vacuoles

Summary

Summary: Any spaces or cavities within a cell. They may function in digestion, storage, secretion, or excretion.

Top Publications

  1. Meunier E, Dick M, Dreier R, Schürmann N, Kenzelmann Broz D, Warming S, et al. Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases. Nature. 2014;509:366-70 pubmed publisher
    ..These results indicate that host-mediated lysis of pathogen-containing vacuoles is an essential immune function and is necessary for efficient recognition of pathogens by inflammasome complexes ..
  2. Perdrix A, Travers A, Clatot F, Sibert L, Mitchell V, Jumeau F, et al. Modification of chromosomal architecture in human spermatozoa with large vacuoles. Andrology. 2013;1:57-66 pubmed publisher
    ..Spermatozoa with large vacuoles, described using motile sperm organelle morphology organization (MSOME), are associated with nuclear alterations, ..
  3. Gatimel N, Léandri R, Foliguet B, Bujan L, Parinaud J. Sperm cephalic vacuoles: new arguments for their non acrosomal origin in two cases of total globozoospermia. Andrology. 2013;1:52-6 pubmed publisher
    To add new arguments concerning the origin of the sperm-head vacuoles observed under high magnification with interference contrast microscopy, we carried out in two patients with total globozoospermia confirmed using transmission electron ..
  4. Cabrera M, Arlt H, Epp N, Lachmann J, Griffith J, Perz A, et al. Functional separation of endosomal fusion factors and the class C core vacuole/endosome tethering (CORVET) complex in endosome biogenesis. J Biol Chem. 2013;288:5166-75 pubmed publisher
    ..Overall, our study reveals a unique role of CORVET in the sorting of biosynthetic cargo to the vacuole/lysosome...
  5. Sriskanthadevan S, Brar S, Manoharan K, Siu C. Ca(2+) -calmodulin interacts with DdCAD-1 and promotes DdCAD-1 transport by contractile vacuoles in Dictyostelium cells. FEBS J. 2013;280:1795-806 pubmed publisher
    ..at the onset of development as a soluble protein and then transported to the plasma membrane by contractile vacuoles. Calmodulin associates with contractile vacuoles in a Ca(2+) -dependent manner, and co-localizes with DdCAD-1 on ..
  6. Zhou L, Li S, Feng Q, Zhang Y, Zhao X, Zeng Y, et al. Protein S-ACYL Transferase10 is critical for development and salt tolerance in Arabidopsis. Plant Cell. 2013;25:1093-107 pubmed publisher
    ..We propose that PAT10-mediated palmitoylation is critical for vacuolar function by regulating membrane association or the activities of tonoplast proteins...
  7. Haldar A, Saka H, Piro A, Dunn J, Henry S, Taylor G, et al. IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins. PLoS Pathog. 2013;9:e1003414 pubmed publisher
    ..IRGs and GBPs stably associate with pathogen-containing vacuoles (PVs) and elicit immune pathways directed at the targeted vacuoles...
  8. Perdrix A, Rives N. Motile sperm organelle morphology examination (MSOME) and sperm head vacuoles: state of the art in 2013. Hum Reprod Update. 2013;19:527-41 pubmed publisher
    ..introducing the motile sperm organelle morphology examination (MSOME), many questions remained about sperm vacuoles: frequency, size, localization, mode of occurrence, biological significance and impact on male fertility ..
  9. Myeni S, Child R, Ng T, Kupko J, Wehrly T, Porcella S, et al. Brucella modulates secretory trafficking via multiple type IV secretion effector proteins. PLoS Pathog. 2013;9:e1003556 pubmed publisher
    ..Taken together, these findings demonstrate that Brucella modulates secretory trafficking via multiple T4SS effector proteins that likely act coordinately to promote Brucella pathogenesis...

More Information

Publications62

  1. Francisco R, Regalado A, Ageorges A, Burla B, Bassin B, Eisenach C, et al. ABCC1, an ATP binding cassette protein from grape berry, transports anthocyanidin 3-O-Glucosides. Plant Cell. 2013;25:1840-54 pubmed publisher
    ..In conclusion, we provide evidence that ABCC1 acts as an anthocyanin transporter that depends on GSH without the formation of an anthocyanin-GSH conjugate...
