intranuclear space

Summary

Summary: The area within the CELL NUCLEUS.

Top Publications

  1. Handwerger K, Gall J. Subnuclear organelles: new insights into form and function. Trends Cell Biol. 2006;16:19-26 pubmed
    ..We discuss how these findings impact our understanding of the guiding principles of nuclear organization and various types of human disease...
  2. Schmidt U, Richter K, Berger A, Lichter P. In vivo BiFC analysis of Y14 and NXF1 mRNA export complexes: preferential localization within and around SC35 domains. J Cell Biol. 2006;172:373-81 pubmed
    ..These results suggest that a fraction of RNA, which remains in the nucleus for several hours despite its association with splicing and export proteins, accumulates in speckles because of an ATP-dependent mechanism...
  3. Duan Z, Andronescu M, Schutz K, McIlwain S, Kim Y, Lee C, et al. A three-dimensional model of the yeast genome. Nature. 2010;465:363-7 pubmed publisher
    ..Finally, we constructed a three-dimensional model of the yeast genome. Our findings provide a glimpse of the interface between the form and function of a eukaryotic genome...
  4. Fraser P, Bickmore W. Nuclear organization of the genome and the potential for gene regulation. Nature. 2007;447:413-7 pubmed
    ..A crucial unresolved issue is the extent to which this organization affects gene function, rather than just reflecting it...
  5. Sleeman J. A regulatory role for CRM1 in the multi-directional trafficking of splicing snRNPs in the mammalian nucleus. J Cell Sci. 2007;120:1540-50 pubmed
    ..Its role in snRNP trafficking, however, appears to be distinct from its previously identified role in small nucleolar RNP (snoRNP) maturation...
  6. Tsai R, McKay R. A multistep, GTP-driven mechanism controlling the dynamic cycling of nucleostemin. J Cell Biol. 2005;168:179-84 pubmed
    ..We propose that a rapid nucleostemin cycle is designed to translate extra- and intra-cellular signals into the amount of nucleostemin in the nucleolus in a bidirectional and fast manner...
  7. Agarwal S, van Cappellen W, Guénolé A, Eppink B, Linsen S, Meijering E, et al. ATP-dependent and independent functions of Rad54 in genome maintenance. J Cell Biol. 2011;192:735-50 pubmed publisher
    ..Finally, we show that ATP hydrolysis by Rad54 is required for the redistribution of DSB repair sites within the nucleus. ..
  8. Bolhy S, Bouhlel I, Dultz E, Nayak T, Zuccolo M, Gatti X, et al. A Nup133-dependent NPC-anchored network tethers centrosomes to the nuclear envelope in prophase. J Cell Biol. 2011;192:855-71 pubmed publisher
    ..Finally, our study reveals that tethering of centrosomes to the nuclear surface at the G2/M transition contributes, along with other cellular mechanisms, to early stages of bipolar spindle assembly...
  9. Ghule P, Dominski Z, Yang X, Marzluff W, Becker K, Harper J, et al. Staged assembly of histone gene expression machinery at subnuclear foci in the abbreviated cell cycle of human embryonic stem cells. Proc Natl Acad Sci U S A. 2008;105:16964-9 pubmed publisher
    ..These temporal differences in the formation of histone locus bodies suggest that the G(1) phase of the cell cycle in hES cells is abbreviated in part by contraction of late G(1). ..

More Information

Publications85

  1. Gangwani L. Deficiency of the zinc finger protein ZPR1 causes defects in transcription and cell cycle progression. J Biol Chem. 2006;281:40330-40 pubmed
    ..These changes in subnuclear architecture and cell cycle progression may be caused by transcriptional defects in ZPR1-deficient cells, including decreased histone gene expression. ..
  2. Zaidi S, Medina R, Pockwinse S, Bakshi R, Kota K, Ali S, et al. Subnuclear localization and intranuclear trafficking of transcription factors. Methods Mol Biol. 2010;647:77-93 pubmed publisher
    ..Here we provide methodologies to characterize nuclear organization of regulatory machinery by in situ immunofluorescence microscopy. ..
