coated vesicles

Summary

Summary: Vesicles formed when cell-membrane coated pits (COATED PITS, CELL-MEMBRANE) invaginate and pinch off. The outer surface of these vesicles are covered with a lattice-like network of coat proteins, such as CLATHRIN, coat protein complex proteins, or CAVEOLINS.

Top Publications

  1. Paul M, Frigerio L. Coated vesicles in plant cells. Semin Cell Dev Biol. 2007;18:471-8 pubmed
    b>Coated vesicles represent vital transport intermediates in all eukaryotic cells...
  2. Schekman R, Orci L. Coat proteins and vesicle budding. Science. 1996;271:1526-33 pubmed
    ..Secretion, which has been viewed as a default pathway, may require sorting and packaging signals on transported molecules to ensure their rapid delivery to the cell surface...
  3. Orci L, Stamnes M, Ravazzola M, Amherdt M, Perrelet A, Sollner T, et al. Bidirectional transport by distinct populations of COPI-coated vesicles. Cell. 1997;90:335-49 pubmed
    ..proinsulin and VSV G protein) and retrograde-directed (the KDEL receptor) cargo are present in COPI-coated vesicles budding from every level of the Golgi stack in whole cells; however, they comprise two distinct populations ..
  4. Devos D, Dokudovskaya S, Alber F, Williams R, Chait B, Sali A, et al. Components of coated vesicles and nuclear pore complexes share a common molecular architecture. PLoS Biol. 2004;2:e380 pubmed
    ..These similarities suggest a common evolutionary origin for nuclear pore complexes and coated vesicles in an early membrane-curving module that led to the formation of the internal membrane systems in modern ..
  5. Marsh M, McMahon H. The structural era of endocytosis. Science. 1999;285:215-20 pubmed
    ..because of (i) the identification of an array of molecules that orchestrate the assembly of clathrin-coated vesicles and the selection of the vesicle cargo and (ii) the resolution of structures for a number of these proteins...
  6. Bonifacino J, Lippincott Schwartz J. Coat proteins: shaping membrane transport. Nat Rev Mol Cell Biol. 2003;4:409-14 pubmed
    ..by concentrating macromolecules into specialized membrane patches and then deforming these patches into small coated vesicles. Recent findings indicate that coat proteins might also participate in the differentiation of membrane ..
  7. Sönnichsen B, Lowe M, Levine T, Jämsä E, Dirac Svejstrup B, Warren G. A role for giantin in docking COPI vesicles to Golgi membranes. J Cell Biol. 1998;140:1013-21 pubmed
    ..Together these results suggest that COPI vesicles are docked by giantin on the COPI vesicles and GM130 on Golgi membranes with p115 providing a bridge...
  8. Shaywitz D, Espenshade P, Gimeno R, Kaiser C. COPII subunit interactions in the assembly of the vesicle coat. J Biol Chem. 1997;272:25413-6 pubmed
    ..We propose that Sec16p organizes the assembly of a coat that is stabilized both by the interaction of Sec31p with Sec23p and Sec24p and by the interaction of these three components with Sec16p...
  9. Spang A, Schekman R. Reconstitution of retrograde transport from the Golgi to the ER in vitro. J Cell Biol. 1998;143:589-99 pubmed
    ..Putative retrograde carriers (COPI vesicles) generated from Golgi-enriched membranes contain v-SNAREs as well as Emp47p as cargo...

More Information

Publications62

  1. Gaynor E, Emr S. COPI-independent anterograde transport: cargo-selective ER to Golgi protein transport in yeast COPI mutants. J Cell Biol. 1997;136:789-802 pubmed
  2. Schledzewski K, Brinkmann H, Mendel R. Phylogenetic analysis of components of the eukaryotic vesicle transport system reveals a common origin of adaptor protein complexes 1, 2, and 3 and the F subcomplex of the coatomer COPI. J Mol Evol. 1999;48:770-8 pubmed
    ..The situation encountered today is the result of successive rounds of coordinated gene duplications of both the large and the small/medium subunits, with F-COPI being the first that separated from the ancestral pre-F-COPI...
  3. Simon J, Morimoto T, Bankaitis V, Gottlieb T, Ivanov I, Adesnik M, et al. An essential role for the phosphatidylinositol transfer protein in the scission of coatomer-coated vesicles from the trans-Golgi network. Proc Natl Acad Sci U S A. 1998;95:11181-6 pubmed
    ..buds, PITP induces local changes in the organization of the lipid bilayer, possibly involving PI metabolites, that triggers the fusion of the ectoplasmic faces of the Golgi membrane necessary for the scission of COPI-coated vesicles.