  2. Neyer A, Vanderzwalmen P, Bach M, Stecher A, Spitzer D, Zech N. Sperm head vacuoles are not affected by in-vitro conditions, as analysed by a system of sperm-microcapture channels. Reprod Biomed Online. 2013;26:368-77 pubmed publisher
    ..morphology examination, there has been increasing recognition of the fact that the presence of large nuclear vacuoles might have deleterious effects on embryo development...
  3. O Connor T, Boyd D, Dorer M, Isberg R. Aggravating genetic interactions allow a solution to redundancy in a bacterial pathogen. Science. 2012;338:1440-4 pubmed publisher
    ..This strategy is broadly applicable, allowing the dissection of any interface between two organisms involving numerous interactions...
  4. Hoshi A, Yamamoto T, Kikuchi S, Soeda T, Shimizu K, Ugawa Y. Aquaporin-4 expression in distal myopathy with rimmed vacuoles. BMC Neurol. 2012;12:22 pubmed publisher
    Distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy is clinically characterized by the early involvement of distal leg muscles. The striking pathological features of the myopathy are muscle fibers with rimmed vacuoles...
  5. Hritonenko V, Evans D, Fleiszig S. Translocon-independent intracellular replication by Pseudomonas aeruginosa requires the ADP-ribosylation domain of ExoS. Microbes Infect. 2012;14:1366-73 pubmed publisher
    ..All translocon mutants, irrespective of effectors expressed, localized to intracellular vacuoles. Translocon-effector null mutants and translocon-exoS mutants showed defective intracellular replication...
  6. Hamon M, Ribet D, Stavru F, Cossart P. Listeriolysin O: the Swiss army knife of Listeria. Trends Microbiol. 2012;20:360-8 pubmed publisher
    ..These latest findings along with their impact on the infectious process will be discussed...
  7. Friedrich N, Hagedorn M, Soldati Favre D, Soldati T. Prison break: pathogens' strategies to egress from host cells. Microbiol Mol Biol Rev. 2012;76:707-20 pubmed publisher
    ..This review compares egress strategies of bacteria, pathogenic yeast, and kinetoplastid and apicomplexan parasites. Emphasis is given to recent advances in the biology of egress in mycobacteria and apicomplexans...
  8. Lachmann J, Barr F, Ungermann C. The Msb3/Gyp3 GAP controls the activity of the Rab GTPases Vps21 and Ypt7 at endosomes and vacuoles. Mol Biol Cell. 2012;23:2516-26 pubmed publisher
    ..complex with Vps21, has the highest activity of all recombinant GAPs for Vps21 in vitro, and is found at vacuoles despite its predominant localization to bud tips and bud necks at the plasma membrane...
  9. Curtis S, Jones C, Garrod A, Hulme C, Heazell A. Identification of autophagic vacuoles and regulators of autophagy in villous trophoblast from normal term pregnancies and in fetal growth restriction. J Matern Fetal Neonatal Med. 2013;26:339-46 pubmed publisher
    ..We conclude that autophagy in human term placenta may be involved in the placental dysfunction present in FGR...
  10. Martinoia E, Meyer S, De Angeli A, Nagy R. Vacuolar transporters in their physiological context. Annu Rev Plant Biol. 2012;63:183-213 pubmed publisher
    b>Vacuoles in vegetative tissues allow the plant surface to expand by accumulating energetically cheap inorganic osmolytes, and thereby optimize the plant for absorption of sunlight and production of energy by photosynthesis...
  11. Essid M, Gopaldass N, Yoshida K, Merrifield C, Soldati T. Rab8a regulates the exocyst-mediated kiss-and-run discharge of the Dictyostelium contractile vacuole. Mol Biol Cell. 2012;23:1267-82 pubmed publisher
    ..allows fusion but blocks vacuole detachment from the plasma membrane, inducing complete fragmentation of tethered vacuoles. An indistinguishable phenotype is generated in cells lacking LvsA, implicating this protein in postfusion ..