  3. Wang S, Liu S. Protein Sub-Nuclear Localization Based on Effective Fusion Representations and Dimension Reduction Algorithm LDA. Int J Mol Sci. 2015;16:30343-61 pubmed publisher
  4. LI Y, Macnaughton T, Gao L, Lai M. RNA-templated replication of hepatitis delta virus: genomic and antigenomic RNAs associate with different nuclear bodies. J Virol. 2006;80:6478-86 pubmed
    ..These findings provide additional evidence that HDV RNA synthesis occurs in the Pol I and Pol II transcription machineries, thus extending the capability of the cellular DNA-dependent RNA polymerases to utilizing RNA as templates. ..
  5. Balzano Q. Comment on "Theoretical evaluation of dielectric absorption of microwave energy at the scale of nucleic acids". Bioelectromagnetics. 2005;26:79; author reply 80 pubmed
  6. Shin J, Wang S, Deng W, Wu J, Gao J, Zhong X. Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function. Proc Natl Acad Sci U S A. 2014;111:E776-83 pubmed publisher
    ..Our findings define an essential role of mTORC1 to direct iNKT-cell lineage development and effector function. ..
  7. Liu W, Fan Z, Han Y, Zhang D, Li J, Wang H. Intranuclear localization of apoptosis-inducing factor and endonuclease G involves in peroxynitrite-induced apoptosis of spiral ganglion neurons. Neurol Res. 2012;34:915-22 pubmed publisher
    ..These data indicate that ONOO(-) can trigger caspase-independent apoptosis in SGNs associated with mitochondrial AIF and Endo G intranuclear localization. ..
  8. Meng L, Yasumoto H, Tsai R. Multiple controls regulate nucleostemin partitioning between nucleolus and nucleoplasm. J Cell Sci. 2006;119:5124-36 pubmed
    ..Our work reveals that the partitioning of nucleostemin employs complex mechanisms involving both nucleolar and nucleoplasmic components, and provides insight into the post-translational regulation of its activity. ..
  9. Petrova N, Iarovaia O, Verbovoy V, Razin S. Specific radial positions of centromeres of human chromosomes X, 1, and 19 remain unchanged in chromatin-depleted nuclei of primary human fibroblasts: evidence for the organizing role of the nuclear matrix. J Cell Biochem. 2005;96:850-7 pubmed
    ..These results strongly suggest that the characteristic organization of interphase chromosomes is supported by the proteinous nuclear matrix and is not maintained by simple repulsing of negatively charged chromosomes. ..
  10. Sengupta K, Upender M, Barenboim Stapleton L, Nguyen Q, Wincovitch S, Garfield S, et al. Artificially introduced aneuploid chromosomes assume a conserved position in colon cancer cells. PLoS ONE. 2007;2:e199 pubmed
    ..Whether the nuclear localization determines or is determined by the transcriptional activity of resident genes has yet to be ascertained. ..
  11. Laser H, Conforti L, Morreale G, Mack T, Heyer M, Haley J, et al. The slow Wallerian degeneration protein, WldS, binds directly to VCP/p97 and partially redistributes it within the nucleus. Mol Biol Cell. 2006;17:1075-84 pubmed
    ..We conclude that N-terminal sequences of Wld(S) protein influence the intranuclear location of both ubiquitin proteasome and NAD(+) synthesis machinery and that an evolutionary recent sequence mediates binding of mammalian Ube4b to VCP. ..
  12. Daga R, Chang F. Dynamic positioning of the fission yeast cell division plane. Proc Natl Acad Sci U S A. 2005;102:8228-32 pubmed
    ..Furthermore, movement of ring fragments together minimizes formation of multiple division sites. These dynamic mechanisms of ring positioning provide a robust coordination of nuclear and cell division. ..
  13. Cleary J, Sitwala K, Khodadoust M, Kwok R, Mor Vaknin N, Cebrat M, et al. p300/CBP-associated factor drives DEK into interchromatin granule clusters. J Biol Chem. 2005;280:31760-7 pubmed
    ..These findings also suggest that DEK-associated malignancies and autoimmune diseases might be amenable to treatment with agents that alter acetylation. ..
  14. Passon D, Lee M, Rackham O, Stanley W, Sadowska A, Filipovska A, et al. Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation. Proc Natl Acad Sci U S A. 2012;109:4846-50 pubmed publisher
    ..These results suggest that paraspeckles may potentially form through self-association of DBHS dimers into higher-order structures. ..
  15. Tripathi V, Ellis J, Shen Z, Song D, Pan Q, Watt A, et al. The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation. Mol Cell. 2010;39:925-38 pubmed publisher
    ..Taken together, our results suggest that MALAT1 regulates AS by modulating the levels of active SR proteins. Our results further highlight the role for an nrRNA in the regulation of gene expression. ..
