spindle pole bodies


Summary: Microtubule organizing centers of FUNGI and DIATOMS. They are embedded in the NUCLEAR ENVELOPE and evolve into the spindle apparatus during CELL DIVISION.

Top Publications

  1. Botchkarev V, Garabedian M, Lemos B, Paulissen E, Haber J. The budding yeast Polo-like kinase localizes to distinct populations at centrosomes during mitosis. Mol Biol Cell. 2017;28:1011-1020 pubmed publisher
    ..Cdc5 also localizes to the spindle pole bodies (SPBs) from S phase until the end of mitosis...
  2. Bestul A, Yu Z, Unruh J, Jaspersen S. Molecular model of fission yeast centrosome assembly determined by superresolution imaging. J Cell Biol. 2017;216:2409-2424 pubmed publisher
    Microtubule-organizing centers (MTOCs), known as centrosomes in animals and spindle pole bodies (SPBs) in fungi, are important for the faithful distribution of chromosomes between daughter cells during mitosis as well as for other ..
  3. Arquint C, Gabryjonczyk A, Nigg E. Centrosomes as signalling centres. Philos Trans R Soc Lond B Biol Sci. 2014;369: pubmed publisher
    Centrosomes-as well as the related spindle pole bodies (SPBs) of yeast-have been extensively studied from the perspective of their microtubule-organizing roles...
  4. Renicke C, Allmann A, Lutz A, Heimerl T, Taxis C. The Mitotic Exit Network Regulates Spindle Pole Body Selection During Sporulation of Saccharomyces cerevisiae. Genetics. 2017;206:919-937 pubmed publisher
    ..ascospore formation, such an inheritance mechanism targets the yeast centrosome equivalents, the spindle pole bodies (SPBs) at meiosis II onset...
  5. Rüthnick D, Neuner A, Dietrich F, Kirrmaier D, Engel U, Knop M, et al. Characterization of spindle pole body duplication reveals a regulatory role for nuclear pore complexes. J Cell Biol. 2017;216:2425-2442 pubmed publisher
    ..After SPB insertion, membrane-associated proteins including the conserved Ndc1 encircle the SPB and retain it within the NE. Thus, uncoupling SPB growth from NE insertion unmasks functions of the duplication machinery. ..
  6. Chan K, Alonso Nuñez M, Grallert A, Tanaka K, Connolly Y, Smith D, et al. Dialogue between centrosomal entrance and exit scaffold pathways regulates mitotic commitment. J Cell Biol. 2017;216:2795-2812 pubmed publisher
    ..Such integration of signals emanating from neighboring scaffolds shows how centrosomes/SPBs can integrate inputs from multiple pathways to control cell fate. ..