  12. Dasari P, Reiss K, Lingelbach K, Baumeister S, Lucius R, Udomsangpetch R, et al. Digestive vacuoles of Plasmodium falciparum are selectively phagocytosed by and impair killing function of polymorphonuclear leukocytes. Blood. 2011;118:4946-56 pubmed publisher
    ..Systemic overloading of PMNs with DVs may contribute to the enhanced susceptibility of patients with severe malaria toward invasive bacterial infections...
  13. Florey O, Kim S, Sandoval C, Haynes C, Overholtzer M. Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes. Nat Cell Biol. 2011;13:1335-43 pubmed publisher
    ..Here we report the modification of single-membrane vacuoles in cells by autophagy proteins...
  14. Huang B, Ojogun N, Ragland S, Carlyon J. Monoubiquitinated proteins decorate the Anaplasma phagocytophilum-occupied vacuolar membrane. FEMS Immunol Med Microbiol. 2012;64:32-41 pubmed publisher
    ..phagocytophilum remodels the composition of its host cell-derived vacuolar membrane and present the first example of a Rickettsiales pathogen co-opting ubiquitin during intracellular residence...
  15. Herberth S, Shahriari M, Bruderek M, Hessner F, Müller B, Hulskamp M, et al. Artificial ubiquitylation is sufficient for sorting of a plasma membrane ATPase to the vacuolar lumen of Arabidopsis cells. Planta. 2012;236:63-77 pubmed publisher
    ..Our results suggest that ubiquitin can in principle act as vacuolar sorting signal in plants...
  16. Lin M, Li S, Kane P, Höfken T. Regulation of vacuolar H+-ATPase activity by the Cdc42 effector Ste20 in Saccharomyces cerevisiae. Eukaryot Cell. 2012;11:442-51 pubmed publisher
    ..We propose that during filamentous growth, Ste20 stimulates V-ATPase activity. This would sustain nutrient mobilization from vacuolar stores, which is beneficial for filamentous growth...
  17. Dumoux M, Clare D, Saibil H, Hayward R. Chlamydiae assemble a pathogen synapse to hijack the host endoplasmic reticulum. Traffic. 2012;13:1612-27 pubmed publisher
    ..Our data show a supramolecular assembly involved in pathogen hijack of a key host organelle...
  18. Montjean D, Belloc S, Benkhalifa M, Dalleac A, Menezo Y. Sperm vacuoles are linked to capacitation and acrosomal status. Hum Reprod. 2012;27:2927-32 pubmed publisher
    Is the presence of nuclear vacuoles really a negative parameter?
  19. Ding Y, Wang J, Wang J, Stierhof Y, Robinson D, Jiang L. Unconventional protein secretion. Trends Plant Sci. 2012;17:606-15 pubmed publisher
    ..Here, we review the evidence for UPS in plants especially in regard to the recently discovered EXPO (exocyst-positive-organelle)...
  20. Li F, Vierstra R. Autophagy: a multifaceted intracellular system for bulk and selective recycling. Trends Plant Sci. 2012;17:526-37 pubmed publisher
  21. Bandmann V, Homann U. Clathrin-independent endocytosis contributes to uptake of glucose into BY-2 protoplasts. Plant J. 2012;70:578-84 pubmed publisher
    ..These data demonstrate that clathrin-independent endocytosis does occur in plant cells. This pathway may represent a common mechanism for the uptake of external nutrients...
  22. Starr T, Child R, Wehrly T, Hansen B, Hwang S, López Otin C, et al. Selective subversion of autophagy complexes facilitates completion of the Brucella intracellular cycle. Cell Host Microbe. 2012;11:33-45 pubmed publisher
  23. Ehsani S, Santos J, Rodrigues C, Henriques R, Audry L, Zimmer C, et al. Hierarchies of host factor dynamics at the entry site of Shigella flexneri during host cell invasion. Infect Immun. 2012;80:2548-57 pubmed publisher
    ..Together, our studies show that bacterial entry into host cells follows precise kinetics and that this time course can be targeted by the pathogen...