  4. de Vries L, Elenko E, McCaffery J, Fischer T, Hubler L, McQuistan T, et al. RGS-GAIP, a GTPase-activating protein for Galphai heterotrimeric G proteins, is located on clathrin-coated vesicles. Mol Biol Cell. 1998;9:1123-34 pubmed
    ..The presence of GAIP on CCVs suggests a model whereby a GAP is separated in space from its target G protein with the two coming into contact at the time of vesicle fusion...
  5. Jekely G, Arendt D. Evolution of intraflagellar transport from coated vesicles and autogenous origin of the eukaryotic cilium. Bioessays. 2006;28:191-8 pubmed
    ..Based on the homology of IFT complex proteins to components of coat protein I (COPI) and clathrin-coated vesicles, we propose that the non- vesicular, membrane-bound IFT evolved as a specialised form of coated vesicle ..
  6. Ungewickell E, Ungewickell H, Holstein S, Lindner R, Prasad K, Barouch W, et al. Role of auxilin in uncoating clathrin-coated vesicles. Nature. 1995;378:632-5 pubmed
    Clathrin-coated vesicles transport selected integral membrane proteins from the cell surface and the trans-Golgi network to the endosomal system. Before fusing with their target the vesicles must be stripped of their coats...
  7. Rothman J. Mechanisms of intracellular protein transport. Nature. 1994;372:55-63 pubmed
    ..Both vesicles and their acceptor membranes carry targeting proteins which interact specifically to initiate docking. A general apparatus then assembles at the docking site and fuses the vesicle with its target...
  8. Helms J, Helms Brons D, Brugger B, Gkantiragas I, Eberle H, Nickel W, et al. A putative heterotrimeric G protein inhibits the fusion of COPI-coated vesicles. Segregation of heterotrimeric G proteins from COPI-coated vesicles. J Biol Chem. 1998;273:15203-8 pubmed
    ..Identification of the proteins that interact with the heterotrimeric G proteins in the Golgi-derived detergent-insoluble complex might help to reveal the regulation of protein secretion mediated by heterotrimeric G proteins...
  9. Pley U, Hill B, Alibert C, Brodsky F, Parham P. The interaction of calmodulin with clathrin-coated vesicles, triskelions, and light chains. Localization of a binding site. J Biol Chem. 1995;270:2395-402 pubmed
    The binding of clathrin-coated vesicles, clathrin triskelions, and free clathrin light chains to calmodulin-Sepharose was compared...
  10. Spang A, Matsuoka K, Hamamoto S, Schekman R, Orci L. Coatomer, Arf1p, and nucleotide are required to bud coat protein complex I-coated vesicles from large synthetic liposomes. Proc Natl Acad Sci U S A. 1998;95:11199-204 pubmed
    Synthetic coat protein complex I (COPI)-coated vesicles form spontaneously from large ( approximately 300 nm in diameter), chemically defined liposomes incubated with coatomer, Arf1p, and guanosine 5'-[gamma-thio]triphosphate...
  11. Pepperkok R, Whitney J, Gomez M, Kreis T. COPI vesicles accumulating in the presence of a GTP restricted arf1 mutant are depleted of anterograde and retrograde cargo. J Cell Sci. 2000;113 ( Pt 1):135-44 pubmed
    ..of a GTP restricted mutant of the small GTPase arf1 (arf1[Q71L]) leads to the rapid accumulation of COPI coated vesicles and buds in living cells...
  12. Robinson M. Adaptable adaptors for coated vesicles. Trends Cell Biol. 2004;14:167-74 pubmed
    Adaptors select cargo for inclusion into coated vesicles in the late secretory and endocytic pathways...
  13. Schwartz J, Li G, Yang Q, Suri V, Ross J, Alexander E. Role of SNAREs and H+-ATPase in the targeting of proton pump-coated vesicles to collecting duct cell apical membrane. Kidney Int. 2007;72:1310-5 pubmed
    ..N-ethylmaleimide-sensitive factor attachment proteins) may be involved in the targeting of H(+)-ATPase-coated vesicles. Using a tissue culture model of collecting duct H(+) secretory cells (inner medullary collecting duct (IMCD) ..
  14. Matsuoka K, Orci L, Amherdt M, Bednarek S, Hamamoto S, Schekman R, et al. COPII-coated vesicle formation reconstituted with purified coat proteins and chemically defined liposomes. Cell. 1998;93:263-75 pubmed
    ..shows that the binding of COPII coat proteins to liposomes results in coated patches, coated buds, and coated vesicles of 50-90 nm in diameter. Budding proceeds without rupture of the donor liposome or vesicle product...
