cell nucleus structures


Summary: Structures that are part of or contained in the CELL NUCLEUS.

Top Publications

  1. Dundr M, Misteli T. Biogenesis of nuclear bodies. Cold Spring Harb Perspect Biol. 2010;2:a000711 pubmed publisher
    ..The controlled biogenesis of nuclear bodies is essential for faithful maintenance of nuclear architecture during the cell cycle and is an important part of cellular responses to intra- and extracellular events. ..
  2. Bailey D, O Hare P. Herpes simplex virus 1 ICP0 co-localizes with a SUMO-specific protease. J Gen Virol. 2002;83:2951-64 pubmed
    ..The significance of these findings is discussed in relation to the function of ICP0...
  3. Holmberg C, Illman S, Kallio M, Mikhailov A, Sistonen L. Formation of nuclear HSF1 granules varies depending on stress stimuli. Cell Stress Chaperones. 2000;5:219-28 pubmed
    ..Our results suggest that, depending on the type of stress stimulus, the multiple events associated with HSF1 activation might be affected differently...
  4. Boisvert F, Kruhlak M, Box A, Hendzel M, Bazett Jones D. The transcription coactivator CBP is a dynamic component of the promyelocytic leukemia nuclear body. J Cell Biol. 2001;152:1099-106 pubmed
    ..Our results are consistent with CBP being a dynamic component of PML bodies and that the steady-state level in these structures can be modulated by Pml...
  5. Chen L, Carmichael G. Altered nuclear retention of mRNAs containing inverted repeats in human embryonic stem cells: functional role of a nuclear noncoding RNA. Mol Cell. 2009;35:467-78 pubmed publisher
    ..Taken together, these results assign a biological function to a large noncoding nuclear RNA in the regulation of mRNA export...
  6. Negorev D, Maul G. Cellular proteins localized at and interacting within ND10/PML nuclear bodies/PODs suggest functions of a nuclear depot. Oncogene. 2001;20:7234-42 pubmed
    ..These nuclear depot functions seem important as nuclear defense against viral attack and other external insults...
  7. Metz A, Soret J, Vourc h C, Tazi J, Jolly C. A key role for stress-induced satellite III transcripts in the relocalization of splicing factors into nuclear stress granules. J Cell Sci. 2004;117:4551-8 pubmed
    ..Altogether, these data highlight the central role for satellite III transcripts in the targeting and/or retention of splicing factors into the granules upon stress...
  8. Gonzalo S, Jaco I, Fraga M, Chen T, Li E, Esteller M, et al. DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nat Cell Biol. 2006;8:416-24 pubmed
    ..Together, these results demonstrate a previously unappreciated role for DNA methylation in maintaining telomere integrity...
  9. Naganuma T, Nakagawa S, Tanigawa A, Sasaki Y, Goshima N, Hirose T. Alternative 3'-end processing of long noncoding RNA initiates construction of nuclear paraspeckles. EMBO J. 2012;31:4020-34 pubmed publisher
    ..This HNRNPK function led to the preferential accumulation of NEAT1_2 and initiated paraspeckle construction with multiple PSPs...

More Information


  1. Cardinale S, Cisterna B, Bonetti P, Aringhieri C, Biggiogera M, Barabino S. Subnuclear localization and dynamics of the Pre-mRNA 3' end processing factor mammalian cleavage factor I 68-kDa subunit. Mol Biol Cell. 2007;18:1282-92 pubmed
    ..These findings suggest that paraspeckles are a functional compartment involved in RNA metabolism in the cell nucleus...
  2. Dellaire G, Ching R, Ahmed K, Jalali F, Tse K, Bristow R, et al. Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR. J Cell Biol. 2006;175:55-66 pubmed
    ..Therefore, an increase in PML NB number is an intrinsic element of the cellular response to DNA damage...
  3. Jolly C, Metz A, Govin J, Vigneron M, Turner B, Khochbin S, et al. Stress-induced transcription of satellite III repeats. J Cell Biol. 2004;164:25-33 pubmed
  4. Eskiw C, Dellaire G, Mymryk J, Bazett Jones D. Size, position and dynamic behavior of PML nuclear bodies following cell stress as a paradigm for supramolecular trafficking and assembly. J Cell Sci. 2003;116:4455-66 pubmed
    ..PML bodies may provide a useful paradigm for the dynamics and integrity of other supramolecular protein complexes involved in processes such as transcription, RNA processing DNA repair and replication...
