transport vesicles

Summary

Summary: Vesicles that are involved in shuttling cargo from the interior of the cell to the cell surface, from the cell surface to the interior, across the cell or around the cell to various locations.

Top Publications

  1. Larimore J, Tornieri K, Ryder P, Gokhale A, Zlatic S, Craige B, et al. The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse. Mol Biol Cell. 2011;22:4854-67 pubmed publisher
    ..Our findings indicate a novel vesicle transport mechanism requiring BLOC-1 and AP-3 complexes for cargo sorting from neuronal cell bodies to neurites and nerve terminals...
  2. van der Kant R, Fish A, Janssen L, Janssen H, Krom S, Ho N, et al. Late endosomal transport and tethering are coupled processes controlled by RILP and the cholesterol sensor ORP1L. J Cell Sci. 2013;126:3462-74 pubmed publisher
  3. Akao Y, Iio A, Itoh T, Noguchi S, Itoh Y, Ohtsuki Y, et al. Microvesicle-mediated RNA molecule delivery system using monocytes/macrophages. Mol Ther. 2011;19:395-9 pubmed publisher
    ..These data suggest that some of the transfected miR-143BPs were secreted from THP-1 macrophages as MV-RNAs both in vitro and in vivo...
  4. McKay J, Wang X, Ding J, Buss J, Ambrosio L. H-ras resides on clathrin-independent ARF6 vesicles that harbor little RAF-1, but not on clathrin-dependent endosomes. Biochim Biophys Acta. 2011;1813:298-307 pubmed publisher
    ..The discrete and dynamic distribution of Ras pathway components with spatio-temporal complexity may contribute to the specificity of Ras:effector interaction...
  5. Luo L, Hannemann M, Koenig S, Hegermann J, Ailion M, Cho M, et al. The Caenorhabditis elegans GARP complex contains the conserved Vps51 subunit and is required to maintain lysosomal morphology. Mol Biol Cell. 2011;22:2564-78 pubmed publisher
    In yeast the Golgi-associated retrograde protein (GARP) complex is required for tethering of endosome-derived transport vesicles to the late Golgi...
  6. Miller S, Sahlender D, Graham S, Höning S, Robinson M, Peden A, et al. The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM. Cell. 2011;147:1118-31 pubmed publisher
    ..CALM's role in directing the endocytosis of small R-SNAREs may provide insight into the association of CALM/PICALM mutations with growth retardation, cognitive defects, and Alzheimer's disease. ..
  7. Zhang H, Abraham N, Khan L, Hall D, Fleming J, GOBEL V. Apicobasal domain identities of expanding tubular membranes depend on glycosphingolipid biosynthesis. Nat Cell Biol. 2011;13:1189-201 pubmed publisher
    ..Our findings identify glycosphingolipids, CGT products and obligate membrane lipids, as critical determinants of in vivo polarity and indicate that they sort new components to the expanding apical membrane...
  8. Xu W, Wang P, Petri B, Zhang Y, Tang W, Sun L, et al. Integrin-induced PIP5K1C kinase polarization regulates neutrophil polarization, directionality, and in vivo infiltration. Immunity. 2010;33:340-50 pubmed publisher
    ..Because integrins are not known to regulate neutrophil polarization, our study revealed a previously underappreciated role of integrin signaling in neutrophil regulation...
  9. Uozumi N, Gao C, Yoshioka T, Nakano M, Moriwaki K, Nakagawa T, et al. Identification of a novel type of CA19-9 carrier in human bile and sera of cancer patients: an implication of the involvement in nonsecretory exocytosis. J Proteome Res. 2010;9:6345-53 pubmed publisher
    ..We measured and visualized BGM in sera of patients with cancer. Thus, BGM might be another CA19-9 carrier (glyco-lipids on membrane vesicles) other than mucins and could be applied to the diagnosis of pancreatic cancer...

