Summary: Endosomes containing intraluminal vesicles which are formed by the inward budding of the endosome membrane. Multivesicular bodies (MVBs) may fuse with other organelles such as LYSOSOMES or fuse back with the PLASMA MEMBRANE releasing their contents by EXOCYTOSIS. The MVB intraluminal vesicles released into the extracellular environment are known as EXOSOMES.
Traub L. The reverse logic of multivesicular endosomes. EMBO Rep. 2010;11:79-81 pubmed publisher
Henne W, Stenmark H, Emr S. Molecular mechanisms of the membrane sculpting ESCRT pathway. Cold Spring Harb Perspect Biol. 2013;5: pubmed publisher
..Mechanistic comparisons of ESCRT-III function in MVB morphogenesis and cytokinesis suggest common mechanisms in membrane remodeling. ..
González A, Muñoz V, Cavieres V, Bustamante H, Cornejo V, Januário Y, et al
. Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway. FASEB J. 2017;31:2446-2459 pubmed publisher
..daSilva, L. L., Rojas-Fernández, A., Hay, R. T., Mardones, G. A., Burgos, P. V. Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway. ..
Gorur A, Yuan L, Kenny S, Baba S, Xu K, Schekman R. COPII-coated membranes function as transport carriers of intracellular procollagen I. J Cell Biol. 2017;216:1745-1759 pubmed publisher
..This process requires COPII proteins and the GTPase activity of the COPII subunit SAR1. We conclude that large COPII vesicles are bona fide carriers of PC1. ..
Yau R, Wong S, Weisman L. Spatial regulation of organelle release from myosin V transport by p21-activated kinases. J Cell Biol. 2017;216:1557-1566 pubmed publisher
..Our study reveals a critical step in the spatial regulation of myosin V-dependent organelle transport and may reveal common mechanisms for how molecular motors accurately deposit cargoes at the correct locations. ..
Buono R, Leier A, Paez Valencia J, Pennington J, Goodman K, Miller N, et al
. ESCRT-mediated vesicle concatenation in plant endosomes. J Cell Biol. 2017;216:2167-2177 pubmed publisher
..Consistent with a potential role as a diffusion barrier, we find that the ESCRT-III protein SNF7 remains associated with ILVs and is delivered to the vacuole for degradation. ..
Kobuna H, Inoue T, Shibata M, Gengyo Ando K, Yamamoto A, Mitani S, et al
. Multivesicular body formation requires OSBP-related proteins and cholesterol. PLoS Genet. 2010;6: pubmed publisher
..of ORPs in Caenorhabditis elegans, we show that ORPs are required for the formation and function of multivesicular bodies (MVBs)...
Zhao G, Zhang P, Gong J, Zhang X, Wang P, Yin M, et al
. Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4. Nat Med. 2017;23:742-752 pubmed publisher
..Taken together, these findings could lead to the development of promising strategies to treat NASH by targeting MVB regulators to properly orchestrate the lysosome-mediated protein degradation of key mediators of the disease. ..
Trajkovic K, Jeong H, Krainc D. Mutant Huntingtin Is Secreted via a Late Endosomal/Lysosomal Unconventional Secretory Pathway. J Neurosci. 2017;37:9000-9012 pubmed publisher
..Understanding and manipulating the secretion of mHtt is important because of its potentially harmful propagation in the brain. ..