  5. Best J, Ganiatsas S, Agarwal S, Changou A, Salomoni P, Shirihai O, et al. SUMO-1 protease-1 regulates gene transcription through PML. Mol Cell. 2002;10:843-55 pubmed
    ..SuPr-1 action on transcription was enhanced by PML, and SuPr-1 failed to activate transcription in PML-deficient fibroblasts. Our studies establish an important role for SUMO proteases in transcription...
  6. Adamson A, Kenney S. Epstein-barr virus immediate-early protein BZLF1 is SUMO-1 modified and disrupts promyelocytic leukemia bodies. J Virol. 2001;75:2388-99 pubmed
    ..These results suggest that disruption of PML bodies is important for efficient lytic replication of EBV. Furthermore, Z may potentially alter the function of a variety of cellular proteins by inhibiting SUMO-1 modification...
  7. Borden K. Pondering the promyelocytic leukemia protein (PML) puzzle: possible functions for PML nuclear bodies. Mol Cell Biol. 2002;22:5259-69 pubmed
  8. Bernardi R, Pandolfi P. Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies. Nat Rev Mol Cell Biol. 2007;8:1006-16 pubmed
    ..Recent data suggest that PML-NBs may be heterogeneous in composition, mobility and function...
  9. Zimowska G, Paddy M. Structures and dynamics of Drosophila Tpr inconsistent with a static, filamentous structure. Exp Cell Res. 2002;276:223-32 pubmed
  10. Everett R. DNA viruses and viral proteins that interact with PML nuclear bodies. Oncogene. 2001;20:7266-73 pubmed
    ..This article reviews the latest developments in the interactions between PML NBs and herpesviruses, adenoviruses and papovaviruses...
  11. Matera A, Izaguire Sierra M, Praveen K, Rajendra T. Nuclear bodies: random aggregates of sticky proteins or crucibles of macromolecular assembly?. Dev Cell. 2009;17:639-47 pubmed publisher
  12. Chiodi I, Corioni M, Giordano M, Valgardsdottir R, Ghigna C, Cobianchi F, et al. RNA recognition motif 2 directs the recruitment of SF2/ASF to nuclear stress bodies. Nucleic Acids Res. 2004;32:4127-36 pubmed
    ..Our analysis suggests that the recruitment of SF2/ASF to nSBs is mediated by a direct interaction with satellite III transcripts and points to the second RNA-binding domain of the protein as the major determinant of this interaction...
  13. Goldman R, Shumaker D, Erdos M, Eriksson M, Goldman A, Gordon L, et al. Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci U S A. 2004;101:8963-8 pubmed
  14. Valgardsdottir R, Chiodi I, Giordano M, Cobianchi F, Riva S, Biamonti G. Structural and functional characterization of noncoding repetitive RNAs transcribed in stressed human cells. Mol Biol Cell. 2005;16:2597-604 pubmed
    ..Thus, satellite III RNAs have a major role in the formation of nSBs. ..
  15. Shen T, Lin H, Scaglioni P, Yung T, Pandolfi P. The mechanisms of PML-nuclear body formation. Mol Cell. 2006;24:331-9 pubmed
  16. Spector D. SnapShot: Cellular bodies. Cell. 2006;127:1071 pubmed
  17. Everett R. Interactions between DNA viruses, ND10 and the DNA damage response. Cell Microbiol. 2006;8:365-74 pubmed
    ..Similarly, PML and DNA repair proteins are recruited to sites of DNA damage. The mechanisms by which these events might occur, and the implications for ND10 function in DNA virus infection and chromatin metabolism, are discussed...
  18. Park S, Hu X, Gupta P, Lin Y, Ha S, Wei L. SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells. Nat Struct Mol Biol. 2007;14:68-75 pubmed
  19. Takahashi Y, Lallemand Breitenbach V, Zhu J, De The H. PML nuclear bodies and apoptosis. Oncogene. 2004;23:2819-24 pubmed
    ..A variety of stress-related signalling pathways dramatically modulate the formation of PML NBs, which may provide a clue as to their physiological function...