More Information

Publications62

  1. Brown F, Pfeffer S. An update on transport vesicle tethering. Mol Membr Biol. 2010;27:457-61 pubmed publisher
    Membrane trafficking involves the collection of cargo into nascent transport vesicles that bud off from a donor compartment, translocate along cytoskeletal tracks, and then dock and fuse with their target membranes...
  2. Sebastian T, Baldridge R, Xu P, Graham T. Phospholipid flippases: building asymmetric membranes and transport vesicles. Biochim Biophys Acta. 2012;1821:1068-77 pubmed publisher
    ..The P4-ATPases also help form transport vesicles that bud from Golgi and endosomal membranes, thereby impacting the sorting and localization of many ..
  3. Toth R, Gerding Reimers C, Deeks M, Menninger S, Gallegos R, Tonaco I, et al. Prieurianin/endosidin 1 is an actin-stabilizing small molecule identified from a chemical genetic screen for circadian clock effectors in Arabidopsis thaliana. Plant J. 2012;71:338-52 pubmed publisher
    ..Pri appears to stabilize actin filaments by a different mechanism from previously described inhibitors, and will be a useful tool to study actin-related cellular processes...
  4. Osmani N, Peglion F, Chavrier P, Etienne Manneville S. Cdc42 localization and cell polarity depend on membrane traffic. J Cell Biol. 2010;191:1261-9 pubmed publisher
    ..Our results demonstrate influence of membrane dynamics on the localization and activation of Cdc42 and consequently on directed cell migration...
  5. Savage N, Layton A, Lew D. Mechanistic mathematical model of polarity in yeast. Mol Biol Cell. 2012;23:1998-2013 pubmed publisher
    ..These findings indicate that vesicle-mediated delivery of Cdc42p is not required to explain the observed Cdc42p dynamics, and raise the question of whether such Cdc42p traffic actually contributes to polarity establishment...
  6. Hudoklin S, Jezernik K, Neumüller J, Pavelka M, Romih R. Urothelial plaque formation in post-Golgi compartments. PLoS ONE. 2011;6:e23636 pubmed publisher
    ..With additional fusions and buddings, iFVs mature into mFVs, each carrying two urothelial plaques toward the apical surface of the umbrella cell...
  7. Kelly B, Owen D. Endocytic sorting of transmembrane protein cargo. Curr Opin Cell Biol. 2011;23:404-12 pubmed publisher
    ..cargo destined for clathrin-mediated endocytosis and transport along the endocytic pathway is sorted into transport vesicles by interactions with adaptors, which simultaneously link clathrin to the membrane...
  8. Itzen A, Goody R. GTPases involved in vesicular trafficking: structures and mechanisms. Semin Cell Dev Biol. 2011;22:48-56 pubmed publisher
    ..The basic structural and mechanistic properties of these proteins and their interactions with partner proteins and membranes are reviewed and compared in this article...
  9. Ueno H, Huang X, Tanaka Y, Hirokawa N. KIF16B/Rab14 molecular motor complex is critical for early embryonic development by transporting FGF receptor. Dev Cell. 2011;20:60-71 pubmed publisher
    ..These data provide one of the first pieces of genetic evidence that microtubule-based membrane trafficking directly promotes early development...
  10. Peremyslov V, Morgun E, Kurth E, Makarova K, Koonin E, Dolja V. Identification of myosin XI receptors in Arabidopsis defines a distinct class of transport vesicles. Plant Cell. 2013;25:3022-38 pubmed publisher
    ..Collectively, these findings indicate that MyoB are membrane-anchored myosin receptors that define a distinct, plant-specific transport vesicle compartment...
  11. Linz J, Chanda A, Hong S, Whitten D, Wilkerson C, Roze L. Proteomic and biochemical evidence support a role for transport vesicles and endosomes in stress response and secondary metabolism in Aspergillus parasiticus. J Proteome Res. 2012;11:767-75 pubmed publisher
    ..To address this hypothesis, we purified a cellular fraction containing endosomes, transport vesicles, and vacuoles (V fraction) from A. parasiticus grown under aflatoxin inducing and noninducing conditions...
