organelles

Summary

Summary: Specific particles of membrane-bound organized living substances present in eukaryotic cells, such as the MITOCHONDRIA; the GOLGI APPARATUS; ENDOPLASMIC RETICULUM; LYSOSOMES; PLASTIDS; and VACUOLES.

Top Publications

  1. Shim S, Xia C, Zhong G, Babcock H, Vaughan J, Huang B, et al. Super-resolution fluorescence imaging of organelles in live cells with photoswitchable membrane probes. Proc Natl Acad Sci U S A. 2012;109:13978-83 pubmed publisher
    Imaging membranes in live cells with nanometer-scale resolution promises to reveal ultrastructural dynamics of organelles that are essential for cellular functions...
  2. Borkowski A, Park K, Uchida Y, Gallo R. Activation of TLR3 in keratinocytes increases expression of genes involved in formation of the epidermis, lipid accumulation, and epidermal organelles. J Invest Dermatol. 2013;133:2031-40 pubmed publisher
    ..These observations show that dsRNA can stimulate some events in keratinocytes that are important for skin barrier repair and maintenance. ..
  3. Weis B, Schleiff E, Zerges W. Protein targeting to subcellular organelles via MRNA localization. Biochim Biophys Acta. 2013;1833:260-73 pubmed
    Cells have complex membranous organelles for the compartmentalization and the regulation of most intracellular processes...
  4. Vineetha V, Prathapan A, Soumya R, Raghu K. Arsenic trioxide toxicity in H9c2 myoblasts--damage to cell organelles and possible amelioration with Boerhavia diffusa. Cardiovasc Toxicol. 2013;13:123-37 pubmed publisher
    ..protective property of ethanolic extract of Boerhavia diffusa (BDE) against ATO-induced toxicity on various cell organelles in H9c2 cardiomyocytes. The effects of different concentrations of ATO (5, 7...
  5. Moromizato S, Hisamatsu Y, Suzuki T, Matsuo Y, Abe R, Aoki S. Design and synthesis of a luminescent cyclometalated iridium(III) complex having N,N-diethylamino group that stains acidic intracellular organelles and induces cell death by photoirradiation. Inorg Chem. 2012;51:12697-706 pubmed publisher
    ..Moreover, complex 5 is capable of generating singlet oxygen in a pH-dependent manner and inducing the death of HeLa-S3 cells upon photoirradiation at 377 or 470 nm...
  6. English A, Voeltz G. Endoplasmic reticulum structure and interconnections with other organelles. Cold Spring Harb Perspect Biol. 2013;5:a013227 pubmed publisher
    ..synthesis of proteins and lipids, calcium level regulation, and exchange of macromolecules with various organelles at ER-membrane contact sites...
  7. Gubbels M, Duraisingh M. Evolution of apicomplexan secretory organelles. Int J Parasitol. 2012;42:1071-81 pubmed publisher
    ..Here the evolution of apicomplexan secretory organelles that are involved in the critical process of egress from one cell and invasion of another is explored...
  8. Klinger C, Nisbet R, Ouologuem D, Roos D, Dacks J. Cryptic organelle homology in apicomplexan parasites: insights from evolutionary cell biology. Curr Opin Microbiol. 2013;16:424-31 pubmed publisher
    ..Distinctive intracellular organelles play key roles in parasite motility, invasion, metabolism, and replication, and understanding their relationship ..
  9. Brangwynne C. Phase transitions and size scaling of membrane-less organelles. J Cell Biol. 2013;203:875-81 pubmed publisher
    The coordinated growth of cells and their organelles is a fundamental and poorly understood problem, with implications for processes ranging from embryonic development to oncogenesis...

More Information

Publications62

  1. Belov G, van Kuppeveld F. (+)RNA viruses rewire cellular pathways to build replication organelles. Curr Opin Virol. 2012;2:740-7 pubmed publisher
    ..of (+)RNA viruses for cellular membranes for genome replication, and the formation of membranous replication organelles with similar architecture, suggest that they target essential control mechanisms of membrane metabolism ..
