cytoplasmic vesicles

Summary

Summary: Membrane-limited structures derived from the plasma membrane or various intracellular membranes which function in storage, transport or metabolism.

Top Publications

  1. Miller M, Furlong W, Pennell L, Geadah M, Hertel L. RASCAL is a new human cytomegalovirus-encoded protein that localizes to the nuclear lamina and in cytoplasmic vesicles at late times postinfection. J Virol. 2010;84:6483-96 pubmed publisher
    ..Here, we describe the identification of a new CMV protein localizing to the nuclear envelope and in cytoplasmic vesicles at late times postinfection...
  2. Thery C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol. 2009;9:581-93 pubmed publisher
    ..This Review focuses on the role of membrane vesicles, in particular exosomes, in the communication between immune cells, and between tumour and immune cells...
  3. Herrera M, Fonsato V, Gatti S, Deregibus M, Sordi A, Cantarella D, et al. Human liver stem cell-derived microvesicles accelerate hepatic regeneration in hepatectomized rats. J Cell Mol Med. 2010;14:1605-18 pubmed publisher
    ..In conclusion, these results suggest that MVs derived from HLSC may activate a proliferative program in remnant hepatocytes after hepatectomy by a horizontal transfer of specific mRNA subsets...
  4. Oliveira D, Nimrichter L, Miranda K, Frases S, Faull K, Casadevall A, et al. Cryptococcus neoformans cryoultramicrotomy and vesicle fractionation reveals an intimate association between membrane lipids and glucuronoxylomannan. Fungal Genet Biol. 2009;46:956-63 pubmed publisher
    ..These results indicate an intimate association of GXM and lipids in both intracellular and extracellular spaces consistent with polysaccharide synthesis and transport in membrane-associated structures...
  5. Golub E. Role of matrix vesicles in biomineralization. Biochim Biophys Acta. 2009;1790:1592-8 pubmed publisher
    ..During this period, their exact role, if any in the nucleation of hydroxyapatite mineral, and its subsequent association with the collagen fibrils in the organic matrix has been debated and remains controversial...
  6. Chen Y, Wang Y, Zhang J, Deng Y, Jiang L, Song E, et al. Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes. J Cell Biol. 2012;198:545-60 pubmed publisher
    ..Thus, multiple Rab proteins regulate the trafficking of GLUT4, with Rab10 coordinating with myosin-Va to mediate the final steps of insulin-stimulated GSV translocation to the PM...
  7. Collino F, Deregibus M, Bruno S, Sterpone L, Aghemo G, Viltono L, et al. Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs. PLoS ONE. 2010;5:e11803 pubmed publisher
    ..The aim of the present study was to evaluate whether MVs derived from MSCs and HLSCs contained selected micro-RNAs (miRNAs)...
  8. Chung L, Hosaka T, Harada N, Jambaldorj B, Fukunaga K, Nishiwaki Y, et al. Myosin IIA participates in docking of Glut4 storage vesicles with the plasma membrane in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2010;391:995-9 pubmed publisher
    ..These data suggest that myosin IIA plays a role in insulin-stimulated docking of GSVs to the PM in 3T3-L1 adipocytes through SNARE complex formation...
  9. Yen W, Shintani T, Nair U, Cao Y, Richardson B, Li Z, et al. The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy. J Cell Biol. 2010;188:101-14 pubmed publisher
    ..In addition, mutations in the COG genes resulted in the mislocalization of Atg8 and Atg9, which are critical components involved in autophagosome formation...
  10. Sustar V, Bedina Zavec A, Stukelj R, Frank M, Bobojevic G, Jansa R, et al. Nanoparticles isolated from blood: a reflection of vesiculability of blood cells during the isolation process. Int J Nanomedicine. 2011;6:2737-48 pubmed publisher
    ..We addressed this question by determination of the morphology and identity of nanoparticles harvested from blood...

Detail Information

Publications62

  1. Miller M, Furlong W, Pennell L, Geadah M, Hertel L. RASCAL is a new human cytomegalovirus-encoded protein that localizes to the nuclear lamina and in cytoplasmic vesicles at late times postinfection. J Virol. 2010;84:6483-96 pubmed publisher
    ..Here, we describe the identification of a new CMV protein localizing to the nuclear envelope and in cytoplasmic vesicles at late times postinfection...
  2. Thery C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol. 2009;9:581-93 pubmed publisher
    ..This Review focuses on the role of membrane vesicles, in particular exosomes, in the communication between immune cells, and between tumour and immune cells...