  24. Creasey E, Isberg R. The protein SdhA maintains the integrity of the Legionella-containing vacuole. Proc Natl Acad Sci U S A. 2012;109:3481-6 pubmed publisher
    ..This vacuolar niche affords the bacterium protection from cytosolic host factors that degrade bacteria and initiate immune responses...
  25. Momma K, Noguchi S, Malicdan M, Hayashi Y, Minami N, Kamakura K, et al. Rimmed vacuoles in Becker muscular dystrophy have similar features with inclusion myopathies. PLoS ONE. 2012;7:e52002 pubmed publisher
    Rimmed vacuoles in myofibers are thought to be due to the accumulation of autophagic vacuoles, and can be characteristic in certain myopathies with protein inclusions in myofibers...
  26. Munoz A, Marcos J, Read N. Concentration-dependent mechanisms of cell penetration and killing by the de novo designed antifungal hexapeptide PAF26. Mol Microbiol. 2012;85:89-106 pubmed publisher
    ..0-5 µM). At these concentrations, PAF26 initially accumulated in vacuoles that expanded, and then was actively transported into the cytoplasm, which coincided with cell death...
  27. Virreira Winter S, Niedelman W, Jensen K, Rosowski E, Julien L, Spooner E, et al. Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it. PLoS ONE. 2011;6:e24434 pubmed publisher
    ..gondii in animals may rely in part on recognition by GBPs. However, phagosomes or vacuoles containing Trypanosoma cruzi did not recruit mGBP1...
  28. Petroi D, Popova B, Taheri Talesh N, Irniger S, Shahpasandzadeh H, Zweckstetter M, et al. Aggregate clearance of ?-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome. J Biol Chem. 2012;287:27567-79 pubmed publisher
    ..This contributes to the understanding of how cells can cope with toxic and/or aggregated proteins and may ultimately enable the development of novel strategies for therapeutic intervention...
  29. Barragán V, Leidi E, Andrés Z, Rubio L, De Luca A, Fernandez J, et al. Ion exchangers NHX1 and NHX2 mediate active potassium uptake into vacuoles to regulate cell turgor and stomatal function in Arabidopsis. Plant Cell. 2012;24:1127-42 pubmed publisher
    ..Together, these results show that tonoplast-localized NHX proteins are essential for active K(+) uptake at the tonoplast, for turgor regulation, and for stomatal function...
  30. Canton J, Ndjamen B, Hatsuzawa K, Kima P. Disruption of the fusion of Leishmania parasitophorous vacuoles with ER vesicles results in the control of the infection. Cell Microbiol. 2012;14:937-48 pubmed publisher
    Parasitophorous vacuoles (PV) that harbour Leishmania parasites acquire some characteristics from fusion with host cell vesicles. Recent studies have shown that PVs acquire and display resident endoplasmic reticulum (ER) molecules...
  31. Real F, Mortara R. The diverse and dynamic nature of Leishmania parasitophorous vacuoles studied by multidimensional imaging. PLoS Negl Trop Dis. 2012;6:e1518 pubmed publisher
    An important area in the cell biology of intracellular parasitism is the customization of parasitophorous vacuoles (PVs) by prokaryotic or eukaryotic intracellular microorganisms...
  32. Rivera Serrano E, Rodriguez Welsh M, Hicks G, Rojas Pierce M. A small molecule inhibitor partitions two distinct pathways for trafficking of tonoplast intrinsic proteins in Arabidopsis. PLoS ONE. 2012;7:e44735 pubmed publisher
    ..Our results indicate that the vacuolar targeting of PIN2 and the BFA-insensitive pathway for tonoplast proteins may be mediated in part by common mechanisms...
  33. Batistic O. Genomics and localization of the Arabidopsis DHHC-cysteine-rich domain S-acyltransferase protein family. Plant Physiol. 2012;160:1597-612 pubmed publisher
    ..This large concentration of plant PAT activity to the plasma membrane suggests that the plant cellular S-acylation machinery is functionally different compared with that of yeast (Saccharomyces cerevisiae) and mammalians...