  16. Lermontova I, Schubert V, Börnke F, Macas J, Schubert I. Arabidopsis CBF5 interacts with the H/ACA snoRNP assembly factor NAF1. Plant Mol Biol. 2007;65:615-26 pubmed
    ..The homologous yeast protein has been shown to contribute to RNA pseudouridinylation. Thus, AtCBF5 might have an essential function in RNA processing rather than being a kinetochore protein. ..
  17. Rios Doria J, Melendez J, Monteiro A. Three-color intranuclear staining for measuring mitosis and apoptosis in cells transfected with a GFP-tagged histone. Biotech Histochem. 2010;85:127-31 pubmed publisher
    ..We also demonstrate another application of this method for simultaneous detection of a GFP-tagged histone, DNA content, and cleaved caspase-3. ..
  18. Draskovic I, Arnoult N, Steiner V, Bacchetti S, Lomonte P, Londono Vallejo A. Probing PML body function in ALT cells reveals spatiotemporal requirements for telomere recombination. Proc Natl Acad Sci U S A. 2009;106:15726-31 pubmed publisher
  19. Hancock R. Internal organisation of the nucleus: assembly of compartments by macromolecular crowding and the nuclear matrix model. Biol Cell. 2004;96:595-601 pubmed
    ..The model that they play a role in compartmentalisation of the nucleus is generally consistent with the properties of compartments, including their spherical or quasispherical form and their dynamic and mobile nature...
  20. Garner M, Gardiner C, Wellehan J, Johnson A, McNamara T, Linn M, et al. Intranuclear coccidiosis in tortoises: nine cases. Vet Pathol. 2006;43:311-20 pubmed
    ..Intranuclear coccidiosis was associated with variable degrees of inflammation in all cases, was considered the cause of death in six tortoises, and was a substantial contributing factor to the cause of death in two tortoises. ..
  21. Vanderstraeten J, Vander Vorst A. Theoretical evaluation of dielectric absorption of microwave energy at the scale of nucleic acids. Bioelectromagnetics. 2004;25:380-9 pubmed
    ..Nevertheless, the question arises of a possible biological relevance of nonnegligible and preferential heat production at the location of the cell nucleus and of the NA molecules...
  22. Ghule P, Dominski Z, Lian J, Stein J, Van Wijnen A, Stein G. The subnuclear organization of histone gene regulatory proteins and 3' end processing factors of normal somatic and embryonic stem cells is compromised in selected human cancer cell types. J Cell Physiol. 2009;220:129-35 pubmed publisher
  23. Hodges R, Laffafian I, Hallett M. Intranuclear Ca2+ signals within individual nuclear lobes of neutrophils. Cell Biol Int. 2003;27:395-402 pubmed
  24. Dieker J, Iglesias Guimarais V, Decossas M, Stevenin J, van der Vlag J, Yuste V, et al. Early apoptotic reorganization of spliceosomal proteins involves caspases, CAD and rearrangement of NuMA. Traffic. 2012;13:257-72 pubmed publisher
    ..In conclusion, we show here that the apoptotic rearrangement of IGCs, the nuclear matrix and chromatin are closely associated, occur in defined stages and depend on the activity of protein phosphatases, caspases and CAD...
  25. Kearse M, Ireland J, Prem S, Chen A, Ware V. RpL22e, but not RpL22e-like-PA, is SUMOylated and localizes to the nucleoplasm of Drosophila meiotic spermatocytes. Nucleus. 2013;4:241-58 pubmed publisher
    ..Overall, these data suggest distinct male germline roles for RpL22e and RpL22e-like-PA. ..
  26. Bryantsev A, Chechenova M, Shelden E. Recruitment of phosphorylated small heat shock protein Hsp27 to nuclear speckles without stress. Exp Cell Res. 2007;313:195-209 pubmed
    ..These data demonstrate that phosphorylation, but not stress, mediates Hsp27 recruitment to an RNAse soluble fraction of nuclear speckles and support a site-specific role for Hsp27 within the nucleus...
  27. Voss T, Demarco I, Booker C, Day R. Quantitative methods to analyze subnuclear protein organization in cell populations with varying degrees of protein expression. J Biomed Opt. 2005;10:024011 pubmed
    ..This integrated quantitative image analysis method will allow the rigorous comparison of different experimental cell populations that express variable levels of FP fusion proteins...