  2. Spokoini R, Moldavski O, Nahmias Y, England J, Schuldiner M, Kaganovich D. Confinement to organelle-associated inclusion structures mediates asymmetric inheritance of aggregated protein in budding yeast. Cell Rep. 2012;2:738-47 pubmed publisher
    ..quality control compartment (JUNQ) and insoluble protein deposit (IPOD) inclusions, which are attached to organelles. Upon exposure to stress, misfolded proteins accumulate in stress foci that must be disaggregated by Hsp104 in ..
  3. Chan Y, Marshall W. How cells know the size of their organelles. Science. 2012;337:1186-9 pubmed publisher
    Cells have developed ways to sense and control the size of their organelles. Size-sensing mechanisms range from direct measurements provided by dedicated reporters to indirect functional readouts, and they are used to modify organelle ..
  4. Kagan J. Signaling organelles of the innate immune system. Cell. 2012;151:1168-78 pubmed publisher
    ..innate immune signal transduction and then offer a model whereby structurally distinct proteins can be grouped functionally through their ability to assemble platforms of regulators on the signaling organelles of the innate immune system.
  5. Ding Y, Zhang S, Yang L, Na H, Zhang P, Zhang H, et al. Isolating lipid droplets from multiple species. Nat Protoc. 2013;8:43-51 pubmed publisher
    ..On the basis of previous studies, this 7-h protocol can yield 15-100 ?g of protein-equivalent high-quality LDs that satisfy the requirements for current LD research in most organisms...
  6. Polishchuk R, Polishchuk E, Luini A. Visualizing live dynamics and ultrastructure of intracellular organelles with preembedding correlative light-electron microscopy. Methods Cell Biol. 2012;111:21-35 pubmed publisher
    ..This technique can thus provide detailed, high-resolution characterization of dynamic intracellular organelles. The use of green fluorescent protein (GFP)-tagged chimeras allows the movements and/or behavior of ..
  7. Heald R, COHEN FIX O. Morphology and function of membrane-bound organelles. Curr Opin Cell Biol. 2014;26:79-86 pubmed publisher
    The cell interior is a busy and crowded place. A large fraction of the cell volume is taken up by organelles that come in a variety of shapes and sizes...
  8. Gheiratmand L, Brasseur A, Zhou Q, He C. Biochemical characterization of the bi-lobe reveals a continuous structural network linking the bi-lobe to other single-copied organelles in Trypanosoma brucei. J Biol Chem. 2013;288:3489-99 pubmed publisher
    Trypanosoma brucei, a unicellular parasite, contains several single-copied organelles that duplicate and segregate in a highly coordinated fashion during the cell cycle...
  9. Mueller C, Klages N, Jacot D, Santos J, Cabrera A, Gilberger T, et al. The Toxoplasma protein ARO mediates the apical positioning of rhoptry organelles, a prerequisite for host cell invasion. Cell Host Microbe. 2013;13:289-301 pubmed publisher
    ..actively enter host cells by a process involving the discharge of the apically localized microneme and rhoptry organelles. To unravel the processes involved in rhoptry organelle biogenesis, we focused on the Toxoplasma gondii ..
  10. Delling M, DeCaen P, Doerner J, Febvay S, Clapham D. Primary cilia are specialized calcium signalling organelles. Nature. 2013;504:311-4 pubmed publisher
    ..PKD1L1-PKD2L1 acts as a ciliary calcium channel controlling ciliary calcium concentration and thereby modifying SMO-activated GLI2 translocation and GLI1 expression. ..
  11. Kremer K, Kamin D, Rittweger E, Wilkes J, Flammer H, Mahler S, et al. An overexpression screen of Toxoplasma gondii Rab-GTPases reveals distinct transport routes to the micronemes. PLoS Pathog. 2013;9:e1003213 pubmed publisher
    ..appear to have only a basic set of trafficking factors such as Rab-GTPases, they evolved unique secretory organelles (micronemes, rhoptries and dense granules) that are sequentially secreted during invasion of the host cell...