  34. Hardiman C, McDonough J, Newton H, Roy C. The role of Rab GTPases in the transport of vacuoles containing Legionella pneumophila and Coxiella burnetii. Biochem Soc Trans. 2012;40:1353-9 pubmed publisher
    ..present review, we cover how these bacterial species, which utilize divergent strategies to establish replicative vacuoles, use translocated proteins to manipulate host Rabs, as well as exploring which Rabs are implicated in vacuolar ..
  35. Vera I, Beatty W, Sinnis P, Kim K. Plasmodium protease ROM1 is important for proper formation of the parasitophorous vacuole. PLoS Pathog. 2011;7:e1002197 pubmed publisher
    ..We propose a novel function for PyROM1 as a protease that promotes proper PV modification to allow parasite development and replication in a suitable environment within the mammalian host...
  36. Ghigo E, Colombo M, Heinzen R. The Coxiella burnetii parasitophorous vacuole. Adv Exp Med Biol. 2012;984:141-69 pubmed publisher
    ..burnetii lipopolysaccharide phase variants in human mononuclear phagocytes...
  37. Beare P, Gilk S, Larson C, Hill J, Stead C, Omsland A, et al. Dot/Icm type IVB secretion system requirements for Coxiella burnetii growth in human macrophages. MBio. 2011;2:e00175-11 pubmed publisher
  38. Scheuring D, Viotti C, Krüger F, Künzl F, Sturm S, Bubeck J, et al. Multivesicular bodies mature from the trans-Golgi network/early endosome in Arabidopsis. Plant Cell. 2011;23:3463-81 pubmed publisher
    ..Here, we present evidence that post-TGN transport toward lytic vacuoles occurs independently of clathrin and that MVBs/LEs are derived from the TGN/EE through maturation...
  39. Strasser B, Iwaszkiewicz J, Michielin O, Mayer A. The V-ATPase proteolipid cylinder promotes the lipid-mixing stage of SNARE-dependent fusion of yeast vacuoles. EMBO J. 2011;30:4126-41 pubmed publisher
    ..We propose that a SNARE-dependent conformational change in V(0) proteolipids might stimulate fusion by creating a hydrophobic crevice that promotes lipid reorientation and formation of a lipidic fusion pore...
  40. Zucchi P, Zick M. Membrane fusion catalyzed by a Rab, SNAREs, and SNARE chaperones is accompanied by enhanced permeability to small molecules and by lysis. Mol Biol Cell. 2011;22:4635-46 pubmed publisher
  41. Codogno P, Mehrpour M, Proikas Cezanne T. Canonical and non-canonical autophagy: variations on a common theme of self-eating?. Nat Rev Mol Cell Biol. 2011;13:7-12 pubmed publisher
    ..Such alternatives to the evolutionarily conserved scheme might provide additional therapeutic opportunities...
  42. Stroupe C. The yeast vacuolar Rab GTPase Ypt7p has an activity beyond membrane recruitment of the homotypic fusion and protein sorting-Class C Vps complex. Biochem J. 2012;443:205-11 pubmed publisher
    ..lipid mixing of reconstituted proteoliposomes made using lipid mixtures that mimic the composition of yeast vacuoles. This lipid mixing required SNARE {SNAP [soluble NSF (N-ethylmaleimide-sensitive factor)-attachment protein] ..
  43. Cai Y, Zhuang X, Wang J, Wang H, Lam S, Gao C, et al. Vacuolar degradation of two integral plasma membrane proteins, AtLRR84A and OsSCAMP1, is cargo ubiquitination-independent and prevacuolar compartment-mediated in plant cells. Traffic. 2012;13:1023-40 pubmed publisher
    ..Thus, cargo ubiquitination-independent and PVC-mediated degradation of PM proteins in the vacuole is functionally operated in plant cells...