  28. Melko M, Douguet D, Bensaid M, Zongaro S, Verheggen C, Gecz J, et al. Functional characterization of the AFF (AF4/FMR2) family of RNA-binding proteins: insights into the molecular pathology of FRAXE intellectual disability. Hum Mol Genet. 2011;20:1873-85 pubmed publisher
    ..It is possible that other members of the AFF family compensate for the loss of AFF2/FMR2 activity and as such explain the relatively mild to borderline phenotype observed in FRAXE patients...
  29. Cornelissen B, Kersemans V, McLarty K, Tran L, Vallis K, Reilly R. In vivo monitoring of intranuclear p27(kip1) protein expression in breast cancer cells during trastuzumab (Herceptin) therapy. Nucl Med Biol. 2009;36:811-9 pubmed publisher
    ..The aim of this study was to develop a radioimmunoconjugate (RIC) to monitor trastuzumab-induced p27(kip1) protein up-regulation in vivo...
  30. Rajapakse I, Groudine M. On emerging nuclear order. J Cell Biol. 2011;192:711-21 pubmed publisher
    ..These approaches will help uncover how seemingly separate nuclear processes may be coupled and aid in the effort to understand the role of nuclear organization in development and disease...
  31. Ji J, Lee R, Vergnes L, Fong L, Stewart C, Reue K, et al. Cell nuclei spin in the absence of lamin b1. J Biol Chem. 2007;282:20015-26 pubmed
    ..These findings demonstrate that lamin B1 serves a fundamental role within the nuclear envelope: anchoring the nucleus to the cytoskeleton...
  32. Stentiford G, Bateman K, Longshaw M, Feist S. Enterospora canceri n. gen., n. sp., intranuclear within the hepatopancreatocytes of the European edible crab Cancer pagurus. Dis Aquat Organ. 2007;75:61-72 pubmed
    ..Molecular taxonomic work is now required, comparing Enterospora to Enterocytozoon and Nucleospora, the 2 other genera within the Enterocytozoonidae...
  33. Gatza M, Marriott S. Genotoxic stress and cellular stress alter the subcellular distribution of human T-cell leukemia virus type 1 tax through a CRM1-dependent mechanism. J Virol. 2006;80:6657-68 pubmed
    ..Changes in Tax distribution and interacting partners are likely to affect cellular processes that regulate cellular transformation...
  34. Luco R, Maestro M, Sadoni N, Zink D, Ferrer J. Targeted deficiency of the transcriptional activator Hnf1alpha alters subnuclear positioning of its genomic targets. PLoS Genet. 2008;4:e1000079 pubmed publisher
    ..We have also revealed a defect in subnuclear gene positioning in a model of a human transcription factor disease...
  35. Dvorak Z, Modriansky M, Ulrichova J, Maurel P, Vilarem M, Pascussi J. Disruption of microtubules leads to glucocorticoid receptor degradation in HeLa cell line. Cell Signal. 2005;17:187-96 pubmed
    ..Similarly, another hGR functional antagonist, nuclear factor kappa beta (NFkappaB), did not play any role in the degradation process...
  36. Venkatram S, Tasto J, Feoktistova A, Jennings J, Link A, Gould K. Identification and characterization of two novel proteins affecting fission yeast gamma-tubulin complex function. Mol Biol Cell. 2004;15:2287-301 pubmed
    ..This study expands the known roles of gamma-tubulin complex components in organizing different types of microtubule structures in S. pombe...
  37. Gherghiceanu M, Popescu L. Interstitial Cajal-like cells (ICLC) in human resting mammary gland stroma. Transmission electron microscope (TEM) identification. J Cell Mol Med. 2005;9:893-910 pubmed
    ..juxta- and/or paracrine secretion, uncommited progenitor cells, immunological surveillance, intercellular signaling, etc.) are essential for the epithelium/stroma equilibrium in the mammary gland under normal or pathological conditions...
  38. Zhao R, Sun B, Liu T, Liu Y, Zhou S, Zuo A, et al. Optimize nuclear localization and intra-nucleus disassociation of the exogene for facilitating transfection efficacy of the chitosan. Int J Pharm. 2011;413:254-9 pubmed publisher
    ..In conclusion, nucleus localization and unpacking from the delivery vector are both critical factors in influencing exogene expression, and pNNS modification is valuable in improving transfection efficacy of the chitosan...