  20. White A, Leslie M, Calvi B, Marzluff W, Duronio R. Developmental and cell cycle regulation of the Drosophila histone locus body. Mol Biol Cell. 2007;18:2491-502 pubmed
    ..HLB foci are present in histone deletion embryos, although the MPM-2 foci are smaller, and some Lsm11 foci are not associated with MPM-2 foci, suggesting that the histone locus is important for HLB integrity. ..
  21. Reymann J, Baddeley D, Gunkel M, Lemmer P, Stadter W, Jegou T, et al. High-precision structural analysis of subnuclear complexes in fixed and live cells via spatially modulated illumination (SMI) microscopy. Chromosome Res. 2008;16:367-82 pubmed publisher
    ..Furthermore, we have successfully implemented an optional optical configuration allowing the generation of high-resolution localization microscopy images of a nuclear pore complex distribution...
  22. Martin S, Failla A, Spöri U, Cremer C, Pombo A. Measuring the size of biological nanostructures with spatially modulated illumination microscopy. Mol Biol Cell. 2004;15:2449-55 pubmed
    ..The hyperphosphorylated form of polymerase II was found in structures with a diameter of approximately 70 nm, well below the 200-nm resolution limit of standard fluorescence microscopes...
  23. Lamond A, Spector D. Nuclear speckles: a model for nuclear organelles. Nat Rev Mol Cell Biol. 2003;4:605-12 pubmed
    ..Studies on the composition, structure and behaviour of speckles have provided a model for understanding the functional compartmentalization of the nucleus and the organization of the gene-expression machinery...
  24. Xie S, Martin S, Guillot P, Bentley D, Pombo A. Splicing speckles are not reservoirs of RNA polymerase II, but contain an inactive form, phosphorylated on serine2 residues of the C-terminal domain. Mol Biol Cell. 2006;17:1723-33 pubmed
    ..We find that paraspeckles are transcriptionally inactive but contain polymerase II, which remains stably associated upon transcriptional inhibition, when paraspeckles reorganize around nucleoli in the form of caps...
  25. White A, Burch B, Yang X, Gasdaska P, Dominski Z, Marzluff W, et al. Drosophila histone locus bodies form by hierarchical recruitment of components. J Cell Biol. 2011;193:677-94 pubmed publisher
  26. Wang I, Reddy N, Shen C. Higher order arrangement of the eukaryotic nuclear bodies. Proc Natl Acad Sci U S A. 2002;99:13583-8 pubmed
    ..Furthermore, TB sometimes appears to be the bridge of two or more of these other nuclear bodies. Our data suggest the existence of a hierarchy and possibly functional arrangement of the nuclear bodies within the eukaryotic nuclei...
  27. Sanchez Pulido L, Valencia A, Rojas A. Are promyelocytic leukaemia protein nuclear bodies a scaffold for caspase-2 programmed cell death?. Trends Biochem Sci. 2007;32:400-6 pubmed
    ..If verified experimentally, this discovery will suggest a mechanism by which caspase-2 could be recruited into the complex and ultimately lead to apoptosis. ..
  28. Sánchez Alvarez M, Goldstrohm A, Garcia Blanco M, Suñé C. Human transcription elongation factor CA150 localizes to splicing factor-rich nuclear speckles and assembles transcription and splicing components into complexes through its amino and carboxyl regions. Mol Cell Biol. 2006;26:4998-5014 pubmed
    ..Our results suggest that sequences located at both the amino and carboxyl regions of CA150 are required to assemble transcription/splicing complexes, which may be involved in the coupling of those processes. ..
  29. Kosta A, Thomopoulos G. Intranuclear virus-like particles of a Drosophila hybrid. J Submicrosc Cytol Pathol. 2002;34:177-86 pubmed
    ..mauritiana. There is the intriguing possibility that these VLPs are related to transposable elements and probably contribute to the speciation process, in an unknown, so far, manner. ..
  30. Wang I, Chang H, Shen C. Actin-based modeling of a transcriptionally competent nuclear substructure induced by transcription inhibition. Exp Cell Res. 2006;312:3796-807 pubmed
  31. Lafarga M, Berciano M, Pena E, Mayo I, Castaño J, Bohmann D, et al. Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome. Mol Biol Cell. 2002;13:2771-82 pubmed
    ..We propose that clastosomes are sites where proteolysis of a variety of protein substrates is taking place. ..