  12. Al Bassam S, Xu M, Wandless T, Arnold D. Differential trafficking of transport vesicles contributes to the localization of dendritic proteins. Cell Rep. 2012;2:89-100 pubmed publisher
    ..release of exogenous transmembrane proteins from the endoplasmic reticulum to follow movements of post-Golgi transport vesicles. Surprisingly, we found that post-Golgi vesicles carrying dendritic proteins were equally likely to enter ..
  13. Soubannier V, McLelland G, Zunino R, Braschi E, Rippstein P, Fon E, et al. A vesicular transport pathway shuttles cargo from mitochondria to lysosomes. Curr Biol. 2012;22:135-41 pubmed publisher
    ..These data characterize a novel vesicle transport route between the mitochondria and lysosomes, providing insights into the basic mechanisms of mitochondrial quality control...
  14. Fujita H, Hatakeyama H, Watanabe T, Sato M, Higuchi H, Kanzaki M. Identification of three distinct functional sites of insulin-mediated GLUT4 trafficking in adipocytes using quantitative single molecule imaging. Mol Biol Cell. 2010;21:2721-31 pubmed publisher
    ..In addition, our novel approach revealed the possibility that, in certain insulin-resistant states, derangements in GLUT4 behavior can impair insulin-responsive GLUT4 translocation. ..
  15. Andrade Navarro M, Sanchez Pulido L, McBride H. Mitochondrial vesicles: an ancient process providing new links to peroxisomes. Curr Opin Cell Biol. 2009;21:560-7 pubmed publisher
    ..This review will explore the mechanism and function of mitochondrial vesicle transport with an eye toward the evolutionary implications of this new pathway in cell biology...
  16. Yu I, Hughson F. Tethering factors as organizers of intracellular vesicular traffic. Annu Rev Cell Dev Biol. 2010;26:137-56 pubmed publisher
    Intracellular trafficking entails the budding, transport, tethering, and fusion of transport vesicles and other membrane carriers. Here we review recent progress toward a mechanistic understanding of vesicle tethering...
  17. Hata T, Murakami K, Nakatani H, Yamamoto Y, Matsuda T, Aoki N. Isolation of bovine milk-derived microvesicles carrying mRNAs and microRNAs. Biochem Biophys Res Commun. 2010;396:528-33 pubmed publisher
    ..Our findings suggest that bovine breast milk contains RNAs capable for being transferred to living cells and involved in the development of calf's gastrointestinal and immune systems...
  18. Lopez J, Burchfield J, Blair D, Mele K, Ng Y, Vallotton P, et al. Identification of a distal GLUT4 trafficking event controlled by actin polymerization. Mol Biol Cell. 2009;20:3918-29 pubmed publisher
    ..These data clearly resolve multiple steps of the final stages of GLUT4 trafficking, demonstrating a crucial role for actin in the final stage of this process. ..
  19. Anderson H, Mulhall D, Garimella R. Role of extracellular membrane vesicles in the pathogenesis of various diseases, including cancer, renal diseases, atherosclerosis, and arthritis. Lab Invest. 2010;90:1549-57 pubmed publisher
    ..The main objective of this review is to list and briefly describe the increasingly well-defined roles of MVs in selected diseases in which they seem to have a significant role in pathogenesis...
  20. Dippold H, Ng M, Farber Katz S, Lee S, Kerr M, Peterman M, et al. GOLPH3 bridges phosphatidylinositol-4- phosphate and actomyosin to stretch and shape the Golgi to promote budding. Cell. 2009;139:337-51 pubmed publisher
    ..Consequently, this tensile force stretches the Golgi into the extended ribbon observed by fluorescence microscopy and the familiar flattened form observed by electron microscopy...