  39. Boyd M, Vlatkovic N, Rubbi C. The nucleolus directly regulates p53 export and degradation. J Cell Biol. 2011;194:689-703 pubmed publisher
    ..In addition, our results indicate that p53 is exported by two pathways: one stress sensitive and one stress insensitive, the latter being regulated by activities present in the nucleolus...
  40. Michaud S, Lavoie S, Guimond M, Tanguay R. The nuclear localization of Drosophila Hsp27 is dependent on a monopartite arginine-rich NLS and is uncoupled from its association to nuclear speckles. Biochim Biophys Acta. 2008;1783:1200-10 pubmed publisher
    ..The present study identifies two distinct sets of sequences respectively mediating the nuclear import of Hsp27 and its association to nuclear speckles. These two phenomena are uncoupled and can be separately abrogated...
  41. Navarro M, Peñate X, Landeira D. Nuclear architecture underlying gene expression in Trypanosoma brucei. Trends Microbiol. 2007;15:263-70 pubmed
    ..Here, we discuss recent advances in understanding the role of chromosomal nuclear positioning in the regulation of gene expression in T. brucei...
  42. Unneberg P, Claverie J. Tentative mapping of transcription-induced interchromosomal interaction using chimeric EST and mRNA data. PLoS ONE. 2007;2:e254 pubmed
    ..Due to their higher quality, the mRNA findings are of particular interest and we hope that they may serve as food for thought for specialists in diverse areas of molecular biology...
  43. Chung I, Leonhardt H, Rippe K. De novo assembly of a PML nuclear subcompartment occurs through multiple pathways and induces telomere elongation. J Cell Sci. 2011;124:3603-18 pubmed publisher
    ..X phosphorylation, and an increase of the telomere repeat length. These activities were absent after recruitment of the APB factors to a pericentric locus and establish APBs as functional intermediates of the ALT pathway...
  44. Agostinho M, Rino J, Braga J, Ferreira F, Steffensen S, Ferreira J. Human topoisomerase IIalpha: targeting to subchromosomal sites of activity during interphase and mitosis. Mol Biol Cell. 2004;15:2388-400 pubmed
    ..Together, our data implicate several previously unsuspected activities in the partitioning of the enzyme between sites of activity and putative depots...
  45. Kindsmüller K, Groitl P, Härtl B, Blanchette P, Hauber J, Dobner T. Intranuclear targeting and nuclear export of the adenovirus E1B-55K protein are regulated by SUMO1 conjugation. Proc Natl Acad Sci U S A. 2007;104:6684-9 pubmed
  46. Iyer K, Maharana S, Gupta S, Libchaber A, Tlusty T, Shivashankar G. Modeling and experimental methods to probe the link between global transcription and spatial organization of chromosomes. PLoS ONE. 2012;7:e46628 pubmed publisher
    ..Taken together, our methods highlight the functional coupling between topology of chromosomes and their respective gene expression patterns...
  47. Harmon J, Bogdani M, Parazzoli S, Mak S, Oseid E, Berghmans M, et al. beta-Cell-specific overexpression of glutathione peroxidase preserves intranuclear MafA and reverses diabetes in db/db mice. Endocrinology. 2009;150:4855-62 pubmed publisher
    ..These studies demonstrate that enhancement of intrinsic antioxidant defenses of the beta-cell protects it against deterioration during hyperglycemia...
  48. Aumiller W, Davis B, Keating C. Phase separation as a possible means of nuclear compartmentalization. Int Rev Cell Mol Biol. 2014;307:109-49 pubmed publisher
  49. Lee S, Chang S, Kuo W, Ying T, Kuo W, Li P, et al. Role of mitogen-activated protein kinase kinase in Porphyromonas gingivalis-induced myocardial cell hypertrophy and apoptosis. Eur J Oral Sci. 2006;114:154-9 pubmed
    ..gingivalis medium, were all significantly reduced after pre-administration of U0126. The results suggest that P. gingivalis-secreted factors may initiate MEK/ERK signal pathways and lead to myocardial cell hypertrophy and apoptosis...