  32. Culjkovic B, Topisirovic I, Skrabanek L, Ruiz Gutierrez M, Borden K. eIF4E is a central node of an RNA regulon that governs cellular proliferation. J Cell Biol. 2006;175:415-26 pubmed
    ..Finally, the growth-suppressive promyelocytic leukemia protein (PML) inhibits this RNA regulon. These data provide novel perspectives into the proliferative and oncogenic properties of eIF4E. ..
  33. Deltour S, Pinte S, Guerardel C, Wasylyk B, Leprince D. The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif. Mol Cell Biol. 2002;22:4890-901 pubmed
    ..In conclusion, our results demonstrate that HIC1 mediates transcriptional repression by both HDAC-independent and HDAC-dependent mechanisms and show that CtBP is a HIC1 corepressor that is recruited via a variant binding site. ..
  34. Norton J, Wang C, Gjidoda A, Henry R, Huang S. The perinucleolar compartment is directly associated with DNA. J Biol Chem. 2009;284:4090-101 pubmed publisher
    ..Together, these studies validate PNC disassembly as a screening marker to identify chemical probes and revealed that the PNC is directly nucleated on a DNA locus, suggesting a potential role for the PNC in gene expression regulation. ..
  35. Lin R, Sternsdorf T, Tini M, Evans R. Transcriptional regulation in acute promyelocytic leukemia. Oncogene. 2001;20:7204-15 pubmed
    ..These studies have been instrumental in our understanding of the process of leukemogenesis in general and have laid the scientific foundation for the novel concept of transcription therapy in the treatment of human cancer. ..
  36. Kashuba E, Mattsson K, Klein G, Szekely L. p14ARF induces the relocation of HDM2 and p53 to extranucleolar sites that are targeted by PML bodies and proteasomes. Mol Cancer. 2003;2:18 pubmed
    ..Accumulation of PML and proteasomes at these sites suggest that the components of the nuclear inclusions are targeted for proteasome-mediated degradation. ..
  37. Marban C, Redel L, Suzanne S, Van Lint C, Lecestre D, Chasserot Golaz S, et al. COUP-TF interacting protein 2 represses the initial phase of HIV-1 gene transcription in human microglial cells. Nucleic Acids Res. 2005;33:2318-31 pubmed
    ..Since our findings demonstrate that CTIP2 interacts with the HIV-1 proximal promoter, it is likely that CTIP2 promotes HIV-1 gene silencing by forcing transcriptionally repressed heterochromatic environment to the viral LTR region. ..
  38. Carmo Fonseca M. How genes find their way inside the cell nucleus. J Cell Biol. 2007;179:1093-4 pubmed
    ..In this issue, for the first time, a gene locus moving toward a subnuclear compartment was tracked. Motion of the locus is actin dependent, raising the question of whether chromatin movements are random or directed. ..
  39. Loiodice I, Alves A, Rabut G, Van Overbeek M, Ellenberg J, Sibarita J, et al. The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis. Mol Biol Cell. 2004;15:3333-44 pubmed
    ..Together, our results indicate that the entire Nup107-160 complex, which comprises nearly one-third of the so-far identified nucleoporins, specifically localizes to kinetochores in mitosis. ..
  40. Bensaid M, Melko M, Bechara E, Davidovic L, Berretta A, Catania M, et al. FRAXE-associated mental retardation protein (FMR2) is an RNA-binding protein with high affinity for G-quartet RNA forming structure. Nucleic Acids Res. 2009;37:1269-79 pubmed publisher
    ..All together, our findings strongly suggest that FMR2 is an RNA-binding protein, which might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure. ..
  41. Batalova F, Parfenov V. Immunomorphological localization of Vasa protein and pre-mRNA splicing factors in Panorpa communis trophocytes and oocytes. Cell Biol Int. 2003;27:795-807 pubmed
    ..Using immunoelectron microscopy, we also show small nuclear RNPs both in trophocyte PBs of the 2nd type and in oocyte PBs. The functional significance of coupling in the same structure of Vasa protein and snRNPs is discussed. ..