  21. Angers C, Merz A. HOPS interacts with Apl5 at the vacuole membrane and is required for consumption of AP-3 transport vesicles. Mol Biol Cell. 2009;20:4563-74 pubmed publisher
    ..We propose that AP-3 remains associated with budded vesicles, interacts with Vps41 and HOPS upon vesicle docking at the vacuole, and finally dissociates during docking or fusion. ..
  22. Pankiv S, Alemu E, Brech A, Bruun J, Lamark T, Overvatn A, et al. FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport. J Cell Biol. 2010;188:253-69 pubmed publisher
    ..We also propose a mechanism for selective autophagosomal membrane recruitment of FYCO1...
  23. Wollert T, Wunder C, Lippincott Schwartz J, Hurley J. Membrane scission by the ESCRT-III complex. Nature. 2009;458:172-7 pubmed publisher
    ..The minimum set of ESCRT-III and Vps4 proteins capable of multiple cycles of vesicle detachment corresponds to the ancient set of ESCRT proteins conserved from archaea to animals. ..
  24. Rebersek M, Kranjc M, Pavliha D, Batista Napotnik T, Vrtacnik D, Amon S, et al. Blumlein configuration for high-repetition-rate pulse generation of variable duration and polarity using synchronized switch control. IEEE Trans Biomed Eng. 2009;56:2642-8 pubmed publisher
  25. Williams D, Vicogne J, Zaitseva I, McLaughlin S, Pessin J. Evidence that electrostatic interactions between vesicle-associated membrane protein 2 and acidic phospholipids may modulate the fusion of transport vesicles with the plasma membrane. Mol Biol Cell. 2009;20:4910-9 pubmed publisher
    ..We propose a model in which the positively charged VAMP and syntaxin juxtamembrane regions facilitate fusion by bridging the negatively charged vesicle and plasma membrane leaflets. ..
  26. Napoletano C, Rughetti A, Landi R, Pinto D, Bellati F, Rahimi H, et al. Immunogenicity of allo-vesicle carrying ERBB2 tumor antigen for dendritic cell-based anti-tumor immunotherapy. Int J Immunopathol Pharmacol. 2009;22:647-58 pubmed
    ..The microvesicle cell factory proposed may represent a source of cell free immunogen to be used for DC-based cancer therapy...
  27. Braschi E, Goyon V, Zunino R, Mohanty A, Xu L, McBride H. Vps35 mediates vesicle transport between the mitochondria and peroxisomes. Curr Biol. 2010;20:1310-5 pubmed publisher
    ..Silencing of Vps35 or Vps26A leads to a significant reduction in the delivery of MAPL to peroxisomes, placing the retromer within a novel intracellular trafficking route and providing insight into the formation of MAPL-positive MDVs...
  28. Zhang Z, Jackson M. Membrane bending energy and fusion pore kinetics in Ca(2+)-triggered exocytosis. Biophys J. 2010;98:2524-34 pubmed publisher
    ..Ca(2+)-triggered exocytosis begins with a proteinaceous fusion pore with less stressed membrane, and becomes lipidic as it dilates, bending membrane into a highly curved shape...
  29. Ren Y, Yip C, Tripathi A, Huie D, Jeffrey P, Walz T, et al. A structure-based mechanism for vesicle capture by the multisubunit tethering complex Dsl1. Cell. 2009;139:1119-29 pubmed publisher
    ..Our results suggest that even the simplest MTC may be capable of orchestrating vesicle capture, uncoating, and fusion...
  30. Insinna C, Baye L, Amsterdam A, Besharse J, Link B. Analysis of a zebrafish dync1h1 mutant reveals multiple functions for cytoplasmic dynein 1 during retinal photoreceptor development. Neural Dev. 2010;5:12 pubmed publisher
    ..Proper morphogenesis of photoreceptor neurons is essential for their normal function and survival. We have characterized a zebrafish mutation, cannonball, that completely disrupts photoreceptor morphogenesis...