  50. Yang Y, Candelario Jalil E, Thompson J, Cuadrado E, Estrada E, Rosell A, et al. Increased intranuclear matrix metalloproteinase activity in neurons interferes with oxidative DNA repair in focal cerebral ischemia. J Neurochem. 2010;112:134-49 pubmed publisher
    ..Our data suggest that intranuclear MMP activity cleaves PARP-1 and XRCC1, interfering with oxidative DNA repair. This novel role for MMPs could contribute to neuronal apoptosis in ischemic injuries...
  51. Jaé N, Wang P, Gu T, Hühn M, Palfi Z, Urlaub H, et al. Essential role of a trypanosome U4-specific Sm core protein in small nuclear ribonucleoprotein assembly and splicing. Eukaryot Cell. 2010;9:379-86 pubmed publisher
    ..Together, these data indicate that the assembly of the U4-specific Sm core provides an essential step in U4/U6 di-snRNP biogenesis and splicing in trypanosomes...
  52. Pekovic V, Harborth J, Broers J, Ramaekers F, van Engelen B, Lammens M, et al. Nucleoplasmic LAP2alpha-lamin A complexes are required to maintain a proliferative state in human fibroblasts. J Cell Biol. 2007;176:163-72 pubmed
    ..Our results suggest that LAP2alpha and lamin A/C are involved in controlling Rb localization and phosphorylation, and a lack or mislocalization of either protein leads to cell cycle arrest in HDFs...
  53. Biamonti G, Vourc h C. Nuclear stress bodies. Cold Spring Harb Perspect Biol. 2010;2:a000695 pubmed publisher
    ..The analysis of these atypical and intriguing structures uncovers new facets of the relationship between nuclear organization and nuclear function...
  54. Wiesmeijer K, Krouwels I, Tanke H, Dirks R. Chromatin movement visualized with photoactivable GFP-labeled histone H4. Differentiation. 2008;76:83-90 pubmed
    ..The results reveal a constrained chromatin motion, which is not affected by transcriptional inhibition, and suggests an intimate interaction of chromatin with speckles...
  55. Wen X, Lei Y, Zhou Y, Okamoto C, Snead M, Paine M. Structural organization and cellular localization of tuftelin-interacting protein 11 (TFIP11). Cell Mol Life Sci. 2005;62:1038-46 pubmed
    ..The TFIP body may therefore represent a new subnuclear storage compartment for splicing components...
  56. Parada L, Roix J, Misteli T. An uncertainty principle in chromosome positioning. Trends Cell Biol. 2003;13:393-6 pubmed
    ..Two reports have applied in vivo microscopy to track chromosomes in space and time. The results highlight the inherently imperfect and probabilistic nature of chromosome positioning in the cell nucleus...
  57. Ebina M, Tsuruta F, Katoh M, Kigoshi Y, Someya A, Chiba T. Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear localization through Nedd8 modification. PLoS ONE. 2013;8:e65285 pubmed publisher
    ..Our findings provide a novel link between oncogenic stress and p53 pathway and may shed light on the protective mechanism against cancer...
  58. Misteli T. Going in GTP cycles in the nucleolus. J Cell Biol. 2005;168:177-8 pubmed
    ..The uncovered mechanism also implies that localization is determined by increased retention rather than directed targeting...
  59. Popovici C, Fallet M, Marguet D, Birnbaum D, Roubin R. Intracellular trafficking of LET-756, a fibroblast growth factor of C. elegans, is controlled by a balance of export and nuclear signals. Exp Cell Res. 2006;312:1484-95 pubmed
    ..We propose that LET-756 exerts its functions through a balance between secreted and nuclear forms due to two opposite addressing signals, (i) synergy of several NLS and (ii) attenuated secretion signal...
  60. Florin L, Becker K, Lambert C, Nowak T, Sapp C, Strand D, et al. Identification of a dynein interacting domain in the papillomavirus minor capsid protein l2. J Virol. 2006;80:6691-6 pubmed
  61. Swiatek P, Jaglarz M. snRNPs are present in the karyosome capsule in the weevil germinal vesicle. Tissue Cell. 2004;36:253-62 pubmed
    ..We suggest that the karyosome capsule is a storage site for small nuclear ribonucleoprotein particles, which may be used during early embryonic development...
  62. Sarafidou T, Kahl C, Martinez Garay I, Mangelsdorf M, Gesk S, Baker E, et al. Folate-sensitive fragile site FRA10A is due to an expansion of a CGG repeat in a novel gene, FRA10AC1, encoding a nuclear protein. Genomics. 2004;84:69-81 pubmed
    ..Our data also suggest that in the heterozygous state FRA10A is likely a benign folate-sensitive fragile site...