  15. Cao X, Ballew N, Barlowe C. Initial docking of ER-derived vesicles requires Uso1p and Ypt1p but is independent of SNARE proteins. EMBO J. 1998;17:2156-65 pubmed
    ..COPII coated vesicles that have budded from the ER are freely diffusible but then dock to Golgi membranes upon the addition of ..
  16. Aridor M, Bannykh S, Rowe T, Balch W. Sequential coupling between COPII and COPI vesicle coats in endoplasmic reticulum to Golgi transport. J Cell Biol. 1995;131:875-93 pubmed
    ..We propose that sequential coupling between COPII and COPI coats is essential to coordinate and direct bi-directional vesicular traffic between the ER and pre-Golgi intermediates involved in transport of protein to the Golgi complex...
  17. Glick B, Elston T, Oster G. A cisternal maturation mechanism can explain the asymmetry of the Golgi stack. FEBS Lett. 1997;414:177-81 pubmed
    ..This model provides a mechanism for cisternal maturation. If Golgi enzymes compete with one another for packaging into COPI vesicles, we can account for the asymmetric distribution of enzymes across the stack...
  18. Sohn K, Orci L, Ravazzola M, Amherdt M, Bremser M, Lottspeich F, et al. A major transmembrane protein of Golgi-derived COPI-coated vesicles involved in coatomer binding. J Cell Biol. 1996;135:1239-48 pubmed
    Formation of non-clathrin-coated vesicles requires the recruitment of several cytosolic factors to the Golgi membrane...
  19. Fiedler K, Veit M, Stamnes M, Rothman J. Bimodal interaction of coatomer with the p24 family of putative cargo receptors. Science. 1996;273:1396-9 pubmed
    ..The either-or bimodal binding of coatomer to p24 tails suggests models for how coatomer can potentially package retrograde-directed and anterograde-directed cargo into distinct COPI-coated vesicles.
  20. Chu D, Pishvaee B, Payne G. The light chain subunit is required for clathrin function in Saccharomyces cerevisiae. J Biol Chem. 1996;271:33123-30 pubmed
    ..Our results demonstrate that the light chain subunit of clathrin is required for efficient Chc trimerization, proper formation of clathrin coats, and the generation of clathrin-coated vesicles.
  21. VanRheenen S, Cao X, Lupashin V, Barlowe C, Waters M. Sec35p, a novel peripheral membrane protein, is required for ER to Golgi vesicle docking. J Cell Biol. 1998;141:1107-19 pubmed
    ..These genetic and biochemical results suggest Sec35p acts with Uso1p to dock ER-derived vesicles to the Golgi complex...
  22. Mironov A, Luini A, Buccione R. Constitutive transport between the trans-Golgi network and the plasma membrane according to the maturation model. A hypothesis. FEBS Lett. 1998;440:99-102 pubmed
    ..Mature carriers move along microtubules towards the plasma membrane via a microtubule/(kinesin)-based motor system. The maturation and vesicular transport models are compared in terms of consistency with the available literature...
  23. Thay B, Wai S, Oscarsson J. Staphylococcus aureus ?-toxin-dependent induction of host cell death by membrane-derived vesicles. PLoS ONE. 2013;8:e54661 pubmed publisher
    ..This is to our knowledge the first recognition of an S. aureus MV-associated factor contributing to host cell cytotoxicity...
  24. Nie Z, Hirsch D, Randazzo P. Arf and its many interactors. Curr Opin Cell Biol. 2003;15:396-404 pubmed
    ..Recent work examining the functional relationships among the diverse Arf interactors has led to reconsideration of the prevailing paradigms for Arf action...
  25. Denzel A, Otto F, Girod A, Pepperkok R, Watson R, Rosewell I, et al. The p24 family member p23 is required for early embryonic development. Curr Biol. 2000;10:55-8 pubmed
    ..Members of the p24 family have been found in a molecular complex and are enriched in COPI-coated vesicles, which are involved in membrane traffic between the ER and Golgi complex...
  26. Morgan J, Augustine G, Lafer E. Synaptic vesicle endocytosis: the races, places, and molecular faces. Neuromolecular Med. 2002;2:101-14 pubmed
    ..and Reese experiments supported a model in which synaptic vesicle recycling is mediated by the formation of coated vesicles, is relatively slow, and occurs distally from active zones, the sites of neurotransmitter release...