  12. Yeates T, Jorda J, Bobik T. The shells of BMC-type microcompartment organelles in bacteria. J Mol Microbiol Biotechnol. 2013;23:290-9 pubmed publisher
    Bacterial microcompartments are large proteinaceous structures that act as metabolic organelles in many bacterial cells...
  13. Lim Y, Tang B. Intercellular organelle trafficking by membranous nanotube connections: a possible new role in cellular rejuvenation?. Cell Commun Adhes. 2012;19:39-44 pubmed publisher
    ..hand, tunneling nanotubes (TNTs) form conduits with open ends that allow transfer of cytoplasmic materials and organelles between cells...
  14. Rubio N, Coupienne I, Di Valentin E, Heirman I, Grooten J, Piette J, et al. Spatiotemporal autophagic degradation of oxidatively damaged organelles after photodynamic stress is amplified by mitochondrial reactive oxygen species. Autophagy. 2012;8:1312-24 pubmed publisher
    ..autophagic pathways, how ROS or their secondary products modulate the selective clearance of oxidatively damaged organelles is less explored...
  15. Rodríguez García A, Rojo Ruiz J, Navas Navarro P, Aulestia F, Gallego Sandín S, Garcia Sancho J, et al. GAP, an aequorin-based fluorescent indicator for imaging Ca2+ in organelles. Proc Natl Acad Sci U S A. 2014;111:2584-9 pubmed publisher
    Genetically encoded calcium indicators allow monitoring subcellular Ca(2+) signals inside organelles. Most genetically encoded calcium indicators are fusions of endogenous calcium-binding proteins whose functionality in vivo may be ..
  16. Nicolson G, Ash M. Lipid Replacement Therapy: a natural medicine approach to replacing damaged lipids in cellular membranes and organelles and restoring function. Biochim Biophys Acta. 2014;1838:1657-79 pubmed publisher
    ..This Article is Part of a Special Issue Entitled: Membrane Structure and Function: Relevance in the Cell's Physiology, Pathology and Therapy. ..
  17. Bigay J, Antonny B. Curvature, lipid packing, and electrostatics of membrane organelles: defining cellular territories in determining specificity. Dev Cell. 2012;23:886-95 pubmed publisher
    Whereas some rare lipids contribute to the identity of cell organelles, we focus on the abundant lipids that form the matrix of organelle membranes...
  18. de Mattos K, Sarno E, Pessolani M, Bozza P. Deciphering the contribution of lipid droplets in leprosy: multifunctional organelles with roles in Mycobacterium leprae pathogenesis. Mem Inst Oswaldo Cruz. 2012;107 Suppl 1:156-66 pubmed
    ..Here, we discuss the contemporary view of LD as highly regulated organelles with key functions in M. leprae persistence in the LL end of the spectrum...
  19. Orlicky D, Monks J, Stefanski A, McManaman J. Dynamics and molecular determinants of cytoplasmic lipid droplet clustering and dispersion. PLoS ONE. 2013;8:e66837 pubmed publisher
    ..Together these data suggest that the clustering and dispersion processes involve a complex orchestration of phosphorylation-dependent, microtubule-dependent and independent, and microfilament dependent steps. ..
  20. Pohlschroder M, Ghosh A, Tripepi M, Albers S. Archaeal type IV pilus-like structures--evolutionarily conserved prokaryotic surface organelles. Curr Opin Microbiol. 2011;14:357-63 pubmed publisher
    ..The insights gleaned from these studies may also elucidate the roles played by these types of structures in adapting to specific environments...
  21. Castandet B, Araya A. RNA editing in plant organelles. Why make it easy?. Biochemistry (Mosc). 2011;76:924-31 pubmed publisher
    Gene expression in plant organelles involves a number of distinct co- or posttranscriptional nucleic acid modifications: 5' and 3' RNA processing, cis- and trans-splicing, RNA stability, and RNA editing...
  22. Wang C, Lee S. The ubiquitin-like (UBX)-domain-containing protein Ubx2/Ubxd8 regulates lipid droplet homeostasis. J Cell Sci. 2012;125:2930-9 pubmed publisher
    Lipid droplets (LDs) are central organelles for maintaining lipid homeostasis. However, how cells control the size and number of LDs remains largely unknown...