  3. Herrera M, Fonsato V, Gatti S, Deregibus M, Sordi A, Cantarella D, et al. Human liver stem cell-derived microvesicles accelerate hepatic regeneration in hepatectomized rats. J Cell Mol Med. 2010;14:1605-18 pubmed publisher
    ..In conclusion, these results suggest that MVs derived from HLSC may activate a proliferative program in remnant hepatocytes after hepatectomy by a horizontal transfer of specific mRNA subsets...
  4. Oliveira D, Nimrichter L, Miranda K, Frases S, Faull K, Casadevall A, et al. Cryptococcus neoformans cryoultramicrotomy and vesicle fractionation reveals an intimate association between membrane lipids and glucuronoxylomannan. Fungal Genet Biol. 2009;46:956-63 pubmed publisher
    ..These results indicate an intimate association of GXM and lipids in both intracellular and extracellular spaces consistent with polysaccharide synthesis and transport in membrane-associated structures...
  5. Golub E. Role of matrix vesicles in biomineralization. Biochim Biophys Acta. 2009;1790:1592-8 pubmed publisher
    ..During this period, their exact role, if any in the nucleation of hydroxyapatite mineral, and its subsequent association with the collagen fibrils in the organic matrix has been debated and remains controversial...
  6. Chen Y, Wang Y, Zhang J, Deng Y, Jiang L, Song E, et al. Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes. J Cell Biol. 2012;198:545-60 pubmed publisher
    ..Thus, multiple Rab proteins regulate the trafficking of GLUT4, with Rab10 coordinating with myosin-Va to mediate the final steps of insulin-stimulated GSV translocation to the PM...
  7. Collino F, Deregibus M, Bruno S, Sterpone L, Aghemo G, Viltono L, et al. Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs. PLoS ONE. 2010;5:e11803 pubmed publisher
    ..The aim of the present study was to evaluate whether MVs derived from MSCs and HLSCs contained selected micro-RNAs (miRNAs)...
  8. Chung L, Hosaka T, Harada N, Jambaldorj B, Fukunaga K, Nishiwaki Y, et al. Myosin IIA participates in docking of Glut4 storage vesicles with the plasma membrane in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2010;391:995-9 pubmed publisher
    ..These data suggest that myosin IIA plays a role in insulin-stimulated docking of GSVs to the PM in 3T3-L1 adipocytes through SNARE complex formation...
  9. Yen W, Shintani T, Nair U, Cao Y, Richardson B, Li Z, et al. The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy. J Cell Biol. 2010;188:101-14 pubmed publisher
    ..In addition, mutations in the COG genes resulted in the mislocalization of Atg8 and Atg9, which are critical components involved in autophagosome formation...
  10. Sustar V, Bedina Zavec A, Stukelj R, Frank M, Bobojevic G, Jansa R, et al. Nanoparticles isolated from blood: a reflection of vesiculability of blood cells during the isolation process. Int J Nanomedicine. 2011;6:2737-48 pubmed publisher
    ..We addressed this question by determination of the morphology and identity of nanoparticles harvested from blood...
  11. Mukerjee P, Ostrow J. Interactions of unconjugated bilirubin with vesicles, cyclodextrins and micelles: new modeling and the role of high pKa values. BMC Biochem. 2010;11:16 pubmed publisher
  12. Szajnik M, Czystowska M, Szczepanski M, Mandapathil M, Whiteside T. Tumor-derived microvesicles induce, expand and up-regulate biological activities of human regulatory T cells (Treg). PLoS ONE. 2010;5:e11469 pubmed publisher
    ..The hypothesis is tested that TMV contribute to induction/expansion/and activation of human Treg...
  13. Chanda A, Roze L, Kang S, Artymovich K, Hicks G, Raikhel N, et al. A key role for vesicles in fungal secondary metabolism. Proc Natl Acad Sci U S A. 2009;106:19533-8 pubmed publisher
    ..We propose a unique 2-branch model to illustrate the proposed role for VeA in regulation of aflatoxisome development and aflatoxin gene expression...
  14. Jedrychowski M, Gartner C, Gygi S, Zhou L, Herz J, Kandror K, et al. Proteomic analysis of GLUT4 storage vesicles reveals LRP1 to be an important vesicle component and target of insulin signaling. J Biol Chem. 2010;285:104-14 pubmed publisher
    ..Furthermore, adipose-specific LRP1 knock-out mice also exhibit decreased GLUT4 expression. These findings suggest LRP1 is an important component of GSVs, and its expression is needed for the formation of fully functional GSVs...