  27. Hinshaw J, Schmid S. Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding. Nature. 1995;374:190-2 pubmed
    ..We propose that invaginated coated pits become constricted by the assembly of dynamin into rings around their necks. A concerted conformational change would then close the rings and pinch off the budding coated vesicles.
  28. Garcia Salcedo J, Perez Morga D, Gijón P, Dilbeck V, Pays E, Nolan D. A differential role for actin during the life cycle of Trypanosoma brucei. EMBO J. 2004;23:780-9 pubmed
    ..These results indicate that actin is required for the formation of coated vesicles from the flagellar pocket membrane, which is the first step in the endocytic pathway...
  29. Bannykh S, Rowe T, Balch W. The organization of endoplasmic reticulum export complexes. J Cell Biol. 1996;135:19-35 pubmed
  30. Vassilieva E, Nusrat A. Vesicular trafficking: molecular tools and targets. Methods Mol Biol. 2008;440:3-14 pubmed publisher
    Intracellular trafficking of membrane-coated vesicles represents a fundamental process that controls the architecture of different intracellular compartments and communication between the cell and its environment...
  31. Beyenbach K. Renal handling of magnesium in fish: from whole animal to brush border membrane vesicles. Front Biosci. 2000;5:D712-9 pubmed
    ..New methods, including Mg imaging and genetic/molecular approaches promise to unravel Mg transport mechanisms in teleost renal tubules...
  32. Antonin W, Riedel D, von Mollard G. The SNARE Vti1a-beta is localized to small synaptic vesicles and participates in a novel SNARE complex. J Neurosci. 2000;20:5724-32 pubmed
    ..This Vti1a-beta was enriched in small synaptic vesicles and clathrin-coated vesicles isolated from nerve terminals...
  33. Li C, Cui J, Wang C, Zhang L, Xiu X, Li Y, et al. Encapsulation of vinorelbine into cholesterol-polyethylene glycol coated vesicles: drug loading and pharmacokinetic studies. J Pharm Pharmacol. 2011;63:376-84 pubmed publisher
    ..To resolve this problem, chol-PEG was used to prepare pegylated liposomal vinorelbine and the factors affecting drug loading and plasma pharmacokinetics were investigated...
  34. Vila Coro A, Mellado M, Martín de Ana A, Martinez A C, Rodriguez Frade J. Characterization of RANTES- and aminooxypentane-RANTES-triggered desensitization signals reveals differences in recruitment of the G protein-coupled receptor complex. J Immunol. 1999;163:3037-44 pubmed
    ..We provide compelling evidence that the differences between RANTES and (AOP)-RANTES in G alpha i activation condition subsequent signaling events, including internalization and receptor recycling...
  35. Liang J, Kornfeld S. Comparative activity of ADP-ribosylation factor family members in the early steps of coated vesicle formation on rat liver Golgi membranes. J Biol Chem. 1997;272:4141-8 pubmed
    ..guanine nucleotide exchange factor and to initiate the formation of clathrin- and coatomer protein (COP) I-coated vesicles on these membranes...
  36. Petrou C, Tashjian A. The thyrotropin-releasing hormone-receptor complex and G11alpha are both internalised into clathrin-coated vesicles. Cell Signal. 1998;10:553-9 pubmed
    ..The localisation of the TRH-TRHR complex and Gq/11alpha was studied by the biochemical isolation of clathrin-coated vesicles (CCVs). The internalised TRH-TRHR complex was localised in CCVs...
  37. Mattheyses A, Atkinson C, Simon S. Imaging single endocytic events reveals diversity in clathrin, dynamin and vesicle dynamics. Traffic. 2011;12:1394-406 pubmed publisher
    ..These results illustrate the heterogeneity of behaviors of endocytic vesicles and the importance of establishing suitable evaluation criteria for biophysical processes...
  38. Henriquez F, Campbell S, Roberts C, Mullen A, Burchmore R, Carter K. Vaccination with recombinant Leishmania donovani gamma-glutamylcysteine synthetase fusion protein protects against L. donovani infection. J Parasitol. 2010;96:929-36 pubmed publisher
    ..01), indicating that using a carrier system did not enhance the protective responses induced by the recombinant protein. The results of this study indicate that Ld?GCS may be a useful component in a vaccine against L. donovani...
  39. Foret L, Sens P. Kinetic regulation of coated vesicle secretion. Proc Natl Acad Sci U S A. 2008;105:14763-8 pubmed publisher
    ..We propose a generic kinetic description of coat assembly and the formation of coated vesicles and discuss its implication to the dynamics of COP vesicles that traffic within the Golgi and with the ..