  23. Baudisch B, Klösgen R. Dual targeting of a processing peptidase into both endosymbiotic organelles mediated by a transport signal of unusual architecture. Mol Plant. 2012;5:494-503 pubmed publisher
    ..have dual targeting properties, that is, they are recognized both by mitochondria and by chloroplasts as target organelles. We have identified alpha-MPP2, one of the two isoforms of the substrate binding subunit of mitochondrial ..
  24. Hawes C, Osterrieder A, Sparkes I, Ketelaar T. Optical tweezers for the micromanipulation of plant cytoplasm and organelles. Curr Opin Plant Biol. 2010;13:731-5 pubmed publisher
    ..Thus, it is theoretically possible to trap and manipulate organelles within the cytoplasm and remodel the architecture of the cytoplasm and membrane systems...
  25. Caballero M, Pedroni M, Palmer G, Suarez C, Davitt C, Lau A. Characterization of acyl carrier protein and LytB in Babesia bovis apicoplast. Mol Biochem Parasitol. 2012;181:125-33 pubmed publisher
    ..The results indicate specialized molding of apicoplast biosynthetic pathways to meet the requirements of individual apicomplexan parasites and their unique intracellular niches...
  26. Mak H. Lipid droplets as fat storage organelles in Caenorhabditis elegans: Thematic Review Series: Lipid Droplet Synthesis and Metabolism: from Yeast to Man. J Lipid Res. 2012;53:28-33 pubmed publisher
    Lipid droplets are evolutionarily conserved organelles where cellular fat storage and mobilization are exquisitely regulated. Recent studies have defined lipid droplets in C...
  27. Gao Y, Cao X, Kang F, Cheng Z. PAHs pass through the cell wall and partition into organelles of arbuscular mycorrhizal roots of ryegrass. J Environ Qual. 2011;40:653-6 pubmed
    ..as a representative PAH passed through the cell-wall boundary, dissolved in the cell solution, and partition organelles in arbuscular mycorrhizal roots of ryegrass (Lolium multiflorum Lam.)...
  28. Rada P, Dolezal P, Jedelský P, Bursac D, Perry A, Sedinová M, et al. The core components of organelle biogenesis and membrane transport in the hydrogenosomes of Trichomonas vaginalis. PLoS ONE. 2011;6:e24428 pubmed publisher
    ..Consequently, all hydrogenosomal proteins are encoded in the nucleus and imported into the organelles. However, little is known about the membrane machineries required for biogenesis of the organelle and metabolite ..
  29. Walther T, Farese R. Lipid droplets and cellular lipid metabolism. Annu Rev Biochem. 2012;81:687-714 pubmed publisher
    Among organelles, lipid droplets (LDs) uniquely constitute a hydrophobic phase in the aqueous environment of the cytosol...
  30. Ito D, Han E, Takeo S, Thongkukiatkul A, Otsuki H, Torii M, et al. Plasmodial ortholog of Toxoplasma gondii rhoptry neck protein 3 is localized to the rhoptry body. Parasitol Int. 2011;60:132-8 pubmed publisher
    The proteins in apical organelles of Plasmodium falciparum merozoite play an important role in invasion into erythrocytes...
  31. Lu F, Xu W, Tian C, Wang G, Niu J, Pan G, et al. The Bryopsis hypnoides plastid genome: multimeric forms and complete nucleotide sequence. PLoS ONE. 2011;6:e14663 pubmed publisher
    ..The chloroplast of B. hypnoides is the biggest organelle in the cell and shows strong autonomy. To better understand this organelle, we sequenced and analyzed the chloroplast genome of this green alga...
  32. Melo R, D Avila H, Wan H, Bozza P, Dvorak A, Weller P. Lipid bodies in inflammatory cells: structure, function, and current imaging techniques. J Histochem Cytochem. 2011;59:540-56 pubmed publisher
    Lipid bodies (LBs), also known as lipid droplets, have increasingly been recognized as functionally active organelles linked to diverse biological functions and human diseases...