  15. Yang Z, Klionsky D. An overview of the molecular mechanism of autophagy. Curr Top Microbiol Immunol. 2009;335:1-32 pubmed publisher
    ..Here, we summarize our current knowledge about the machinery and molecular mechanism of autophagy...
  16. Sremac M, Stuart E. SIVsm Tat, Rev, and Nef1: functional characteristics of r-GV internalization on isotypes, cytokines, and intracellular degradation. BMC Biotechnol. 2010;10:54 pubmed publisher
    ..1 macrophage cells to degrade these internalized display/delivery particles in vitro were examined...
  17. Dolezal P, Dagley M, Kono M, Wolynec P, Liki V, Foo J, et al. The essentials of protein import in the degenerate mitochondrion of Entamoeba histolytica. PLoS Pathog. 2010;6:e1000812 pubmed publisher
    ..histolytica...
  18. Dell Era S, Buchrieser C, Couve E, Schnell B, Briers Y, Schuppler M, et al. Listeria monocytogenes L-forms respond to cell wall deficiency by modifying gene expression and the mode of division. Mol Microbiol. 2009;73:306-22 pubmed publisher
  19. Simons M, Raposo G. Exosomes--vesicular carriers for intercellular communication. Curr Opin Cell Biol. 2009;21:575-81 pubmed publisher
    ..Only recently light have been shed on the subcellular compartments and mechanisms involved in their biogenesis and secretion opening new avenues to understand their functions...
  20. Amaravadi R, Lippincott Schwartz J, Yin X, Weiss W, Takebe N, Timmer W, et al. Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res. 2011;17:654-66 pubmed publisher
    ..Finally, we describe ongoing clinical trials involving HCQ as a first generation autophagy inhibitor, as well as strategies for the development of novel, more potent, and specific inhibitors of autophagy...
  21. Childs T, Webley W. In vitro assessment of halobacterial gas vesicles as a Chlamydia vaccine display and delivery system. Vaccine. 2012;30:5942-8 pubmed publisher
    ..The data suggest that r-GV could be an effective, naturally adjuvanting, time-release antigen delivery system for immunologically relevant Chlamydia vaccine antigens which are readily recognized by human immune sera...
  22. Schuh M. An actin-dependent mechanism for long-range vesicle transport. Nat Cell Biol. 2011;13:1431-6 pubmed publisher
    ..Thus, collective movement within a network is a powerful and flexible mode of vesicle transport...
  23. Lee E, Choi D, Kim D, Kim J, Park J, Kim S, et al. Gram-positive bacteria produce membrane vesicles: proteomics-based characterization of Staphylococcus aureus-derived membrane vesicles. Proteomics. 2009;9:5425-36 pubmed publisher
    ..This information will help us not only to elucidate the biogenesis and functions of MVs, but also to develop therapeutic tools for vaccines, diagnosis, and antibiotics effective against pathogenic strains of Gram-positive bacteria...
  24. Bergmann C, Strauss L, Wieckowski E, Czystowska M, Albers A, Wang Y, et al. Tumor-derived microvesicles in sera of patients with head and neck cancer and their role in tumor progression. Head Neck. 2009;31:371-80 pubmed publisher
    ..We tested if MV molecular profile and activity correlate with disease progression...
  25. Jiang L, Fan J, Bai L, Wang Y, Chen Y, Yang L, et al. Direct quantification of fusion rate reveals a distal role for AS160 in insulin-stimulated fusion of GLUT4 storage vesicles. J Biol Chem. 2008;283:8508-16 pubmed
  26. Lakkaraju A, Rodriguez Boulan E. Itinerant exosomes: emerging roles in cell and tissue polarity. Trends Cell Biol. 2008;18:199-209 pubmed publisher
    ..In this review, we discuss new evidence suggesting that exosomes participate in the transport of morphogens and RNA, and thus influence cell polarity and developmental patterning of tissues...
  27. Griffiths G, Galileo D, Reese K, Martin DeLeon P. Investigating the role of murine epididymosomes and uterosomes in GPI-linked protein transfer to sperm using SPAM1 as a model. Mol Reprod Dev. 2008;75:1627-36 pubmed publisher
    ..Taken together, these results implicate vesicular docking as the mechanism of vesicle-mediated GPI-linked protein transfer to sperm from murine reproductive fluids...