  63. Khalil A, Grant J, Caddle L, Atzema E, Mills K, Arneodo A. Chromosome territories have a highly nonspherical morphology and nonrandom positioning. Chromosome Res. 2007;15:899-916 pubmed
    ..We discuss potential relationships between morphology, positioning, chromosomal function, and instability...
  64. Li C, Henderson I, Song L, Fedoroff N, Lagrange T, Jacobsen S. Dynamic regulation of ARGONAUTE4 within multiple nuclear bodies in Arabidopsis thaliana. PLoS Genet. 2008;4:e27 pubmed publisher
  65. Paeschke K, Juranek S, Rhodes D, Lipps H. Cell cycle-dependent regulation of telomere tethering in the nucleus. Chromosome Res. 2008;16:721-8 pubmed publisher
    ..Our data can be incorporated into a mechanistic model for the regulation of telomere conformation and localization throughout the cell cycle...
  66. Niedojadło J, Górska Brylass A. New type of snRNP containing nuclear bodies in plant cells. Biol Cell. 2003;95:303-10 pubmed
  67. Shen H, Chou K. Predicting protein subnuclear location with optimized evidence-theoretic K-nearest classifier and pseudo amino acid composition. Biochem Biophys Res Commun. 2005;337:752-6 pubmed
    ..The OET-KNN classifier will be available at www.pami.sjtu.edu.cn/people/hbshen...
  68. Schütz W, Alsheimer M, Ollinger R, Benavente R. Nuclear envelope remodeling during mouse spermiogenesis: postmeiotic expression and redistribution of germline lamin B3. Exp Cell Res. 2005;307:285-91 pubmed
    ..Lamin B3 is the first example of a mammalian lamin that is selectively expressed during postmeiotic stages of spermatogenesis...
  69. Dahmcke C, Büchmann Møller S, Jensen N, Mitchelmore C. Altered splicing in exon 8 of the DNA replication factor CIZ1 affects subnuclear distribution and is associated with Alzheimer's disease. Mol Cell Neurosci. 2008;38:589-94 pubmed publisher
    ..We demonstrate for the first time that a minimal 28 amino acid sequence within this region is required for CIZ1 to associate with the nuclear matrix and to form nuclear foci...
  70. Bonnet A, Randrianarison Huetz V, Nzounza P, Nedelec M, Chazal M, Waast L, et al. Low nuclear body formation and tax SUMOylation do not prevent NF-kappaB promoter activation. Retrovirology. 2012;9:77 pubmed publisher
  71. Chen M. Phytochrome nuclear body: an emerging model to study interphase nuclear dynamics and signaling. Curr Opin Plant Biol. 2008;11:503-8 pubmed publisher
  72. Carrettiero D, Almeida R, Fior Chadi D. Adenosine modulates alpha2-adrenergic receptors within specific subnuclei of the nucleus tractus solitarius in normotensive and spontaneously hypertensive rats. Hypertens Res. 2008;31:2177-86 pubmed publisher
    ..This may be important in understanding the complex autonomic response induced by adenosine within the NTS. In addition, changes in interactions between receptors might be relevant to understanding the development of hypertension...
  73. Jakočiūnas T, Domange Jordö M, Aït Mebarek M, Bünner C, Verhein Hansen J, Oddershede L, et al. Subnuclear relocalization and silencing of a chromosomal region by an ectopic ribosomal DNA repeat. Proc Natl Acad Sci U S A. 2013;110:E4465-73 pubmed publisher
  74. Doucas V. DNA and RNA viruses target a common subnuclear domain: many images to one structure?. Nat Rev Microbiol. 2006;4:c1 pubmed
  75. Zimmer C, Fabre E. Principles of chromosomal organization: lessons from yeast. J Cell Biol. 2011;192:723-33 pubmed publisher
    ..The dynamic organization of the yeast genome during interphase argues for both the physical properties of the chromatin fiber and specific molecular interactions as drivers of nuclear order...
  76. Sunn K, Eisman J, Gardiner E, Jans D. FRAP analysis of nucleocytoplasmic dynamics of the vitamin D receptor splice variant VDRB1: preferential targeting to nuclear speckles. Biochem J. 2005;388:509-14 pubmed
    ..The results are consistent with the existence of specialized pathways to target proteins to nuclear subdomains...