  33. Kinney J, Axen S, Kerfeld C. Comparative analysis of carboxysome shell proteins. Photosynth Res. 2011;109:21-32 pubmed publisher
    ..In the future, further understanding of these molecular building blocks may provide the basis for enhancing CO(2) fixation in other organisms or creating novel biological nanostructures...
  34. Ariotti N, Murphy S, Hamilton N, Wu L, Green K, Schieber N, et al. Postlipolytic insulin-dependent remodeling of micro lipid droplets in adipocytes. Mol Biol Cell. 2012;23:1826-37 pubmed publisher
    ..We identify a physiologically important role for LD fusion that is involved in a reversible lipolytic cycle in adipocytes...
  35. Rangel R, Guzman Rojas L, Le Roux L, Staquicini F, Hosoya H, Barbu E, et al. Combinatorial targeting and discovery of ligand-receptors in organelles of mammalian cells. Nat Commun. 2012;3:788 pubmed publisher
    ..allows the study of functional protein-protein interactions at the cell surface, but investigating intracellular organelles remains a challenge...
  36. D Avila H, Toledo D, Melo R. Lipid bodies: inflammatory organelles implicated in host-Trypanosoma cruzi interplay during innate immune responses. Mediators Inflamm. 2012;2012:478601 pubmed publisher
    ..feature of Chagas' disease-triggered macrophages is the presence of increased numbers of distinct cytoplasmic organelles termed lipid bodies or lipid droplets...
  37. Kimura K, Kimura A. Intracellular organelles mediate cytoplasmic pulling force for centrosome centration in the Caenorhabditis elegans early embryo. Proc Natl Acad Sci U S A. 2011;108:137-42 pubmed publisher
    ..Here, we provide evidence that a population of dynein, which is located on intracellular organelles and is responsible for organelle transport toward the centrosome, generates the force required for centrosome ..
  38. Pandey J, Smith D. A Cdk5-dependent switch regulates Lis1/Ndel1/dynein-driven organelle transport in adult axons. J Neurosci. 2011;31:17207-19 pubmed publisher
    ..Here, we monitored acidic organelles moving in axons of adult rat sensory neurons to determine whether Lis1 and Ndel1 contribute to axonal transport...
  39. Figueira T, Melo D, Vercesi A, Castilho R. Safranine as a fluorescent probe for the evaluation of mitochondrial membrane potential in isolated organelles and permeabilized cells. Methods Mol Biol. 2012;810:103-17 pubmed publisher
    ..Here, we describe the use of safranine as a fluorescent indicator of ?? in isolated mitochondria and digitonin-permeabilized cells. We present suitable conditions to employ safranine as a ?? indicator...
  40. Chapman K, Dyer J, Mullen R. Biogenesis and functions of lipid droplets in plants: Thematic Review Series: Lipid Droplet Synthesis and Metabolism: from Yeast to Man. J Lipid Res. 2012;53:215-26 pubmed publisher
    ..In addition, several other proteins known to be important in LD biogenesis in yeasts and mammals are conserved in plants, suggesting that at least some aspects of LD biogenesis and/or function are evolutionarily conserved...
  41. Harris D, Kim K, Nakahara K, Vásquez Doorman C, Carthew R. Cargo sorting to lysosome-related organelles regulates siRNA-mediated gene silencing. J Cell Biol. 2011;194:77-87 pubmed publisher
    ..Negative regulation is also not linked to sorting into all LROs but only a specific class of pigment LRO. Thus, regulation of siRNA activity is tied to sorting of specific types of cargo to particular LROs...
  42. Kitamura N, Nakamura Y, Miyamoto Y, Miyamoto T, Kabu K, Yoshida M, et al. Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria. PLoS ONE. 2011;6:e16060 pubmed publisher
    ..elimination of oxidized mitochondrial proteins (designated MALM for Mieap-induced accumulation of lysosome-like organelles within mitochondria). However, a large part of the mechanisms for MQC remains unknown...