  28. Salzer U, Zhu R, Luten M, Isobe H, Pastushenko V, Perkmann T, et al. Vesicles generated during storage of red cells are rich in the lipid raft marker stomatin. Transfusion. 2008;48:451-62 pubmed
    ..The characterization of the vesicular membrane might hint at the underlying mechanism of the storage-associated changes in general and the vesiculation process in particular...
  29. Soper J, Roy S, Stieber A, Lee E, Wilson R, Trojanowski J, et al. Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae. Mol Biol Cell. 2008;19:1093-103 pubmed publisher
  30. Bobryshev Y, Killingsworth M, Lord R, Grabs A. Matrix vesicles in the fibrous cap of atherosclerotic plaque: possible contribution to plaque rupture. J Cell Mol Med. 2008;12:2073-82 pubmed publisher
    ..705+/-0.436 versus 5.322+/-0494; P= 0.0474). The findings reinforce a view that the texture of the extracellular matrix in the thinning fibrous cap of atherosclerotic plaque is altered and this might contribute to plaque destabilization...
  31. Sremac M, Stuart E. Recombinant gas vesicles from Halobacterium sp. displaying SIV peptides demonstrate biotechnology potential as a pathogen peptide delivery vehicle. BMC Biotechnol. 2008;8:9 pubmed publisher
    ..Tests using mice indicated that the humoral immune response to the gag encoded sequences evoked immunologic memory in the absence of an exogenous adjuvant...
  32. Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F, et al. Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science. 2008;319:1244-7 pubmed publisher
    ..Purified exosomes were enriched in ceramide, and the release of exosomes was reduced after the inhibition of neutral sphingomyelinases. These results establish a pathway in intraendosomal membrane transport and exosome formation...
  33. Bosman G, Lasonder E, Luten M, Roerdinkholder Stoelwinder B, Novotný V, Bos H, et al. The proteome of red cell membranes and vesicles during storage in blood bank conditions. Transfusion. 2008;48:827-35 pubmed publisher
    ..To be able to identify the mechanisms underlying these storage lesions, a proteomic analysis of the membranes of RBCs and their vesicles was performed during various periods of storage in blood bank conditions...
  34. Styers M, O Connor A, Grabski R, Cormet Boyaka E, Sztul E. Depletion of beta-COP reveals a role for COP-I in compartmentalization of secretory compartments and in biosynthetic transport of caveolin-1. Am J Physiol Cell Physiol. 2008;294:C1485-98 pubmed publisher
    ..Our findings suggest that COP-I is required for the compartmentalization of the ERGIC, Golgi, TGN, and recycling endosomes and that COP-I plays a novel role in the biosynthetic transport of Cav1...
  35. Jansa R, Sustar V, Frank M, Susanj P, Bester J, Mancek Keber M, et al. Number of microvesicles in peripheral blood and ability of plasma to induce adhesion between phospholipid membranes in 19 patients with gastrointestinal diseases. Blood Cells Mol Dis. 2008;41:124-32 pubmed publisher
    ..033) and smaller average effective angle of contact (difference 20%, statistical significance 0.013) compared to patients with other gastrointestinal diseases...
  36. Kriebardis A, Antonelou M, Stamoulis K, Economou Petersen E, Margaritis L, Papassideri I. RBC-derived vesicles during storage: ultrastructure, protein composition, oxidation, and signaling components. Transfusion. 2008;48:1943-53 pubmed publisher
    ..The vesiculation of the RBCs is a part of the storage lesion. The protein composition of the vesicles generated during storage of banked RBCs has not been studied in detail...
  37. Castillon G, Watanabe R, Taylor M, Schwabe T, Riezman H. Concentration of GPI-anchored proteins upon ER exit in yeast. Traffic. 2009;10:186-200 pubmed publisher
    ..Additionally, we have found that GPI-anchored protein ER exit is controlled by the p24 family member Emp24p, whereas ER export of most transmembrane proteins requires the Cornichon homologue Erv14p...
  38. Lee D, Riquier A, Yang L, Leong P, Maunsbach A, McDonough A. Acute hypertension provokes acute trafficking of distal tubule Na-Cl cotransporter (NCC) to subapical cytoplasmic vesicles. Am J Physiol Renal Physiol. 2009;296:F810-8 pubmed publisher
    ..cotransporter (NCC) is regulated by trafficking between the apical plasma membrane (APM) and subapical cytoplasmic vesicles (SCV)...
  39. Iero M, Valenti R, Huber V, Filipazzi P, Parmiani G, Fais S, et al. Tumour-released exosomes and their implications in cancer immunity. Cell Death Differ. 2008;15:80-8 pubmed
    ..Hence, their secretion by neoplastic cells may in the future become a novel pathway to target for therapeutic intervention in cancer patients...