  42. Zbroch T, Knapp P, Knapp P. [Implementation of cytology images classification--the Bethesda 2001 System--in a group of screened women from Podlaskie region--effect evaluation]. Ginekol Pol. 2007;78:685-90 pubmed
  43. Matunis M, Zhang X, Ellis N. SUMO: the glue that binds. Dev Cell. 2006;11:596-7 pubmed
  44. Lopez P, Jacob R, Roizman B. Overexpression of promyelocytic leukemia protein precludes the dispersal of ND10 structures and has no effect on accumulation of infectious herpes simplex virus 1 or its proteins. J Virol. 2002;76:9355-67 pubmed
    ..ii) PML does not affect viral replication or the changes in the localization of ICP0 through infection. (iii) Disaggregation of ND10 structures is not an obligatory event essential for viral replication. ..
  45. Evans J, Hearing P. Distinct roles of the Adenovirus E4 ORF3 protein in viral DNA replication and inhibition of genome concatenation. J Virol. 2003;77:5295-304 pubmed
    ..This function is distinct from the role of E4 ORF3 in the regulation of virus genome concatenation via inhibition of cellular double-strand break repair. ..
  46. Herbert A. Proposed Sheffield quantitative criteria in cervical cytology to assist the diagnosis and grading of squamous intraepithelial lesions and dyskaryosis as the Bethesda System and British Society for Clinical Cytology definitions require amendment. Cytopathology. 2005;16:165-6 pubmed
  47. Takahashi A, Higashino F, Aoyagi M, Yoshida K, Itoh M, Kobayashi M, et al. E1AF degradation by a ubiquitin-proteasome pathway. Biochem Biophys Res Commun. 2005;327:575-80 pubmed
    ..These results suggest that E1AF is degraded via the ubiquitin-proteasome pathway, which has some effect on E1AF function. ..
  48. Chen N, Garner A, Chen G, Jing Y, Deng Y, Swanson R, et al. Nanosecond electric pulses penetrate the nucleus and enhance speckle formation. Biochem Biophys Res Commun. 2007;364:220-5 pubmed
    ..The resulting nuclear speckle changes were also cell cycle dependent. These findings suggest that 10ns pulses directly influenced nuclear processes, such as the changes in the nuclear RNA-protein complexes. ..
  49. Berulava T, Ziehe M, Klein Hitpass L, Mladenov E, Thomale J, Ruther U, et al. FTO levels affect RNA modification and the transcriptome. Eur J Hum Genet. 2013;21:317-23 pubmed publisher
    ..We conclude that altered levels of FTO have multiple and diverse consequences on RNA modifications and the transcriptome. ..
  50. Sakashita E, Tatsumi S, Werner D, Endo H, Mayeda A. Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo. Mol Cell Biol. 2004;24:1174-87 pubmed
    ..RNPS1 appears to be a versatile factor that regulates alternative splicing of a variety of pre-mRNAs. ..
  51. Stepanova I, Bogoliubov D. [RNA polymerase II and pre-mRNA splicing factors in diplotene oocyte nuclei of the giant African gastropod Achatina fulica]. Tsitologiia. 2003;45:166-78 pubmed
    ..No snRNPs were revealed in this material. Homology of A. fulica oocyte nuclear structures to Cajal bodies and interchromatin granule clusters is discussed...
  52. Kang H, Kim E, Lee H, Park J, Go Y, Choi C, et al. Inhibition of SUMO-independent PML oligomerization by the human cytomegalovirus IE1 protein. J Gen Virol. 2006;87:2181-90 pubmed
    ..The finding that IE1 is capable of disrupting SUMO-independent PML aggregates suggests that inhibition of PML oligomerization by IE1 may play an important role in inducing PML desumoylation in vivo...
  53. Eils R, Athale C. Computational imaging in cell biology. J Cell Biol. 2003;161:477-81 pubmed
    ..These applications illustrate the potential of computational imaging to enhance our knowledge of the dynamics of cellular structures and processes...
  54. Batalova F, Bogoliubov D, Parfenov V. [Karyosphere and extrachromosomal nuclear bodies in oocytes of the scorpionfly, Panorpa communis]. Tsitologiia. 2005;47:847-59 pubmed
    ..In inactivated oocyte nuclei, CBs serve presumably as storage compartments for some inactive components essential for gene expression...