  43. Lee S, Sato Y, Nixon R. Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy. J Neurosci. 2011;31:7817-30 pubmed publisher
    ..Mitochondria and other organelles lacking cathepsins moved normally under these conditions, indicating that the general functioning of the axonal ..
  44. Tanner P, Egli S, Balasubramanian V, Onaca O, Palivan C, Meier W. Can polymeric vesicles that confine enzymatic reactions act as simplified organelles?. FEBS Lett. 2011;585:1699-706 pubmed publisher
    ..be achieved, for example, by enzyme replacement therapy, which can amplify specific, intrinsic activities of the organelles. In this respect, polymeric nanoreactors composed of vesicles that encapsulate an enzyme or a combination of ..
  45. Mano S, Miwa T, Nishikawa S, Mimura T, Nishimura M. The Plant Organelles Database 2 (PODB2): an updated resource containing movie data of plant organelle dynamics. Plant Cell Physiol. 2011;52:244-53 pubmed publisher
    The Plant Organelles Database (PODB) was launched in 2006 and provides imaging data of plant organelles, protocols for plant organelle research and external links to relevant websites...
  46. Ridsdale R, Na C, Xu Y, Greis K, Weaver T. Comparative proteomic analysis of lung lamellar bodies and lysosome-related organelles. PLoS ONE. 2011;6:e16482 pubmed publisher
    ..The lung LB proteome will facilitate identification of molecular pathways involved in LB biogenesis, surfactant homeostasis and disease pathogenesis...
  47. Tawk L, Dubremetz J, Montcourrier P, Chicanne G, Merezegue F, Richard V, et al. Phosphatidylinositol 3-monophosphate is involved in toxoplasma apicoplast biogenesis. PLoS Pathog. 2011;7:e1001286 pubmed publisher
    ..This study also highlights the possibility of developing specific pharmacological inhibitors of the parasite PI3-kinase as novel anti-apicomplexan drugs. ..
  48. Fei W, Du X, Yang H. Seipin, adipogenesis and lipid droplets. Trends Endocrinol Metab. 2011;22:204-10 pubmed publisher
    ..These changes could lead to tissue-specific abnormalities upon seipin dysfunction, such as defective adipocyte development and clustered LDs in fibroblasts...
  49. Long B, Rae B, Badger M, Price G. Over-expression of the ?-carboxysomal CcmM protein in Synechococcus PCC7942 reveals a tight co-regulation of carboxysomal carbonic anhydrase (CcaA) and M58 content. Photosynth Res. 2011;109:33-45 pubmed publisher
    ..Determination of absolute protein quantities supports the hypothesis that M35 is distributed throughout the ?-carboxysome. A modified ?-carboxysome packing model is presented...
  50. Nair S, Brooks C, Goodman C, Sturm A, Strurm A, McFadden G, et al. Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii. J Exp Med. 2011;208:1547-59 pubmed publisher
    ..We propose that the varied extent of metabolite exchange between host and parasite is a crucial determinator of drug susceptibility and a predictor of future resistance...
  51. Murphy D. The dynamic roles of intracellular lipid droplets: from archaea to mammals. Protoplasma. 2012;249:541-85 pubmed publisher
    ..technologies have underpinned these advances, which are revealing much new information about these dynamic organelles. This review takes a comparative approach by examining recent work on LDs across the whole range of biological ..
  52. Gong J, Sun Z, Wu L, Xu W, Schieber N, Xu D, et al. Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites. J Cell Biol. 2011;195:953-63 pubmed publisher
    Lipid droplets (LDs) are dynamic cellular organelles that control many biological processes. However, molecular components determining LD growth are poorly understood...
  53. Mokarizadeh A, Delirezh N, Morshedi A, Mosayebi G, Farshid A, Mardani K. Microvesicles derived from mesenchymal stem cells: potent organelles for induction of tolerogenic signaling. Immunol Lett. 2012;147:47-54 pubmed publisher
    ..Recent study suggests MSC-derived MVs as potent organelles for induction of peripheral tolerance and modulation of immune responses.