  40. Gambim M, do Carmo A, Marti L, Verissimo Filho S, Lopes L, Janiszewski M. Platelet-derived exosomes induce endothelial cell apoptosis through peroxynitrite generation: experimental evidence for a novel mechanism of septic vascular dysfunction. Crit Care. 2007;11:R107 pubmed
    ..We sought to further characterize the microparticle-dependent vascular injury pathway...
  41. Schorey J, Bhatnagar S. Exosome function: from tumor immunology to pathogen biology. Traffic. 2008;9:871-81 pubmed publisher
    ..In this review, we summarize our understanding of exosome biogenesis but focus primarily on new insights into exosome function. We also discuss their possible use as disease biomarkers and vaccine candidates...
  42. Frank M, Mancek Keber M, Krzan M, Sodin Semrl S, Jerala R, Iglic A, et al. Prevention of microvesiculation by adhesion of buds to the mother cell membrane--a possible anticoagulant effect of healthy donor plasma. Autoimmun Rev. 2008;7:240-5 pubmed publisher
    ..Plasma that mediates stronger attractive interaction between GPVs might potentially be associated with a smaller risk of thrombosis...
  43. Pranke I, Morello V, Bigay J, Gibson K, Verbavatz J, Antonny B, et al. ?-Synuclein and ALPS motifs are membrane curvature sensors whose contrasting chemistry mediates selective vesicle binding. J Cell Biol. 2011;194:89-103 pubmed publisher
    ..Through structures with complementary chemistries, ?-synuclein and ALPS motifs target distinct vesicles in cells by direct interaction with different lipid environments...
  44. Galindo Hernandez O, Villegas Comonfort S, Candanedo F, González Vázquez M, Chavez Ocaña S, Jiménez Villanueva X, et al. Elevated concentration of microvesicles isolated from peripheral blood in breast cancer patients. Arch Med Res. 2013;44:208-14 pubmed publisher
  45. Marks M, Heijnen H, Raposo G. Lysosome-related organelles: unusual compartments become mainstream. Curr Opin Cell Biol. 2013;25:495-505 pubmed publisher
  46. Gibeaux R, Hoepfner D, Schlatter I, Antony C, Philippsen P. Organization of organelles within hyphae of Ashbya gossypii revealed by electron tomography. Eukaryot Cell. 2013;12:1423-32 pubmed publisher
    ..Finally, coated and uncoated vesicles with approximately 40-nm diameters show a polarized distribution toward the hyphal tip with the coated vesicles preferentially localizing at the hyphal periphery. ..
  47. Parkinson K, Baines A, Keller T, Gruenheit N, Bragg L, North R, et al. Calcium-dependent regulation of Rab activation and vesicle fusion by an intracellular P2X ion channel. Nat Cell Biol. 2014;16:87-98 pubmed publisher
    ..These findings suggest that P2XA activation results in vacuolar calcium release, which triggers activation of CnrF Rab GAP activity and subsequent downregulation of Rab11a to allow vacuole fusion...
  48. Rybak K, Steiner A, Synek L, Klaeger S, Kulich I, Facher E, et al. Plant cytokinesis is orchestrated by the sequential action of the TRAPPII and exocyst tethering complexes. Dev Cell. 2014;29:607-620 pubmed publisher
    ..We show that the two tethering complexes physically interact and propose that their coordinated action may orchestrate not only plant but also animal cytokinesis...
  49. Hosseini Beheshti E, Pham S, Adomat H, Li N, Tomlinson Guns E. Exosomes as biomarker enriched microvesicles: characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes. Mol Cell Proteomics. 2012;11:863-85 pubmed
    ..Our comprehensive proteomic and lipidomic analysis of prostate derived exosomes could provide insight for future work on both biomarker and therapeutic targets for the treatment of prostate cancer...
  50. Walmsley S, Freund D, Curthoys N. Proteomic profiling of the effect of metabolic acidosis on the apical membrane of the proximal convoluted tubule. Am J Physiol Renal Physiol. 2012;302:F1465-77 pubmed publisher
    ..Western blot analysis and accurate mass and time analyses were used to validate the spectral counting...
  51. Stockert J, Blazquez Castro A, Cañete M, Horobin R, Villanueva A. MTT assay for cell viability: Intracellular localization of the formazan product is in lipid droplets. Acta Histochem. 2012;114:785-96 pubmed publisher
    ..These predictions were in agreement with experimental observations on the accumulation of MTT formazan product in lipid droplets...