  44. Batistic O, Rehers M, Akerman A, Schlücking K, Steinhorst L, Yalovsky S, et al. S-acylation-dependent association of the calcium sensor CBL2 with the vacuolar membrane is essential for proper abscisic acid responses. Cell Res. 2012;22:1155-68 pubmed publisher
    ..These findings define an S-acylation-dependent vacuolar membrane targeting pathway for proteins and uncover a crucial role of vacuolar calcium sensors in ABA responses...
  45. Leitner J, Petrasek J, Tomanov K, Retzer K, Parezová M, Korbei B, et al. Lysine63-linked ubiquitylation of PIN2 auxin carrier protein governs hormonally controlled adaptation of Arabidopsis root growth. Proc Natl Acad Sci U S A. 2012;109:8322-7 pubmed publisher
    ..Collectively, our results establish lysine(63)-linked PM cargo ubiquitylation as a regulator of polar auxin transport and adaptive growth responses in higher plants...
  46. Kim C, Meskauskiene R, Zhang S, Lee K, Lakshmanan Ashok M, Blajecka K, et al. Chloroplasts of Arabidopsis are the source and a primary target of a plant-specific programmed cell death signaling pathway. Plant Cell. 2012;24:3026-39 pubmed publisher
    ..Our findings support an as yet unreported signaling role of (1)O(2) in the wild type exposed to mild light stress that invokes photoinhibition of photosystem II without causing photooxidative damage of the plant...
  47. Bröcker C, Kuhlee A, Gatsogiannis C, Balderhaar H, Hönscher C, Engelbrecht Vandré S, et al. Molecular architecture of the multisubunit homotypic fusion and vacuole protein sorting (HOPS) tethering complex. Proc Natl Acad Sci U S A. 2012;109:1991-6 pubmed publisher
    ..Vps11 and Vps18 connect head and tail. Our data suggest that HOPS bridges Ypt7-positive membranes and chaperones SNAREs at fusion sites...
  48. Bottanelli F, Gershlick D, Denecke J. Evidence for sequential action of Rab5 and Rab7 GTPases in prevacuolar organelle partitioning. Traffic. 2012;13:338-54 pubmed publisher
    ..A model describing the sequential action of Rab5 and Rab7 GTPases is presented in the light of the current observations...
  49. Florey O, Overholtzer M. Autophagy proteins in macroendocytic engulfment. Trends Cell Biol. 2012;22:374-80 pubmed publisher
    ..This review discusses the biological systems in which autophagy proteins have been found to regulate lysosome fusion to non-autophagic membranes...
  50. Schneider S, Hulpke S, Schulz A, Yaron I, Holl J, Imlau A, et al. Vacuoles release sucrose via tonoplast-localised SUC4-type transporters. Plant Biol (Stuttg). 2012;14:325-36 pubmed publisher
    ..1 mutants and AtSUC4 overexpressing (AtSUC4-OX) plants, and functional comparisons of Atsuc4.1 and AtSUC4-OX vacuoles. Our data show that SUC4-type sucrose transporters from different plant families (Brassicaceae, Cucurbitaceae and ..
  51. Abdelhalim M, Jarrar B. Gold nanoparticles induced cloudy swelling to hydropic degeneration, cytoplasmic hyaline vacuolation, polymorphism, binucleation, karyopyknosis, karyolysis, karyorrhexis and necrosis in the liver. Lipids Health Dis. 2011;10:166 pubmed publisher
  52. Stepinski D. Immunofluorescent localization of ubiquitin and proteasomes in nucleolar vacuoles of soybean root meristematic cells. Eur J Histochem. 2012;56:e13 pubmed publisher
    ..In fact, those signals were present exclusively in nucleolar vacuoles. No signals were observed in the nucleolar territory out of the nucleolar vacuoles or in the nucleoli without ..
  53. Komiya A, Watanabe A, Kawauchi Y, Fuse H. Sperm with large nuclear vacuoles and semen quality in the evaluation of male infertility. Syst Biol Reprod Med. 2013;59:13-20 pubmed publisher
    This study compared the sperm nuclear vacuoles and semen quality in the evaluation of male infertility...