  31. Ellis T, Kuehn M. Virulence and immunomodulatory roles of bacterial outer membrane vesicles. Microbiol Mol Biol Rev. 2010;74:81-94 pubmed publisher
    ..Vesicles display antigens and can elicit potent inflammatory and immune responses. In sum, OM vesicles are likely to play a significant role in the virulence of Gram-negative bacterial pathogens...
  32. Hager H, Roberts R, Cross E, Proux Gillardeaux V, Bader D. Identification of a novel Bves function: regulation of vesicular transport. EMBO J. 2010;29:532-45 pubmed publisher
    ..Thus, this study establishes a newly identified role for Bves in vesicular transport and reveals a novel, broadly applied mechanism governing SNARE protein function...
  33. Pucadyil T, Schmid S. Real-time visualization of dynamin-catalyzed membrane fission and vesicle release. Cell. 2008;135:1263-75 pubmed publisher
    ..Thus, self-limited assemblies of dynamin generated in the constant presence of GTP catalyze membrane fission...
  34. de Haan C, Molinari M, Reggiori F. Autophagy-independent LC3 function in vesicular traffic. Autophagy. 2010;6:994-6 pubmed publisher
    ..While it seems clear that CoVs hijack ER-derived host cell membranes for replication, the mechanism by which these DMVs are assembled has remained completely mysterious...
  35. Bogan J, Kandror K. Biogenesis and regulation of insulin-responsive vesicles containing GLUT4. Curr Opin Cell Biol. 2010;22:506-12 pubmed publisher
    ..In addition to acting at other steps in vesicle recycling, insulin releases this retention mechanism to promote the translocation and fusion of the vesicles at the cell surface...
  36. Fletcher S, Rappoport J. Moving forward: polarised trafficking in cell migration. Trends Cell Biol. 2010;20:71-8 pubmed publisher
    ..Further research is required to confirm our hypothesis and a systematic evaluation of multiple pathways within individual systems and across different models is needed...
  37. Szodorai A, Kuan Y, Hunzelmann S, Engel U, Sakane A, Sasaki T, et al. APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle. J Neurosci. 2009;29:14534-44 pubmed publisher
    ..Finally, we show cleavage of APP in transport vesicles by alpha-secretase activity, likely mediated by ADAM10...
  38. Liu J, Sun Y, Drubin D, Oster G. The mechanochemistry of endocytosis. PLoS Biol. 2009;7:e1000204 pubmed publisher
    ..The combination of experiments and theory in this work suggest a unified mechanism for endocytic vesicle formation across eukaryotes...
  39. Hsiao Y, Tong Z, Westfall J, Ault J, Page McCaw P, Ferland R. Ahi1, whose human ortholog is mutated in Joubert syndrome, is required for Rab8a localization, ciliogenesis and vesicle trafficking. Hum Mol Genet. 2009;18:3926-41 pubmed publisher
    ..Overall, our data indicate that the distribution and functioning of Rab8a is regulated by Ahi1, not only affecting cilium formation, but also vesicle transport...
  40. Stenmark H. Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol. 2009;10:513-25 pubmed publisher
    ..Functional impairments of Rab pathways are associated with diseases, such as immunodeficiencies, cancer and neurological disorders...
  41. Jaiswal J, Rivera V, Simon S. Exocytosis of post-Golgi vesicles is regulated by components of the endocytic machinery. Cell. 2009;137:1308-19 pubmed publisher
    ..Our results demonstrate that these components of the endocytic machinery modulate the nature and extent of biosynthetic cargo delivery by post-Golgi vesicles at the cell membrane...
  42. Wei S, Xie C, Abe Y, Cai J. ADP-ribosylation factor like 7 (ARL7) interacts with alpha-tubulin and modulates intracellular vesicular transport. Biochem Biophys Res Commun. 2009;384:352-6 pubmed publisher
    ..The above data suggested that ARL7 might modulate the intracellular vesicular transport via interaction with microtubules...