  55. Dernburg A, Misteli T. Nuclear architecture--an island no more. Dev Cell. 2007;12:329-34 pubmed
    ..Emerging from this conference was a holistic view in which diverse chemical and physical signals link the nuclear and cytoplasmic compartments of cells...
  56. Bhattacharyya S, Keirsey J, Russell B, Kavecansky J, Lillard Wetherell K, Tahmaseb K, et al. Telomerase-associated protein 1, HSP90, and topoisomerase IIalpha associate directly with the BLM helicase in immortalized cells using ALT and modulate its helicase activity using telomeric DNA substrates. J Biol Chem. 2009;284:14966-77 pubmed publisher
    ..Initial studies suggest that knockdown of BLM in ALT cells reduces average telomere length but does not do so in cells using telomerase...
  57. Straub T, Neumann M, Prestel M, Kremmer E, Kaether C, Haass C, et al. Stable chromosomal association of MSL2 defines a dosage-compensated nuclear compartment. Chromosoma. 2005;114:352-64 pubmed
    ..Our findings have profound implications for the mechanism underlying dosage compensation and furthermore provide a new, conceptual reference of stability in an otherwise highly dynamic nuclear environment...
  58. Kavanagh S, Schulz T, Davey P, Claudianos C, Russell C, Rathjen P. A family of RS domain proteins with novel subcellular localization and trafficking. Nucleic Acids Res. 2005;33:1309-22 pubmed
    ..Integration of Psc1 into cytospeckles was dependent on the RRM. Cytospeckles were dynamic within the cytoplasm and appeared to traffic into the nucleus. These observations suggest a novel role in RNA metabolism for ARRS proteins...
  59. Noll L, Peterson F, Hayes P, Volkman B, Sander T. Heterodimer formation of the myeloid zinc finger 1 SCAN domain and association with promyelocytic leukemia nuclear bodies. Leuk Res. 2008;32:1582-92 pubmed publisher
    ..Altogether, these data suggest that MZF1 is recruited to PML-NBs and that the SCAN domain may play an integral role in regulating the localization of heterodimeric protein complexes to these intranuclear structures...
  60. Alliegro M, Alliegro M. Localization of rRNA transcribed spacer domains in the nucleolinus and maternal procentrosomes of surf clam (Spisula) oocytes. RNA Biol. 2013;10:391-6 pubmed publisher
  61. Morello L, Hesling C, Coltri P, Castilho B, Rimokh R, Zanchin N. The NIP7 protein is required for accurate pre-rRNA processing in human cells. Nucleic Acids Res. 2011;39:648-65 pubmed publisher
    ..Downregulation of NIP7 affects cell proliferation, consistently with an important role for NIP7 in rRNA biosynthesis in human cells...
  62. Tang Q, Li L, Ishov A, Revol V, Epstein A, Maul G. Determination of minimum herpes simplex virus type 1 components necessary to localize transcriptionally active DNA to ND10. J Virol. 2003;77:5821-8 pubmed
    ..Such a complex might be more likely immobilized at the outside of ND10 by the PML-interacting Daxx than at other nuclear sites...
  63. Washiya K, Sato T, Miura T, Tone K, Kojima K, Watanabe J, et al. Cytologic difference between benignity and malignancy in suspicious cases employing urine cytodiagnosis using a liquid-based method. Anal Quant Cytol Histol. 2011;33:169-74 pubmed
    ..To follow cases with atypical cells or suspicious cases on first examination by liquid-based cytology (LBC), comparing cases that became negative and those confirmed to be positive (urothelial carcinoma) with regard to the cell morphology...
  64. Medina F, Cerdido A, de Carcer G. The functional organization of the nucleolus in proliferating plant cells. Eur J Histochem. 2000;44:117-31 pubmed
  65. Willadsen K, Mohamad N, Boden M. NSort/DB: an intranuclear compartment protein database. Genomics Proteomics Bioinformatics. 2012;10:226-9 pubmed publisher
    ..nsort.org/db/. Availability of this data set will enable systematic analyses of the protein complements of nuclear compartments, improving our understanding of the diverse functional repertoire of these structures...
  66. Sytnikova Y, Kubarenko A, Sch fer A, Weber A, Niehrs C. Gadd45a is an RNA binding protein and is localized in nuclear speckles. PLoS ONE. 2011;6:e14500 pubmed publisher
    ..The results implicate RNA in Gadd45a function and suggest that Gadd45a is associated with a ribonucleoprotein particle...