  40. Kirchhausen T. Bending membranes. Nat Cell Biol. 2012;14:906-8 pubmed publisher
    ..The second reports that membrane crowding, driven by protein-protein interactions, can also drive membrane bending, even in the absence of any protein insertion into the bilayer...
  41. Pontes B, Ayala Y, Fonseca A, Romão L, Amaral R, Salgado L, et al. Membrane elastic properties and cell function. PLoS ONE. 2013;8:e67708 pubmed publisher
    ..For all cell types, the presence of F-actin within tethers, contrary to conventional wisdom, is confirmed. Our findings suggest the existence of a close connection between membrane elastic constants and cell function. ..
  42. du Plessis L, Helena C, van Huysteen E, Wiesner L, Kotze A. Formulation and evaluation of Pheroid vesicles containing mefloquine for the treatment of malaria. J Pharm Pharmacol. 2014;66:14-22 pubmed publisher
    ..However, it has low solubility in water, a long elimination half-life (4 days), and is neurotoxic, which leads to unwanted side effects...
  43. Saso Y, Seki T, Fukuchi R, Chono S, Morimoto K. Effect of lecithin coating on the pulmonary absorption of furosemide in rats. Biol Pharm Bull. 2006;29:1445-8 pubmed
    ..This enhancing effect could also contribute to the high plasma concentration of furosemide in rats. The lecithin-coated furosemide will be useful for the formulation of MDI offering high bioavailability...
  44. Frangakis A, Böhm J, Förster F, Nickell S, Nicastro D, Typke D, et al. Identification of macromolecular complexes in cryoelectron tomograms of phantom cells. Proc Natl Acad Sci U S A. 2002;99:14153-8 pubmed
    ..At the current resolution of approximately 4 nm, macromolecules in the size range of 0.5-1 MDa can be identified with good fidelity...
  45. Kinuta M, Takei K. Utilization of liposomes in vesicular transport studies. Cell Struct Funct. 2002;27:63-9 pubmed
    Various coated vesicles are implicated in the intracellular transport between different compartments...
  46. Litosch I. Regulation of phospholipase C-beta(1) activity by phosphatidic acid. Biochemistry. 2000;39:7736-43 pubmed
    ..The C-terminal-mediated mechanism for stimulation may constitute an important pathway for conferring specific regulation of PLC-beta(1) in response to increases in cellular PA levels...
  47. Nickel W, Brugger B, Wieland F. Protein and lipid sorting between the endoplasmic reticulum and the Golgi complex. Semin Cell Dev Biol. 1998;9:493-501 pubmed
    Vesicular traffic within the early secretory pathway is mediated by COPI- and COPII-coated vesicles. While COPII-coated vesicles appear to be involved exclusively in the export of secretory proteins and lipids from the endoplasmic ..
  48. Barlowe C. COPII and selective export from the endoplasmic reticulum. Biochim Biophys Acta. 1998;1404:67-76 pubmed
    ..experimental observations, a series of integrated events must be accomplished during the formation of COPII coated vesicles. First, the subunits of the COPII coat must be recruited to the correct site on the surface of the ER...
  49. Blackbourn H, Jackson A. Plant clathrin heavy chain: sequence analysis and restricted localisation in growing pollen tubes. J Cell Sci. 1996;109 ( Pt 4):777-86 pubmed
    Clathrin-coated vesicles were isolated from soybean (Glycine max L.) cells in suspension culture and their purity was assessed using SDS-PAGE, peptide sequencing and electron microscopy...
  50. Amborabé B, Bonmort J, Fleurat Lessard P, Roblin G. Early events induced by chitosan on plant cells. J Exp Bot. 2008;59:2317-24 pubmed publisher
    ..As a consequence, chitosan could be preferably used in plant disease control as a powerful elicitor rather than a direct antifungal agent...
  51. Santini F, Keen J. A glimpse of coated vesicle creation? Well almost!. Nat Cell Biol. 2002;4:E230-2 pubmed
  52. Anner B, Volet B. Uptake of reconstituted Na,K-ATPase vesicles by isolated lymphocytes measured by FACS, confocal microscopy and spectrofluorometry. Cell Biochem Biophys. 1999;30:437-54 pubmed
  53. Becker B, Melkonian M. The secretory pathway of protists: spatial and functional organization and evolution. Microbiol Rev. 1996;60:697-721 pubmed
    ..Once a Golgi apparatus was established, it was adapted to the various needs of the different organisms...