  43. Bomberger J, Maceachran D, Coutermarsh B, Ye S, O Toole G, Stanton B. Long-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesicles. PLoS Pathog. 2009;5:e1000382 pubmed publisher
  44. Stein I, Gottfried A, Zimmermann J, Fischer von Mollard G. TVP23 interacts genetically with the yeast SNARE VTI1 and functions in retrograde transport from the early endosome to the late Golgi. Biochem J. 2009;419:229-36 pubmed publisher
    ..fusion protein-attachment protein receptor) proteins contribute to specific recognition between transport vesicles and target membranes and are required for fusion of membranes...
  45. Podyma Inoue K, Moriwaki T, Rajapakshe A, Terasawa K, Hara Yokoyama M. Characterization of Heparan Sulfate Proteoglycan-positive Recycling Endosomes Isolated from Glioma Cells. Cancer Genomics Proteomics. 2016;13:443-452 pubmed
    ..Part of HSPGs in glioma cells is internalized through clathrin-dependent endocytosis and undergo recycling. The development of compounds regulating HSPG-mediated trafficking will likely enable design of effective glioma treatment. ..
  46. Nakagawa H, Umadome H, Miyazaki S, Tanaka K, Nishimura K, Komori M, et al. ER-resident Gi2 protein controls sar1 translocation onto the ER during budding of transport vesicles. J Cell Biochem. 2011;112:2250-6 pubmed publisher
  47. Tenreiro S, Rosado Ramos R, Gerhardt E, Favretto F, Magalhães F, Popova B, et al. Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity. Hum Mol Genet. 2016;25:275-90 pubmed publisher
  48. Beilina A, Rudenko I, Kaganovich A, Civiero L, Chau H, Kalia S, et al. Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease. Proc Natl Acad Sci U S A. 2014;111:2626-31 pubmed publisher
    ..We propose that three different genes for PD have a common biological function. More generally, data integration from multiple unbiased screens can provide insight into human disease mechanisms. ..
  49. Turturici G, Tinnirello R, Sconzo G, Geraci F. Extracellular membrane vesicles as a mechanism of cell-to-cell communication: advantages and disadvantages. Am J Physiol Cell Physiol. 2014;306:C621-33 pubmed publisher
    ..In addition, stem cell-derived EVs may induce the de-differentiation of cells that survive injury by promoting their reentry into the cell cycle and subsequently increasing the possibility of tissue regeneration. ..
  50. Gordon S, Cousin M. X-linked intellectual disability-associated mutations in synaptophysin disrupt synaptobrevin II retrieval. J Neurosci. 2013;33:13695-700 pubmed publisher
  51. Straud S, Lee I, Song B, Avery L, You Y. The jaw of the worm: GTPase-activating protein EAT-17 regulates grinder formation in Caenorhabditis elegans. Genetics. 2013;195:115-25 pubmed publisher
    ..2. Based on the conserved function of Rab6 in vesicular transport, we propose that EAT-17 regulates the turnover rate of RAB-6.2 activity in cargo trafficking for grinder formation. ..
  52. Reimer R. SLC17: a functionally diverse family of organic anion transporters. Mol Aspects Med. 2013;34:350-9 pubmed publisher
  53. Gouffon C, van Vliet A, Van Rie J, Jansens S, Jurat Fuentes J. Binding sites for Bacillus thuringiensis Cry2Ae toxin on heliothine brush border membrane vesicles are not shared with Cry1A, Cry1F, or Vip3A toxin. Appl Environ Microbiol. 2011;77:3182-8 pubmed publisher
    ..Our data support the use of Cry2Ae toxin in combination with Cry1 or Vip3A toxins in strategies to increase target range and delay the onset of heliothine resistance...