  52. Lu N, Zhou Z. Membrane trafficking and phagosome maturation during the clearance of apoptotic cells. Int Rev Cell Mol Biol. 2012;293:269-309 pubmed publisher
    ..Here, we discuss these exciting new findings, which have significantly deepened and broadened our understanding of the mechanisms that regulate the interaction between intracellular organelles and phagosomes...
  53. Kwong C, Gilman Sachs A, Beaman K. Tumor-associated a2 vacuolar ATPase acts as a key mediator of cancer-related inflammation by inducing pro-tumorigenic properties in monocytes. J Immunol. 2011;186:1781-9 pubmed publisher
    ..These findings describe a mechanism by which tumor cells affect the maturation of TAMs via a nontraditional cytokine-like signal, the a2NTD peptide...
  54. Hong S, So J, Lee J, Min K, Son H, Park C, et al. Functional analyses of two syntaxin-like SNARE genes, GzSYN1 and GzSYN2, in the ascomycete Gibberella zeae. Fungal Genet Biol. 2010;47:364-72 pubmed publisher
    ..These results suggest that syntaxins have key roles in fungal development and virulence in G. zeae...
  55. Tworzydlo W, Kloc M, Bilinski S. Female germline stem cell niches of earwigs are structurally simple and different from those of Drosophila melanogaster. J Morphol. 2010;271:634-40 pubmed publisher
    ..We also show that between somatic cells of earwig niche argosome-like vesicles and cytoneme-like extensions are present...
  56. Esseling Ozdoba A, Kik R, Van Lammeren A, Kleijn J, Emons A. Flexibility contra stiffness: the phragmoplast as a physical barrier for beads but not for vesicles. Plant Physiol. 2010;152:1065-72 pubmed publisher
    ..We conclude that stiffness is a parameter for vesicle transit through the phragmoplast and discuss that cytoskeleton configurations can physically block such transit...
  57. Fortini M. Notch signaling: the core pathway and its posttranslational regulation. Dev Cell. 2009;16:633-47 pubmed publisher
    ..This review describes the core developmental logic of Notch signaling and how regulatory mechanisms tailor Notch pathway outputs to specific developmental scenarios...
  58. Kadiu I, Narayanasamy P, Dash P, Zhang W, Gendelman H. Biochemical and biologic characterization of exosomes and microvesicles as facilitators of HIV-1 infection in macrophages. J Immunol. 2012;189:744-54 pubmed publisher
    ..HIV-1 containing exosomes readily completed its life cycle in human monocyte-derived macrophages but not in CD4(-) cells. The data support a significant role for exosomes as facilitators of viral infection...
  59. Leitch V, Dwivedi P, Anderson P, Powell B. Retinol-binding protein 4 downregulation during osteogenesis and its localization to non-endocytic vesicles in human cranial suture mesenchymal cells suggest a novel tissue function. Histochem Cell Biol. 2013;139:75-87 pubmed publisher
    ..a panel of antibody markers of cytoplasmic organelles demonstrated that RBP4 was present in several hundred cytoplasmic vesicles of about 300 nm in diameter which, in large part, were conspicuously distinct from the ER, the Golgi and ..
  60. Lige B, Romano J, Sampels V, Sonda S, Joiner K, Coppens I. Introduction of caveolae structural proteins into the protozoan Toxoplasma results in the formation of heterologous caveolae but not caveolar endocytosis. PLoS ONE. 2012;7:e51773 pubmed publisher
    ..This suggests a synergistic activity of caveolin-1 and cavin-1 in the morphogenesis and remodeling of membranes, as illustrated for Toxoplasma...
  61. Zhou Q, Souba W, Croce C, Verne G. MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome. Gut. 2010;59:775-84 pubmed publisher
    ..Our goal was to evaluate the expression of glutamine synthetase and its complementary miRNA in blood microvesicles and gut tissues of IBS patients with increased intestinal membrane permeability...
  62. Hagenmueller M, Riffel J, Bernhold E, Fan J, Katus H, Hardt S. Dapper-1 is essential for Wnt5a induced cardiomyocyte hypertrophy by regulating the Wnt/PCP pathway. FEBS Lett. 2014;588:2230-7 pubmed publisher
    ..Depletion of Dpr1 inhibits non-canonical Wnt signaling induced cardiomyocyte hypertrophy by blocking Wnt/PCP signaling. ..