, Gauss R, Dengjel J, Hartmann E, Spang A. Arf1p, Chs5p and the ChAPs are required for export of specialized cargo from the Golgi. EMBO J. 2006;25:943-54 pubmed
    ..In addition, they are all at least partially localized to the TGN in a Chs5p-dependent manner. Most importantly, several ChAPs can interact physically with Chs3p. We propose that the ChAPs facilitate export of cargo out of the Golgi...
  35. Salvarezza S, Deborde S, Schreiner R, Campagne F, Kessels M, Qualmann B, et al. LIM kinase 1 and cofilin regulate actin filament population required for dynamin-dependent apical carrier fission from the trans-Golgi network. Mol Biol Cell. 2009;20:438-51 pubmed publisher
  36. Rojas R, van Vlijmen T, Mardones G, Prabhu Y, Rojas A, Mohammed S, et al. Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7. J Cell Biol. 2008;183:513-26 pubmed publisher
    ..These findings demonstrate that Rab5 and Rab7 act in concert to regulate retromer recruitment to endosomes...
  37. Peden A, Oorschot V, Hesser B, Austin C, Scheller R, Klumperman J. Localization of the AP-3 adaptor complex defines a novel endosomal exit site for lysosomal membrane proteins. J Cell Biol. 2004;164:1065-76 pubmed
    ..Based on these data, we propose that AP-3 defines a novel pathway by which lysosomal membrane proteins are transported from tubular sorting endosomes to lysosomes. ..
  38. Lieu Z, Lock J, Hammond L, La Gruta N, Stow J, Gleeson P. A trans-Golgi network golgin is required for the regulated secretion of TNF in activated macrophages in vivo. Proc Natl Acad Sci U S A. 2008;105:3351-6 pubmed publisher
    ..Also, we have demonstrated a previously undescribed approach to control cytokine secretion by the specific silencing of trafficking machinery...
  39. Mari M, Bujny M, Zeuschner D, Geerts W, Griffith J, Petersen C, et al. SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors. Traffic. 2008;9:380-93 pubmed
    Mannose-6-phosphate receptors (MPRs) transport lysosomal hydrolases from the trans Golgi network (TGN) to endosomes...
  40. Lu L, Tai G, Hong W. Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-golgi network. Mol Biol Cell. 2004;15:4426-43 pubmed
    ..We suggest that Golgin-97 may function as a tethering molecule in endosome-to-TGN retrograde traffic. ..
  41. Ellis M, Miedel M, Guerriero C, Weisz O. ADP-ribosylation factor 1-independent protein sorting and export from the trans-Golgi network. J Biol Chem. 2004;279:52735-43 pubmed
    ..These data suggest that TGN sorting and export of influenza HA does not require classical adaptors involved in the formation of other classes of exocytic carriers and thus appears to proceed via a novel mechanism...
  42. Johnston H, Foote C, Santeford A, Nothwehr S. Golgi-to-late endosome trafficking of the yeast pheromone processing enzyme Ste13p is regulated by a phosphorylation site in its cytosolic domain. Mol Biol Cell. 2005;16:1456-68 pubmed
    ..These results indicate that S13 phosphorylation is required for TGN-to-PVC trafficking of A-ALP and imply that phosphorylation of S13 may regulate recognition of A-ALP by vesicular trafficking machinery...
  43. Wassmer T, Attar N, Bujny M, Oakley J, Traer C, Cullen P. A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer. J Cell Sci. 2007;120:45-54 pubmed
    ..SNX5 and SNX6 may therefore constitute functional equivalents of Vps17p in mammals...
  44. Bossard C, Bresson D, Polishchuk R, Malhotra V. Dimeric PKD regulates membrane fission to form transport carriers at the TGN. J Cell Biol. 2007;179:1123-31 pubmed
    ..These findings demonstrate that PKD regulates membrane fission and this activity is used to control the size of transport carriers, and to prevent uncontrolled vesiculation of TGN during protein transport...
  45. Feng Y, Jadhav A, Rodighiero C, Fujinaga Y, Kirchhausen T, Lencer W. Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells. EMBO Rep. 2004;5:596-601 pubmed
    ..We propose that even in the absence of Exo2 the glycolipid pathway that carries the toxin from plasma membrane into the ER bypasses the Golgi apparatus entirely...
  46. Sugimoto K, Uema M, Sagara H, Tanaka M, Sata T, Hashimoto Y, et al. Simultaneous tracking of capsid, tegument, and envelope protein localization in living cells infected with triply fluorescent herpes simplex virus 1. J Virol. 2008;82:5198-211 pubmed publisher
    ..This is the first real evidence for the assembly of all three types of herpesvirus proteins-capsid, tegument, and envelope membrane proteins-in TGN...
  47. He X, Li F, Chang W, Tang J. GGA proteins mediate the recycling pathway of memapsin 2 (BACE). J Biol Chem. 2005;280:11696-703 pubmed
    ..These observations suggest that GGA proteins function with the phosphorylated ACDL in the memapsin 2-recycling pathway from endosomes to trans-Golgi on the way back to the cell surface...
  48. Schuck S, Gerl M, Ang A, Manninen A, Keller P, Mellman I, et al. Rab10 is involved in basolateral transport in polarized Madin-Darby canine kidney cells. Traffic. 2007;8:47-60 pubmed
    ..These results indicate that Rab10 functions in trafficking from the Golgi at early stages of epithelial polarization, is involved in biosynthetic transport to the basolateral membrane and may co-operate with Rab8...
  49. Polishchuk R, Di Pentima A, Lippincott Schwartz J. Delivery of raft-associated, GPI-anchored proteins to the apical surface of polarized MDCK cells by a transcytotic pathway. Nat Cell Biol. 2004;6:297-307 pubmed
    ..Thus, apical sorting of these GPI-anchored proteins occurs at the plasma membrane, rather than at the TGN...
  50. Reddy J, Burguete A, Sridevi K, Ganley I, Nottingham R, Pfeffer S. A functional role for the GCC185 golgin in mannose 6-phosphate receptor recycling. Mol Biol Cell. 2006;17:4353-63 pubmed
    ..These data assign a specific pathway to an interesting, TGN-localized protein and suggest that GCC185 may participate in the docking of late endosome-derived, Rab9-bearing transport vesicles at the TGN...
  51. Ang A, FOLSCH H, Koivisto U, Pypaert M, Mellman I. The Rab8 GTPase selectively regulates AP-1B-dependent basolateral transport in polarized Madin-Darby canine kidney cells. J Cell Biol. 2003;163:339-50 pubmed
    ..However, expression of active Rab8 caused a selective dissociation of AP-1B complexes, reflecting the specificity of Rab8 for AP-1B-dependent transport...
  52. Bonifacino J, Hurley J. Retromer. Curr Opin Cell Biol. 2008;20:427-36 pubmed publisher
    ..Recent studies have implicated retromer in a broad range of physiological, developmental and pathological processes, underscoring the critical nature of retrograde transport mediated by this complex...
  53. Ghosh P, Griffith J, Geuze H, Kornfeld S. Mammalian GGAs act together to sort mannose 6-phosphate receptors. J Cell Biol. 2003;163:755-66 pubmed
    ..The morphology of the TGN was also altered. These findings indicate that the three mammalian GGAs cooperate to sort cargo and are required for maintenance of TGN structure...