  67. Scadden D. A NEAT way of regulating nuclear export of mRNAs. Mol Cell. 2009;35:395-6 pubmed publisher
    ..In this issue of Molecular Cell, Chen and Carmichael (2009) demonstrate that the noncoding RNA NEAT1 regulates gene expression by restricting nuclear export...
  68. Harata M, Kitayama K, Oma Y. [Nuclear structure: its molecular basis and dynamics]. Tanpakushitsu Kakusan Koso. 2006;51:591-9 pubmed
  69. Fontenele Neto J, Massarelli E, Gurgel Garrido P, Beaudet A, Ferro E. Comparative fine structural distribution of endopeptidase 24.15 (EC3.4.24.15) and 24.16 (EC3.4.24.16) in rat brain. J Comp Neurol. 2001;438:399-410 pubmed
    ..Taken together, the present results suggest that EP24.15 could play a major role in the hydrolysis of intranuclear substrates, whereas EP24.16 would be predominantly involved in the processing and inactivation of signaling peptides...
  70. Nagamine T, Kawasaki Y, Iizuka T, Matsumoto S. Focal distribution of baculovirus IE1 triggered by its binding to the hr DNA elements. J Virol. 2005;79:39-46 pubmed
    ..The observation of BmNPV IE1 foci in non-BmNPV-susceptible cells suggests that no species-specific factors are required for hr-dependent IE1 focus formation...
  71. Fukuyo Y, Mogi K, Tsunematsu Y, Nakajima T. E2FBP1/hDril1 modulates cell growth through downregulation of promyelocytic leukemia bodies. Cell Death Differ. 2004;11:747-59 pubmed
    ..Thus, the function of E2FBP1/hDril1 is required for maintenance of survival potential of the cells. Our data suggest a novel mechanism to govern cellular integrity through the modulation of nuclear depots...
  72. Sciurano R, Rahn M, Rey Valzacchi G, Solari A. The asynaptic chromatin in spermatocytes of translocation carriers contains the histone variant gamma-H2AX and associates with the XY body. Hum Reprod. 2007;22:142-50 pubmed
    ..Because in many of these carriers spermatogenesis is deeply disturbed at the spermatocyte level, the association of autosomal chromatin with the XY body may impair the spermatocyte life...
  73. Manfiolli A, Maragno A, Baqui M, Yokoo S, Teixeira F, Oliveira E, et al. FBXO25-associated nuclear domains: a novel subnuclear structure. Mol Biol Cell. 2008;19:1848-61 pubmed publisher
  74. Wong J, Farlie P, Holbert S, Lockhart P, Thomas P. Polyalanine expansion mutations in the X-linked hypopituitarism gene SOX3 result in aggresome formation and impaired transactivation. Front Biosci. 2007;12:2085-95 pubmed
    ..These data suggest that deregulation of SOX3 target genes and inappropriate canonical Wnt signaling in central nervous system (CNS) progenitors may also contribute to dysfunction of the hypothalamic-pituitary axis in XH patients...
  75. Valgardsdottir R, Chiodi I, Giordano M, Rossi A, Bazzini S, Ghigna C, et al. Transcription of Satellite III non-coding RNAs is a general stress response in human cells. Nucleic Acids Res. 2008;36:423-34 pubmed
    ..This is the first example of a non-coding RNA whose transcription is controlled by different transcription factors under different growth conditions...
  76. Friedman J, Chang B, Kannabiran C, Chakarova C, Singh H, Jalali S, et al. Premature truncation of a novel protein, RD3, exhibiting subnuclear localization is associated with retinal degeneration. Am J Hum Genet. 2006;79:1059-70 pubmed
    ..We suggest that the retinopathy-associated RD3 protein is part of subnuclear protein complexes involved in diverse processes, such as transcription and splicing...
  77. Wu Y, Kawate H, Ohnaka K, Nawata H, Takayanagi R. Nuclear compartmentalization of N-CoR and its interactions with steroid receptors. Mol Cell Biol. 2006;26:6633-55 pubmed
    ..The focus formation may reflect the accumulation of SHR/coactivator complexes released from the transcriptionally active sites and thus be a mirror of transcriptionally active complex formation...